Therapeutic and Toxic Blood Levels

Winek's Drug & ChemicalBlood-Level Data 2001 Prepared by: Charles L. Winek, Ph.D., Wagdy W. Wahba, Ph.D., Charles L. Winek, Jr., B.S. (Pharm.), M.S., and Tracey Winek Balzer B.S. (Pharm.), M.S. We have gathered the data in the table from the literature and from personal experience. The values are not considered absolute, but are to be used as a guide in evaluating a given case. The values can be affected by dose, route of administration, absorption differences, age and sex, tolerance, method of analysis, pathological or disease state, postmortem redistribution, etc. Users of the table are referred to Winek's Toxicology Annual and Chapter 72 in Forensic Medicine, Volume III, by Tedeschi, Eckert and Tedeschi for chapters discussing the data, reference to the data, and factors affecting blood-level values. For additional pharmacokinetic information and other tissue levels, users are referred to Baselt’s reference, Disposition of Toxic Drugs and Chemicals in Man. Users are cautioned against pharmacists using pharmacokinetics for interpretation of blood-level data when death is involved. It should be obvious that kinetics, even pharmacokinetics, are not applicable to the moribund state. Units Drugs and chemicals in the table are reported in both mg% and µg/mL. Drugs are listed by both their trade and generic names. Mg% (milligram percent) is equal to mg/dL (milligram/deciliter); µg/mL (microgram/milliliter) is equal to mg/L (milligram/liter). NOTE: Divide the mg% level by 100 to obtain mg/mL Divide the µg% level by 100 to obtain µg/mL. To convert mg/L or µg/L to mg% or µg%, divide level by 10. Examples: 1mg/L = 0.1mg% 3µg/L = 0.3µg% µg is the representation for microgram (mcg). Many therapeutic drugs are reported in nanograms/ milliliter (ng/mL). To convert the listed mcg/mL in this table to ng/mL, multiply the listed value by 1000. For example, digoxin concentration of 0.0022 mcg/mL would be 0.0022 x 1000 = 2.2 ng/mL. Put simply, you move the decimal point three places to the right. Definition of Blood Levels Therapeutic Blood Level Winek defines a therapeutic blood level as that concentration of drug and/or its active metabolite(s) present in the blood (serum or plasma) following therapeutically effective dosage in humans. Toxic Blood Level The concentration of drug and/or its active metabolite(s) or chemical present in the blood (serum or plasma) that is associated with serious toxic symptoms in humans. Lethal Blood Level The concentration of drug and/or its active metabolite(s) or chemical present in the blood (serum or plasma) that has been reported to cause death, or is so far above reported therapeutic or toxic concentrations, that one can judge that it might cause death in humans. Normal Blood Level Some of the values under normal represent normal body constituents and others represent values related to normal environmental exposure. Values can, and do, vary with geographical location. Suggested additions or corrections can be made by contacting the author at [email protected]. Recommendations are always welcomed. Dr. Charles L. Winek Dr. Winek is a professor of toxicology at Duquesne University School of Pharmacy and also teaches for the University's School of Education, Graduate School of Arts and Sciences, and the Law School. He is a diplomate of both American Board of Forensic Toxicology and the Academy of Toxicological Sciences. Dr. Winek is currently the director of Pittsburgh Criminalistics Laboratory and is the former chief toxicologist for the Allegheny County Coroner's Office, positions he held for 32 years. He continues to testify frequently as an expert witness in both criminal and civil cases in Allegheny County and throughout the United States. Dr. Winek has published 119 articles in scientific journals and authored, co-authored or contributed to 29 books. Additionally, Dr. Winek is toxicology editor for the scientific journal Forensic Science International and a member of the editorial boards of The Journal of Applied Toxicology and the journal Analytical Toxicology. (NOTE: Winek's Drug & Chemical Blood-Level Data 2000 is reprinted with written permission as a courtesy to our customers. Fisher HealthCare accepts no responsibility for the accuracy of its contents.) 00035 0.025 0.0.2.0004 .1 .0.0.10 .39 Aluminum 0.0.09 .0.9.25 >0.010 .0.25 0.12 31 .5 0.039 0.0 .58 370 .002 .5 15 Aldrin 0.1.3 Alprazolam (Xanax) 0.20 Page 1 .044 ***** ***** ***** ***** Actifed (Pseudoephedrine) 0.20 3-4 30 .0 2.5 1-5 1-3 10 .087 .3 .0.0.0.0.02 .0004 .021 0.0.2.0029 .04 0.0.5 .12 0.0.017 .20 Amitriptyline (Elavil) 0.1.6 13 .7 ***** ***** ***** ***** [+met: Nortriptyline] Ammonia Amobarbital (Amytal) 0.0.015 .2 .0.0.15 Asendin (Amoxapine) 0.0 2.5 1-5 1-3 10 .1.021 0.077 0.2.10 .0. Procardia) 0.077 0.13 ***** ***** ***** ***** Amantadine (Symmetrel) 0.5 .70 0.025 .004 .1.2 .9 .013 0.2.96 Anafranil (Clomipramine) 0.029 .044 ***** ***** ***** ***** 0.9.15 5 .25 >0.0.02 .0.0.33 3.5 >0.5 10 .05 .12 0.1 1 0.045 0.21 .1 .0015 0.0.0.2 ***** ***** ***** ***** Alfentanil (Alfenta) 0.Drug and Chemical Blood Level Data .5 .40 5 .15 ***** ***** ***** ***** Acetohexamide ( Dymelor) 2.30 200 .0.87 .5 0.1.250 ***** ***** ***** ***** Salicylate-for analgesic use] Acetylsalicylic Acid [as met: Salicylate-for rheumatoid arthritis] Actidil (Triprolidine) 0.0.0.002 .295 .3 .8 Ambien (Zolpidem) 0.0102 0.21 ***** ***** 0.0044 0.56 ***** ***** ***** ***** Acetone ***** ***** 20 .0015 .22 ***** ***** ***** ***** Antabuse (Disulfiram) 0.2.0.10 20 .0 Aniline ***** ***** ***** ***** 0.99 Arsenic 0.250 Amitriptyline (Elavil) 0.31 0.210 ***** ***** ***** ***** Alphaprodine (Nisentil) 0.05 >0.30 1.0.5 .01 .12 .012 .02 .112 0.050 .003 .038 .5.05 .12 Aminophylline (Theophylline) 1-2 10 .12 0.05 <0.122 .0.0.40 ***** ***** 0.1 .1.0.00015 0.0.0.300 50 500 2 .77 ***** ***** 1.3 .12 .017 .1 >1 Amytal (Amobarbital) 0.20 Amoxapine (Asendin) 0.062 0.0.06 .3 Ansaid (Flubiprofen) 1 .7.5 ***** ***** 0.25 20 .63 6.0.48 2.004 .102 ***** ***** 0.4.0.30 150 .0.006 .0.20 15 150 >16 >160 Acetazolamide (Diamox) 1.0.040 0.295 .1 .0.50 .011 0.0062 0.021 0.0.0.9.38 .1 .05 1 .30 1.1.012 .0.0.77 Acetylsalicylic Acid [as met: 2 .5 ***** ***** ***** ***** Adalat (Nifedipine.120 40 400 ***** ***** Analeridine (Leritine) <0.9 3 .11 >0.010 .0272 0.300 55 550 Acetonitrile [met: to Cyanide] ***** ***** ***** ***** 0.0122 .6 13 .6 21 .1.9 .1 .0035 ***** ***** Alfenta (Alfentanil) 0.0025 .9 19 (Triprolidine) Actron (Ketoprofen) 0.00 ***** ***** 0.5 .0044 0.0.2001 Therapeutic or Normal DRUG mg% Toxic ug/ml mg% Lethal ug/ml mg% ug/ml A Acebutolol (Spectral) 0.18 .25 50 .0.5 ***** ***** 0.5 9 .025 0.018 .95 .0.0.0017 .95 .2.0017 .17 0.2 ***** ***** ***** ***** Acetaminophen (Tylenol) 1-2 10 .162 ***** ***** ***** ***** Alcaine (Proparacaine) ***** ***** ***** ***** 1.05 >0.1 .272 ***** ***** 0.1.0.4 ***** ***** ***** ***** [+met: 8-OH-amoxapine] Amphetamine 0.0.0.03 .100 0.2 ***** ***** ***** ***** Allegra (Fexofenadine) 0.031 0.5 ***** ***** 37 .2 10 .5 5-25 ***** ***** 11 110 Aralen (Chloroquine) 0.45 ***** ***** ***** ***** Anaprox (Naproxen) 3.21 ***** ***** 0.96 Amoxapine (Asendin) 0.100 15 .0 2 .580 Antipyrine 0.05 >0.0162 0.05 . 