University of Medicine and Pharmacy „Iuliu Haţieganu” Cluj-Napoca Faculty of PharmacySTUDY GUIDE 1 A. B. C. D. E. - F. - - The mission assumed by the Faculty of Pharmacy in Cluj-Napoca is to provide education services for students enrolled in all study programs in pharmaceutical field, according to the European legislation for the recognition of professional qualifications and to the principles of the European Higher Education Area, and also to conduct scientifical research activity, in agreement with the principles of the European Research.Area. The aim of the study program for the licence in pharmacy with 5 year duration is to form pharmacists as specialists in the field of drugs, with quality university education, whose competence and performances can be recognised at national and European level. The general objectives of the study program for the licence in pharmacy are: to ensure the educational frame that allows the student to attain the legal standard of professional knowledge; to ensure the educational frame that allows the student to acquire the professional intellectual discipline; to ensure the educational frame for the ethical formation of the student regarding life and professional issues; The specific objectives of the study program for the licence in pharmacy are: the adequate knowledge of pharmaceutical and auxiliary substances used for the preparation of medicines; the adequate knowledge of pharmaceutical technology and of physical, chemical, biological and microbiological drug control; the adequate knowledge of metabolism and effects of drugs and toxic substances, as well as the of the use of drugs; the adequate knowledge allowing the evaluation of scientifical data regarding drugs, in order to provide correct informations to patients and collaborators; the adequate knowledge of the legal conditions, as well as of other conditions regarding practicing pharmaceutical activities. The general competences of the graduate of study program for the licence in pharmacy: gathering, analysis and qualitative and quantitative interpretation of data and informations from different alternative sources, from different professional contexts, or from the literature, respectively in order to formulate arguments or to take correct decisions; use of different communication abilities, in writing, orally or even in a foreign language; use of information technologies; assuming responsibilities in elaborating a personal continuing education program; elaboration and performing specific processes in the field of pharmacy. The specific competences of the graduate of study program for the licence in pharmacy: elaboration of pharmaceutical formulations; drugs fabrication and control; drug control in a drug control laboratory; storage, conservation and distribution of drugs; preparation, control, storage and delivery of drugs in community pharmacies; preparation, control, storage and delivery of drugs in hospital pharmacies; delivery of information and consultancy regarding drugs; collaboration with the physician in establishing and monitoring drug treatment; performing pharmacovigilance activities fabrication, control, storage, conservation and distribution of plant products, food supplements, hygiene-cosmetic products, medical devices, veterinary drugs, pharmaceutical and auxiliary substances; performing analysis in biochemistry, toxicology, food and environment hygiene laboratories; performing pharmaceutical marketing and management activities; performing teaching and administration activities. 2 CHAIR OF GENERAL AND INORGANIC CHEMISTRY COURSE TITLE – General and inorganic chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES To provide to first year students in Faculty of Pharmacy a basic culture in chemistry and the knowledge needed for following other speciality courses in pharmacy curriculum. To provide, during practical lessons, the basic knowledge in experimental chemistry and in laboratory practice. PREREQUISITE – Elementary knowledge of general chemistry and inorganic chemistry from high school TEACHING METHODS Lectures using Power Point presentations; Applied exercises, computer simulations; Laboratory practice, experimental proceedings and methods, results evaluation and interpretation. EVALUATION METHODS Tests and oral presentations during the semesters. For the presentations, students are allowed to choose from a list of topics suggested by the department. Oral presentations during classes is followed by comments and questions (10% of the final score). The laboratory practice exam consists in several experiments that have to be performed by the student and it is followed by a short interview during which students explain the obtained results. Practical skills and a correct interpretation of the data are evaluated (20% of the final score). Written exam with short answer questions, problems and exercises. The written exam evaluates the correct understanding and interpretations of each topic (70% of the final score). TEACHING LANGUAGE Romanian for Romanian section French for French section English for English section NUMBER OF HOURS Course – 70 hours (28/42) Practical lessons – 84 hours (42/42) GENERAL AND INORGANIC CHEMISTRY COURSE SYLLABUS 1st SEMESTER 1. Elementary Chemistry– A revision 2. Atom structure Modern concepts of the atomic structure. Atomic orbitals (wave function). Atomic models. Electron configuration (principles). Atomic nucleus. 3. Periodic system of the elements Periodicity law. Different forms of the periodic table. Correlation between physical and chemical properties of elements and their electronic configuration and position in the periodic table. 4. Chemical bonds Ionic bond. Covalent bond. Metallic bond. Intermolecular bonding (hydrogen bonding, van der Waals interactions) – classical theories and quantum chemistry. Bond type – structure – compound properties correlations. 3 2h 3h 2h 6h 8. 6. structure. Isomerism. Formation and stability of coordination compounds. Coordination chemistry General principles. Laboratory practice of specific techniques and methods. Oxidation – reduction reactions. Bonding and electronic structure – crystal field and ligand field theories. Properties of crystal structures – isomorphism. General properties of acid and base. physical and chemical properties. 14. complex formation reactions. 12 – groups of periodic table General group characterization Elements and compounds – preparation. Basic separation and purification techniques: selective dissolution. 2. First aid procedures in case of accident 2. Principles of thermodynamics. Catalysis. 10.5. Qualitative and quantitative expressions of solutions’ concentration. Solubility rules. Crystal structure Crystal lattice. Solution’s properties. Gas. equilibrium constant. 3. 7. 7. 9. 17. sublimation. chromatographic techniques 4. distillation. Presentation of laboratory glassware and materials 3. structure. Plasma 6. Purity criteria and evaluation – melting point. Chemical equilibrium characteristics. chemical equivalent. applications in the pharmacy field. centrifugation. Chemistry of the main group elements: 1. importance and biological role 2. molecular weight. 16. physical and chemical properties. States of matter Solid. water molecules in crystallohydrates 5. Diamagnetic. biological role. 2h 2h 2h 2h 1h 1h 4h 2 SEMESTER 1. ionic reactions. Paramagnetic and Ferromagnetic compounds. biological role. 4. 13. 11. Electric and magnetic proprieties of compounds Compounds’ behaviour in an electric or magnetic field. 9. Solutions General aspects. Ionic polarization. hydrolysis. use. polymorphism. Chemical reaction Types of inorganic chemical reactions – influencing factors. 8. Analytical application. Classes of coordinative compounds. uses. 15. Chemistry of the transition metals – 3. filtration. Liquid. Neutralization. Security and personal safety in the chemistry laboratory. 5. 11. extraction. Kinetics – Reaction rates – influencing factors. 4. Types of crystal lattices. kinetics and equilibrium Fundamentals of thermodynamics. 10. Acid and base strength – parameters of evaluation. Equilibrium in homogenous and heterogeneous systems. 18 groups of periodic table General group characterization Elements and compounds – preparation. Acids and basis Acid and base theories. Fire protection. Le Chatelier’s principle. preparation 4 2h 2h 9h st 3h 3h . applications in the pharmacy field. Classification. Solutions – concentration units. Bioinorganic chemistry – fundamental principles nd 9h 18 h 13 h 2h PRACTICAL LESSONS SYLLABUS 1 SEMESTER 1. 2007. A. oxoacids and salts – preparation and 5h properties. acids – HNO2. [Ni(NH3)6]SO4. H3PO4. nickel . M. Chimie anorganică. Zinc. 2000. Goubard.Oprean. potassium. Cluj-Napoca. Bucureşti. Coman. V. Nemetale şi semimetale. Group 15 – Elements and compounds – preparation and properties Nitrogen. reaction rate – influencing factors. barium – oxides. Group 16 – Elements and compounds – preparation and properties Oxygen. cadmium and mercury – oxides. Valentina Uivaroşi – Chimie anorganică. 5. properties 3. hydroxides and salts – preparation and 3h properties 10. Homogeneous and heterogeneous catalysis 7. hydrogen peroxide. 2003. hydroxide. Redox reactions 3h 3h 4h 3h 3h 4h 2nd SEMESTER 1. Dunod. 3. Cours. Traduit de l’américain par G. Wulsberg – Théorie et applications. Cu(glycolate)2. H2SO3. Valentina Uivaroşi – Chimie anorganică. F. G: Marcu. 6. Hydrogen – preparation. Editura Medicală. Ionic polarization 11. 1999. Paris. Hangan. stability. Groups 1 and 2 – Elements and compounds – preparation and properties 2h Sodium. 1h 2. HNO3. Acid and base strength criteria and evaluation. phosphorus.oxides. Paris. Cluj-Napoca. 8. 6. cobalt. properties. 9. Editura Eikon. Chimie anorganică. L. Ellipses. Group 17 – The halogens Chlorine. H3AsO4 – and salts preparation. H2SO4.oxides. acids and salts – preparation and properties. Acids and bases. Bota. Victoria Aldea. Group 14 – Elements and compounds – preparation and properties Carbon. iodine. hydroxides. A. 3h Tin and lead – oxides. Precipitation reactions. H2S2O8 and salts. salts. magnesium. hydracids and salts. 6h Sulphur. Victoria Aldea. K3[Fe(C2O4)3]. Chromium and manganese – oxides. 7. Chemical equilibrium. Editura Medicală Universitară “Iuliu Haţieganu”. borax – preparation and properties 3h Aluminium – oxide. principii fundamentale. calcium. hydroxides and salts. Le Chatelier’s principle – applications 8. Hydrolysis reactions 10. General properties of acids and bases 9. 5. Iron. M. 2002. Bucureşti. H2S2O4. G. Noţiuni teoretice şi aplicaţii practice. H3PO2. 6h K[PbI3]. H3PO3.6. 5 . Group 13 – Elements and compounds – preparation and properties Boron – boric acid. 4. Reaction kinetics. 6h Antimony and bismuth – oxides. silicon – oxides. Descriptions des éléments. hydroxides and salts – preparation and 2h properties 12. hydroxides and salts – preparation and 3h properties 11. bromide. specific reactions Metal complexes preparation: [Cu(NH3)4]SO4. hydroxides and salts. 2004. sulphur acids: H2S. elemente şi combinaţii. 4. Metal complexes – preparation. Lefort – Les constituents chimiques de la matière. Editura Medicală. Rusu. H2S2O3. arsenic – compounds: ammonia. Boucekkine. H3AsO3. hydroxides and salts – preparation 2h and properties References 1. Copper and silver . salts. 2. W. 10. C. 12. Grecu. Neamţu. 16. M. Bucureşti. Wünsch. T.a. Bucureşti. Editura Didactică şi Pedagogică. K. L. 1994. Editura Junimea. Jacques Barbe . Traduit de l’anglais par André Pousse et Jean Fischer . Goina – Chimie anorganică. De Boeck & Larcier s. John J.A. Traduit de l’anglais par Paul Depovere .Chimie inorganique. Huheey.7. Enescu – Implicaţii biologice şi medicale ale chimie anorganice.-H. K. 18. Douglas. 1992 19. 3eme édition. Révision scientifique de Céline G. Tipografia UMF. Neamţu. 75116 Paris. Quarrie / Rock . Editura Tehnică.. Neniţescu – Chimie generală. 15. D.xhost. 2000. 49 rue Galilée.H. Grecu. Inc. De Boeck Wesmael. Alexander . L. 3d edition . Editura Poliam. P. Ghizdavu – Chimie bioanorganică. Shriver. Atkins. Zettler – Compendiu de chimie. 8.Chimie générale. Editions de Santé..D. Daniel. 14. 1996. Editura Didactică şi Pedagogică. 1982. M. De Boeck Université. Bucureşti. C.Chimie minerale raisonnée. Site: oprean. Editura All. 1996. Wiley – VCH 1997. Bucureşti. Sommer. Mc. 1998. Cowan . Darl H. L. 1982. J. 9. 2000. Şumălan – Chimie generală şi anorganică. s. Cluj – Napoca. 17.F.John Wiley & Sons. 13. Langford – Chimie anorganică (traducere din limba engleză). 11. Jung .ro/anorganica 6 . Bodie E.a. 1985. fascicula I.Inorganic biochemistry –an introduction. M.Concepts and models of inorganics chemistry. Keiter & Keiter . Iaşi. Bodoki E. 6. Acid-basic reactions in analysis 7. 7 . Redox reaction in analysis 2h 6h 2h 2h 2h 6h 4h 2h 2h PRACTICAL LESSONS SYLLABUS 1h Security safety in the laboratory 5h Preliminary reactions. S. 4. Vogel's Qualitative Inorganic Analysis.D. R. R. The object and the importance of analytical chemistry 2. Precipitation reactions 8. 1991. Water as solvent 5. 2. – Analiza Chimică Calitativă. Organic Chemistry TEACHING METHODES Lectures with Power Point presentations Laboratory practical works. L. 2.Oprean. Cecilia Cristea. G. Analytical classification of ions 3. Risoprint. Simona Mirel. 8.P. Complexing reactions 9. Essex. Systematic analysis of unknown samples (inorganic and organic ions) of pharmaceutical and biomedical interest PREREQUISITE – basic knowledge of General and inorganic Chemistry. ediţia a 6-a. 3. Longman Scientific & Technical. Analytical reagents 6. Chimie analitică calitativă. R. Chimie Analitică vol 1. Chemical balances in analyses 4. 1. 5. E. Ed.Săndulescu. 7.Săndulescu. English NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 42 hours (0/42) QUALITATIVE ANALYTICAL CHEMISTRY COURSE SYLLABUS 1.Lotrean.Roman. French. workshops on a given subject EVALUATION METHODES Periodic oral and written tests Final practical exam Final written and oral exam TEACHING LANGUAGE Romanian. 1999. 2007 3.CHAIR OF ANALYTICAL CHEMISTRY AND INSTRUMENTAL ANALYSIS COURSE TITLE – Qualitative analytical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire the principles of qualitative chemical analysis To perform qualitative analytical reactions.. (Fresenius) 6h Reactions for cations’ identification Analytical classification of anions (Bunsen) 6h Reactions for anion identification Systematic analysis 24 h Separation and identification of cations and anions Analysis of unknown salts (7 full analyses of mixtures containing between 2 and 6 inorganic or organic ions) References 1. Cluj-Napoca. Bucureşti. Svehla. Chimie des solutions. Guernet. M. 2003. Prognon. Cluj-Napoca. 5.Roman. 2007. 1976 . Hamon. R. Abrégé de chimie analytique. R. tome 1. Chimie analytique qualitative.Săndulescu. 1999 .Oprean. Paris. L. Mahuzier. Editura Medicală Universitară „Iuliu Haţieganu” Cluj-Napoca. M. M. Méthodes de séparation.4. P. Masson. Analyse Minerale Qualitative. Risoprint. Paris. Masson. D. R. Hamon. 7. Ed. 6. 3eme édition. Abrégé de chimie analytique. G. Ferrier. tome 2.Sandulescu. 8 . Cecilia Cristea. Enthalpies of Formation. Ion Conductivies. Standard States. The Calculation of Entropy Changes. The Clapeyron and Clausius-Clapeyron Equations. Extent of Reaction. Activity and Activity Coefficients. Debey-Hückel Laws. ELECTROCHEMISTRY Solutions of Electrolytes. The Gibbs-Helmholtz Equation. Standard Electrode Potentials. Applications of standard potentials Measurements. Electrode Processes. Calorimetry. Molar Conductivity. Ionic Mobilities and Diffusion Coefficients. The Measurement of Transport Numbers. Conditions for Equilibrium. The Nernst Equation.CHAIR OF PHYSICAL CHEMISTRY COURSE TITLE – Physical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES The students should acquire and apply the principles and methods of physical chemistry in different pharmaceutical disciplines. Chemical Equilibrium. Binary Systems Involving Vapour. The first principle of thermodynamics. Thermal Analysis. 2. 9 2h 2h 2h 4h 2h 6h . The second principle of thermodynamics. Activity Coefficients Measurements. Activity Coefficients. Temperature and Pressure Dependence of Equilibrium Constants. The Chemical Potential. Thermodynamics of Solutions. work and heat. Single-Component Systems. Phase equilibrium. Partial Molar Quantities. PREREQUISITE – knowledge of Physics. Ideal Solutions: Raoult's and Henry's Laws. Temperature Dependence of Enthalpies of Reaction. Chemical Equilibrium in Solution. Chemical thermodynamics Energy. Equilibrium Shift at Constant Temperature. Condensed Binary Systems. Biophysics and General chemistry TEACHING METHODS Lectures wit PowerPoint presentations Practical lessons EVALUATION METHODS Written examination and multiple choice questions (75% of the final grade) Practical exam (75% of the final grade) TEACHING LANGUAGE Romanian. Distribution of Solutes between non-miscible Solvents. Thermodynamic Equation of State. Relationship between U and H. Bond Enthalpies. The Colligative Properties. French. No ideal solutions. Molecular Interpretation. Osmotic Pressure. Measurement of Enthalpy and Internal Energy Changes. Boiling Point Elevation. Phase Recognition. Weak Electrolytes: The Arrhenius Theory. Transport Numbers. Gibbs Energies of Formation and Reaction. Debey-Hückel Theory. Tests for Chemical Equilibrium. Freezing Point Depression. Strong Electrolytes. Solubility and Distribution Phenomena. English NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 28 hours (0/28) PHYSICAL CHEMISTRY COURSE SYLLABUS 1. Ionic Mobilities. Thermochemistry. The Helmholtz and Gibbs energies. Phases and Solutions. Enthalpy and Entropy of Vaporization: Trouton's Rule. Vaporization and Vapour Pressure. Ternary Systems. Ostwald's Dilution Law. Karaman. Refractive index. A. Silvia Imre. First and Second Order Reactions. 2005 7. Determination of partition coefficient of a substance between two solvents 2h 10. Cluj Napoca. Alexander T. 2007 10 . Editura Casa Cărţii de Ştiinţă. Accelerated Stability Analysis. Repulsive and total interactions. Photochemical Reactions. John Wiley & Sons.. Martin. Determination of neutralization. Potential Energy Surfaces. Ionic Strength and Dielectric Constant on Rates. Reactions in Solution. Partial molar volumes 2h 4. Consecutive Elementary Reactions. Ludovic Kurunczi. Molar Polarization. Chimie Fizică. Curs de Chimie Fizică şi Coloidală pentru farmacişti. Calculation of the acidity constant of a weak acid by conductivity measurements 6.3. Emil Făgărăşan. J. Activated Complex Theory. Cryoscopy and micro cryoscopy. Peter Atkins. 2h 2. Relative permittivity. Calculation of osmotic and activity coefficients for diluted solutions 2h 5. Swarbrick. Cammarata. Applied Colloid and Surface Chemistry. Iuliu Marian. Effects of Solvent Polarity. Pashley. Influence of Temperature on Reaction Rates. Florence. Cluj Napoca. Marilyn E. 1983 5. A. 2002 2. Julio de Paula. References 1. Zero. Degradation and Stabilization of Pharmaceuticals. 2h 12. Explosions. Quantitative calculations in pharmaceutical practice. Oxford University Press. Pharmaceutical Press. Editura Mirton. Dan Rusu. Intermolecular forces. Applications of permittivity measurements. 2h 11. Problems and recapitulation. Philadelphia. Lea & Febiger. CHEMICAL KINETICS Rate and Order of Reaction. Spectrophotometric determination of the acidity constant of a weak acid in presence 2 h of an indicator 2h 7. Electrical properties of molecules. Specific Acid-Base Catalysis. 4.Elemente de termodinamică şi structură. Richard M. Debye and Clausius-Mossotti Equations. 2004 3. THE ELECTRIC AND MAGNETIC PROPERTIES OF MOLECULES Polarisability. Timişoara. Analysis of Kinetic Results. Experimental Techniques. Refraction index measurements applied to structure and purity determination and quantitative analysis 2h 9. 2h 8. Practical exam. Physicochemical Principles of Pharmacy. Physical Pharmacy-Physical Chemical Principles in the Pharmaceutical sciences. Magnetic susceptibility and magnetic moment. 2h 3. 2000 6. Physical Chemistry. 6h 4h PRACTICAL LESSONS SYLLABUS 6h 1. Collision Theory. Chimie Fizică experimentală. Reaction Rates and Equilibrium. David Attwood. Editura Medicală Universitară “Iuliu Haţieganu”. 2004 4. London. Free-Radical Reactions. Ltd. Interactions between dipoles. mixing and solvation enthalpy using calorimetric methods. cell division. and leaf. virtual botany (multimedia type) Practicals: Individual practice: microscopy (vegetal cytology. 4. pharmaceutical importance for root. The flower. Systematic botany: Botanical nomenclature. fruit and seed. anatomy. the biosynthesis of pharmacological substances. Procariobionta. Vegetal histology: Definition. fruit and seed 6 h as medicinal sources 2. parenchyma. structure. histology. lysosomes. 11 . anatomy). Physiology of the leaf: nutrition types. 22 h Cormobionta. conducting tissues. genera. plasmalemma. their biological role 15 h (hyaloplasma. 8 h secretory tissues 3. supporting tissues. students will learn how to manipulate the microscope. ultra structure and chemical composition. 2. Plant reproduction: Vegetative. Principal orders. vegetal tissues. Elements of cell physiology: permeability and absorption. Phycobionta. the photosynthesis. nucleus). primary and secondary 19 h structures. During practicals. 2nd SEMESTER 1. morphology. protection tissues. ribosomes. species with pharmaceutical importance of Cormobionta. variations of structure. PREREQUISITE – General botany knowledge (high school level) TEACHING METHODS Course: Lecture with Power point presentation. sexual and non sexual multiplication. chondriosomes. the structure and the ultra structure of cell organelles. organization of vegetative and reproductive apparatus in plants. Morphology and anatomy of the flower. Morphology and anatomy of vegetative organs: General characteristics of vegetative organs. plastids. Bryobionta. some systematic families of plants with pharmaceutical importance. Golgi apparatus. Meristems. endoplasmic reticulum. Origin. Subkingdoms Virobionta. superior plant determination. stem. differentiation and classification of plant tissues. Vegetal cytology: General organisation of vegetal cell. Mycobionta. Systematic units. its chemical composition. families. Paraplasmic content. how to recognise medicinal plants in order to avoid their substitution with other species without pharmaceutical activity. modified organs. medicinal plants from the department collection: study and recognition EVALUATION METHODS: Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical activities and written test) at the end of each semester (20% from final score) Multiple choice questions (MCQ) test at the end of each semester (80% from final score) TEACHING LANGUAGES: Romanian French English NUMBER OF HOURS Course – 70 hours (42/28) Practical lessons – 70 hours (42/28) PHARMACEUTICAL BOTANY COURSE SYLLABUS 1st SEMESTER 1.CHAIR OF PHARMACEUTICAL BOTANY COURSE TITLE – Pharmaceutical botany COURSE AND PRACTICAL LESSONS OBJECTIVES Knowledge accumulation regarding: cell organization. vol. Ed. Microscope manipulation. UMF Cluj-Napoca . Stefănescu Cristina. 2005 12 .Cormobionta). 2002 3. phloem). et Univ Romande. Univ. 2002 6. Superior plant determination. Laberche J. vol. supporting tissues (collenchyma. Dunod Paris. Roland J. vol. Leaf anatomy 3h 9h 9h 3h 6h 3h 9h 2nd SEMESTER 1. Crişan Gianina. Divisions Pteridophyta and Pinophyta 2h 3.: Biologie végétale. Cell division (mitosis). Spichiger R. Cellular plasmolysis 3. Balica Georgeta: Botanique pharmaceutique – La systématique. Guignard J. Roland Françoise: Biologie végétale. Crişan Gianina. 2. Ed. Lausanne. I (Citologia). Cell wall. Med. Med. Univ. et al. Ed. Med. III (Sistematica . Secondary structure of the root and stem 7. Univ. 1998 5. UMF Cluj-Napoca. watery tissue). Med. Masson Paris. Univ. 1999 7. microcrystals. Cuticula. Ed. 2005 9. Organisation des plantes à fleurs. Leaf morphology. fundamental tissues (air spaces. Tămaş. starch grains. Editura Medicală Universitară “Iuliu Haţieganu” ClujNapoca. secretory tissues 4. schlerenchyma). Inflorescences. II (Histologia) Ed. Primary structure of the stem and variations 6. the microscopy kit. Medicinal plants from division Magnoliophyta 18 h References 1. Tămaş M: Botanică farmaceutică. Ed.-L. UMF Cluj-Napoca.-E. Flower anatomy..PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. chromoplasts. Fruit morphology and 8 h classification 2. Dunod Paris. Tămaş M: Botanică farmaceutică. Ştefănescu Cristina: Botanică farmaceutică – Lucrări practice.-C. Pres. M. trichomes). The microscope. Protection tissues (stomata. Chloroplasts. Tămaş M: Botanică farmaceutică. Flower morphology.: Botanique. The structure of the vegetal cell. Pol. Primary structure of the root 5. Techniques for obtaining microscope slides 2. UMF Cluj-Napoca. conducting tissue (xylem. 2001 8. 2004 2.-C. 1999 4. Ed.: Botanique systématique des plantes a fleurs. I. Students should be able to perform some simple medical tests: determination of haematocrit. Conservation of the impulsion. pH meter. Conservation of kinetic moment. plasma proteins. Equation of Galilee. Work. chemical and biological systems. specific heat. Centrifugal force. electrophoresis. Dynamics The principles of Newtonian dynamics Forces.1. PREREQUISITE . English. Mechanics I.CHAIR OF PHYSICS-BIOPHYSICS COURSE TITLE – Pharmaceutical physics COURSE AND PRACTICAL LESSONS OBJECTIVES Course: to contribute to the scientific formation of the students in pharmacy by integrating knowledge and skills acquired in the discipline of Pharmaceutical Physics with the other basic subjects: Chemistry. Kinematics Kinematics of uniform accelerated movement. Cell Biology and Physiology. Potential energy.3. Students should acquire skills necessary to use laboratory equipment: electric equipment. refractive index. by establishing causal links (determinism) between different phenomena and processes. specific light rotation angle. spectroscopes. Kinetic energy. graphic representations. Kinematics of circular movement. Kinetic moment.4.2. conductivity meters. Practical classes aim that students can measure properties and physical constants of materials: the density of liquids and solids. I. radiation detectors. linear interpolation. viscosity coefficient. melting point. The course also aims to contribute to the formation of a scientific thinking of students by using models in the description of physical. Oscilloscopes. Impulsion. Power. Conservation of mechanical energy 8h 13 . boiling temperature surface tension coefficient. polarimeters.Knowledge of physics at high school level TEACHING METHODS Theoretical course: Plenary Lectures Practical Lessons: Individual and group experiments EVALUATION METHODS Theoretical course: Multiple choice or master examination Practical Classes: performance by the students of a real experiment TEACHING LANGUAGE Romanian. haemoglobin. Students should acquire specific skills in experimental measurements: errors calculation. spectrophotometers. Impulsion and kinetic moment. by verification of theoretical models based on experimental data. French NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 42 hours (42/0) PHARMACEUTICAL PHYSICS COURSE SYLLABUS 1st SEMESTER I. Applications I. and the isoelectric point of protein. Types of forces Dynamics of circular movement. Work and mechanic energy. Sounds. Radiations’ law. Transformations. Thermodynamic equilibrium. State equations. Transport phenomena. I. The theorem of Gauss.3. convection. Surface tension .2. Gas law. III. Conduction (Fourier). Transport through membranes. Entropy and disorder. Electric potential. I. State parameters.5. Classification of waves.9. Dulong-Petit law. The Carnot cycle. Diffusion. Pression formula. II. Thermodynamic system. Mechanics of solids. I. Applications. Free energy (Helmholtz). Far from equilibrium systems. Tensioactive substances. The law of Hooke. Composition of oscillations. The relation of Gibbs. Thermodynamics Fundamental notions. Classifications. Law of Bernoulli I. Internal energy. Condensers. Law of Laplace. Elastic and plastic deformations.Mecanics of fluids. The principle of Archimedes. Triple point. Infra et ultrasounds. Work and heat.4.6. Thermal phenomena 10 h II. Enthalpy. I.1. Non Newtonian bodies.1. Thermal state equation. Intensity. Thermodynamic potentials. Applications. Oscillations Harmonic oscillations. II. Viscometers. General equation of waves. Diffraction. Clausius Clapeyron equation. Conductors in electric field. II. Static of fluids. Electricity and magnetism 5h III. Rheology Law of Newton. Propagation. Phase transformations. Efficiency. The law of Pascal.7. Reflection and refraction Interference. Osmosis. Calorimetry. Newtonian liquids. First principle of thermodynamics. Colligative properties of solutions.I. Electric field. Gibbs free energy. Forced oscillations. Kinetic theory of gases. Doppler effect. Entropy and probability.8. Dispersion. Law of Coulomb. 14 . Second principle of thermodynamics. Viscosity. Electrostatics Electric charge. II. Osmotic work. Mechanical waves Equation of the plane wave. Melting and solidification.Capillarity.10. Fick’s equations. Entropy. Specific heat of solids. Phase rule. Heat transport. Zero law of thermodynamics. Fluids dynamics.Surface tension. Equations of oscillatory movement. Vaporisation and boiling. pH 8. Introduction. Electricity: -electrolysis. The laws of Kirchhoff. Types of radiations. Nuclear models. Applications IV. Artificial radioactivity. Optics 3h IV. Optics: . 42 h PRACTICAL LESSONS SYLLABUS 1. Electric energy. Power. Nuclear reaction. errors. Dipole moment.microscope. Magneton of Bohr. Viscometers 5. Electric lead. Electric circuit. Maxwell’s equations. Spectrophotometry. Spin of the electron.3. Magnetic properties of matter. Law of Ampere. Electrolysis III. Radiations doses. Electrons spin resonance. Optical microscope. 6. Lambert Beer law.Electric dipole. Electronic magnetic moments. Light as an electromagnetic wave. Law of Ohm (microscopic form). Classical conduction theory. 4. 2. characteristics. Radioactivity.lenses. 15 .3. . Isotopes. Applications. Lenses and mirrors. Photonic optics.nuclear magnetic resonance. Magnetic field. 