Annexure – I Scheme of Examination for eight semesters of B. Pharm. Course Name and number of heads of passing, number of papers, duration of examinations, maximum marks, and minimum marks for passing, periodic tests duration, maximum marks. First Year B. Pharm. (SemesterI) THEORY Duration Hours Duration (Hours) Min. for Passing Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Anat., Physio. & Patho. I 1 2 40 16 1 10 50 2 General Chemistry I 1 2 40 16 1 10 50 3 Organic Chemistry I 1 2 40 16 1 10 50 4 Physical Pharmacy I 1 2 40 16 1 10 50 5 Pharmaceutics I 1 2 40 16 1 10 50 6 Pharm. Engineering I 1 2 40 16 1 10 50 PRACTICALS 7 Organic Chemistry I Lab. 1 4 40 16 4 10 50 8 Physical Pharmacy I Lab. 1 4 40 16 4 10 50 9 Anat., Physi. & Path. I Lab. 1 4 40 16 4 10 50 * 1 hour tutorial either before or after the practical: However exam will be for 04 hours. Total Marks for the Semester 450 Minimum marks for passing the semester 225 No. Of Papers Entry 20 20 20 20 20 20 20 20 20 First Year B. Pharm. (SemesterII) THEORY Duration Hours Min. for Passing Duration (Hours) 1 1 1 1 1 1 4 4 4 4 Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Organic Chemistry II 1 2 Pharmaceutical Analysis I 1 3 Physical Pharmacy II 1 4 Pharmaceutics II 1 5 Microbiology 1 6 Anat., Physio. & Patho. II 1 PRACTICALS 7 Pharmaceutical Analysis I Lab. 1 8 Pharmaceutics I Lab. 1 9 Physical Pharmacy II Lab. 1 10 Microbiology Lab. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 4 4 4 4 40 40 40 40 40 40 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 40 16 500 250 1 | P a g e Second Year B. Pharm. (SemesterIII) THEORY Duration Hours Min. for Passing Duration (Hours) 1 1 1 1 1 1 1 4 4 4 Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Organic Chemistry III 1 2 Pharmaceutical Analysis II 1 3 Biochemistry I 1 4 Pharmaceutics III 1 5 Pharmaceutical Engineering II 1 6 Mathematics I 1 7 Anat., Physio. & Patho. III 1 PRACTICALS 8 Pharmaceutical Analysis II Lab. 1 9 Pharmaceutics II Lab. 1 10 Computer Lab. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 2 4 4 4 40 40 40 40 40 40 40 16 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 500 250 Second Year B. Pharm. (SemesterIV) THEORY Duration Hours Min. for Passing Duration (Hours) 1 1 1 1 1 1 1 4 4 4 Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Pharmacology I 1 2 Organic Chemistry IV 1 3 Biochemistry II 1 4 Dispensing Pharmacy 1 5 Mathematics II 1 6 Psychology & Sociology 1 7 Anat., Physio. & Patho. IV 1 PRACTICALS 8 Organic Chemistry II Lab. 1 9 Dispensing Lab. 1 10 Biochemistry I Lab. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 2 4 4 4 40 40 40 40 40 40 40 16 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 500 250 2 | P a g e Third Year B. Pharm. (SemesterV) THEORY Duration Hours Min. for Passing Duration (Hours) 1 1 1 1 1 1 1 4 4 4 4 Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Pharm. Med. Chem. I 1 2 Biochemistry III 1 3 Pharmacognosy I 1 4 Pharmaceutics IV 1 5 Hosp. Pharm. & DSM 1 6 Pharm. Biotechnology 1 7 Pharmacology II 1 PRACTICALS 8 Pharm. Chem. I Lab. 1 9 Pharmaceutics III Lab. 1 10 Biochemistry II Lab. 1 11 Pharm. Biotech. Lab. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 2 4 4 4 4 40 40 40 40 40 40 40 16 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 40 16 550 275 Third Year B. Pharm. (SemesterVI) THEORY Duration Hours Min. for Passing Duration (Hours) 1 1 1 1 1 1 1 4 4 4 Semester Exam. Periodic Test Total Min. Max. marks for Passing Maxi. Marks Max. Marks Subject 1 Pharm. Med. Chem.II 1 2 Pharm. Analysis III 1 3 Pharmacognosy II 1 4 Pharmaceutics V 1 5 Cosmeticology 1 6 Pharmaceutical Management 1 7 Pharmacology III 1 PRACTICALS 8 Pharmacology I Lab. 1 9 Pharmacognosy I Lab. 1 10 Cosmeticology Lab. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 2 4 4 4 40 40 40 40 40 40 40 16 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 500 250 3 | P a g e Pharm. Of Papers Entry 2 2 2 2 2 2 2 4 4 4 40 40 40 40 40 40 40 16 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 500 250 4 | P a g e . marks for Passing Maxi. for Passing Duration (Hours) 1 1 1 1 1 1 4 4 4 4 Semester Exam. Chem. (SemesterVIII) THEORY Duration Hours Min. III 1 3 Pharm. Med. 1 8 Pharm. Med. Marks Subject 1 Clinical Pharm. 1 10 Pharm. II Lab. 1 9 Pharamacognosy III Lab. 1 9 Pharmacognosy II Lab. & Juris. Chem. Max.& Drug 1 Interaction 2 Pharm. Chem. marks for Passing Maxi. Max. Periodic Test Total Min. 1 PRACTICALS 8 Pharmaceutics V Lab. (SemesterVII) THEORY Duration Hours Min. Marks Subject 1 Pharmacology IV 1 2 Pharm. AnalysisV 1 4 PharmacognosyIV 1 5 PharmaceuticsVII 1 6 Novel Drug Delivery Systems 1 7 Forensic Pharm. Pharm.IV 1 3 Pharm. 1 Total Marks for the Semester Minimum marks for passing the semester No. Analysis III Lab. Analysis IV 1 4 Pharmacognosy III 1 5 Pharmaceutics VI 1 6 Biopharm. 1 Total Marks for the Semester Minimum marks for passing the semester No. Of Papers Entry 2 2 2 2 2 2 4 4 4 4 40 40 40 40 40 40 16 16 16 16 16 16 10 10 10 10 10 10 10 10 10 10 50 50 50 50 50 50 50 50 50 50 20 20 20 20 20 20 20 20 20 20 40 16 40 16 40 16 40 16 500 250 Final/Fourth Year B. 1 10 Pharmaceutics IV Lab. for Passing Duration (Hours) 1 1 1 1 1 1 1 4 4 4 Semester Exam. Marks Max.& Pharmacokinetics 1 PRACTICALS 7 Pharmacology II Lab.Final/Fourth Year B. Periodic Test Total Min. Marks Max. Definition of Complex. astringent(Zinc oxide) and Pharmaceutical aid(tale and barium sulphate) 3 hrs/ week Hours 5 2. principle of microscopic reversibility. Anslyn and Dennis A. Inorganic Medicinal and Pharmaceutical Chemistry Varghese Publishing House. donors and acceptors. John H. 6 Reference Books: 1. Curtin principle. Dougherty. 5 4. 1986. Modern Physical Organic Chemistry. Pearson Education 1995 nd Louis P. Kinetic and thermodynamic product control. Inc. General theory of the transaction state. Brief introduction to the inorganic medicinal compounds: antacid(Magnesium trisilicate and aluminium hydroxide ). ChargeTransfer complexes and reactions. rates of acid and base catalyzed reactions. rate determining transition state. An Introduction to Physical Organic Chemistry. 3. 1. Kosower. 2 Edition. Hanunett. Isrie V. John Wiley. and Edward B. 4. Stability of complexes and chelation. Physical Organic Chemistry. the reaction coordinate. 5 | P a g e .D Lee. Physical Organic Chemistry. Coordination Chemistry.. 1968 rd J. A New Concise Inorganic Chemistry. 5. isotope effect on kinetic effect of reaction medium on the rate of the reaction Transition state theory. 6. No. 2006 nd Neil Isaacs.SYLLABUS COPY FOR FIRST YEAR B. General mechanisms of acid and base catalyzed reactions. John Wiley and Sons. 5 5 5 6. Nomenclature. Megraw Hill Education. 1970 Edward M. Charge transfer transition. ground state charge transfer contribution. Theories of bonding in co ordinate complexes. 2. AcidBase Catalysis. Topic Kinetics and Reaction Mechanism. PHARM SEMESTER – I GENERAL CHEMISTRY S. Bronsted catalysis correlation of reaction rates with acidity functions. 3 edition Van Nostrand Reinhold Company Ltd. 2 Rev Edition. 4 3. antimicrobial (hydrogen peroxide and povidoneiodine). 5 6. Inductive effects. 5 Edition. Aliphatic halogen compounds 4 3. bond polarization 3hrs/ week Hours 1. McGraw Hill Companies. Pearson Education Pvt. 3 4. bond length. bond angles. McGraw Hill Companies. Ltd. Topic Structure and Properties of Organic Compounds : Types of bonds in organic compounds. 3. A Guide book to Mechanisms in organic Chemistry. Topic Brief Introduction to human body and organization of human body 3hrs/ week Hours 1 2. 2005 th Peter Sykes. 2006 th Stanley Pine. En. No. 2007 th Francis Carrey. hybridization of orbital’s. inclusion phenomena. Van der Waal’s interaction. Finar. 4. Organic Chemistry. 7 5.. bond energles. Pearson Education. Pearson Education. 7. 6 2 Reference Books: 1. 3.2000 ANATOMY. addition of KMnO4 and Addition reactions across conjugated. Organic Chemistry. sources. with regard to IUPAC nomenclature.ORGANIC CHEMISTRY –I S. SN2 and Sn1 mechanisms. Organic Chemistry. th Robert T. alkynes) Addition reaction of alkenes: Markonikov. Organic Chemistry. 2. Hydroboration. concepts of Hbonding hyperconjugation resonance. E2 and E Discussion of substitution vs. AntiMarkonikov rules. 5. 1. OxymercurationDemercuration. PHYSIOLOGY AND PATHOPHYSIOLOGY I S. Physical properties and general reactions of hydrocarbons (alkanes. 5 Edition. Ozonolysis. formation of the same and bonds formed. Structural and functional characteristics of following tissues · Epithelial · Connective · Nervous · Muscle Detailed structure of cell membrane and transmembrane movement of substances 6 | P a g e 2 2 . No. Boyd. 2007 th H. 4 Edition. 4 2. methods of preparation. Acidity and basicity of molecules Concept of Electrophiles and Nucleophiles Calculations for determining empirical and molecular formulae Mechanism and elementary stereochemistry discussion of SN1. alkenes. 6 Edition. elimination Discussion of the following classes of compounds in brief. 6 Edition. Morrison and Robert N. Newyork. Anne Waugh and Alleon Grant Ross & Wilson’s Anatomy & Physiology in Health & 9 Edition (2001) Churchill Livingstone. London nd 5. G. Mumbai rd 6. Ranade. 2. Pune 30 7 | P a g e . Praful b. Joshi & Shalini Pradhan A Text book of Practical Physiology 3 Edition 1982 P. in detail · Spasticity · Tetany 2 3 8 4 7 1 Reference Books: th 1. Philadelph .G.B. Mackenna & R. Tortora & Sandra Reynolds Grabowaski Principle of Anatomy & Physiology th 10 Edition (2003) John Wiley & Sons Inc. 7. V. Newyork. USA th 3. 8.V. 9. R. Pensylvania. Newyork Edinburgh. Textbook of Medical Physiology 10 Edition (2000) W.4. Arthur C. Components and functions of lymphatic system: · Lymphatic organs and tissues · Organization of Lymph vessels · Formation and flow of lymph Definition and etiology of following diseases in detail · AIDS · Autoimmune disease (Rheumatoid arthritis /Grave’s disease / Myasthenia Gravis / Rheumatic fever) · Hypersensitivity (Allergy) Haematology · Composition of blood · Functions of blood elements · Erythropoiesis · Synthesis of Haemoglobin · Leucopoisis · Coagulation of blood · Blood groups Definition & etiology of following diseases . N. 5. Edinbrigh. 6. Churchill Livingstone. USA th 4. Guyton & John Half. in detail · Anaemias Types of anaemias · Polyeythemia · Leucopenia · Leukocytosis · Thrombocytopenia · Leukemia Structure and Properties of following muscles · Cardiac muscles · Smooth muscles · Skeletal muscles · Neuromuscular transmission and contraction of skeletal muscle · Energy metabolism in the muscle · Types of muscle contractions · Muscle tone Definition and etiology of following diseases. Callander Illustrated Physiology 6 Edition 1997. P. Saunders Company. Godkar Textbook of Medical Laboratory Technology 2 Edition 2006 Bhalani Publishing House. Gerald J. Prakashan. London. B. Thermodynamics 9 · Definition. Isobanic. Isothermal · Types of Properties Intensive and Extensive Property · Equilibrium and NonEquilibrium states · Types of Processes Isothermal Adrabatic. Cyclic Process · Reversible and Irreversible process · First Law of thermodynamics · Enthalpy.PHYSICAL PHARMACY I (3hrs/ week) S. · Bond Energy – Calculation of Heat of reaction from bond energy 8 | P a g e . deviation from Raoults law · Methods to measure vapour pressure lowering and its application (problems) · Distillation of binary mixtures and azeotropic distillation · Concept of steam distillation · Elevation of boiling point and determination of molecular weight (problems) · Depression of freezing point and determination of molecular weight (Problems) · Osmotic pressure: Concept. Application and Limitations · Systems –Homogenous. No. Solutions of Nonelectrolytes: 9 · Units for expressing concentration · Ideal and real solutions · Raoults law. Heat of Solution – Differential and Integral heat of solution. molecular weight determination from osmotic pressure 4. · Viscosity: Definition. significance to pharmacy. Physical Properties of Drug Molecules 6 · Additive. heat Capacity. Topic Hours 1. Heat of Formation. Methods to determine. concept of polarisability and molar · Polarisation · Retractive index and molar refraction and application of moral retraction to determine structures. Gases: 6 · Ideal and Real Gases · Vanderwaals phenomenon · Critical phenomenon. Concepts and applications > Textbook of Pharmacy Subramanyam · Optical rotation and specific rotation and its application 3. Heterogenous · Types of systems Open. cP cVR (Derivation) · Work of expansion against variable pressure Thermochemistry · Heat of reaction. Isochoric. critical constants and their determination · Liquefaction of gases – Linde’s process and Claude’s process · Application of Liquefaction in aerosols introduction to the concept 2. Heat of combustion. constructive and colligative properties with examples · Dipole moment. Closed. Adrabatic. Ktchener. Bahl. Findlay. U. data · Kirehoffs equation. 2006.5. 1994. “Essentials of Physical Chemistry” revised edition. activity coefficient expressing collagative properties. B. Pune 2006. Lippincotts Willians and Wilkin. PHARMACEUTICSI S. T. Ltd. S. Hadkar. Tuli. 8 Edition. “Practical Physical Pharmacy’ revised and edited by J. Topic 9 | P a g e 3hrs/week Hours . 3. “Martin’s Physical Pharmacy and Pharmaceutical Science” 5 Edition. Green and Company Ltd 1967. Bahl. J. G. Sinko. Specific conductance. 2006. Indian Education Distributed by B. B. Hess’s law of constant heat summation · Second law of thermodynamics · Carrot theorem · Efficiency of heat engine · Entropy · Third law of thermodynamics Free Energy and its applications · Pressure and Temperature coefficients of free energy · Maximum net work. Criteria for equilibrium · Chemical potential (only definition) · Gibbs Helmholtz equation · Clausius Clapereyon equation No derivation · Vant Holf equation No derivation Properties of Solutions of Electrolytes · Electrolysis · Faradays laws of electrolysis · Electrolytic conductance. th P. N. 2. 6th Edition Nirali Prakashan. S. · Theory of strong electrolytes · Degree of dissociation · Kohlrauschs law of independent migration of · Application of conductivity measurements conductometric titrations and solubility of a sparingly soluble salt · Equivalent conductance of a weak electrolyte at infinite dilution · Degree of dissociation of a weak electrolyte 9 Reference Books: 1. Hadkar “A Textbook of Physical Pharmacy”. A. Publications Pvt. Vasudevan. K. Chand and company Ltd. 5. Dombivali. 4. Laddha “Practical Physical Pharmacy” Yucca Publishing House. A. Equivalent conductance. New Delhi. Molecular conductance · Transport Number · Measurement of conductance · Variation of equivalent conductance with · Arrhenius theory of electrolytic dissociationcolligative properties. I. No. D. S. B. U. th A. Lonmans. Development of Indian Pharmacopoeia and other Compendia including B. types of flow. . Homeopathy. Publications Pvt. percolation. International pharmacopoeia and B. London. Ltd. Distributed by B. 8. Ltd. J. w/w. V. 2005 th P. Ltd. C. G. Brief overview of status of Pharmaceutical industry in India Introduction to Pharmacopoeias. Sinko. Calcutta.C. I. and 2 2. Indian Edn.P. Published by All India Traveler Book Seller Delhi. 3 33 Reference Books: 1. Historical background to the profession of Pharmacy in India in brief. Publications Pvt. 1992. 3 3. thixotropy and measurement of flow properties Total 3 2 3 1 9.8 Edition Lippincotts Williams and Wilkin. London.U.F. “Martin’s Physical Pharmacy and Pharmaceutical Science” 5 Edition. 3. A method of preparation of extracts includes maceration... 4. 6. Distribution and fate of drug.. Lippincotts Williams and Wilkin. Unit operation of : Filtration and clarification ( Theory and equipment for filtration of solid from liquids ) and mixing Rheology : Definition and concepts.S. st “Remington The Science and Practice of Pharmacy “.P. 2002. Indian Edn. Drug administration: Introduction to bioavailability biopharmaceutics. Lippincotts Williams and Wilkin. I. Formula by weight (w/v. Concepts of drug efficiency and dose response. Introduction to Good Manufacturing Practices and Quality Assurance Introduction to galenicals. 4 5. 7. decoction. Distributed by B. L Shroff “Principles of Pharmacy Part I and II”8 Edn. Ansel “Ansel’s Pharmaceutical Dosage th Forms and Drug Delivery Systems “. Definition of Drug Concept of dosage form and formulation – Scope of Pharmaceutics Routes of administration and physiological considerations Classification of dosage forms and their applications.. Popovich and H. Five star Enterprises. E.1. Bailliere Tindall. Allen Jr. Unnani and Siddha. I. Vol.P.2006 M. infusion and digestion. 5. Indian Education Distributed by B. Indian Edn. Delivery systems: Non – sterile monophasic liquids. Aulton “Pharmaceutics The Science of Dosage Form Design” Churchill Livingstone.. Ph Eur. 6. N. Rowling “Bentleys Textbook of Pharmaceutics” 8 Edn. Introduction to Absorption. v /v); in parts. L. 10 | P a g e 2. Pharmaceutical Calculations: Reduction and enlargement of formula.2005 th M. Introduction to alternate systems of medicine: Ayurveda.. N. A. I and II. 21 Edn. 3 4. 8 10. th E. Publications Pvt. Pumping: · Positive displacement pumps reciprocating pumps. · Heat transfer by convection – Natural convection and forced convection. K. Khat and N. K. 4 . J. Delhi 1993. Lyman and G. 9. (only equation and factors affecting) · Overall heat transfer coefficient · Heat exchangers tubular and plate Mass transfer: · Mass transfer in turbulent and laminar flow · Concept of interfacial mass transfer. flow of fluids in pipes. 13. Heat Transfer: · Modes of heat transfer – conduction. No. R. Mumbai 1986. Harkishan Singh “Pharmacopoeias and Formularies” Vol. compressibility and surface tension of fluids · Hydrostatics influencing fluid flow · Fluid dynamics – Bernoulli’s theorem. Gurbani “The Pharmacist Year Book 1993 st 1 Edn. Varghese Company. H. 2 4. J. 6 3. Indian Edition by K. Philadelphia. Ansel. dimensional analysis.M. 11. 10. Dandiya. C. Heat transfer between fluid and solid boundary. C. 12. CBS Publishers and Distributors. rotary pumps · Centrifugal pumps · Special pumps Measurements: · Measurement of flow – Classification of flow meters. th S. 4 5. venture 11 | P a g e 3hrs/ week Hours 4 2. 8. 1973. Stocklosa. A. 1976. convention and radiation. 1986.”Pharmaceutical Calculations” 8 Edition. I Vallabh Prakashan. · Heat transfer by radiation – Kirchhoff’s law and Stefan Boltzmann law. Delhi. Urdang “American Pharmacy” 5 Edn. P. · Compound resistance in series. th M. Sonnedecker “Kremers and Urdang’s History of Pharmacy” 4 Edn Lippincotts Company. CBS Publishers and Distributors. PHARMACEUTICAL ENGINEERING I Note: Only principles and equipments to be covered No mathematical derivations and numerical problems S. th R. laminar and turbulent flow. Carter “Cooper and Gunn’s Tutorial Pharmacy” 6 Edn.7. James Swarbick “Current concepts in Pharmaceutical Sciences: Dosage form design and bioavailability” Lea and Febiger. Topic Fluid Flow: · Mention fluid properties such as Viscosity. 1. th G. USA. Delhi 1994. · Fourier’s law for slabs and pipes (only equation and factors affecting) · Concepts of thermal conductivity and steady state heat transfer. · Factors influencing rate of corrosion. simple manometer. 12 | P a g e . 2001. W. polypropylene. Pune 2005. Perry and D. Refrigeration and Air Conditioning: · Water vapour air mixture · Hygrometry · Humidification and dehumidification equipments – spray ponds. chlorinated plastics and poly carbonate plastics. Paradkar “Introduction to Pharmaceutical Engineering”7 Edn. Mc Graw Hill Book Company. 10. · Methods of combating corrosion. fluorocarbon plastics. screw conveyor and Pneumatic conveyor. Badger and J. Chemical Hand Book. Centrifugation : · Principle . Ltd. R. U tube manometer and modifications. Bourdon gauge 6. H. phenolic and epoxy plastics. Banchero “Introduction to Chemical Engineering” Mc. Material of Construction: · Classification into metals & nonmetals · Ferrous and its alloys – cast iron. New Delhi. Water Purification: · Pretreatment and purification by deionization. W. objective and requirements of centrifugation · Equipments Hydro extractors. 2. ABS. polystyrene. Conveying of Solids: · Belt conveyor. 7. Nirali Prakashan. 4. T. orifice meter. Sambamurthy “Pharmaceutical Engineering” New Age International Pvt. Total · 1 2 4 1 3 4 35 Reference Books: 1. R.meter. Corrosion: · Mechanism and types of corrosion. pitot tube. th A. 8. natural draft cooling towers and mechanical draft cooling towers. K. 11. Green “Perry’s Chemical Engineer’s Handbook “7th Edn. rotameter and current flow meters Pressure measurement – Classification of manometers. Graw Hill Book Company. polyethylene. mild steel and stainless steel · Copper and its alloys · Nickel and its alloys · Aluminum and its alloys · Glass · Plastics – Classification into thermoplastics and thermosetting plastics Properties and applications of polyvinyl chloride. L. polyster. 1997. Bucket conveyor. reverse osmosis and distillation. · Refrigeration equipment and concept of refrigeration load. concepts of brine systems and absorption systems 9. 