0.035 .0.0147 0.0.159 1.0.5 35 ***** ***** [+met: 8-OH-amoxapine] Ativan (Lorazepam) 0.200 ***** ***** ***** ***** Bentyl (Dicyclomine) 0.025 .3.1 .5 1-5 1-3 10 .0.08 0.1.50 ***** ***** ***** ***** Bismuth 0.01 ***** ***** 0.0.0.04 .9 4.2.69 7.Drug and Chemical Blood Level Data .0.0.6 .8 ***** ***** ***** ***** [met: Amitriptyline (Elavil)] AZT (Retrovir.11 ***** ***** ***** ***** Bupropion (Wellbutrin) 0.1.0004 Atarax (Hydroxyzine.0.0.1.014 .126 0.008 0.0.0200 0.04 .8 >8 Benemid (Probenecid) 10 .0 16 .0.05 0.02 .0088 .1 1 0.002 .2 122 ***** ***** ***** ***** Atropine 0.147 ***** ***** 0.11 .02 .7 .9 ***** ***** >3 >30 Page 2 .0025 .3 Buspar (Buspirone) 0.40 4-6 40 .0.40 1.30 .17 .08 0.0.200 ***** ***** 0.0.0.0.001 .2 Benzphetamine (Didrex) 0.5 .0500 0.0375 0.6 0.70 3.4 ***** ***** ***** ***** Aventyl (Nortriptyline) 0.375 0.3 .0008 .0088 .0.1 .73 7.050 0.6 ***** ***** Atromid (Clofibrate) 12. Fiorinal) 0.0.002 .02 .0.004 0.022 .22 .500 >0.6 .16.7 Bethanid (Bethanidine) 0.0.0.44 4.0.002 . Zidovadine) B Baclofen (Lioresal) 0.0 1285 .024 0.245.0.2.39 Atenolol (Tenorim) 0.5 ***** ***** Barbital 1 .05 .0.1 .100 ***** ***** 0.0.3 Butabarbital (Butisol) 0.60 >8 >80 Barbiturates (short acting) 0.76 .3 13 0.03 .006 ***** ***** 0.20 .008 .45 1 10 ***** ***** Buprenex (Buprenorphine) 0.2 .0.002 .23 ***** ***** ***** ***** Boron 0.1.11 ***** ***** ***** ***** Buprenorphine (Buprenex) 0.6 .088 .0126 0.02 .6 10 .025 .0.0.023 0.20 100 .027 .35 1.90 .0014 .4 ***** Astemizole (Hismanal) 0.0.69 7.50 ***** ***** ***** ***** Bethanidine (Bethanid) 0.048 0.9 ***** ***** >3 >30 Butalbital (Sandoptal.0.76 .011 0.008 .2001 Therapeutic or Normal DRUG Asendin (Amoxapine) mg% Toxic ug/ml mg% ***** Lethal ug/ml ***** mg% ***** ug/ml 0.0100 0.11 .0.5 .2 .0.014 .002 .0.26 Butanediol ***** ***** ***** ***** 28 280 Butaperazine (Repoise) 0.0.0.0.3.02 .23 3 .1250 128.1.26 6-8 60 .15.0022 .27 .0048 0.04 0.02 0.06 0.7 7 1 10 Benadryl (Diphenhydramine) 0.05 >0.0002 .2450 Bropheniramine (Dimetane) 0.5 1.04 Brevibloc (Esmolol) 0.6 13 .008 0.0025 .069 0.050 0.0.008 0.3 2-3 Benzene ***** ***** >0 >0 0.16.1.12 0.6 0.8 4 40 5 50 Brethine (Terbutaline) 0.4 7 .02 .0.5 1. Fioricet.0112 0.0147 0.69 ***** ***** ***** ***** Butazolidin (Phenylbutazone) 1.00004 0.0.24 0.0.090 .0.0.08 ***** ***** 0.0.112 0.02 .01 .005 .3 .0.004 .08 .0.0.001 0.4 14 Benztropine (Cogentin) 0.0.06 0.45 .7 .30 >3 >30 Barbiturates (long acting) 1-4 10 .015 ***** ***** ***** ***** Bupivacaine (Marcaine) 0.0015 0.147 ***** ***** ***** ***** Buspirone (Buspar) 0.0.07 0.345 0.088 .0. Vistaril) 0.0.0.0.01 .08 Blocadren (Timolol) 0.022 .125 400 .0025 .0.59 ***** ***** ***** ***** Bromide 0.26 1.150 20 200 40 400 Butisol (Butabarbital) 0.08 ***** ***** ***** ***** Benzedrex (Propylhexedrine) 0.2.14.0014 .4 -3.025 .0.011 0.73 7.2 .0.0.0006 0.004 .0035 .230 50-150 500-1500 200 2000 Bromide [met: Carbromal (Carbital)] 0.6 6 40 .2 Avelox (Moxifluxacin) 0.07 0.0.80 >10 >100 Barbiturates (intermediate acting) 0.2 .5 5 >0. 17 .88 2.0.0.0.50 0.0.2 22 C Cadmium 0.067 .7 Carisoprodol (Soma) 1-4 10 .01 .11 1.11 0.4 .0355 0.005 .0.6 6 ***** ***** Catapres (Clonidine) 0.0015 0.1.001 .0.550 0.0 1285 .017 2-3 20 .04 .0.1.00040 0.131 0.0002 .023 0.1250 128.125 400 .0011 0.31 ***** ***** 2-6 20 .67 6.00025 0.37 . Verapamil) 0.011 Chlor-Trimeton (Chlorpheniramine) 0.015 .9 0.5.0036 .0.150 ***** ***** ***** ***** Cardizem (Diltiazem) 0.8 ***** ***** Chlor-Trimeton (Chlorpheniramine) 0.31 ***** ***** 2-6 20 .0.0003-0.1.0.9.31 0.50 11 110 Cataflam (Voltaren.4 ***** ***** 2.5 .05 0.0.16 ***** ***** 0.0.0081 .016 0.0 1285 .00011-0.001 .6.040 0.005 0.4.5 .35% ***** 48-95% ***** [% Hemoglobin as Carboxyhemoglobin] Carbon Tetrachloride ***** ***** 2-5 20 .5 .0017 0.5 .1.09 0.2 .005 .12 10 100 25 250 ***** ***** 20 200 ***** ***** 0.363 20 .0.7 .2 2 .0.0.1.00017 0.024 .0.004 .0.055 .40 ***** ***** 0.1.081 .131 0.0.3 .0011 .32 ***** ***** ***** ***** Chloroprocaine (Nesacaine) 0.8.Drug and Chemical Blood Level Data .075 .0 .5 >15 >5 >50 Carbital (Carbromal) [as met: Bromide] 0.0025 0.36.0.10 Chlormepramine ***** ***** (plus metabolite .015 0.20 100 .00003-0.1 0.12 Chlorpropamide (Diabenese) 3.2450 Cardene (Nicardipine) 0.08 0.60 Carbamazepine (Tegretol) 0.0.0055 .1.030 0.0.1.40 4.0040 0.0.036 .0.032 0.051 .67 .010 0.0.8.0.0.15 .32 ***** ***** ***** ***** Chlorpromazine (Thorazine) 0.125 400 .245.49 1.2 .0.12 >1.500 7 .04 ***** ***** ***** ***** China White (Methylfentanyl) ***** ***** ***** ***** 0.20 ***** ***** 20 200 Chloroform 2 .006 0.0.3 30 .40 0.3 .017 ***** ***** 0.1.09 .004 0.02 .25 .0017 0.0.4 10 .2 .50 10 . Diclofenac) 0.30 0.055 0.032 0.75 .050 0.1 Caffeine 0.0.002 .2.51 .245.1 Page 3 .Norchlormepramine) Chlordane 0.01 .0.8 ***** ***** ***** ***** Chloromycetin (Chloramphenicol) 1-2 10 .20 0.028 .0.1 Chlorphentermine (Chlorophen) 0.05 .6 6 40 .75 200 .750 ***** ***** Chlorprothixene (Taractan) 0.3.13 0.200 Carbromal (Carbital) [as met: Bromide] 0.0.00005-0.2001 Therapeutic or Normal DRUG mg% Toxic ug/ml mg% Lethal ug/ml mg% ug/ml Butorphanol (Stadol) 0.2 3 .50 1 10 5 50 Carbon Monoxide 1 .1 .0.9 .0 .5 0.6 6 40 .04 .0.01 .2 1-2 0.61 3.0006 0.7 .4 .4 >44 ***** ***** [as met: Desmethylmethsuximide] Centrax (Prazepam) 0.9 Chlordiazepoxide (Librium) 0.0 0.0.0001 0.51 .40 0.0.50 20 .0005 .0017 ***** ***** ***** ***** Butyl Nitrite (Nitrite) 0.28 .20 Chlorcyclizine 0.40 3-5 30 .23 Celexa (Citalopram) 0.001 .14 .0.4 2-4 ***** ***** ***** ***** Chloroquine (Aralen) 0.00015 0.2 1.0.017 ***** ***** 0.05 .5 .0 2-10 ***** ***** >10 >100 Calan (Isoptin.04 0.2% ***** 15 .30 ***** ***** Chloral Hydrate (Noctec) 0.0.9 3 .05 .001 .05 .051 .355 0.05 .250 39 390 Chlorophen (Chlorphentermine) 0.1250 128.85 Captopril (Capoten) 0.3 Celontin (Methsuximide) 1.2450 Carbocaine (Mepivacaine) 0.01 .6 6 ***** ***** ***** ***** Chlorpheniramine (Chlor-Trimeton) 0.0.0.11 0.0.0.1 0.5 5 2 20 Chlormezanone (Trancopal) 0.0017 0.002 .60 Capoten (Captopril) 0.25 70 .55 [as met: Trichloroethanol] Chloramphenicol (Chloromycetin) 1-2 10 .24 .001 0.99 Chlorothiazide 0.50 . 