3.1. Wave optics. Colorimetry. units. Surface tension.2. III. concentration cell. Electromagnetic induction. Law of Faraday. Biot-Savart law. Calorimetry 7. Photoelectric effect. -resistivity. -galvanic cell. Magnetic field of electric currents. IV. NMR. V. IV. Pair formation. Applications. Geometrical optics. physical quantities. Dipolar electric field. Compton effect. Magnetic resonance. Weighting methods. -conductometry. Interference and diffraction. Magnetic induction. Nuclear forces. -variation of resistivity with temperature. Light absorption Photometry Atomic and molecular spectra.2. Protection. Stationary electrical current. Nuclear physics 2h Atomic nucleus. Density determinations 4. IV. Polarisation of light. Disintegration laws. Balances. K. Romto. Ed. 1975 4. F.. 2000 2. Physique et Biophysique experimentales Editura Medicala Universitara “Iuliu Hatieganu” Cluj-Napoca. E. Ridgway. Biophysique. . D. Budapest 1994 6. R. Clarendon Press Oxford.polarimetry. C. 1974 5. . Halliday. Physical Pharmaceutics.spectrophotometry. Constantin Mihai Lucaciu . Detection of nuclear radiations (activity determinations. 2000 16 . 1982 3. gamma photon absorption) References 1. Flammarion Paris. colorimetry 9. Ed. Shottan. Fizica. Gremy. Methods of separation 10. Akademiai Kiado.M.refractometry.. Bucuresti. Resnick. Editura Medicala Universitara “Iuliu Hatieganu” Cluj-Napoca.Lucaciu. Fizica. G. Didactica si pedaqgogica. A Tarjan An introduction to Biophysics with medical orientation. Fizica si Elemente de Biofizica. Paris 1982 3. Human eye. C. Davier. the effects of environmental factors on biological systems. Dynamic muscle activity. Gremy. Physique pour les sciences de la vie. 5. Constantin Mihai Lucaciu “Transportul ionilor prin membranele biologice” Editura medicala Universitara “Iuliu Hatieganu” Cluj-Napoca. Students should be able to explain by the laws of physics the physiological and pathological processes that occur in biological systems. Sounds. Medical Applications 1h 6. Biophysique.Knowledge of physics and biology at high school level TEACHING METHODS Theoretical course: Plenary Lectures EVALUATION METHODS Theoretical course: Multiple choices or master examination TEACHING LANGUAGES Romanian.I. Energetica lumii vii. Infrared and ultrasound.CHAIR OF PHYSICS . Bucuresti. D-G. 3. Biomechanics 2. Ed. Bucuresti 1992 5. M. 1h 9. 1h 8. M.Isac. Belin. 4. Ed. Paris. Physical properties of 2 h lipids. Membrane models. Biophysics of blood circulation 1h 7. F. A. Muscle structure. 1988 4. Membrane proteins. Didactica si Pedagogica. Sensory Biophysics. Physiology. relationships that occur between the physical properties and biological role of organic molecules. Transmembrane generating potential. 2005 2. Margineanu. Flammarion. PREREQUISITE . B. Biofizica. Ed.BIOPHYSICS COURSE TITLE – Biophysics COURSE OBJECTIVES The aim of the course is to contribute to scientific training of students in pharmacy by integrating knowledge and skills acquired in the discipline of Pharmaceutical Physics to those acquired in the biological disciplines. D-G Margineanu. The structure of cell membranes. and French NUMBER OF HOURS Course – 14 hours (0/14) BIOPHYSICS COURSE SYLABUS 2h 1. Edimpex-Speranta. References 1. 3 h Transport through oligopeptides and proteins. Nernst-Planck equation Resting potential Action Potential Propagation of action potential. Weber Fechner law. The mechanism of muscle contraction. English. Bouyyssy. Ed. Osmosis. Membrane transport. Bioelectricity 3h 10.Tarba. Passive transport through lipid bilayer. the Biophysics aims to contribute to scientific training pharmacy students in integrating knowledge and skills acquired in the discipline of Pharmaceutical Sciences with other basic subjects: Chemistry. Active transport. Cell Biology. Medical applications Biophysics methods to study of transport systems. 1980 17 . Gantz. Lot of numbers and algebraic structures 1. Notions of algebra 1. To exercise computational methods for implementing mathematical and statistical calculations related to specific subjects of the course. Internet site for students: http://www. TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 42 hours (28/14) Practical lessons – 56 hours (28/28) BIOMATHEMATICS AND BIOSTATISTICS COURSE SYLLABUS Biological mathematics 1.4. Fourier series 4.1. Improper integral 5.html EVALUATION METHODS Continuous assessment based on performances in practical lessons.3.umfcluj.1.4.3. The study of a real function in one real variable 3. Limits. Vector spaces. Operations with vectors 1.3. Differential Equations 5. implementation of calculations using specialized programs.2.2. Strings and series 3. differentiability 2. Determinants 1. Integral calculus 4. Real basic common features. Numerical series 18.104.22.168. Differential Equations of first order 5. Taylor's formula 2. Real basic functions 2. Primitives 4. Differential equations of higher order 18 3h 3h 4h 4h 4h . project based assessment.1. Series of functions 3.1. Matrix calculation 1. PREREQUISITE – knowledge of mathematics at high school level TEACHING METHODS Course: Lectures with PowerPoint presentations and demonstrations of computational calculation Practical lessons: demonstrations in the classroom.ro/depts/MI/index.farma.2.5. Eigenvalues and eigenvectors 2. Fully defined 4. Series 3.4. multiple choice examination.CHAIR OF MATHEMATICS AND INFORMATICS COURSE TITLE – Biomathematics and Biostatistics COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire the instruments and the mathematical and statistical methods useful for deterministic and probabilistic modelling of certain problems specific for pharmaceutical sciences. continuity.1. 2. Indicators of centrality 4. Discrete random variable 22.214.171.124.4.5. Probabilities 1.reality. Bayesian forecast 5. The construction of a mathematical model 8. Classical mathematical models 8. Mathematical modelling and simulation 8. The approximate calculation of derivatives 7.4. Simulation 4h 4h 2h Biostatistics 2 SEMESTER 1. The approximate calculation of defined integrals 7.4. differentiability for functions with several variables. Methods of interpolation 7. Differentials 6. Organization of statistical data 4. Characterization of common distributions 5. Bayes' theorem 1. Expanding notions of limit.3.2. Defining the real functions of several real variables 6. Description of areas by function of several variables 6.3. Parametric correlation 6. Continuous random variable 2.1. Applications.2. Laws of random variables distribution Bernoulli distribution Binomial distribution Poisson distribution Uniform distribution Normal distribution 3.2.4. Method of maximum likelihood 5. Estimator 5. Correlation and regression 6. The relationship model . Differential equations with restrictions 6. Total and conditioned probabilities 1.1. The smallest square method.3. Descriptive Statistics 4.1.2. The accuracy of models 8. Multidimensional spaces 6. Classical formula of probability 1.6. Real functions with more than one real variable 6.4. Sampling Statistic population and sample Methods of sampling The sampling size Representative samples 4. Numerical solving of equations 126.96.36.199.3.2. Events.1. Estimates 5. 6. Propagation of errors 7.4.3. Partial correlation 19 1h nd 1h 2h 2h 2h 2h . Indicators of variation 4. Numerical Methods 7. continuity.2. MCMC method (Markov chain Monte-Carlo) 6.3.5. Tests for comparing two groups of pairs 7. Nonparametric methods 8. Statistical methods for intensive calculation References 1. Testing of statistical hypothesis 7.1. R.3. S.1. Tests for comparing a group with the reference values 7.4. Paris.3. Bootstrap re-sampling 9.3. 2002 3. Biomathematique et Biostatistique. Presa Universitara Clujeana. Tests for comparing more than two groups 8. Biomatematica.5. Jackknife re-sampling 9. Mason. Numerical Methods 8. Prodan. Laws of random variables distribution 3. Differential Equations 6. Tests for comparing two independent groups 7. aplicatii in Excel 3h 4h 3h 3h 3h 3h 3h 3h 3h 20 . R.4. Notions of algebra 2.4. Trimbitas. A. Estimates 6. Nonparametric tests for comparing independent groups 8. Integral calculus 5. Series 4. Probabilities 2. Prediction by regression functions 7. Regression Analysis 6. Metode Statistice. Benazeth. Sampling 4. Nonparametric Correlation 9.6.1. Nonparametric tests for comparing groups pairs 8. Real basic functions 3.2. 2000 2. Real functions with more than one real variable 7. Correlation and regression 7. Mathematical modelling and simulation 3h 4h 4h 4h 4h 3h 3h 3h 2nd SEMESTER Implementation using Excel statistical functions package of statistical calculations specific for the following chapters 1. Nonparametric methods 9. Cimpean.2. Descriptive Statistics 5. Cross-Validation PRACTICAL LESSONS SYLLABUS 2h 1h 1h 1st SEMESTER Implementation using Excel mathematical functions package of mathematical problems specific for the following chapters 1.2. Nonparametric tests for comparing more than two group 8. Multiple regression 6. Statistical methods for intensive calculation 9. Testing of statistical hypothesis 8.3. CHAIR OF MATHEMATICS AND INFORMATICS COURSE TITILE – General informatics COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire the essential IT skills for computer use in pharmacy. PREREQUISITE – general knowledge of informatics at high school level TEACHING METHODS PowerPoint presentations, Conversations Laboratory works, Exercises, Applied experiments, Case studies. Projects Computer based modelling and simulation EVALUATION METHODS Periodic evaluation Project evaluation Electronic portfolios Final exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (14/0) Practical lessons – 28 hours (28/0) GENERAL INFORMATICS COURSE SYLLABUS 1st SEMESTER 1. Introduction 1h General information about computers. Hardware and software. Operating systems and applications. GUI (Graphical User Interface). Computers network. Internet. Internet services (e-mail, FTP, World Wide Web, telnet). Microsoft Office: Word, Excel, PowerPoint, Outlook, FrontPage, Access. Text Processor for pure text: Notepad. Formatted text. 2. Text Processor Word 2h Word document. Creation and management. Character formatting (font, font size, font style, colour, etc.). Text formatting (alignment, spacing and indentation). Bullets and numbering. Arranging a text on columns. Tab stops. Tables. 3. Excel 2h Excel documents. Working with spreadsheets in workbook. Working with formulae and functions in Excel l. Relative and absolute addresses Making graphics associated with spreadsheets. Databases in Excel Subtotals in Excel. Pivot tables and pivot charts. 21 External references in Excel. Statistical processing in Excel. 4. PowerPoint Presentations. Creation and management of a presentation. Creation of new slides. Insert images and other objects. Animation. Print of a presentation. Visualization of a presentation. Reordering of the slides in a presentation. 5. Databases in Access 6. FrontPage Creating a Web page using FrontPage. Inserting hyperlinks. Adding images and other objects. 7. Resources on Internet 8. Revision PRACTICAL LESSONS SYLLABUS 2h 2h 2h 2h 1h 1st SEMESTER 1. General information about computers. Hardware and software. Operating 3 h systems and applications. GUI (Graphical User Interface). Internet services (email, FTP, World Wide Web, telnet). 4h 2. Text Processor Word 4h 3. Excel 4h 4. PowerPoint 4h 5. Databases in Access 3h 6. FrontPage 3h 7. Resources on Internet 3h 8. Revision References 1. Mihai Prodan, Augustin Prodan – Microsoft Office XP pas cu pas, Editura Albastra (Microinformatica Group), Cluj-Napoca, 2002, ISBN 973-650-080-2. 2. A. Prodan, F. Gorunescu, M. Gorunescu – Excel, Access si Pagini Web, Editura Albastra (Microinformatica Group), Cluj-Napoca, 2006, ISBN 973-650-190-6. 3. Mădălina Rusu, Augustin Prodan – Informatică generală pentru studenţii Facultăţii de Farmacie, Editura Clusium, Cluj-Napoca, 2005, ISBN 973-555-489-5. 4. Remus Câmpean, Augustin Prodan – Biomatematică, Aplicaţii în Excel, Ed. Medicală Universitară Iuliu Haţieganu, Cluj-Napoca, 2003, ISBN 973-693-016-5. 22 CHAIR OF PHARMACEUTICAL LEGISLATION COURSE TITILE – Introduction to pharmaceutical technology and legislation (IPhTL) COURSE OBJECTIVES The aim of the course is the initiation of the students in the pharmaceutical science, for the first year practice in pharmacy. The objectives of the course are to teach the students the introductory pharmaceutical notions and to help them to understand the importance of pharmaceutical profession. PREREQUISITE – general high school knowledge TEACHING METHODS Lectures with PowerPoint presentations The students receive the course support on the paper or in electronic format. EVALUATION METHODS Writing examination: multiple choice questions TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (0/14) INTRODUCTION TO PHARMACEUTICAL TECHNOLOGY AND LEGISLATION (IPHTL) COURSE SYLLABUS 1. Definition of the discipline, objectives, importance for the first year students 2h 2. Definition of pharmacy: profession, societies. 2h 3. Exercise of pharmacy: the law, the code of ethics. 2h 4. Pharmaceutical societies and activities of the pharmacist 2h 5. Medicine: definition, classification, compounds. 2h 6. Prescription: definition, parts, types of medical prescriptions. 2h 7. The relationship between pharmacist and patient: communication, services. 2h References 1. Aiache J.M., Initiation à la connaissance du médicament, Lavoisier, 1986, 2001 2. Appelbe G.E, Wingfield J., Pharmacy Law and Ethics, The Pharmaceutical Press, London 1997; 3. Belon J.-P., Conseil à l’officine, Masson, Paris, 2000; 5. Code de la Santé Publique, www.legifrance.gouv.fr; 6. Codul deontologic al farmacistului, Monitorul Oficial al României nr. 490/2009; 4. Kelly W., Pharmacy. What it is and how it Works, CRC Press Pharmacy Education Series, 2002; 7. Legea nr. 95/2006 privind reforma în domeniul sănătăţii, Monitorul Oficial al României nr. 372/2006. 23 popular science and non-specialist articles). through employing lexical. Linking words (Connectors). Scanning long and difficult texts. Curriculum Vitae. class activity. Skimming for summarizing. the practical course also contributes to the development of the students’ teamwork skills. Describing people. developing reading speed). skimming in order to extract the main idea(s). morphological and discourse analysis elements as well as through the identification of text structure and conventional format. Specific objectives include: . 2 hours 2. conversation on professional topics.The development of writing skills through the analysis of text rhetoric (scientific research articles. Through pair work or group work activities. The main objective is the development of specific communication skills.The development of the other three basic language skills: reading (active and intensive reading of specialized texts. case presentations. Rearranging paragraphs according to internal logic 2 hours Writing skills 1. summaries. oral communication (situational communication. Reconstructing sentences and paragraphs based on discourse logic 24 6h 14 h . 2 hours 4. paper and poster presentations). and listening (understanding and making use of the information in a spoken text). formal letters (representing 50% of the final mark) TEACHING LANGUAGE English/Romanian NUMBER OF HOURS Seminaries – 56 hours (28/28) ROMANIAN LANGUAGE COURSE SYLLABUS Reading skills 1. scanning for specific information. essay. PREREQUISITE: none TEACHING METHODS Communicative method Integration of the four basic language skills EVALUATION METHODS Written and oral examination (representing 25%+25%=50% of the final mark). . Describing objects and their use 2 hours 3. 2 hours 3.CHAIR OF MODERN AND APPLIED LANGUAGES COURSE TITLE – A Practical Course in Romanian (for foreign students) for Pharmacy COURSE OBJECTIVES The practical course is aimed at ensuring the acquisition of modern language knowledge and skills that students may use both in a general as well as in a specialised context related to their future profession. course books. summarizing parts of a text 2 hours 2. Dividing a text into paragraphs. including portfolio. Completing forms. 25 . 2 hours 4.. Role-play. Listening for gist. editia a IV-a. Giving instructions. Universitatii din Bucuresti. Fotea. Gramatica limbii romane. Ed. Narratives 2 hours Listening skills 8h 1. in diagrams). 2 hours 4. Institutul European. Writing formal and informal letters. editia a III-a. D. Writing a Curriculum Vitae (resume) 2 hours 7. Saramandu Mariana.. Echinox. 2003 4. 2 hours 5. Facts and opinions. 2 hours Speaking skills 14 h 1. Manual pentru studentii straini. A. Listening for specific information. Limba romana de baza. Limba Romana. Note taking. Oral presentation skills. Iasi. Dorobat. Romana cu sau fara profesor. Ed.. Expressing agreement or disagreement. Intensive listening. 1996 3. Pop. Echinox.2 hours Presenting pros and cons on a given topic 2 hours 6. 2 hours 3. Understanding a lecture or a conference. Liana. Listening and information Transfer (in written form.. Bejan. Ed. Ionescu Adriana. M. Cluj. G. Brancus. Cluj. 2 hours 2. 2 hours 3. Structure of the pharmacist-client dialogue. Explaining. 2 hours References 1. Ed. 2 hours 2. 2001 2. Comparing information from different sources. editia a V-a. 1999 5. Advantages and disadvantages. To prevent and correct deficient attitudes and to recover after traumatic sequels following certain illnesses. Exercises for the prevention of deficient attitudes or organic deficiencies due to the specificity of professional activity. To correctly form a development system and motrice principles (basic and used in certain sport disciplines). volley-ball. Theoretical and practical elements for physical self-education. Jogging. PREREQUISITE TEACHING METHODS Physical exercises EVALUATION METHODS Practical examination TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Practicals: 56 hours (28/28) SPORT Perform several practical activities necessary for the consolidation of technical and tactical precepts specific for individual and collective sports. 26 . suppleness. table tennis. tennis. coordination skills. To develop the skills needed to acquire a systematic practice of physical exercises. as a component of a healthy life-style. Initiation in the practice of a game: basket. Massage and self-massage gestures. resistance. Perform practical activities necessary for the development of basic motrice qualities. Perform specific activities necessary for a systematic individual practice of physical activities. football. Diversify physical education and sport activities according to students’ choice and to individual biometric configuration (individual physical condition). Aerobics. Exercises for the development of motrice qualities: force detente. To develop basic motrice qualities as well as specific qualities necessary for different sports. badminton. Fitness.CHAIR OF SPORT COURSE TITLE – Sport COURSE OBJECTIVES To maintain an optimum physical condition. speed. To contribute to growing process and to favour a normal physical development. Exercises for learning technical gymnastic and athletisme elements. To develop qualities and voluntary and moral characteristics and to stimulate the esthetical sense and social responsibilities. Editura Medicală. use and maintenance. Botany. under the coordination. measuring. Memomed. Nomenclatorul de medicamente şi produse medicamentoase de uz uman.CHAIR OF MEDICAL DEVICES COURSE TITLE – Summer practice for the 1st year students in pharmacy OBJECTIVES OF THE PRACTICE initiation work in a pharmacy (community pharmacy.2 weeks (0/60) SUMMER PRACTICE FOR THE 1ST YEAR STUDENTS IN PHARMACY SYLLABUS 1. Compliance with internal regulation 3. 3. Agenda medicală. * 30 hours /week – 2 weeks References 1. the destination of each room. 5. 1993 2. plan. Designation of the workplace: location. 2008 3. Chemistry TEACHING METHODS The application of theoretical knowledge acquired during the first year in pharmacy practice. Laboratory glassware. analysis on how to solve professional problems EVALUATION METHODS Characterization of student’s work by the tutoring pharmacist regarding: 1. responsibility and obligations of the pharmaceutical profession PREREQUISITE . Agenţia Naţională a Medicamentului. Editura Minesan. Knowledge of medicinal herbal teas: composition. The basic operations of pharmacy practice: weighing. packaging: description. X. tools. monitoring and verification of a pharmacist as tutor Explanations. 2008 27 . The attitude towards the staff in the pharmacy Filling the practice notebook Oral exam TEACHING LANGUAGE Romanian language French and English language for foreign students that perform the traineeship in their own country NUMNER OF HOURS 30 hours / week . Ed. Editura Medicală. discussions. spraying. Bucureşti. Bucureşti. Bucureşti. therapeutic use.IPhTL. Involvement in the pharmacy activity 4. 4. Farmacopeea română. homogenization. Bucureşti. 2. Frequency 2. hospital pharmacy) knowledge of pharmacy organization understanding the role. Performing division of some pharmaceutical specialties. 2008 4. Physics. Complexon III).General and inorganic Chemistry. Other methods (Nitritometry. 2.CHAIR OF ANALYTICAL CHEMISTRY AND INSTRUMENTAL ANALYSIS COURSE TITLE – Quantitative analytical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES Principles of quantitative analytical chemistry. Na2S2O3. I2. Qualitative analytical chemistry. workshops on a given subject EVALUATION METHODS Periodical oral and written tests Final practical exam Final written and oral exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 42 hours (42/0) QUANTITATIVE ANALYTICAL CHEMISTRY COURSE SYLLABUS 1. Acid-Basic Volumetry in Non-Aqueous Medium 8. Presenting the Analytical Results 5. HCl. K2Cr2O7. Protometric methods used for pharmaceutical and biomedical analysis in aqueous media (strong acids. Cu. Hg(NO3)2. Introduction. Statistics TEACHING METHODS Lectures with Power Point presentations Laboratory practical works. General issues in volumetric analysis 6.1 N volumetric solutions ((NaOH. alkaline bromates. Volumetry by Precipitation Reactions 10. Redoxometric methods for pharmaceutical and biomedical analysis (alkaline oxalates. ascorbic acid. PREREQUISITE . KMnO4. AgNO3. Taking Samples for Analysis 3. Organic Chemistry. preparation and titration of 0. iodine. strong basis. Argentometric titration of chloride (Mohr method). HIN. weighing by analytical balance. thymole. veronal with sodium methoxide in methanol-benzene) 3. NH3. Titration exercises. glycocol. Quantitative Analysis and Its Problems 2. Mercurimetry) 12. Fe(II) 4. boric acid. bromide (Volhard method) and iodide (Fajans method) 28 2h 2h 2h 2h 4h 2h 4h 2h 1h 2h 1h 4h 6h 6h 12 h 6h . Redox Volumetry 9. Gravimetric Methods PRACTICAL LESSONS SYLLABUS 1. Acid-Basic Volumetry in Aqueous Medium 7. Methods of quantitative analysis. NaHCO3 and non aqueous media (medinal with HClO4 in acetic acid. reduced Fe. Errors in quantitative analysis. Complexonometry 11. H2O2. Dissolving the Sample 4. NH4SCN. KBrO3. acetylsalicylic acid. Validarea metodelor analitice.Bojiţă. Méthodes spectrales et analyse organique. Bucureşti. R. 2. L. 9. Abrégé de chimie analytique. M. Nitritometric determination of p-aminobenzoic acid. M. I2. Mg – complexonometry. Gravimetric determination of Fe2+ from Mohr salt References 1. D. 3h 7. 4. Abrégé de chimie analytique.5. Mg(II). Ferrier. Editura Medicală. Masson. P. Paris. Fe(III) and Ni(II). Complexonometric determination of Bi(III). Ca. – Analiza Chimică Cantitativă E.Săndulescu. G. Mahuzier. 8. Masson. tome 1. Chimie Analitică vol 2.Săndulescu. Méthodes de séparation. General principles in gravimetric analysis. 3eme édition. tome 3. M. Hamon. Complex samples determination without separation of components (Bi. 5. Abrégé de chimie analytique. 3. Hamon. M. Paris. Prognon. tome 2. 1999 . 1976.Roman. I-). Masson. M. Ca(II). 6 h determination of water hardness. Guernet. 3h 6. Bucureşti. M.Roman. Chimie des solutions. G. Guernet. L. 2007.P. 2eme édition. 1990 29 . 1999. Mahuzier. Pellerin. Hamon. F. Mercurymetric determination of chloride and iodide (Cl-. Daniela Muntean. Paris. R.D. KI – iodometry and argentometry). Determination by extraction and TLC of some metallic dithizonates 2. EPR 9. Hyphenated Methods 10. at normal pressure of a cation mixture 5. Potentiometric determination of strong bases with strong acids 8. Colorimetric and potentiometric determination of pH 7. Ferrous/ferric cyanide system study by cyclic voltammetry 30 . Mass Spectrophotometry 8. Statistics TEACHING METHODS Lectures with Power Point presentations Laboratory practical works. Introduction 2. Problems in Trace Analysis 3. Chromatographic Methods of Analysis 5. Conductometric titration of weak and strong acids with strong bases 9. Conductometric titration of barium by precipitation reactions 10. Nuclear Magnetic Resonance. Qualitative and quantitative analytical chemistry. Separation and identification by TLC of some mixtures of anions and indicators 3. Electrophoresis separation on paper of some cation mixtures 6. Electroanalytical Methods 6. Contamination of Samples and Loosing of Some Components 4. Method validation Main separation and instrumental methods applied in pharmaceutical and biomedical analysis PREREQUISITE – General and inorganic chemistry. Voltamperometric determination of ascorbic acid.CHAIR OF ANALYTICAL CHEMISTRY AND INSTRUMENTAL ANALYSIS COURSE TITLE – Separation methods and instrumental analysis COURSE AND PRACTICAL LESSON OBJECTIVES Separation methods frequently used in chemical analysis. Validation of Analytical Methods 2h 2h 2h 8h 4h 4h 2h 1h 1h 2h 3h 3h 3h 3h 3h 3h 3h 3h 3h 3h PRACTICAL LESSONS SYLLABUS 1. workshops on a given subject EVALUATION METHODS Periodical oral and written tests Final practical exam Final written and oral exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 42 hours (0/42) SEPARATION METHODS AND INSTRUMENTAL ANALYSIS COURSE SYLLABUS 1. Separation by ion exchange chromatography on column. Instrumental methods of analysis. Separation and identification by paper chromatography of some mixtures of cations and thioureea derivatives 4. Optical Methods of Analysis 7. Physics. Organic chemistry. D. 1999. P. Paris. Abrégé de chimie analytique. 1999.Roman. F. Guernet. Editura Medicală. M. Nieman. Timothy A. Pellerin. De Boeck. M. James Holler. Masson. HPLC separation of some caffeine. R.P. Guernet. Douglas A. 2007. Photocolorimetric determination of Fe (II) with o-phenantroline 3h 12. F. Mahuzier. Bucureşti. – Analiza Chimică Cantitativă E. Daniela Muntean. Prognon. Paris. Ferrier. Chimie Analitică vol 3. G. Ière Edition. Skoog.Bojiţă. 2eme édition. Abrégé de chimie analytique. 2. Spectrophotometric determination in the visible light of some binary mixtures 3h (KMnO4 and K2Cr2O7) 14. 3eme édition. 3. Bucureşti. M.11. Ed. Spectrophotometric determination in ultraviolet light of ephedrine hydrochloride 3 h 13. Méthodes de séparation.Săndulescu.Roman. Paris. Validarea metodelor analitice. M. Méthodes spectrales et analyse organique. tome 2. Chimie des solutions. 4. L. R. 1976. Hamon.D. theobromine and theophylline mixtures 3h References 1. G. 1990 6. Hamon. M. Hamon.Săndulescu. 5. Masson. M. tome 3. Mahuzier. Masson. Abrégé de chimie analytique. Principes d'analyse instrumentale. L. 2004 31 . tome 1. CHAIR OF ORGANIC CHEMISTRY COURSE TITLE – Organic chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES Course: Acquiring organic chemistry knowledge necessary for learning and understanding informations taught in speciality disciplines Formation for a logical manner of thinking, based on analysis and synthesis Practical lessons: Acquiring knowledge and practical skills useful for the activity in other laboratories as well as for the practical activity of future pharmacists Understanding the relationship between the structure of a compound and its properties and the chemical activity Highlighting the importance of organic synthesis in obtaining bioactive compounds with pharmaceutical importance. PREREQUISITE Theoretical knowledge of organic chemistry form high school regarding the nomenclature, structure, synthesis methods and properties of the main classes of organic compounds; Theoretical and practical knowledge acquired during practical lessons and courses during the first year of faculty. TEACHING METHODS Interactive lectures; Practical activity in the laboratory; Discussions based on theoretical knowledge with the aim of solving practical problems. EVALUATION METHODS Practical exam; Theoretical exam; Evaluation of the practical lessons notes; Evaluation of the theoretical and practical knowledge during the semester TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 84 hours (42/42) Practical lessons – 84 hours (42/42) ORGANIC CHEMISTRY COURSE SYLLABUS 1st SEMESTER 1. General organic chemistry The aim and the development of organic chemistry as a science and its 9 h importance for pharmacy Structure of organic compounds: constitutional isomers and stereoisomers Structure of organic compounds: the influence between atoms in the molecule, electronic effects. Acids and bases in organic chemistry Organic reactions, reaction mechanisms, intermediates of reaction, factors influencing reaction rates, the role of solvent and catalysts in organic reactions Relations between structure and physical properties of organic compounds Nomenclature of organic compounds, nomenclature of compounds of pharmaceutical interests 32 2. Saturated, unsaturated and aromatic hydrocarbons 3. Organic compounds with simple functional groups Halogenated compounds Organometallic compounds Alcohols, enols, phenols, ethers and inorganic esters Organic compounds with sulphur 2nd SEMESTER 1. Organic compounds with simple functional groups Aldehydes and cetones Carboxylic acids and carboxylic acid derivatives: acyl halides, acid anhydrides, esters, amides, hydrazides, nitriles Organic compounds with nitrogen: nitroderivatives, nitrozoderivatives, amines, hydrazinoderivatives, quaternary ammonium salts, diazoderivatives 2. Organic compounds with mixed functions Halogenoalcohols Hydroxycarboxylic acids, aldehydoacids and ketoacids Hydroxyaldehydes and hydroxyketones Saccharides Amino alcohols Amino acids, peptides, proteins 3. Isoprenoids: terpens and terpenoids, carotenoids, steroids 4. Heterocyclic compounds General, nomenclature Heterocyclic compounds with five atom rings Heterocyclic compounds with six and seven atom rings Heterocyclic compounds. Bicyclic and polycyclic systems PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. Isolations and purification methods for organic liquid and solid compounds 2. Qualitative and quantitative elemental organic analysis Qualitative elemental organic analysis Quantitative elemental organic analysis 3. Synthesis methods and functional analysis for the most important functional groups Unsaturated hydrocarbons Aromatic hydrocarbons Halogenated compounds Organic compounds with hydroxylic groups: monohydroxylic and polyhydroxylic, énols, phenols Thiols Aldehydes and ketones 2nd SEMESTER 1. Synthesis methods and functional analysis for the most important functional groups Carboxylic acids and carboxylic derivatives Amines Diazonium salts Organic bifunctional compounds: saccharides, aminoacides Heterocycles 2. Elemental and functional analysis for some unknown samples 33 9h 24 h 21 h 9h 2h 10 h 6h 6h 30 h 27 h 15 h Observation: The aim of laboratory practice is to introduce functional groups in a molecule. The compounds obtained are isolated and purified, than they are identified by chemical reactions and by spectral methods (IR, UV-VIS, NMR, MS). We also study the identification reactions and characterisation for the most important functional groups in organic chemistry. References for the course 1. I. Simiti, Compuşi heterociclici 1984, Litografia U.M.F. Cluj-Napoca 2. C. D. Neniţescu, Chimie organică I şi II Ed. Did. şi Ped. Bucureşti, 1980 3. T.W.G. Solomons, Organic Chemistry, 6th edition, John Willey and sons, 1996 4. M. Miocque, C. Combet Farnoux, H. Moskowitz, Chimie organique, Tom 1, Masson, Paris, Milan, Barcelona, 5e édition, 1999 5. M. Miocque, C. Combet Farnoux, H. Moskowitz, Chimie organique, Tom 2, Masson, Paris, Milan, Barcelona, 3e édition, 1990 6. I. Simiti, V. Zaharia, Produşi naturali, Ed. Dacia, Cluj-Napoca, 1996 7. I. Simiti, V.Zaharia, Ana Mureşan, O. Crişan, Produşi naturali heterociclici, Ed. Dacia, Cluj-Napoca, 1998 References for practicals 1. V. Zaharia, Chimie organică experimentală, vol. 1, Editura Medicală Universitară „Iuliu Haţieganu”, Cluj-Napoca, 2003 2. V. Zaharia, Chimie organique expérimentale, vol. 1, Editura Medicală Universitară „Iuliu Haţieganu”, Cluj-Napoca, 2007 3. O. Crişan, Adriana Ignat, Synthèse organique de laboratoire, Editura Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca, 2007 4. S. Mager, Adriana Donea, I. Hopârtean, A. Benko: Lucrări practice de Chimie organică, vol. I, Universitatea Babeş-Bolyai, Facultatea de Chimie şi Chimie Industrială, 1990 5. S. Mager, Adriana Donea, I. Hopârtean, A. Benko: Lucrări practice de Chimie organică, vol. II, Universitatea Babeş-Bolyai, Facultatea de Chimie şi Chimie industrială, 1991 6. S. Mager: Analiza structurală organică, Ed. Stiinţifică şi Enciclopedică, Bucureşti, 1979 7. Margareta Avram, Gh. Mateescu: Spectroscopia în infraroşu. Aplicaţii în Chimia Organică, Bucureşti, 1966 8. I. Pogany, M. Banciu: Metode fizice în Chimia organică, Ed. Stiinţifică, Bucureşti, 1972 9. Heinz Becker and colab.: Organicum, Berlin, 1978 (Traducere Bucureşti 1982) 10. Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory, Third Edition, John Witley and Sons, 1994 34 Peptides. methods of study. drug-design). classification. Implications concerning drugs. essays Practical and written exams at the end of each term. toxicity. genetics TEACHING METHODS Interactive courses (specially during the 2nd sem. Hydro. Nucleosides and nucleotides. function. Specificity of enzymatic catalysis. sequence and purification. Threedimensional structure: models of secondary and tertiary structure. Organic enzymatic cofactors. importance concerning the drug.and liposoluble vitamins: structure. anatomy.CHAIR OF PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE TITLE – Pharmaceutical biochemistry and clinical laboratory COURSE AND PRACTICAL LESSONS OBJECTIVES Accumulation of theoretical and practical knowledge indispensable for the bio-medical formation of the pharmacist. circulation. 2. Quaternary structure. Enzymes. enzymotherapy. structure and role. Significance for pharmaceutical teaching curricula. isoenzymes. physiology. absorption. elimination. TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 42 hours (0/42) PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE SYLLABUS 1. nomenclature. 5. therapeutic implications. Molecular mechanism of action.organic and analytical chemistry. structure. Regulation by covalent modulations. distribution. 4. Kinetic properties.) based on video projection (animated Power Point) EVALUATION METHODS seminars. Fibrous proteins: collagen fibrils. Structural and functional diversity of proteins. Vitamins. 1h 2h 13 h 6h 6h 35 . Determinism of three-dimensional structure. Allosteric enzymes. PREREQUISITE . Chemical composition of bio-systems. biological significance. 3. Structural properties: catalytic centre. The denaturation phenomenon. Primary structure. prospecting. bio-transformations. Turnover and activity regulation. functional consequences. cell biology. Definition. biochemical role. Immunoglobulins. Role of metals in enzymatic catalysis. notion of domain (levels of structure in protein architecture). Object of the discipline. Proteins: structure and function. significance in pharmacotherapy. General aspects. utility in immunochemistry. Nucleotides. Superior levels of organization. enzymatic diagnostic. sources. deficiency characteristics. Biomedical importance. structure and biosynthesis. antagonists. Introduction in the study of biochemistry. Peptide synthesis by biotechnology and chemical methods. Amino-acids. deciphering of the molecular bases necessary for studying the drug (action. Enzyme inhibitors. modern aspects. Isolation. Ileana Olteanu. Dacia. 3rd Ed.. 6. KG. Căi fundamentale în metabolismul uman. John W. Maria Dronca. vol I. Gel-filtration. Biochimie structurale et metabolique. Christian Moussard. Ileana Olteanu. Exam 3h References 1. Noţiuni de biochimie clinică. England. KE. marker components. Inc. Biochimie structurală şi metabolică.. ClujNapoca. 1995. "Iuliu Haţieganu". 5.C. Medical biochemistry. Brown Publishers. DE. 2005. Biochimie descriptivă. Zubay. 2002. 5. General standards in enzymatic quantitative determinations. Vance. Colour and precipitation reactions for amino-acids and proteins in analytical 9h qualitative and quantitative biochemistry. Principles of Biochemistry. 3h 8. Experimental determination of kinetic parameters of Michaelian enzymes. 12. Universitară "Iuliu Haţieganu". Determination of specific activity. Bucureşti. 6. WW. 2008. Harlow. CK. Ileana Olteanu. 7. Cellular fractioning. Ed.. Univ. Dominiczak. Med. 8. 2eme edition.PRACTICAL LESSONS SYLLABUS 1. ClujNapoca. Corina Ionescu. Universitară "Iuliu Haţieganu". Enzime. 4. 1996. 36 . Teste biochimie. Universitară "Iuliu Haţieganu". Second edition. sciences. 10. 2000. Gh. Cluj Napoca. Srima. Quantitative evaluation of inhibition. value and limitations. Ed. Drug enzymatic induction. "Iuliu Haţieganu". Cluj-Napoca. Cluj-Napoca. cofactori enzimatici. Biochemistry. 2008. 11. Vitamine şi coenzime. 2. Risoprint. ClujNapoca. Gheorghe Jebeleanu. Luminiţa Diaconescu. Oxford. Roxana Lucaciu. Coupled systems in analytical biochemistry. 13. Gheorghe Jebeleanu. Baznes. Methods for protein purification. GL. 9. 6h 3. Parson. applications in clinical laboratory. Roxana Lucaciu. 2001. 14. Didactică şi Pedagogică S. Ileana Olteanu. Ed. Universitară "Iuliu Haţieganu". Corina Ionescu. DeBoeck. Aminoacids and proteins as buffer systems. Univ. Ed. 2001. Elsevier. An Imprint of Addison Weslez Longman. Cristina Drugan.. Med. 2008. Cluj-Napoca. 2002. Ed. Med. Ed. Enzymatic diagnostic. 3. Med. 4.. Medecine. Andreea Arsene et all. Biochimie metabolică. 1999. van Holde. Ahren. 1994. Isoenzymes. Cornelia Ţărmure. England. 3h 7. chromatography of affinity. Ed. 2. Methods for identification and quantitative determination of vitamins. Factors 3h affecting laboratory results. 9h Possibilities to express the enzymatic activity. Biochimie metabolică. Denisa Margina. W. Biochimie: Vitaminele în procesele metabolice. Jebeleanu. Ed. Enzymes. Med. Factors that affect the rate of enzymatic reactions. pharmacie. Cluj-Napoca. Preparation of biological material in the view of biochemical analysis. Med. Marek H. Ed. Ed.A. Ion6h exchange chromatography. Niculina Mitrea. 2002. Mathews. SURFACE CHEMISTRY AND COLLOIDS Dispersed Systems. Electrokinetic Phenomena. Brownian Motion Diffusion. DLVO Theory. 2. Sedimentation. Electronic Spectra of Molecules. Molecular orbitals theory. The Vibrations of Diatomic Molecules. Electron Spin Resonance Spectroscopy. Solubilization. SPECTROSCOPY Emission and Absorption Spectra. Vibration-Rotation Spectra. Lyophilic. The hydrogen molecule. Electrokinetic Effects. Biophysics and General chemistry TEACHING METHODS Lectures with PowerPoint presentations Practicals EVALUATION METHODS Written. Electric Properties of Colloids. Photoelectron Spectroscopy. Polyatomic molecules. Kinetic Properties of Colloids. Sedimentation. The Schrödinger Equation. Measurement of the diffusion coefficient. Classification of Dispersed Systems. The Particle in a Box. Chemical symmetry. Atomic Spectra. Translational Motion. 7. Electron Microscope. Photoacustic Spectroscopy. Electroosmose and electrophoresis. Viscosity. The Faraday-Tyndall Effect. Crystal Lattices. Fluorescence and Phosphorescence. Angular Momentum and Magnetic Moment. Vibration Motion. Raman Spectra. The Electric Double Layer. Osmotic Pressure. The measurement of the viscosity. TRANSPORT PROPERTIES Viscosity. Optical Properties of Colloids. Diffusion and Fick’s Laws.CHAIR OF PHYSICAL CHEMISTRY COURSE TITLE – Physical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES Students should acquire and be able to apply the principles and methods of physical chemistry in different pharmaceutical disciplines. Rotational Motion. Classification of Colloidal Systems. PREREQUISITE – Knowledge of Physics. The Solid State. Stability of Colloid Systems. Spin Quantum Number. X-Ray Crystallography. Experimental Methods. Applications. QUANTUM THEORY AND ATOMIC STRUCTURE The Wave Character of Particles and wave-particle dualism. Reology. Nuclear Magnetic Resonance Spectroscopy. Optical Rotatory Dispersion (ORD) and Circular Dichroism (CD). Light Scattering. CHEMICAL BOND The valence bond theory. 8. Lyophobic and Association Colloids. Solid-Liquid Interfaces. The Structure and Spectra of Hydrogen Atoms. Homonuclear diatomic molecules. 3. Theories and Models of Solids. Laser Spectroscopy. The Vibrations of Polyatomic Molecules. Donnan Membrane Equilibrium. oral and practical exam at the end of each semester TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 28 hours (28/0) PHYSICAL CHEMISTRY COURSE SYLLABUS 1. Pure Rotational Spectra of Molecules. 37 4h 2h 8h 4h 10 h . Spectroscopic titration of I2 with Na2S2O3 2h 12. Interfacial Properties of Suspended Particles. Iuliu Marian. Karaman. Molecular Sizes and Shapes. Application of Lambert-Beer’s law to determination of a binary mixture 2h 11. Adsorption Isotherms. Chimie Fizică. London. Pharmaceutical Press. Physical Stability of Suspensions. Oxford University Press. Polymers and their pharmaceutical applications. Editura Casa Cărţii de Ştiinţă. Cluj Napoca. Critical micellar concentration 2h 7. Qualitative aspects of IR spectroscopy 2h 13. Richard M. Microemulsions. Surface Tensions and Capillarity. Micrometrics. 2004 4. Chimie Fizică experimentală. The Microstructure and Shapes of Polymer Chains. Applied Colloid and Surface Chemistry. PRACTICAL LESSONS SYLLABUS 1. Acetic acid adsorption on active carbon 2h 8. 1983 5. Suspensions. Editura Medicală Universitară “Iuliu Haţieganu”. General aspects of spectroscopic methods 2h * 9. Dan Rusu. Cluj Napoca. Emil Făgărăşan. Physical Pharmacy-Physical Chemical Principles in the Pharmaceutical sciences. Optical activity measurements 2h 14. Editura Mirton. David Attwood. Alexander T. Martin. The isoelectrical point of 2h proteins 6. Pashley. Settling in Suspensions. Methods for Determining Particle Size. Physical Stability of Emulsions. The hydrolysis of aspirin. Physical Chemistry. Peter Atkins. Curs de Chimie Fizică şi Coloidală pentru farmacişti. Ludovic Kurunczi. Deviations from Lambert-Beer’s law. Viscosity determination of dextran 2h 5. The solvent effect on n-π transition in CO 2 h group 10. Methods for Determining Surface Area. John Wiley & Sons. Emulsions. 2005 7. Kinetic study of tetracycline degradation in acidic medium 2h 3.. 2000 6. 2004 3. Marilyn E. Philadelphia. Recognition of emulsions type and their inversion. Practical exam 2h References 1. Swarbrick. 2002 2. A. Silvia Imre. Julio de Paula.Elemente de termodinamică şi structură. A. Determination of Rheologic Properties. Stability profile as a function of pH 2h 4. Florence. The Sizes of Macromolecules. Superficial tension and pharachorus. Physical Properties of Solid Polymers. 2007 38 . Physicochemical Principles of Pharmacy. Cammarata. Timişoara. Kinetic study of sacharosis hydrolysis in acidic medium 2h 2. Adsorption.Thermodynamics of Solubilization. Adsorption isotherms. Lea & Febiger. Ltd. J. 3. Fibrinolysis 5. Haemostasis. The EKG interpretation 4. Organization of the human body. The cardiovascular system. Levels of organization The cell: structure. physiological haemostasis-bleeding time. erythrocyte sedimentation rate test. Organization of human body. The respiratory system 8. determination of biliary secretion. haematopoiesis. 2. tissues. The digestive system. General presentation of internal organs. The cardiovascular system. platelets. red blood cells.CHAIR OF PHARMACOLOGY. 39 0. PHYSIOLOGY AND PHYSIOPATHOLOGY COURSE TITLE – Anatomy and general physiology COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire basic knowledge of anatomy and physiology essential for the study of speciality disciplines. 2. The digestive system 7. Functional explorations 7. roles.5 h 3h 1h 7. Functional explorations: red blood cells counting. 6. The blood. blood groups. Laboratory animal dissection. factors influencing biliary secretion 5. leucocytes. PREREQUISITE – high school level anatomy and physiology knowledge TEACHING METHODS Lectures and interactive discussions Practicals EVALUATION METHODS Written and practical exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 28 hours (28/0) ANATOMY AND GENERAL PHYSIOLOGY COURSE SYLLABUS 1. Functional explorations. immunity. creatinine clearance 6. The central nervous system: structure and functions 10. haemoglobin identification. determination of blood groups in ABO and Rh system. general and special properties The tissues The blood: composition. organ. The endocrine system: the suprarenal gland-structure and functions PRACTICAL LESSONS SYLLABUS 1. Functional explorations: the urine examination. glucagon and epinephrine on glycemia. system. 4. The sensory organs 11. main organ systems. Determination of normal glycemia. The endocrine system. The renal system. PCV determination.5 h 4h 3h 2h 1h 2h 2h 2h 2h 8h 4h 2h 2h 2h 2h . Functional explorations: enzymatic activity. coagulation time 3. Functional explorations: determination of blood pressure. The influence of insulin. such as structural and functional aspects regarding cells. The respiratory system. The autonomic nervous system: structure and functions 9. Coagulation. Cârmaciu R. Ed. Sălăvăstru C. Corint. De Boeck Université.. Ed. Niculescu C..Hypoglycemic coma in laboratory animals 8. Ed. 2... 5.. deuxieme edition. Herve Guenard et colab. 1999. 1997. Alternative methods for physiology study: computer programs 2h References 1. Fiziologie umană. 2003 7. Ed. 1999. Ciornei C.. Structura şi funcţiile organismului uman. et colab. Ader J-L. Ed. 2001. The nervous system: structure. Influence of 2 h adrenaline and acetylcholine on the heart functions 10. Pradel. Ed.. Medicală Universitară «Iuliu Haţieganu » Cluj-Napoca. 4. Physiologie. Physiologie. Niţă C. Physiologie humaine. Haulică I. Tache S. Anatomia şi fiziologia omului...F. Sherwood L. Masson. Bucureşti.. 40 . DeBoeck Universite 2000 6. Bucureşti... Ed. Physiology humaine. 3. The sensory organs 2h 9. Schmidt R. Medicală. Voiculescu B. Autonomic nervous system. 1996. . 3. 87-94. Ed. 5. Wells B. DeBoeck Université. Medicală Universitară « Iuliu Haţieganu » ClujNapoca. PHYSIOLOGY AND PHYSIOPAHTOLOGY COURSE TITLE – Physiopathology COURSE OBJECTIVES Acquiring fundamental concepts of physiopathology: fundamental defence mechanisms. physiopathology of disease.. Yee G. Fiziopatologie. Appleton&Lange 1999. 1998.. Frison-Roche-Slatkine. obstructive pulmonary diseases 1h 4. Curtis M.. 1999. Fundamental defence mechanisms: inflammation.C.G. 41 . lipid metabolism. Ed. Sutter M. Schorderet M. ischemic heart diseases 1h 3...M.L. 4.J. phosphor 4 h and calcium metabolism. Pharmacologie intégrée. thermoregulation. arterial hypertension. Ed..S.. Patofiziologie. Bucureşti 1999.. Dipiro J.J. The physiopathology of carbohydrate metabolism.B. Page C.. 69-81. A Pathophysiologic Approach. Ed.R. pain.. Walker M. Posey L. Pharmacologie. Matzke G.. iron metabolism References 1. Ed. 4 h haemostasis 2. Cardiovascular physiopathology: heart failure. physiopathology of electrolyte and metabolic disorders PREREQUISITE – anatomy and physiology knowledge TEACHING METHODS Lectures and interactive discussions EVALUATION METHODS Written exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (0/14) PHYSIOPATHOLOGY COURSE SYLLABUS 1. Hoffman B. Cerma. Des concepts fondamentaux aux applications thérapeutiques.T. Pleşca-Manea L. Digestive physiopathology: Disorders of digestive secretions and motility 5. 1992.CHAIR OF PHARMACOLOGY. Respiratory physiopathology: bronchial asthma..C. Paris. cardiac 4 h arrhythmias. 2. Talbert R. Aramă Ş..P. Pharmacotherapy. soil. Doina Matinca. Microscopy practical individual studies for isolation and identification of bacterial species. Microbiologie. Parasitology 1h 10. of 80% TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 42 hours (0/42) Practical lessons– 28 hours (0/28) MICROBIOLOGY. Bacterial genetics 6h 5. air. mycology. virology. Ed. Infection and anti-infectious defence 4h 8. Cluj Napoca. Cahier de traveaux pratiques à l’usage des étudiants en Pharmacie. 42 . VIROLOGY. Hodarnau –Lucrari practice de microbiologie pentru studentii Facultatii de Farmacie. based on their properties in culture 2. antibacterial testing EVALUATION METHODS Written and practical examination Practical examination (theoretical knowledge and the practical abilities evaluation): the percentage from the final mark: 20% Theoretical examination (mcq): the percentage from the final mark. the knowledge of drug contamination. Bacterial morphology 6h 3. Cristian Hodârnău. PREREQUISITE – genetics. Virology 6h 9. biochemistry TEACHING METHODS Course: Lectures with visual presentations Practical works: Interactive programmed education. virology. Microbiology of drugs 2h PRACTICAL LESSONS SYLLABUS 1. hospital environment.Universitară „Iuliu Haţieganu”. Luciana Stănilă – “Bacteriologie generale et virologie – a l’usage des etudiants en medicine. Cluj-Napoca 5. «Iuliu Haţieganu » 2006. Chemotherapy 6h 7. 2002 4. Disinfectants and antiseptics 2h 6. medicine dentaire et pharmacie”. Cecilia Boboş. the knowledge of the main human pathogen genres and species. parasitology COURSE AND PRACTICAL LESSONS OBJECTIVES acquiring fundamental knowledge: bacteriology. 2003 3. Laboratory diagnostic in infections produced by the main pathogens for humans 16 h References 1. Med. Luciana Stanila – Cahier de travaux pratiques a l’usage des etudiants en Medicine et Pharmacie. Bacterial physiology 6h 4. Univ. biology. Doina Matinca. Mycology. Isolation and identification of pathogenic bacteria and microorganisms from the 12 h environment (water. Ed. General bacteriology 3h 2. 1995 2.CHAIR OF MICROBIOLOGY COURSE TITLE – Microbiology. medical instruments). parasitology. C. Doina Matinca – Microbiologie pentru studentii Facultatii de Farmacie. Med. PARASITOLOGY COURSE SYLLABUS 1. Cell cycle. Simple diffusion. cytophysical methods. The effect of colchicine on mitosis. endocytosis. electron microscopy. Cell centre and functions of microtubules. Molecular organization of DNA. Cell membranes: classification. DNA synthesis (replication) 6. Molecular organization of biological membranes. Exocytosis. The analysis of active principles obtained from cell cultures 4. Cytochemical localisation of nuclear acids 5. Histological technique and microscopy slide preparation 2. Phytobiological test for cytostatic substances 6. Masson Paris. Electron microscopy techniques and interpretation of EM images References 1. Erythrocyte membrane. cytochemical. Antimitotic agents. 2.CHAIR OF PHARMACEUTICAL BOTANY COURSE TITLE – Cell and molecular biology COURSE AND PRACTICAL LESSONS OBJECTIVES Accumulating knowledge regarding vegetal and animal cell organization and functions. 5. Biological role of the nucleus. The importance of cell and molecular biology for the pharmaceutical training. In vitro cell and tissue culture techniques applied to medicinal plants 3. Transport through membranes. Cytostatic agents. synthesis of proteins (translation).: Biologie cellulaire. Recent developments in cell and molecular biology. cell constituents and their biological role PREREQUISITE – general biology at high school level TEACHING METHODS Course: Lectures with power point presentation Laboratory: Experimental demonstrations and individual practice EVALUATION METHODS Evaluation of practical abilities and capacity of interpreting experimental data (20% from final score) Standard or MCQ (multiple choice questions) written exam (80% from final score) TEACHING LANGUAGE Romanian language French language English language NUMBER FO HOURS Course – 28 hours (28/0) Practical lessons – 14 hours (14/0) CELL AND MOLECULAR BIOLOGY COURSE SYLLABUS 1. RNA synthesis (transcription). Uniport. 2000 4h 6h 4h 4h 8h 2h 4h 2h 2h 2h 2h 2h 43 . antibiotics inhibition. Carrier and channel proteins. antiport systems. Active and passive transport. Maillet M. Cell study techniques: histological techniques. biological and pharmaceutical role. symport. cell study methods. Cell junctions. Tumoral cell biology PRACTICAL LESSONS SYLLABUS 1. transcytosis. 4. Lectins and liposomes 3. DNA structure.applications in pharmaceutical industry 1h 12. DNA Cloning 1h 10.. Masson. Molecular biology . Ed. Masson. 6e édition.CHAIR OF PHARMACEUTICAL BOTANY COURSE TITLE – Pharmacogenetics COURSE AND PRACTICAL LESSONS OBJECTIVES Accumulating knowledge regarding the molecular basis and techniques used in Technology of ADN-recombinant and their applications in pharmaceutical industry. Gene 1h 2. Polymerase chain reaction (PCR) 2h 5. Restriction enzymes 1h 11. Coman N. Cluj-Napoca. 2000.. The agarose gel electrophoresis of DNA 2h 4. Genetică generală şi moleculară abordare practică – Ed. Dordea M. Genetique. Biochimie génétique Biologie moléculaire. virtual laboratory EVALUATION METHODS Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical activities and written test) at the end of semester (20% from final score) Multiple choice questions (MCQ) test at the end of semester (80% from final score) TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (0/14) Practical lessons – 14 hours (0/14) PHARMACOGENETICS COURSE SYLLABUS 1. PREREQUISITE – General genetics (high school level). genetic code 2h 2. PCR – technique 1h 7. 1996 3. 234-259. Genetic code. 4. Biotehnologii celulare. 2000 2. Transgenic plants 1h 13. Presa Universitară Clujană. Paris. Cătană C. Étienne. J. 1h 9.DNA chip (gene chip) 2h 6.techniques of analyses 1h 8. DNA sequencing. Milan. DNA replication 1h 5. Notion of Genomics. Cluj-Napoca. cell biology knowledge TEACHING METHODS Course: Lecture with power point presentations (multimedia type) Laboratory: Individual practice. Vectors of cloning 1h 6. Gene therapy 2h PRACTICAL LESSONS SYLLABUS 1.-L. Paris. Genetic therapy 2h References 1. 4e édition . Risoprint. 44 .. Nucleic acids: chemical structure and biological role of DNA 1h 3.. 2005. The genetic transformation of plants 2h 7. 78 p. Technology of DNA-recombinant. The extraction and isolation of DNA 2h 3. Nucleic acids: chemical structure and biological role of ARN 1h 4. Rossignol. Genetic disorders. Crăciunaş C.. J. Nucleic acids. Barcelone. Andraş C. Tipografia UMF: Cluj-Napoca.ac.html 45 . Becton-Dickinson. Devices for sexual protection and birth control. Ed. mode of use and maintenance). 5. 10. labelling.uk/teaching/undergrad/projects/2003/group_03/index. Definitions. TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (0/28) MEDICAL DEVICES COURSE SYLLABUS 1. Materio. Medical devices for in vitro diagnostic (Self-testing devices). 4. Needles for syringes. future pharmacist must know the technical aspects related to medical products and devices (raw materials: description. Simona Mirel. 8. elaboration and presentation of reports an a given topic. 1992 6. 6.ucl. Medical gloves. 3. Devices used for 4 h determining the temperature. 1996. Devices used for the determination of biochemical parameters. marking in EU) and medical recommendations. TEACHING METHODS Interactive lectures with PowerPoint presentations. 5. Devices used for parenteral drug administration. Raw materials used for obtaining medical devices and products. Sterilisation of medical devices and products. Skin injuries. conservation. Surgical 3 h fields. 3 h Dressing’s classification. Arnette Blackwell:Paris. 2008 2. Roşca M. chemistry. Medical devices used in surgery.Knowledge of physics. 2. Produse Tehnico-Medicale. GALTIER F.CHAIR OF MEDICAL DEVICES COURSE TITLE – Medical devices COURSE OBJECTIVES As a health professional. Blood pressure monitoring. La stérilisation. Devices for surgical incision. Biomaterials. regulatory issues (classification. Checking sterility. Devices for 2 h surgical suture. Classification. discussions and explanations Individual study and documentation EVALUATION METHODS Written exam. Dressing materials. Introduction. Protection materials and equipments. PREREQUISITE . Contraception through the 2 h barrier methods. Les biomatériaux du futur. 3. Materials for dressing’s fixation. Syringes. Importance of medical devices and products for pharmaceutical care: Legislation 4 h of medical devices. 2 h Biocompatibility. Flavius Neag Produse tehnico-medicale. Wound healing. anatomy. Disponibil la: URL: http://www. Neo-natal care products 2h References 1. Ed. 4 h Instruments and apparatus for venous drug administration. [online]  [citat 2007 iun 20]. Roşca M. Sterilization processes. 1996. (ISBN 978-973-693-278-6). The intrauterine device. Surgery masks. Tipografia UMF: Cluj-Napoca. 9. The concept and principles of 2 h medical devices and products sterilization. 2001 4. XXX. Devices used to determine blood pressure.vigilance. Produse Tehnico-Medicale. Editura Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. 7. Types of dressings.medphys. Dressing’s characteristics. The main radicals for human body. Terms used to describe the relation physician-patient-pharmacist. knowledge of analytical chemistry. by learning prefixes and suffixes commonly used and their combinations with basic radicals. The parts of a word. The radicals. the correct correlation between specific terms and their significance or their medical and pharmaceutical purpose. plastic and rubber objects used in the laboratory. 6.CHAIR OF TOXICOLOGY COURSE TITLE – Pharmaceutical terminology COURSE AND SEMINARY OBJECTIVES To acquire knowledge and to practice specific medical terms by activities such as: the correct analysis of components of medical and pharmaceutical terms. Terms used for locomotor system 6. 4. 3. Medical and pharmaceutical specialities. The description of human body in Romanian language. organic chemistry TEACHING METHODS Interactive lectures and seminaries EVALUATION METHODS Written exam TEACHING LANGUAGE English language NUMBER OF HOURS Course – 56 hours(28/28) Seminary – 28 hours (14/14) PHARMACEUTICAL TERMINOLOGY COURSE SYLLABUS Istr SEMESTER – MEDICAL TERMINOLOGY 1. metal/alloy objects. Revision IInd SEMESTER – PHARMACEUTICAL TERMINOLOGY 1. extraction and purification of pharmaceutical substances. Installations used for the synthesis. 2. 12. inorganic chemistry. Terms used in gastro-enterology 8. Introduction in pharmaceutical terminology. 46 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h . 3. Terms used for cells and tissues. Terms used in endocrinology. Terms used in neurology and psychiatry. Terms used in andrology and obstetrics-gynaecology. 11. physical chemistry. 4. The general organisation of human body. Terms used in pneumology 7. 5. Romanian terms used to designate the main glass objects used in the laboratory. The hemato-lympoid system. physiology from high school. Terms used in haematology and immunology. 10. PREREQUISITE – knowledge of anatomy. 14. Terms regarding the organisation of a pharmacy and the pharmaceutical profession. The periodical table of elements. 13. prefixes and suffixes frequently used to form pharmaceutical terms. Terms used in nephrology and urology. Romanian terms used to designate the main porcelain objects. To learn the speciality terms in Romanian language and their use. Terms used in cardiology and angiology 9. by the knowledge of the rules in the formation of specific terms. 5. Rules for formation of names of chemical substances in Romanian language. 2. D. Méthode et activités. 11. Terms used in pharmaceutical technology.7. Learning pharmaceutical terms specific for certain pharmaceutical specialities by exercises: word construction. The identification of a word’s significance due to the operating unit. 10 h 3. identification of specific terms in scientific papers and explanation of their meaning. B. classification of words with the aid of operating unit. Editions Casteilla. Terms used in drug analysis. 2h 9. Lăcrămioara Ochiuz. The unities of meaning. Lacroix – Terminologie médicale. 12. Terms used in biotechnology and in industrial synthesis of drug substances. classification of words with the aid of operating unit. 2h 13. Terms used for the raw 2 h materials of pharmaceutical use. Terms and abbreviations used 2 h to define the main administration routes of drugs. Learning the main radicals for human body by exercises: word construction. Terms used in biopharmacy and pharmacokinetics. The 5 senses. 8. Terms used in modern criteria of drug classification. Abbreviations and symbols 2 h used to name the drugs. 