3. Blood groups g. Ciliated Epithelium 13 | P a g e 2. Handbook by Kulkarni and Pathak. Mann and B. Laddha “Practical Physical Pharmacy” Yucca Publishing House. B. Published by Dastane Ramchandra and Company PHYSICAL PHARMACY LAB – I 1. Hemoglobin content of blood e. 3. Hadkar. Erythrocyte Sedimentation Rate (ESR)/ Hematocrit (Demonstration) Study of Human Skeleton Microscopic study of permanent slides Tissues: ‐ Columnar. 5. 4hrs/ week 2.ORGANIC CHEMISTRY LABORATORY I 4hrs/ week Organic Sporting: Qualitative analyses of organic compounds – aspects to be covered are solubility characterization and preliminary tests. 4. 2. 6. Determination of heat of solution. 3. Dombivali. 3. Determination of refractive index. th Textbook of practical organic chemistry by Vogel. K.G. Squmaous. Differential Leukocyte (WBC) Count d. U. determination of unknown concentration and specific rotation. 1994. Viscosity: To determine the composition of the unknown binary mixture. Demonstration of Landsberger method. Partition coefficient – Iodine Reference Books: 1.C. functional group characterization. Determination of molecular weight by Rast camphor method. PHYSIOLOGY AND PATHOPHYSIOLOGY – Lab 1. 4 edition. derivative preparation Reference Books: 1. Red Blood Cell (RBC) Count b. Polarimetry: Different Concentrations of sugar. T. S. Using water as a reference standard to determine refractive index of two organic solvent and their mixtures and to determine composition of unknown. ANATOMY. . Vasudevan. Cuboidal. publishers Longman group Ltd. elements detection. Bleeding & Clotting Time f. th Practical Organic Chemistry by F. To determine RI of a solid (KCI) from two concentrations of solid solutions. (4hrs/ week) Hematology a. molar refraction. Saunders. N. Total Leukocyte Count c. 4 edition published by OrientLongman. Uric Acid · Blood Urea Nitrogen(BUN) Blood Glucose Serum Cholesterol/ Triglycerides Serum Alkaline phosphatase (ALT) Serum Acid phosphatase (APT) Serum Lipase Serum Amylase Serum Calcium Serum lactate dehydrogense (LDH) Thyroid Function Tests T3. 5.‐ Cardiac/Skeletal/ Smooth muscle ‐ Ovary. 7. Thyroid. Kidney. T4 Diagnostic tests for infectious diseases like · Malaria · Tuberculosis · Dengue · Leptospirosis 4. 6. 3. Cerebrum. 8. Spinal Cord. Tongue. 12. 2. 14. Liver. Intestine. 9. 14 | P a g e . Pancreas. Artery. Vein 4. Lung.Testis. Measurement of blood pressure Tutorial Discussion on some common investigational procedures used in diagnosis of disease with the help of charts slides Name and Importance of following tests: 1. 13. 11. 5. Electroencephalogram (EEG) in diagnosis of Epilepsy Electrocardiogram (ECG) in diagnosis of cardiac arrhythmia Liver Function Tests · Serum Bilirubin · Serum glutamate oxaloacetate transaminase (SGOT) · Serum glutamate pyruvate transaminase (SGPT) · Urine Bilirubin · Urine Urobilinogen Kidney Function Tests · Serum Creatinine · Serum Urea. 10. Stomach. V. Anne Waugh And Allison Grant Ross & Wilson’s Anatomy & Physiology in Health & th Illness 9 Edition (2001) Churchill Livingstone. USA th Arthur C. 4. Gerald J. Ranade. London. 15 | P a g e . Newyork. Mumbai rd V. 2006 Bhalani Publishing House. 2. Pensylvania. Churchill Livingstone. Hall Textbook of Medical Physiology 10 Edition (2000) W. 5. th B. Joshi & Shalini Pradhan. nd Praful B. A Textbook of practicalphysiology.G.Reference Books: 1. R. Tortora & Sandra Reynolds Grabowaski Principals of Anatomy & th Physiology 10 Edition (2003) John Wiley & Sons Inc. B. Newyork Edinburgh. 6. USA. 3. Prakashan. Mackenna & R. Callander Illustrated Physiology 6 Edition. Newyork. London. G. Godkar Textbook of Medical Laboratory Technology 2 Ed. Edinbruigh. P. Philadelphia.3 Edition 1982 P. Guyton & John E. Pune 030. Saunders Company. N. R. 2. Mackenna & R. Guyton & John E. Reproductive System ‐ Anatomical and Physiological considerations of male and female reproductive system ‐ Menstrual cycle 4. Ranade. N. P. Anne Waugh And Allison Grant Ross & Wilson’s Anatomy & Physiology in Health & th Illness 9 Edition (2001) Churchill Livingstone. G. Pune 30 16 | P a g e 3hrs/ week Hours 4 3 4 2 12 5 . Mumbai rd V. Definition and etiology of following diseases. Prakashan. 5. 3. London . 6. Etiology of hypo and hyper secretion of above endocrine glands and related diseases Reference Books 1. Godkar Textbook of Medical Laboratory Technology 2 Edition 2006 Bhalani Publishing House. in detail ‐ Asthma ‐ Pneumonia ‐ Bronchitis ‐ Emphysema ‐ Respiratory Acidosis and Alkosis 3. Saunders Company. Newyork Gerald J. Joshi & Shalini Pradhan A Textbook of practical physiology. 4. Definition and etiology of following diseases. Hall Textbook of Medical Physiology 10 Edition (2000) W. V. Newyork.SEMESTER – II ANATOMY. London nd Praful B. Edinbrigh. Philadelphia. Callander Illustrated Physiology 6 Edition 1997. Tortora & Sandra Reynolds Grabowaski Principals of Anatomy & th Physiology 10 Edition (2003) John Wiley & Sons Inc. Endocrine System Location hormones and functions of following endocrine glands: ‐ Pituitary ‐ Thyroid & Parathyroid ‐ Adrenal ‐ Pancreas ‐ Tests & Ovaries ‐ Control of hormone secretion 6. Pensylvania. No Topic 1. Newyork Edinburgh. in detail ‐ Infertility ‐ Sexually transmitted diseases (STD) ‐ Dismenorrhea 5. Churchill Livingstone. Anatomy and physiology of Respiratory System ‐ Exchange of gases ‐ External and Internal respiration ‐ Mechanism and regulation of respiration ‐ Lung volumes and lung capacities 2. USA th Arthur C. B. G. PHYSIOLOGY AND PATHOPHYSIOLOGY –II S. USA th B. 3 Edition 1982 P. 4. Mc Graw – Hill Companies. 6 Edition. concept of end point. alkali and alkaline earth metals. 2. sources. nonvolatile 3 matter. strong acids and bases. with mechanisms Alcohols and ethers 4 Carbonyl compounds (aldehydes and ketones) 5 Carboxylic acids.ORGANIC CHEMISTRY – II S. 17 | P a g e . anhydrides. 2006. Mc Graw – Hill Companies. 5 Edition. 10 Huckel rule. Limits tests for insoluble matter. sulphate. redox titrations. 6. Acid base titrations in aqueous medium titrations. 2000. Pearson Education. 3hrs/ week 1. 3. 2007. th Organic Chemistry. Classification of theoretical considerations and applications to 3 volumetric analysis. Pearson Education Pvt. Topic Hours 1. calcium carbonate. 5. argentimetric titrations and nonaqueous titrations with suitable example. weak acids and bases. Preparation and reactivity of polycyclic aromatics – naphthalene’s 6 anthracene and phenanthrene Reference Books 1. molarit. No. arsenic. buffers. molality. Ltd. amides 5 Amines and other nitrogen containing compounds. e. milliequivalence. The theoretical basis and techniques of quantitative analysis.g. complexometric 15 titrations. Organic Chemistry. 5 solvent. primary and secondary standards. structure and resonance in benzene; Nomenclature of aromatics: Electrophilic and nucleophilic sunstitution reactions in aromatic compounds. 4. residue on ignition and ash value. 6 Edition. L. Finar. 5 Edition. iron. methods of preparation. th Morrison and Boyd. A Guidebook to Mechanisms in organic Chemistry. I. solubility product range.P. nitrate. 2006 Stanley Pine. 2. 6.P. Various limit tests prescribed in I. Pearson Education. 4. PHARMACEUTICAL ANALYSIS – I 3 hrs/ week S. boric acid and ferrous sulphate. Solute. solution. Organic Chemistry. 3. Organic Chemistry. chloride. with regard to IUPAC nomenclature. th Peter Sykes. Talc. volatile matter. 6 Aromatic compounds: Concepts of aromaticity and aromatic character. 2007. Introduction to the study of monographs of five official compounds – 4 sodium chloride. definition of normality. Topic Hours Discussion of the following classes of compounds in brief. No. 3 lead. esters. th I. 2. 3. Physical properties and general reactions. theory of indicators (both external and internal indicators). calculation based on stochiometry problems. 5. soluble matter. concentration. 4 Edition. th Francis Carrey. first order and second order reaction. PHYSICAL PHARMACY – II 3 hrs / Week Hours 4 S. isotonic buffer § Solutions. solubility parameters and prediction of solubility in regular solutions § Partition phenomena and partitioning of weak electrolytes and its applications 3. No. application of buffers and concept of tonicity in pharmacy. 3 Reference Books 1. th A. Stanlake. concept of tonicity. 4 edition. Longman Scientific and Technical. Solubility: § Solubility of gases in liquids. 2 8 . Practical Pharmaceutical Chemistry. calculation of pH. (Problems) § Methods to determine order of a reaction § Energy of activation. Chemical Kinetics: § Molecularity. Bekett and J. H. ideal solubility. 3. H. buffers in pharmaceutical and biological systems. TOPICS 1. 5. Estimation studies of important gases – Oxygen. British Pharmacopoeia. 1997. 5 Edition. USP. Interfacial tension § Surface free energy § Pressure difference across curved interfaces § Measurement of surface and interfacial tensionCapillary rise method § Drop weight method § Du Nuoy tensiometer method § Spreading of liquids § Spreading coefficient § Adsorption at liquid interfaces 18 | P a g e 6 8 4. Martindale. order of a reaction and specific rate constant § Zero order. Nitrogen and Carbon dioxide. Arrhenius equation and application § Collision theory and transition state theory § Accelerated stability studies – concepts and applications Problems Catalysis: § Definition. B.7. CBS Publishers and Distributors. effect of pH on § Ionization of weak acids and bases. th G. Bassett. calculation of § Fraction unionized. Ionic equilibria and buffers: § Sorensens pH scale. types and specificity Interfacial phenomena: § Surface tension. 2. Problems 2. Vogels’ Textbook of Quantitative Chemical Analysis. Jeffery and J. henrys law and applications § Miscible liquids and partially miscible liquids § Solubility of solids in liquids. 1989. Indian Pharmacopoeia. Introduction to per formulation studies with respect to monophasics: 9 § Organoleptic properties § Purity § Solubility and techniques of solubilzation § Partition coefficient and dissociation constant. Pune 2006. Green and company Ltd. Vasudevan. th P. S. Publications Pvt. 2. Lippincotts Williams and Wilkin. colloid properties such as optical Kinetic and electrical § Gold number § Protective colloid § Schultz Hardy rule. Longmans. Nirali Prakashan. Chand and company Ltd.6. th A. G. Topic Hours 1. Findlay. B. New Delhi. No. 7. Sinko. S. N. Complexion: 2 19 | P a g e . D. “Essentials of Physical Chemistry ” revised edition. Hadkar. K. 8 Edn. 2006. Bahl. T. Indian Edn. Dombivali.. Salt formation § Polymorphism and crystal habit § Stability and Interaction with excipients. Tuli. § Surface active agents § Hydrophilic – Lipophilic balance § Types of monolayers at liquid interfaces § Soluble monolayers § Gibbs adsorption equation (No derivation) § Insoluble monolayers and film balance § Adsorption at solid interfaces § Adsorption isotherms § Freundlich adsorption isotherm § Wetting angle and Contact angle Problems Electromotive force: § Electrochemical cell § Types of electrodes § Nernst equation and cell emf § pH meter and Measurement of pH § Ion sensitive electrodes § Oxidation reduction indicators § Concentration cells Problems Colloids: § Classification § Preparation. Distributed by B. th U. Hadkar “A Textbook of Physical Pharmacy”. B. Bahl. 2006. 5. 2. U. A. J. 3 5 Reference Books 1. I. 1967.. 6 Edn. “Practical Physical Pharmacy” revised and edited by J. Laddha “Practical Physical Pharmacy” Yucca Publishing House. S. PHARMACEUTICS – II S. B. 4. A. Kitchener. “Martin’s Physical Pharmacy and Pharmaceutical Sciences” 5 edition. 3. 1994. Ltd. G. I. 3. Distributed by B. I and II. Indian Edn. D. Formulation. Rowling “Bentleys Textbook of Pharmaceutics” 8 Edn. J. Urdang “American Pharmacy” 5 Edn. Published by all India Traveler Book seller Delhi. Lippincotts Williams and Wilkin. Distributed by B. Publications Pvt. Lippincotts Williams and Wilkin. Sinko. Indian Edn. 1992. large scale manufacturing. st “Remington The Science and Practice of Pharmacy”.. E. 8. Industrial Pharmacy 2. C. 2002. 2005. Packaging and Quality control of Powders: § Dusting powders § Oral rehydration powders § Dry syrup formulations. J Carter “Cooper and Gunn’s Tutorial Pharmacy” 6 Edn. Lippincotts Williams and Wilkin. Vol. 1986. Philadelphia.. 4. 6. 9.3. Bailliere Tindall London. Ltd. 7. James Swarbick “Current concepts in Pharmaceutical Sciences: Dosage form design and bioavailability” Lea and Febiger. 21 Edn. Hixon Crowell Law 9 7 4 4 REFERENCE BOOKS: 1. L. 5. 2005 th E. 8th Edn. A..” Martin’s Physical Pharmacy and Pharmaceutical Sciences” 5 edition. systems”.I. 5. A Lyman and G. Publications Pvt. th P. Allen Jr.. Publications Pvt. measurement of diffusion. Popovich and H. 20 | P a g e . Powder Technology: § Fundamental and derived properties of powders and their measurement § Size reduction. 2006 M. Ltd. Indian Edn. Delhi. 4. I. 1973. large scale manufacturing. packaging and Quality Control of nonsterile monophasic liquids: § Solutions § Aromatic waters § Syrups § Elixirs § Linctuses § Drops § Glycerites § Paints § Lotions § Liniments § Sprays. Ansel “Ansel’s Pharmaceutical Dosage Forms and Drug Delivery S. Formulation. § Types of complexes and their analysis. Noyes – Whitney equation. N. Diffusion: § Fick’s laws and steady state diffusion. th R. V. Indian Edn Distributed by B. Aulton “Pharmaceutics The Science of Dosage form Design” Churchill Livingston. CBS Publishers and Distributors. Ltd. Dissolution: § Dissolution rate. th S. London. 6. § Size separation. Classification of microorganism as different types 1 5. flagella spore. 7. Microscopy: Simple microscope. Fungi: 2 Morphological characteristics and classification. Dermatophytes. Clostridium self study 2 6. mycosis in brief (Pathogenic fungi like Aspergillus.. Trichomonas. and numerical aperture. Riekketsiae Diseases 1 8. 3.. cultivation and reproduction HIV and oneogenic Viruses. oil immersion microscopy to be covered in practical.. Staphylococcus 2 Sp. factors 2 affecting growth. No. measurement of growth. Salmonella sp. Pathogenic protozoa like Amoeba. Algae: 1 Morphological characteristics. reproduction. Protozoa: 2 Morphological characteristics and classification. habitat nutrition Cultivation of bacteria: 2 Culture media: Cultivation. reproduction. continuous cultivation. Pseudomonas. economic significance of algae 10. Control of microorganisms: 6 Different techniques of sterilization and their application.. Shigella sp.. phase contrast and dark field. Topic Hours 1. scope and application in 1 pharmaceutical sciences 2. Brief history of microbiology: Microbiology. Plasmodium 11. cell characteristic.. Klebsiella sp. cell wall staining Negative staining Motility 4. Staining (All staining with respect to bacteria): 2 Monochromatic staining Gram staining Acid fast staining Capsule. E. Candida albicans) 9. magnification. Classification of bacteria: Morphology. Fluorescent and electron microscopy. storage media. microbiological assay media Cultivation of aerobes and an aerobes Pure culture techniques – isolation Preservation of cultures 2 Reproduction and Growth phases. Viruses: 3 Morphological characteristic. Paramecium. angular aperture. enumeration. Compound microscope. reproduction. enumeration of bacteria 2 Identification of bacteria 2 Overview of bacterial diseases in brief Mycobacterium sp. Introduction to aseptic techniques(no equipments to be covered) Disinfectants and principles of disinfection. enrichment media differential media.MICROBIOLOGY 3 hrs/ Week S. 3 Resolving power.coli. 21 | P a g e . Orient Longman Pvt. H. 2.1N Na2S2O3. th R. I.P. Ferrous sulphate. Inc. E. UK. Hugo and A. 2. USP. heavy metal. J. 7 Edn. 9 Edn. D. Hinsdill. 1997. Determination of ascorbic acid Argentimetric titration NaCl powder and KCl. Pelezar Jr. British Pharmacopocia. Hyderabad. Bassett. 3. Philadelphia 1968. K.. Ltd. 4 edition. 0. sulphate.Reference Books: 1. 4. Paniker “Test Book of Microbiology”. B.P. 4hrs/ week Preparation and standardization of 0. Blackwell Science Ltd.C 22 | P a g e 4hrs/week . R. R. Indian Pharmacopocia. CBS Publishers and Distributors. Copper sulphate.C Ear drops Chloramphenicol ear drops B. 1993. Chan and N.1 N HCI. USA. T. 0. 3. H. J.P 66 Artificial syrup Cough syrup – Codeine phosphate syrup B.P. B. Crabtree and C. th G. Practical Pharmaceutical Chemistry. Frobisher. Goodheart “Fundamentals of th Microbiology”. 5.1 N lodin. 0.C 73 Dill water Gripe water Syrups Syrup I. 2005 PHARMACEUTICAL ANALYSIS LABORATORY – I 1. 2003. Magnesium sulphate.1 N KMnO4. iron. 3. 5 Edition. S.. Stanlake.P 66 Concentrated Anise water B.1 N NaOH. Potassium iodide. Martindale PHARMACEUTICS LAB – I List of experiments Aromatic waters Chloroform water I. limit tests for: chloride. Saunders College Publishing. Vogels’ Textbook of Quantitative: Chemical Analysis. M. 0. Ananthanarayan and Ck. 4. Jeffery and J. Reference Books: 1. arsenic. C. Krieg “Microbiology Concepts and Applications” McGraw Hill. M.C Elixirs Piperzine citrate elixir B.P.P. Assay of Zinc oxide. R. th A. D. Russel “Pharmaceutical Microbiology” 6 Edn. 2. Titrimetric Analysis : Determination of total alkalinity and sodium carbonate of sodium hydroxide determination of percentage of aspirin. Bekett and J. th W.C Linctus Simple linctus B.P 66 Concentrated Dill water I.P. Longman Scientific and Technical 1989. 2.P 55 Glycerin of tannic acid I. nhexane. T. S.P 66 Paracetamol Solubilised Paediatric drops Cresol with soap solution I. Vasudevan. Determination of CMC Phenol water : Critical solution temp and composition Determination of molecular weight of a polymer from solution viscosity Adsorption : Surface area determination HLB of A surfactant Potentiometer : Titration and determination of bufler capacity Reference Books: 1. Determination of surface tension of water. 2. toluene. Laddha “Practical Physical Pharmacy” Yucca Publishing House. 1994.P.P 66 Weak Iodine solution I.Nasal drops Ephedrine sulphate nasa drops B. 4.P Magnesium citrate oral solution N. 4. U.P 66 Solutions Aqueous Iodine solution I. 2. K.P. N.P 55 Glycerin of boric acid I. 5. 3. parachor and critical solution temp determination. Hydrochloric acid/ sulphuric acid Second order reaction (saponification) Determination of order by equal fraction method (first order reaction ) Ostwalds isolation method to determine order NONKINETICS 1. 7. MICROBIOLOGY LABORATORY 1.P. Parnton coefficient Benzoic acid Surface tension: 1. 3. surgical B.C 68 Powders Oral rehydration salt (ORS) Evaluation of liquids for specific gravity and viscosity and powders for bulk density. 4hrs/week Relative strength. Dombivali. B Hadkar. 6.C Glycerites Glycerin of starch I.C Iodine Paint compound B.F XIV Chlorinated soda solution. 3. flow rate and angel of repose PHYSICAL PHARMACY LAB – II KINETICS 1. Study of microscope and common laboratory equipments Gram staining Monochrome staining 23 | P a g e 4hrs/ week . 2. Colony characterization and growth patterns in broth of cocci and bacilli Total count by Breeds smear method Growth by optical density. 13. 14. 6. plates. 5. 8. 12. 10. intestinal amoeba in stools. 9. anoculation techniques. 11. agar slants. Isolation of pure culture by pour plate and streak plate methods. 24 | P a g e . total plate count Study of yeast. Negative staining Cell wall staining Scope staining Capsule staining Motility by hanging drop technique Preparation and sterilization of nutrient broth. 7. Aspergillus and Penicillum with respect to morphology Observation on prepared slides of malarial parasite in blood smear.4. Crohn’s disease ) Cholecystitis & Cholelithiasis Jaundice Hepatitis Pancreatitis Achalasia Reflux esophagitis 3Hrs/ week Hours 9 2. proteins and fats Phases of gastric secretion Definition and Etiology of following diseases in detail Peptic ulceration Zollinger – Ellison’s Syndrome Inflammatory Bowel Disease (Ulcerative colitis. 7 3. Neurotransmitter and neurotransmission Cranial and spinal nerves Sensory and Motor pathways Definition and Etiology of following diseases in detail Epilepsy Parkinsonism Alzheimer’s Disease Cerebral Hypoxia Stroke (Cerebrovascular disease) Anxiety & Depression Mania and Schizophrenia Structure and Function of following sensory organs Eye Ear Tongue Nose Skin Digestive System Parts of digestive system. PHARM SEMESTER III ANATOMY. No. 1. Their structure and functions Digestion and absorption of carbohydrates. 6 4. PHYSIOLOGY AND PATHOPHYSIOLOGY – III S.SYLLABUS COPY FOR SECOND YEAR B. 6 25 | P a g e . 8 5. Topics Nervous System Anatomy and physiology of : Central Nervous System (CNS) Peripheral Nervous System (PNS) Autonomic Nervous System (ANS) Properties of Neurons. Cannizaro. WB Sauders Company. Hoffman. nd 2 Edition Bhalani Mumbai. Kplan. 1997 5. Kumar and Colins. Knoevenagel. 6th Edition. Mackenna & R. 8. Opheim. Perkin. 2006 th 2. 10 Edition. Harris Pathology & Therapeutics for Pharmacists: A nd Basis for Clinical Pharmacy Practice. Pinacol. nbutane and cyclohexanes (mono and disubstituted cyclohexanes to be discussed). th 4 Edition. Dandiya & P. Pune Vidyarthi Gruha Prakashan. No. Nitroaldol Claisen Condensation Michael addition. S and D. N. Schmidt. Newman and Sawhorse projection formulae R. 2 Edition. ORGANIC CHEMISTRY – III S. Williams & Williams. 1. 2001 th 4. Stobbe. Sharma BioChemistry & Clinical Pathology (Theory & Practical). Ross & Wilson Anatomy & Physiology in health & Illness. 2007 th 3. RobinsPathologic Basis of diseases. Stevens. 