1.53 Cylert (Pemoline) 0.46 ***** ***** 0.04 .07 .081 .036 ***** ***** >0.0 .024 .126 0.0.140 0.5 1-5 ***** ***** ***** ***** Claritin (Loratidine) 0.046 0.71 .71 0.1 .3 1-3 ***** ***** ***** ***** Dantrolene (Dantrium) 0.07 0.5 .0021 .684 >0.200 ***** ***** Desipramine (Norpramin) 0.0.1 .00300 0.144 ***** ***** ***** ***** [+met: N-Desalkylflurazepam] Dantrium (Dantrolene) 0.0.0.0003-0.0.4.0004 .0.00280 0.09 0.023 .6 0.0.00003-0.140 Toxic ug/ml 0.004 .007 .0.00003-0.1 .13 0.2 2.076 0.005 .0.005 .045 ***** ***** ***** ***** D Dalmane (Flurazepam) 0.10 50 .0003-0.1 ***** ***** ***** ***** Cresol ***** ***** ***** ***** 0.28 .05 .1 .0 1 .041 ***** ***** 0.6.16 ***** ***** 0.5 ***** ***** ***** ***** Citalopram (Celexa) 0.107 0.04 >0.4 >44 ***** ***** [met: Imipramine (Tofranil)] Desmethylmethsuximide [met: Celontin (Methsuximide)] Page 4 .5 0.21 .0 8 .00005-0.54 5.0.013 ***** ***** ***** ***** [+ met: Norpropoxyphene] DDT Demerol (Meperidine) 0.0015 .015 .0.4 0.2.30 0.0015 0.021 .0.90 9-19 Cyanide 0.1 .1.08 .90 .0.005 .23 Clorazepate (Tranxene) 0.63.80 0.5 .0075 0.23 .100 0.7 1-17 Darvon (Propoxyphene) 0.0.2.0003-0.034 0.0.7 Colbenemid (Colchicine) 0.102 .07 0.11 .21 .8 .0028 0.0 Dalmane (Flurazepam) 0.0.028 0.0041 0.030 0.0.5 5 Copper 0.5 5 0.0300 ***** ***** 0.0.31 1.0036 0.40 ***** ***** ***** ***** Compazine (Prochlorperazine) ***** ***** >0.080 0.0771 0.016 0.0028 0.40 4.3.0.0.0.70 .6.25 Colchicine (Colbenemid) 0.0.0.021 .0.03 .2 0.40 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** Cimetidine (Tagamet) 0.1 .25 Combipress (Chlorthalidone) 0.0.5 1-2 10 .4 16 .0.00015 0.0. 0 .0 ***** ***** [as met: N-Desmethyldiazepam Clozapine (Clozaril) 0.025 0.10 .27 .930 0.00300 0.02 0.0.03 .05 .45 ***** ***** ***** ***** Clonazepam (Klonopin) 0.0.0.62 0.0.0006 0.0.1 >1 0.4.0007 .8 .0.30 2.1.0684 0.0126 0.1 .24 .0013 0.003 .093 0.0.4 .028 0.20 1.023 0.5.02 .0007 .7 2.34 ***** ***** >0.15 1.0.0033 .104 .6 Cogentin (Benztropine) 0.0.771 ***** ***** ***** ***** Clozaril (Clozapine) 0.0.05 .102 .3 1.0.0 Coumadin (Warfarin) 0.07 .47 0.3.1.0.0771 0.1.5 4-5 ***** ***** ***** ***** Clofibrate (Atromid) 12.10 .4 Cyclopropane 8 .0.0102 .0.16 0.007 .0102 .76 1.01 .4.7 .1 .6 >0.025 0.0.0.3 Citanest (Prilocaine) 0.0.20 Codeine 0.0.075 ***** ***** ***** ***** Clonidine (Catepres) 0.021 .1.021 .3 1-3 ***** ***** ***** ***** Darvon (Propoxyphene) 0.06 0.0.2 122 ***** ***** ***** ***** Clomipramine (Anafranil) 0.1.0 7.003 .0144 0.007 .03 .0.5 .0280 0.6 .1.12 0.006 0.1.180 ***** ***** ***** ***** Cyclosporine (Sandimmune) 0.05 >0.2001 Therapeutic or Normal DRUG Chlorthalidone (Combipress) mg% 0.0.008 .048 0.0.0.0.9 0.0045 0.0.3 .46 ***** ***** Clinoril (Sulindac) [metabolite: descarboethoxyloratadine] 0.0.20.0.0.25 .045 0.0.0300 ***** ***** 0.40 0.007 .16 >1.0081 .0048 0.18 80 .20 Depakene (Valproic Acid) 5 .0007 .01 .0005 .1 .033 .05 .2 .371 1.0021 .5 15 Cyclobenzaprine (Flexeril) 0.771 ***** ***** ***** ***** Cocaine 0.0.45 0.05 .5 >5.Drug and Chemical Blood Level Data .046 0.0.00003-0.2 ***** ***** ***** ***** Cyclizine 0. 063 .61 3.0022 0.038 0.03 .02 .10 0.0025 .1.5 ***** ***** 37 .0500 0.0.0.5.50 >10 >100 Dilaudid (Hydromorphone) 0.002 .0015 .10 .580 Dolophine (Methadone) 0.0.08 ****** ***** ***** ***** Didrex (Benzphetamine) 0.00040 0.2.07 .2 ***** ***** ***** ***** Doxepin (Sinequan) 0.025 0.0.0.5 .8 >8 Diphenoxylate (Lomotil) 0.008 0.2 0.1 .03 .3.0015 0.01 .148 ***** ***** ***** ***** Doriden (Glutethimide) 0.9 .025 0.52 2.002 .0.04 ***** ***** ***** ***** Diphenylhydantoin (Phenytoin.110 0.02 0.420 ***** ***** 0.2 2 .0.Drug and Chemical Blood Level Data .3 0.7 .00030-0.15 .75 200 .025 .7 Dimetane (Brompheniramine) 0.5 Doxapram (Dopram) 0.0.0112 0.2.05 .5 .27 .0.5 .0.5.27 .7 .0035 .0.58 370 .9 8 .600 Diclofenac (Voltaren.0.1.200 ***** ***** 0.04 .0.20 2-5 20 .8 .0008 .0.0.50 >10 >100 Diprivan (Propofol) 0.0.14.0200 0.4 .2 ***** 0.05 .04 .13 9 .580 Divinyl Oxide ***** ***** ***** ***** 70 700 DMSO (Dimethylsulfoxide) 5.1.25 0.6 2 -26 Doxepin (Sinequan) 0.12 .25 0.3380 ***** ***** 160 .0.0.2001 Therapeutic or Normal DRUG Desyrel (Trazodone) mg% 0.35 [+met: N-Desmethyldoxepin Page 5 .003 .7 .038 .67 6.20 0.4.0.5 75 Diphenhydramine (Benadryl) 0.022 0.05 >0.63 .0007 .001 .0 0.0.5 5 .0.60 95 .0.7 0.03 0.0.6.0.0008 .0 .6 2-6 0.07 .7 .2.4.0.7 .016 0.37 .00015 .2.0.6.002 0.0.4 Difenoxin (Motofen) 0.049 **** ***** 0.0.0 15 .8 11 .8 .5 .89 mg% ***** Lethal ug/ml ***** mg% 1.363 20 .5 8 .2.20 Dihydrocodeinone (Hydrocodone) 0.04 .338 50.0.300 1600 .15 ***** ***** ***** ***** Diazepam (Valium) 0.0420 0.3380 ***** ***** 160 . Diphenylhydantoin) 1-2 10 .031 .0.0.38 ***** ***** >0.100 Dothiepin (Prothiaden) 0.4 14 Dieldrin 0.33 ***** ***** ***** ***** Diamox (Acetazolamide) 1.13 9 .31 .3 >3 Diabenese (Chlorpropamide) 3.0 .2 .58 370 .3 30 .59 7 70 ***** ***** Dicyclomine (Bentyl) 0.0025 .0.25 >0.130 ***** ***** 37 .130 ***** ***** 37 .1 0.0030 .0 5 .015 ***** ***** ***** ***** Dimethylsulfoxide (DMSO) 5.1.4.035 .007 .05 .1.0.2 0.5 5 >0.02 .338 50.0007 .004 0.2 .0.3000 Dimethyltryptamine 0.0.5 .00 0.017 .160 ***** ***** ***** ***** Diflucan (Fluconazol) 0.6 2 .303 0.100 ***** ***** ***** ***** Dinitro-O-Cresol ***** ***** 3-6 30 .0.0. Dilantin) 1-2 10 .0.075 .12 1-8 10 .8 ***** ***** Doral (Quazepam) 1.18 0.07 .54 5.2.5 ug/ml 15 Dextromethorphan 0.05 >0.4.0 0.2 .1.025 .80 3 .010 .60 7.5 0.0.012 .6 26 Disulfiram (Antabuse) 0.580 Digoxin 0.001 .489 Toxic ug/ml 0.16 Diethylpropion (Tenuate) 0. Cataflam) 0.40 0.0.3 Diltiazem (Cardizem) 0.0.0100 0.0.0001 .38 .075 .27.0017 .7 .5 10 .2 0.112 0.20 >10 >100 ***** ***** Diazinon ***** ***** ***** ***** 0.75 .0.1.52 2.0.750 ***** ***** Diacetalol 0.2 .433 0.400 0.12 Dilantin (Phenytoin.0.6 6 ***** ***** Dicumarol 0.0.7 7 2.5.20 .015 .04 0.277 Dichloromethane (Methylene Chloride) ***** ***** ***** ***** 9.43 0.4 .02 .20 2-5 20 .0040 0.300 1600 .025 0.36.00007-0.58 370 .15 ***** ***** ***** ***** Diflunisal (Dolobid) 0.600 0.0.0075 .25 0.4 .2 0.04 .0.10 30 .0303 0.116 0.0.20 >3 >30 Diazepam (Valium) 0.0049 0.9 .25 0.1.4 >34 [+ met: N-Desmethyldiazepam] Diazoxide (Hyperstat) 1.010 .3 .5 .008 .8 Dopram (Doxapram) 0.2.500 >0.00 ***** ***** >3.02 0.0.008 .0.3000 Dolobid (Diflunisal) 0.5 1.16 ***** ***** ***** ***** Disopyramide (Norpace) 0.10 .005 .0. 085 .2 ug/ml 0.2 .0.3 .0015 0.6 27 .6.5 ***** ***** Elavil (Amitriptyline) 0.1000 ***** ***** 140 .15 Fenoprofen (Nalfon) 2.0.075 0.15 1 .05 >0.12 Duranest (Etidocaine) 0.43 6.0.1.0.0.40 1.1 .10 40 .17 .04 .001 .00088 0.15 0.10 ***** ***** 0.0032 0.0.393 0.05 >0.27 .063 .5 ***** ***** ***** ***** Etodolac (Lodine) 1.5 .213 Ethinamate (Valmid) 0.019 ***** ***** ***** ***** [met: O-Desmethylvenlafaxine] [+met: Nortriptyline] Eldepryl (Selegiline) Emetine 0.0138 Toxic ug/ml 0.00 ***** ***** ***** ***** Felodipine (Plendil) 0.7 .0075 0.4 7 .22 ***** ***** ***** ***** Flucanzol (Diflucan) 0.65 .25 >0.27 .0007 .26 1.8 0.1890 Ethylene Glycol ***** ***** 150.4.3.1.6 13 .30 200 .28 ***** ***** ***** ***** 0.7 .138 mg% ***** Lethal ug/ml ***** mg% 0.0.0 2 .0069 .012 .0.0 200 .0.07 .17 .100 900 .05 .20 100 .2.06 .1.3 2.85 .47 ***** ***** ***** ***** F Famotidine (Pepcid) 0.0.13 ***** ***** ***** ***** Flubiprofen (Ansaid) 1 .3 3 .21 Estazolam (Prosom) 0.1 4 .0 1500.3 .6 ***** ***** 71 710 Fentanyl (Sublimaze) 0.14.4 Flexin (Zoxazolamine) 0.00015-0.2.0.1 .0.20 Elavil (Amitriptyline) 0.04 >0.010 0.007 .6 0.3.Drug and Chemical Blood Level Data .0.0100 0.5 .26 Flecainide (Tambocar) 0.200 ***** ***** Feldene (Piroxicam) 0.2 .0042 .0.6 .09 0.3.036 ***** ***** >0.012 .0007 .20 140 .004 .3 22 .10 ***** ***** ***** ***** Fexofenadine (Allegra) 0.8 ***** ***** 2.0.018 .20 0.07 .8.5 .2 .0.125 1.6 21 .100 800 .0.0.007 .003 0.0 2 .0088 0.0.030 0.3 2.0 ***** ***** ***** ***** Flexeril (Cyclobenzaprine) 0.33 14 .8.0009 .7 .12 .24 2.2.40 1.0.0.1 .0.11 ***** ***** 10 .5 5 -15 ***** ***** ***** ***** Page 6 .0.061 .18 .2.0061 .0.0.015 ***** ***** Fenfluramine (Pondimin) 0.3 0.33 14 .2 .3 ***** ***** ***** ***** 0.0.1.56 ***** ***** ***** ***** Dyphylline 0.9 0.070 ***** ***** ***** ***** Encainide (Enkaid) 0.01 .7 .7 .1.6 36 ***** ***** E Effexor (Venlafaxine) 0.042 .4 Enalapril (Vasotec) 0.10 0.7 .6 0.1.001 .3 3.12 .007 .0.0.0.2.045 0.4 7 .035 ***** ***** ***** ***** Felbamate (Felbatol) 0.26 1.5 .0.2001 Therapeutic or Normal DRUG Doxylamine (Unisom) mg% 0.0.05 .0.0.0035 0.1000 >350 >3500 intoxication for driving in most states) Ethchlorvynol (Placidyl) 0.069 .2 10 .075 ***** ***** 0.0.0.01 .1.5 .025 0.0019 0.0003 0.7 12 .05 .5 6 .200 Ethosuximide (Zarontin) 4 .0.6 13 .4 .03 0.5 0.007 0.01 .100 ***** ***** 25 250 Ethyl Chloride 20 .0.021 0.5.0.0015 .0.4000 Etidocaine (Duranest) 0.0.7 .7 .028 0.3 .1.0.20 140 .1.300 ***** ***** 40 400 Ethyl Ether 90 .0036 0.2.7 .05 .07 .005 .21.75 0.006 .6.88 0.025 0.01 0.0.5 ***** ***** ***** ***** Dymelor (Acetohexamide) 2.25 ***** ***** Ethanol (listed toxic concentration is legal ***** ***** 80 .0.0.210 ***** ***** ***** ***** Fioricet (Butalbital) 0.26 Fiorinal (Butalbital) 0.1.200 ***** ***** Felbatol (Felbamate) 0.5 0.93 ***** ***** ***** ***** 0.100 0.45 {as met: O-Demethylencainide] Encainide (Enkaid) [as met: Methoxy-O-demethylencainide Endrin Ephedrine 0.0068 .2.400 2000 .0.2 .1 3.0015 .189 1400 .009 .015 .35 .0.25 >0.02 .15 0.2.0.5 .032 0.0063 .068 .0. 007 .2 .0 2.0.02 .0 .8 ***** ***** ***** ***** Fortavase.003 .3.0004 .39 Hyoscine (Scopolamine) 0.05 .2 2 .35 Hismanol (Astemizole) 0.09 0.0234 0.031 .3 .25 0.0.38 ***** ***** ***** ***** Hydrocodone (Lortab.0003 .092 0.00280 0.5 2.260 ***** ***** 20 200 Hexachlorophene (Phisohex) 0.0.0 15 .001 0.8 Fluphenazine (Prolixin) 0.0.2 .3 Hydroxychloroquine (Plaquenil) 0.0280 0.360 >75 >750 GHB (Gamma-Hydroxybutyrate) <0.105 0.07 .0.4 ***** ***** 1.0.0 Flurazepam (Dalmane) 0.0 ***** ***** ***** ***** Furadantoin (Nitrofurantoin) 0.0170 ***** ***** ***** ***** Flurazepam (Dalmane) 0.008 0.4.0.1.0.0.6 .1 <1.015 .36 26 .002 0.2001 Therapeutic or Normal DRUG Flumazenil (Mazicon.01 ***** ***** ***** ***** H Habitrol (transdermal) (Nicotine) 0.0245 0.00009-0.052 0.2 .00003 .1.08 ***** ***** 0.100 Glycopyrrolate (Robinul) 0.09 .28 .2 0.0.0 22 .033 .07 .0 1 .38 ***** ***** ***** ***** Hydrogen Sulfide ***** ***** ***** ***** 0.025 0.11 0.5 .0650 0.1.005 0.0095 0.40 0.0 .7 .011 .0052 0.024 .0.12 Hydrodiuril (Hydrochlorothiazide) 0.0.038 0.80 3 .0004 ***** ***** ***** ***** Hydralazine 0.0014 .0019 .2 0.0.4 .0.05 .5 Page 7 .06 .14 1.4 Halcion (Triazolam) 0.005 .85 2.0.18 1.5 0.0.4 1-4 4.0.049 **** ***** 0.0.050 0.2 .0005 .20 >10 >100 ***** ***** 1.22 .2.0.0105 0.050 .0.001 .0.68 1.144 ***** ***** ***** ***** [+met: N-Desalkylflurazepam] Fluvoxamine (Luvox) 0.0444 0.92 Hydromorphone (Dilaudid) 0.04 0.5 .5 .0.005 .05 .0144 0.650 ***** ***** 0.26.0.05 ***** ***** Fluoride 0.0049 0.7 .050 0.10 30 .Drug and Chemical Blood Level Data .00170 0.014 .0 20.50 ***** ***** Haloperidol (Haldol) 0.1.006 .0 2 .0006 .038 0.4 21 210 ***** ***** Guanethidine (Ismelin) 0.700 ***** ***** I Ibuprofen (Motrin) Imitrex (Sumatriptan) 0.4.039 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** Flunitrazepam (Rohypnol) 0.0.8 .0008 .0.0031 .10 >2 >20 ***** ***** G Gabapentin (Neurontin) 0.11 .0.0.89 Hyperstat (Diazoxide) 1.02 ***** ***** ***** ***** Haldol (Haloperidol) 0.0.0.6 .04 . Vistaril) 0.076 ***** ***** ***** ***** Gold (Sodium Aurothiomalate) 0.05 .0006 .0.03 0.0.0.006 .040 0.1 61 Hydroxyzine (Atarax.9 17 .1.0245 0.70 84 .0087 0.360 >75 >750 Glucophage (Metformin) 0.0.189 1.0210 0.26.70.0.210 ***** ***** 6.095 ***** ***** ***** ***** Imipramine (Tofranil) 0.0.0 45 .6.1 <1.0.0.0.20 15 .05 .003 .0.245 0.70 ***** ***** Glutethimide (Doriden) 0.1.0.4 . Vicodin) 0.200 Fluothane (Halothane) 2.0.0009 .1 .2 .0003 . Romazicon) mg% 0.3 .0.004 .0.50 ***** ***** Halothane (Fluothane) 2.0.0039 Toxic ug/ml 0.0019 0.0.14 0.234 ***** ***** ***** ***** Gamma-Hydroxybutyrate (GHB) <0.0.2 .15 0.0.0 2.03 .0.2 0.0.0.1.444 ***** ***** 0.8.7.006 .0.022 .9 ***** ***** ***** ***** Hydrochlorothiazide (Hydrodiuril) 0.5 .0006 .7.001 .40 ***** ***** 0.2 0.006 .10 ***** ***** ***** ***** Gabitrol (Tiagabine) 0.15 .0001 .0076 0.1 .0.0033 .0.245 0.0022 .019 ***** ***** 0.5 .0.260 ***** ***** 20 200 Fluoxetine (Prozac) 0.0 22 .0.019 .009 .5 .9 4.1 ***** ***** ***** ***** Furosemide (Lasix) 0.13 .8 3-8 ***** ***** ***** ***** Guaifenesin (Robitussin) 0.02 0.0.0.0.087 ***** ***** ***** ***** Forane (Isoflurane) 2.2 .07 .0.0024 .005 .00004 0. Invirase (Saquinavir) 0.0.0.00005-0.008 .49 8.36 26 .01 .4 -3.007 .12 1-8 10 . 0021 0.5 .0028 0.6 ***** ***** Lortab (Hydrocodone.1.0.001 .03 .3 Lioresal (Baclofen) 0.5 ***** ***** Lisinopril (Prinivil.1 .0.2.0.01 .04 0.0.293 0.10 >2 >20 ***** ***** L Lead 0.0. Fortovase (Saquinavir) 0.024 0.20 .1 .5 ***** ***** ***** ***** Ketorolac (Toradol) 0.036 .5 .7.14.09 0.02 .0.0.7 .47 >34.2 0.27 0.0 ***** ***** ***** ***** Isoniazid (INH) 0.001 .0075 0.2.8 .038 ***** ***** ***** ***** Isosorbide Dinitrate (Isordil) 0.1.142 Loratadine (Claritin) 0.15 .53 1.0271 0.27 .6 0.0.3 ***** ***** ***** ***** Ketoprofen (Orudis.0.05 .025 0.11 .40 0.20 2 .8 .05 0.0.08 .0007 .055 .97 4.25 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** [+met: Desipramine] Inderal (Propranolol) 0.36 ***** ***** Lamotrigine (Lamactal) 0.0.0036 .0.5.0007 .0007 .004 0.13.0 0.087 .63 0.47 .07 .77 1.0.1 .0.9 .0.93 0.0.4 0.7 0.038 ***** ***** ***** ***** 0.50 Ismelin (Guanethidine) 0.0.0.0038 0.0007 .0.6 6 ***** ***** Indomethacin (Indocin) 0.011 .03 ***** ***** 0.0.5 ***** ***** 0.0355 0.14.008 .5 .1.2 0.20 >2.028 0.168 Invirase.6 .76 1.09 .7.2.0007 .5 .0.2 .015 .0.5 .4.46 ***** ***** 0.0038 0.15 .027 .01 ***** ***** ***** ***** Isoflurane (Forane) 2.002 .02 .0.001 .7 Librium (Chlordiazepoxide) 0.0 0.028 0.075 ***** ***** ***** ***** Kwell (Lindane) 0.0.3 20 .0. Vicodin) 0.168 Isopropanol ***** ***** >40 >400 >150 >1500 Isoptin (Calan.8 .355 0.5 2.8.4 0.08 .01 .0.6.0.0271 0.0.007 .034 0.0028 0.0.7 Page 8 .9 .04 ***** ***** ***** ***** Lopressor (Metoprolol) 0.05 0.14.47 ***** ***** ***** ***** Lomotil (Diphenoxylate) 0.0.0.06 .271 ***** ***** ***** ***** Levorphanol (Levo-Dromoran) 0.08 .6 15 .5 >25 Lindane (Kwell) 0.025 Toxic ug/ml 0.2 7 .143 6.0008 .09 . Verapamil) 0.13 1.9.1 .7.008 .90 2 .0.271 ***** ***** ***** ***** Lamactal (Lamotrigine) 0.2.0.0.001 0.36 ***** ***** Lasix (Furosemide) 0.0.1.5 .39 13.9 .01 .67 .34 0.24 0.6 15 .0001 .7 Lodine (Etodolac) 1.0.0.007 .2001 Therapeutic or Normal DRUG Imipramine (Tofranil) mg% 0.90 2 .009 .0.1.5.11 0.01 .6 6 ***** ***** INH (Isoniazid) 0.63 ***** ***** ***** ***** K Kemadrin (Procyclidine) Ketamine 0.0055 .85 Isordil (Isosorbide Dinitrate) 0.2 8 .0.16.70 0.7 .46 ***** ***** metabolite: descarboethoxyloratadine) Lorazepam (Ativan) 0.007 .007 .051 0.0008 .7.50 1.42 .06 0.03 .1 .0.2 .5 .1 ***** ***** ***** ***** Ionamin (Phentermine) 0.11 .15 5 .3.9 0.0 20.35 1.007 .2 4.0.09 .3 .6 Iron 0.0. Trandate) 0.12 Indocin (Indomethacin) 0.28 .1.0.25 0. Actron) 0.06 .27 ***** ***** 0.6 .0.7 Levoprome (Methotrimeprazine) 0.002 .031 0.2 .27 0.001 .031 0.0.5 5 2 20 Lidocaine (Xylocaine) 0.0001 .7 12 .5 0.20 .0.0.0.021 ***** ***** 0.003 0.04 .0.003 .7 .0.2 0.12 Loxapine (Loxitane) 0.0.8 65 .0.3 Labetalol (Normodyne.021 ***** ***** 0.0 1 .0 Levo-Dromoran (Levorphanol) 0.51 ***** ***** 0.2.0.0.2 2 0.01 .046 0.19 1.2.3 20 .Drug and Chemical Blood Level Data .03 .046 0.1 0.31 0.0.0031 0.37 0.0 .06 0.1.3.87 .0082 0.4.01 .003 .0021 0.16.0 0.001 .0.13 1.082 ***** ***** ***** ***** Lithium 0.0.3.5 .5 ***** ***** ***** ***** Klonopin (Clonazepam) 0.7 1.5 0.143 6.11 .001 .0.20 2 .15 .05 <0.9 >3.0.1 .0.01 .02 .0.25 2-5 20 .0.5 0.4 0.8 65 .0.0.0.70.19 .0. Zestril) 0.3.4 .3 Leritine (Anileridine) <0.008 .8 .0 .067 .0031 0.45 0.19 1.027 0.40 0.063 0.1. 005 .0.0271 0.0. Romazicon) 0.03 .3.1.6 296 ***** ***** ***** ***** Metformin (Glucophage) 0.3 .40 0.0.02 .20 0.0.0.0.0075 .0.0.05 .0009 0.22 .4.0002 .26 0.35 0.0 11 .2.35 0.0.62 0.00011 0.0.087 Lysergic Acid Diethylamide ***** ***** 0.4 .031 .2 0.5 ***** ***** ***** ***** Mepivacaine (Carbocaine) 0.0009 0.003 0.352 1.0.072 .10 0.0087 0.002 .10 60 -100 14 .0001 .04 .075 .6 0.0.40 5 50 ***** ***** [+met: N-Desmethylmephenytoin] Mephobarbital (Mebaral) 0.5.2.7 LSD (Lysergic Acid Diethylamide.5 5 0.52 ***** ***** 0.0011 0.20 Mephenytoin (Mesantoin) 2.0001 .0.80 0.08 .1.8 .0 1.50 1 10 5 50 Meprobamate 0.005 .28 .80 0.080 0.024 .05 .05 .3 3 Mestinon (Pyridostigmine) 40 400 ***** ***** ***** ***** Metaclopramide (Reglan) 0.006 .5 .028 0.9 .0.0.1 . Lysergic Acid Diethylamide) M Magnesium Malathion 0.3 2-13 Marcaine (Bupivacaine) 0.001 .080 0.01 .007 .12 80 -120 20 .0.4.32 200 -320 (LSD.0 25 .009 ***** ***** 0.5 .0 Mercury (Organic) <0.0.24 .5 .718 0.28 ***** ***** ***** ***** [met: Encainide] Page 9 .4 .5 >5 Methazolamide (Neptazane) 4 40 ***** ***** ***** ***** Methocarbamol (Robaxin) 2.0.26 6 .0.018 .07 3.02 .1 .0.06 .008 <0.009 ***** ****** ***** ***** 0.41 0.8 Methamphetamine 0.0.0072 .009 ***** ***** 1.0.001 .2 .46 4.04 .2 .2 .0.550 0.024 .0.028 .0.2 .3.4.6 1.718 Luvox (Fluvoxamine) 0.18 .6 .006 .345 0.06 .70 ***** ***** Methadone (Dolophine) 0.6 ***** ***** Maprotiline (Ludiomil) 0.0.3.1 .6 2 .0 8 .35 0.1.4 .5 .0009 0.00002-0.18 .3.8 .005 0.0.0718 0.41 ***** ***** ***** ***** Methohexital 0.7.03 .4-Methylenedioxyamphetamine) ***** ***** ***** ***** 0.8 98 Methotrimeprazine (Levoprome) 0.1 26 .0.001 .1 Methoxy-O-demethylencainide 0.110 ***** ***** Mellaril (Thioridazine) 0.4 .19 .0.18 Mellaril (Thioridazine) 0.20.5 .05 .1.04 .20 .0 1-3 10 .0031 .0 >1 >10 Methanol ***** ***** 20 200 >89 >890 Methaqualone (Quaalude) 0.05 .0.4 .080 0.1.2.5 ***** ***** ***** ***** Mefenamic Acid (Ponstel) 0.8.01 .5 ***** ***** 0.271 ***** ***** 0.0039 0.0.1 .5 .5 Manganese [serum values] 0.0 45 .0.00 0.0.075 0.0.03 ***** ***** 0.4 1-4 4.26 Mebaral (Mephobarbital) 0.40 5 50 ***** ***** [+met: N-Desmethylmephenytoin] Mesoridazine (Serentil) 0.4.0006 . Lysergide) Lysergide (LSD.3.0 .5.6 Mesantoin (Mephenytoin) 2.062 0.350 Mercury (Inorganic) ***** ***** 0.18 0.02 >0.06 >0.7.0718 0.0.110 0.8 1 .0.0.11.0.1.7 ***** ***** 9.022 .0.24 .0.0.50 0.0.07 .34 .001 .3.22.0.35 0.08 >0.0 25 .039 ***** ***** ***** ***** MDA (3.3 .Drug and Chemical Blood Level Data .05 0.8 .11.3.1.80 0.2.2 >0.35 140 .45 1 10 ***** ***** Mazicon (Flumazenil.80 0.18 .01 .0001 .8 0.2.0 ***** ***** ***** ***** [+met: Mesoridazine] Meperidine (Demerol) 0.24 .75 ***** ***** ***** ***** Metaxalone (Skelaxin) 29.3 2-13 Lysergide) Ludiomil (Maprotiline) 0.0.0.0.10.2001 Therapeutic or Normal DRUG mg% Toxic ug/ml mg% Lethal ug/ml mg% ug/ml Loxitane (Loxapine) 0.6 .30 >0.001 .0.2 12 -32 8 .0 0.0.2.0.18 2.2.0 .77 1. ***** ***** 0.0.4.118 . 0.180 0.6 .0.0 ***** ***** 2.05 .0.0 .1 .23 2.011 Methylphenidate (Ritalin) 0.6 27 .60 10 100 Metoprolol (Lopressor) 0.0.01 ***** ***** ***** ***** NAPA (N-Acetylprocainamide) 0.16.4 Lethal ug/ml >44 mg% ***** ug/ml ***** [as met: Desmethylmethsuximide] Methyldopa 0.1 .75 1.01 .2 .6 16 ***** ***** [met: Procainamide (Pronestyl) Naprosyn (Naproxen) 3.002 .8 0.0.20 0.014 0.01 .0.9 10 .0001 .05 .1.120 40 400 ***** ***** Narcan (Naloxone) 0.4.5 21 .1 .005 .01 .4 .40 mg% 4.001 .90 Molybdenum 0.2 2 .01 .3 Methyprylon (Noludar) 0.4.12 0.5 Navane (Thiothixene) 0.1.2.6 Midazolam (Versed) 0.001 .10 ***** ***** 0.0.9.26 0.6 >0.2 .0 .2 ***** ***** ***** ***** Nembutal (Pentobarbital) 0.0 56 .0.47 .6 .3 1-3 >0.1.5 >5 1.001 .6.015 ***** ***** ***** ***** Morphine 0.4 Toxic ug/ml 10 .0.00 Motrin (Ibuprofen) 1.120 40 400 ***** ***** Naproxen (Anaprox) 3.0 2 .12 1.9 2 .2.7.4 ***** ***** ***** ***** Mysoline (Primidone) 0.26 0.1 .0.700 ***** ***** Motofen (Difenoxin) 0.0.50 0.027 0.0.0039 .0.1 .18 .0.6 1.45 .5 >5 ***** ***** 0.08 0.15 3-6 30 .5 .0.80 10 100 0.16 .4 .14.016 0.27 ***** ***** 0.0002 0.039 .001 0.7 .0 ***** ***** 2.01 ***** ***** ***** ***** Nardil (Phenelzine) 0.45 Mexitil (Mexiletine) 0.12 1.001 0.025 0.0.20 0.2 2 .2.25 ***** ***** ***** ***** Milontin (Phensuximide) 0.0.600 3-4-Methylenedioxyamphetamines (MDA) ***** ***** ***** ***** 0.26 Methylfentanyl (China White) ****** ****** ****** ****** 0.5 1 10 ***** ***** Methylene Chloride (Dichloromethane) ***** ***** ***** ***** 9.0.78 1.0.14.003 .0.0.5 .400 0.01 0.001 .66 ***** ***** 71 710 Naloxone (Narcan) 0.2.11 .0.160 ***** ***** ***** ***** Moxifluxacin (Avelox) 0.5 21 .6 16 ***** ***** 0.0.1.1.44 4.8 ***** ***** ***** ***** Nefazodone (Serzone) 0.Drug and Chemical Blood Level Data .2001 Therapeutic or Normal DRUG Methsuximide (Celontin) mg% 1.2.7 .4.002 ***** ***** >0.45 Mianserin 0.1.006 0.0.2 4.1 .49 8.0.5 .0 .4 4 .0015 0.18 ***** ***** ***** ***** Moclobemide 0.0.08 .12 31 .150 ***** ***** Mirtazapine (Remeron) 0.15 80 .14 ***** ***** ***** ***** 0.80 ***** ***** ***** ***** N N-Acetylprocainamide (NAPA) [met: Procainamide (Pronestyl) N-Desalkylflurazepam [met: Flurazepam (Dalmane)] N-Desmethyldiazepam (Nordiazepam) [met: Clorazepate (Tranxene)] N-Desmethyldiazepam (Nordiazepam) [met: Diazepam (Valium)] Nalfon (Fenoprofen) 2.001 .2 .03 .1.4.3 3 ***** ***** 5.1 .010 0.016 0.7.7 .10 ***** ***** ***** ***** Nebcin (Tobramycin) 0.06 0.12 31 .14 8 .011 .70 84 .003 0.050 0.8 .15 >1.5 .5 5 .5 .0002 .0.008 .05 .1 .2 .02 .19 5-8 50 .0011 0.01 .4 2-4 ***** ***** ***** ***** Neurontin (Gabapentin) 0.142 Mexiletine (Mexitil) 0.01 .0.01 .10 .0.10 ***** ***** ***** ***** Page 10 .0.0.2 .169 Neo-Synephrine (Phenylephrine) 0.9 17 .16 0.1.018 0.002 .03 ***** ***** ***** ***** Neptazane (Methazolamide) 4 40 ***** ***** ***** ***** Nesacaine (Chloroprocaine) 0.60 95 .1. 