2007 2. Editions Lamarre. Lupuleasa – Terminologie medicală şi farmaceutică. 2002 3. Bibliographie 1. 12 h 2. The construction of a word based on specifically 2h defined radicals. crossing words. classification of words with the aid of operating unit. Learning medical and pharmaceutical terms specific for certain medical and pharmaceutical disciplines by exercises : word construction. identification of specific terms in scientific papers and explanation of their meaning. Revision 2h SEMINARY SYLLABUS Itr SEMESTER – MEDICAL TERMINOLOGY 1. The construction of specific words for pharmacy based on defined radicals. exercises of correspondence between the terms and their significance. 2h 14. Editura Polirom. Cahier d’exercices. identification of specific terms in scientific papers and explanation of their meaning. 2h 2. 2000 47 . Thieulle – Pratiques du mot médical. Bucureşti. nd II SEMESTER – PHARMACEUTICAL TERMINOLOGY 2h 1. Terms used in industrial pharmaceutical technology. The identification of a word significance based on the operating unit. J. Terms and abbreviations used to write a prescription. RueilMalmaison. Paris. Iuliana Popovici. 2h 10. types of drugs. Essays on controversial topics (addiction. course books.The development of the other three basic language skills: reading (active and intensive reading of specialized texts. popular science and non-specialist articles). The main objective is the development of specific communication skills. Filling in tables and diagrams in specialized texts 2. alternative medicine). paper and poster presentations). self-medication. Articles of scientific papers: structure. Specific objectives include: . the practical course also contributes to the development of the students’ teamwork skills. case presentations 3. speaking) EVALUATION METHODS Written and oral examination (representing 25%+25%=50% of the final mark). formal letters (representing 50% of the final mark) TEACHING LANGUAGE English/ Romanian NUMBER OF HOURS Practical seminaries – 42 hours (28/28) ROMANIAN LANGUAGE COURSE SYLLABUS Reading skills 1.none TEACHING METHODS The communicative method Integration of the four basic language skills (writing. through employing lexical. dieting. summarizing scientific articles 48 2h 2h 2h 4h 2h 2h 2h 4h . Abstracts of scientific papers: structure. PREREQUISITE . verb tenses. Prescriptions. Drug information leaflets.CHAIR OF MODERN AND APPLIED LANGUAGES COURSE TITLE – A Practical Course in Romanian (for foreign students) for Pharmacy COURSE OBJECTIVES The practical course is aimed at ensuring the acquisition of modern language knowledge and skills that students may use both in a general as well as in a specialised context related to their future profession. reconstructing articles according to text structure 4. connectors. case presentations. Case presentations (illnesses. . essay. oral communication (situational communication. reading. developing reading speed). Curriculum Vitae. Tables and diagrams in specialized texts. interpreting information 2. agreeing and disagreeing. morphological and discourse analysis elements as well as through the identification of text structure and conventional format. Abstracts of scientific papers: conventional format. summaries. listening. Drug formula. Identifying the structure of various specialized texts. including portfolio. class activity. medication) 3. and listening (understanding and making use of the information in a spoken text). expressing personal opinions 4. conversation on professional topics.The development of writing skills through the analysis of text rhetoric (scientific research articles. Through pair work or group work activities. reconstructing paragraphs from separate sentences using connectors Writing skills 1. Manual pentru studentii straini. Iasi. 2003 4. Listening for detailed information in a specialized course or lecture 2h (e. agreeing and disagreeing. 1996 3. Saramandu Mariana. Ed..g.. Debates on controversial topics (addiction. Ionescu Adriana.Listening skills 1. vitamins. Bilunar de informaţie pentru lumea medicală». 49 . A. Limba Romana. 4h expressing personal opinions 2. Basic pharmaceutical pronunciation 2h 4. Ed. Ed. editia a IV-a. Universitatii din Bucuresti. substance abuse) 2. Fotea. Ed. Liana. editia a III-a. 2001 2. « Hipocrate. Cluj. 4h evaluating. 1999 5. Listening to a specialized text for taking notes or transferring information 2h 3. Echinox. Gramatica limbii romane. Reviste de specialitate: « Farmacia ta ». G. Dorobat.. explaining data Final examination 4h References 1. comparing. Cluj.. Romana cu sau fara profesor. Pop. Limba romana de baza. Bejan. dieting. self-medication. Oral presentation skills: preparing for the final project (poster or PowerPoint presentation) – describing. « Gazeta Farmaciştilor. alternative medicine). Mechanisms of drug action. D. Watching films on scientific topics – specific listening tasks 4h Speaking skills 1. Institutul European. Brancus. Revista colegiului farmaciştilor din România ». «Lumea farmaceutică ». M. Echinox. editia a V-a. badminton. Initiation in the practice of a game: basket. Massage and self-massage gestures. football. Aerobics. suppleness. as a component of a healthy life-style. Perform specific activities necessary for a systematic individual practice of physical activities. 50 . To prevent and correct deficient attitudes and to recover after traumatic sequels following certain illnesses.CHAIR OF SPORT COURSE TITLE – Sport COURSE OBJECTIVES To maintain an optimum physical condition. Theoretical and practical elements for physical self-education. Fitness. volley-ball. table tennis. resistance. To correctly form a development system and motrice principles (basic and used in certain sport disciplines). To develop qualities and voluntary and moral characteristics and to stimulate the esthetical sense and social responsibilities. Exercises for the prevention of deficient attitudes or organic deficiencies due to the specificity of professional activity. speed. PREREQUISITE TEACHING METHODS Physical exercises EVALUATION METHODS Practical examination TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Practicals: 56 hours (28/28) SPORT Perform several practical activities necessary for the consolidation of technical and tactical precepts specific for individual and collective sports. Exercises for the development of motrice qualities: force detente. tennis. To develop basic motrice qualities as well as specific qualities necessary for different sports. To develop the skills needed to acquire a systematic practice of physical exercises. Diversify physical education and sport activities according to students’ choice and to individual biometric configuration (individual physical condition). Jogging. Exercises for learning technical gymnastic and athletisme elements. coordination skills. Perform practical activities necessary for the development of basic motrice qualities. To contribute to growing process and to favour a normal physical development. 4.CHAIR OF MEDICAL DEVICES COURSE TITLE – Summer practice for the 2nd year students in pharmacy OBJECTIVES OF THE PRACTICE acquiring knowledge on main activities of the practice of pharmaceutical profession acsuiring knowledge on the properties of pharmaceutical substances PREREQUISITE . 2008 3. * 30 hours/week – 2 weeks References 1. the destination of each room. Nomenclatorul de medicamente şi produse medicamentoase de uz uman. Memomed. 2008 4. Performing analysis for the identification of drug substances. analysis on how to solve professional problems EVALUATION METHODS Characterization of student’s work by the tutoring pharmacist regarding: 1. Editura Medicală. physical chemistry TEACHING METHODS The application of theoretical knowledge acquired during the first year in pharmacy practice. Editura Medicală. Farmacopeea română. Designation of the workplace: location. Agenda medicală. Bucureşti. Knowing Romanian Pharmacopoeia X-edition. schematic plan. organic chemistry. X. Bucureşti.2 weeks (0/60) SUMMER PRACTICE FOR THE 2ND YEAR STUDENTS IN PHARMACY PRACTICE SYLLABUS 1. 3. 1993 2. monitoring and verification of a pharmacist as tutor Explanations. under the coordination. therapeutic uses. 2008 51 . Performing division of some pharmaceutical specialties. Editura Minesan. Agenţia Naţională a Medicamentului. The attitude towards the staff in the pharmacy Filling the practice notebook Oral exam TEACHING LANGUAGE Romanian language French and English language for foreign students that perform the practice in their own country NUMNER OF HOURS 30 hours / week . analytical chemistry. Knowledge of drug substances: physical and chemical properties.IPhTL. Frequency 2. discussions. 5. Ed. Involvement in the pharmacy activity 4. Compliance with internal regulation 3. Bucureşti. Bucureşti. 2. essential biological properties. their chemical. General chemotherapeutics Nitro furans Halogenated 8-Hidroxychinolines Quinolones 52 14 h 9h . chemical structure-biological activity relationships. disinfectants. elaboration of presentations on a specific subject EVALUATION METHODS Written exam Exam form the laboratory activity Tests during the semesters Independent work The laboratory activity and the tests during the semesters represent 25% of the final score. antiinfectious chemotherapeutics and antitumoral medication regarding: physico-chemical properties. Microbiology. PREREQUISITE .knowledge of: Inorganic chemistry. spectral identification and the control of their purity.CHAIR OF PHARMACEUTICAL CHEMISTRY COURSE TITLE – Pharmaceutical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES Objectives of the course – acquiring knowledge on the antiseptics. Informatics TEACHING METHODS Lectures with PowerPoint presentations and video-projections. Analytical chemistry. synthesis. chromatographic. Physical chemistry. pharmaceutical presentation. nomenclature of compounds. optimization of the biopharmaceutical and pharmacokinetic properties Objectives of the practical lessons – acquiring knowledge on the physico-chemical properties of the antiinfectious medical substances. Organic chemistry. seminars on up-to-date problems. Antiseptics and disinfectants Halogens and halogenated compounds Oxidants Compounds of the hard metals Compounds of the aluminium and tin Bore compounds Alcohols Phenols and phenol derivatives Carbonylic compounds and their derivatives Guanidine derivatives Detergents Colorants 2. TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 70 hours (28/42) Practical lessons – 84 hours (42/42) PHARMACEUTICAL CHEMISTRY COURSE SYLLABUS 1st SEMESTER 1. Chemical identification of the organic drugs 18 h 3. Exam 3h 2nd SEMESTER 1. Phenols 3. Chemical identification of the inorganic drugs 12 h 3. Presentation of FRX. Chemical identification of antibacterial antibiotics 12 h Betalactamines Macrolides Aminoglicosides Phenicols Tetracyclines 2.Sulphamides 3. Presentation of the 3 h laboratory.1. Halogenated derivatives 3. cumarines 2. UV) identification of some antibiotics 6h 53 . Spectral (IR.3. Sulfamides 4. Limited specificity chemotherapeutics 16 h Antituberculosis Antileprose Antimicotics Antiviral 3. Alcohols 3. 2. Antibacterial antibiotics 20 h Betalactamines Phosphonates Lincosamides Macrolides Rifamicines Polypeptides Glycopeptides Aminoglicosides Tetracyclines Phenicols Streptogramines Oxazolidinones Diverse: fusidanines. Purity control of the drugs based on FRX requirements 15 h 3.4. Presentations based on scientific articles 6h 5. Security and personal safety in the laboratory. Antineoplasic medication 6h Antineoplasic chemotherapy Cancer hormonotherapy Immunotherapy in cancer New approaches in the therapy of cancer PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. Antiparasitary medication 5h Antimalarics Antitrichomonasics Antiamibienes and antilambliasics Antihelmintics 2nd SEMESTER 1.2. BRINDUSA TIPERCIUC. 1992 6. BRINDUŞA TIPERCIUC . Ed. LAURA COSTEA. O. 17-eme edition. Tec and Doc. Medicales Internationales TEC and DOC. 2003 9. Editura Medicală Iuliu Haţieganu Cluj-Napoca. 2004 11. Ed. E.Iuliu Haţieganu.. ONIGA. DOINA GHIRAN. A molecular and Biochemical Approach. OVIDIU ONIGA. Medicaments antibiotiques (vol 2). tome 2). Exam 3h References 1. Identificarea substanţelor medicamentoase prin metode chimice. 2000 8. dezinfectante şi chimioterapice generale. Elsevier Academic Press. OVIDIU ONIGA. DOINA GHIRAN.Chimie Farmaceutică Antiseptice. Medicinal Chemistry. AFECT -Traite de Chimie Therapeutique. Medicales Internationales TEC and DOC. Litografia UMF Iuliu Haţieganu Cluj-Napoca. WEAVER. Medicaments antitumoraux et perspectives dans le traitement des cancers. UMF . 2005 12. The organic Chemistry of Drug Design and Drug Action.6. antivirale. O. AFECT. OVIDIU ONIGA. Editura Accent Cluj-Napoca. vol.Antibiotice antibacteriene. AFECT . APPIT. second edition.4. Ed. Editura Medicală Iuliu Haţieganu ClujNapoca. WILSON and GISVOLD’S Textbook of Organic Medicinal and Pharmaceutical Chemistry. Presentations based on scientific articles 6h 5. 2005. ONIGA. SILVERMAN. eleven edition. RICHARD B. Lippincott Williams and Wilkins. 1999 2. 2004 5. DONALD F.. Principaux antifongiques et antiparasitaires (vol 5.Maladies infectieuses and tropicales. Scheme de curs. CRISTINA MOLDOVAN. 1995 7. 2001 3. Antimicobacteriene. 54 . 2004 10.Antibiotice antibacteriene şi chimioterapice cu specificitate limitată. 2003 4. antimicotice.Chimie Farmaceutică. BRINDUŞA TIPERCIUC .Traite de Chimie Therapeutique.Traite de Chimie Therapeutique. III-rd edition. ed. Ed. BRINDUŞA TIPERCIUC . THOMAS NOGRADY. Ed. Pilly. BRINDUSA TIPERCIUC.Medicaţia antiinfectioasă. Cluj Napoca. Ulmariae flos etc.) 4. Capsici fructus). tropane alkaloids (Belladonnae radix et folium. protoalkaloids (Colchici semen.CHAIR OF PHARMACOGNOSY AND PHYTOTHERAPY COURSE TITLE – Pharmacognosy and phytotherapy COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire knowledge regarding the main characteristics of vegetal raw materials used to obtain herbal drug preparations or other medicinal preparations in pharmacy or in industry. Fumariae herba. underlining their origin. natural raw materials are studied. General Pharmacognosy 3.terpenoid alkaloids (Aconiti tuber). The classification of natural products is based on the chemical structure of the main active compounds: sugars. aromatic compounds.quinoline alkaloids (Cinchonae cortex). Cacao oleum etc. resins etc. Boldo folium etc. Natural products containing aromatic compounds: . Natural products containing protids ( Visci folium) 6. Practical applications present the methods of qualitative and quantitative analysis of the active principles in medicinal plants. Nivalis bulbus) 2nd SEMESTER 1. reports.) . chemical composition as well as the therapeutical effect of the main active compounds. Secale cornutum.indole alkaloids (Physostigmatis semen.) .). Berberidis cortex.aromatic compounds type C6 (Vitis ideae folium. harvesting. Althaeae radix. Chelidonii herba. Natural products containing alkaloids: .C1 (Salicis cortex. Rauwolfiae radix etc.. Cocae folium etc. Theae folium etc. essential oils. Analytical chemistry TEACHING METHODS Course – Lectures with Power Point presentations Practical lessons . proteins. purine alkaloids (Coffeae semen.) . Natural products containing lipids (Helianthi oleum. Cacao semen.) 5. aromatic compounds 55 3h 6h 3h 3h 3h 5h 4h 5h 4h 6h 3h . compounds with isoprenic structure. After the presentation of general terms on this field. Tiliae flos etc.) . aromatic compounds type C6 .quinolisidine alkaloids (Cytisi semen. PREREQUISITE – knowledge of Botany. Hyoscyami folium. compounds with nitrogen having special structure (Taxus sp. Granati cortex etc. Natural products containing sugars and derivatives (Verbasci flos. seminaries. alkaloids. Organic chemistry. The aim of these studies is to consolidate the scientific base for medicinal plant use in phytotherapy.).).Power Point presentations. Introduction 2. practical applications EVALUATION METHODS Practical and written examination TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 84 hours (42/42) Practical lessons – 84 hours (42/42) PHARMACOGNOSY AND PHYTOTHERAPY COURSE SYLLABUS 1st SEMESTER 1.piperidine alkaloids (Lobeliae herba. isoquinoline alkaloids (Opium. Uvae ursi folium etc. Sarothamni herba). lipids. ). steroids: saponosides (Ginseng radix.atypical monoterpenoids (Valerianae rhizoma cum radicibus.aromatic compounds type C6 – C3 – O: coumarins (Fraxini folium. natural steroids. Resins.carotenoids (Tagetes flos. Frangulae cortex. Isolation and purification technologies.) 3 h . Analysis of natural products containing terpene compounds: . Ed. Adonidis herba etc. Ichtamolum etc.) . Thymi 9 h herba. Analysis of natural products containing alkaloids: .quinoline alkaloids 3h . Natural products containing terpenes compounds: .flavonoids 3h . Ginkgo folium. with sesquiterpenoids (Chamomillae flos.anthracenic derivatives 3h 2.aromatic compounds type (C6 – C3)n : lignans (Podophyli rhizome. Systematical Phytotherapy 6h PRACTICAL LESSONS SYLLABUS 1st SEMESTER l. Ratanhiae radix etc. with phenylpropan derivatives (Cinnamomi cortex.) 2h 2.anthracenic derivatives (Rhei rhizoma.isoquinoline alkaloids 6h . 2001 DANIELA HANGANU – Farmacognozie – Materii prime naturale cu compuşi aromatici. Millefolii flos). Analysis of natural products containing sugars 3h 3.).tannins 3h . Hippophae fructus etc. Hederae folium etc.) 4.) 2h 5. Analysis of natural products containing aromatic compounds: .) . Taraxaci herba etc. Silybi mariani 1 h fructus) . Calendulae flos. carotenoids 3h 3. Hamamelidis folium. cardiotonic glycosides (Digitalis folium.). Hippocastani semen. Carvi fructus.essential oils containing sesquiterpenoids 3h .purine alkaloids. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. Salviae folium etc. Meliloti herba 6 h etc.monoterpenoids 3h . phenylpropan derivatives.phenyl derivatives. Hyperici herba etc. Gentianae radix etc. Convalariae herba.Farmacognozie-Alcaloizi.With monoterpenoids (Lavandulae flos. Ed. flavonoides (Crataegi fructus. Anisi fructus etc. terpenoid alkaloids 3h 5. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. General pharmacognostical methods 12 h 2. tars (Balsamum peruvianum. Analysis of natural products containing essential oils: .cardiotonic glycosides. Primulae rhizoma.tropane alkaloids 3h .type C6 – C3 (Cynarae folium) .triterpenoids. tannins (Quercus cortex. Analysis of composed species 6h References: ILIOARA ONIGA . Analysis of natural products containing lipids 3h 4.indole alkaloids 3h . Foeniculi fructus. Saponariae 9 h radix.essential oils containing monoterpenoids 3h . Sophorae flos. Menthae folium. Analysis of composed species 6h 2nd SEMESTER 1. balms.) 1h 3.essential oils containing phenylpropan derivatives 3h 4.). 2005 56 . Natural products containing essential oils: . coumarins 9h .saponins 3h . Supergraph Tipo. Compuşi terpenici naturali. Fitoterapie. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. TĂMAŞ. Plante din culturi.Farmacognozie. Medicală. I II. Vol.1993 V.Farmacognozie. TĂMAŞ. Fitochimie şi Fitoterapie. E. Stănescu .Ghid pentru recunoaşterea şi recoltarea plantelor medicinale. Grigorescu. 2006 I. II. 1993 57 . Ed. Istudor . M. Plantes médicinales – Ed. vol.Analiza produselor naturale medicinale. U. 2005 ILIOARA ONIGA. DANIELA BENEDEC. I Flora spontană. Dacia Cluj Napoca. Fitochimie. Ed. Vol. Bucureşti. Bucureşti. FLORIAN . Cluj-Napoca. Ed. Tec et Doc – Lavoisier. S. Bruneton – Pharmacognosie. Ed. Ed.Ghid pentru recunoaşterea şi recoltarea plantelor medicinale. 2004 M. Editura Medicală Universitară "Iuliu Haţieganu" Cluj-Napoca. DANIELA BENEDEC. II2001 J. Ciulei.Plante medicinale. I-1998. vol. ILIOARA ONIGA. DANIELA BENEDEC.ILIOARA ONIGA . S. FLORIAN . 2007 ILIOARA ONIGA. DANIELA HANGANU . Medicală. Phytochimie. CHAIR OF PHARMACEUTICAL TECHNOLOGY COURSE TITLE – Pharmaceutical technology COURSE AND PRACTICAL LESSONS OBJECTIVES Acquiring knowledge regarding the formulation. physical chemistry. Additives for the preparation of solutions. Nasal drops. flavours. Drug dosage forms. Collutoria. Isotonicity. Relations with other sciences. local pathology. 7. Design. Quality. Rate of dissolution. mouth washes. Solubility. Suspensions and powders for injectable 58 2h 2h 2h 2h 2h 2h 2h 4h 2h . 9. Specific literature. additives. 5. Micellar solubilization. Labelling. Pharmaceutical technology. Increasing the solubility of drugs with poor solubility. Sweetening agents. Definition. PREREQUISITE – knowledge of chemistry. Solubility thermodynamics. antioxidants. Quality of drug dosage forms. containers. colours. Sterilization. local tolerance). Alcoholic and oily solutions. vehicles. Solutions. Obtaining the desired solubility. References. PH changes. Physical stability of pharmaceutical dosage forms. preparation and quality control of pharmaceutical dosage forms. Biopharmaceutical considerations. Good Manufacturing Practices. Pharmaceutical incompatibilities. Dissolution of drugs. Drugs. 6. temperature). Formulation. 3. Preparation. Preparation area. Quality control. physics. Purity (microbiological. Aromatic waters. Ear drops. Factors influencing solubility (pH. Examples of solutions for internal use. agents that increase viscosity. Lemonades. vehicles. drugs. 2. Preparation. systemic toxicity. Vehicles. industrial specialties.solvents. Biopharmaceutical considerations. Hydrotropism. 8. Packaging. Complexation. Injectable solutions. dose control. bioequivalence determination). Examples. Difficulties in the preparation of solutions. closures. Classifications. chemical and mechanical contamination). officinal and magistral solutions. washing solutions. Components. physico-chemical stability of drugs. biology TEACHING METHODS Lectures with PowerPoint presentations Practical applications EVALUATION METHODS Multiple choice exam Practical exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 56 hours (28/28) Practical lessons – 84 hours (42/42) PHARMACEUTICAL TECHNOLOGY COURSE SYLLABUS 1st SEMESTER 1. Relative indocility (dose. solubilizing agents. and antimicrobial preservatives. Gargles. Emulsions for injection. Quality of raw materials. Preparation of injectable solutions. Therapeutic efficiency (controlled clinical trials. Distribution in recipients and sealing. Filtration. additives. Factors influencing the rate of dissolution and their use in drug dosage form preparation 4. Syrups. Solutions for external use. Co. Melting and casting moulds. 9. Colloids. Conditioning. uses. Isotonicity. Quality control. Hydroalcoholic extractive solutions. Infusions with colloidal plasma expanders. 11. Pharmaceutical emulsions. Particle attraction.Quality control. Demulsification. Non-divided powders. Quality control. Tinctures. Classification. Factors influencing selective extraction and effectiveness of active principles extraction. Aqueous extractive solutions. Quality control. Recipients. soft. 12. Preparation of the pharmaceutical ointments. Quality control of ophthalmic solutions. Pastes. mixed dispersed systems. Powders for external administration. Powder mixing. Tear substitutes. Suppository preparation techniques. Preparation. Factors influencing extraction. Classification. Phase inversion. Stability of pharmaceutical emulsions. Preparation techniques. Drugs. Suspensions. Fluid heterogeneous pharmaceutical dispersions. Physical and chemical stability of ophthalmic solutions. Injectable solutions and infusions for ophthalmic use. 10. Wetting. Aqueous extractive solutions. Quality and quality control of infusions. infusions. Gels. Quality conditions and control. Examples. Excipients used for preparing ointment bases and their role. Biopharmaceutical considerations. Pharmaceutical ointments. 8. Mucilages. Preparation of the suspensions. Radiopharmaceuticals. Classification. Water soluble bases. Examples. 13. 2nd SEMESTER 1. Auxiliary substances used for preparing suspensions. Sterility. Classification. pH value. Vaginal suppositories. Compressed tablets. Macerations. Preparation of eye drops. Emulsions. Emulsifying bases. 7. Preparation. stability. HLB. Classification. Lyophobic colloids. Factors influencing the stability of suspensions. Raw materials. 5. Biopharmaceutical considerations. Flocculated and deflocculated suspensions. Quality conditions and control of suppositories. Suppositories. Extraction methods. Solutions for intravenous infusions. Accessory lens products. solid). 59 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 1h 1h . Examples. Examples. Divided powders. 3. Injectable solutions and suspensions with prolonged release. Emulsifying agents. 11. Extracts (fluid. Milling. Pharmaceutical suspensions. Hydrocarbon bases. Viscosity. wetting properties. Biopharmaceutical considerations. Urethral suppositories. . Auxiliary substances. Ocular baths. Large volume parenterals with electrolytes (hydro-electrolytic and acid-base balance reequilibration). Vehicles. Water and alcohol as extractive solvents. Excipients used for suppositories. Examples. Other ophthalmic solutions. Sieving-sorting. 12. emulsion and suspension ointments. Dislocation factors. Colloidal heterogeneous dispersions. Factors influencing the physical stability of fluid heterogeneous dispersions. Infusions for total parenteral nutrition. decoctions. Manual moulding. particularities. 6. Association colloids. Quality conditions achieved through formulation-preparation. Examples. Pharmaceutical powders. Examples. Interfacial energy. macromolecular compounds). Ophthalmic solutions. Vegetal products. Solution. 10. Hydrophilic colloids (hydrosoluble. Solutions for peritoneal dialysis and hemodialysis. Solid oral dosage forms. The electric charge. 2. Amphiphilic surface active substances with soluble. 4.preparations. Manufacture of emulsions. Auxiliary substances for the preparation of the suppositories. Therapeutic systems. Excipients for compressed tablets. Magistral prescriptions of medicinal substances with concentrations below or over 1%. Pharmaceutical systems with controlled release. Containers. Complexation. Examples.Nasal drops: nose drops with naphazoline chloral hydrate 0. Aseptic preparations.1% (FR X) . Characteristics and quality control.Vehicles: neutralized sunflower oil. Tolu Balm Syrup (FR X). Preparation. Injectable preparations. Lemonades. Co-solvency. . Simple syrup (FR X). Eye drops. Aqueous solutions of some non-ionized drugs. Syrups.Alcoholic solutions: the iodinated iodine alcoholic solution (FR X). Aqueous solutions of some ionized drugs obtained by dilution. zinc chloride collutorium.Injectable procaine chlorhydrate solution (FR X). 16. Quality control. .Expressing infusion drug content. Excipients. Extractive solutions 60 2h 1h 1h 2h 6h 6h 6h 3h 6h 6h 3h 6h 6h . Coated compressed tablets. . Capsules.13. Vials conditioning. . hard gelatine capsules. injectable glucose solution (FR X). Solutions. Magistral prescriptions with highly active drugs (Separanda) and with toxic and narcotic drugs (Venena). . . Intravenous infusions. Direct compression. Compressed tablets with prolonged or sustained release. Dosage forms with modified release. quality control. .single dose: ophthalmic solutions with fluorescein. 4. Coating with polymer films. Micellar solubilization. equipment.Ophthalmic solutions with atropine sulphate (FR X). injectable magnesium sulphate solution (FR X). Filling. the magnesium citrate solution (FR X) 5. Types of compressed tablets. . Formulation principles. Checking maximum doses. Solutions for external use. ophthalmic solutions with resorcinol (FR X). Avoiding the physico-chemical interactions in solution.The sodium chloride perfusion (FR X). Techniques to solubilize poorly soluble drugs. codeine syrup (FR X). . Wet granulation. with chloramphenicol. . . Characteristics. Ophthalmic preparations.Aqueous and oily magistral prescriptions.Collutoria: borated glycerine collutorium. the anisated ammonium chloride solution (FR X). Injectable methenamine solution. . the compound sodium chloride infusion with sodium lactate (FR X). Examples. soft gelatine capsules. 3. 15. the camphor alcoholic solution (FR X).Ear drops with: silver nitrate. The effervescent solution (FR X). examples. 14. technologies. Technologies and equipment. the compound sodium chloride infusion (FR X). Examples. Polymers used for coating. Role of the pH. 7. the sodium bicarbonate infusion (FR X). . Dry granulation. 2nd SEMESTER 1. with zinc sulphate.Gargles: magistral prescriptions (phenosallyl). closures and metal gasket.Recipients: containers. 2. 8.Vaginal lavages: with potassium permanganate 6. dissolution and chemical reaction of the components. Preparation technologies. Sugar coating techniques.Ear drops: magistral prescriptions . PRACTICAL LESSONS SYLLABUS 1ST SEMESTER 1. Magistral prescriptions with toxic and narcotic drugs and with vegetal extracts. Opium and ipecacuanhae powder (FR X). methylcellulose mucilage (FR X). Emulsions. Ointments. Powders with fatty substances. Magistral prescriptions with toxic and narcotic medicinal substances.Lyophile colloids: mucilages.Emulsions. Simple granules.Lyophobe colloids : colloidal silver salts .Vehicles: oil/water and water/oil emulsions. zinc oxide (FR X). starch glycerite. . . . hydrocortisone acetate (FR X).Emulsion control: determining the emulsion type .Suspensions for external use: stirring mixtures. Suppositories with metronidazole (FR X). Powders with eutectic mixtures.Emulsions for internal use: emulsions with bromoform . . Powders.suspensions.Infusions from products containing mucilages/ volatile oils/ alkaloids. phenylbutazone (FR X). Colloidal solutions. Sodium carboxymethylcellulose (FR X). Compressed tablets.Ammonium liniments.Medicinal ointments with: clotrimazole (FR X). Magistral prescriptions with efflorescent medicinal substances and oleosacchara. 5. .Powders for external use. emulsifying ointment FR X). . Magistral prescriptions. . Wet and dry gum method . A/U) .Suspensions for internal use: preparing suspensions through dispersion and condensation.Emulsions for external use: nasal drops emulsions (U/A. sodium carboxymethylcellulose).Decoctions 2. The therpine hydrate suspension.Rectal suppositories: compression moulding and manual moulding. the Petrini Paste. tragacantha mucilage (FR X) 3. . . A/U emulsions (hydrated lanolin. Magistral prescriptions (moulding and shaping). the laxative effervescent powder (FR X). 7. FR X). hydrosolubles and hydrodispersables (ointment with PEG FR X. . .Urethral suppositories. . 