20 26 | P a g e . 6. NY Churchill Livingstone. 6 Edition. Division of Merek & Co Inc. 1997. Text Book of Therapeutics: Drug and Diseases th Management. Name reactions Aldol condensation. Eric Herfindal. Sommolet. Topic 3 hrs/ week Hours 16 Stereochemistry Optical isomerism; representation of molecules by Fisher. Problems based on the transformations to be solved 2. Pharmpress NY. Godkar. Beckmann. Merck Research Laboratories. White House Station. K. 7 Edition. 12. Conformers of ethane. L notations. 11 Edition.Reference Books: th 1. Tortora & Grabowaski Principles of Anatomy & Physiology. Harcourt Singapore. J. A Wolters Kluvers Company. Godkar Textbook of Medical Laboratory Technology. Lippincott Williams & Wilkins. 11. 10 Edition. Lossen. Toivola Lyon. Churchill Livingstone Elsevier. 2000 9. Geometrical isomerism E and Z nomenclature. Curtius. R. J Wiley & Sons. Dick Gourley. Jack. BayerVilleger. The Merck Manual of Medical Information. Wittig. Dieckmann’s cyclisation. Benzilic acid rearrangement. Reformatsky. 10.C. aspects of stability and optical activity. Guyton & Hall Textbook of Medical Physiology. B. Cotran. P. Home Edition. Clinical Chemistry: Interpretation & Techniques. Praful B. Russel J. Favorskii. London 1995. Darshan P. Greene & Norman D. 2006 7. Anne Waugh. diastereomers and resolution of racemic mixtures. Wolff. Allison Grant. Callander Illustrated Physiology. Ranade & Joshi Manual of Practical Physiology. Czako. Norman. R. factors affecting liquidliquid extraction (Solvent method of extraction stripping and pH effect. 2007. 4 4. Unit 27 | P a g e 2.. polarizer. median. Applications. 6 3. Ltd. Nicol’s prism. definitions – circular birefringence. 4. Soxhlet extractions. Principle (Grazing angle of incidence. precision. 5 Ed. Critical angle of refraction). Eliel. sodium benzoate. Applications. analyser. 2 Ed. 2. O. E. PHARMACEUTICAL ANALYSIS II S. left and right circularly polarized light. 1986. 7. Topic 3hrs/ week Hours 3 Types of errors Concepts of errors: Mean. production of linearly polarized light. 1999. Pine. Thomson Learning. Chapman and Hall. Determinate and indeterminate errors and the ways to minimize them. Tata McGrawHill Publishing Co. Principales of Gravimetric Analysis Theory: Mass as measurement signal and precipitation equilibria. pilocarpine nitrate.. 6 5. 1. accuracy. circular dichroism. Variables in analytical chemistry and scope of pharmaceutical analysis. significant figures. Determination of optical activity (Half shade effect). John McMurry. Dipping type) with construction and working of Abbes refractometer in detail. P. different types of refractometers (Abbes. 5. L. L.. salting out effect. factors affecting measurement of refractive index (pressure. 4 Ed. etc). 5 Ed. McGraw Hill. th Organic Chemistry.Reference Books: 1. nd Principles of Organic Synthesis. Francis Carey. Multiple extractions. 6 . No. sample cell. Tata McGraw Hill Publishing Co. S Kalsi. S. Conformation and Mechanisms.. Solvent extraction Principle. Brooks/ Cole. Strategic Applications of Named reactions in Organic Synthesis. Stereochemistry of Carbon Compounds. relative standard deviation. th Stereochemistry. Ltd. any one nasal drops) Refractometry Snell’s Law. Elsevier Science & Technology Books. 3. Anisotropic crystals.. molecular ellipticity. Kurti and B. Instrumentation: Light source. 5 Ed. March 2005. th Organic Chemistry. temperature). 6. Definitions of specific and molar refraction. Polarimetry Introduction to electromagnetic properties of lightwaves. th Organic Chemistry. monochromatic radiation. 1978. New Age International Publishers 2001. H. wavelength. applications (alkaloids. pulfrich. optical rotatory dispersion. Absolute and relative errors. standard deviation. Unusual sugars like glucose amine.. New York. aldoses and ketoses.operations in gravimetric analysis. Eugene.). India. CBS Publishers & Distributors. 5. 4 edition. hemiacetal/ hemiketal formation. acid catalyzed rearrangement. apparatus. st Takeau Higuchi and Finar Brochmann HanssenPharmaceutical Analysis. Richard S. European Pharmacopoeia. DL notation. application for Ampicillin trihydrate) Kjeldahl’s method (Apparatus. starch. Fischer and Haworth projection formulae (glucose as example).P.. glycosides. analysis of organically bound halogens. methods of digestion of sample applicationanyone from I. 4 edition. 1 edition. BIOCHEMISTRY I S. 1984. Statistical Quality Control. New York th Grant. th Gary ChristianAnalytical Chemistry. cellulose.P. lactose. standardization of KPR as per I. 4 edition. Topic 3 hrs/ week Hours 10 Carbohydrates Definition. CBS Publishers & Distributors. hydrazone formation. Leavenworth. 1986. Reactions of carbohydrates – optical properties.P. mutarotation. U. th Vogel textbook of Practical Organic Chemistry 4 edition. Miscellaneous Oxygen flask combustion method (I. Organic and Inorganic precipitants factors affecting gravimetric analysis.S. amylose).B. 4. Disaccharides and polysaccharides – introduction to structures of simple compounds and their biological role (sucrose. analysis of water by Karl Fischer titrations – preparation of KFR reagent as per I. 28 | P a g e . biological roles. Stability of KFR. I.. P. sulphur and phosphorus. 7. maltose. oxidation. Mc Graw Hill Book Company. CalculationsGravimetric factor Applications: Assay of Nickel by dimethylglyoxime and assay of +2 aluminum by oxine reagent of Ba BaSO4 6. 3 4 3 Reference Books: 1. 1 edition. of Analytical Chemistry. acetate/ ketal formation. Monosaccharides ranging from trioses to hexoses (Fisher projection. st MEITES H. No. assay of di iodohydroxy quinoline) Aquametry Different types of water present in a sample. base catalyzed rearrangement. 1. anomeric carbon. trioses to hexoses. 1997. 1988. 3. Elbs & Longmans. 1972. Tokyo. John Wiley & Sons. London.P.P. B. 2. 1963. names and abbreviations of common sugars). Mc Graw Hill Kogakasha Limit. th Beckett & StenlakePractical Pharmaceutical Chemistry. 6..P. L. reduction. muramic acid etc. Introduction to terpenoids – fat soluble vitamins and cholesterol. introduction to primary. nucleotides. E. tertiary and quaternary protein structure and their features in brief. th Outlines of Biochemistry. sphingolipids. unusual amino acids. Eds.. structures. 10 3. USA. Stryer L. glycolipids. Murray R. structure of DNA. ninhydrin reaction. 6 5. B2. Appleton and Lange. formation of esters.2. 3 Ed. Niacinamide. hydrolysis of fats. th Textbook of Biochemistry with Clinical Correlations. Eds.. PHARMACEUTICS – III S. nitrogenous bases.W. reaction with flurodinitro benzene. Principles of Biochemistry.. th Lehninger. 5 Ed. Freeman & Co. Ed. common fatty acids. shorthand notation. rancidity. Biological role of B12 (without structure). Stumpf P. th Harper’s Biochemistry. Edman reaction. acid value. optical activity. USA. Replika Press Pvt.M. 1988. 5 Ed. Ltd. iodine value. 4 Ed. 6 4. USA. W. side chain reactions. Wiley Liss. Schiff base formation. ester value. 4. folic acid. lipoic acid.H. amino acids – types..K.M. Nacylation. Vitamins Detailed description of the mechanisms involved in the biochemical roles of vitamins A. Mayes P. fats vs oils. rd Biochemistry. B6. No. Reactions of amino acids. names. triacylglycerols. Peptides and proteins. fatty acids – saturated. L.. three letter abbreviations. Bruening G and Doi Roy H.. 2002. 4 Reference Books: 1.. Dansyl chloride reaction. Granner D. Eds. 2000. tRNA and rRNA – their structure and their biological role. and Cox M.. inositol and pantothenic acid. Proteins Definition. India. John Wiley & Sons. 3.. 25 Ed. nucleosides.K. acid base behavior. D.. biotin. Properties of fatty acids – physical properties. unsaturated.. 1987. 2. secondary. 5. Nucleic acids Definition of DNA and RNA. B1.A. Structure and biological roles of some common compound lipids. Topic 29 | P a g e 3 hrs/ week Hours . Lipids Definition. compound lipids – phospholipids. isoelectric pH. Conn. biological roles. 2007. melting and annealing of DNA. peptide bond and its special properties. esterification. brief introduction to semiconservative replication and information flow via mRNA to proteins.. and Rodwell V. hydrogenation of oils. biological roles. K.K. Types of RNA mRNA. E. shorthand notation of DNA polymers. one letter codes. Nelson D. ascorbic acid. Devilin T. Volume 1/ 2/ 3. Theories of emulsification. desirable features. · Ointments. Mumbai. · Q. Lieberman Herbert A. advantage and Disadvantage. Q. 2005. Lachman Leon. Classification and selection. layout. instability of dispersed systems · Suspensions – definition. · Emulsions – Definition. Q. Suppositories · Definition. Lieberman Herbert A. Theoretical (Preformulation) aspects wetting phenomena. Marcel Dekker Inc. “The Theory and Practice of rd Industrial Pharmacy”. 3 Edition 1987. · Selection of bases – Large scale manufacturing and processing with equipments. Preparation of suspension – Precipitation methods and Dispersion method. tests including stress testing. Mechanism of emulsifier’s. 30 | P a g e . advantage & disadvantage. Large Scale manufacture with equipments Q. Sedimentation in suspensions. · Methods used to evaluate percutaneous absorption. · Factors influencing. Gels. Schulze Hardy Rule. advantage & disadvantage. New York. Kanig Joseph L. Davis method.C. 10 3. 2. Rheology aspects. Poultice. tests & stress tests. classification of emulsifiers with examples. Semisolids · Introduction · Introduction to anatomy of Skin. Examples of Preparation. testing. · Manufacturing and Packaging. Example formulations – official preparations. selection of emulsifiers – HLB. 6 Reference Books: 1. · Function of Skin · Percutaneous absorption and Penetration.. Pastes. cloud point determination. Rieger. particle – particle reactions. other additives.C. Droplet stabilization.. stability of emulsion.C. need for emulsion. PIT method. layout Examples – Official preparations. “Pharmaceutical Dosage Forms – Dispersed nd Systems”. Crystal Factors. flocculated and deflocculated systems. · Permeation enhancers. Theoretical aspects – interfacial tension. Varghese Publishing House. Rheology.1. Ointment Bases. 2 Edition.C. desirable features · Anatomy of Rectum in brief & rectal absorption · Suppository bases – Features desired. Packaging. Special Bases. tests · Example – formulations 12 8 2. Biphasic Dispersed Systems: Physicochemical principles thermodynamic. DLVO theory. Formulation Additives. Manufacturing – large scale with equipments. applications Azeotropic and Extractive distillation Theory of azeotropic and extractive distillation. Physical Pharmacy. purification of high boiling liquids. · Equipments employed in solidliquid extractionSoxhlet extractor. The Science and practice of Pharmacy. sieve plate column. 1.. 4. Ltd. Crystallization: · Crystal forms and crystal habits · Theory of crystallizationSupersaturationMier’s 31 | P a g e Hours 2 6 S. 2. st Remington.K. Podbielniak extractor. Rotocel extractor. Bonotto extractor..E. Agitated columns. 6 4. 21 ed. No mathematical derivations and numerical problems Topic Fluidization · Theory of fluidization Extraction: SolidLiquid & LiquidLiquid Extraction · Mechanism and method of extraction process and factors affecting extraction process. Lea & Febiger. 2005. 5.. Packed Columns. Bollman extractor. Steam distillation Theory of steam distillation and applications of steam distillation such as methods of separation of Volatile constituents and preparation of aromatic water. Open tank. Aulton. 5 Theory of . Vortical or Turbo extractor. London. extraction battery and Robert diffusion battery. L. Churchill Livingstone Medical Division of Longman Group. Concept of plate efficiency and HETP (no detailed theories and derivations) Distillation under reduced pressure – Theory of molecular distillation and equipments Falling film and centrifugal molecular distillation still. Publications Pvt. Columns (only construction and working)Plate columnsbubble cap. 4 Ed. Packed columns. 2006. Distillation: · VaporLiquid equilibrium · Distillation methods Equilibrium distillation Simple Distillation Fractional distillation – Theory of batch fractionation. Spray columns. 3..3. PHARMACEUTICAL ENGINEERING II · · Only principles and equipments to be covered. Volume I & II B. Pharmaceutics – The Science of Dosage Form Design. Screw extractor and Hilderbrandt extractor. Philadelphia. Agitated tank. applications such as dehydration of alcohol. No. Ltd. th Martin A. 2002. · Equipments employed for LiquidLiquid extractionMixer settler. Ed. U. M. Scale information. Fluidised bed dryer Pollution from Pharmaceutical Industry: Air pollution and preservation · Wet scrubber. 32 | P a g e . Introduction to Pharmaceutical Engineering. biological treatment. Spray dryer. organic chemicals. supersaturation. Falling film evaporator Forced circulation evaporator. Swenson Walker crystallizer. Pharmaceutical Engineering. 4 Reference Books: 1. dissolved salts. Walter L. dissolved salt removal. vacuum tray dryer. 2007. Nucleation. radiological products. R.· · 5. Bancherro. Marcel Dekker. Encyclopedia of Pharmaceutical Technology. Entertainment separators. Freeze dryer. · Waste treatment processes segregation. 1998. liquid dosage forms.. Mc. neutralization and pretreatment. 3. · Formulation manufacturing sterile product. Crystal growth Crystallizers Classification. INC. Boylon. expansion and bucket traps. 6 Evaporation: · Heat transfer process in boiling liquids in evaporators · EvaporatorsPan evaporators. New York. Rotary drum dryer. New age international (p) limited publishers. Agitated tank crystallizers. Drying: · Mechanism and theory of drying · Dryertray dryer. 4. Introduction to Chemical Engineering. 10 edition. th Dr. acids and alkalis. tunnel dryer. A. Krystal or Oslo crystallizer. K. Nirali Prakashan. Water pollution · Bulk drug manufacture dirty water. short tube vertical evaporator. Horizontal tube evaporator. 1955. Badger & Julius T. solid dosage form. Caking of crystals. 4 7. Graw Hill Inc. preaeration. Tank crystallizers. 8. dust collector. Vacuum crystallizer and its modifications such as circulating magma and DTB crystallizer. Sambhamurthy. James Swarbrick & James C. Industrial hazards and safety: · Fire Hazards and extinguishers · Chemical hazards and extinguishers · Mechanical and electrical hazards · Accidents unsafe action and unsafe condition · Prevention of accidents 6. Wiped film evaporator. 2. Vapor recompression. 1994. fermentation products. vacuum pumps. Evaporator accessories condensers. Paradkar. 5. 6. 7. M. E. Aulton, Ed. Pharmaceutics – The Science of Dosage from Design, Churchill Livingstone Medical Division of Lognman Group, UK, Ltd., 2002. th S. J. Carter, Cooper and Gunn’s Tutorial Pharmacy, 6 edition, CBS Publishers & Distributors, New Delhi, 2005. th Robert H. Perry, Don W. Green, Perry’s Chemical Engineers Handbook, 7 edition, Don W. Green, James O. Maloney, Mac Graw Hill, 1997. MATHEMATICS – I S. No. Topic 1. 3 hrs/ week Hours 5 Differential Calculus: Successive Derivative’s Lebnitz’s rule forth derivative, Lagrange’s and Rolle’s mean value theorems (Statements only), Taylors and Maclaurin’s series (without proof) with application curvature. Partial Differentiation: Functions of two or three variables, change of variables, application to errors, maxima and minima. Integral Calculus: Integration by parts, properties of definite integrals and reduction formulae; Determination of length of the curve area and volume. Differential equations: Formation of differential equations solution of first order and first degree equations, linear differential equation of higher order with constant coefficients, simple application to chemical reactions and biopharmaceutics. Determinants and Matrices: Properties of determinants and applications, solution of simultaneous equations with three variables by Crammers method: Type of matrices, inverse of matrices, rank of a matrices, eigen values and eigen vectors, Caley Hamilton theorem. ` Numerical Methods: Finite difference operator’s (delta and E), interpolation of equal intervalsNewton’s method and Lagrange method: rd th Numerical integrationTrapezoidal rule, Simpson’s 1/3 and 3/8 rules. 2. 3. 3 8 4. 8 5. 7 6. 5 Reference Books: 1. 2. 3. 4. 5. 6. st Mathematics for pharmacy students (Volume I): Gujar, K. N. Bhavale Ashok 1 Edition, Career publication. st Differential Calculus: Nareyan, S. 1 Edition, S. chand Publication. rd Applied Mathematics – I, Baphana R. M., 3 Edition, Techmax Publication. th Textbook of Applied Mathematics Volume I & II, Wartikar P. N. 7 Edition Pune Vidyarthi Griha Prakashan. st Integral Calculus, Shanti Narayan, 1 Editions, S. Chand Publication. th A Textbook of matrices, Shantinarayan, 10 Edition, S. Chand Publication. PHARMACEUTICAL ANALYSIS LABORATORY – II 1. 3 hrs/ week Preparation and standardization of 0.05 M EDTA and 0.1 N perchloric acid. 33 | P a g e 2. 3. 4. Redox titrations assay of sodium nitrite (KMnO4 method). Assay of sodium nitrite, assay of methyl paraben/ propyl paraben, determination of sulphur in sulphur ointment, assay of Lugol’s solution, assay of hydrogen peroxide, assay of isoniazid. Complexometric titrations Assay of aluminium hydroxide gel, determination of percentage of calcium and magnesium in a mixture, assay of calcium gluconate powder and injection, assay of zinc. Sulphate powder. +3 +2 +2 Gravimetric analysis Al as Aloxinate, Ba as BaSO4, Ni as Nidimethyl glyoxime. Demonstration experiments: 1. Nonaqueous titrations assay of pyridoxine hydrochloride, assay of Norfloxacin/ Metronodazole, assay of chlorpromazine hydrochloride. 3 hrs/ week PHARMACEUTICS LABORATORY – II 1. 2. 3. 4. 5. 6. SUSPENSIONS: (a.) Paediatric Kaolin Mixture B.P. 1980, (b.) Paediatric Chalk Mixture B.P. 1988, (c.) Calamine Lotion I.P.’ 66, (d.) Kaolin Poultice I.P.’ 66, (e.) Microscopic evaluation, rheology and sedimentation rate studies for any one of the above suspension. EMULSION: (a.) Liquid Paraffin Emulsion I.P.’ 66, (b.) White Liniment B.P.C., (c.) Turpentine Liniment I.P.’ 1966, (d.) Benzyl Benzoate Application I.P.’ 66, (e.) Microscopy of any of the above emulsion OINTMENTS: (a.) Simple Ointment I.P.’ 66, (b.) Sulphur Ointment I.P.’ 66 (Microscopic evaluation), (c.) Emulsifying Ointment I.P.’ 66, (d.) Benzoic Acid Ointment, Compound B.P.C’ 68, (e.) Iodine Ointment, Nonstaining B.P.C.’ 68, (f.) Iodine Ointment, Nonstaining with Methyl Salicylate B.P.C. 1968. CREAMS: (a.) Cetrimide Cream B.P. 1993. GELS: (a.) Diclofenac Sodium Gel PASTES: (a.) Titanium Dioxide Paste. COMPUTER LABORATOY S. No. 1. Topic 4 hrs/ week Hours 2 Computer Devices a. Input and Output devices b. Secondary storage units c. Memory ROM and RAM Virtual memory d. ALU, the Control Unit, and CPU e. Classification of Computers – Microcomputers, personal computers, laptop computers, minicomputers, mainframes and supercomputers. Operating Systems (OS) a. Purpose of the OS b. Management functions of OS c. Services provided by OS d. Types of OS e. User interfaces – command line and GUI 34 | P a g e 2. 2 f. Features of the MSDOS, Windows and UNIX OSes g. k. Features of the MSDOS, Windows and UNIX OSes 3. Types of Computer Language a. Need for interpreter b. Computer Program c. Interpreter d. Compiler e. Classification of Computer Languages – Conventional advantages and limitations f. Very brief introduction to C++ Language. Introduction to Computer Networks a. What is a Computer Network b. Networking Basis c. Common types of Networks – LAN, WAN and their variations d. Network topologies – bus, ring, star, mesh e. Network Protocols f. Network components – Computers, communications medium, modem, repeater, hubs, switches, bridges, gateways, routers, and network interface cards. Algorithms and Flowcharts a. Algorithm b. Characteristics of algorithm c. Writing algorithms d. Flowcharts and symbols, drawing a flowchart Divide and conquer strategy Introduction to Data structure a. Types of data structures b. Arrays c. Structure or records d. Stack e. Queue f. Linked Lists g. Tree Introduction to DBMS and SQL a. Features of DBMS b. Introduction to Relational Database Management Systems (DBMS) c. Introduction to Ingres DBMS General applications of Computers in Pharmaceutical Sciences. CONCEPTS OF NETWORKING Introduction to Networking, Types of Networking (LAN, MAN, WAN, VWAN), Topologies, Requirements for using Networking, Networking Terminologies (Client, Server, Node, Terminals etc.) Introduction to Operating System, Features of Operating systems, types of operating systems, Difference between 35 | P a g e 3 4. 4 5. 2 6. 2 7. 2 8. 9. 2 4 hrs 10. WINDOWS 11. Session 1 1 Dos and Windows Starting and Shutdown of PC, Screen Components, Notepad (File Menu) Notepad Complete with all menus 12. Session 2 13. Session 3 14. Session 4 WordPad File and Edit Menu WordPad complete with all menus Paint – all tools, Paint – all menus – paint complete Character Map, Control Panel (Date & Time, Keyboard, Mouse, Display) Creation of files and folders, moving files, copying files, Recycle bin, Run, My Documents, My Computer, Finding Files and Folders, doubts clearing. 