14 1.0444 0.0036 .0 .02 .0.005 .036 .85 0.0004 .013 ***** ***** ***** ***** Nitroprusside [as met: Thiocyanate] 0.0.0160 .2 .1 >21 ***** ***** O O-Demethylencainide [met: Encainide] 0.5.3 13 0. Percodan) 0.0013 0.0 ***** ***** Oxycontin (Oxycodone.15 3-6 30 .031 ***** ***** ***** ***** (Prostep.5 >5.12 1.0.015 .5 1.0013 0.0 .11.2001 Therapeutic or Normal DRUG Nicardipine (Cardene) mg% 0.0.0.0.0.0.003 .0004 .0.5 1-2 10 .180 0.05 .0.40 0.0.0.2 2 .160 .0.0009 .0.466 ***** ***** 0.0.0.0018 .60 10 100 Nordiazepam (N-Desmethyldiazepam) 0.015 .2 >2 ***** ***** Oxycodone (Percodan.085 0.0.0.0.02 .01 .10 0.0 ***** ***** ***** ***** Novocaine (Procaine) 0.5.87 .20 0.8 11 .0114 0.5.5 .1.0.0022 .2 .0.0.01 .1 .100 0.13.9.0.0.005 .0.0207 0.1.5 .162 ***** ***** ***** ***** Nisentil (Alphaprodine) 0.002 .50 0.2 .004 .0 >2.004 .0.2 .4 .1. Habitrol.0023 0.03 .3 .013 ***** ***** ***** ***** Nitrofurantoin (Furadantoin) 0.6 >0.7 7 2.15 .0.0002 .44 290 .05 .002 .010 0.0031 0.0162 0.002 .440 ***** ***** 35 350 Noctec (Chloral Hydrate) 0.011 0.0.444 ***** ***** 0.0 ***** ***** Oxyphenbutazone (Tandearil) 1.2 Ondansetron (Zofran) 0.087 .0375 0.26 0.03 .0.0.6 43 .0 ***** ***** 0.0.2.01 .9 .1 .0.003 . Nitroglycerin) 0. Nitroglycerin) 0.0002 .6.85 0. Nicotine) 0.0002 .010 0.0.4 Oxazepam (Serax) 0.1.1 .03 0.55 .4 ***** ***** 2.02 .375 0.29 >10 >100 20 200 Nitrous Oxide 29 .0. Trandate) 0. Oxycontin) 0.0031 0.0.12 10 100 25 250 Noludar (Methyprylon) 0.96 ***** ***** 64 640 Orphenadrine (Norflex) 0.11 10 .8.8.114 ***** ***** ***** ***** Orinase (Tolbutamide) 4.0 Orudis (Ketoprofen) 0.04 0.1.1 .002 .05 >0.036 .0.5 5 .2 2 0.0.1.001 .2 .0. Isoptin)] 1.0.02 .0013 0. Nitro-Dur) 0.5 ***** ***** ***** ***** ***** ***** 1 .0004 .0 Norfluoxetine [met: Fluoxetine (Prozac)] 0.0.150 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** Nickel 0.031 ***** ***** ***** ***** Nifedipine (Adalat.4 >0.0.0.80 ***** ***** ***** ***** [as met: Trichloroethanol] [met: Clorazepate (Tranxene)] Nordiazepam (N-Desmethyldiazepam) [met: Diazepam (Valium)] Norflex (Orphenadrine) 0.004 .8 4-8 1 10 >2 >20 Norvir (Ritonavir) [met: Verapamil (Calan.8 4.140 0.18 1.0466 0.5 .09 .0.8 ***** ***** ***** ***** Nitroglycerin (Nitro-Bid.0.8 4.018 . Nicotrol) Nicotrol (Transdermal.10 0.0.6 26 Norpramin (Desipramine) 0.0.015 Toxic ug/ml 0. Procardia) 0.0.4 .207 ***** ***** ***** ***** [met: Imipramine (Tofranil)] Nortriptyline (Aventyl) [met: Amitriptyline (Elavil)] Norverapamil 0.023 ***** ***** 0.2.022 .684 >0.0.001 .2 22 Nitro-Bid (Nitro-Dur.Drug and Chemical Blood Level Data .118 ***** ***** ***** ***** Page 11 .0.05 0.2 .0.30 0.1.013 ***** ***** ***** ***** Nitro-Dur (Nitro-Bid.1 .0.15 5 .0.0.0.0 Normodyne ( Labetalol.9 5.2 2 0.0684 0.0015 .4 .01 .11 ***** ***** ***** ***** Nicotine 0.05 .0036 .00 ***** ***** ***** ***** Nitrite (Butyl Nitrite) 0.3 ***** ***** ***** ***** Olanzapine (Zyprexa) 0.271 ***** ***** ***** ***** Norpace (Disopyramide) 0.5 0.66.0271 0.009 .5 .6 2-6 0.2 2 Oxaprozin (Daypro) 0.01 .4 Nicotine (Transdermal) 0.50 0.0.110 Oxalate 0.6 11.085 0. 62 0.003 0.5.9 Polythiazide (Renese) 0.4.0015 0.0.0650 0.02 .3.0.4 Pavulon (Pancuronium) 0.0.0 .0.001 .5 .0.4 .0.5 1-5 Pemoline (Cylert) 0.01 .4.8 0.04 .40 10 .0.5 .9 10 .50 1.051 0.240 0.0007 .0.007 .1 61 Plendil (Felodipine) 0.88 0.14 8 .0.5 >15 Parathion ***** ***** ***** ***** 0.2 2.06 .00300 0.0.0.1 .00015-0.062 ***** ***** 0.0002 0.70 .030 0.09 .09 0.0 ***** ***** ***** ***** Para-Methoxyamphetamine (PMA) ***** ***** ***** ***** 0.2 .0.0.3 22 .4 .0.0031 .22 .35 Phosphorus (Adult) 2.0.0088 0.51 ***** ***** 0.2 .0015 .1 .019 .0003 .16 1.0210 0.0.0.6 Paxil (Paroxetine) 0.1 .400 >50 >500 Paramethadione (Paradione) 0.0004 .9 Paraquat ***** ***** 0.0.11 .010 0.07 .0.0 ***** ***** ***** ***** Paraldehyde 2.8.0240 0.Drug and Chemical Blood Level Data .0 16 .085 .6 Papaverine 0.01 .0.003 .2 .6 >46 Pentazocine (Talwin) 0.4.1.2 .0.16.6 .0.4 4 .6 Phenylbutazone (Butazolidin) 1.0300 0.0019 .15 Page 12 .7 .02 .0 ***** ***** Perphenazine (Trilafon) 0.0007 .1.4.0.009 .0.022 0.031 .213 Plaquenil (Hydroxychloroquine) 0.5 2.15 .0099 0.0.0062 0.0 >3 >30 ***** ***** Phencyclidine (PCP) ***** ***** 0.22 ***** ***** 0.3.7 2-7 ***** ***** ***** ***** Pondimin (Fenfluramine) 0.001 .02 .02 .0.7 >7 1 .11 .0 Pepcid (Famotidine) 0.5.25 .40 200 .24 ***** ***** ***** ***** Phenelzine (Nardil) 0.4 .169 Pentothal (Thiopental) 0.003 .0001 .0062 0.0.85 .05 .004 .025 .0031 .22 ***** ***** 0.2 20 .0.0.5 6 .003 .3.0.2 1 .5 2-5 >0.50 1.2 ***** ***** ***** ***** Pentachlorophenol ***** ***** ***** ***** >4.0.062 ***** ***** 0.20 2-5 20 -50 >10 >100 Phisohex (Hexachlorophene) 0. Diphenylhydantoin) 1-2 10 .0006 .6 .5 Phenergan (Promethazine) 0.048 0.1 .0.0.1 .2 .0.0.0 .32 0.34 1.650 ***** ***** 0.0.07 .0.03 ***** ***** ***** ***** Phenylpropanolamine 0.15.100 0.099 ***** ***** 0.00 0.24 ***** ***** 0.210 ***** ***** 6.3 1-3 >0.3.33.0.0.34 1.00 0.0.0.0.16 1.00088 0.03 .40 4-6 40 .009 .001 .48 ***** ***** ***** ***** Phosphorus (Child) 4-7 40 -70 ***** ***** ***** ***** Piroxicam (Feldene) 0.002 .006 .1 1 ***** ***** Phenacetin 0.0.1 .0 Parnate (Tranylcypromine) 0.005 0.05 .9 0.035 ***** ***** ***** ***** Percodan (Oxycodone) 0.0.76 1.48 ***** ***** >1 >10 Phenytoin (Dilantin.10 0.1 .4 4 Phenobarbital 1-4 10 .2 >1.8 ***** ***** 2.00 ***** ***** ***** ***** Paradione (Paramethadione) 0.7.0.4.24 .0.1.0 .2.240 0.6 ***** ***** >0.0.8 20 .5 >5 1.15 80 .0240 0.0.015 ***** ***** PMA (Para-Methoxyamphetamine) ***** ***** ***** ***** 0.400 Pentoxifylline (Trental) 0.09 .03 .0.1.01 .6.09 .15 >1.022 0.5.0007 .004 .40 0.06 .2001 Therapeutic or Normal DRUG mg% Toxic ug/ml mg% Lethal ug/ml mg% ug/ml P Pancuronium (Pavulon) 0.5 1-5 Phendimetrazine 0.3 Pentobarbital (Nembutal) 0.03 >0.42 >0.00 ***** ***** ***** ***** Placidyl (Ethchlorvynol) 0.002 ***** ***** >0.0.150 ***** ***** Phentermine (Ionamin) 0.031 .0.150 20 200 40 400 Phenylephrine (Neo-Synephrine) 0.6 .16 0.0.0.1.024 0.007 .21.04 .3.12 Phenmetrazine 0.3 PCP (Phencyclidine) ***** ***** 0.0.8.5 .60 >8 >80 Phenol ***** ***** ***** ***** >4.14 .4 .0.024 0.0.50 0.0.20.49 0.009 .0035 0.006 .0.0.6 >6.00004-0.34.332 20 .0.400 0.2 .05 ***** ***** ***** ***** Paroxetine (Paxil) 0.14 .6 >46 Phensuximide (Milontin) 0.2 .007 .49 0.3 0. 