4. .Non-divided powders. Effervescent granules. oleo. . Preparation by moulding: suppositories with polyethylene glycols. Suppositories.Sterile ointments: ophthalmic ointment with pilocarpine (FR X). . Preparation by moulding. ointments with antibiotics (neomycin) 6. Magistral prescriptions.limestone liniments..Incompatibilities between medicinal substance and suspension agents: the bismuth nitrate suspension . 8.Direct compression using the alternative compression machine 61 6h 6h 3h 6h 6h 3h 6h . Suspensions. .Calcium glycerophosphate granules.Divided powders: the alkaline powder (FR X). Granules. .Ointment bases: anhydrous fat (simple FR X ointment.Macerations .Vaginal suppositories: the gelatinous mass. Allen L. I. Editura Dacia.. Leucuţa S.. 62 . Leucuţa S.: Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems.: Pharmacie galenique. Lippincott. Cluj-Napoca.Pasteur. 1973 3. Leucuţa S. 8th ed. 6. Popovich N. 1995 2. Universitatea L. Cluj-Napoca.E. 1997. 2000 4. 2001.C. Editura Dacia. Editura Universitară “Iuliu Haţieganu” Cluj-Napoca.: Prepararea medicamentelor.V. Masson.: Tehnologie farmaceutică industrială.G. Bonnes Pratiques de Fabrication des medicaments. Strasbourg. Ansel H. Achim M. Paris. Leucuţa S.a II-a.References 1. 7e edition..E.. Preda M. Le Hir A.E. 2008 (in editura) 5. ed.E.: Tehnologia formelor farmaceutice.: Formularea medicamentelor şi a noilor sisteme farmaceutice. ed. uronic acid pathway. oxidative deamination. prospecting. Lipid transport and storage. porphyrins. role and mechanism of action. physiology. PREREQUISITE . 4. lipoprotein metabolism. Plasmatic transport. Digestion and absorption. regulation and metabolic interrelations. Hemoglobin: functionstructure relation. Metabolism of the carbon skeletons of amino acids. 3. Metabolism of glycogen. Metabolism of acylglycerols and complex lipids. 5. Digestion and absorption. mitochondrial respiratory chain. relation with the drug. Gluconeogenesis. Glycoproteins and proteoglycans. intracellular messengers. deciphering of the molecular bases necessary for studying the drug (action. Carbohydrates metabolism. anatomy. Extra-cellular communication. Ketogenesis (metabolism of ketone bodies). Molecular mechanisms of hormone action: transduction systems. Bile acids. Observations: treatment of all metabolic pathways contains: presentation. formation of bile pigments. Glycolysis. Essential fatty acids. Biosynthesis and catabolism of purine and pyrimidine nucleotides. distribution. Peptidic structure of hormones: pituitary and hypothalamic hormones. Pentose phosphate pathway. Intermediary metabolism: basic concepts and design. hormones of 63 6h 10 h 8h 10 h 2h 6h . Metabolic position of pyruvate.CHAIR OF PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE TITLE – Pharmaceutical Biochemistry and clinical laboratory COURSE AND PRACTICAL LESSONS OBJECTIVES Accumulation of theoretical and practical knowledge indispensable for the bio-medical formation of the pharmacist. formation of ammonia and biosynthesis of urea. Cholesterol synthesis and biotransformation. essays. oxidative phosphorylation. catabolism of heme. Cellular oxidation: citric acid cycle (amphibolic significance). General pathways of biotransformation of fundamental cellular components. Biochemistry of endocrine system. absorption. Metabolism of proteins and amino acids. genetics TEACHING METHODS Interactive lectures based on video projection (animated Power Point) Practical applications EVALUATION METHODS Seminars. Metabolism of saturated and unsaturated fatty acids. Catabolism of amino-acid nitrogen: transamination. Digestion. 6. microsomial systems (importance concerning drug metabolism). cell biology. 2. antioxidant mechanisms. pathological aspects.organic and analytical chemistry. significance. therapeutical significance. Metabolism of fructose and galactose. heme biosynthesis. Eicosanoids. Lipid metabolism. practical and written exams at the end of each term TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 42 hours (42/0) Practical lessons – 42 hours (42/0) PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE SYLLABUS 1. metabolic directions. Protein biosynthesis. Conversion of amino-acids to specialized products. drug-design). The cytotoxicity of oxygen. inhibitors. C. biosynthesis. GL. Cluj Napoca. Biochimie: Vitaminele în procesele metabolice. Med. 3h 10. 5. 3. Univ. Didactică şi Pedagogică S. 2000. 2002. biochemical functions. Ileana Olteanu. Gheorghe Jebeleanu. Med. Elsevier. 2008. CK. 3h 9. Med. Universitară "Iuliu Haţieganu". 3h 7. Med. Dacia. parathyroid hormone. circulation. Second edition. 1996. Ed. "Iuliu Haţieganu". 13. Ileana Olteanu. "Iuliu Haţieganu". 7. Ed. Bucureşti. Jebeleanu. 5. 2008. Harlow. Biochemical exploration of renal function. Baznes. Vance. sciences. John W. Ed. 1994. 6. Niculina Mitrea. Hemoglobin and derivatives. KG. DeBoeck. 2005. tissular hormones. bio-transformations. absorption spectra and 3 h quantitative determination. 3h 3. Zubay. Căi fundamentale în metabolismul uman. 11. therapeutic implications. WW. Christian Moussard. applications in clinical laboratory. Gh. Biochimie metabolică. W.. 2008. Biochemistry. Ed. An Imprint of Addison Weslez Longman. Ed. Electrophoresis and dosage of 6 h plasma proteins. excretion. 8. Denisa Margina. calcitonin. Universitară "Iuliu Haţieganu". secretion. Cluj-Napoca. Ed. Ahren.A. growth factors. Med.the pancreas. 1999. Ed. Cluj-Napoca. Risoprint. Cluj-Napoca. Medecine.. Univ. Steroid sexual hormones and cortico-suprarenal hormones. Mathews. 2002. Principles of Biochemistry. Luminiţa Diaconescu. Teste biochimie. Exam 3h References 1.. Cluj-Napoca. Inc. Biochimie descriptivă. van Holde. Tumoral markers 3h 11. 6. Universitară "Iuliu Haţieganu". PRACTICAL LESSONS SYLLABUS 1. Med. 14. Plasma and urine mineral 3 h components.. DE. Srima. England. Biochimie metabolică. Exploration of lipid metabolism in clinical laboratory. 3rd Ed. Blood identification. Maria Dronca. Noţiuni de biochimie clinică. 4. ClujNapoca. ClujNapoca. 2. Brown Publishers. 10. Non-proteic nitrogen compounds from blood and urine. Oxford. Identification and quantitative determination of carbohydrates and some of their 6 h metabolites. Biochimie structurale et metabolique. endocrine dysfunctions. 1995. Parson. 2001. Roxana Lucaciu. ClujNapoca. 4. 2002. 12. Cornelia Ţărmure. cofactori enzimatici. 8. 9. Roxana Lucaciu. Hormonal explorations. 2001. Ed. Ed. 2eme edition. Biochemical tests in molecular diseases. Corina Ionescu. 2. Hepato-biliar 6 h biochemical exploration. Cristina Drugan. pharmacie. vol I. Andreea Arsene et all. Ileana Olteanu. Dominiczak. Corina Ionescu. Medical biochemistry. Investigation of blood acid-basic equilibrium. Biochemical analysis of gastric juice and cerebro-spinal liquid. Marek H. England. Observations: following aspects are treated: structure. Universitară "Iuliu Haţieganu". KE. Gheorghe Jebeleanu. 64 . Ed. Biochimie structurală şi metabolică. Vitamine şi coenzime.. Plasma proteins in the laboratory diagnosis. Ileana Olteanu. Enzime. Zn. Co). The biologic and nutritional role. Energetic food. Water pathology. proteins. Inadequate quantities effects. Biological and nutritional value. Types of lipids. Types of carbohydrates. Energetic requirements of the human body. F. Water as an environmental factor. Lipids in nutrition. Biological and nutritional value. Inadequate quantities effects. food) regarding their chemical composition and their impact on human health status and on environmental pollution. Food sources. Sanitary norms of potable water. inorganic chemistry TEACHING METHODS Lectures with Power Point presentations Practical applications EVALUATION METHODS Written exam (test and essay) Practical exam In-term verifications Bibliographic research and individual study TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 42 hours (42/0) ENVIRONMENTAL CHEMISTRY AND HYGIENE COURSE SYLABUS 1. The biologic and nutritional role. Cu. The importance of water for the human body. P. fibres). The biologic and nutritional role.5 h 1h 1h 1h 1h 2h 1h 1h . (Na. Food equilibrium and nutrition necessary (energy. Clean and residual water. vitamins. Healthy man nutrition. Air as an environmental factor. Inadequate quantities effects Fibres in nutrition. PREREQUISITE – knowledge of analytical chemistry.CHAIR OF ENVIRONMENTAL CHEMISTRY AND HYGIENE COURSE TITLE – Environmental chemistry and hygiene COURSE AND PRACTICAL LESSONS OBJECTIVES Course objectives – to acquire knowledge on the environmental factors (air. Mineral elements in nutrition. soil. Lipid sources. Inadequate quantities effects. The protein requirement. Food sources. Human – soil impact. 4. Fe. Se. glucides. Practical lessons objectives – to acquire knowledge on the methods used for the analysis of these environmental factors. Types of proteins. I. Air and health status. Inadequate quantities effects 5. 3. Carbohydrate sources. Human body requirements in fibres. mineral elements. Carbohydrates in nutrition. Human body requirements in mineral elements. Inadequate quantities effects. Ca. Mg. Food groups 65 1h 3h 0. Proteins in nutrition. Human body requirements in vitamins. Soil and health status. The lipid requirement. lipids. Vitamins in nutrition. organic chemistry. Sanitary risks due to common air impurification 2. water. Biological and nutritional value. Protein sources. The carbohydrate requirement. Sanitary risks due to polluted water. Food sources. K. Fruits and vegetables. Nutritional value of cereals and derivates. Chemical composition. Legumes. tablets. Alcoholic and non alcoholic beverages. Hygiene and toxicological aspects. Hygiene and toxicological aspects: fruit contamination. nutritional value.5 h 0. Edible fats and oils. Modifications after processing. Sugar based products made mostly of small molecule carbohydrates (refined): sugar. Classification. Nutritional and energetic value of sugar based products. Classifications. Chemical composition. Definition. Nutritional value of fats. Packing and storing. altering. Fruit based fat: olive oil. mustard and cocoa. Nutritional value of meat. Fermented alcoholic beverages. nutrients and aromatic substances. Fats obtained from oil seeds. Nutritional value of milk. cream. Meat. Meat contamination and alteration. Hygiene and toxicological aspects: legumes contamination. Milk contamination and alteration. Milk forgeries. Hygiene and toxicological aspects. fruits and vegetables based beverages. Chemical composition. Nutritional value. Nutritional value. altering. Mother and Cow milk comparison. Wheat derivates. Eggs. Sanitary aspects. Functional aspects. Hygiene and toxicological aspects: alimentary fat contamination. Sanitary aspects. Milk derivates: fermented milk products. Therapeutic effects. prevention measures. Alcohols. Alteration and conservation. Sanitary and toxicological aspects. marmalade. The hygiene of pharmaceutical units 66 2h 1. Vegetables contamination. Vegetal fats. Contamination and altering. Altering and prevention. Nutritional Value. Chemical composition and nutritional value Effects of abuse. nutritional and caloric value-. Vinegar and organic acid condiments.5 h 1h 1h 0. Sanitary aspects. Sanitary aspects. storing and prevention measures.5 h 2h . Derivates. chewing gum. Vegetables. Sanitary aspects. Chemical composition: carbohydrates. Chemical composition and nutritional value. Fish. Nutritional value of egg. altering and contamination. altering and storing. Honey. 6. Fruits. altering. Classification. Sanitary aspects. Distilled alcoholic beverages – spirits. nougat fillers. coffee sodas. Frauds and forgeries. prevention measures. marzipan. nitrogen based compounds. Chemical composition of egg. Milk – definition. butter. and croquants. Sensory aspects of fish: smell. Classification. Nutritional value of egg. Chemical composition. Chemical composition of vegetal fats. Nutritional value of fish.5 h 1h 2h 2h 0. Non alcoholic beverages: tea. Sugar based products made of sugar and oil seeds: chocolate . Meat classification. Chemical composition. Hydrogenate fats: margarine. Sanitary aspects. refreshments. Animal fats. cheese. Meat products. Sugar substitute and artificial sweeteners.5 h 1. texture. structure and properties. Complex mixtures: ice-cream. Sanitary aspects.types. Other alimentary fats. Chemical composition and nutritional value. Chemical composition of meat. Cereals and cereal products. jellies. Soybean and soy proteins derivates. Sugar and sugar based products. Optimal quantities and effects of abuse. Other derivates. Classification. Salt. Sugar based products made of sugar and fruits: jam. Chemical composition. Digestibility. Condiments and spices. Nutritional value of dairy products. Definition. Chemical composition. candy. Structure of muscle tissue. Sanitary aspects. Sanitary aspects. dragées. Milk and dairy products. Structure of cereal grain. properties. Chemical composition. 2h 2. References 1. 1998 11. 2a ed. Gabriele Steiner – Analisis de los alimentos. 5h 6. Analysis of water impurifying components. 1998. H.S. flour gluten.Igiena. distilling method Dean-Stark. Ed.PRACTICAL LESSONS SYLLABUS 1. Medicală. Belitz. D. 2000 67 . Spain. augmentada. „Iuliu Haţieganu” Cluj-Napoca. Vreden – Elementos de Bromatologia descriptiva. G. Univ. Bertrand method. Springer. G. Security and personal safety in the chemistry laboratory. 3. vol 1. Presses Universitaires de Lieges A. Zenova Bărduţă. Karl-Fischer) Determination of carbon hydrates in aliments. Aliment analysis based on their groups. Schnepel. Disinfection process for potable water. Chemical-sanitary analysis of water. J. forgeries. S. General methods (Soxhlet) and specific methods (Gerber) Determination of water content of aliments (gravimetric method. 13 h Analysis of normal water constituents. vol 2. Doina Şendrea. Ed. Ed.. 2007 3.Ghid de analiză chimico-sanitară a mediului – Litografia UMF Cluj-Napoca. Gutierrez – Ciencia Bromatologica – Principios generales de los alimentos. Dumitrescu. Gh.L. Canada. Tănăsescu. Spania. Fouassin.P. Otawa. Frank-M. Mănescu. Determination of vitamins in aliments. Me. Universidad de Granada. Diaz de Santos. Spania. A. H. S. Chemical-sanitary analysis of air. Schenker. Doina Miere – Chimia şi Igiena alimentelor. 21 h biological constants. Fundamentos. Cucu .. General aspects. Chemical-sanitary analysis of soil 5. Zaragoza. 1999 10. Ed. 1996 5. ACRIBIA. Analysis Methods. E. W. Reinhard Matissek. 1996 4. A. Schoorl method. W. Doina Miere . Berlin. ACRIBIA. M. Dumitrache. 7. Chemical-sanitary analysis of aliments. Me. lactose determination using Ionescu-Matiu method. Metodos. S. Lipid determinations. Mănescu. Aplicationes.Yufera – Quimica de los alimentos – Editorial Sintesis. 1982 6.J. iodine method. Mona Ligia Diaconescu – Chimia sanitară a mediului. J. G. CO2 4.B.D. Minerals determinations. Ontario. Ad. Josst. Ed.M. Grosch – Food Chemistry. Mataix Verdu – Tabla de composition de alimentos espanoles. Ed. Zaragoza. Elsevier. 8. Pare. Belanger – Instrumental methods in food analysis. „Iuliu Haţieganu” Cluj-Napoca. 1995 12. Determination of normal compounds of 1 h common air: O2. Univ. Ed. Noirfalise – Methodes d’analyse des substances alimentaires 4me edition. J. Bucureşti. J. determination of normal compounds. Medicală. 1997 9. Doina Miere – Chimia şi Igiena alimentelor. 7. Sturm N. Ed.R. Ashes determinations. Determination of polluting compounds: pesticides heavy metals. Determination of normal composition of aliments: Protein determination: general methods (Kjeldahl method) and specific methods: milk casein. freshness state. 1999 13.R. 2002 2. Bucureşti. Vollmer. Acute renal failure. physiopathology TEACHING METHODS Lectures with Power Point presentations Practical demonstrations at patient’s bedside EVALUATION METHODS Written exam Practical exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 42 hours (0/42) Practical lessons – 28 hours (0/28) Clinical pathology COURSE SYLLABUS 1. Thombophlebites 4. Cardiovascular semiology Cardiovascular semiology . chronic tracheo-bronchitis. Lung thrombo . Pleurisy. Basic concepts in general semiology 2. Chronic obstructive bronchopathy Asthma Pneumonia. Respiratory semiology Respiratory semiology . Lung cancer. Practical lessons – to observe.notions Acute gastritis. Chronic pyelonephritis.notions Acute articular rheumatism. Pulmonary suppuration. Nephritic syndrome. Surgical 68 9h 8h 10 h 3h 9h . Interstitial nephropathies.CHAIR OF SEMIOLOGY AND INTERNAL MEDICINE – IV MEDICAL CLINIC COURSE TITLE – Clinical pathology COURSE AND PRACTICAL LESSONS OBJECTIVES Course: To acquire knowledge and understanding of the main diseases with the purpose of a better understanding of drug therapy. at patient’s bedside.notions Acute tracheo-bronchitis. Valvulopathies. lung emphysema. 3. physiology. the signs and the para clinical explorations important for the diagnostic of the disease PREREQUISITE – knowledge of anatomy. Endocarditis. Renal semiology Acute post-streptococci glomerulo-nephritis. Atherosclerosis. Digestive semiology Digestive semiology . Ischemic cardiopathy Arterial hypertension Arrhythmia Cardiac failure Choc. Acute pyelonephritis. Chronic renal failure.embolism. Chronic gastritis. Chronic glomerulo-nephritis. Gastric and duodenal ulcer. 5. 1998 2. R. Cardiovascular semiology 6h 4.Bolosiu. Hepatic cirrhosis. Dorel Simpelean. Collagenosis 2h 7.Urgente Medico-Chirurgicale pentru Farmacisti.2 – editia a 14 – a in limba romana. Cluj Napoca. 2001 6. Sjogren Syndrome. Anton Draghici. PRACTICAL LESSONS SYLLABUS 1. 2001 4. Editura National. 2008 69 . 2005 3. Haemorrhagic diathesis.stomach. Principii de Medicina Interna – volumul 1. Haematopoietic system 2h References 1.J. London. Casa Cartii de Stiinta. Pathology and Therapeutics for Pharmacists. Medullar failure. Mircea Cazacu. Pascu. Tumours of the stomach. Ake Andren-Sandberg. 2001 7. Sorin T. Cluj Napoca.Greene. Esentialul in Gastroenterolgie si Hepatologie. Non specific chronic entheropathy. Acute leucosis. Malabsorption syndrome. Acute entero colitis. N. Casa Cartii de Stiinta. Chronic leucosis. 6. Pancreatic Disease in 2008. Scleroderma.D. Vasile Negrean. 2000 5. Semiologie Medicala. Haematopoietic system 2h Anemias. Medical semiology notions 4h 2. Acute and chronic angio-colecistopathies. Rheumatoid 1 h polyarteritis 8. Medicina interna pentru Stomatologi. Digestive semiology 6h 6. Bile lithiasis. Harrison. Barbu. Cluj Napoca. Vasile Negrean.Harris. Respiratory semiology 6h 3. H. Haemorrhagic rectocolite Chronic hepatitis. Casa Cartii de Stiinta. Diabetes 1h 7. Renal semiology 2h 5. Anton Draghici. O. Collagenosis: LED. Cluj Napoca. Metabolic diseases.D. antibodies. Immunological techniques. properties. 12. 11. 7. on mechanisms of inflammation and on the principles of immunotherapy. clinical cases presentation EVALUATION METHODS Written exam TEACHIN LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (0/28) Seminary – 14 hours (0/14) IMMUNOLOGY COURSE SYLLABUS 1. Seminaries: To understand the immunological and immunogenetic techniques PREREQUISITE – knowledge of physiology. Cellular cooperation. as well as knowledge on specific defence mechanisms. CMH. Complement system. anaemia) 2. BAI classification 70 2h 4h 2h 2h 2h 2h 2h 2h 2h 2h 2h 4h 2h 2h 1h 1h 2h 2h 2h . 10. pathological aspects (pathological TS. 9. molecular mediators of immune response. normal TS). Inflammation. 4. 3. Auto-immunity – mechanisms. transgenic animals. 6. mechanisms. Molecular structure of membrane. 5. CD markers and immuno-receptors. principles of diagnostic. bacteriophages libraries. Cytokines. L. pathophysiology. mechanisms. Lymphoid organs. cell biology TEACHING METHODS Lectures with Power Point presentations Discussions. Immunotherapy SEMINARIES SYLLABUS 1. Drug allergies – general presentation. Antigens. 2. Immunoglobulins. Defence mechanisms of the organism 3. The means of interaction between the elements of immune system. Monoclonal antibodies – definition. Hypersensitivity reactions – classification. Tr. 7. DNA recombinant technique. 4. Case study – allergology (allergy test) 6.CHAIR OF IMMUNOPATHOLOGY COURSE TITLE – Immunology COURSE AND SEMINARY OBJECTIVES Course: To acquire knowledge on the constitutive elements of immune system and the interactions between them. Clinical case study (beta-lactamines allergy). 8. Blood cells physiological aspects (H. Specific defence mechanisms 5. clinical signs. clinical applications in diagnostic and treatment. Drug Hypersensitivity. 2006 6. Ed. 8.Univ. 2007.Med.Med. Cristea V. Ed. Pichler W J. Crisan M.(organ-specific and non specific). Bolile Atopice. Dumitrascu D. CrisanM. Ed. Imunologie Clinica. 2002 5. Mega. Imunologie Fundamentala. Tratat de Imunoterapie.Univ. 1h 9. Med. Doru Dejica. `Iuliu Hatieganu` Cluj-Napoca. Auto-immunity disease . 2004 3. Ed. Ed. Cristea V. Karger.Univ. 2004 2. Cristea V.`Iuliu Hatieganu`. Immunodeficiencies – classification. 71 .clinical case presentation. Adverse reactions to biological products. Clinical case presentation (AIDS). Esentialul in Imunologie.Casa Cartii de Stiinta. ClujNapoca. 1h References 1. `Iuliu Hatieganu`. Ed. Cluj-Napoca. Crisan M. 2002 4. ClujNapoca. Drug excretion 5. Cholinergic transmission 11. Pulmonary and digestive drug absorption 4. Adrenergic transmission 10. needed for the understanding of the pharmacology of the main classes of drugs Practical lessons: the study of experimental models used for the evaluation of the pharmacokinetics and pharmacology of drugs. physiopathology. Parenteral drug absorption. Molecular action of drugs 7. physiology. instruments. Drug metabolism and excretion 5. Drug distribution 4. Drug-dependent variability factors in pharmacodynamic activity 72 1h 2h 2h 2h 3h 3h 1h 2h 1. Pharmacovigilence and pharmacoepidemiology 9. Pharmacokinetic phase. Pharmacokinetic phase.5 h 1. Histaminergic transmission 12. Drug absorption 3. Cutaneous and ocular drug absorption 3. PHYSIOLOGY AND PHYSIOPATHOLOGY COURSE TITLE – Pharmacology COURSE AND PRACTICAL LESSONS OBJECTIVES Course: Acquiring knowledge of general pharmacology. addictions. Phases of drug evolution in the human body.5 h 2h 1h 2h 2h 3h 2h . Introduction. pathology and biochemistry TEACHING METHODS Interactive lectures Experiments on laboratory animals and computer alternative methods EVALUATION METHODS Written exam Practical exam TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 14 hours (0/14) PHARMACOLOGY COURSE SYLLABUS 1. reactions at drug treatment discontinuation 8. Other transmissions PRACTICAL LESSONS SYLLABUS 1. Pharmacokinetic phase. Pharmacodynamic phase. laboratory animals 2.5 h 2h 2h 1. Pharmacodynamic phase. PREREQUISITE – knowledge of anatomy.CHAIR OF PHARMACOLOGY.5 h 1. Introduction. intolerance. Pharmacotoxicology: tolerance. Glutamate transmission 14. The parameters of pharmacodynamic activity and the factors influencing pharmacodynamic activity 6. Biopharmaceutical phase 2. GABAergic transmission 15. Serotoninergic transmission 13. Katzung B. 2007. Schorderet M. 11. Ed. Pharmacologie. Aurelia Cristea. Editura Medicală Bucureşti 2005.M. Farmacologie generală. Ed. Bazele experimentale ale farmacologiei. Frison-Roche. 10. Pharmacology. Mc Graw Hill. Ed. Mogoşan Cristina. Ed. 8. Editura Medicală Universitară „Iuliu Haţieganu” Cluj-Napoca 2005. Pharmacodynamic antidotism 1h References 1. Basic and Clinical Pharmacology. Organism-dependent variability factors in pharmacodynamic activity 3h 7. Editia a 10-a. Tratat de Farmacologie. Gies J-P. Churchill Livingstone..M. 2. 2001. Goodman&Gilman’s. des cibles vers l’indication therapeutique. Dunod. Mogoşan Cristina. Editura Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. New York 2007.6. Editura McGraw-Hill.. Ed. Abrégé de PHARMACOLOGIE. Ediţia a VII-a. Cohen Y. 73 . Masson. 4. Rang H. Didactică şi Pedagogică Bucureşti. Bazele farmacologice ale practicii medicale.. Aurelia Cristea.G.. Dale M.P. Voştinaru Oliviu... 3. Editura Medicală.. Des concepts fondamentaux aux applications therapeutiques.. Paris. Ritter J. 5. 1998. The pharmacological basis of therapeutics. 2003.. Pharmacologie. 2001. 6. Jacquot C. 2005. Landry Y. Ghibu Steliana. Slatkine Geneve 1992. 9. 2006. Pharmacologie. Valentin Stroescu. Ed. 7. B. 2000 4. inorganic chemistry. 2002 3. Lacroix – Terminologie médicale. analytical chemistry. Thieulle – Pratiques du mot médical. Editura Polirom. physical chemistry. physiology.CHAIR OF TOXICOLOGY COURSE TITLE – Applied pharmaceutical terminology SEMINARIES OBJECTIVES Acquire knowledge of medical and pharmaceutical terminology during activities such as: correct analysis of components of medical and pharmaceutical terms. Bucureşti. Learning specific pharmaceutical terms by exercises: word construction. analysis of scientific texts with the purpose of a good comprehension and interpretation. Learning specific medical and pharmaceutical terms by exercises: word 6h construction. 2nd year pharmaceutical terminology TEACHING METHODS Discussions and exercises EVALUATION METHODS Written exam TEACHING LANGUAGE English language NUMBER OF HOURS Seminary – 28 hours (0/28) APPLIED PHARMACEUTICAL TERMINOLOGY SEMINARY SYLLABUS Ist SEMESTER – APPLIED MEDICAL TERMINOLOGY 1. classification of words with the aid of operating unit. identification of specific terms in scientific papers and explanation of their meaning. Terms used in dermatology Terms used in ophthalmology Terms used in stomatology Terms used in ORL 2. Lupuleasa – Terminologie medicală şi farmaceutică. crossing words. IInd SEMESTER – APPLIED PHARMACEUTICAL TERMINOLOGY 1. Lăcrămioara Ochiuz. Iuliana Popovici. References 1. identification of specific terms in scientific papers and explanation of their meaning. 2007 2. exercises of correspondence between the terms and their significance. D. Des articles scientifiques de la littérature de spécialité 74 . PREREQUISITE – knowledge of anatomy. 2. exercises of correspondence between the terms and their significance. Cahier d’exercices. 6h classification of words with the aid of operating unit. The analysis of scientific texts with the purpose of getting the skills of good 8h comprehension and interpretation of medical and pharmaceutical terms. Editions Casteilla. Editions Lamarre. RueilMalmaison. Méthode et activités. organic chemistry. crossing words. The analysis of scientific texts with the purpose of getting the skills of good 8h comprehension and interpretation of pharmaceutical terms. Paris. J. . economical importance and use of different fungal species. Milan. recognition and differentiation of edible and toxic mushrooms PREREQUISITE – high school level general biology TEACHIN METHODS Lectures with Power Point presentations EVALUATION METHODS Written examination (standard type or MCQ – multiple choice questions) TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (14/0) MYCOLOGY COURSE SYLLABUS 1. 75 .CHAIR OF PHARMACEUTICAL BOTANY COURSE TITLE – Mycology COURSE OBJECTIVES Acquiring knowledge regarding: general characters of domain Mycophyta. 1985. PARVU M. Barcelone. pathogen fungal species. Fungi used in pollution control. Fungi as source of pharmacological active principles 5. Ceres Bucureşti. economical use. Clujeană Cluj-Napoca. Ed. CONTET-AUDONNEAU N. 1999. Pathogen moulds 1h 6. CHABASSE D. Medicală Bucureşti. VILLARD J. 1999. Masson Paris. Edible mushrooms.: Mycologie médicale.: Botanică sistematică vol.Gloria Cluj Napoca. Ed. Fungi used in 4 h biotechnologies. 7. vitamins.I. Yeast – source of proteins.. PARVU M. Presa Univ. Masson Paris. LUCA MARIANA: Parazitologie şi Micologie medicală. 5.. 2 h Recognition criteria and first aid 4. 3. 1999. GUIGNARD J. Recognition criteria and nutritive value. 1995. 1997. General characters and classification of domain Mycophyta 1h 2. BOUCHET PH. Ed.: Mycologie fondamentale et appliquée. Ed. Liber SA Geneve.: Atlas micologic. Ed. 4. Toxic mushrooms. SLEZEC ANNE-MARIE: Les Champignons. 6. Phytopathogen mushrooms 1h References 1.: Determinator pentru recunoaşterea ciupercilor comestibile şi otrăvitoare din România. 2003 2. Fungi as human pathogens. Antimycotic substances 1h 3.-L. GUIGUEN CL.. SALAGEANU GH.. SALAGEANU A. M. chemistry.F. Prosthetic devices for hands and legs diseases. The importance and the role of prosthetic devices in pharmaceutical 2 h practice. 2000 2. Tipografia U. physiology. Cooperation Pharmaceutique Francaise. Prosthetic treatment of varicosity. 2h 6. 2h 4. Varicosity and their treatment. Laroche C. 2h References 1. 76 . explanations and discussions Individual study and documentation EVALUATION METHODS Written test Compilation and presentation of papers on a given topic TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (14/0) PROSTHETIC DEVICES COURSE SYLLABUS 1. 2h 5. Laroche J. Ed. 2h 3. Various vertebral diseases and their prosthetic treatment.. 2. Paris. Produse protetice. Cluj-Napoca. Rosca M. Prosthetic devices classification. 1988.. physiopathology. Supply materials for prosthetic products. physics TEACHING METHODS Interactive lectures. Leçons d'orthopedie.CHAIR OF MEDICAL DEVICES COURSE TITLE – Prosthetic devices COURSE OBJECTIVES Acquiring knowledge on prosthetic devices available in pharmacy PREREQUISITE – knowledge of anatomy. Various abdominal diseases and their prosthetic treatment. : Medicamentul de-a lungul vremii. 1995 3.: Pharmacy an ilustrated history. The Antiquity 1h Pharmacy in the Antique Greece 1h Pharmacy during the Hellenistic period 1h Pharmacy during the Roman Empire 1h Pharmacy during the Medieval Epoch 1h Pharmacy during the Renaissance 1h Pharmacy in Modern times 1h The contemporary history of Pharmacy 1h The Romanian history of pharmacy 1h References 1. 1990 77 . New York. Izsak S. The Prehistory 1h Pharmacy in the Antique Egypt 1h Pharmacy in Mesopotamia 1h Pharmacy in India and China. 