1 1 1 15. MSOFFICE 16. (A); WORD PROCESSING 17. Session 1 Introduction to package, language, MSoffice and introduction to word; File and Edit Menu; View menu options. Insert menu options; Format font (full), paragraph and change case Format bullets and numbering, columns, bullets and numbering, borders and shading, tabs. Table menu full, Tools – spelling and grammar, thesaurus, mail merge with single field, multiple field and queries options. Macro, autocorrect, letter wizard Envelop and labels, window menu options Drawing toolbar options, Drawing toolbar draw option. 1 18. Session 2 1 19. Session 3 1 20. Session 4 21. Session 5 (B); EXCEL Session 1 1 1 1 Introduction to screen, components (database, spreadsheet and chart), use of excel, auto fill, fill handle features, calculator with ‘=’ sign, sum and average function Edit menu, View menu, Inset menu Format menu, spelling and grammar, protection, autocorrect, goal seek, macro, options (view and custom lists); Data – sort, forms, subtotals, filters, pivot table. Window menu complete, numeric and date and time functions; Numeric functions: ABS, FACT, COUNT, COUNTBLANK, POWER, MOD, PRODUCT, MIN, MAX, QUOTIENT; Date and time functions: NOW, TODAY, TIME Text functions: LOWER, UPPER, PROPER, MID, REPLACE, LEN, TRIM, CONCATENATE, LEFT, RIGHT; Logical function: AND, OR, NOT, EXACT. Introduction to PowerPoint, creating presentation with auto content wizard 36 | P a g e Session 2 Session 3 1 1 Session 4 1 Session 5 1 (C); POWERPOINT 1 Creating presentation with design template, custom animation, slide transition, sounds and songs insertion Creating different types of blank presentations Points to be noted while creating PowerPoint presentations 1. No spelling Mistakes 2. Proper Clipart in each slide 3. Proper Slide Transition Effects 4. Proper Text Animation Effects Proper Timings INETERNET SYLLABUS Session 1 Theory of Internet, basic requirements to run internet, web site, domain name, sub domain, chatting, email, surfing, Surfing and creating email ID Inbox, compose, sending and receiving greeting cards, text files, images downloading, search engines (google, yahoo, Lycos, khoj etc.) Chatting, yahoo messenger and other things. 1 Session 2 1 Reference Books: 1. 2. 3. 4. Basic Electronics and Computer Applications, Rajiv Khanna, New Age International Publishers, 2007. Introduction to Biostatistics 7 Computer Science, Y.I. Shah, A. R. Paradekar, M. G. rd Dhayagude, Nirali Prakashan, 3 Ed., 2004. Fundamentals of Computers, V. Rajaraman, Prentice Hall of India Pvt. Ltd., 1986. Schaum’s Outline Series. Theory & Problems of “Introduction to Computer Science”, by Francis Scheid, McGraw Hill Book Co., 1983. 37 | P a g e 2006. N. organs & tissues. 2001. Mechanism of drug action: a) Brief introduction of physiological receptors structural and functional families cytoplasmic second messengers b) drugreceptor interaction doseresponse relationship drug antagonism Drugs used in the disorders of gastrointestinal tract · Emetics. Churchill Livingstone. Elsevier. antiemetics & prokinetic drugs · Purgatives & antidiarrheals. 6. 2005. Hardman. S. Lee th E. Handbook of Experimental Pharmacology – 3 Edition Vallabh Prakashan New Delhi. R. 2007. K. & Rege N. D. Churchill Livingstone 2003. Alfred Goodman Gillman 11 Edition. 8 3. The McGraw – Hill Companies Inc. Limbird .SEMSETER IV PHARMACOLOGY – I S. 8 4. 7 Reference Books: 1. 2. 2006. Pharmacology & Therapeutics 20 Edition Popular Prakashan. antispasmodics · Drugs used in the treatment of hyperacidity & peptic ulceration · Inflammatory bowel diseases Drugs used in haematological disorders Antiplatelet agents Anticoagulants Thrombolytic agents Antianaemic drugs 3 hrs/ week Hours 13 2. No. S. 1. · Drug Toxicity in human Toxic effects of drugs on different systems. th Satoskar. rd Kulkarni. D. metabolism and excretion. th Rang & Dale Pharmacology – 5 Edition. th Lewis Pharmacology – By Crossland – 5 Edition.. 38 | P a g e . N Y. 5. Bhandarkar S. 3. & Bennet Clinical Pharmacology – 9 Edition. rd Lippincott’s Illustrated Reviews: Pharmacology – Lippincott – Raven 3 Edition Howland & Nycets Publishers N Y. 7. distribution. 4. R. · Factors modifying the actions of drugs. Goodman & Gilman’s Pharmacological Basis of Therapeutics Joel G. th Laurence. Topic General principles of pharmacology · Introduction to Pharmacology · Routes of drug administration with special reference to their advantages and disadvantages · Drug absorption. standard 39 | P a g e . th Heterocyclic Chemistry. Thomson Learning. 2004. 8 5 12 Reference Books: 1. A. L. Concept of oxidation – reduction reactions. Katzung – Basic and Clinical Pharmacology 9 Edition Appleton and Lange publication. 5 Ed. G. pyrazole. th Organic Chemistry. 2005. quinoline and isoquinoline. termination of free radicals. pyrazine and indole. 4. th Organic Chemistry. Relationship of standard free energy to reaction equilibrium constant. 9. John McMurry. Finar. Polymer Chemistry: Introduction to Polymers. 2005. standard electrode potential. ORGANIC CHEMISTRY – IV S. introduction to first and second law of thermodynamics. photochemical methods. 2. 5 Ed. N. Kolbe electrolysis. 2007. Pearson Education. No.. electrolysis). Organometallic chemistry: Introduction organomagnesium. Sandmeyer reaction. transformed standard electrode potential. methods of forming peptide bond including solid phase peptide synthesis. R. imidaxele. 2 Ed. Vols. – Fundamentals of Experimental Pharmacology.. 6. Hilton & Company. organolithium and some mixed organoboranes. 2005. S. propagation of free radicals. Norman. Topic 3 hrs/ week Hours 6 Biochemical Energetics: Concept of free energy. th B. No. oxazole. 3. 5 Ed. 5. amino acid protecting agents. 1999. polymer characteristics. pyridine. Chapman and Hall. nd Principles of Organic Synthesis. oxidationreduction. J. th Organic Chemistry. Joule and K. 1. concepts of enthalpy and entropy. rd Gosh M. isoreazole. 5. generation of free radicals (thermal decomposition. properties. McGraw Hill th Organic Chemistry. I. Chemistry of the peptide bond. 5 Ed. Hunsdiecker reaction. 1. furans. 6 3. 4. Tata McGraw Hill Publishing Co. Ltd. Francis Carey. H. Calcutta. O. Peptide Chemistry. 3 Edition. 4 Ed. Standard free energy changes of some important biological reactions. thiophene.. methods to determine properties. BIOCHEMISTRY II S. Pine. Topic Introduction to free radical chemistry. stability and structure. standard free energy vs transformed free energy vs free energy for a reaction.. 3 hrs/ week Hours 6 2.. Blackwell Publishing. thickzole.8. pyrimidine. Heterocyclic aromatics synthesis and reactions of five and six numbered rings with one and two heteroatoms like pyrrole. 1 and 2. 1978. Discussion of Birch reduction. Mills. Brooks/Cole.. No. muscle. Principles of Biochemistry. India. anabolism and catabolism. Conn E. Salvage pathways for nucleic acids. Ltd. acetate mevalonate pathway. enzymes. rd Biochemistry. M. 1988. Discussion of proton motive force and generation of ATP by use proton gradients. formation of ketone bodies.. 25 Ed. 2007. 4. th Harper’s Biochemistry. with respect to the location.. TCA + cycle. absorption of light by chlorophyll and energy conservation. 4 6. rerelease and interconversion. Lipid metabolism: Discussion of the oxidation and biosynthesis of saturated and unsaturated fats with respect to location.electrode potentials of some biological important redox couples. glycogen synthesis and breakdown.. A.. gluconeogenesis. biosynthesis of cholesterol. Concept of high energy phosphate bond and ATP as a carrier of energy. 4 Reference Books: 1. Fate of absorbed nutrients and relationship with regard to immediate use. and Cox M. Stryer L. storage. th Textbook of Biochemistry with Clinical Correlations. 3 Ed. glyoxalate shunt. L. 3. intermediate. pentose phosphate pathway. 3 3. Devlin T. Bruening G and Doi Roy H. Granner D. brain and rbcs. Wiley Liss. energy yield and regulation. K. intermediates. cofactors. enzymes. 5 Ed. enzymes. energy yields or requirements. th Outlines of Biochemistry. Stumpf p. 1987. USA. NADH/ NAD shuttles. th Lehninger. 3 7. Introduction to the terms metabolism. Carbohydrate metabolism: Discussion of glycolysis. intermediates. Example of drugs interfering with these pathways. 2. 2. Nelson D. tissue.. amino acids and fatty acids into circulation. and Rodwell V.. 3 4. and regulation. Examples of drugs that are related to lipid metabolism modulation. K.. W. kidney. comparison of this with photosynthesis and photophosphorylation. Mayes P. K. adipose. USA. Freeman & Co. Examples of some toxins that interfere with ETC. DISPENSING CHEMISTRY S. Murray R. John Wiley & Sons. 2000. 13 5. H. Eds. Topic 40 | P a g e 3 hrs/ week Hours . Role of different organs in these process especially liver. 2002. W. M. Appleton and Lange. Nucleic acid metabolism: Discussion of biosynthesis of purines and pyridines with respect to location. Ed. Digestion of food and absorption of monosaccharides. 5 Ed. 4 Ed. and regulation. Replika Press Pvt.. USA. Concept of oxidation states of carbon in different compounds. Examples of drugs related to carbohydrate metabolism modulation. Electron transport chain: Components of the ETC oxidative phosphorylation vs substrate level phosphorylation. Eds. 5.. reversal of glycolysis. suspensions. Pharmaceutical Practice Edited by A. Husa’s Pharmaceutical Dispensing. 3. 1957. C.J. Sixth edition. 2004. Churchill Livingstone. posology. 3. Dispensing of properties 1 4 8 4. Gustafson and Stoklosa.E. 7. Churchill Livingstone ELBS edition. suppositories. 1991. Compounding and Dispensing aspects of solutions (for oral use. for body cavities).E. No. Cooper and Gunns Dispensing for Pharmaceutical students Twelfth edition Edited by S. emulsions and creams. gels. Third Edition. Definition of Compounding and Dispensing Prescription and its parts: Different types of prescriptions. capsule. Richards.1. 5. 1998. isotonic solutions. lozenges. 4. Richards.F. pastes. HLB value calculation. Ansel and M. pessaries. Lea and Febiger. 4 5. Pharmaceutical Practice Edited by D. Carter Indian edition CBS Publishers. Stoklosa. storage and stability of products. recording of prescription Calculations: various calculations involved in compounding and dispensing such as weights and measures % calculations.M. Basic principles in compounding and dispensing: Types of dosage forms. Second edition Churchill Livingstone. median and mode Measure of dispersion: Range. containers and closures for products. powders. Pharmaceutical Calculations – by Bradley. Delhi 1987.J. Aulton. tablets. Winfield and R. 1966. external use. imperial system of weights and measures. 2. 1. etc. Collett and M. dilutions and concentrations. pills. 2. J. M. formulation of dispensed products. Pharmaceutical Calculations – by H. Winfield and R. granules. ointments. 6. tablet. Pharmaceutical Practice Edited by A. Edited by Eric Martin. triturate. 2 2 2 2 2 3 2 1 Reference Books: 1. prescription pricing.M. Third Edition. Incompatibilities Prepackaging. quartile deviation mean deviation 41 | P a g e 3 hrs/ week Hours 08 18 . 2. MATHEMATICS – II (FUNDAMENTALS OF STATISTICS) S. Labeling of dispensed products Preparation of stock solutions; Latin terms and abbreviations. 2006.J. Topic Measures of central tendency: Arithmetic’s mean. Lippincott Williams and Wilkins. pastilles. Mack Publishing Company. Mendham. R. 10 Reference Books: 1.and standard deviation. moments generating. 1. C. Pearson Education Pvt. Denney. skewness. John Wiley & Sons. Probability expectations and variance. 1 Edition. Personality tests) 3. th Fundamentals of statistics: Gupta. 2. th Vogel’s Textbook of Quantitative Chemical Analysis. Cormich D. Gujor K. Coefficients of variation. Vrooms. R. and kurtesis. C. Topic Nature. Work Motivation: Theories (Maslow’s Herbergs. moments. Mathematics for pharmacy students (VolI). testing of attributes. career publication. 5. 6 Edition Himalaya publication. Y= aX . st Biostatistics in pharmaceutical Industry. Y =ac } 3. Bhavale Ashok Edition. Equity Theory). Organizational Behavior – Nature Scope Goals. C. binomial. Personnel Selection Occupational Informationuses Personnel Specifications Job analysis Selection techniques: Application BlanksBiodata Interviews Psychological tests (Intelligence tests. st Measurement. 6 Edition. Testing equality of two means and proportions. Matcel Decker Inc. J. PSYCHOLOGY AND SOCIOLOGY 3 hrs/ week Note: All relevant topics can be dealt with special reference to the Pharmaceutical Industry Psychology S. FTest and analysis of variance. 2 h X bX { Y=a+bX:Y = a+bX+cX . Buncher. N. 3. Ways to 42 | P a g e 4 2 Hours 2 . S. Industrial Psychology. 2. Fitting of curve by the method of least square. Definition of PsychologyIntroduction subfields of Psychology. Y= ab . 4. statistics of computation C. Ltd. 1 Edition. Students ‘t’ test for single sample and paired observation. Sampling distribution for mean and Proportion: Test of hypothesis for specified values of means and proportion for large samples.. Chisquare distribution. Poisson and Normal distributions. No. Aptitude tests. 6. Nirali Prakashan ANATOMY. Allopathic medicine in India. Industrial Democracy: Workers participation in management. Team and Team building Accidentcauses Accident preventionsafety measures 7. 1. industry and society: Impact. Class composition of medical students. Medicine and EnvironmentRene Du Bos (1969) Organizational BehaviorHuman Behavior at work –By New Strom and Keith Davis Organizational Behavior –By Suja Nair. Overcoming resistance.motivate people in organizations Financial and nonfinancial Incentive. 3. 9. Career Publication Industrial Psychology and Sociology –By B. Himalaya Publishing Company Industrial Psychology and Sociology –By Milind Wagh. 4. 5. Organizational changeResistance. Role. 6. PHYSIOLOGY AND PATHPHYSIOLOGY – IV S. leadership skills. B. 8. medicine and environment. LeadershipTrail – theory of leader. Electrocardiogram (ECG) 43 | P a g e 3 hrs/ week Hours 12 . Pathak. Topic Cardiovascular System Functional anatomy of heart conducting system of heart cardiac cycle. 7. No. 3. Job satisfaction. leadership styles Fielder’s contingency model. Continuous and episodic change 4 2 2 2 2 SOCIOLOGY S. Topic Concept of: The relevance of sociology to industry. Sociology by Anthony Giddnes Industrial Relation by P. V. 2. 1. Problems (with special reference to Pharmaceutical Industry) Sociology of Medicine in India: an approach. 4. Social adjustment of workers Communication its levels and types. Science. Its relevance to Pharmacy – Pharmaceutical Marketing. technology. 4. The best of both the worldbringing traditional medicine uptodate. Mammudity Sociology by Harrambus Sociology Change by Kappu Swami Man. 3 Reference Books: 1. No. Who chooses modern medicine and why? Man. Hours 3 3 3 6 5. 2. 5. Ranade & Joshi Manual of Practical Physiology. Y. th 3. 2000.. Saunders Company. 44 | P a g e . 11 Edition. Wiley & Sons. chemoreceptors vasomotor center Humoral and Neuronal Control of Blood Pressure and circulation. Godkar. Harris Pathology & Therapeutics for Pharmacists: A nd Basis for Clinical Pharmacy Practice. Inc. White House Station. J. B. The Merck Manual of medical Information. Cotran. N Y. th 4. Churchill Livingstone Elsevier. Lippincott Williams & Wilkins. Tortora & Grabowaski Principles of Anatomy & Physiology. W. 10 Edition. 7 Edition. Kumar and Collins. A. N. 1997. 6 4. th 10. 6 Edition. Mackenna & R. 7. Jack. electrolyte balance & acidbase balance Formation of body fluids and fluid compartments. 6. B. 9. 2007. Functional anatomy of blood vessels Blood pressure and factors regulating blood pressure Baroreceptors. th 2. Robins – Pathologic Basis of diseases. 4 4 Reference Books: th Ross & Wilson Anatomy & Physiology in Health & Illness. Harcourt Singapore. Opheim. 2 Edition Pharmapress. Hemorrhoids Urinary system: Anatomy and Physiology of Urinary System Formation of urine Water balance. 5. Enterohepatic circulation 2. Division of Merck & Co. th 4 Edition. Callander Illustrated Physiology. 6 Edition. Kaplan. 1997. Bhalani Mumbai 2006. Eric Herfindal. Russel J. 5. nd 2 Edition. Definition and Etiology of following diseases in detail Renal failure Glomerulonephritis Renal calculi/ Kidney stones Urinary Tract Infections (UTI) 10 3. Alison Grant. Definition and Etiology of following diseases in detail Hypertension Congestive Cardiac Failure Cardiac Arrhythmia Angina Pectoris Ischemic Heart Disease Arteriosclerosis/ Atherosclerosis Varicose veins. Wolters Kluvers Company. Williams & Williams London 1995. 2006. 2001. J. Pune Vidyarthi Gruha Prakashan. Merck Research Laboratories. N. Praful B. Home Edition. Toivola. Churchill Livingstone. Lyon Clinical Chemistry: Interpretation & Techniques. Guyton & Hall Textbook of medical Physiology. Darshan P. 6 Edition. Dick Gourley. R. Anne Waugh. 8. 1. Greene & Norman D. 11. Godkar Textbook of Medicinal Laboratory Technology. Textbook of Therapeutics: Drug and Diseases th Management. steam distillation. Eutectic mixture 2. Lozenge/ Bismuth Carbonate Lozenges 24. Purification techniques solvent selection for recrystallisation. Sodium Bicarbonate Ear Drops BP 4. Lozenges 15. simple distillation. Mg Trisilicate Oral Powder BP 1988/ Dusting Powder 17. Granules 10. Incompatibility 17. Compound Rhubarb Pills BPC 1960/ Potassium Permanganate Pills 22. Menthol & Eucalyptus Inhalation 7. Pastilles 14. Powders 9. Emulsion 4. Capsules 12. Compound Bismuth Subgallate Suppositories BP 1980 25. fractional distillation. Seidlitz Powder 16. Calciferol Emulsion 9. Zinc & Coal Tar Paste/ Titanium Dioxide paste 12. Suspensions 3. complete characterization if individual components including physical constants followed by preparation of suitable derivative. Medicated Pastilles 23. Prepackaging 45 | P a g e . Gels 7. Lubricating Jelly 13. Effervescent Granuales 18. Ointment 5. Pills 13.ORGANIC CHEMISTRY LABORATORY II 4 hrs/ week Techniques in Organic Chemistry: Quantitative separation of binary organic mixture by physical and chemical methods mixture of different types including compounds with more than one functional group to be given. Solutions 4 hrs/ week 1. Arachis Oil Emulsion 8. Pediatric Ferrous Sulphate Solution BP 1988 5. Chlordiazepoxide Capsules 21. Zinc Chloride & Zinc sulphate mouth wash BPC 2. Calamine Lotion IP 6. Suppositories 16. Cream 8. Sulphur ointment BPC/ Calamine & Coal Tar Ointment/ Whitfield’s Ointment 11. Oily Calamine Lotion BP 1980/ Benzoyl Benzoate Application BP 1988/ White liniment 10. Tablet triturates 11. Boric Acid/ Riboflavin 20. Isapghul Granuales 19. KMnO4 solution 3. Paste 6. recrystallization techniques. DISPENSING PHARMACY LABORATORY 1. Medicated Cream 14. Hyoscine HBr Powder 15. Brompton Cough. precipitation reactions of proteins Determination of acid value. estimation of sucrose: Simple colour reactions of proteins and amino acids. iodine value and sap value of lipids Enzymes: Ptyline activity of saliva 46 | P a g e .BIOCHEMISTRY LABORATORY – I Quantitative test for carbohydrates confirmatory tests by osazone formation 4 hrs/ week Quantitative estimation of glucose by Willstates and Lane and Eynon method. 5 5. rifampin. 2. chemical nomenclature. No. generic names. Combination therapy. structure including stereochemistry. PenicillinV. like halofantrine and lumefantrine: DHFR inhibitors like pyrimethamine* and cycloguanil and sulfonamides like sulfodoxine. Antitubercular agents – PAS*. pyrazinamide. Chemotherapeutic agents – a. sulfadiazine*. azithromycin – only highlights of structure to be discussed); aminopglycosides (gentamicins and neomycins – only highlights of structure to be discussed); Chloramphenicol. ethonamide. chlortetracycline. of the class of drugs. doxycycline and miocycline and its prodrug – rolitetracycline); macrolides (erythromycin. Antileprotic drugs – dapsone* and clofazimine Antimalarials – Natural products like cinchona alkaloids (with stereochemistry and drug action) and artemisinin and its derivatives like artether and artemether and artesunate. viomycin and cycloserine – the first three only highlights of structure to be discussed). Antibacterial agents a. ethambutol*. nafcillin. Quinoline methanols eg mefloquine: misc. isonamide. b. intermediate and long acting sulfonamides. cephalosporins (cephalexin. fluconazole and itraconazole. ampicillin*. classification. b. physiochemical properties. cephalothin. oxacillin. 10 . cefotaxime. Topic Physiochemical properties and drug action Metabolism Discussion of the following classes of drugs including.SYLLABUS COPY FOR THIRD YEAR B. amoxicilline*. Synthetic antimalarials such as 8aminoquiacridines eg. for burn 47 | P a g e 3 hrs/ week Hours 4 6 3. molecular mechanism of action. SAR. amphotericin B and nystatin (later two only general aspects of structure related to activity) and the antifungal azoles like clotrinazole. Antifungal agents – Natural products like griseofulvin. cefuroxime. 4 6. Antibiotics – penicillins (natural and semisynthetic penicillins like Penicillin G. chemistry. sulfonamides for ophthalmic infections. introduction to rational development if any. 6 4. Combination therapy. rocithromycin. antitubercular antibiotics (streptomycin. and sulfalene. PHARM SEMSETER V PHARMACEUTICAL MEDICINAL CHEMISTRY – I S. cefaxitin. oxytetracycline. metabolism. 