4 .0.7 1-17 Propoxyphene (Darvon) 0.6 .04 .0632 0.Drug and Chemical Blood Level Data .0031 0.20.2 .008 .420 ***** ***** 0.1 >1 Prozac (Fluoxetine) 0.8 4-8 1 10 >2 >20 Procaine (Novocaine) 0.0.0072 .018 0.77 ***** ***** 1.0.371 1.1.0042 .04 ***** ***** ***** ***** Preludin (Phenmetrazine) 0.63 ***** ***** ***** ***** Prolixin (Fluphenazine) 0.8 Pseudoephedrine (Sudafed) 0.2 .0005 .0 1-3 10 .24 ***** ***** 0.0.031 ***** ***** ***** ***** Prothiaden (Dothiepin) 0.0170 ***** ***** ***** ***** Prograf (Tacrolimus) 0.17 .0.0 mg% 1.5 5 Procyclidine (Kemadrin) 0.07 .1.02 .3 .2.4.004 .0.063 0.034 0.1.3 .023 .04 .8 .75 ***** ***** ***** ***** Remeron (Mirtazapine) 0.1 .006 0.69 ***** ***** ***** ***** Page 13 .6 2 .3 2-3 Prosom (Estazolam) 0.12 Pronestyl (Procainamide) 0.2 .1.015 .0.1.8 11 .125 1.8 4-8 1 10 >2 >20 Propafenone (Rythmol) 0.12 0.007 .1.0009 .0.072 .8.0.8 .14.002 .1 .5 >5 Promethazine (Phenergan) 0.110 mg% ***** ug/ml ***** Prazepam (Centrax) 0.2 .107 0.0006 .0.148 ***** ***** ***** ***** Quetiapine (Serognel) 0.0100 0.0.0420 0.632 1.1.0.0.40 ***** ***** 0.0.4 4 Prilocaine (Citanest) 0.024 0.1 6 .0082 0.23 .6 0.005 0.50 .08 .039 .0094 0.27 .6.195 .47 [+met: Norpropoxyphene Propranolol (Inderal) 0.2001 Therapeutic or Normal DRUG Ponstel (Mefenamic Acid) mg% 0.077 0.00009-0.0015 .2 8 .003 .00170 0.20 0.0162 0.30 0.71 0.0.0.1 .1 >1 0.6 0.30 >0.0.042 .069 0.0.0.004 .3 .7 2-7 ***** ***** ***** ***** Repoise (Butaperazine) 0.5 >5 Quazepam 1.0.0.107 0.97 1.18 ***** ***** ***** ***** Remifentanil (Ultiva) 0.075 0.0.2 12 R Rantidine (Zantac) 0.01 ***** ***** 0.3 .0.0.0 >2.00 Toxic ug/ml 0.7 .0 >0.03 .50 Quinine 0.200 ***** ***** ***** ***** Procainamide (Pronestyl) 0.3 .100 0.05 .0.0.03 .0.80 0.12 Propylhexedrine (Benzedrex) 0.01 .5 .2 2.1 .0.80 10 100 Prinivil (Lisinopril.13 .0.0.009 .7 2.20 100 .3 13 ***** ***** Quinidine 0.0.13.165 0.0.0.002 0.1.04 .0003 .9 2 .0 Lethal ug/ml 11 .1 .28 .02 .0.24 .0039 .4 .07 0.0.7 1-17 Propoxyphene (Darvon) 0.1.5 1-5 ***** ***** ***** ***** Primidone (Mysoline) 0.0.03 .2.23 . Nifedipine) 0.4 .3.68 1.03 ***** ***** Promazine (Sparine) ***** ***** >0.711 ***** ***** ***** ***** Propylene Glycol 0.25 ***** ***** Prostep (transdermal) (Nicotine) 0.005 .0176 .34 0.11.19 5-8 50 .60 1-6 1 10 3-5 30 .0017 .1.0.004 0.06 0.0.099 ***** ***** 0.0.10 .06 ***** ***** 1 10 Pyridostigmine (Mestinon) 40 400 ***** ***** ***** ***** Q Quaalude (Methaqualone) 0.104 .0.16 ***** ***** ***** ***** Propofal (Diprivan) 0.0.050 .2 2 0.040 0.0.65 ***** ***** ***** ***** Proparacaine (Alcaine) 0.71.1.017 .0.002 .2 .7 .7 >1 >10 1.25 0.0.0.9 19 Pyribenzamine (Tripelennamine) 0.07 0.06 0.1 >1 >0.2.038 0.1 >21 ***** ***** Procardia (Adalat.5 Protriptyline (Vivactil) 0.001 0.0.0036 .02 >0.0.2 2.0.162 ***** ***** ***** ***** Prochlorperazine (Compazine) ***** ***** >0.0.003 >0.17 .01 .023 .03 .0. Zestril) 0.0.0.0.0.0195 .0099 0.001 .0.05 ***** ***** ***** ***** Renese (Polythiazide) 0.006 .094 ***** ***** ***** ***** Reglan (Metaclopramide) 0.9.1 .09 .0.38 0.082 Probenecid (Benemid) 10 .4 .02 .0.0.0.0.0004 .036 . 52 Sectral (Acebutolol) 0.for normal usage] Salicylate [met: Acetylsalicylic Acid-for rheumatoid arthritis] Sandimmune (Cyclosporine) 0.0.003 .099 0.1 .1.0 ***** ***** 4 40 Salicylate 2 .52 Seconal(Secobarbital) 0.4 .1 .0009 .0.25 >0. Mazicon) 0.0.0.1.050 .2.076 ***** ***** ***** ***** Robitussin (Guaifenesin) 0.12 0.0003 .2 ***** ***** ***** ***** Sildenafil (Viagra) 0.055 .1.2.0055 .1 .032 0.23 2.34 13.Drug and Chemical Blood Level Data .0012 0.009 .40 >0.6 13 .3 .26 1.0423 0.22 1 .0.0.1.0.40 3-5 30 .3 .1 >1 >0.6 .189 1.26 Saquinavir (Invirase.0027 .0003 .001 .019 ***** ***** 0.2 >0.0039 0.0.027 .010 .5.165 0.3 13 ***** ***** Sertraline (Zoloft) 0.2 .00017 0.0003 .09 Toxic ug/ml 0.990 ***** ***** ***** ***** Ritalin (Methylphenidate) 0.52 ***** ***** 0.25 0.18 .3.0.2 >0.011 .06 .08 0.133 .195 .0.0.16 .66.1 .0.0019 0.5.22 1 .003 .4 21 210 ***** ***** Rofecoxib (Vioxx) 0.7 .0.0632 0.5 >5 Stadol (Butorphanol) 0.0.006 0.0.1 26 .1 .2001 Therapeutic or Normal DRUG Restoril (Temazepam ) mg% 0.012 .00027-0.65 ***** ***** ***** ***** S Salicylamide 0.8 3-8 ***** ***** ***** ***** Soma (Carisoprodol) 1-4 10 .045 0.4 ***** ***** ***** ***** Serognel (Quetiapine) 0.43 0.0011 .050 .019 ***** ***** ***** ***** Serax (Oxazepam) 0.0.0.8 .0.01 .12 .27 .12 0.05 ***** ***** Romazicon (Flumazenil. Fortovase) 0.0.0.10 .2.0.0.0.5 .25 ***** ***** ***** ***** Serzone (Nefazodone) 0.3 Ritonavir (Norvir) 1.0012 0.8 0.0.012 ***** ***** ***** ***** 9-Hydroxy Risperidone 0.05 >0.0.045 ***** ***** ***** ***** Sandoptal (Butalbital) 0.0076 0.0.0.001 .352 1.0127 .41 ***** ***** ***** ***** Robinul (Glycopyrrolate) 0.3 0.005 .0.3.0006 .7 .4.0.50 11 110 Sparine (Promazine) ***** ***** >0.01 .34 13.016 .0.14 0.300 50 500 2 .0.5 .0 ***** ***** ***** ***** Robaxin (Methocarbamol) 2.115 0.40 1.0.100 15 .5 5.6 0.0133 .3 >3 0.4 ***** ***** ***** ***** Serofrane (Seroflurane) 1.11 .17 .015 .0.0.3 1-3 ***** ***** ***** ***** Risperdal (Risperidone) 0.30 150 .8 ***** ***** ***** ***** Rezulin (Troglitazone) 0.06 0.08 0.11 0.0019 0.01 .89 Secobarbital (Seconal) 0.1.0.15 .0056 ***** ***** ***** ***** Sinequan (Doxepin) 0.15 ***** ***** ***** ***** Simvastatin (Zocor) 0.2.140 0.006 .3 >3 0.0.10 20 .6 11.118 .00003 .32 ***** ***** ***** ***** Rohypnol (Flunitrazepam) 0.0052 0.423 ***** ***** ***** ***** Selegine (Eldepryl) 0.0.2 .0.0.0017 ***** ***** ***** ***** Page 14 .025 0.0.4 .3 3 Seroflurane (Serofrane) 1.632 1.35 [+met: N-Desmethyldoxepin] Skelaxin (Metaxalone) 29.2 5 .005 0.0.025 0.25 20 .025 0.00056 0.052 0.04 .10 .2.012 ***** ***** ***** ***** Risperidone (Risperdal) 0.17 .0.1 ***** ***** ***** ***** Scopolamine (Hyoscine) 0.5 0.0195 .0.0.0.4.0.0.05 .6 2 -26 Sinequan (Doxepin) 0.0.006 .4 7 .0.0.00011-0.9 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** Retrovir (AZT.250 ***** ***** ***** ***** [met: Acetylsalicylic Acid .127 .2 ***** ***** ***** ***** Seldane (Terfenadine) [as active metabolite] 0.6 296 ***** ***** ***** ***** Sodium Aurothiomalate (Gold) 0.0176 .5 .039 ***** ***** ***** ***** Rythomol (Propafenone) 0.005 .0.6.1.5 8 .2 5 .2 >2 ***** ***** Serentil (Mesoridazine) 0. Zidovadine) 0.1.04 .0.010 . 08 0.2 1.007 .100 0.8 T Tacrolimus (Prograf) 0.4 .20 Toxic ug/ml 0.1.6 .019 <0.031 0.0133 .12 >1.019 <0.15 100 .29 >10 >100 20 200 Thiopental (Pentothal) 0.105 0.4 .133 .3 .0.01 .42 >0.1 .03 ***** ***** Tagamet (Cimetidine) 0.5 0.28 .15 0.0 Sublimaze (Fentanyl) 0.25 50 .19 ***** ***** ***** ***** Theophylline (Aminophylline) 1-2 10 .4.08 >0.03 .001 .0 mg% 0.0.12 Tiagabine (Gabitrol) 0.21 .0.001 .6 >0.8 ***** ***** Tegretol (Carbamazepine) 0.8.004 .0.0.05 .0.05 .12 .23 ***** ***** ***** ***** Tin 0.3 Tambocar (Flecainide) 0.0006 0.50 ***** ***** ***** ***** Sulfanilamide 10 .10 ***** ***** ***** ***** Sudafed (Pseudoephedrine) 0.0002 .10 ***** ***** ***** ***** Tofranil (Imipramine) 0.8 ***** ***** ***** ***** Tocainide (Tonocard) 0.011 ***** ***** ***** ***** Sulfadiazine 8 .2.48 2.1.0.8 .5 ***** ***** ***** ***** Talwin (Pentazocine) 0.7.44.0.70 3.010 0.0.5 .002 .0.02 .2 1 .118 ***** ***** ***** ***** Taractan (Chlorprothixene) 0.0.11.234 ***** ***** ***** ***** Tigan (Trimethobenzamide) 0.0.04 .024 .2.0.400 Thioridazine (Mellaril) 0.12.04 Terfenadine (Seldane) [as active metabolite] 0.4.0007 .0 mg% 0.45 0.001 .1.0 Symmetrel (Amantadine) 0.2 3 .29 ***** ***** ***** ***** Thiocyanate [met: Nitroprusside] 0.0.85 2.0.0024 .1 .0.0001 .0.0 ***** ***** ***** ***** [+met: Mesoridazine] Thiothixene (Navane) 0.150 ***** ***** ***** ***** Sulfisoxazole 9 .011 ***** ***** ***** ***** Sufentanil (Sufenta) 0.150 ***** ***** ***** ***** Sulfaguanidine 3-5 30 .0.002 0.100 ***** ***** ***** ***** Sulindac (Clinoril) 0.0.3 .07 0.8 ug/ml 3-8 Strychnine ***** ***** 0.5 0.9 ***** ***** ***** ***** Tenormin (Atenolol) 0.26 0.05 .0.0.16 .0.0200 0.0001 .005 .05 1 .0.4.077 0.0.423 ***** ***** ***** ***** Tetrachloroethylene ***** ***** ***** ***** 0.0423 0.2.87 .001 .1 .5 Page 15 .050 0.004 .8 1 -18 Thioridazine (Mellaril) 0.5 2-5 >0.0 THC (Tetrahydrocannabinol) <0.5 .012 .1.0234 0.0.2 1-2 0.0.03 .50 .4 .095 ***** ***** ***** ***** Surmontil (Trimipramine) 0.0.010 0.01 .0.78 1.10 0.20 2.8 .001 .2 2 0.0.10 90 .0.015 .0011 0.00 0.77 ***** ***** 1.0005 .2 1-2 ***** ***** ***** ***** Timolol (Blocadren) 0.31 0.0.54 5.0.0.5 .15 80 .0.1.023 0.4 .0.19 ***** ***** ***** ***** Thallium <0.10 ***** ***** ***** ***** Thorazine (Chlorpromazine) 0.14 .15 .0.200 ***** ***** 0.004 0.1 .02 .2001 Therapeutic or Normal DRUG Stelazine (Trifluoperazine) mg% 0.09 0.3 .01 .0.006 .1 .0.0.Drug and Chemical Blood Level Data .5 .40 0.01 .2 .1.0001 .0.10 0.20 .55 .006 ***** ***** 0.0.0.05 .0.1.2.04 .1.0.0.0.0.5 4-5 ***** ***** ***** ***** Sumatriptan (Imitrex) 0.04 .9 6 .28 .0.0.4.03 >0.5 .40 5 .0.0.0.050 .7 >7 1 .2 .30 0.12 .0.4.1 .5 .250 Thiocyanate 0.9 5.50 0.0 ***** ***** ***** ***** Tandearil (Oxyphenbutazone) 1.1.06 .003 .0.001 .001 .0 4.6 .02 >0.5 35 ***** ***** Tenuate (Diethylpropion) 0.030 0.1 .0.2 .1.04 .0 4 .0.0.1 .0.12.0.7 .008 <0.20 8.45 .8 11 .030 0.30 Lethal ug/ml 1.9 19 Sufenta (Sufentanil) 0.01 .0011 0.4 .014 0.0 Tetrahydrocannabinol (THC) <0.20 3-4 30 .5 >15 >5 >50 Temazepam (Restoril) 0.30 ***** ***** 0.3.003 >0.0.1 >1 0.0095 0.40 10 .14 ***** ***** ***** ***** Tobramycin (Nebcin) 0.0105 0.11.5 >5 0.4 Terbutaline (Brethine) 0. 6 >6.1 .0069 .07 .3.3 .200 Valproic Acid (Depakene) 5 .0.0.2 0.12 10 100 25 250 0.00 ***** ***** ***** ***** Tylenol (Acetaminophen) 1-2 10 .31 .02 .2001 Therapeutic or Normal DRUG Tofranil (Imipramine) [+met: Desipramine] mg% 0.070 ***** ***** ***** ***** Venlafaxine (Effexor) 0.0063 .30 ***** ***** ***** ***** Trimethobenzamide (Tigan) 0.00 0.0.4.069 .2 2 .40 ***** ***** ***** ***** Vasotec (Enalapril) 0.1.6 43 .200 ***** ***** Vancomycin 3-4 30 .0004 .5 ***** ***** ***** ***** Tramadol (Ultram) 0.00300 0.0.4.5 .0.2.06 ***** ***** 1 10 Triprolidine (Actidil) 0.0 1 .01 .05 .96 ***** ***** 64 640 Tolectin (Tolmetin) 3.7 .9.05 ***** ***** ***** ***** Ultram (Tramadol) 0.5 15 Trental (Pentoxifylline) 0.007 .1.5 >5.6 Trancopal (Chlormezanone) 0.0.002 .04 .01 .0.4.0.1 .06 .8.0300 0.0.1 .138 ***** ***** 0.7 .271 ***** ***** ***** ***** Tranxene (Chlorazepate) 0.90 ***** ***** 0.0.4 .0 Triazolam (Halcion) 0.0.15 .0.01 .0.0.Drug and Chemical Blood Level Data .1.0 0.93 ***** ***** ***** ***** Page 16 .87 .6.393 0.1 .001 .004 .20 0.8 3-8 Trilafon (Perphenazine) 0.1.11.0004 .1.0 0.2.400 0.0.489 0.1000 Trichloroethanol 0.0.002 0.0.0.0.30 ***** ***** 0.110 [met: Chloral Hydrate (Noctec)] Trichloroethylene Tridione (Trimethadione) 1-3 10 .2 1-2 ***** ***** ***** ***** Trimethoprim (Trimpex) 0.087 .0.4 >34 [+met: N-Desmethyldiazepam Valmid (Ethinamate) 0.00004-0.07 .3 .005 0.0.12 .0.01 .7 37 >6 >60 ***** ***** Toluene ***** ***** ***** ***** 1 10 Tonocard (Tocainide) 0.71 .1.00 ***** ***** >3.7 37 >6 >60 ***** ***** Tolmetin (Tolectin) 3.005 0.3 .16 0.015 .0.0.5 .6 >0.1 .030 0.45 0.100 0.0.025 Toxic ug/ml 0.06 0.006 .20 100 .0.89 ***** ***** 1.1 .0 4 .100 100 .12 Uric Acid 3-7 30 .007 0.10 ***** ***** ***** ***** Toradol (Ketorolac) 0.87 .2 .25 .20 8.12.0.0 ***** ***** [as met: N-Desmethyldiazepam Tranylcypromine (Parnate) 0.9.7 .1 1 ***** ***** Trimethadione (Tridione) 1-3 10 .0044 0.600 0.0.6 ***** ***** >0.0 Trimpex (Trimethoprim) 0.02 ***** ***** ***** ***** Tribromoethanol ***** ***** ***** ***** 9 90 Trichloroethane ***** ***** ***** ***** 10 .00063 .20 15 150 >16 >160 Ultiva (Remifentanil) 0.6.0.1 .20 >3 >30 Valium (Diazepam) 0.0036 .0003 .2 1-2 ***** ***** ***** ***** Trimipramine (Surmontil) 0.5 .0.2 1-2 ***** ***** ***** ***** Tripelennamine (Pyribenzamine) 0.0271 0.044 ***** ***** ***** ***** Tubocurarine 0.0.8 ***** ***** ***** ***** Trandate ( Labetalol.004 .0.1 .031 .30 ***** ***** ***** ***** Trifluoperazine (Stelazine) 0.88 2.1.006 0.0 7.0 3 .3.0.0138 0.20.036 .0 5 .06 0.0.70 ***** ***** ***** ***** U V Valium (Diazepam) 0.2 .4 .11 ***** ***** 10 .600 0.05 ***** ***** ***** ***** Trazodone (Desyrel) 0.07 .10 50 . Normodyne) 0.003 .25 mg% ***** Lethal ug/ml ***** mg% ***** ug/ml ***** Tolbutamide (Orinase) 4.16 0.30 1.6 Unisom ( Doxylamine) 0.1 4 . 0.0.272 ***** ***** 0.2 0.0.08 1.0.022 .007 .2 0.0009 .0 >0.5 .0022 .100 ***** ***** 25 250 Zestril (Lisinopril.046 .016 .0.15 .0055 .0.07 .9 4.032 0.046 .112 0.0.018 ***** ***** ***** ***** Zomig (Zolmitriptan) 0.0094 0.075 .1 >1 Vistaril (Atarax.025 0.2001 Therapeutic or Normal DRUG [met: O-Desmethylvenlafaxine] mg% 0. Prinivil) 0.112 0.0122 .0.3 13 3.5 >25 Y Yocon (Yohimbine) 0.0055 .0. 0 .0.0.0.20 0.10 40 .008 0.0.68 .0022 .0025 .0. Hydroxyzine.025 0.36 ***** ***** ***** ***** Zocor (Simvastatin) 0.10 .009 .0.075 Toxic ug/ml 0.0.0.003 .0.0046 .390 X Xanax (Alprazolam) Xylene ***** ***** ***** ***** 0.0.0.0355 0.0.0.036 .0.3.114 ***** ***** ***** ***** Zolmitriptan (Zomig) 0.75 .39 Vistazine (Hydroxyzine) 0.5 .0.0.0272 0.3.25 ***** ***** ***** ***** Viagra (Sildenafil) 0.022 .3 3 .3.127 .1.2 0.0.09 .1.272 ***** ***** 0.12 Zoxazolamine (Flexin) 0.0046 .0.0.0027 .) 0.0.08 0.025 .2.102 ***** ***** 0.5.1.04 .0.25 ***** ***** ***** ***** Zolpidem (Ambien) 0.03 .2 Page 17 .0.3 0.08 ***** ***** 0.5 .8 ***** ***** ***** ***** Zilenton (Zyflo) 0.4 .0.31 0.0003 .0.1.12 1.1.0.05 .00027-0.027 . Retrovir) 0.0.73 7.5 .32 ***** ***** ***** ***** Vivactil (Protriptyline) 0.08 .2 7 .00056 0.0.0.8.122 .115 0.0 0.290 ***** ***** ***** ***** Z Zantac (Rantidine) 0.3 .0.0.0.85 Versed (Midazolam) 0.9 0.2 .20 >2.9 .2.029 0.055 .04 .023 ***** ***** 0.029 .0056 ***** ***** ***** ***** Zofran (Ondansetron) 0.02 . Lortab) 0.05 .0.0.4 .0.029 0.16 .0.11.0.7 .15 Lethal ug/ml 1 .27 .355 0.008 .094 ***** ***** ***** ***** Zarontin (Ethosuximide) 4 .025 .50 1.0036 .5 mg% ***** ug/ml ***** Verapamil (Calan.038 0.1 .13 ***** ***** ***** ***** Zyflo (Zilenton) 0.75 mg% 0.008 0.061 .002 .0.0.068 .3 .025 0.31 1.31 0.6 6 ***** ***** W Warfarin (Coumadin) 0.07 .290 ***** ***** ***** ***** Yohimbine (Yocon) 0.7 .1 ***** ***** ***** ***** Zinc 0.055 .15 Vicodin (Hydrocodone.0102 0.Drug and Chemical Blood Level Data .3.0 0.0025 .082 Zidovadine (AZT.4 .100 ***** ***** 0.0100 0.0.039 0. Cataflam) 0.0127 .003 .0.0.38 0.0272 0.0029 .5 0.0.25 0.029 .1.0023 0.1 ***** ***** ***** ***** Zyprexa (Olanzapine) 0.12 Zoloft (Sertraline) 0.20 0.5 .05 .0029 .1.0.0018 0.110 Xylocaine (Lidocaine) 0.0114 0.0082 0.0.9 39 Voltaren (Diclofenac.0.12 Vioxx (Rofecoxib) 0.09 0.1 ***** ***** ***** ***** Wellbutrin (Bupropion) 0.05 . Isoptin) 0.0 3 .0.136 0.0061 . 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