1979 2. Inc. Helfand W. art and science PREREQUISITE .. Ştiinţifică şi Enciclopedică.. Cotrău M. Bucureşti. Abrams.none TEACHING METHODS Lectures with Power Point presentations EVALUATION METHODS Written examination TEACHING LANGUAGE Romanian language French language English language NUMBER OF HOURS Course – 14 hours (14/0) HISTORY OF PHARMACY COURSE SYLLABUS Introduction.: Farmacia de-a lungul secolelor. L. Cowen D. H. Harry H.CHAIR OF PHARMACOGNOSY AND PHYTOTHERAPY COURSE TITLE – History of pharmacy COURSE OBJECTIVES Acquiring knowledge on the evolution of pharmaceutical practice in the context of universal history and the history of civilisations. Ed. Publishers. Ed. Apollonia Iaşi. * 30 hours/week – 2 weeks References 1. Tollage and registration of prescriptions. delivering drug formulas and pharmaceutical specialties. The qualitative. Filling the practice notebook Oral exam TEACHING LANGUAGE Romanian language French or English language for foreign students that perform the practice in their own country NUMBER OF HOURS 30 h / week . Adequate professional relations with the staff of pharmacy and patients. analysis of how to solve real professional problems EVALUATION METHODS Characterization of student’s work by the coordinating pharmacist regarding: 1. 2008 78 . Nomenclatorul de medicamente şi produse medicamentoase de uz uman. 3. Farmacopeea română. discussions. Involvement in the pharmacy activity 4. Bucureşti. storage in appropriate conditions. X. Editura Medicală. Agenda medicală. Effective participation in the preparation of pharmaceutical preparations 2. Agenţia Naţională a Medicamentului. 3. under the coordination. informatics TEACHING METHODS The application of theoretical knowledge in pharmacy practice. quantitative and value reception of drugs. The attitude towards the staff of the pharmaceutical unit. Knowing pharmaceutical specialties. Editura Medicală. 5. monitoring and verification of practice tutors pharmacist Explanations. Ed. Memomed. 1993 2. pharmaceutical technology. Bucureşti. Compliance with the internal rules of organization and conduct of work. Editura Minesan.CHAIR OF MEDICAL DEVICES COURSE TITLE – Summer practice for the 3nd year students in pharmacy COURSE OBJECTIVES Acquiring knowledge and practical skills on the preparation of pharmaceutical formulations and filling the documents needed for their preparation and delivery Acquiring adequate knowledge regarding pharmaceutical substances and pharmaceutical specialties Acquiring adequate skills for the communication with patients PREREQUISITE – knowledge of IPhTL. 2008 3. Frequency 2. Bucureşti. 4.2 weeks (0/60) SUMMER PRACTICE FOR THE 3ND YEAR STUDENTS IN PHARMACY PRACTICE SYLLABUS 1. 2008 4. pharmaceutical chemistry. Bucureşti. use of certain methods to establish the chemical structure-activity relationships PREREQUISITE – knowledge of inorganic chemistry. The objectives of the practical lessons are as follows: .structural elements important for the therapeutic class .synthesis and identification of active biological compounds .use of chemical and physico-chemical methods for the medicinal substances identification and assay . The cardiovascular system Antihypertensive drugs Antianginal drugs Cerebral and peripheral vasodilators Antiarrhythmics Cardiotonics Normolipemiant drugs 79 10 h 1h 13 h .chemical structure . The vegetative nervous system Adrenergic agonist drugs Adrenergic antagonist drugs Cholinergic agonist drugs Cholinergic antagonist drugs 2.activity relationships . organic chemistry.metabolic biotransformations influencing therapeutic activity . chemical and therapeutical interactions. physiology. biochemistry TEACHING METHODS Lectures with Power Point presentations Practical applications Debates on a given subject Review presentation EEVALUATION METHODS Written examination Practical examination Periodical verifications Independent work on a given subject TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 84 hours (42/42) Practical lessons – 84 hours (42/42) THERAPEUTICAL CHEMISTRY COURSE SYLLABUS 1st SEMESTER 1. pharmaceutical products.main therapeutic effects indications.physico-chemical properties important for the pharmacodynamic activity and stability .application of some chemical methods into the medicinal substances synthesis .CHAIR OF THERAPEUTICAL CHEMISTRY COURSE TITLE – Therapeutical chemistry COURSE AND PRACTICAL LESSONS OBJECTIVES The objectives of the course are to acquire knowledge on: . Neuromuscular blockers 3. analytical chemistry. anatomy. side effects. Antiallergic drugs Histamine and antihistamines H1 Inhibitors of histamine release 2. The respiratory system Antitussive drugs Mucolytic and expectorant drugs Anti-asthmatic drugs Respiratory analeptical drugs 7. The digestive system Gastric secretion inhibitors Proton pomp inhibitors H2 antihistaminic drugs Antiacide drugs Cytoprotective drugs Prokinetic drugs Antiemetic drugs Hepatoprotective drugs Antidiarrheals drugs Laxative and purgative drugs nd 2 SEMESTER 1. Substances used for diagnosis 2h 2h 6h 8h 4h 14 h 4h 8h 8h 3h 1h 80 . haemostatic drugs 7. Opioid analgesic drugs Morphine Semi synthetic analogous: agonists and antagonists Synthetic analogue substances: agonists and antagonists 4. antithrombotic.4. Local anaesthetics 6. Antianemic. Diuretics 5. antipyretic and non steroidal anti-inflammatory drugs Analgesics and antipyretics Non steroidal anti-inflammatory drugs Slow-acting antirheumatics Antigout drugs 5. Central nervous system Central myorelaxante drugs General anesthetic drugs Sedative and hypnotic drugs Antianxiety drugs Antipsychotic drugs Antidepressants drugs CNS exciting drugs Antiepileptic drugs Antiparkinsonian drugs Antimigraine drugs 2. semi-synthetic and synthetic analogous Polypeptidic hormones Insulin and oral antidiabetic drugs Thyroid hormones and anti-thyroid drugs Corticosteroid hormones and semi-synthetic and synthetic derivatives Sexual hormones 6. Analgesic. Hormones. VICTORIA F. MICHAELA PITEA. Paris. 2004. OVIDIU CRIŞAN. Ed. ANA MUREŞAN. DAVID A. The organic Chemistry of drug Designe and Drug Action. Medicaţia în bolile cardiovasculare. ZAHARIA VALENTIN. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. 9. MICHAELA PITEA. 5. 7. Textbook of Organic Medicinal and Pharmaceutical Chemistry. Dacia. Dacia. 2004. LEMKE. Colecţia “Biblioteca farmacistului” 1998. RICHARD B. ANA MUREŞAN.SIMITI. Chemical and physico-chemical characterization of medicinal substances belonging to the following chemical groups: Amines 9h Carboxylic acids. I. Vol. their identification and assay: Benzocaine 6h 2. Ed. Medicaţia în osteoporoză. 6. ANA MUREŞAN. ZITO. ANA MUREŞAN. Medicală Universitară “Iuliu Haţieganu” Cluj -Napoca. Chemical and physico-chemical characterization of medicinal substances belonging to the following chemical groups: Polyhydroxy aldehide (ketone) 3h Cyclic ureides 3h Pyrazolone. ANA MUREŞAN. Ed. 8. pyrazolidindione 3h Fenothiazines 3h Benzodiazepines 3h Alkaloids 3h Xantines 6h Vitamins 3h Hormones 3h 2. THOMAS NOGRADY. 2003. AFECT-Traité de Chimie Thérapeutique. MARIANA PALAGE. Oxford University Press 2005. Synthesis of some medicinal substances. 3. JOHN H. BLOCK. Structural modelling 6h 2nd SEMESTER 1. WILLIAM S. DOINA GHIRAN. Medicamente antiinflamatoare nesteroidiene. phenol acids and their salts 3h Amides 3h Amino acids 3h Alkaloids 9h 1. . 4. DOINA GHIRAN. Médicales Internationales. SILVERMAN. Lippincott . Ed.Williams&Wilkins. Colecţia “Biblioteca farmacistului” 1997. JOHN BEALE. Philadelphia. Lippincott Williams&Wilkins. WEAVER. salts and esters 3h Alcohol acids. Second Edition. Synthesis of some medicinal substances. WILLIAMS. Medicaţia afecţiunilor sistemului nervos central. THOMAS L. 1998. Philadelphia. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. 2008. 10.3. ROCHE. Structural modelling 6h References 1. Ed. Foye’s Principles of Medicinal Chemistry. Cluj-Napoca. their identification and assay: Calcium lactate 6h 3. 2005. 2003. Sixth edition. DONALD F. MARIANA PALAGE. 81 .PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1.4. Medicinal Chemistry a Molecular and Biochemical Approach. Ed. Produşi naturali heterociclici. Cluj-Napoca. MARIANA PALAGE. 2. Elsevier. Eleventh Edition. 1. CHAIR OF PHARMACEUTICAL TECHNOLOGY COURSE TITLE – Industrial pharmaceutical technology COURSE AND PRACTICAL LESSONS OBJECTIVES Acquiring knowledge on formulation, pharmaceutical technology and quality control of industrial pharmaceutical dosage forms, with the purpose of registration by the national regulatory agency and for efficient and safe use in patients PREREQUISITE – knowledge of chemistry, physics, physical chemistry, biology TEACHING METHODS Lectures with Power Point presentations Practical applications EVALUATION METHODS Practical exam Written exam with multiple choice questions TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 56 hours (28/28) Practical lessons – 84 hours (42/42) INDUSTRIAL PHARMACEUTICAL TECHNOLOGY COURSE SYLLABUS 1st SEMESTER 1. Drug design. Drug dosage forms. Preclinical and clinical studies. Formulation. Production. Quality. Good Manufacturing Practices. Quality Control. Validation. 2. Optimization of the formulation and technology of drug dosage forms. Design of experiments. Methods of optimization. Examples. The importance of optimization in the preformulation. 3. Drug stability. Chemical kinetics and drug stability. Degradation of drugs, mechanisms, factors and methods to avoid degradation during preparation of the dosage form. Shelf life. Accelerated testing of stability and shelf life period. 4. Drug contamination. Microbial, chemical and mechanical contamination. Sources of contamination. Risks. Methods for avoiding contamination. The relative innocuity of drugs. Preclinical research of drug toxicity. Local tolerance. 5. Drug efficiency. Phases of clinical drug research. Introducing new drug dosage forms in therapeutics. Bioavailability and bioequivalence for generic drugs. 6. Solutions. Preparation of solutions, technologies, equipment. Obtaining distilled water in drug industry. 7. Mixing solutions. Industrial mixing devices. Filtration. Industrial filters. Filling recipients, methods and equipments. Industrial preparation of syrups and aromatic waters. 8. Formulation of ophthalmic drugs. Industrial preparation technologies. Equipment. Formulation of extractive solutions. Physico-chemical factors influencing extraction. Industrial extraction methods. Equipment. Quality of extractive solutions. 9. Parenteral dosage forms, formulation of injectable solutions and infusions. Washing, sterilization, depyrogenation of containers and closures; equipment. 10. Sterilization principles. Sterilization methods. Sterilization equipment. Aseptic preparation. Aseptic (clean) rooms. European guidelines for construction and functioning of the clean rooms. Validation of sterilization methods. Sterility control. 11. Apyrogeneity. Pyrogens; structure, properties; methods for removal and methods for pyrogen destruction. Avoiding pyrogenis. Control of pyrogens. The LAL test. Quality of parenteral dosage forms. 82 2h 2h 2h 2h 2h 2h 6h 2h 2h 2h 2h 12. Colloids, emulsions, suspensions. Composition and preparation technologies. Equipment. Homogenization. Quality control. 13. Topical preparations: ointments, gels: formulation, preparation, quality. Equipment for industrial preparation of semi solid preparations. Suppositories: formulation, preparation, quality. Equipment for industrial preparation of suppositories. 14. Medicinal aerosols: formulation, preparation, quality. Conditioning and preparation equipment. 2nd SEMESTER 1. Drying. Psychrometry. Stages in the drying of solids. Drying equipment. Drying by means of convection, static convection, dynamic convection (tunnel, fluidized bed); drying by means of conduction (vacuum, tunnel). Drying by means of radiation (microwaves). Dryers for solutions, suspensions (spray driers, freeze driers). Lyophilization: theory, equipment, techniques, advantages, applications. 2. Milling. Energy spent for size reduction; laws. Comminution, milling and micronization equipment. Cutting. Compressing. Impact milling. Friction. Combined methods. Choosing a method. 3. Particle size analysis. Equivalent diameters. Methods for measuring particle size. Sieves. Microscopy. The Coulter Counter. Methods for laser beam diffraction. Sedimentation methods. Separation methods: sieving; airflow separation methods, elutriation; separation cyclones. Methods of graphic representation for the distribution of granulometric classes of particles. 4. Powder rheology. The flow-cohesion relationship. The Jenike Cell. The Mohr Diagram. Indicators of particle cohesion. Shearing force. Angle of repose. Properties of particles and of powder beds. Porosity. Orifice flow. Building of the feeding basket. Characteristics of powder flows, density of powder beds, the Carr index, the Hausner index, the angle of repose. Flow modification in feeders. 5. Mixing. Mixing mechanisms. Measuring of mixing degree. Segregation. Powder homogeneity. Ordered powders. Industrial mixing: rolling, high speed agitation, etc 6. Compaction and compression. Formulation. Preformulation. Tablet presses. Single punch press. Rotary press. Granulation. Methods. Wet and Dry granulation. Mechanisms of particle binding. Mechanisms of granule formation. Granulation equipment. Planetary and oscillatory mixers, high speed granulation. Spray drying. Extrusion, spheronization. Dry granulation: slugging, compacting 7. The physics and dynamics of compression. Changes in powder bulk compression. Forces involved in the compression process. Role of lubricants. Force-displacement compression diagrams. Tests for compressed tablets quality control, pharmacopoeias and production quality control. 8. Tablet coating. Sugar coating. Stages. Equipment. Film coating. Polymers, solvents, plasticizers, colours. Requested film qualities. Coating equipment. Quantity of coating polymers needed. Film quality control. Disintegration, dissolution. Compression coating. 9. Capsules. Hard gelatine capsules. Methods of capsule production. Capsule filling. Powder dosage: screw devices, dosimeters, disk dosimeters. Equipment. Soft gelatine capsules. Preparation. The Scherer Procedure. Capsule quality, quality control. Microcapsulation, techniques, utility of microcapsules. 10. Pharmaceutical forms with extended release. Pharmacokinetic principles. Preparation technologies. Forms of the reservoir type (compressed tablets, pellets). Forms of the matrix type (hydrophyls, lipophyls, and thermoplastic polymers). Formation of salts and complexes with poor solubility. Other techniques. Quality control. 11. Pharmaceutical systems with controlled release. Principles. Characteristics. 83 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h 2h Polymers. Systems with pre-programmed release (therapeutic systems of the matrix type, reservoir type or with closed microcompartments). Activated systems (physically activated: osmotic pressure, electro mechanic, hydrodynamic; mechanic activation, magnetism, iontophoresis, floating, bioadhesive, enzymatic, etc.); systems with feed-back release. Drug targeting. Microparticles for passive targeting (liposomes, nanospheres, microspheres). Soluble macromolecular carriers. Monoclonal antibodies. Endo and transcytosis. 12. Packaging. Packaging materials: glass, plastic materials, metals. Properties. Unit dose packaging. Industrial equipment. Quality conditions. Uses. 13. Introducing new drug dosage forms on the market. Guidelines. Application files. 14. The concept of quality assurance. Good Manufacturing Practice. Quality Control. Validation. Good Laboratory Practices. Good Clinical Practices. PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. Aqueous solubility of drugs. Particle size influence on dissolution 2. Influence of the pH and of co solvents on the solubility of weak acidic drugs (phenobarbital). 3. Preparation of intravenous infusions. Preparation of distilled water; weighting raw materials, dissolution, flask distribution, sterilization. 4. Quality control of infusions: clarity, pH, concentration, sterility, pyrogens (the LAL test). 5. Determination of the parameters that characterize the sterilization process: decimal reduction time, inactivation factor, Z-value, lethality level, F-value, sterilization value. 6. Alcoholic extractive solutions. Determining the influence of the method used for extraction (maceration, percolation, turboextraction) and of solvent concentration (alcohol 50˚, 70˚, 96˚) on the effectiveness of the extraction from vegetal products (Calendulae flos). 7. Preparation and quality control of deflocculated suspensions. Determination of the stability of the suspensions according to the viscosity of the dispersion phase, the presence of an agent for increasing viscosity, the presence of a surface active agent. Determination of the sedimentation rate. 8. Preparation and quality control of flocculated suspensions. Using the agar- agar gel as flocculation agent. Determination of the sedimentation rate. 9. Preparing and controlling the stability of emulsions. Preparation of the emulsions with simple and complex surface active emulsifiers and evaluation of their stability according to the preparation method, nature and concentration of the emulsifier and the HLB value of the emulsifying agent. Methods of stability control: determination of the duration of the separation of phases, centrifugal behaviour; the particle size of the internal phase, viscosity. 10. Determination of the shelf life of compressed tablets and capsules by applying accelerated ageing test. 2nd SEMESTER 1. Preparation and quality control of ointments (control of homogeneity, particle size, consistency, stretching capacity, structure viscosity). 2. Suppositories- determination of the displacement factor. 3. Preparation of the suppositories by means of moulding and suppositories quality control (aspect, mass uniformity, mechanic resistance, melting behaviour) 4. Milling of powders. Determination of the granulometric distribution (representing histograms and the cumulative frequency curve; determining the average particle diameter). Factors influencing the granulometric distribution (milling device, milling time). 84 2h 2h 2h 3h 3h 6h 3h 3h 6h 6h 3h 6h 3h 3h 3h 3h 6h determining the 6 h influence of blending time and particle size on powder homogeneity by statistical interpretations (D. Obtaining compressed tablets by means of wet granulation and quality control of 6 h compressed tablets (mass uniformity. Lea & Febiger.: The Theory and Practice of Industrial Pharmacy. 2005 6. Philadelphia. 10. Tomuta I. 1995 2.E.: Pharmaceutics-the science of dosage form design. Determination of real density with the pycnometer. Studying the kinetics of 3 h bulk density by tapping and determining the apparent density. Mixing powders.E. Leucuţa S.. References 1.a II-a. Churchill Livingstone.E. 2001. Edinburgh. Presenting the single punch press and rotary press and the phases of the compression process.: Tehnologie farmaceutică industrială. . Editura universitara “Iuliu Hatieganu” Cluj-Napoca. Preda M. the Haussner ratio. Achim M. Presentation of coating equipments. Lieberman H. 2000 7. Powder rheology. filmed 3 h coated tablets) and their quality control (mass uniformity. 6.E.E. ed.: Tehnologia formelor farmaceutice. Universitatea L. Cluj-Napoca. Obtaining solid coated pharmaceutical dosage forms (sugar coated tablets. Procedee de laborator. Strasbourg. 2002 5.L. Leucuţa S. Aulton M. the Carr index. hardness).. the porosity.5. Filling hard gelatine capsules..: Tehnologie farmaceutică industrială. Determining the influence of the mixing system.: Formularea medicamentelor şi a noilor sisteme farmaceutice.: Prepararea medicamentelor.Pasteur.A. 3h 8. Leucuţa S. dissolution) 9.).E. Determination of the angle of repose. 1985 4. Cluj-Napoca. Achim M. dissolution).S. Kanig J. friability. Granule preparation by wet granulation. Leucuţa S.. dissolution time). Following the effect of binding agent concentration on its properties (granulometric distribution... 6h 7. 1973 3. 2008 (in editura) 85 . Lachman L. Capsule quality control (mass uniformity. Editura Universitară “Iuliu Haţieganu” Cluj-Napoca. dissolution. Editura Dacia. Editura Dacia. Leucuţa S. 2. Absorption of dissolved drugs. 11. Fundamental pharmacokinetics. Individualization. Pharmacokinetic interactions. Cmin. biology TEACHING METHODS Lectures with Power Point presentations Practical applications EVALUATION METHODS Written exam with multiple choice questions Practical exam TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 28 hours (14/14) Practical lessons – 56 hours (28/28) BIOPHARMACY AND PHARMACOKINETICS COURSE SYLLABUS 1st SEMESTER 1. Cumulative excretion. Renal failure and pharmacokinetics. Sex. 6. Constant rate infusion. Loading dose.the limiting step of absorption 4. Two-compartment pharmacokinetic model. Factors influencing pharmacokinetic parameters.CHAIR OF PHARMACEUTICAL TECHNOLOGY COURSE TITLE – Biopharmacy and Pharmacokinetics COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire knowledge on the biopharmaceutical properties of drugs and dosage forms and on the pharmacokinetics of drugs in the body: absorption. Variability in pharmacokinetics. Extravascular administration. Cmax. Pharmacokinetic models. Elimination rate constant. Total body clearance. Absorption rate constant. Other models. 7. The pharmacokinetics of multiple intravenous and extravascular doses. 3. Volume of distribution. 4. Kinetics: notions. 9. Biopharmacy and Pharmacokinetics: an introduction. Therapeutic drug monitoring. Pharmacokinetics and age. 2nd SEMESTER 1. loading dose. 8. The concept of pharmacokinetic compartment. Concentration in the steady state. 86 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h 1h . 14. 3. 5. Kinetic processes of the zero and first order. Intravenous administration. physical chemistry. 2. Chemical structure and pharmacokinetic parameters. patient compliance and pharmacokinetic implications. Renal and metabolic clearance. metabolism and excretion phases PREREQUISITE – knowledge of chemistry. Dissolution . dosing interval. 5. 12. 10. The new born and the elderly. Route of administration and bioavailability. The open one compartment pharmacokinetic model. physics. Biological half life. Cardiac insufficiency and pharmacokinetics. Css. The excretion of drugs in urine. Pharmacogenetics. Rate of urinary excretion. chronopharmacokinetics. The pharmacokinetics of the biological response. Clinical pharmacokinetics. distribution. menstrual cycle and pregnancy: influences on pharmacokinetics. 13. 7. Factors influencing the absorption of phenobarbital administered in rats (i.6. 1st order kinetic simulation using sodium salicylate as model drug. spectrophotometric assay. oily). Influence of particle size on absorption (salicylic acid with different but definite granulometery). 6.. 8. Determination of the biological half life in the terminal phase of elimination. particle size (suspensions with particles of different sizes). Synthesis applications and practical applications using data taken from literature. Factors influencing the absorption of phenobarbital administered in rats: influence of adjuvants (polysorbate 80. 12. Accumulation after multiple doses. 14. Equipments. oral. routes).p. 3. Factors influencing the dissolution rate of drugs from compressed tablets: temperature. Pulmonary administration route for medicinal aerosols. Extravascular administration. Systemic transdermic therapy. influence of the urinary pH 87 1h 1h 1h 1h 1h 1h 1h 1h 1h 4h 4h 4h 4h 4h 4h 4h 4h 8h 4h 2h 4h 2h . suspension. Physiological and pharmaceutical factors involved in the bio-availability of drugs. pharmaceutical form (solution. Percutaneous absorption. 11. aqueous. methylcellulose). Rate and amount of absorption. Pharmacokinetics of intravenous continuous infusion. Importance of biopharmacy and pharmacokinetics in the concept of clinical pharmacy PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. Influence of the amount of the lubricant on the release and absorption of salicylic acid from compressed tablets. The large intestine and dosage form administration. Generic drugs and interchangeable dosage forms. Biopharmaceutical factors influencing the release of drugs from pharmaceutical preparations. 13. Influence of ointment base and of salicylic acid incorporation techniques on the in vitro release. Determination of the Cmin and Cmax. 2. Infusion with a bolus. and i. dissolution. Methods. Use of dissolution equipment according to USP 23 and FR X. Bioequivalence. 9. Pharmacokinetics of multiple doses. 5. Topical administration of dosage forms. Drug dosage forms for oral administration. Clearance determination. Ocular and nasal drug administration for systemic therapy. 2nd SEMESTER 1. 4. 10. Calibration curve for salicylic acid. Pharmacokinetics of sodium salicylate from compressed tablets with prolonged release and from compressed tablets with immediate release. pH.m. Description of the “in vitro” experimental pharmacokinetic model used for determining pharmacokinetic constants and dosing regimens of drug administration. Determining bioavailability of drug dosage forms. 7. i. Determination of the rate constant of the absorption process by the method of residuals. medium stirring speed. Determination of the volume of distribution. the Erweka model.c. Loading dose. calcium salt). s. Infusion without bolus. Pharmacokinetics of the single intravenous dose. 3. The stomach and its role in drug absorption. Determination of the elimination rate constant by using blood and urinary data. Colon therapy. Pharmacokinetics of the single extravascular dose.v.. The small intestine and the absorption of drugs. 4. Rectal administration of dosage forms. 6. Measurements of narcotic sleep induced to rat (rate and duration). chemical form of the medicinal substance (acid. sodium salt. Intravenous administration. 5. The esophageal transit. 2. : Farmacocinetica în terapia medicamentoasă. 1975 5. R. Data taken from literature.D.E. Lito U. for 2 h calculating the bioavailability and bioequivalence of drugs.. Editura Dacia.E. Cluj-Napoca. Editura Dacia. Leucuţa S. Lucrări practice. 8. 2002 88 .: Introducere în biofarmacie.Dekker Inc. Leucuţa S. Leucuţa S. Leucuta S.Farmacocinetica. Determination of the bioavailability of some drugs by using the trapezoidal 2 h method. Editura Dacia. 1989. enzymatic induction and inhibition (rats previously treated with phenobarbital for 7 days and another group treated with carbon tetrachloride). dosage regimens. alkalinization with sodium bicarbonate. Bucureşti. Bodea A. Leucuţa S. 7. Notari R.E.E. Cluj-Napoca. References 1.M.: Biopharmaceutics and Pharmacokinetics.. Data taken from our own laboratory research.Pop : Farmacocinetica.(acidulation with ascorbic acid. Using computers for determining pharmacokinetic constants. Cluj-Napoca. intraperitoneal use).: Biofarmacie si Farmacocinetica. New York.E.Cluj-Napoca. 1975 2.M. Editura Medicală..: Biofarmacie .F. 6. 1981 3.E. 1986 4. CHAIR OF TOXICOLOGY COURSE TITLE – Toxicology COURSE AND PRACTICAL LESSONS OBJECTIVES The objective of the course is to provide students basic knowledge of general toxicology. Factors modulating toxicity 3h Chemical factors Biological factors Environmental factors 6. immunology. Dose – effect relationships in toxicology 1h 5. 4. as well as to provide essential knowledge of clinical toxicology and toxicological analysis allowing the clinical and laboratory diagnosis of intoxications and the prevention of toxic effects. Consequences of xenobiotics’ metabolism. organic and analytical chemistry. PREREQUISITE . Phase I reactions. Toxicokinetics 4h Mechanisms of transport across biological membranes Absorption of toxicants Distribution of toxicants Accumulation of toxicants Elimination of toxicants Metabolism of toxicants. physiology. Toxic substances and intoxications 1h Definition and classification of toxic substances Definition and classification of intoxications 3. case studies Practical applications in the laboratory EVALUATION METHODS Written exam Practical exam Evaluation during the semester TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 56 hours (28/28) Practical lessons – 84 hours (42/42) TOXICOLOGY COURSE SYLLABUS 1st SEMESTER GENERAL TOXICOLOGY 1. Phase II reactions. biochemistry. allowing them to understand the fate of toxic substances in the body. their interaction with cell components and the main effects at organ level. pharmacology and medicinal chemistry TEACHING METHODS Lectures with PowerPoint presentations. Introduction in toxicology 1h Definition and aim Historic 2. Mechanisms of toxicity 3h Cellular injuries induced by toxicants Functional effects of toxicants Genetic toxicity Chemical carcinogenesis 89 .knowledge of inorganic. pathophysiology. cadmium. Toxicology of pesticides 90 3h 1h 3h 8h 4h 12 h 8h 2h . mercury. Toxicology of air pollutants Toxicology of carbon monoxide Toxicology of halogens Toxicology of ammonia and nitrogen oxides Toxicology of hydrogen sulphide and sulphur oxides 3. manganese. Toxicology of drugs of abuse Toxicology of opioids Toxicology of cocaine Toxicology of natural hallucinogens Toxicology of designer drugs Toxicology of inhalants Toxicology of substances used in doping Toxicology of nicotine 4. Toxicology of minerals Toxicology of corrosives Toxicology of metals (lead. Target organ toxicity Nervous system toxicity Pulmonary toxicity Hepatotoxicity Nephrotoxicity Toxicology of the blood Dermatotoxicology CLINICAL TOXICOLOGY 1. ethylene glycol Toxicology of cyanides Toxicology of carbon sulphide 2nd SEMESTER CLINICAL TOXICOLOGY 1. anticancer drugs) 3. antibiotics. Toxicology of drugs Toxicology of hypnotic drugs: barbiturates Toxicology of minor tranquilizers (meprobamate. arsenic) 2. benzodiazepines) Toxicology of antipsychotic drugs Toxicology of antidepressant drugs (IMAO. antituberculosis drugs. ethanol. nickel. chrome. Treatment and prevention of intoxications 2. selective inhibitors of serotonin reuptake.Teratogenesis Immunotoxicity 7. tricyclic antidepressants. Toxicology of volatile substances Toxicology of petroleum distillates Toxicology of aromatic hydrocarbons Toxicology of halogenated hydrocarbons Toxicology of nitro and amino aromatic derivatives Toxicology of alcohols and glycols: methanol. lithium) Toxicology of drugs acting on the autonomic nervous system Toxicology of antihistaminic drugs Toxicology of anticonvulsants Toxicology of analgesics-antipyretics Toxicology of cardiovascular drugs Toxicology of chemotherapeutic drugs (sulphonamides. aspirin. Ferejaville J. analysis of illicit powders by TLC) Toxicological analysis of certain pesticides in biological samples (malathion. Editura Medicală Universitară „Iuliu Haţieganu”. 