1. Primaquine. methacillin and ampicillin prodrugs like bacampicillin and pivampicillin). ketoconazole. cefepine and cefpirome) tetracycline. Sulfonamides – Short. Michaclis – Menten equation and meanings of Km and Vmax and identification of inhibition patterns via LWB and Eadic 48 | P a g e 5 2. Williams. John H Block and John M Beale. concept of posttranslational modifications (examples of glycosylated proteins. Vols. Solid phase peptide synthesis. No. Examples of protein synthesis inhibitors used as drugs. conjugated proteins. Baltimore. Vol. EDrug Synthesis Eds. Roth. Williams & Wilkins. Eds. difference between prokaryote and eukaryotes. gatifloxacin d. The Art of drug Synthesis. Sanger dideoxy method and automation of DNA sequencing) Protein Biosynthesis: Details of DNA transcription and RNA Protein. A. J. T. th Medicinal Chemistry. Foye’s Principles of Medicinal Chemistry. 2007. insulin). 5. L. 2004. 2.therapy and for intestinal infections. 1. Topic 3 hrs/ week Hours 8 DNA replicator: Details of DNA replication. 3. 8 . 4. sparfloxacin. A. DNA sequence (MaximGilbert method. Wiley Interscience. th 11 Ed. Fluroquinolones like norfloxacin. pH on enzyme reactions. 1988/ The Organic Chemistry of Drug Synthesis. 6. BIOCHEMISTRY III S. Ellis Horwood Ltd. 4 Edition. ulcerative colitis and for reduction of bowel flora. 1 to 7. 2002. Oxazolidinediones 2 1 * indicates synthesis to be discussed Reference Books: 1. Douglas S Johnson and Jie Jack Li. Eds. Solid phase DNA synthesis. concepts of introns and exons and intron splicing. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry. Ashutosh Kar... telomeres and telomerases DNA polymorphisms and single nucleotide polymorphism. Pharmaceutical Chemistry. difference between prokaryotes and eukaryotes. Enzyme kinetics: Classification of enzymes. ciprofloxacin*. transition state theory. Examples with DNA or interfering with DNA replication. General mechanisms of enzyme catalysis acid base catalysis. proximity effects. H. c. Effects of enzyme concentration. Edman reaction based protein sequencing and its automation.. Wiley. substrate concentration. New Age International Publishers. Kleeman and T. Lippincott Williams & Wilkins. temperature. etc. 2007. Eds. oxidationreductions. Beissewenger. 7 3. Lemke and D. Daniel Lednicer. drying. fixed oils. modification of enzymes for regulation. Mayes P. fruit. 5 Ed. 4. maceration. storage. Eds. flower. Pharmacognosy of crude drugs Cultivation. K. ayurveda. Stryer L. PHARMACOGNOSY I S. 4. Primary and secondary metabolites and their biosynthetic pathways. Replika Press Pvt.. 2. Introduction to newer techniques of extraction. 1.. Methods of extraction (percolation. No. th Textbook of Biochemistry with Clinical Correlations. India. mineral and marine with one example of each class). kinetic factors. 2002. Study of terpenoids. K.. Wiley Liss. M. 2007. Examples of drugs that enzyme inhibitors. H. collection.. 4 . Introduction to medicinal botany with respect to barks. cascade systems. K.. Ltd. th Lehninger. Chinese etc.. 5 Ed. USA. preparation. Commerce and trade of drugs of natural origin. cosmetic etc. siddha. 3 Ed. Methods of classification and their significance in the study of drugs of natural origin (alphabetical.. chemical. Principles of Biochemistry. and nutraceuticals. wood. 2. th Outlines of Biochemistry. 4 Ed. 3. namely.. leaves etc.. Bruening G and Doi Roy H. M. USA. 2000. and quality control of drugs of natural origin. seed.Hofstee plots. root..) of different classes of phytochemicals from crude drugs. Appleton and Lange. shikimic acid pathway. W. L and Cox M. John Wiley & Sons. soxchlet etc. animal. Nelson D. Ed. and pharmacological) and sources of drugs of nature origin (Plant. rd Biochemistry. A. th Harper’s Biochemistry. unani. Devlin T. Plant cell structure with respect to cell organelles and cell contents 49 | P a g e 3. Topic Origin. chemataxonomical. Eds. acetate hypothesis and polyketides with one example of each class. USA.. 4 7. Stumpf P. 1988. 5. Metabolic regulation: Brief description of the following: Enzyme compartmentalization. 6 5. Murray R. and Rodwell V. Granner D. 6 6. 8 Reference Books: 1. taxonomical. 1987.. 6 8. 3 4. biological. 25 Ed. Conn E.. repression and induction of enzymes and their regulation via modulation of transcription and translation. W. Freeman & Co. scope and history of Pharmacognosy 3 hrs/ week Hours 2 2 Literature and information about official and related text available about herbals and drugs of natural origin concept of authentication of crude drugs Role of Pharmacognosy in allopathy and traditional systems of medicine. P. & Robbers J. 15. Purohit A. Bristol. 1. C. 3.: Practical Pharmacognosy; New Vrinda Publishing House. 12. 13.A. B. 11. 10. Topic 3 hrs/ week Hours 2 3 7 Tablets · Definition Advantages and Limitations Preformulation aspects · Tablet formulation and design additives excipients with examples · Large scale manufacturing with equipmentsfor drying. 9. Introduction to plant tissue culture and its technique and applications plant growth regulators and hormones. Layout of tablet section. Bladt & Zgainski; plant Drug Analysis; Springer Verlag. Saunders.: Pharmacognosy; Nirali Publications.S. & Evans W. 14. A. Physics of tablet compression (brief). N. & Turner T. Dry Granulation (Slugging And Roller Compaction) · Compression – (Single station tablet press and Rotary press). Iozenges. London. Kokate C. : Pharmacognosy of Powdered Drugs; Manipal Power Press.: The Practical Evaluation of Phytopharmaceuticals: Wright. sublingual.; Text Book of Pharmacognosy; CBS Publishers. Khandelwal K. 4. Jalgaon. N. Capsules 50 | P a g e 5 4 6 2.R. Vasudevan T. Trease D. & Gokhale S. B.: Phytochemical Methods: A guide to modern techniques Analysis: Chapman & Hall.K. · Tablet types: Effervescent. Vasudevan T. Tyler V. E. 7. Pune. Brain K. Buccal. 3 Reference Books: 1. Direct compression. 8. G. Iyenger M. Medicinal Plants: Intercept Limited. Kokate C. D. 5. R. Scientica.: Practical Pharmacognosy; Vallabh Prakashan.: Practical Pharmacognosy Techniques and Experiments; Nirali Prakashan. USA. idoblasts etc. 9. 2.: Anatomy of Crude Drugs: Manipal Power Press Manipal. B. 6. Bruncton J.: Pharmacognosy. chewable. . S. Harbone J.such as starch grains. E. in tabletting.: Pharmacognosy; Lea Feibger. Pune. Manipal. Jalgaon. E. Processing problems. & Laddha K. Wagner. Vrinda Publication House. K. Delhi.: Text Book of Pharmacognosy: W. Granulation. Iyenger M. R. Wallis T. Dispersible. Orodispesible Q. The Indian Pharmacopeia: The Controller of Publication; Delhi. PHARMACEUTICS IV S. mixing. Phytochemistry. & Nayak S.. of Tablets. Laddha K. Brady L. No.: A Textbook of Pharmacognosy. soluble. C. calcium oxalate crystals. tests. 4. 1. storage. Dispersions. two phase & three phase systems.. Soft Gelatin Capsules Raw material Gelatin desirable properties. 2. 2005. Lachman Leon. Pharmacy and therapeutics committee: Objective. 1987. Mumbai. preparation. Purchasing procedure. Soft Capsule properties. 1995.. selection. Glass. HOSPITAL PHARMACY AND DRUG STORE MANAGEMENT S. A. New York. Mention of gelatin substitute – vegetarian capsules. Containers – Tin Plate. tests. organization. Lieberman Herbert A. storage and inventory control Dispensing of controlled substances: Hospital control procedures Prepackaging. th E. · Components – Prepellantstypes. C. Lieberman Herbert A. Volume 1/2/3. “The Theory and Practice of rd Industrial Pharmacy”. “Pharmaceutics The Science of Dosage Form Design”. Ed.. 3 Edition 1987.· · Hard capsules – Raw materials. Foams Powders. 3 Edition. Large scale manufacturing Rotary Die Process Packaging Q. Churchill Livingstone Publishers. Varghese Publishing House. Ballierwe Tindall. Aluminum. manufacturing and bulk compounding of large volume 51 | P a g e . Lachman Leon. Acrosols · Definition. Hard capsules Development & Technology. 6. Hospitals. 5.. 5 3. Ridgways K. Hard capsule fill formulation aspects. Large scale manufacturing filling of hard capsule shells. 5. Product concentrate Different formulation systems solution. manufacturing of hard capsule shells. 2002. 8 Edn.. contents a few examples. Valve. Q. filling equipments with examples (stress or principle of equipments). Marcel Dekker Inc. Pharmaceutical Press London. Plastics. disadvantage. Kanig Joseph L. Bentley’s Textbook of Pharmaceutics. & Actuator Standard valve (detail) & specialized valves (in brief). composition and function Hospital formulary: Advantage. classification. Topic 3 hrs/ week Hours 1 1 2 2 2 1 2 Hospital pharmacy – history and development. 2. sealing. 3. 3. Administration and functions. Packaging – strip & Blister packaging equipments. Layout of capsule section. Schwartz/ Joseph B. 2 Edition. advantages & disadvantages. No. Duties and responsibilities of hospital pharmacist. “Pharmaceutical Dosage rd Forms Tablets”. size.. nature of shell & contents. desirable features.. 7. Reference Books: 1. 4.C. gelatin manufacturing (brief). nd Aulton Michael E. Rawlins. syringes. Functions and Services. 52 | P a g e . 1941. 1 1 14. “A Textbook of pharmacy management” Tomiski (Kugan page). clinical thermometers. Partnership. Systematic Want Book. Sole proprietorship. Health accessories: Wheel chairs. P. 15.parenterals. Battase. plan. therapeutic and diagnostic radiopharmaceuticals. and facilities required protection of operators. Lea & Febiger. Sterilization and disposal of surgical materials. 13.. 1 2 2 17. 10. ABC. powders and other materials. 21. Use of computers in hospitals Introduction to Pharmacy Practice · Pharmacy Trade or Profession · Reorientation from Product to Patient Focus Code of Ethics for a Pharmacist Community Pharmacy :Scope in India and Abroad Channel’s of distribution · Wholesalers & Retailers and Their role. th Hospital pharmacy: William E. 4. vaporizers. Central sterile service: Advantages. needles. canes. catheters. syringes. 19. 2 12. restricted to retail only viz. half life. Classification. 23. Open to Buy Budgeting. Mcgraw Hill. Lea and Febiger. 8. 1999. “Drug Store and Business Management” A. surgical instruments. “Drug store and management” Nolen and maynard. Use of computers for inventory control) Sales Promotion Risk Management & Insurance Policies for Shopkeeper Frauds in Retail Practice: How to prevent them 2 9. location. Medical gases: Therapeutic use of gases; colour coding of cylinders. Unique Publication. needles. 2. Company and Cooperative Society. Clinical applications of radiopharmaceuticals: Introduction to particulate radiation. 1 1 11. care of cylinders and accessories. Battase Unique Publication. 2 18. 5 Edition. Philadelphia. first aid suppliers. 1 1 1 Reference Books: 1. Entrepreneurship: Trails of Entrepreneur and Development as an Entrepreneur Location analysis Layout Design (Exterior and Interior) Purchasing and inventory Control (Methods. Want Book. crutches. 20. bedpans. 5. 3. 16. “Principles and methods of pharmacy management” Smith. 1 1 1 2 22. VED and EOQ Analysis. 24. Forms of business Organization (in brief) Hindu Undivided family. Sterilization of rubber gloves. total parenteral nutrition and intravenous additives. Hassan. · Specific Defence Mechanism – Characteristics. Autoimmunity. Historical Perspectives. physiological phenomenainflammatory response. th A textbook of Hospital: S. PHARMACEUTICAL BIOTECHNOLOGY S. cellular. Production of penicillin. Career Publication. cosmid. 2000. Maharashtra. Standards for raw materials of natural origin (pharmacopoeial with some examples) Microbiological assays Basic principles. 6 . Gene expression 53 | P a g e 5. complement fixation. Humoral immunityantibody structure and types. · Factors affecting pathogenicity and infection. RIA. 2001. factors affecting fermentation and down stream process. B. First Edition. 20 Edition. resistance. fever. ELISA · Immunological productsVaccines & Sera Definitions and Classification. Published Lippincott Williams & Wilkins. susceptibility etc. design of fermenter. Ligase. Tipnis and Dr. 8. 4 Edition. Shah Prakakshan. No. 4 6. Introduction to single cell protein. Topic 3 hrs/ week Hours 1 1 2 12 Introduction to Biotechnology. Q. some examples. Antigen. Hospital Pharmacy: Dr. Fermentation Technology Example of products of fermentation (microbial. S. Definitions.. mediators; soluble (humoral) mediators. Recent trends in vaccines. 1. 2007. Typical Examples of each type. 2. Pathways of immune response. Tests. H. YAC). Cellmediated immunity. 7. H. Outline of general method of preparation of bacterial & viral vaccines. organization of immune systemorgans & cells involved. Vectors (Plasmid. amylase. · Introduction to diagnostic markers. agglutinin. Quadry. Alkaline phosphatase. Introduction to termsinfection. C. immunoflueroscence. Scope. J. dextram. · Innate defence mechanism – first line of body defence. aspects. · Serologyprecipitin tests. th Gennaro Alfonso R. Relevance to Pharma Industry Microbiological Limit testsNeed. Clonal selection theory · Hypersensitivity & Allergy · Immunodeficiency states Primary & acquired. Amrita Bajaj. Merchant and Dr. pathogen. infestation. SI nuclease. phagocytosis. “Remington: The Science and Practice of Pharmacy”. S. 3. Introduction to rDNA technology Details of restrictions endonuclease. biological oxygen demand. P. Immunology · Hostmicrobe interactions. Ahmadabad. types of fermenters. animal and plant). 4.6. introduction to biosensor with immobilized enzyme e. 9.. Kumar. animal cell culture with diagnostic applications Reference Books: 1. animal expression system.g.(Bacterial expression system. International Edn. P. 8. glucose oxidase. MicrobiologyConcepts and Applications. Yeast expression system. A textbook of microbiology by Ananthnarayan. Hugo and A. Churchill Livingstone. No. Introduction to Chemotherapy Basic principles of chemotherapy Mechanism of action of chemotherapy agents Mechanism of resistance to chemotherapeutic agents Antibacterial drugs Sulfonamides and Trimethoprim Quinolones & Fluoroquinolones Penicillins. 7. 5. Lehninger principle of Biochemistry by David. Chan & Krieg.. cephalosporins & cefamycins & other β lactum antibiotics Tetracyclines Chloramphenicol Aminoglycosides Erythromycin 54 | P a g e 8 . Site directed mutagenesis. Biotechnology by B. cDNA library. 2 3 10. C. Techniques used in molecular biology Introduction to polymerase chain reaction. B. 3. Introduction to gene therapy. 2. Plant expression system) Application of rDNA technology for production of Pharmaceutical products e. Inc. Pelezar. 8 Edn. D. electrophoresis. Nelson.g. Dubey. Introduction to Hybridoma technology – Production and application of monoclonal antibody. Topic 3 hrs/ week Hours 6 2. interferon 7. McGraw Hill. 1. 4. D. D. Definition of enzyme and cell immobilization. Weir Stewart: Immunology. covalent binding. 1 A textbook of biotechnology by R. Biotechnology by H. 1993. PHARMACOLOGY II S. Kori. blotting techniques. Russell. 6. transgenic animal and transgenic plants. matrices with example).. 9. Pharmaceutical Microbiology by W. example of immobilization. S. 4 8. DNA sequencing. Vyas and dixit Pharmaceutical Biotechnology by S. Pharmaceutical Biotechnology by S. 1997. penecillinase. th 10. entrapment. human growth hormone. Insulin. genomic library. methods for enzyme immobilization (adsorption. Singh. The McGraw – Hill Companies Inc. 2007. D. Chemotherapy of following diseases Amoebiasis Malaria Helminthiasis e. Fungal infection g. 4. Calcutta. Goodman & Gilman’s Pharmacological Basis of Therapeutics Joel G. th Satoskar. Katzung – Basic and Clinical Pharmacology. 8. th B. S. Lee th E. 10 Reference Books: 1. 2005. & Rege N. Hilton & Company. N. 2005. rd Lippincott’s Illustrated Reviews: Pharmacology – Lippincott – Raven 3 Edition Howland & Nycets Publishers N Y. Acetylation (synthesis of aspirin & acetanilide or benzanilide) 2. 2003. Bhandarkar S. G. – Fundamentals of Experimental Pharmacology. 9 Edition Appleton and Lange publication. Elsevier. N. 2006. 9. Tuberculosis & leprosy f. Churchill Livingstone. 2006. R.. 7. Limbird. th Rang & Dale Pharmacology. Nitration (synthesis of pnitroacetanilide or mdinitrobromobenzene) 4. S. 2.Macrolides 3.. Popular Prakashan. K. Handbook of Experimental Pharmacology – 3 Edition Vallabh Prakashan New Delhi. & Bennet Clinical Pharmacology 9 Edition. N. Cancer Drugs used in endocrine disorders Antidiabetic agents Antithyroid agents Oxytocies Oral contraceptives Bone Metabolism & Drugs used in Osteoporosis (Bone Structure & Composition. Oxidation (synthesis of benzoic by oxidation of toluene or benzyl alcohol with alkaline potassium permanganate) 5. 5 Edition. Viral disease h. Churchill Livingstone th Laurence. Bromination (synthesis of pbromoacetanilide or pnitrobromobenzene) 3. Alfred Goodman GillMan 11 Edition. 6. D. rd Gosh M. Pharmacology & Therapeutics – 20 Edition. Bromination (synthesis of sodium toluenepsulfonate or pNylenesulfonate acid) 55 | P a g e . R. Bone Remodeling. rd Kulkarni. th Lewis Pharmacology – By Crossland – 5 Edition. Hardman. 3. 3 Edition. 2001. disorders of Bone and Drugs used in Treatments) 12 4. 2004. Y. 5. PHARMACEUTICAL CHEMISTRY LABORATORY – I 4 hrs/ week Introduction/ transformation of functional groups in molecules 1. lipase Chromatographic separation of amino acids. Granulation. 8. ammonium sulphate precipitation. conventional Bulk density. acetone precipitation. compression and evaluation of Paracetamol tablets IP 96 7. Granulation for Soluble aspirin tablets IP and evaluation 3.P. – Hard Gelatin Capsule Shells.6. Esterification (synthesis of nbutylacetate from nbutanol and acetic acid) Demonstration of reaction monitoring by TLC. Starch. Assay of alkaline phosphatase. Granulation and Compression of Ascorbic acid tablets IP 96 6. oxidase. Tragacanth. 7. PHARMACUTICS LABORATOY III 4 hrs/ week 1. flow properties. blood cholesterol Estimation of protein by Biuret method and Folin Ciocalteau method Estimation of RNA Estimation of Vitamin E and Vitamin C Extraction of enzymes. Dissolution test for paracetamol tablets IP. 5. compression and evaluation of Chewable antacid tablets. Granulation compression and evaluation Riboflavin in tablet IP 96 4. Determination of Km of any one enzyme. compressibility and discussion of observations B) Evaluation of excipients – disintegrating agents Swelling index determination and discussion of observations. BIOCHEMISTRY LABORATORY II 4 hrs/ week Colorimetric estimation of blood sugar. Study of factors affecting rate of an enzymatic reactions: Effect of activators. Partial purification by alcohol. αamylase. PHARMACEUTICAL BIOTECHNOLOGY LABORATORY Air Microbiology by solid and liquid impingement methods Coliform Count of water by MPN technique Test for Sterility as per IP 4 hrs/ week Microbial Limit test on Excipients as per I. polyphenol. protease. directly compressible diluents. or rate of enzymatic reaction. inhibitors. Granulation. Vogel Johnson and Medium for S typhi 56 | P a g e . Reduction (Ketones. Lactose Studies on selective media: McConkey Agar. Evaluation of Capsule shells. Cetrimide Agar. filling of ampicillin trihydrate capsules and their evaluation. synthesis of benzhydrol by reduction of benzophenone with zinc and sodium hydroxide) or synthesis of mnitroaniline by partial reduction of m dinitrobenzene with sodium polysulfide.A) Evaluation of excipientsbulking agent. C) Evaluation of excipients of tabletLubricants glidents 2. Urease. introduction to zone of inhibition and calculation Immobilization of enzymes and cells by calcium alginate. Protease. Nitratase. gelatin and agar Isolation of DNA Selection and isolation of bacteria by replica plating Determination of thermal of bacteria b replica plating Effect of UltraViolet exposure on growth of E coli Demonstration of electrophoresis either by PAGE or Agarosegel electrophoresis 57 | P a g e . Amylase and IMVIC) Antimicrobial assay of antibiotic.Antibiotic Sensitivity test by disc method Widals test tube agglutination method Biochemical Tests (Catalase. Oxidase. Amino ethers – pramoxine d. 4 3. 4 . Diureties a. prednisolone. Antihistamines H1. metformin b. Amino esters – procaine. Thiazolidinediones such as troglitazone. glypizide. proton pump inhibitors like omeprazole and lansoprazole. 5 4. ciglitazone. eugenol Hypoglycemics (Insulin not to be discussed) st 1. Emphasis to be on the second generation H1 antagonists such as fexofenidine.SEMSETER VI PHARMACEUTICAL MEDICINAL CHEMISTRY – II S. Topic Steroids – Configuration 5 α and 5 β cholestane. stanozolol and androizoxazole: non steroidal estrogens like diethylstilbestrol and cholotrianisene. cholorpropamide. addition. Biguanides e. astemazole. benzocaine b. H2 receptor antagonist like cimetidine*. mepivacaine. methazolamide. bupivacaine c. rosiglitazone and pioglitazone 3. Site 1 Carbonic anhydrate inhibitors acetazolamide*. ethinyl estradiol and mestranol: progestines like medroxy progesterone acetate. hydrocortisone. Site 2 High ceiling or loop diuretics is sulfamoyl anthranilic acids like furosemide*. dexamethasone. tetracaine. tolazamide and nd rd acetohexamide: 2 Generation like glyburide.g. ranitidine. famotidine. betamethasone and triameinolone. Site 4 Potassium sparing diuretics such as spironoloactone triamterene and amiloride Local Anesthetics a. Site 3 Thiazide and Thiazide like diuretics d. Reactions in ring A & B of steroids – conformation and chemical reactivity. Medicinal chemistry of steroids: Sex hormones (androgens like testosterone and its esters: estrogens like estradiol. 