Graphical AbstractTo create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Leave this area blank for abstract info. If you click this button. City and Postal Code. select the template. you see a number of buttons that activate drop-down menus. and Given-name Surname 3b a b ∗ Affiliation 1. 3. 2. the template will automatically switch to normal paragraph style. When you hit the Enter key. Note Please read these instructions carefully. in authoring your paper. a new document containing the instruction text will be created. Introduction We at Elsevier believe a template should help you. City and Postal Code. but naturally you can adjust all that using the menu options. but do not change or redefine them in any way as this will lead to unpredictable results. you will automatically be in the affiliation style. however. (Note that the button may not work properly if you change in any way this text. only capitalize first word Given-name Surname 1a . bother about alignment.: +0-000-000-0000. It should be emphasized.edu . Save the document. you finish a paragraph.doc) in Word® is a “mold” that formats documents based on it. All rights reserved. after the style for authors’ names. that the final appearance of your paper in print and in electronic media will very likely vary to greater or lesser extent from the presentation achieved in this Word® document.g. After a section heading. e l s e v ie r . do not worry. Country ARTICLE INFO Article history: Received Received in revised form Accepted Available online Keywords: Keyword_1 Keyword_2 Keyword_3 Keyword_4 Keyword_5 ABSTRACT Type your Abstract text here 2009 Elsevier Ltd. Organisation of the template A template (with its file name ending on . which you can save in your hard disk for reference. rather than on . 1. choose the Create New Document option. To create a new document. The objective of this template is to enable you in an easy way to style your article attractively in a style similar to that of Tetrahedron. not hinder you. the instructions will be removed and the document can be used for your text. you will not need to remember shortcut keys. Styles define the format (or appearance) of a paragraph of text as regards letter size.j o u r n a l h o me p a g e : w w w . Use the styles.) Also. To use the Tetrahedron template you should first save it with the other templates. co m Tetrahedron Click and type the title of your paper. A ‘Styles’ menu is available in the customized ‘Els_Tools’ bar for applying Styles to paragraphs. fax: +0-000-000-0000. not force you to fill in bits and pieces of text. To do this. e. It should allow you to type any text.1. the text between two subsequent hard returns (¶). the Title Page styles are Corresponding author. indents. indentation. If you’re not familiar with using styles.dot. and double-click on the template icon. In the ‘Styles’ menu. Given-name Surname 2a. line spacing. the template arranges everything for you in a user-friendly way. choose the ‘General’ tab and paste the template there. i. e-mail: author@university. It should follow you in how you want to write your paper. Address. to use lists of styles. etc. Just a mouse-click at one of the menu options will give you the style that you want. fonts and point sizes as defined in this template. You will therefore find no fill-in screens. The toolbar and its menus At the top of the working area. click on ‘New’ on the ‘File’ menu. Country Affiliation 2. You can select the required styles from these menus. The template chooses at that moment the most appropriate next style. or load an already existing plain text to be formatted.e. At the end of the instructions you will find a button. 3. copy from previous versions. The template formats your text by using a Word ® feature called ‘Styles’. what you see and open are in fact templates. Tel. Address. If you click ‘New’ on the ‘File’ menu. fonts and point sizes. The reason is that the Abstract should be understandable in itself to be suitable for storage in textual information retrieval systems. Choose from the ‘Tools’ menu the option ‘Templates and Add-Ins…’. (3) Conclusion. In that case take care to retain or re-insert the above mentioned section breaks. The Abstract An Abstract is required for every paper. 