2003 3. nitrogen oxides. sulphur dioxide. Bismuth C. Quantitative analysis of toxicants in air and biological samples 33 h Toxicological analysis of drugs in biological samples (barbiturates.J.... Kiss B. Editura Medicală Universitară „Iuliu Haţieganu”... aniline. Loghin F.. hydrogen sulphide... methanol. Flanagan R. Widdop B. Methods of systematic toxicological analysis 9h Methods of isolation for gases and vapours Methods of isolation for mineral toxicants Methods of isolation for organic toxicants 3. Popa D. Anton R. phenothiazines. Wolff F.. Dally S. ed. Organisation Mondiale de la Sante. Analize şi evaluări toxicologice. formaldehyde. Braithwaite R. Identification of toxicants by chromatographic methods 3h 6. F. Brown S. tricyclic antidepressants. Paris. Identification of toxicants by chemical methods 3h 5. Toxicological evaluation of drugs 6h Assessment of acute toxicity: determination of medium lethal dose Testing of mutagenicity by micronucleus test 4. ethylene glycol.. phases 3h 2. 2000 91 . Popa D. ClujNapoca.5). Loghin.. Editura Medicală Universitară „Iuliu Haţieganu”.Toxicology of insecticides Toxicology of fungicides Toxicology of rodenticides Toxicology of herbicides 5. Applications of toxicological analysis in the diagnostic of certain cases of 3 h intoxications References 1. Toxicological analysis: classification.. 1997 5. cholinesterase activity in blood) 2.A.. chloride) and of biomarkers (carboxyhemoglobin) Toxicological analysis of volatile substances (ethanol. izoniazide. Conso F. hippuric acid. 2002 2.. DNOC) Quantification of biomarkers of pesticide intoxication (total p-nitro-phenol in urine. Kiss B. Quantitative analysis of toxicants in air and biological samples 18 h Toxicological analysis of gases (carbon monoxide. Cluj-Napoca. Toxins 2h Mycotoxins Poisonous mushrooms PRACTICAL LESSONS 1st SEMESTER 1. Baud F. 2005 6. Toxicologie clinique (ed. phenol.. Geneve. Medécine Science Flammarion. Analyses et evaluations toxicologiques. 2.Botta A... acetaminophen) Toxicological analysis of certain drugs (total morphine in urine. paraquat. sulphate index) 2nd SEMESTER 1.. methemoglobin. Loghin F.. Toxicologie.. Edition TEC & DOC Lavoisier. 2004 4. Toxicologie generală.A. Elements de toxicologie analytique. cyanide) Quantification of certain biomarkers of intoxications with volatiles (paminophenol.S. Analysis of clinical cases of intoxications 6h 3. thiocyanate. benzodiazepines. Paris. Cluj-Napoca. Viala A. Biological drugs used in immunoprophylaxis – The immune system – Therapy with immunoglobulins Polyclonal antibodies Homologous sera: human immunoglobulins .knowledge of immunology. anticoagulant therapy. phage display technology 2. fibrinolytics Biological drugs interfering in the haematopoiesis 3. PREREQUISITE . Practical works have as objective to familiarise the students with the analytical techniques used on biological matrices and also with the methodology of calculation and interpretation of the results. microbiology. Biological drugs.normal and specific Heterologous sera Monoclonal antibodies – Vaccino-prophylaxis National Vaccination Plan (vaccination schedule) Obligatory vaccines 92 4h 6h 14 h . EVALUATION METHODS Written exam (multiple choice questions) at the end of each term Practical exam (evaluation of theoretical and practical skills) at the end of the term TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 28 hours (0/28) Practical lessons – 14 hours (0/14) BIOLOGICAL DRUGS AND BIOLOGICAL DRUG CONTROL COURSE SYLLABUS 1. pharmaceutical technology TEACHING METHODS Plenary lectures assisted by multimedia support. or by genetic engineering. Hemotherapy – General information Physical and chemical properties of blood Blood collection and securisation Blood fractioning – Labile blood derivatives – Stable blood derivatives – Biological drugs interfering in the coagulation cascade: coagulation factors. physiology. The blood and blood derivatives. which contains the necessary information for the performing of each activity. Obtention methods – Extractive methods – Genetic engineering Recombinant DNA technology Transgenic animal.CHAIR OF DRUG ANALYSIS COURSE TITLE – Biological drugs and biological drug control COURSE AND PRACTICAL LESSONS OBJECTIVES To provide students informations regarding biological drugs obtained either by traditional techniques of extraction (from animal bodies). pathology. 1. The students carry out practical works and introduce the results in the personal book (in a bulletin). Vaccines: Expert Consult. http://www. February 2008. www. 5. 1998 10. Brumboiu MI. 2003 3. Blood and Blood Transfusion. Quantitative analysis of penicillin’s conditioned in pharmaceutical forms 2h 4. http://www. 2002 8. Shander A. Immunisation against infectious disease . Desai MA. Walsh G.sante. Nezlin R. 2006. Bocşan IS. Perioperative Transfusion Medicine. Medicală Universitară “Iuliu Haţieganu”. Ed. 2008 11. http://www. Ed.cdc. http://www.pdf 6. 2005 12. Vaccinuri şi Vaccinări în practica medicală. 9.europa. Decker Inc. Nomenclator.eu 17. Downstream Processing of Proteins.who.ro 16. BMJ Publishing Group. Humana Press Inc.uk/greenbook 14.gov/vaccines/ 15. Humana Press Inc. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 2nd edition.dh. http://www. Quantitative analysis of the pepsin conditioned in pharmaceutical forms 2h References 1. Direction générale de la santé.emea.the Green Book. Marder VJ. Offit PA. Pharmaceutical Biotechnology. Spiess BD. 5th edition. Quantitative analysis of pancreatin conditioned in pharmaceutical forms 2h 3. Isolation and Purification of Proteins. Ed. Biological drugs obtained by extraction from animal organs and/or 4 h biotechnology – Enzymes with therapeutic value – Hypophyseal hormones obtained by biotechnologies – Biological drugs obtained from the intestinal membrane – Biological drugs obtained from the pancreas – Biological drugs obtained from the liver PRACTICAL LESSON SYLLABUS 1. ANM. Lippincott Williams & Wilkins. Spence RK. George JN. ***. Lippincott Williams & Wilkins.pdf 13.. Orenstein WA. Hatti-Kaul R. Marcel Dekker. 2007 18. Concepts and Applications.gov. 2003 4. Ed. 2000 2. PDQ Hematology. Guide des vaccinations 2006. Ed. Biological methods for quantitative analysis : 4h – Microbiological quantitative determination of antibacterial drugs – Radio Immuno Assay (RIA) – Enzyme-Linked ImmunoSorbent Assay (ELISA) 2. Methods and Protocols. Centers for Disease Control and Prevention. Cutler P. 5th edition. John Wiley & Sons Ltd. Mattiasson B. Martindale 35: The Complete Drug Reference. Ed. The Immunoglobulins: Structure and Function.. European Medicines Agency. World Health Organization. CD-ROM edition 2007 93 . Colman RW. Ed. Clowes AW. Galley HF. The Clinical Use of Blood Handbook 2001. Protein Purification Protocols. Methods in Molecular Biology. Recommended vaccines Vaccines for travellers 4.. 2nd edition. Saunders..inpes. Kern W. Comité technique des vaccinations.anm.fr/CFESBases/catalogue/pdf/927. 2002 7. Goldhaber SZ. 2006. Ed. Plotkin SA. Quantitative analysis of streptomycin conditioned in pharmaceutical forms 2h 5. Academic Pr.int/bloodsafety/clinical_use/en/Handbook_EN. Ed. The Pharmaceutical Press. H2 antihistaminic drugs 9. Cholinomimetic drugs 5. Pharmacology of local anesthetics 14. Pharmacology of opioid analgesics 13. Pharmacology of anti-migraine drugs 2nd SEMESTER 1. Cardiovascular pharmacology. PREREQUISITE – knowledge of anatomy. Pharmacology of general anesthetics 15. Ganglioplegics. needed for the understanding of the pharmacology of the main classes of drugs Practical lessons: the study of experimental models used for the evaluation of the pharmacokinetics and pharmacology of drugs. Neurotonic drugs 21. pathology. Pharmacology of anticonvulsive drugs 17. Beta-blockers 4. Cholinergic pharmacology. Autonomic pharmacology. Pharmacology of steroidal anti-inflammatory drugs 10. Adrenergic pharmacology. physiopathology. Antihypertensive drugs 94 3h 1h 3h 2h 2h 2h 2h 1h 2h 3h 1h 2h 2h 2h 3h 2h 2h 2h 1h 1h 2h 1h 2h 1h 3h . Cardiovascular pharmacology. Cholinergic pharmacology. Cardiotonic drugs 2. Pharmacology of NSAID's 11. Antiarrhytmic drugs 3. Nicotinic pharmacology. Pharmacology of histamine. Alpha-blockers 3. PHYSIOLOGY AND PHYSIOPATHOLOGY COURSE TITLE – Pharmacology COURSE AND PRACTICAL LESSONS OBJECTIVES Course: Acquiring knowledge of general pharmacology. Central and peripheral muscle relaxants 7. physiology. Pharmacology of sedatives-hypnotics-tranquilizers 16. H1 antihistaminic drugs 8. Pharmacology of antidepressant drugs 18. Autonomic pharmacology. Adrenergic pharmacology. Autonomic pharmacology. Pharmacology of antiparkinsonian drugs 20.CHAIR OF PHARMACOLOGY. Adrenergic pharmacology. Pharmacology of analgesics-antipyretics 12. Anticholinergic drugs 6. Cardiovascular pharmacology. Adrenomimetics 2. Autonomic pharmacology. Pharmacology of anti-Alzheimer drugs 22. biochemistry TEACHING METHODS Interactive lectures Experiments on laboratory animals and computer alternative methods EVALUATION METHODS Written exam Practical exam TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 84 hours (42/42) Practical lessons – 70 hours (28/42) PHARMACOLOGY COURSE SYLLABUS 1st SEMESTER 1. Autonomic pharmacology. Pharmacology of CNS stimulants. Pharmacology of antipsychotic drugs 19. Pharmacology of the blood. The thyroid medication 1h 17. Pharmacology of adrenergic system 2h 2. 2. antiparasitary and antiviral drugs 3h 20. Editura Medicală Bucureşti 2005. The endocrine medication. Digestive system pharmacology 3h 5.4.5 h 14. Pharmacology of CNS stimulants 2h 2nd SEMESTER 1. Respiratory pharmacology. 2h Spasmolytic drugs 13. Editura 95 . Pharmacology of antitumoral drugs 2h PRACTICAL LESSONS SYLLABUS 1st SEMESTER 1. Aurelia Cristea. Pharmacology of NSAID's 2h 7. Anticoagulant drugs. Antidiarrheic drugs. Renal pharmacology 3h 4. Pharmacology of metabolic disease. Metabolic pharmacology 3h 7. Ediţia a VII-a. 1998. Diuretic drugs 2h Cardiovascular pharmacology. Bazele farmacologice ale practicii medicale. Antianginal drugs. Antihypotensives 2h Cardiovascular pharmacology. antiemetic drugs. 5. Endocrine system pharmacology 3h 8. Antianemic drugs 1h 9. Cough-suppressive agents. Pharmacology oh H1 antihistaminic drugs. Cardiovascular pharmacology 9h 2. Respiratory system pharmacology 3h 6. Pharmacology of digestive system. Venoactive drugs 1h Pharmacology of the blood. Aurelia Cristea. Nicotinomimetic drugs 2h 6. Pharmacology of anticonvulsive drugs 2h 11. Pharmacology of antitumoral drugs 3h References 1. Didactică şi Pedagogică Bucureşti. Emetics. 3. Hemostatic drugs 8. Pharmacology of antiparkinsonian drugs 2h 13. Farmacologie generală. Pharmacology of local and general anesthetics 2h 9. Pharmacology of antimycotic. Antiulcerous drugs 2h 11.5 h 18. gastric and 1h pancreatic secretion replacements 12. Pharmacology of the peripheral muscle relaxants. Expectorants. Tratat de Farmacologie. Pharmacology of antidepressant drugs 2h 14. Pharmacology of tranquilizers-sedatives-hypnotics 2h 10. Gout pharmacology 1h 16. 7. antiparasitary and antiviral drugs 3h 10. Pharmacology of antibiotic and chimiotherapic drugs 6h 9. Valentin Stroescu. Pharmacology of metabolic disease. Pharmacology of the blood 6h 3. Peripheral vasodilators. Antiplatelet drugs. Pharmacology of antimycotic. Cardiovascular pharmacology. 3h Antiasthmatic drugs 10. Pharmacology of digestive system. Hypolipemic drugs 1. Pharmacology of analgesic drugs 2h 8. The endocrine medication. Pharmacology of cholinergic system 2h 4. Pharmacology of adrenergic system 2h 3. Pharmacology of digestive system. Pharmacology of antibiotic and chimiotherapic drugs 6h 19. Laxatives-purgatives. The sexual hormones 2. Pharmacology of metabolic disease. 6. 3h Fibrinolytics. Pharmacology of cholinergic system 2h 5. Antidiabetic drugs 2h 15. Ed. Pharmacology of antipsychotic drugs 2h 12. Mogoşan Cristina. 96 . 10. The pharmacological basis of therapeutics.. 2003. 2007. Pharmacology. 2005. Editura Medicală Universitară „Iuliu Haţieganu” Cluj-Napoca 2005. Ed. Landry Y. 5. Cohen Y. Dunod. Pharmacologie. 2006. 6. Ed. New York 2007. Pharmacologie.. Paris. Bazele experimentale ale farmacologiei... Rang H.. Ritter J.Medicală. 7... 2001. des cibles vers l’indication therapeutique.M. Schorderet M.P. Basic and Clinical Pharmacology. Pharmacologie. Frison-Roche. Des concepts fondamentaux aux applications therapeutiques. Editura Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca. Ed.G. Goodman&Gilman’s. Editia a 10-a. Dale M. Gies J-P. 4.M. Slatkine Geneve 1992. Abrégé de PHARMACOLOGIE. Ed. Editura McGraw-Hill. Mc Graw Hill. Masson. 9. 11. Katzung B. 8.. Mogoşan Cristina. Ghibu Steliana. Voştinaru Oliviu. 2001.. Jacquot C. Ed. Churchill Livingstone. Practical approach. Statistical evaluation of experimental data. 6h 3. PREREQUISITE – knowledge of pharmaceutical terminology. Formulating a research problem 2. Statistical tests (t student. review). Marcel Dekker Inc. Conceptualisation of a research design 3. Recommendations 4h 4. To realize and perform a presentation. The research process: 5h 1. Processing data 8. 1999. Marcel Dekker. D. Writing a scientific paper (article. collecting and processing data. Writing a research proposal 6. Recommendations 1h TUTORIAL CLASS SYLLABUS 1. scientific report). Practical approach. New York. Bolton S. 2. Radius Press. Bibliographic documentation on the internet. Inc. D.Pharmaceutical Statistics: Practical and Clinical Applications. De Muth – Basic Statistics and Pharmaceutical Statistical Applications. Editura Dacia.CHAIR OF DRUG ANALYSIS COURSE TITLE – Research methodology COURSE AND PRACTICAL LESSONS OBJECTIVES Course: studying and understanding of the research process. Also. Collecting data 7. EVALUATION METHODS Multiple choice questions (MCQ) test at the end of semester (50% of the final score). informatics. 2. Selecting a sample 5.K – Multivariate Statistical Analysis. 4. Constructing an instrument for data collection 4. Kachigan S. databases and journals 10 h References 1. New York. 1991. Modalities to perform a scientific presentation. During the tutorial class. Basic statistics and pharmaceutical statistical applications. 89-90. Wilcoxon) 2. 6h 4. statistics TEACHING METHODS Plenary lectures assisted by multimedia support Tutorial class: Lecture assisted by power point presentation. Writing a research report. 1997 444-489. 2007 97 .L Dumitraşcu – Introducere în cercetarea ştiinţifică.. New York. Modalities to write a scientific paper (article. followed by individual practice. 4h 3.. they are trained to recognise a valid source for bibliographic documentation and to realise an appropriate presentation of the results. students are trained to perform statistical evaluation on the experimental data and interpretation of the results. witting a research proposal. Evaluation of practical abilities and theoretical knowledge: questions and computer applications (50% of the final score) TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (14/0) Practical lessons – 28 hours (28/0) RESEARCH METHODOLOGY COURSE SYLLABUS 1. 3. 6 h ANOVA. James E. second edition. writing a research report.Dumitraşcu. 1996 7. Mary Helen Briscoe – Preparing Scientific Illustrations. Research Methodology. 1999. London. 1999 6. Andrei Achimaş Cadariu – Metodologia Cercetării ştiinţifice. 1997 8. 98 . Springer.5. Sauramps Editions. Editura Medicală Universitară “Iuliu Haţieganu”. Roger Benichoux – Guide de communication medicale et scientifique. Cluj-Napoca. a step-by-step guide for beginners. Kumar R. Sage Publications. second edition. Editura Medicală Universitară "I. 2004. Biochemistry of Redox Reactions. 99 . 2005. Haţieganu". 5. pharmacology. Harcourt Brace and Company Publishers. Corina Ionescu. Haţieganu" Cluj-Napoca. An Imprint of Chapman & Hall. Skett P. 1999. PREREQUISITE – knowledge of organic chemistry. London : Blackie Academic & Professional. 1995. The Netherlands. Dordrecht. Cluj-Napoca. Enzymatical systems involved and molecular mechanisms of biotransformation. 2. Pharmacological and toxicological consequences of drugs biotransformation. New York : Marcel Dekker. reductions. 2h 4. Editura Medicală Universitară "I. London : Academic Press. Biotransformarea medicamentelor. TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (14/0) DRUG METABOLISM COURSE SYLLABUS 1. 6. Woolf TF. Corina Ionescu.. toxicology TEACHING METHODS Interactive course based on video projection Power Point (animated) presentations EVALUATION METHODS Discussions during the course and final oral examination. Testa B. Metabolic pathways of biotransformation: phase I (oxidations. pharmaceutical chemistry. Current concepts in Drug Metabolism. Springer. 2h 5. biochemistry.. 3. 3. with the purpose of optimising the therapeutic act by increasing the efficacy and lowering the risk of adverse reactions and interactions. 2h 6. complex process with impact on both main and secondary actions of drugs. Factors that influence drugs biotransformation. and 2 h hydrolysis processes) and phase II reactions (conjugations). The pharmacogenetics and pharmacogenomic concepts. We want to underlie the importance of understanding the phenomena at molecular level. editors. Inc.CHAIR OF PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE TITLE – Drug metabolism COURSE OBJECTIVES The aim of the present course is to offer basic informations concerning drugs biotransformation. The Metabolism of Drugs and Other Xenobiotics. Well J. Gordon GG. 4. Oniga O. Molecular aspects of the preliminary processes of drugs biotransformation: 1 h membrane crossing and binding to plasma proteins. 7. Testa B. Reacţii adverse şi interacţiuni medicamentoase. Induction and inhibition of drug-metabolising enzymatic systems. 2001.. Introduction to Drug Metabolism. Mino R. Handbook of Drug Metabolism. Consecutive 2 h drugs interactions. Corina Ionescu. Caira. 1h References 1.. 1997. 2. Photosensitising plants 1h 8. Considerations upon the toxic plants of the Romanian flora 1h 11. Londrs. New Cork. Legislation of toxic plants in Romania and all over the world References 1. Poisonous ornamental plants 1h 4. Medicală Universitară "Iuliu Hatieganu". Daniela Hanganu. Toxicity of aromatic plants 1h 9. Edition TEC& DOC. Vegetaux dangereux pour l′homme et les animaux. Recommended conduct in intoxications 1h 13. Cluj-Napoca. Plants causing dermatitis 1h 5. Paris. Popescu – Plante toxice – Ed. Plants containing toxalbumins 1h 6. 2002 2. H. Bruneton – Plantes toxiques. J.CHAIR OF PHARMACOGNOSY AND PHYTOTHERAPY COURSE TITLE – Toxic plants COURSE OBJECTIVES Acquiring information regarding medicinal plants with toxicological and allergenic potential from botanical and toxicological point of view PREREQUISITE – knowledge of botany and pharmacognosy TEACHING METHODS Lectures with Power Point presentations EVALUATION METHODS Written Exam TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (14/0) TOXIC PLANTS COURSE SYLLABUS 1h 1. Plants causing allergies 1h 7. Alimentary risks 1h 10. Plants in judicial toxicology 1h 12. Hallucinogens of vegetal origin 1h 14. 1996 100 . Cultivated toxic plants 1h 3. Toxic plants of the wild flora 1h 2. Drug-food interactions. 2003 4. Nutritional recommendations. Cervera R. Ed. Nutrition and hypertension. D. Nutritional recommendations. Second edition. Nutrition and renal disorders. 3. . 1h 5. Nutrition in adolescence. Rigolfas R. 1996 101 . 2. 1998 6. Alimentary balance and dietetics – treatment per se or complement in various 1 h pathologies.5 h 13. Nutrition and dyslipidemia. Enteral and parenteral nutrition support. but also regarding the diet conduct required by a health individual in order to prevent nutritional unbalances.Nutritie si dietoterapie. Clapes J. Nutrition in the adult age. Nutrition for weight management.5 h 14. pathology TEACHING METHODS Lectures with Power Point presentations EVALUATION METHODS Written exam Bibliographic research on a given subject TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (14/0) NUTRITION AND DIETOTHERAPY COURSE SYLABUS : 1. Ed. – Essentials of human nutrition. Basdevant A. Nutrition & Diet Therapy. 1 h biliary disorders. Mc. ESF editeur. Food allergies and intolerance. Nutrition and obesity. 1h 15. Nutritional recommendations. et col.5 h 9. Lerebours E. Sendrea. Laville M. Paris. Elsevier (USA). ed. Nutritional recommendations. 2004. Nutritional recommendations. 1h 12.5 h 6. Dietetic products. Mann J. 2. Nutrition and diabetes. Oxford University Press. Printek Cluj-Napoca. Mahan LK. 0. Nutritional recommendations 10. New born 2 h and small child nutrition. Escot-Stump S – Krause2s Food. Pharmaceutical implications. An aim is also to provide future pharmacists an adequate tool to competently advise the patients regarding the diet therapy elements as a complement of prescribed drug treatment. Medical nutrition therapy for Cancer prevention. Flammarion Medecine-Sciences (France) 2001 3. Nutrition in childhood. – Alimentacion y dietoterapia. Nutritional recommendations. pancreatic. Dupin H. / Traite de nutrition clinique de l’adulte. Stewart Truswell A. 4. 1h 7.Alimentation et Nutrition Humaines. Nutrition and cardiovascular disease. PREREQUISITE – knowledge of environmental chemistry and hygiene. 0. Nutrition during life cycle. Nutrition and hepatic. Nutrition and gastrointestinal tract disorders. Nutrition in aging. 1h 11. treatment and recovery. 1h References 1. Medical nutrition therapy for anemia. 3a Edicion. 0. 1h 8. Nutrition during pregnancy and lactation.CHAIR OF ENVIRONMENTAL CHEMISTRY AND HYGIENE COURSE TITLE – Nutrition and dietotherapy COURSE OBJECTIVES To acquire knowledge on nutrition and the healthy human body necessities during its life cycle. Ed. Nutritional 1 h recommendations. 0. 1992 5. Graw-Hill Interamericana. 3.CHAIR OF MEDICAL DEVICES COURSE TITLE – Summer practice for the 4th year students in pharmacy PRACTICE OBJECTIVES Acquiring knowledge on other work places where pharmacists can be employed: pharmaceutical industry. toxicology. methods of work. Knowledge of principles. monitoring and verification of practice tutors pharmacist Explanations. and drug warehouses. X. 1993 2. Nomenclatorul de medicamente şi produse medicamentoase de uz uman. Editura Medicală. 2008 102 . laboratories (biochemistry. pharmaceutical technology. Frequency 2. Bucureşti. Farmacopeea română. analytical chemistry. Knowing the specific of practice's place. informatics. analysis of how to solve real professional problems EVALUATION METHODS Characterization of student’s work by the coordinating pharmacist regarding: 1. 2. The application of theoretical knowledge in pharmacy practice. Involvement in the pharmacy activity 4. PREREQUISITE – knowledge of biochemistry. environmental chemistry. and environmental chemistry). Compliance with the internal rules of organization and conduct of work. under the coordination. 2008 3. Memomed. toxicology. Knowledge of pharmaceutical legislation. Ed. medicinal chemistry. Bucureşti. Bucureşti. 3. References 1. Editura Minesan. 2008 4. Filling the practice notebook Oral exam TEACHING LANGUAGE Romanian language French or English language for foreign students that perform the practice in their own country NUMBER OF HOURS 120 hours: 4 weeks – 30 hours / week SUMMER PRACTICE FOR THE 4TH YEAR STUDENTS IN PHARMACY SYLLABUS 1. acquiring some practical skills and commenting results. Bucureşti. Agenda medicală. Agenţia Naţională a Medicamentului. discussions. Editura Medicală. The attitude towards the staff of the pharmaceutical unit. General notions 2 h The subject of the discipline drug industry and pharmaceutical biotechnologies The development of drug industry in the world and in our country General notions of chemical technology of drugs Industrial devices for the drug synthesis 2. applications Human recombinant insulin Recombinant human growth hormone and recombinant somatostatin 103 . PREREQUISITE – knowledge of organic chemistry. genetics TEACHING METHODS Lectures Practical applications in the laboratory.. presentations on given subjects EVALUATION METHODS Written exam (multiple choice questions) Practical exam TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 42 hours (42/0) DRUG INDUSTRY AND PHARMACEUTICAL BIOTECHNOLOGY COURSE SYLLABUS 1. Applications of biotechnology in pharmaceutical industry 16 h General notions Biosynthesis technological processes First and second generation biotechnology Antibiotics Vitamins Organic acids Proteins Steroids Third generation biotechnology DNA recombinant technology: steps.CHAIR OF DRUG INDUSTRY AND PHARMACEUTICAL BIOTECHNOLOGY COURSE TITLE – Drug industry and pharmaceutical biotechnology COURSE AND PRACTICAL LESSONS OBJECTIVES Acquiring theoretical knowledge regarding industrial preparation of pharmaceutical substances via chemical synthesis and biotechnology Applying theoretical knowledge to the synthesis of pharmaceutical substances using industrial methods. The main chemical processes with their applications in drug synthesis and 10 h examples Oxidation Reduction Halogenation Nitration Condensation Transposition 3.. Baze teoretice şi aplicaţii”. Cluj Napoca.. X. 1994. Australia. 2001. 1987. acylation. Synthesis of some drugs and some intermediate substances in the lab.A. Mitrea Vasilescu Niculina. C. 2003.. Cristea I. Dăescu. Bota Cristina. Coman Mioara. 1991. Crommelin D. Bucureşti. Bota Cristina – „Farmacobiotehnologie”. 13. Bota Cristina. C. 2000. hydrolysis References 1. 1984. reduction. Proinov L. Timişoara. 2000. Litografia Universităţii din Cluj-Napoca. 1998. Editura Tehnică.„Elemente de Biotehnologie”. Timişoara. Rakosy Tican L. Editura Medicală Universitară „Iuliu Haţieganu”. Bucureşti.J. 10. 2. Litografia I. 12. – „Industria medicamentelor”. . Tipografia Mirton. condensation. The organization of a drug factory 2. Jugrestan F. C. Editura Tehnică. 5. Viesturs U. Litografia Institutului Politehnic. – „Chimia şi tehnologia medicamentelor”. Partea I. 6. Jurcoane Ştefana – „Fundamente. vol. 2000. A. Sindelar R. Bucureşti. Dăescu C. Coman Mioara. 1988. 11. 1982. based on 39 h reactions of: oxidation.D.F. Cluj Napoca. 104 . Editura Medicală Bucureşti. A. . . Ceres. Bucureşti. Pop Carmen – „Industria medicamentului.A. Viesturs I. Biorectoare.V. Cluj Napoca. nitration. – „Reacţii şi mecanisme de reacţie în chimia organică”. Coman Mioara.. 3. 9. . Recombinant interferons Rt-PA Interleukins Recombinant vaccines PRACTICAL LESSONS SYLLABUS 3h 1. Oniscu. Editura Didactică şi Pedagogică. Harwood Academic Publishers. – „Biotehnologii utilizate în prepararea medicamentelor”. . Andrieş A. Editura Srima.şi semisinteză”.M. 1997. I. Zilevica (traducere din limba rusă):„Biotehnologie”. Enzime”. Srima. izonitrosation. Cluj Napoca.. Facultatea de Tehnologie Chimică. Soran V. 15... 1993. Enoiu M. Work protection in the drug factories. 14. Editura Uni-Press. 2004. Ed. – „Chimia şi tehnologia medicamentelor”.„Tehnologia produselor farmaceutice”. Cluj-Napoca. Dăescu. Pop Carmen – „Biotehnologii farmaceutice”. Ed. Ardelean A.„Produse de bio. Lupuleasa D. 8.„Pharmaceutical Biotechnology”. Editura Risporint. Bucureşti.„Curs de industria medicamentului”. 4. 7. Medicines with special legal status: drugs. The supply of the medicines in the social security system. The prescribing and the supply of the medicines in pharmacy. in order to be able to interpret them and to apply them in practice. 6. Computer application. the role of the pharmaceutical societies. The pharmaceutical inspection: the surveillance and the control of pharmaceutical societies. Computer application. pharmaceutical societies. The creation of a pharmacy: the file and the building organization. The national system of social policy: principles. 5. 7. The activity of preparing in pharmacy: magisterial and officinal medicines. the pharmaceutical ethics. The administration of the pharmacy and pharmacy records. doping products. responsibility. Computer application. The objectives of the course of Pharmaceutical legislation are to study and to understand the legal injunctions concerning the pharmacist profession and the activities regarding pharmaceuticals. The arrangement and the storage of medicines. Pharmaceutical legislation: objectives. The national system of health care: public health care. importance for the pharmacist’s activity. drugs precursors. 3. PRACTICAL LESSONS SYLLABUS 1. The profession of pharmacy: conditions for practice. The provisioning of the pharmacy. Computer application. Computer application 105 2h 4h 4h 6h 6h 4h 2h 2h 2h 4h 2h 4h 2h 4h 2h . 8. 2. 3. Computer application. The medicine: definition. 5. 4. public health authorities. Computer application. The checking of medicines’ delivery. Application: documents and the pharmacy plan. 6. PREREQUISITE – knowledge of all speciality disciplines in the curriculum of the 3rd and 4th year of pharmacy curriculum TEACHING METHODS Lectures with Power Point presentations Practical lessons: computer applications EVALUATION METHODS Written exam: multiple choice questions Practical lesson: questions and computer applications TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 28 hours (28/0) Practical lessons – 28 hours (28/0) PHARMACEUTICAL LEGISLATION COURSE SYLLABUS 1. public authorities. the representative body of practitioners. the correct use of professional documents and the software for pharmaceutical administration. activities.CHAIR OF PHARMACEUTICAL LEGISLATION COURSE TITLE – Pharmaceutical legislation COURSE AND PRACTICAL LESSONS OBJECTIVES To acquire adequate knowledge of the legal framework for practicing pharmacy. 2. The objectives of the practical lessons are to learn and to understand the correct organization and practice of the pharmacy activities. structure. 4. 7. Cluj Napoca. Droit pénal des produits de santé. 2002. 2002. Editura Medicală Universitară “Iuliu Haţieganu”.. ediţia anuală. 2007.. Pharmacy Law and Ethics. Computer 2h application. 2002. Arcane Institut. Paris. Paris. Cluj-Napoca. Application: documents. création et gestion d’une pharmacie. The Pharmaceutical Press.. 10. 3. Recapitulation of pharmacy activities.. 7. Pharmaceutical legislation in force. 6. the inventory in pharmacy. 2.9. Boboia A. Litec. 106 .. 2h 11. 2h References 1.. Fouassier É. 4. Benaiche L. Masson. Polinicencu C.. The work security in pharmacy. The control of the administration... Wingfield J. Activitatea din farmacie – Ghid pentru lucrări practice de legislaţie farmaceutică. London 1997.E. Appelbe G. Marché. La responsabilité juridique du pharmacien. Crişan O. Editura Medicală Universitară “Iuliu Haţieganu”. 5. Profesiunea de farmacist – probleme de legislaţie. Godefroy M. Crişan O.