3 Generation like glimepride and repaglimide. No. antiestrogens like tamoxifen and clomiphene. relative rates of esterification and oxidation of epimeric alcohols and reduction of ketones. Amino amides – lidocaine*. 58 | P a g e 3 hrs/ week Hours 9 2. loratidine cetrizine and acrivastine. conventional formula and conformational representation. azosemide and bumetanide in phenoxyacetic acids ethacrynic acid* c. Alcohols – Benzyl alcohol. voglibose and miglitol. megesterol acetate. rearrangement reactions. b. anabolic steroids like danazol. 3 5. H2 receptors. norethindrone and norgestrel). nizatidine. 2. Sulfonylurea’s 1 Generation like tolbutamide *. epoxide opening. 1. β – Glycosidase inhibitors like acarbose. corticoids and steroidal antoflammatory like cortisone. elimination. 4. and other natural products like vincristine. methotrexate*. H. Daniel Lednicer. indoxuridine*. lomustine. amantadine*. th 11 Ed. Eds. 2002. Beissewenger. b. 7 Reference Books: 1. araC. Foye’s Principals of Medicinal Chemistry. bathochromic and hypsochromic shifts. Auxochromes. acyclovir. A. electronic spectra.. Baltimore. ritonavir (only highlights of structure). Eds. J. spectrophotometers. PHARMACEUTICAL ANALYSIS III S. 6. photometers. Ashutosh Kar. A. 2007. John H Block and John M Beale. Lippincott Williams & Wilkins. The art of Drug Synthesis. transmittance. Beer Lamberts law (Definition. doxorubicin. Combination therapy Antineoplastics a. Pharmaceutical Chemistry. Vol. 1. busulfan. alkylating agents like mechlorethamine. th Medicinal Chemistry. Eds. wavelength. cyclophosphamide*. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry. Topic 3 hrs/ week Hours 2 Basic concepts in spectroscopy Introduction: Electromagnetic radiation and interaction with matter. 15 . L. 2. Kleeman and T. mitomycin C. Williams. Antiviral agents including HIV – araA. 1988. Applications of Beer’s law to single component analysis 59 | P a g e 2. Combination therapy * indicates synthesis to be discussed 4 7. The Organic Chemistry of Drug Synthesis. Roth. Ellis Horwood Ltd. Antimetabolites like azaserine. hyperchromism and hypochromism. Lemke and D. limitations). 3. Wiley Interscience. UVVis absorption spectroscopy electronic transitions and UV spectra. 5. New Age International Publishers. 1: Drug Synthesis. Antibiotics like dactinomycin. Vols 1 to 7. T. HIV agents –both nonnucleosides like nevirapine & delaviridine and nucleosides like AZT and protease inhibitors like indinavir.. 5fluorouracil. chromophores.6. derivation of mathematical expression. Miscellaneous compounds like cisplatin and some newer derivatives e. Eds. paclitaxel (only highlights of structure to be discussed) d. saqvunavir.. 2007. No. Williams & Wilkins. chlorambucil*. wavenumber. 4 Edition. 2004. carmustine. 6MP and 6TG c. ganciclovir and ribavirin. Douglas S Johnson and Jie Jack Li. John Wiley. frequency. bleomycin. vinblastine. dacarbazine and procarbazine. absorbance. single standardisation. Saunders College Publishing. Infrared spectroscopy I. simultaneous equation method. th Vogel textbook of Practical Organic Chemistry 4 edition. London. 2. 5.L. 3 edition. effect of solvents. potential energy diagrams (harmonic oscillator and anharmonic oscillator). 4 edition. Instrumentation: light source.and multicomponent analysis (calibration graph. 1992. th SkoogPrincipals of Instrumental Analysis. Vibrational frequency. double standardisation. detectors. 6 5. Quantitative fluorescence intensity. factors influencing vibrational frequencies.R. USA. New York. Mc Graw Hill Book Company. L. 4 edition. 4. 6 edition. 3. identity by fingerprinting). 3. 6. regions. Qualitative applications (identification of functional groups. primary and secondary filters. Instrumentationlight sources. detectors. double beam I. single beam and double beam spectrophotometers. frequency selector. MunsonPharmaceutical Analysis: Modern methods. vibrational and rotational transitions. detectors. Marcel Dekker Inc. Instrumentation and Applications of: · Coulometry · Polarography & Pulse polarography · Amperometry · Electrogravimetry 3 4. Electrochemical methods Theory. Flbs & Longmans. 1981. monochromators.. cells. applications. combination bands and overtone bands). New Delhi. th Beckett & StenlakePractical Pharmaceutical Chemistry. absorption. sample preparation. India. DeanInstrumental Method of Analysis. types of molecular vibrations. standard absorptivity value. 1969. Filters. spectrophotometer (schematic diagram). 1984. with block and ray diagrams. derivative spectroscopy). Fluorescence spectroscopy origin of fluorescence and phosphorescence spectra. Introduction.R.H.R. 1986. USA 60 | P a g e . requirements for I. th Willard H. Merrit & John A. singlet and triple states. dipole changes. 10 Reference Books: 1. James W. difference spectroscopy. 1988. Instrumentation Light sources. factors affecting fluorescence intensity. CBS Publishers & Distributors. CBS Publishers & Distributors. vibrational modes (normal mode. rd Ewing Galen WInstrumental Method of Chemical Analysis. monochromators. honey. spermaceti wax. sunflower. safflower. guar). 6. polyacetylenes (stearolic acid. ash value. ashoka. croton. 2 . tamarind. Pyrethrum. cod halibut and sharkliver oil. coca butter. woolfat. Study of chemistry. pectins. chemical and biological methods of evaluation. Kino. constituents and uses of carbohydrate containing herbs i. fruits (citrus. gums (tragacanth. All cellulose derivatives. almond. alkenes.PHARMACONOSY II Drugs mentioned in bold are for detailed study S. Introduction to Pesticides of natural origin – Introduction study of following with respect to their occurrence. 1. physical. 5 3 4. 61 | P a g e 2. Detailed pharmacognostic study and application of galls. garcinia. Lycopodium spore method. sterculia. sources preparation and uses. Detailed morphology and microscopy of organized drugs and evaluation parameters for unorganized drugs mentioned in bold. hyaluronic acid. falcarinone. ethylene. for crude drugs with respect to pharmacopeias. catechu (pale and black). Quantitative microscopy.isapghol. hydnocarpus. (Cassis latin fistula. Nanthan. rice bran. lecithin. extraction & composition of lipids and uses: Arachis. acacia. mustard. fig. behra Study of Lipids (Waxes. jajoba. Introduction to W. arjuna. linseed. sources and uses of Tannins. fixed oils) their chemistry and classification. Introduction to organic acids. neem. coconut. extraction. Hydrocarbons Introduction to composition. cottonseed. 4 5. alginic acid. beeswax. wheatgerm. neem. Red squill. Topic 3 hrs/ week Hours 7 Evaluation and Significance of quality control of drugs of natural origin (DONO) Study of organoleptic. thiophenes from tagetes). starches. inulin. diagrams of microscopic objects to the scale with camera lucida. No. linseed) malt and malt extract. castor. sesame. carnuba wax.O. properties. olive. 2 2 7. microscopic.e. dehydro matricaria esters. Detailed study of carbohydrates with respect to chemistry. amla). chitin.H. guidelines and monographs of drugs of natural origin. Study of sources. 3. Study of following with respect to sources. microbial bioburden etc. camera lucida. Study of kokum butter. bael. harda. nicotin. tamarkind kernel powder (TKP). classification. isoalkanes and anti isoalkanes. properties & sources of alkanes. Physicochemical parameters such as moisture content. chemistry and applications. dextram. heavy metals content and pesticides residue. 2 8. 5 9. Mucilages (agar. acid insoluble ash. fats. Leaf constants. : Anatomy of Crude Drugs: Manipal Power Press. Pune. Wagner. Study of sources.A. 3. PHARMACEUTICS V S.: Textbook of Pharmacognosy; W. lyenger M. 12.: Practical Pharmacognosy: Vallabh Prakashan.: Pharmacognosy; Lea Feibger. 2 2 Trease D. Laddha K.N. Scientica. Intercept Limited. 9. Topic 3 hrs/ week Hours 12 Tablet coating · Need for tablet coating · Sugar coating – Raw materials. The Indian Pharmacopoeia: The Controller of Publication; Delhi. protein hydrolysates. Bruneton J.R.B.E. Vasudevan T.: Pharmacognosy: Nirali Publications.: A Textbook of Pharmacognosy. 11.C. & Robbers J. USA.R. & Nayak S.R. Wallis T. 4. Kokate C. Spray equipment & other accessories.K. Vasudevan T. Purohit A. & Turner T. Brain K.B. 14. & Laddha K. Brady L. Jalgaon. coating defects/problems · Film coating – Raw materials. Phytochemistry. Delhi. Bladt & Zgainski: Plant Drug Analysis: Springer Verlag. 2. Manipal.K. Medicinal Plants. Bristol. Jalgaon. Manipal. Kokate C. 7. · Q.S.C. Khandelwal K.: Photochemical Methods: A guide to modern techniques of Plant Analysis: Chapman & Hall. Pune.: Pharmacognosy. No.P.A. 13. coating columns (fluidized bed coating). & Evans W. cepa & A sativum) 11.B. structure and properties of sulphides from Allium species (A. 15. preparation and uses of gelatin.: Textbook of Pharmacognosy: CBS Publishers.: Pharmacognosy of Powdered Drugs: Manipal Power Press.N. Study of peptides.D. defects/problems · Enteric coating · Coating Equipments – Conventional & modified pans. coacervation 62 | P a g e 2.E.10.: Practical Pharmacognosy Technique and Experiments: Nirali Prakashan. London. Reference Books: 1. Aqueous film coating. 6. Harbone J. concepts of core & coat · Methods with equipments Wuster process.E. Tyler V. Saunders. proteins.G. 10. of coated tablets. 8. Microencapsulation · Definition. lyenger M. 7 .S. need/ reasons. 5. occurrence and uses of essential amino acids. Study of structure. & Gokhale S. Vrinda Publication House. Sources.. steps in detail. 1.: The Practical Evaluation of Phytopharmaceuticals; Wright.: Practical Pharmacognosy: New Vrinda Publishing House. . polyesters. “Pharmaceutical Pelletization Technology”. Deasy Patrick B. Rawlins.. purification. 21 ed. Ltd. polyolefins. properties desired. 1989. New York. Red cell cone. serum. Whole human blood. interfacial polymerization. th S.. exampleshydrolyzed gelatin based products. CBS Publishers & distribution. 4. Factor IX complex. Plasmapheresis. insulin injections (official) · Thyroid – Processing & product (official) · ACTH preparations · Oxytocin and vasopressin Reference Books: 1. 2. New York.. “The Theory and Practice of rd Industrial Pharmacy”.. catgut manufacturing & processing details. st Remington. Blood banking procedures. · Blood products Need. Q. Tutorial Pharmacy. Bristol.. th E. Marcel Dekker Inc. 1986. metallic wires.phase separation. Dextran (in detail) Glandular products · Insulin – extraction from pancreas. 3. Non absorbable types silk. Ballierwe Tindall. 6 Edn. linen.. Publications Pvt. Lachman Leon. Biological products · Sutures & Ligatures definition. PA. India. Cooper & Gunn. kanig Joseph L. “Microencapsulation and Related Drug Processes”. J. A. Albumin preparations. cone of platelets. aspects of blood products. 4 6 3 4 63 | P a g e . Mumbai. 5. Q.C. Taylor & Francis Ltd. The science and practice of pharmacy.. 7. multiorifice centrifugal process. pan coating. polyamides. 3.C. B. γ globulin preparations. 1995. Study of some fractions – clotting factors like Fibrinogen. Volume 37. Volume 20. testing of sutures & ligatures. Marcel Dekker Inc. 1984. Cole G “Pharmaceutical Coating Technology”. plasma. Fractionation of plasma. problems/ hazards. Lieberman Herbert A. classification. 3 Edition 1987. solvent evaporation. HETA starch. Vol I & II. spray drying and related processes. other absorbable sutures (brief). L. 1995.. Prothrombin. Varghese Publishing House. Isaac GhebreSellassie. Carter Ed.. 8 Edn.. 6. Ed. Bentley’s Textbook of Pharmaceutics. · Plasma substitutes (Plasma volume expanders) – need. 2005. AHF. Moore. hair colorants. Longman Singapore. pollution controlecological concern. face powder. edited by J. colors and other raw materials used in cosmetics. hair. · Protective preparationshand and body creams and lotions. formulation. lipstick. antilice preparations. · Miscellaneous preparations Introduction to depilatories shaving preparations. Wilkinson & R. face packs. hygiene.J. Publishers Pvt. 64 | P a g e .B. bleach cream. vanishing cream. foundation makeup. nail products. women’s and men’s hair dressing. and moisturizers. insect repellants. mouth washes and denture cleaners. · Hair care preparations shampoo. · Facial makeup products skin creams and lotions including cleansing cream. herbal cosmetics. antiperspirants and deodorants. 2 2 4. Structure of skin. 3. eye makeup. hair waving and straightening preparations. roage. tests to predict such reactions Microbiological aspects of cosmetics A brief review on perfumes.COSMETICOLOGY S. Topic Definition of cosmetics Historical background Classification of cosmetics and functions 3 hrs/ week Hours 1 2. bath oils. th Harry’s Cosmetology. tooth powder. 1. 7 Ed. 2 4 9 4 5 6 1 Reference Books: 1. baby cosmetics. Study of following cosmetics with respect to raw materials. hair rinses. barrier preparations and emollient preparations. processing and quality control: · Personnel hygiene products pedicure and manicure preparations. nails and skin appendages and interaction with cosmetics. Ltd. sunscreen and antisunburn preparations. cold cream. hair tonics and hair conditioners. 5. · Schedule S of drug and cosmetics Act in relation to cosmetic manufacture. dental care preparations including tooth paste.. No. Toxicology of cosmeticsirritation and sensitization reaction to cosmetics. stockist. a market share. Cosmeceuticals implants. Pricing policy Performance management Materials and Inventory management Vendor development. 4. Pricing analysis. preparations and Development. Core. (Lecturer 3) Role of product development and clinical research. 8. (Lecturer 3) Market research process. PRODUCT and PROMOTIONAL POLICIES. WHO requirements. Product and process environment Management. 6. Source of funds. Direct/ indirect. what is a market. (Lectures 3) Product Cost. chain of corporate retails outlets. 5. Hospitals. General awareness of Global requirements of MHRA/ MCA/ TGA/ USFDA/ ISO up gradation. value of a product.P. Balsam & Edward Sagarin nd Ed. 3. distributors. Vandana Publications Pvt. Market economics. Costs of inputs in a product. Health care industry positioning the pharmacist fit in the industry Major players. 3 hrs/ week 2. Wiley Interscience publications. Basic principals and types of viable Business and enterprise. Taxes. Change in offingmalls. Govt. Stock audits. competitive marketing. COST OUTPUT relationship.2. Clinical research. (Lecture 4) 65 | P a g e 3. cost benefit analysis of a product. Ltd. Six sigma concept. . PROFIT Management.. C & F agents. Product: DPCO. SWOT analysis of a product in competitive market. (Lecturer 6) Export market management: market search. basics of balance sheet and profit an loss account. 2 edition. Analysis of Volume and growth of Peripheral markets: Nutraceuticals.. Activity based costing. auxiliary and allied products and marketing. Manufacturing & Quality Control by P. 2005. Brands and Generic market. Major Diseases and major molecules. 7. (Lecturer 3) Marketing and sales: uniqueness of medical products marketing. Vol 1. wholesaler. Regulated and unregulated market requirements Continents and Countries for Global market. rd CosmeticsFormulations. Role of retail chemist. Sharma – 3 edition. major brands. IPR. Major Components of Pharma business (Lectures 3) Financial management. (Lecturers 3) Quality management: FDA regulations and approvals. Market forecasting process. ESIS schemes . patent registration. Cosmetics Science and Technology. NGOs. PHARMACEUTICAL MANAGEMENT 1.S.2 & 3 M. 1972./ Corporate purchasers. National budget. Topic Autonomic nervous system Brief introduction to Anatomy and Physiology of ANS Adrenergic agents (Sympathomimetic agents) adrenergic blocking agents Cholinergic drugs (Cholinomimetic agents e. Ashwathapa. Production & Operations Management by S.. Rajan Saxena. place. Firesafety and hazard management Hazaop study. Other regulatory requirements Factory Act. people.. Anticholinesterases) Antochoilinergic drugs a) Muscarrinic drugs b) Nicotinic blockers Drugs acting at neuromuscular junction (skeletal muscle relaxants) Drugs acting on autonomic ganglia (stimulants and blockers) Cardiovascular system Drugs used in the treatment of: Hypertension Congestive cardiac failure Angina pectoris Cardiac arrhythmias 66 | P a g e 3 hrs/ week Hours 18 2. Motivation. price. A. Introduction to Marketing Management by Adrian Palmer. Financial Management by Prasanna Chandra. (Lecturer 2) Reference Books: 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) th Marketing Management 12 edition by Kotler. 14 . (MSDS) safety data sheets. Loshy & Jha. Pollution Act.g. 1. Business Logistics/ Supply Chain Management by Ronald Ballon. PHARMACOLOGY III S. No. Production & Operations Management by K. Financial Management by I. Conflict management. Delegation. (Lecturer 3) 10. Personnel & Human Resource Management by Subba Rao. communication. Pandey. N. pace. Leadership. (Lecture 3) 11. M. Human Resource management by Ashwathapa. Organization ZS concept. Production & Operations Management by S. Chary. packing.9. Chunawala. nd Marketing Management 2 edition by Dr. Introduction to Supply Chain Management by Robert Hanfiels. Shop floor management. Management concepts that help to create value Ps: product. rd Gosh M. th Laurence D. Churchill Livingston 2003. 9. No. 2007.com) Demonstration a) effects of drug on isolated frog heart (CD’s/ actual) Adrenaline. th Rang & Dale Pharmacology 5 Edition. 2006. K. 8. S. 4. & Bennet Clinical Pharmacology 9 Edition. 1. for infusion over a given period of time) * Indian Journal of Pharmacology. Goodman & Gilman’s Pharmalogical Basis of Therapeutics – Joel G. Feb. S. 2005. 3. Fundamentals of Experimental Pharmacology. infusion including cannulation. New Delhi. The McGraw Hill Companies Inc. Ach/ Histamine) using a suitable isolated tissue preparation. 7. rd Lippincott’s Illustrated Review Pharmacology Lippincott Raven 3 Edition Howland & Nyeets Publishers N Y. b) L V infusion a simulated model using rubber tube mounted on a wooden board (the students are taught to calculate the dose and concentration to be used. Handbook of Experimental Pharmacology 3 Edition Vallabh and Prakashan. 5. rd Kulkarni. . 2004. Pharmacology & Therapeutics 20 Edition. Lee th E. Alfred Goodman Gill Man 11 Edition. setting of drop rate. Appleton and Lange publication. 2006. Calcutta. Popular Prakashan. setting of L V. Katzung Basic and Clinical Pharmacology 9 Edition. Limbird. (Free Full text available at www. Hilton & Company. th Lewis Pharmacology By Crossland 5 Edition. Bhandarkar S D & Rege N. N Y. N. R. 2. N. 2001. Diuretic drugs 6 Reference Books: 1. Topic 4 hrs/ week Hours Experiments a) Dose Response Curve (DRC) of any agonist (eg. PHARMACOLOGY LABORATORY I S. Elsevier.Drugs used in the treatment of hyperlipoproteinaemia 3.jiponline. th B. 2007: 5759. 6. G. R. Vol 39 (I). K on isolated heart Effect of digitalis on hypodynamic heart b) Stimulated experiment (CD’s) Expharm effect of drug on eye effect of drug on GI motility c) Demonstration with the help of CD’s or Kymograph recordings 67 | P a g e 2. Acetylcholine Atropine Propranolol Effect of excess of calcium and potassium on isolated heart Effect of lack of Ca. 2005. 3 Edition. Churchill Livingstone. Hardman. actual dilution for preparation of infusion. th Satoskar. No. 1. black catechu and Kino) 68 | P a g e 2. vein islet number. 2. A Handbook of Experiments in PreClinical Pharmacology. rice. 2006. 1970. eg. Tutorials Laboratory Animal Handling Care and Ethics in Animal experimentation. L. c) Histochemical identification of starches (maize. Effect Neostigmine on DRC of Ach Effect of Panecuronium on DRC of Ach (Give the reading to the students and ask them to plot the graphs and draw the conclusion from the results. 41 (1). 2007; 5261 (www. Identification of unorganized drugs by chemical tests (agar. Hilton & Company. Pharmacological Experiments on Isolated Preparations. 4. Handbook of Experimental Pharmacology. b) Determination of %purity of ginger powder. potato) Identification and Measurement of dimensions of different types of starch grains and calcium oxalate crystals. 3 Edition Vallbh Prakashan. Leaf constants – Stomatal index. Edinburgh & London. acacia. Career Publications. palisade ratio. Perry. Kasture. Determination of alcohol soluble and water soluble extractives. Topic 4 hrs/ week Hours 3 Quantitative estimation by lycopodium spore method a) Determination on number of particles (starch grains/ stone cells/ lignified fibers) in given sample of crude drugs. N. K. Fundamentals of Experimental Pharmacology. st S.ipper. trichomes and stomata. 3. stomatal number.org ) PHARMACOGNOSY LABORATORY I S. 3. sterculia. 2005. 1 . 2 Edition. gelatin. New Delhi. S. M. rd Gosh M. 1 3 3 5. Reference Books: 1. nd W. 2005. E & S Livingstone. tragacanth. total ash value and acid insoluble ash and water soluble ash value for any one crude drug as per I. Websites: Indian journal of Pharmaceutical education and research. 4. B. 1 Edition. Calcutta. veinlet termination number. 3 Edition. competitive and non competitive Find out the potency of the drugs by studying the DRC by studying IC 50 values) A Calculation of P 2 value for atropine using Ach as agonist. Identify type of antagonism existing between two drug by studying the nature of the graph. Vol.P. JanMar. rd Kulkarni. pale catechu. wheat. 