5. and the ‘Insert Figure’ option can be used to browse to a chosen directory in your hard disk and insert figures in the desired position. Do not use abbreviations in it. list all authors with their first names or initials and surnames (in that order).g. Word® uses those to separate the one-column and two-column parts. Next. References) and reference entries styles are under ‘Tail’.) From the Word® ‘File’ → ‘Page Setup’ menu. You may also attach the template to an already existing document. Very often you will already have prepared (parts of) your text. Do not include artwork. and trademark protection should be acknowledged in the standard fashion. you should pay attention to the ‘section breaks’ in it. (You may find working in ‘Normal’ view more convenient anyway. If you remove text to replace it with your own text. Supply some 3–8 keywords. you can create equations in the Word® equation editor. insert the appropriate break (page break or column break) from the Word® menu to restore it. and all nonstandard abbreviations should be defined on first usage. . You can apply the appropriate styles from the ‘Els_Tools’ Styles menu to obtain the Tetrahedron layout. while containing all the information necessary to guarantee reproducibility. Alternatively.1. After the file is inserted you can style it by placing the cursor in each paragraph and clicking the required style on the drop-down menus. Ensure that all tables. as well as to serve as page breaks. (4) Experimental Section and (5) References. Switch to a 2-column lay-out after the Abstract. tables. the main findings.listed under ‘Head’.and twocolumn settings. In case the lay-out becomes disrupted. 4. e. Supplementary data and other sections are optional. The first way is to simply type your text in a blank document based on this template. You will usually want to divide your article into (numbered) sections and subsections (perhaps even subsubsections). The ‘Insert Table’ option can be used to insert tables. 4. for a section heading. you may insert the whole text or parts you previously prepared by using on the ‘Insert’ menu of Word ® the option ‘File…’. The experimental information should be as concise as possible. Switch to ‘Normal view’ on the ‘View’ menu to see the breaks. Link authors and affiliations using superscript lower case letters from the ‘Author Footnote Symbols’ menu in the toolbar. it should succinctly summarize the reason for the work. Unnumbered headings (e. The main text The paper must include the following: (1) Introduction. in the MathType™ equation editor. Using the ‘Insert Equation’ option. you can easily insert it into a document based on this template by cutting and pasting between the two documents. After having listed all authors’ names. separated with semicolons. Acknowledgements. so you will need to reinsert those. using the superscripted characters for trademarks and registered trademarks respectively. Note that text runs on after a 4th order heading. using the options in Microsoft Word® to adjust column settings. Using those options will remove the one. The ‘Tools’ menu in the Els_Tools bar does more than just apply a style. you should list their respective affiliations. Switching to ‘Page’ view will restore the two-column lay-out once you have finished. At the end of your text. You may in this case have to adjust the margins of the document using the Page Setup options on the ‘File’ menu. Code section headings using the options in the ‘Styles’ menu. greek symbols. choose the appropriate style from the dropdown custom menus. Trade names should have an initial capital letter. (2) Results/Discussion. while the cursor is somewhere within the paragraph. and some common math and chemistry symbols. elaborate equations or references to other parts of the paper or to the reference listing at the end. your paper should start with a concise and informative title. If you load that text as a separate document. balance the columns using the ‘Continuous’ option from the ‘Insert’ → ‘Break’ menu. you can adjust the typing area to the paper size (A4 or Letter size paper) that you use. The first page Naturally. Insert a switch to one column before any page-wide tables. figures and schemes are cited in the text in numerical order. Headings should reflect the relative importance of the sections.g. If you want to apply a different style. It has palettes to insert author footnote symbols. start typing the text first as a new paragraph and. The abstract should be no longer than 100 words. Abbreviations should be used consistently throughout the text. and the main text styles are under ‘Body’. or if the MathType™ equation editor is installed on your computer. Indicate the author for correspondence using the ‘Tools’ menu. Present addresses can be inserted as Word® footnotes using the ‘Insert’ → ‘Footnote’ menu. and the conclusions of the study. or other internationally accepted units. Entering text There are several ways in which you can enter and format your text in this template. Select the ‘Tetrahedron’ template and make sure to tick the box ‘Automatically update document styles’ to make the styles available. 