-L. They calculate and interpret of the results and fill in the analysis certificate. 11. Infrared spectroscopy. Practical training offers the skills needed to perform a complete quality control check of a pharmaceutical dosage form. tablets and capsules. Applications for pharmaceuticals 14. Romanian National Agency of Drugs – regulatory body of pharmaceuticals quality control. Basic calculation in pharmaceutical analysis. 6. organic chemistry. Thermal analysis – TGA. PREREQUISITE – knowledge of physical chemistry. inorganic chemistry.CHAIR OF DRUG ANALYSIS COURSE TITLE – Drug analysis COURSE AND PRACTICAL LESSONS OBJECTIVES Studying and understanding the official regulations and analytical methodology in pharmaceutical field. Qualitative and quantitative analysis of syrups. Applications for pharmaceuticals 13. Applications for pharmaceuticals 9. 5. DSC. pharmaceutical technology TEACHING METHODS Plenary lectures assisted by multimedia support Practical lessons: The students apply analytical methods to quantify drugs in all types of pharmaceutical dosage forms. Standard operating procedures for the assay (SOP). Qualitative and quantitative analysis of solutions. High performance capillary electrophoresis. Physical and chemical properties of drug molecules. Method validation – definitions and methodology. analytical chemistry. 4. Stereochemistry of drugs. filling the quality certificate and results interpretation. Applications for pharmaceuticals PRACTICAL LESSONS SYLLABUS 1. applied for quality assurance of pharmaceutical dosage forms. Ultraviolet and visible spectroscopy. HPLC. GC. Extraction method in pharmaceutical analysis. Applications for pharmaceuticals. Applications for pharmaceuticals. 2. Qualitative and quantitative analysis of suspensions and emulsions. Fluorescence spectroscopy. Control of errors in analysis. Drug stability 7. Applications 6. Qualitative and quantitative analysis of ointments. 5. Qualitative and quantitative analysis of powders. Qualitative and quantitative analysis of suppositories. 2. 3. Polarimetry. 4. EVALUATION METHODS Multiple choice questions (MCQ) test at the end of semester. (50% of the final score) Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical activities and written test) at the end of semester (50% of the final score) TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –42 hours (42/0) Practical lessons – 42 hours (42/0) DRUG ANALYSIS COURSE SYLLABUS 1. 8. 12. Applications for pharmaceuticals 10. 107 2h 2h 2h 2h 1h 5h 1h 9h 5h 1h 1h 9h 1h 2h 9h 3h 6h 6h 6h 12 h . Good laboratory practice (GLP). Mass spectrometry. Chromatographic methods – TLC. Titrimetric and chemical analysis method. 3. 1992 4.III. Deva. J. 2005. Bidlingmeyer . 1990 13. a X-a. Medicala.Farmacopeea Romana ed. second edition. 2007. R.L. *** .C. a X-a. Supliment 2004. 7.USP XXV. A. Oprean -Analiza si controlul medicamentelor. J. Muntean – Validarea Metodelor analitice.Farmacopeea Europeana.. *** .Farmacopeea Romana ed.Farmacopeea Romana ed. Hamon.2006. Oprean . 10. M. a VI-a. Watson – Pharmaceutical Analysis. Masson. Ed. Medicala. Elsevier.Farmacopeea Romana ed. Sandulescu. Roman. 14.References 1. Săndulescu. Pradeau . B. Boylan . *** . Editura Medicală. 2007 12. 5.Chimie analitique. Bojiţă. M.2000. *** . 1988 108 . a X-a. Ed.Farmacopeea Romana ed. 1993 6. Roman. A textbook for pharmacy students and pharmaceutical chemists. Ed.2001. Ed. D. Volumul 1 Bazele teoretice si practice. Ed. M. 9.Encyclopedia of Pharmaceutical Technology. L. M. Medicala. M. vol. F. Bucureşti. R. Roman.Analiza si controlul medicamentelor. Bojită. Supliment 2001. a X-a. Pellerin. R. Volumul 2 Metode instrumentale in analiza si controlul medicamentelor. Bojiţă. *** . Sandulescu. Mahuzier . D. Ed. Swarbrick. Medicala.Practical HPLC methodology and applications. L. *** . Intelcredo.L'analyse practique du medicament. 2007 11. David G. R. G. Ed. ed. 2 edition. Supliment 2000. Ed. John Wiley and Sons Inc..2004. Paris. Intelcredo. Medicala. a X-a. 2002 2. 1992 15. R. Guermet. Supliment 2006. Deva. Medicales Internationales. Marcel Dekker Inc. *** . 2003 3. 8. L. pathophysiology. 9. Pharmacist’s involvement in patient care. biopharmacy. semiology. clinical biochemistry TEACHING METHODS Lectures with Power Point presentations Clinical cases analyses Problems solving EVALUATION METHODS Written examination – Multiple choice questions Practical/oral examination – Clinical case resolution TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –28 hours (28/0) Practical lessons – 42 hours (42/0) CLINICAL PHARMACY . Pharmacotherapy principles. pregnancy.CHAIR OF CLINICAL PHARMACY COURSE TITLE – Clinical pharmacy . Risk factors for medication nonadherence. diagnostic consideration). 3. 7. 109 4h 2h 2h 2h 2h 2h 2h 2h 2h . To integrate knowledge about disease and medicine and to apply them with the aim to optimize patient’s pharmacotherapy. Methods to improve adherence. Pharmacotherapy principles. Hypertension pharmacotherapy Introduction (etiology. Drug therapy optimization. Pharmacotherapy in particularly cases: children. elderly. Pharmacotherapy principles. Introduction Definitions.Pharmacotherapy COURSE AND PRACTICAL LESSONS OBJECTIVES To understand the principles of clinical pharmacy practice. asthma) 5. Patient adherence to therapy Defining adherence. Ischemic heart disease pharmacotherapy Introduction. adverse drug reactions managing). Drug therapy optimization (strategies.PHARMACOTHERAPY COURSE SYLLABUS 1. 2. Pharmacotherapy principles. Adherence to long term therapy (hypertension. Asthma pharmacotherapy Introduction. 8. Heart failure pharmacotherapy Introduction. Dyslipidemias pharmacotherapy Introduction. renal failure 4. PREREQUISITE – knowledge of pharmacology. Outcomes of clinical pharmacist interventions in hospital and community pharmacy. drug interactions. Clinical pharmacy practice development. Pharmacotherapy principles. epidemiology. Pharmacist’s involvement in patient care. Drug therapy optimization. Drug therapy optimization. diabetes mellitus. Drug therapy optimization. Pharmacist’s involvement in patient care. Pharmacist’s involvement in patient care. Risk reduction Clinical pharmacist role in reduction of the impact of adverse drug reactions and drug interactions. 6. Editura Stiintelor Medicale 6. 2005 3. Liver disease pharmacotherapy 2h Introduction. 10. 8th ed.Applied Therapeutics: The clinical use of drugs. 1990 110 . 11. Pharmacist’s involvement in patient care. Clinical activities (pediatrics hospital) 9h References 1. 6th ed. Patient –centred case studies with the aim to optimize patient’s drug therapy.Pharmacist’s involvement in patient care. Pharmacist’s involvement in patient care. Stratégies et communications.A. Peptic ulcer disease pharmacotherapy 2h Introduction. L . patient specific information assessment. Lippincott Williams&Wilkins. Pharmacotherapy principles. ESCP – Pharmacie clinique. McGraw-Hill. Masson. Clinical use of antimicrobials. Pharmacist’s involvement in patient care. 2003 4. 13. Diabetes mellitus pharmacotherapy 2h Introduction. care plan development. a pathophysiologic approach. drug therapy problems identification. Pharmacotherapy principles. Pharmacist’s involvement in patient care. 3e ed. 2. Young L. Pharmacotherapy principles. 12. Fauci et al – Harrison. A 33 h rational decision making process is used: drug therapy analysis. Principii de medicină internă. Gimenez F et al – Pharmacie clinique et therapeutique. Drug therapy optimization. including interventions designed to resolve or prevent drug therapy problems. Principles of antimicrobial use 2h Elements of pharmacology. Drug therapy optimization. Editions Médicales Internationales. 2005 2. Walker R. Koda-Kimble M. 2008 5. Dipiro J T et al – Pharmacotherapy. 3d ed. Edwards C – Clinical Pharmacie and Therapeutics. Churchill Livingstone. ed 15. Drug therapy optimization. PRACTICAL LESSONS SYLLABUS 1. 7. Hair removal cosmetics: formulation. Exfoliating cosmetics. 12. creams.CHAIR OF DERMOPHARMACY COURSE TITLE – Dermopharmacy and cosmetology COURSE AND PRACTICAL LESSONS OBJECTIVES Study of the most frequently occurring skin diseases and the study of the preparations used for their prophylaxis and treatment. Ectoparasite skin infections. 15. 111 2h 2h 2h 2h 2h 3h 1h 2h 1h 2h 1h 1h 2h 1h 2h 2h . 10. anatomy. formulation. Oral health products. pigmentation troubles. Oral pathology. melanin types. 3. 16. about type of cosmetic products. histology and physiology of skin. 8. Pharmaceutical dosage forms for topical use. Principles of treatment in topical medication. Hair care cosmetics. Hair loosing cosmetics. Bacterial. chemistry. Skin care for men: shaving cosmetics. 5. 4. physiology. Introduction. treatment. characterization and evaluation of cosmetic products. Primary and secondary skin lesion. manifestations. their composition and formulation. patient counselling). acne (causes. Antiperspirants and deodorants. emulsions. treatment. patient counselling). Plaque psoriasis (causes. 13. biochemistry. Terminology. learning about preparation. Hand and nail care cosmetics. methods. Composition. tolerance. treatment. 11. Theoretical and practical study of preparation and utilization of cosmetics: learning about skin care essentials. PREREQUISITE – knowledge of botany. Cosmetic care for each skin condition. fungal and viral skin infections. Skin cleansing cosmetics – soaps. 2. Pigmentation: mechanism. patient counselling). legislation of cosmetics. Photoprotection: natural and artificial protection. Skin aging and anti-aging cosmetics. pharmaceutical technology TEACHING METHODS Lectures with Power Point presentations Practical applications in the lab EVALUATION METHODS Written examination: multiple choice questions and/or questions with a short answer (70% of the final score) Practical examination: managing a specific situation presented during the practical activities and/or questions with a short answer (30% of the final score) TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –28 hours (28/0) Practical lessons – 28 hours (28/0) DERMOPHARMACY AND COSMETOLOGY COURSE SYLLABUS 1. physics. lesions. 14. 9. Pathology of sebaceous gland: seborrheic dermatitis (causes. Skin care cosmetics: skin hydration and hydrating cosmetics. lotions. Anatomy. 6. Cosmetology: Different skin types and their characteristics. Skin type classification.C.med. Cluj-Napoca. Oil/water emulsions and creams. Cluj-Napoca. Farmacopeea Română Ed. 2h References 1. vol. 499p. Preparation and characterization of water/oil 3h disperse systems. creams. In vitro 2h determination of solar protection factor from suntan cosmetics. Paris. http://dermatlas. 2001. a V-a 8. Influence of soap type on hydration. – Dermatofarmacie şi Cosmetologie. Moldovan M. Mitsui T. 2h 11. mouth rinse. Paris. skin pH and skin barrier 3h function. Preparation and characterization of oil/water 3h disperse systems. Choosing cleansing cosmetics for different skin type. – Introduction à la dermopharmacie et à la cosmétologie. Determination of skin phototype. Dermopreparations for protection. Preparation and evaluation of shampoo.. Casa Cărţii de Ştiinţă.Flammarion. Aplicaţii practice. 10. 3. Farmacopeea Europeană ed. Amsterdam. 6. Dermopreparations for protection. a X-a. Médicine-Sciences. 9. 1998 6. – Patologie Cutanată.PRACTICAL ACTIVITIES 1. Bucureşti. Cleansing cosmetics. 8. Face scrubs. Martini M. Dubertret L. Evaluation of scrub effect on skin appearance. Cosmetic masks: preparation and characterization 2h 4.– Thérapeutique Dermatologique.edu/derm/ 112 . 2000 5. Skin care products counselling. Counselling about sun protection cosmetics. lotions. 1h 5. 7.Medicală Universitară „Iuliu Haţieganu”. Ed. Editura Medicală. Make-up removers. 4. – New Cosmetic Science. III. Ed. 3. Lavoisier Tec & Doc. 2006. Acneic and seborrheic skin care: personal hygiene products. 2007. 2. 2. Preparation and characterization of make-up removers and 2h toner. 3h Therapeutic strategy for acne patient. Ed. Presentation of some clinical cases. Oral care products: toothpaste. Water/oil emulsions and creams. 1993 7. Ed. Maier N. Sunscreens and suntan products: preparation and characterization. Ed. Recognition of skin type 3h and product counselling according to the skin type. 2h 12. Elsevier. Evaluation of hydrating and protective effect.jhmi. Evaluation of hydrating effect. pharmaceutical technology TEACHING METHODS Lectures with Power Point presentations Practical applications in the lab EVALUATION METHODS Written examination with multiple choice questions and/or questions with a short answer (60% of the final score) Practical examination: managing a specific situation presented during the practical activities and/or questions with a short answer (40% of the final score) TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –14 hours (14/0) Practical lessons – 14 hours (14/0) TECHNOLOGY OF HOMEOPATHIC REMEDIES AND OF VETERINARY DRUGS COURSE SYLLABUS TECHNOLOGY OF HOMEOPATHIC MEDICINES 1. Homeopathic prescription. 2. Most common veterinary pathologies: internal and external parasites. digestive pathology. Preparation of mother tinctures from vegetal materials: methods and control. Preparation of mother tinctures from chemical source: methods. 1h 6. mineral remedies). 1h VETERINARY DRUGS 1. 1h 3. 1h 5. chemistry. Boundaries and 1 h indications of homeopathy. PREREQUISITE – knowledge of botany. Models for explaining the action of homeopathic doses. anatomy. 1h 2. biochemistry. 1h 8. 1h 4. 1h 6. Preparation of homoeopathic and veterinary drugs. Homeopathic diathesis. Veterinary pharmaceutical dosage forms. Homeopathic definitions. Homeopathy and the human terrain. 1h 4. 1h 7. 1h 4. physiology. 1h 5. legislation. Pathogenesis of the medicines. Veterinary pharmacy: definition. 1h 9. physics. 1h 7. Homeopathic pharmaceutical dosage forms. 1h 3. Preparation of inert homeopathic granules and globules. Preparation of liquid homeopathic dilutions. 1h 113 . Nature of homeopathic remedies (vegetal.CHAIR OF DERMOPHARMACY COURSE TITLE– Technology of homeopathic remedies and of veterinary drugs COURSE AND PRACTICAL LESSONS OBJECTIVES The aim of this course is to describe the basic of homeopathy and veterinary pharmacy. Preparation of homeopathic medicines. 1h 3. Good manufacturing practice for homeopathic laboratory. Routes of veterinary drug administration. Impregnation of liquid dilution on the inert supports. 1h 5. Dispensing veterinary drugs. animal. Doses of veterinary drugs. skin 1 h pathology. Preparation of solid homeopathic dilutions. Homeopathic principles. 1h 2. PRACTICAL LESSONS SYLLABUS 1. Homeopathic therapy. Counselling the patient who takes homeopathic medicines. 1h 11. 1h 10. Payre-Ficot A. Homeopathic medicines frequently used in homeopathy. Editura Medicală Universitară „Iuliu Haţieganu”. France. – Homéopathie. Cluj-Napoca. 1990 7. 1h 9. Study of the pathogenesis of a homeopathic medicine. Desachy F. 1996 4. Kayne – Homoeopathic Pharmacy. Le conseil au quotidien.Conseil vétérinaire à l'officine pour les animaux de compagnie.. Ed. Churchill Livingstone. Cluj-Napoca.8. 2007 6. 1981 5.Notions essentielles de Matière Médicale Homéopathique. J. a V-a 114 .Jouanny . Lyon.. 1997 3. Moldovan M. 4h References 1. PRO-OFFICINA. Boiron. Ed. Boiron M. Ed. Ed. Visit at the industrial laboratory of homeopathic medicines. . Suciu – Forme farmaceutice de uz veterinar. 2ème édition. G. – Compendiu de homeopatie. S. Boiron. Ed. 2007 2. Farmacopeea Europeană ed. Dacia. The managerial process: planning. 15. 10. so that the pharmacist is able to practice as a manager in the pharmaceutical field. synthesis themes. 5. the policy of the product. 2002.knowledge of all speciality disciplines in the curriculum of the 3rd and 4th year of pharmacy curriculum TEACHING METHODS Lectures with Power Point presentations Case study Discussions on given subjects EVALUATION METHODS Writing examination: MCQ. The managerial communication. The pharmaceutical market: purveyors. Le management – Voyage au centre des organisations. 9. social responsibility and ethics of the activity of marketing. functions and objectives of marketing. The pharmaceutical management and the manager: definition. knowledge. Arcane Institut. Mintzberg H. 7. 13. The management of the marketing: strategies of marketing. their use and application in the field of the medicine. control and assessment of the activities. 2. evaluation. 2. 14. The marketing environment. 12. consumers. structure. References 1. The behaviour of habitual and organizational consumer. taking decisions. 3. Marché.CHAIR OF PHARMACEUTICAL LEGISLATION COURSE TITLE – Management and marketing COURSE OBJECTIVES The aim of the course is that students acquire adequate knowledge of pharmaceutical management and marketing. 4. the policy of the price. methods and techniques of management. 11. working style. 8. PREREQUISITE . stimulating people. the business plan and the marketing plan. The concept of marketing: definition of marketing and of pharmaceutical marketing. The management of the personnel. création et gestion d’une pharmacie. specific features. independent themes TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –28 hours (28/0) MANAGEMENT AND MARKETING COURSE SYLLABUS 1. segments. The mix of marketing: concept and general notions.. the problems of pharmaceutical management. The objectives of the course of Marketing are the understanding of the general notions of marketing. The objectives of the course of Management are the study and understanding of the notions of management. the policy of the distribution. the specificity of the pharmaceutical field. The structure and the process of building a business. 115 2h 2h 2h 2h 2h 2h 2h 2h 1h 2h 2h 2h 1h 2h 2h Éditions . The methods for market study. the policy of the promotion. The manager: necessary qualities. Systems. 6. The market: general notions. for the profitableness of the pharmaceutical societies. 9. Teora. Voitcu M. Théorie et pratique de l’économie de la santé.. Bucurescu S. ESKA. 1999. 116 . Ed. I et II. Marketing pharmaceutique. Cuparencu B. Ed. Harboun Ch.. Kotler P. Marketing pentru industria farmaceutică..-M. Giornalidea. Iaşi.. Paris. Ponoran V. Paris. Cărăuşu E.. 1998. 10.. Paris. Technique et Documentation – Lavoisier. Bucureşti. Gr. Zambrowski J. Ed.. vol.. Popa. Bucureşti...d’Organisation. 5. Dacia. Ed. Farmacia & Marketing. Giampietri R. 2004. Marketingul medicamentelor. 1998.J. 7.. Wong Veronica. Kotler P. 2002 . Principiile marketingului. Ribierre D. Armstrong G. Saunders J. 11. Paris. Chatain R. Cluj-Napoca. Ed. 1992. 8. Comment manager son équipe. 6. 4. Masson. Managementul marketingului. 1997. Paris. 2001. Teora.. Ed.. Le marketing pharmaceutique. Masson. 1986. T.. 1995.T. 3. CHAIR OF CLINICAL PHARMACY COURSE TITLE – Pharmaceutical actualities TYPE OF COURSE – Integrative course COURSE OBJECTIVES To present updates on sexual hormones dysfunctions and their consequences: menopause. Phytotherapy 6. Pharmacology of drugs used in postmenopausal hormone replacement therapy. osteoporosis. in osteoporosis and erectile dysfunction 4. in osteoporosis and erectile dysfunction 3.knowledge of all speciality disciplines in the curriculum of the 3rd and 4th year of pharmacy curriculum TEACHING METHODS Lectures with Power Point presentations EVALUATION METHODS Written exam with multiple choice questions TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –14 hours (0/14) PHARMACEUTICAL ACTUALITIES COURSE SYLLABUS 1. Nutritional therapy 7. Pharmaceutical dosage forms containing sex hormones 8. and erectile dysfunction PREREQUISITE . Pharmacotherapy 5. Toxicology of sex hormones 3h 2h 2h 3h 1h 1h 1h 1h 117 . Chemical structure-biological activity relationship of drugs used in postmenopausal hormone replacement therapy. Elements of physiopathology 2. Activities and responsibilities in the patient care process 2. to identify. Drug therapy problems identification. and resources needed to practice. Ethical considerations in Pharmaceutical care practice 8. Pharmacotherapy assessment: appropriateness of the indication. Knowledge. Pharmaceutical care practice implementation. The pharmacist’s role. Documenting the information and interventions. The pharmacotherapy workup. 2. effectiveness.CHAIR OF CLINICAL PHARMACY COURSE TITLE – Pharmaceutical care COURSE OBJECTIVES To familiarize the students with Pharmaceutical care philosophy To increase knowledge on drugs with application to patient care To develop skills needs. safety. The use of treatment algorithms. Clinical and economical impact of pharmaceutical care practice 3. Pharmaceutical care evolution.Pharmacotherapy TEACHING METHODS Lectures with Power Point presentations Clinical cases analyses Discussions Role playing EVALUATION METHODS Written exam Practical/oral examination – Presentation of Pharmaceutical care patient chart for one patient to whom the student provided pharmaceutical care TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course –14 hours (0/14) Practical lessons – 28 hours (0/28) PHARMACEUTICAL CARE COURSE SYLLABUS 1. patient compliance. solve and prevent actual or potential drug-related problems PREREQUISITE . Drug therapy problems: categories. The practitioner’s responsibilities. Assessment of drug related needs 5. The patient’s rights and responsibilities. Self-care and non-prescription pharmacotherapy. The patient involvement in decision-making process. causes 6. Evaluation of effectiveness and safety of drug therapy. Barriers to implementation of Pharmaceutical care practice PRACTICAL LESSONS SYLLABUS 1. practical exercises (role plays). Collection of patient specific information concerning clinical condition and drugs used. The therapeutic relationship defined. skills. the pharmaceutical care patient chart 7. attitude. Pharmaceutical care definition. The standards for professional behaviour 4. Examples of situations which may require additional information or physician referral Situations when the pharmacist must select self-treatment and advise the 118 1h 1h 2h 1h 2h 4h 1h 2h 1h 9h . The formulation of care plan. Introduction. Development of care plan to resolve or prevent drug therapy problems. The assessment of the patient’s condition. The pharmacist – patient relationship. Nickless G. Hagel HP. 2004 2. Morley PC. Strand LM. Green C. A practical guide to Pharmaceutical care. 2006 4. rheumatic disorders . 2nd Edition. Prescription analysis. The clinician’s guide. 4 h cardiovascular disorders. McGraw-Hill. American Pharmaceutical Association.patient for specific conditions 3. respiratory disorders. 2 nd Edition. skin disorders 4. Tietze KJ. Mosby. 2003 3. Prescriptions examples for specific diseases: infections. Clinical skills for pharmacists. Pharmaceutical Press. 1997 119 . McDonough RP. Currie JD. Rovers JP. Sobotca JL. Pharmaceutical care practice. Pharmaceutical care made easy. A patient-focused approach. Cipolle RJ. Providing of pharmaceutical care patient chart 4h References 1. Communication skills of the pharmacist 6h 5. gastrointestinal disorders. neurological and psychological disorders. Sexton J. organisation. Paris. mechanism. Aspects of pharmacovigilance in using drugs in paediatrics 3h References 1. Ed. General aspects on pharmacovigilance: objectives. the place of 3 h pharmacovigilance in drug research. Aspects of pharmacovigilance in the use of oral contraceptives 1h 4. immunology TEACHING METHODS Course with Power Point presentations EVALUATION METHODS Written exam TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (0/14) PHARMACOVIGILANCE COURSE SYLLABUS 1. The management of adverse drug reactions: From diagnosis to signal.R. monitoring PREREQUISITE – knowledge of pharmacology. Guide pratique de la farmacovigilance. 2001. 3 h monitoring. prevention. Pradel. pathology. 727-733 120 . Benichou C. prevention. Reacţii adverse şi interacţiuni medicamentoase. Therapie. 2-eme edition. 56. the role of the reglementation agencies 2. UMF Iuliu Haţieganu Cluj Napoca.. View over the adverse reactions: classification. 2004 2. validation 3.. Oniga. O.CHAIR OF PHARMACEUTICAL CHEMISTRY COURSE TITLE – Pharmacovigilance COURSE OBJECTIVES To acquire knowledge on the importance of the activity of pharmacovigilance in monitoring the adverse reactions of drugs and on the methods used for adverse reactions’ identification and reporting To improving the knowledge on the adverse reactions: mechanism. 1996 3. Ed. Edwards I. Aspects of pharmacovigilance in pregnancy 2h 5. Corina Ionescu. The objectives of the course are to exercise and to reflect to the aptitudes necessary for the management of pharmacy business.CHAIR OF PHARMACEUTICAL LEGISLATION COURSE TITLE – Pharmacy as business COURSE OBJECTIVES The aim of the course is that students acquire adequate knowledge of the pharmacist’ role in the management of the pharmacy business. GlaxoSmithKline. manager. Junior Achievement România. profit. GlaxoSmithKline. Junior Achievement România. The role of the relationship pharmacist – patient in the business: 4 hours communication. 4 hours 4. Farmacia – mod de administrare. employee. sale. 3 hours 2. PREREQUISITE – knowledge of legislation. 3 hours 3. The pharmacy in the market economy. 2. The business – efficiency. 121 . by the identification of patients’ needs and by satisfying these needs by offering quality services and products. ediţia anuală. Bucureşti. marketing. EVALUATION METHODS Written examination: MCQ Individual and group work Final projects in work group TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (0/14) PHARMACY AS BUSINESS COURSE SYLLABUS 1. Farmacia – mod de administrare. The pharmacist – owner. marketing. Manualul studentului. development. Junior Achievement România. in order to make it profitable. Bucureşti. The pharmacist’ role. Manualul trainerului. management TEACHING METHODS Lectures with Power Point presentations Exercises and case study evaluated in working groups. References 1. ediţia anuală. Junior Achievement România. Relations between functions. 6. 2006 2h 2h 2h 2h 2h 2h 2h Cartii de 122 . Lombosciatic. Pneumothorax 2. Polyneurophaties 7. 5. Pain in the limbs. Digestive emergencies. editura Casa Stiinta. Metabolic emergencies. Acute intoxications Bibliographie 1. Hypoglycaemic coma. Acute abdominal pain. 4. Cardiovascular emergencies. Renal failure. Kidney and urinary emergencies.CHAIR OF SEMIOLOGY AND INTERNAL MEDICINE – IV MEDICAL CLINIC COURSE TITLE – Medical emergencies COURSE OBJECTIVES To acquire knowledge regarding the firs-aid measures to be given in a pharmacy PREREQUISITE – knowledge of pathology. Respiratory emergencies: Acute respiratory failure. physiology. lipothymia. Cardiogenic choc. Acute arterial embolia. pathophysiology TEACHING METHODS Lectures with interactive presentations EVALUATION METHODS Written exam (multiple choice questions) TEACHING LANGUAGE Romanian language NUMBER OF HOURS Course – 14 hours (0/14) MEDICAL EMERGENCIES COURSE SYLLABUS 1. Hypertension crisis. Negrean Vasile. 3. Acute asthma attack. Syncope. Acute lung oedema. Hyperglycaemic coma. Intestinal-mesenteric infarct. Urgente medico-chirurgicale pentru farmacisti. Nephritic colic. clinical pharmacy. under the coordination. quantitative and value reception of drugs Documents elaboration: reception note. registration of products with special status Ensuring the conditions of conservation 2) Analysis of pharmaceutical substances Identification reactions Fact sheets analysis of pharmaceutical substances Ensuring the conditions of conservation 3) Preparation of medicines and officinal formulas Technical elaboration of the formulation Packaging. monitoring and verification of practice guiding pharmacist To acquire knowledge and practice regarding the role. conservation Documents elaboration: registration of medicines and officinal formulas 4) Dispensing drugs Dispensing prescription drugs Documents elaboration for CAS: summaries.CHAIR OF MEDICAL DEVICES COURSE TITLE – In service training TRAINING OBJECTIVES To acquire knowledge regarding the organization of the activity in a pharmacy (community of hospital pharmacy) To participate effectively in all specific activities of the profession. medical devices. responsibility and obligations of the pharmacy profession PREREQUISITE – knowledge of pharmaceutical legislation and organization. 26 weeks IN SERVICE TRAINING CONTENTS 1) The reception of drugs The qualitative. pharmacology. under the coordination. discussions. labelling. toxicology. invoices Prescription processing computer program Dispensing OTC medicines 123 . analysis of how to solve professional problems encountered Practicing communication techniques with the patient EVALUATION METHODS Characterization of student’s work by the coordinating pharmacist regarding the: Frequency Compliance with the internal rules of organization and conduct of work Involvement in the pharmacy activity The attitude towards the staff of the pharmaceutical unit Filling the practice notebook Oral exam (interview) with the examination commission (teachers at the Faculty of Pharmacy and instructors pharmacists nominated by the College of Pharmacists Cluj-Napoca) TEACHING LANGUAGE Romanian language NUMBER OF HOURS 35 hours/ week. pharmaceutical technology. medicinal chemistry. cosmetology. etc. TEACHING METHODS The application of theoretical knowledge acquired during faculty in pharmacy practice. monitoring and verification of practice guiding pharmacist Explanations. reeditare în ediţie revizuită 2008 2. inventory lists 7) Resolving the problems from the Practice Guide 8) Integration into the pharmacy activity References 1. Editura Minesan. Bucureşti. Farmacopeea română. 1993 3. Supplementary bibliography recommended during the 5 year curriculum 124 . Agenţia Naţională a Medicamentului. Editura Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca 2005. Bucureşti. Memomed. Ed. Bucureşti. 2008 4.Dispensing homeopathic medicines Dispensing phytotherapeutic medicines Dispensing biological medicines Counselling / health education of patients 5) Dispensing other pharmaceutical products Dispensing food supplements Dispensing cosmetic products Dispensing medical devices 6) Filling other documents used in pharmacy: cashbook. Editura Medicală. daily management report. X. Agenda medicală. Editura Medicală. Ghid de practică pentru studenţii anului V. 2008 6. 2008 5. Bucureşti. Nomenclatorul de medicamente şi produse medicamentoase de uz uman. (ISBN 973-693-092-0).