3. Nail care products · Nail Lacquer · Nail Lacquer remover 7. Skin moisturizers · Cold cream · Hand and body lotion · Moisturizing lotion 3. Suncare products · Medicated dusting powder · Sunscreen cream 4. Herbal cosmetics · Powder face scrub · Antiwrinkle cream · Antiacne cream 69 | P a g e . Shaving preparations · Lather shaving cream · Brushless shaving cream · Aftershave lotion 8. 1. Detection of adulterants fixed oils Visit to medicinal plant garden Total 1 2 14 COSMETICOLOGY LABORATORY 4 hrs/ week Formulation – Processing.6. Dental care products · Tooth paste · Medicated toothpaste · Mouthwash 9. Hair care products · Clear liquid shampoo · Antidandruff shampoo · Men’s hair dressing preparation 6. Skin cleansers · Cleansing milk · Clear cleansing gel 2. Packaging and Evaluation of cosmetic preparations. Facial cosmetics · Vanishing cream · Foundation lotion · Eye shadow · Lipstick 5. 7. 70 | P a g e 9 3 hrs/ week Hours 2. propylhexedrine. xylometazoline. camsylate. nimodipine. isopropamide iodide. chemistry. pentaerythritol tetranitrate. tocainide. bepridil. guanethidine*. amlodipine. diltiazen. bethanechol. ipratropium bromide); synthetic cholinergic antagonists (cyclopentolate*.tacrine*. generic names. candersartan) (iv) Vasodilators and Kchannel agonists (diazoxide. mexilitine. valsartan*. amiodarone. terbutaline*. carbochol*. gallamine. sotalol*). 1. disopyramide. mecamylamine) (v) Neuromuscular blocking agents (tubocurarine. isosorbide dinitrate. gemfibrozil. introduction to rational development if any of the class of drugs. metoprolol. phentolamine. scopolamine. SAR. CVS Drugs: (i) antianginal agents (amyl nitrite. procainamide*. Topic Discussion of the following classes of drugs including classification. pseudophedrine. atenolol. 9 3. verapamil. doxazosin) (iv) βadrenergic antagonists (propranolol*. (iii) Antihypertensive agents (a) review of adrenergic agents (b) review of Ca channel blockers (c) ACE inhibitors (captopril*. structure including stereochemistry. PHARM SEMSETER VII PHARMACEUTICAL MEDICINAL CHEMISTRY – III S. minoxidil) (v) Antihyperlipidemic agents (clofibrate*. diltiazem. lidocaine. ambenonium chloride. albuterol. succinyl choline chloride) Adrenergic Drugs: (i) αadrenergic agonists (phenylephrine. naphazoline. isofluorphate. pralidoxime) (iii) Cholinergic antagonists (atropine. neostigmine*. oxymetazoline. dipyridamole) (ii) antiarrhythmic agents (quinidine. triethiodide. ephedrine. metabolism. prazosin. timolol. procyclidine hydrochloride. lovastatin. acebutalol. alprenolol. No. Cholinergic Drugs: (i) cholinergic agonists (methocholine. isoxsuprine. salmeterol. clonidine*. methyldopa. labetalol*) other adrenergic agents (amphetamine. benzepril. nifendipine*. guanfacine ) (ii) βadrenergic agonists (isoproternol. ritodrine) (iii) αadrenergic antagonists (tolazine. reserpine). enalapril. ramipril) (d) angiotensin II receptor antagonists (losartan. molecular mechanism of action and synthesis. pro[afenone. physicochemical properties. homatropine hydrobromide. chemical nomenclature. dicyclomine*.SYLLABUS COPY FOR FINAL YEAR B. ben/otropine mesylate. tropicamide) (iv) Ganglion blocking agents (trimethaphan. guanabenz. verapamil. propranolol. 4 4 6 1 . niacin. pilocarpine) (ii) Ach esterase inhibitors (physostigmine. encainide. phenoxybenzamine. ion exchange resins. A. 2007. external standard. Kleeman and T. columns and fittings (for reverse and normal phase. direct sample introduction. Wiley. Column efficiency and band broadening (shape of peakGausssian. Lemke and D. pumps (reciprocating. (UVsingle wavelength. Williams. Daniel Lednicer. retention time. New Age International Publishers. 1. 4 Edition. flame ionization. 4. Injection systems (Rheodyne injector in detail. John H. Eds. head space analysis.atorvastatin) * Indicates synthesis to be discussed Reference Books: 1. phtotodiode array). mobile phases. electron capture. Gas chromatography (GSC &GLC) Introduction. fluorescence. disadvantages. column packing). th Medicinal Chemistry. Quantitative analysis (Peak height. H. selective factor. thermionic. Pharmaceutical Chemistry. isocratic elution. The Organic Chemistry of Drug Synthesis. HPLC Introduction. 2002. electrochemical. 2007. Optimisation of column performance (Column resolution. Vol. adjusted retention time). Ashutosh Kar. Beissewenger. The Art of Drug Synthesis. terminologystationery phase. 1988. Qualitative analysis. tailing factor. van Deemeter equation). gradient elution). refractive index. peak areas. photoionisation). Douglas S. classification of chromatography methods. 3 Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry. sampling loops). Rate of solute migration (capacity factor. No. Instrumentationmobile phase reservoir. detectors advantages. 4. plate height. 5. disadvantage. number of theoretical plates. Beale. area normalization). Ion exchange chromatography Principal. migration rate of species (partition coefficient. columns. solvent treatment system. Baltimore. J. applications of Thermal conductivity. Eds. Lippincott Williams & Wilkins. applications. Topic 3 hrs/ week Hours 3 Chromatography Principal’s. 3. A. Vols 1 to 7. 2004 Foye’s Principals of Medicinal Chemistry. calibration and internal standard. Thermostats. Ellis Horwood Ltd. Eds. selectivity factor). injection system. capacity factor. Principal. Roth. 2. nitrogen phosphorus. Principal. 71 | P a g e 2. detectors (advantage. pneumatic. 2 . peak width). th 11 Ed. applications. variable wavelength. 6. EDrug Synthesis Eds. mobile phase. Instrumentationcarrier. displacement. Williams & Wilkins. Johnson and Jie Jack Li. L. analytical and guard columns. PHARMACEUTICAL ANALYSIS IV S. Wiley Interscience. Block and John M. 5 3. T. methods of statistical analysts as applied to sampling and interpretation of results. th Willard H. applications Paper chromatography Introduction. applications Size exclusion chromatography Principal for gel permeation and gel filtration method. DeanInstrumental Method of Analysis 6 edition. 4. U. Browning Chromatography.P. factors affecting retention factor. ascending. 1992. CBS Publishers & Distributors. Sampling procedures Objectives. th Beckett & StenlakePractical Pharmaceutical Chemistry. H. sampling equipments. 1969. preparative TLC. sample application. applications) High performance thin layer chromatography Introduction.S. applications. confidence limits. Ftest. development techniques (descending. instrumentation. Quantitative evaluation (Area. multiple development two dimensional development.P. I. sampling plan. 12. preparation of plates. solvents. different absorbents different methods for preparation of plates. Differential Scanning Calorimetry (DSC). mobile phases. different kinds of samples. 10. India. B. qualitative analysis location of spots. twodimensional chromatography). L. applications. 13. sampling schemes. 3 8. 4 edition. densitometry elution factors affecting RF. horizontal. Merrit & John A. 2.S. Quantitative analysis (direct and elution method). Reference Books: 1. ttest. Differential thermal analysis (DTA). factors affecting analysis. radial multiple chromatography. solvents. Principal.. Mc Graw Hill. pharmaceutical applications of: Thermogravimetry (TG). Quantitative evaluation Instrumentation (adsorbents. Statistics & Statistical Quality control Normal distribution. development techniques cascending. Saunders College Publishing.. 4 edition. 6. Validation of analytical methods as per U. development techniques Qualitative evaluation. 1988. support media. 1 1 7. 3 9.5. 72 | P a g e . linear regression correlation coefficient. Qualitative evaluation visualization of spots. Ion pair chromatography Principal. choice of filter papers. introduction. 3.P. 5. L. Thermal methods of analysis Theory. weight. New Delhi. Principal. 11. USA.. solvents.P. CBS Publishers & Distributors. descending. 1986. scanning and documentation). European Pharmacopeia. London. chromatographic chambers. Thin layer chromatography Introduction. 1 3 3 5 th SkooghPrincipals of Instrumental Analysis. No. ashwagandha. Biosynthesis of lysergic acid. ipecac. Colchicum. MunsonPharmaceutical Analysis. hydrocotyle. ginko biloba. PHARMACOGNOSY III Drug mentioned in bold are or detailed study S. vasaka. onion. gentian. bromelain. tinospora. opium alkaloids. 6 2 2 3. cochineal. chalk. hyoscyamus. momordica. hyperieum. urokinase. kurchi. Detailed study of the following plants containing alkaloids Ephedra. 4. Tyler V. marigold. apricot. cascara. amla.6. ashwagandha. datura stramonium. classification (inhalant. spirulina. alkaloids. hibiscus. belladonna. gymnema. Plants causing hay fever & dermatitis. honey. 3 5. mould causing allergy.C; Textbook of Pharmacognosy; W. fenugreek. arnica. Modern methods. tobacco. wild cherry d) Napthoquinone Plumbago. bentonite. 3 6. alkaloids. preparation and uses of following enzymes: Papain. Topic 3 hrs/week Hours 12 Alkaloids: Chemistry. composition. juglone. talc.; Pharmcognosy; Lea Feibger. vinca. 2. henna. cinchona. 73 | P a g e . E. Occurrence structure and applications of following Glycosides a) Anthroquinone Rubia. curare. Classification and occurrence of alkaloid in general. colchicines. Marcel Dekker Inc. hops. Sources. alkanna. chamomic. 2. coca. malt extract. USA. & tea. Trease D. aconite. Preparation of polyvalent antivenins Study of following herbs as health food (Neutraceuticals): Alfaalfa. Brady L. rauwolfia. bran. James W. E. ergot. pepper. Brief introduction to Plant allergens Definition. Study of sulphur containing naturally occurring compounds (sulphide. streptokinase. lobelia. pits. Occurrence. garlic. emethine. andira. thiophenes). walnut Biosynthesis of aloe emodin. tropane. chicory. 2 Reference Books: 1. & Evans W. B. 1981. Ginseng. opium. R. cola. quinine. cocoa. aloes. b) Isothiocyanate Brassica c) Cyanogenetic Almonds. senna. & Robbers J. Saunders. infestants etc. USA. serratiopeptidase. preparation and uses of following drugs of mineral origin: Diatomic. 1. rhubiarb. coffee. nux vomica. injectant. pepsin. Study of lectins and snake venom. cucumber.) with example. amygdaline. pilocarpus. concept of FFS. Bruncton J. Textbook of Pharmacognosy; CBS Publishers. 8 3. R. Delhi. Pharmacognosy: Nirali Publications. K. E. additives. K. A. particle size for suspension. Lyenger M. Kokate C. N. Jalgaon. freeze drying . Pharmacognosy of Powdered Drugs: Manipal Power Press. 4. Lyenger M. vehicle. Laddha K. Khandelwal K.: Practical Pharmacognosy: New Vrinda Publishing House. · Contact lens solutions: types of lensescleaning solution. Vrinda Publication House. Jalgaon. leaker test. 1. disinfection solution. D. B. S. multipurpose solutions and packages. 6.: Practical Pharmacognosy Techniques and Experiments: Nirali Prakashan. pyrogen/ endotoxin test. Bristol. facilities layout. A textbook of Pharmacognosy. pyogens. tears. Kokate C. HEPA filters. personnel. 10. 14. Vasudevan L. rubber closures and testing. S. vehicles other than WFI. Bladi & zagainskit: Plant Drug Analysis: Springer Verlag. Pune. QA & QC sterility test. purity. Purohit A. environmental control cleanliness classes. A. Pharmacognosy. clarity. Vallabh Prakashan. B. & Gokhale S. P.3. Harbone J. 5. 13. 15. biopharmaceutical consideration and 74 | P a g e 2. & Buddha K. Phytochemical Methods: A guide to modern techniques of Plant Analysis Chapmann & Hall. Phytochemistry. The Indian Pharmacopeia. 9. Practical Pharmacognosy. preservatives and efficacy test. Manipal. The Practical Evaluation of Phytopharmaceuticals Wright Sceintica. 12. Medicinal Plants: Intercept Limited. 8 . & Nayak S. & Furner L. N. cornea. Wagner. G. Anatomy of Crude Drugs: Manipal Power Press. air handling (HVAC systems). laminar flow. particulate evaluation. No. 8. 11. lubricants. Manipal. Wallis I. The Controller of Publication Delhi. types of ophthalmic products solutions. Pune. ophthalmic ointments and gels. ocular bioavailability. types of formulations. Topic 3 hrs/ week Hours 12 Introduction to sterile dosage forms Parental products · Various routes of parental administration. precorneal tear film. suspension. QA and QC sterility test. Vasudevan I. production procedures. Oral sustained and controlled release systems · Advantages of SR systems. London. WFI preparation. PHARMACEUTICS VI S. packaging. storage and distribution. additives in parental products. 7. containers glass and plastics types and evaluation. R. Ophthalmic products · Anatomy and physiology of eye – lachrymal system. tests on ointments and collapsible tubes. Brain K. Emphasis on the importance in drug discovery. 2 ed. Theories of dissolution. by M. ed. by Kenneth A. Physiology of GH and oral bioavailability Formulation. 3. Leon Lachman and H. physiology of cell membrane and passage of drugs across cell membrane. oxidation . 4 ed. limitations and advantages equation. Mitra.. nd Pharmaceutics The Science of dosage form design ed. 9.g. 29. introduction to ICH guidelines. rd Liberman.dose calculation of drug. insulin zinc suspension Dissolution rate and methods of enhancing dissolution rate. I. 4. Rate limiting steps in drug absorption. 1987. photolytic degradation. Quality Control of Parenterals. 1985.. Sterile Dosage forms. A. H. Pharmaceutical dosage forms: Parental medications. Liberman. Ltd. th Modern Pharmaceutics. Marcel Dekker Inc. Rhodes. A. ion exchange controlled systems. by Leon Lachman. ed. dosage form related factors and physiological factors affecting oral bioavailability Different routes of drug administration as alternative to oral route Factors affecting bioavailability of drugs from parental routes e. I. Kanig. 7. Aulton. 21 ed. Avis. by Ashim K. 5.. Stability studies · Kinetic principles. Marcel Dekker INC. development and clinical pharmacy. Definitions. Marcel Dekker INC. Robinson Joseph R. Marcel Dekker Inc. E.. Marcel Dekker “Controlled drug delivery – Fundamentals and Applications”. Revised and Expanded ed. II. 3 Edn. Churchill Livingstone.. Michael J.. matrix and reservoir type of systems. diffusion controlled systems. 8 Reference Books: 1. 1986. Modified pH partition theory and its limitations. 6. Banker and Christopher T. ed. The theory and practice of industrial pharmacy. Philadelphia. 2. 2005. Physicochemical factors affecting the bioavailability of drugs.. L. 4. properties of drug with reference to the design of oral SR systems. dissolution controlled systems. The science and practice of Pharmacy. 2002. Akers. BIOPHARMACEUTICS AND PHARMACOKINETICS Topic 3 hrs/ week Hours 1 2 2 2 2 2 2 Introduction to the subject of biopharmaceutics and Pharmacokinetics. I and II. Lee Vincent H. 8. methods to enhance stability studies. 1993. st Remington.. Lea & Febiger. different mechanisms of drug transport. Vol. 3 ed. Zero v/s first order transport. degradation pathways hydrolysis. Vol. J. by Gilbert S. III. Arrhenius equation and derivation of shelf life based on Arrhenius equation. B. Vol. rd Turco and Kings. Ophthalmic drug delivery. Publications Pvt. Application to different dosage forms 75 | P a g e . Verghese Publishing house. Official and unofficial methods of dissolution.. 2002. . th Milo Gibaldi. Baverly Books Pvt. Ltd. perfusion limitation permeability limitation. 1. Notari. “Clinical Pharmacokinetics: Concept and rd Application”. USA. Clearance. “Biopharmaceutics and Pharmacokinetics An Introduction”.In vitro in view correction and its significance Distribution Definition relationship of drug transport to distribution process. 2005. 1992. New York. half life. 1995. 3. Andrew B. 1971. Importance of volume of distribution. first pass effect and dependence of hepatic extraction ratio. Plasma protein and tissue protein binding. Elimination. introduction to the concept of volume of distribution and factors affecting distribution. Brahmankar. Malcom Rowland. Definition. Marcel Dekker Inc. elimination rate constant. 6. A LeaFebiger book. introduction to elimination via metabolism and excretion Hepatic clearance drugs. Singapore. 5. Introduction to method for estimating bioavailability and bioequivalence. “Pharmaceutical Dissolution Testing”. Volume 49. Marcel Dekker Inc. Topic Drugs acting on central nervous system · Aliphatic alcohols · General anaesthetics · Local anaesthetics · Sedativehypnotics & anxiolytic agents · Antidepressants · Antipsychotics 76 | P a g e 3 hrs/ week Hours 18 . bioavailability. Application of PK principles through simple problems. Yu. C. Introduction to the compartmental open model and its assumptions. 1 Edition. th Robert E. M. PHARMACOLOGY IV S. Introduction to renal clearance and factors affecting renal clearance. Banakar. “Biopharmaceutics Clinical Pharmacokinetics” 4 Edition. Jaiswal. Susanna WuPong. New York. L. 4 Edition. Reference Books: 1. No. Sunil B. 1996. 2. B. D. Pharmacokinetics: Introduction to compartmental and physiological models. absorption rate constant. “Biopharmaceutics and Pharmacokinetics: a st treatise”. the trapezoidal rule and the method residuals Introduction to the rate method and sigma minus method for urine analysis for IV. Leon Shargel. Discussion of linear and nonlinear kinetics and description of factors resulting in non linear kinetics. Umesh.. USA. Mathematical treatment of Pharmacokinetics upon IV bolus dosing and extravascular dosing. Delhi. 1 3 3 1 9 2 2 2 4.. 3 Edition. Vallabh Prakashan. Thomas Tozer. Introduction of the concept of area under the curve. “Applied Biopharmaceutics & th Pharmacokinetics” 5 Edition. 1991. Signaling Pathways for activation and inhibition. 3 Edition. Popular Prakashan. Antithistaminics 5 HT and Antagonists Kinins. Vallabh Prakashan. S. Handbook of Experimental Pharmacology. Hardman. 1. G. Bhandarkar S. 4. D. rd Kulkarni. Psychomotor stimulants and Psychotomimetic drugs) 6 2. R. Limbird. th B. Churchill Livingstone. th Laurence D. 2 6 5. – Fundamentals of Experimental Pharmacology. Cytokines. Immunology of diseases like HIV and Cancer and their modulation & Immunomodulators. rd Lippincott’s Illustrated Reviews: Pharmacology – Lippincott Raven 3 Edition Howland & Nycets Publishers N Y. 2005. No.. Goodman & Gilman’s Pharmacological Basis of Therapeutics – Joel G. Katzung Basic and Clinical Pharmacology 9 Edition Appleton and Lange publication. th Rang & Dale Pharmacology – 5 Edition. 3 Edition. N Y. 4. Elsevier. 5. th Satoskar. 2003. antipyretic and antiinflammatory drugs CNS stimulants & Psychotomimetic drugs (Convulsions and respiratory stimulants. S. 2006. 6. Churchill Livingstone. 8. Pharmacology & Therapeutics 20 Edition. Alfred Goodman Gillman 11 Edition. 2.· · · Drugs used in Neurodegenerative disorders Antiparkinsons Drugs used in Alzheimer’s disease Analgesics. 2001. 7. 2007. Autocoids Histamine. PHARMACOLOGY LABORATORY II S. Hilton & Company. 4 Reference Books: 1. New Delhi. Calcutta. & Bennet Clinical Pharmacology – 9 Edition. PAF Pharmacotherapy of Bronchial asthma Immunology – Regulation of Immune system physiological and pathological states. & Rege N. N. Principals of toxicology Heavy metal poisoning and its treatment Pesticide poisoning and its treatment Opium alkaloid poisoning and its treatment 3. Experiments Bioassay of Acetylchoine 77 | P a g e Topic 4 hrs/ week . 2004. th Lewis Pharmacology – By Crossland – 5 Edition. The McGraw Hill Companies Inc. rd Gosh M. Ecosonides. th Lee E. 3. 2006. R. 2005. 9. N. K. 2. (www. M. W. Fundamentals of Experimental Pharmacology. Analgesic effect of asprin using analgesiometer To study phenothiazine induced catatonia in rats and to study anticatatonic (antiparkinsons) effect of scopolamine To study the anticonvulsant property of diazepam on pentylene tetrazole induced convulsions in mice or anticonvulsant effect of phenytoin against maximal electroshock induced convulsion in mice Toxicity studies (CPCSEA. Career Publications. 8. 3. Hilton & Company.org ) PHARMCEUTICAL CHEMISTRY LABORATORY – II 1. S. Holfmann rearrangement: Anthranilic acid from Phthalimide. 4. 41 (1) Jan Mar. K. Multistep reaction: Sulfanilamide from acetanilide. 6. Vol. st S. A Handbook of Experiments in PreClinical Pharmacology 1 Edition. 2006. N. 3 Edition. Condensation: Phenytoin. 4 hrs/ week Synthesis of heterocyclics: a) Benzimidazole from 0phenylenediamine. 2bnd Edition. 2007; 5261. B. Kasture. 1970. E & S Livingstone. 5. 2. L. 7. Websites: Indian Journal of Pharmaceutical education and research. 9. Perry. Histamine Demonstration bioassay of oxytocin bioassay of pancuronium (With Graph or Actual) Demonstration/ Simulated CD’s To study the CNS depressant activity of chlorpromazine on locomotor activity of mice using actophotometer To study the effect of diazepam on the muscle grip strength of mice using rotarod apparatus. 4. Benzilic acid rearrangement: Benzilic acid from benzyl.ipper. Reference Books: 1. 2. Edinburgh & London. OCED guideline) brief introduction to acute. Perkin reaction: Cinnamic acid from benzaldehyde Claisen/ Aldol Condensation acid from benzaldehyde. 5. 2005. 4. 3. rd Kulkarni. Esterification: Benzocaine from PABA. 3. Handbook of Experimental Pharmacology – 3 Edition Vallabh Prakashan New Delhi. rd Gosh M. Pharmacological Experiments On Isolated Preparations. 78 | P a g e . b) 4methyl carbostyril from Acetoacetanilide. Reduction reaction: PABA from p nitrobenzoic acid. Calcutta. subacute and chronic toxicity studies. 