3. Use the heading style for the whole paragraph. but remove the italic coding except for the actual heading..2. All measurements and data should be given in SI units where possible. Authors are requested to draw attention to hazardous materials or procedures by adding the word CAUTION followed by a brief descriptive phrase and literature references if appropriate. choose ‘Format object’.01 equiv). please take a look at our Web page: http://www.04 equiv). 3. Peptidyl and peptidomimetic P1-argininal derivatives 2a-t produced via Scheme 1 7 1. and click the ‘View’ tab. Graphs may appear either on a fixed spot in the text.3. rather than link the object.g.0 equiv 3.3 11. In that case you may choose to place all artwork at the end of the text and insert a marker in the text at the desired place. a paragraph it is linked to.0 equiv 3. and moves with. volume. choose the ‘Wrapping’ tab and select ‘Top & bottom’. -20°C TMSOTf (0. right-click the graph. Scale your artwork in your graphics program before incorporating it in your text. etc. TIFF or EPS). in mathematical equations. special equipment.0 Yield % 72 89 88 95 The reaction was conducted in anoxic conditions. If the artwork turns out to be too large or too small. a figure will always be floating. ‘Options…’. a chemical structure. The text should not run along the sides of any figure.e. sources of less common starting materials. You can move the figure itself by dragging but you can also drag the anchor. which remains in the same place on the page regardless of the text flowing around it. You can insert a caption below the figure or scheme. Figures. resize it again in your graphics program and re-import it or use the sizing handles at the corner of the artwork. b 5.1.com/locate/authorartwork.. You can type your equations and use the symbols in the Word® equation editor or in MathType™. If grouped with a caption. toluene. essentially the same. • • The first entry in this list The second entry 2. variables and anything that represents a value appear in italics.elsevier. You might find positioning your artwork within the text difficult anyway.01 equiv). The Experimental section must contain all the information necessary to guarantee reproducibility. Schemes. so you can share information through linked and embedded objects.. e. separate files in standard format (i. Depending on the amount of detail. You may choose to number equations for easy referencing. and Tables should be numbered. Equations Conventionally. not included in the Word® text document. mmol. 2. Et2O. To choose between the two options. submitted as † OLE: Object Linking and Embedding. For instance you can import an Excel® graph into Word® by using ‘Paste special…. except for positional prefixes. -20°C TfOH (0. lists are often used. Lists For tabular summations that do not deserve to be presented as a table.† Make sure you embed.1.1. Tables and figures Graphics and tables may be pasted directly into the template and positioned as they should appear in the final manuscript. Artwork can be inserted using the ‘Insert’ options in the ‘Tools’ menu or by embedding the graph as an OLE object. A subentry The last entry A bulleted list item Another one You can use the Bullets and Numbering options in the ‘Formatting’ toolbar of Word® to create lists. In that case the number should appear at the right margin. a program-integration technology you can use to share information between programs.388 Å) (theor. Note that you should first block the whole list.3 7. 5. should be provided. A small anchor symbol should indicate the paragraph to which it is linked. please keep in mind that the placement of artwork may vary somewhat in relation to the page lay-out. 5. Artwork is normally linked to. right-click the figure.0 equiv 3. This is the format for table footnotes. Below you see examples of both. select them both (hold down the <SHIFT> key and click both figure and caption) and choose. Tick the ‘Object anchors’ tick box. choose the ‘Position’ tab and tick or clear the ‘Float over text’ tick-box. Experimental section (1) Authors should be as concise as possible in experimental descriptions.388 Å) × ∇ (theor) cosθ 6. etc. ∇ = ∇ (empir. All of the Office programs support OLE. Lists may be either numbered or bulleted. choose ‘Format Object (/Figure)’.0 equiv a Conditions TfOH (0. using the option on the ‘Tables and figures’ menu. Grouping. An introductory paragraph containing information concerning solvents. choose from the ‘Tools’ menu. If you do not see the anchor. If it does. or ‘floating’. To keep the drawing and caption more easily together. This section need to include the type of elemental analyzer and the name of the analytical lab.1. -30°C Ratio α:β 1.’ on the ‘Edit’ menu or. In any case. under the right mouse button. Please remember that we will always also need highresolution versions of your artwork for printing. A sublisting is coded using the ‘Increase Indent’ (go to a sublevel of numbering) and ‘Decrease Indent’ (go to a higher level of numbering) buttons. normally a figure or scheme with a caption. for ease of discussion and reference in the text.2. in parentheses after the names of . 1. Before preparing your artwork.1 2.01 equiv). Structures in schemes should also be numbered consecutively.Table 1. The procedures should be written in the past tense and include the weight. -20°C TMSOTf (0. while chemical equations are displayed in roman. Et2O. toluene. you can choose to display artwork in one column (20 pica wide) or across the page (42 pica wide). CHOMe). Buchanan. Ling. [Found: C. if accompanied by suitable NMR criteria for sample homogeneity. CHaHbCH2OSi). found 333. subsequently.91 (1H. CHaHbCH2OSi).01 (3H. 1255.06–1. 1997).27 (1H. (2S. Abstr. DC. 64.9. Physical and spectroscopic data. C18H41O3Si requires 333. dC (100. Authors should ensure that all references are cited in the text and vice versa. 1470.83 (1H.5 shown in the References section. CHMe). 1996. 0. Supplementary Material Supplementary material that may be helpful in the review process should be prepared and provided as a separate electronic file.93 (3H.7. m/z (CI. 1995. 159 (100). F.2825. high-resolution mass analysis. John Wiley & Sons: New York. Z.3R. S. NH3) 333 (30. Lyle. 15.39%]. M.4-dimethyl-1-hexanol (23) A mixture of benzyl ether 22 (61. d. m. Ph. Rf (30% Et2O/CH2Cl2) 0. P. 1.3. CHMe).the substances or solvents.D. 1105 cm−1. Ed. 257 (25). Inclusive pagination is strongly recommended.1. R.0. H. 1. The title of an experiment should include the chemical name and compound number of the product prepared. Characterization of new compounds: All new compounds should be fully characterized with relevant spectroscopic data. dH (400 MHz CDC13) 3. Chem.. 2..0 mg. 32.2825. CHCl3). 1985.1. 3. A standard acceptable experimental format is appended below (for your reference): 6. m. CH2OH).6 MHz.5 Hz. 91%) as a colourless oil. J.12 g) in dry ethanol (2 mL) was stirred under a hydrogen atmosphere at room temperature for 6 h. 1. Chem. 61. 0. 34. 18. S. m. Dodd. 1972.79–3. In Selective Organic Transformations. S. Authors are expected to check the original source reference for accuracy. Use the unnumbered AcknowledgementsHead style for the Acknowledgments heading. Details of the workup procedure must be included.S. 4. Haslam. 12.0 Hz.6. before the references. . CHMe). J 4.46 (3H. 141 (50). 3.95 (1H.4. General reaction conditions should be given only once.2 books. Bibliography References and notes in the text should be indicated by superscript Arabic numerals that run consecutively through the paper and appear after any punctuation.. 1985. 61. which was purified by flash chromatography (30% Et2O/CH2Cl2) to give the title compound 23 (44. 11. m.79–3.4 mg.0. The reaction mixture was filtered through celite and the solvent evaporated in vacuo to give the crude product. not as a footnote to the title. Click here to remove instruction text. 1. 16. Dissertation.04 (18H. Journal titles should be abbreviated according to American Chemical Society guidelines (The ACS Style Guide. 60.: American Chemical Society: Washington. 2870. Microanalyses should be included whenever possible. 5. CHMe). 37. J. CH2OSi). 4.145 mmol) and 10% palladium on charcoal (0.5. J.43. Thyagarajan.97 (3H. Mariano. OMe). high-resolution mass spectra may serve in lieu of microanalysis. CDCl3) 92. Cornell University. B. 64. buried m. 0. 109 (37%). H.0 Hz.81. 65.1 theses. MH+). 2. this compound should be identified by its number. References and notes 1. B. m.3.91–1.81–1. R. Sable. s. 2.9 (c 2.. Under appropriate circumstances. K. 4439–4449.4 and patents. Org.3. Shikimic Acid Metabolism and Metabolites.35–1. 1..0. 12. 1390.56 (2H. G..9. including NMR. m. nmax (liquid film) 3600–3100 (br). 1993. Acknowledgments Acknowledgments should be inserted at the end of the paper. H. dd. HRMS (CI. J 7. Me2CHSi). That file can then be transformed into PDF format and submitted along with the manuscript and graphic files to the appropriate editorial office. See examples for journal articles. Goering. Ed. Me2CHSi). [a]D20-1. Patent 5 973 257. pp 1–95. NH3): MH+. 3. br d. can be included in the experimental section or presented in tables. Wiley-Interscience: New York.00–1.9. 66. Vol. d. E. and elemental analysis..0. J 7. Yoshida. C18H41O3Si requires C..2.56 (2H. J 7.73 (1H. U.0 Hz. 2.4R)-6-Triisopropylsilyloxy-2.