2005. 2. rauwolfia. kurchi. 2 12 PHARMACEUTICS LABORATORY IV 1. microscope and chemical test for identification of cinchona. nux. No. 1. · · · · · Preparation and monographic testing WFI (IP) Processing & testing of glass containers & rubber closures (as per IP) Preparation and documentation of following: A) Injections (official) Sodium chloride and Dextrose injection Calcium gluconate injection Ascorbic acid injection One injection with oily vehicle One suspension injection B) Ophthalmic preparations Sulphacetamide eye drops One Antibiotic eye ointment Contact lens solution Calculation of Pharmacokinetic parameters (plasma samples provided) · · · 4. 79 | P a g e . 2. senna. vasaka. Topic 4 hrs/ week Hours 8 2 Morphology. 3. ephedra. datura. TLC analysis: 1) Alkaloids of nux vomica cinchona 2) Glycosides of senna/ aloe Morphological identification of drugs covered in theory (alkaloids and glycosides) any 20 samples Total 3.PHARMACOGNOSY LABORATORY II S. ipeca. vomica. zopiclone) 2. paroxetine. * indicates synthesis to be discussed 5 3 hrs/ week Hours 5 5 1 5 2 7 2. nabumetone. Midazolam. Metabolism. chlordizepoxide. Topic Discussion of the following classes of drugs including. diazepam. ibuprofen. phenylbutazone*. isocarboxazide. Anticonsulvants (Phenobarbital. SAR. CNS Drugs 1. tranylcypromine) 6. gluthethimde*. Oxazepam. molindone 4. carbamazepine*. dextromethorphan. Antianxiety agents (meprobamate. trihexyphenidyl. physicochemical properties. fluoxetine*. clonazepam*. sodium valproate. hydroxyzine. haloperidol*. introduction to rational development if any of the class of drugs: 1. PHARM. naloxone. Alprazolam. SEMESTER VIII Pharmaceutical Medicinal Chemistry – IV S. tybamate. thioridazine. chlorimipramine. 6 80 | P a g e . levodopa. bromocriptine. rofecoxib. naproxen*. sulindac. vigbatrin 3. zolpidem. fentanyl. piroxicam*. levophanol. clozapine. sulfinpyrazone. pheniridine. generic names. anileridine. paramethadione. Sedatives and hypnothics (mephobarbital. pargline. progabide. paracetamol. diclofenac*. Analgesics (opioids) (morphine. methadone*. racemoramide. dextropropoxyphene*. Phenobarbital pentobarbital. chemical nomenclature.SYLLABUS COPY FOR FINAL YEAR B. ketoprofen. triflupromazine. trimethadione. structure including stereochemistry. codeine. Antidepressants (imipramine. lamotrigine. allopurinol). molecular mechanism of action. primidone. nalorphine. orphenadrine) 7. cholorodiazepoxide. procyclidine. and synthesis. colchicines. nitrazepam*. naltrexone) NSAID’s (aspirin. phenazocine. nimesulide. pimozide. celecoxib. risperidone*. pentazocine. No. amantadine. amitryptyline. loxapine. ethosuximide*. oxyphenbutazone. diazepam. benzotropine*. phenadoxone. meperidine*. fluphenazine. phenosuximide. selegiline. classification. nortriptyline. chlorprothixene. indomethacine. trazodone. droperiodol. Antiparkinsons (carbidopa*. α and βprodine. Antipyschotics (chlorpromazine*. doxepine*. chemistry. iproniazid. mefenamic acid. choral hydrate. phenytoin. secobarbital. buspirone) 5. John H Block and John M Beale.Reference Books: 1.g. applications. 4. theory. solvents used in NMR (Choice of solvents. anisotropic effect. 2.. HPLCMS). Roth. Phenomenon (Spinning nucleus. Pharmaceutical Chemistry. precessional motion. 3. Topic 3 hrs/ week Hours 3 1. alkanes. spinspin decoupling. advantages and disadvantages. and T. Mass spectrometry Introduction. Instrumentation (single focusing and double focusing mass spectrometer. 2007. flame structure. Flame atomization (types of flames. Wiley Interscience.. single and double beam spectrophotometers. magnetic field sweep. L. 2002. Eds. e. Vols. Basic principles. The Art of Drug Synthesis. New Age International Publishers. hydrogen bonding effects). Electron impact. 4 Edition. Pharmaceutical applications. carbonyl. base peak. quadrupole mass spectrometer GCMS. 2004. 1 to 7. Wiley. Eds. T. 81 | P a g e 6 6 5 . 1: Drug Synthesis. th 11 Ed. th Medicinal Chemistry. Applications. Vol. decay. recorder and integrators. PHARMACEUTICAL ANALYSIS V S. of signal. Fragmentation processes. radioactive. 1988. Ashutosh Kar. Beissewenger. solvent shiftsconcentration. H. alkenes. Williams. 4. flame atomizers). The Organic Chemistry of Drug Synthesis. effect of an external magnetic field. Isotope. receiver. Nuclear Magnetic Resonance Spectroscopy Introduction. theory. Williams & Wilkins. Molecular ion. coupling. radiofrequency oscillator.. Ellis Horwood Ltd. Kleeman. fast atom bombardment spectrometry). Vander Waals deshielding. A.. Lemke and D. Baltimore. 2. Instrumentation Radiation sources. temperature. chemical and magnetic equivalence). energy transitions). metastable ions. 3. Eds. chemical ionisation. 6. Spinspin coupling constants and splitting (splitting of NMR signals. constants. Eds. Douglas S Johnson and Jie Jack Li. 5. aromatic and cyclohexane). Atomic absorption and Emission spectroscopy Principle. J. No.. A. Foye’s Principles of Medicinal Chemistry. 2007. deshielding. difference between atomic absorption spectroscopy and flame emission spectroscopy.. multiplicities. Lippincott Williams & Wilkins. Chemical shift and its measurement (factors influencing chemical shiftshielding. Instrumentation (Magnets. Daniel Lednicer. Field ionisation mass spectrometry. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry. precessional frequency. Radiochemistry and Radiopharmaceuticals Fundamentals of radioactivity (radionuclide. liquid scintillating counting.. Structural elucidation problems based on UV. gamma scintillation detector). 3. U. P. IR. Curie). 1992. dioscorea.halflife of radionuclide. Reprinted 2005. Principles. Near IR spectroscopy Introduction. Quantitative absorption Absorbance measurements. Reference Books: 1. ginseng. Isotope dilution analysis. USA. Sample interface. measurement of radioactivity (Geiger Muller counter. 1987. chemical properties). London. New York.. quillaia. Clive WhistonAnalytical Chemistry by open learning. 1969. smilax Acacia concinna. rd William KempOrganic Spectroscopy. European Pharmacopoeia. alpine.. Hyphenated TechniquesGCMS. Radiation protection. Merritt & John DeanInstrumental Method of Analysis. th SkooghPrinciples of Instrumental Analysis. S. diffraction methods. radionuclide purity and radiochemical purity). Pharmaceutical analytical applications. bacopa. H. Qualitative measurements NIR overtone bands of organic functional groups. th Beckett & StenlakePractical Pharmaceutical Chemistry. Wavelength selection. CBS Publishers & Distributors. John Wiley & Sons New York. Properties of radiation. No. 4 edition. 3 edition. CBS Publishers & Distributors.P. NMR. Detectors. 1988. P. Radiopharmaceuticals (Properties of radionuclide. hydrocotyle. Mass spectroscopy (simple problems with molecular formula given). 6. I. India. L. Bragg reflections. specific activity. Sample preparation. Bccquerel. B. fenugreek. 8. Topic 3 hrs/ week Hours 6 1. 5. asparagus. diffuse reflectance measurements. pharmaceutical applications of NIR. 99m Tc generator. 3 3 8 2 PHARMACOGNOSY IV S. 7. Instrumentation Radiation source. agave. 1986. Quality control of radiopharmaceuticals (Physical. identification of crystalline compound. chemical and sterility control. Browning Chromatography. LCMS (Interfaces and Applications only). 2. th Willard H. Instrumentation.. Palgrave Publishers Ltd. Advantages. 4. pharmaceutical properties. Saunders College Publishing. 5. 4 edition. Xray powder diffraction. 6 edition.. sapiandus) 82 | P a g e . L. 6. India. Glycosides Saponin glycosides (liquorice. Toronto. 7. McGraw Hill. XRay methods Introduction. 4. Introduction to marine Drugs Cytotoxins with any two examples. & Robbers J. mushrooms. asafetida. Phytochemistry. Wallis T. ajowan. star anise. balsams (tolu. shellac. Reference Books: 1.: Pharmacognosy. poison ivy. 5. 2. nerium. phyllanthus 6. 10. Brady L. Polyketides – male fern. coriander). USA. Phytotoxins Abrus precatorius. lily of the valley. curare. jatamansi. peru). cardamom. 6. 4. tinospora.: Textbook of Pharmacognosy; CBS Publishers. rose. composition & preparation of volatile oils and uses.: Pharmacognosy; Lea Feibger. belighia sapida. E. B. cinnamon. rasana. & Evans W. Flavonoids Quercetin. strophanthus. aconite. Preparation and Evaluation of plant extracts and formulations with respect to phytoconstituents. Volatile oils: with respect to sources. Saussurea lappa. eucalyptus. yew. 5. & Gokhale S. Delhi. K. fennel. Vasudevan T. Kokate C. 11. E. & Laddha K. spearmint oil and peppermint oil. cannabis hops. Rutin. 2. colocynth. London. palmrosa. Vrinda Publication House. chirata. Terpenoids & iridoids (Structure. B. benzoin. S. squill. lemongrase. psoralea. abolmescus. guggulu. caraway. lemon peel oil. orange peel oil. C. winter green. occurrence and uses) Quassia. 3. clove. Trease D. di and triterpenoids) (skeleton only) 9. Artemisia. gentian. Harbone J. valerian. Jalgaon 83 | P a g e 9 4 2 2 1 4 2 2 2 2 . 3. 7. taxus. nutmeg. poison hemlock. E.: Phytochemical Methods: A guide to modern techniques of Plant Analysis: Chapman & Hall. andrographs 8. datura.. dill. Umbelliferous fruits (anise. (Colophony. guaiacum. patchouli oil.Cardiac (digitalis. Biosynthesis of terpenoids (mono. thevetia) Biosynthesis of steroidal glycoside molecule. R. Pune. Resins turpentine. Phenylpropanoids & Lignans Podophyllum. capsicum. Saunders. P. Medicinal Plants; Intercept Limited. piccrorhiza. Special aspects of preparation of Ayurvedic formulations and herbal formulations. Purohit A. psoralea. artmesia.: A Textbook of Pharmacognosy. Ammi majus. B.: Pharmacognosy; Nirali Publications. Bruneton J. ergot. niyrrh. sesqui. turmeric. vetiver.: Textbook of Pharmacognosy; W. ginger. carrot. hesperidin & Flavonoids from orange peel powder. sandalwood. podophyllum 7. N. Tyler V. Bristol. The Indian Pharmacopoeia: The Controller of Publication; Delhi. Topic Quality assurance (discuss specimen documents) Raw material control. mixing and granulation. C.: Anatomy of Crude Drugs: Manipal Power Press. & Nayak S. Brain K. liquids. purity. facilities.: The Practical Evaluation of Phytopharmaceuticals: Wright. D. responsibilities & training..: Pharmacognosy of Powdered drugs: Manipal Power Press. 11. Qualification Process Validation – steps & documentation (Brief). sampling & sampling plans. No. inventory control. layout of manufacturing facilities. 1. 14. N. packaging and labeling control. 3. G.; Practical Pharmacognosy; New Vrinda Publishing House. C. selection. production planning. Vasudevan T. liquids and semisolids. Jalgaon.: Practical Pharmacognosy: Vallabh Prakashan. 12. 8 6. Maintenance & Retrieval of Documents. Pune. actives and inactive. standards of identity. equipment selection. Materials management. 9. A. Validation of sterilization process and equipment – microbial death kinetic terms. Pilot plant scale up techniques – group’s responsibilities. elements of cost & cost controls. 4 . 4. Khandelwal K. vendor audit. batch manufacturing records. warehousing. handling of components and containers. Personnel – qualifications. cGMP. Validation – Definition. 15. Charts. Laddha K. finished product control. Iyenger M. environmental aspects. Scientica. 13. R. mixer. in process control. R. materials of construction. Manipal. steps for validating steam sterilization method Production management Pharma industry – current scenario Site selection and development – factors to be considered in designing a facility. Examples of Typical layout schemes for Tablets. F Value applications. Q.: Practical Pharmacognosy Techniques and Experiments; Nirali Prakashan. S. SOPs. Kokate C. granulator. & Turner T. 10. 84 | P a g e Hours 8 2. S. Documentation – need/ importance. K. Wagner. A. sanitization. Iyenger M. Examples – Raw Materials. maintenance and service aspects. environmental and microbiological control. Q. 3 5 5 5. capsule. Bladi & Zgainski: Plant Drug Analysis; Springer Verlag.8. Manipal. quality and potency. Types. standard operating procedures. sales forecasting. sterile formulations manufacturing areas. example of scaling up of manufacturing of tablets. Factory Layout considerations/ steps. PHARMACEUTICS VII 3 hrs/ week Note: References to latest amendments of schedule M and Schedule U of Drugs and Cosmetics Act 1940 to be made wherever it is appropriate. evaluation. L.. 6 5. in vivo. st The science and practice of Pharmacy. intraocular solutions. Nash Robert A. ed. 1990. A. Liberman. by Leon Lachman. Minidisc. 3 ed. Vol.. pilocarpine ocular insert. Kanig. I and II. 2. factors enhancing intestinal drug uptake. techniques pan coating. lymphatics in intestine. equipments. Graham. 1987. Mucoadhesive drug delivery systems Mucoadhesion and theories. particulates. L.. Verghese Publishing house. different types of TDDS and release control mechanisms. Topic 3 hrs/ week Hours 2 Oral Controlled Drug Delivery Systems a) Multiparticulate drug delivery systems (Pellets) need and significance of pelletization. polymers. Cole. prodrug and delivery systems examples. by Kenneth A. modes of percutaneous penetration. B.Reference Books: 1. 21 ed. New York.. 1. Volume 57. The theory and practice of industrial pharmacy. approaches.. parental drug administration for lymphatic transport 85 | P a g e 1 2 2. oral osmotic pumps. Ocular drug delivery systems Limitations of conventional systems. II. 3. 6 4. 5. factors influencing mucoadhesion. classification. production. Pharmaceutical dosage forms; parenteral medications. bioadhesive polymers and systems. III. Ltd. rd Liberman. ed. nd Pharmaceutical Process Validation. 1986. 2005. enhancers. Berry Ira R. 1 2 . Design of GRDDS technologies low density (Floating systems). J. Introduction to targeting. 4. Evaluation of GRDDS. Marcel Dekker Inc. NOVEL DRUG DELIVERY SYSTEMS S. Marcel Dekker INC. Avis. evaluation b) Osmotic Systems Basic principles. No. Passive and active targeting a) Targeting to lymphatic systems Anatomy of lymphatic system. “Pharmaceutical Production Facilities: Design and Application”. Mucoadhesive systems. Remington.. Transdermal drug delivery systems (TDDS) Skin and skin permeation.. SCDI. 1992. evaluation of PSA and TDDS – in vitro. high density systems. H. ophthalmic insectsnonerodible and erodible inserts. A. ocular iontophoresis. Swelling and expanding systems. applications & evaluation c) Gastroretentive drug delivery systems (GRDDS) Regional variability in intestinal absorption and concept of absorption window. Leon Lachman and H. extrusion and spheronization. NODS. I. in vitro in vivo methods to study mucoadhesion. 2 Edition. Vol. 4 3. components of TDDS. Publications Pvt. Lacrisert. J. Swabrick. Rhodes.. P.. 3 ed. Publications Pvt. e) Colonic targeting Physiology of colon.19. “Encyclopedia of Pharmaceutical Technology.8. I and II. approaches prodrug. 1 Edition. “Targeted and Controlled Drug Delivery Novel Carrier Systems”. 1996. Marcel Dekker INC. 14. CBS publishers and distributors. biodistribution. Controlled drug delivery. Kanig. c) Drug targeting to brain The blood brain barrier. New York. Reference Books: 1. Vyas and R.. 2 1 2 3 9. 2 Edition. Remington. characterization. Marcel Dekker Inc. The theory and practice of industrial pharmacy. Ltd. evaluation. CBS Publishers and Distributors. K. Khar. transport through blood brain barrier. factors affecting drug permeation through BBB. Volume 166. 4. size reduction. Volume 58. B. K. 1996. New York. 7. Khar. Mathiowitz Edith.L.. Ophthalmic Drug Delivery Systems..15. Volume 74. ed. Khar R. 6. Ashim K. 2002. 2004. Revised and Expanded ed. Vallabh Publishers.6. Volume 98.13. Volumes 1. Boylan. A. Novel Approaches. Verghese Publishing house. by N. by N.. Targetted and controlled drug delivery. Marcel Dekker Inc. Banker and Christopher T. 12. 4 ed. applications. 1 Edition. 1997. Chickening III. L. Thassu Deepak. Advances in controlled and novel drug delivery. 86 | P a g e . Vol. New York. characterization. Jain. 8.” Marcel Dekker Inc. Marcel Dekker Inc. and Development. Vitas and R. by Leon Lachman. 15. 3. Marcel Dekker Inc. ed. evaluation and applications. CBS Publishers and Distributors.. 13. th Modern Pharmaceutics.17.16.20. P. 2002. by Gilbert S. 2007. azo polymers.14. CBS publishers and distributors. st Controlled and Novel Drug Delivery. CBS publishers and distributors. H. 2001. 1995. P. K. Jain N. difficulties in colonic targeting.. concepts and advances. 5.. 2002. time release systems. strategies for brain drug delivery d) Nanoparticles Preparation techniques. Novel carrier systems. Dellers Michael. Marcel Dekker INC. Benita Simon. osmotic systems. nd “Microencapsulation Methods and Industrial Applications”. S. Bioadhesive Drug Delivery Systems Fundamentals.10. New York.. New Delhi... 21 ed. Lehr ClausMichael.9. S. Controlled and Novel drug delivery. polysaccharides. Oral Mucosal Drug Delivery. Vyas S. stability. K..18. Donald E. st The science and practice of pharmacy. pH sensitive polymers. 11.12. 2002. st K. methods of preparation. Nanoarticulate Drug Delivery Systems.b) Liposomes Structural components and classification. 2. Jain. 2005. New York. Pathak Yashwant. New Delhi. K. 1987. 2006. Rathbone Michael J. New York. rd Liberman. 10. 1993. ed. Mitra. Narcotic Drugs and Psychotropic Substances Act · Definitions · Narcotics Commissioner and other officers · Illicit Traffic and measures to prevent illicit traffic of opium. Drugs and Magic Remedies (Objectionable Advertisements) Act 1954. · Various offences and corresponding Penalties · Broad content of various Schedules of the Drugs and Cosmetic Act and Rules. Controlling Authorities and Customs Collectors · Provisions Governing Import. Manufacture and Sale of Drugs. central food laboratory. Savings. Manufacture and Sale of Homeopathic Drugs. · Offences and corresponding penalties. Licensing Authorities. Topic 3 hrs/ week Hours 1 5 Historical perspective including details of Chopra Committee and Hathi Committee An objective study of the following Acts mearporating the latest amendments Pharmacy Act 1948 · Definition · PCI and State Councils. restricted and unrestricted preparations · Manufacturing in bond and outside bond Prevention of Food Adulteration Act 1954 · Definitions · Central board of food standards. 7. 14 4. 2. · Definitions. Composition and Function · Preparation of Registers and qualifications for entry into registers · Educational Regulation and Approval of Courses and Institutions · Offences and Penalties Drugs and Cosmetic Act 1945 · Definitions · Advisor bodies DLAB and DCC Composition and function · Drug Control Laboratories and Government Analysts · Drug inspectors. · Labeling and Packaging of Drugs · Provisions applicable to manufacture and Sale of Ayurvedic Drugs · Provisions Governing Import.FORENSIC PHARMACY AND JURISPRUDENCE S. Drug Price Control Order 1995 and new Drug Policy Medicinal ad Toilet Preparations (Excise Duties) Act. · Definitions. 2 . No. Prohibited Advertisement. 5. 2 2 6. compositions and functions · Public analysis and food inspectors Indian Patents Act 1975 87 | P a g e 3. 2 9. 1. 2 2 8. 2. Vallabhprakashan. K. D & C Acts. th “Forensic Pharmacy”. 4. search. W. scope and objectives) Concept of therapeutic drug monitoring and patient compliance Role of Pharmacist as a patient councilor Rational use of drugs Drug drug interactions – possible mechanisms and examples Drug interaction with food. 1 Reference Books: 1. 1999. No. Nirali Prakashan. jurisdiction and power · Provisions governing entry. 2005. 4 edition. bailable and non bailable offences.10. CLINICAL PHARMACY AND DRUG INTERACTION S. Sumit Publishers 2006. 3. 3. 11. 5 Reference Books: 1. alcohol. Mumbai. Career Publications. community pharmacy and hospital pharmacy (definition. Deshpande and Nilesh Gandhi. tobacco Adverse drug reactions – Types and examples Detection and Prevention of ADR Drugs used in geriatrics. Tipnis. 1940 and Rules. Kuchekar and Kadtare and Itkar. Bajaj. pediatrics and pregnancy Irrational drug combination Dose adjustment in renal and hepatic dysfunction General Introduction to drug discovery and development PreClinical Stages Clinical development – phases of clinical trials Commercial Aspects 5. Bombay Shops and Establishments Act · Definitions and Provisions Factories Act 1954 · Definitions and Provisions Indian Penal Code and Code of Criminal Procedures · Provisions pertaining to different Courts. Cognizable and noncognizable offences Insecticides Act · Definitions · Procedure for licensing and registration of Insecticides · Savings 1 1 1 13. S. Govt. Jain. th “Textbook of Forensic Pharmacy” N. 88 | P a g e . 5 edition. Dr. 2. of India Publication of above Acts and Rules. st Clinical Pharmacy Dr. 1945. 2003. 4. arrest. 12. Topic 3 hrs/ week Hours 6 6 3 16 Concept of clinical pharmacy. 1. 1 Edition. Dissolution testing – Marketed formulations of conventional tablets – soluble drug & poorly soluble drug (selection of medium) Ophthalmic DDS Mucoadhesive gel and evaluation. glycosides (liquorice). PHARMACOGNOSY LABORATORY III S. 2006. 2. volatile oils (clove. asparagus. 7. 6. Churchill Livingstone. myrrh. dill. Extraction and detection of phytoconstituents of following classes (Any two examples of each class) Flavonoids. kalmegh. cinnamon. evaluation of the products. SR suppositories PEG base and Hydrogel base evaluation of in vitro release. 9 Edition. J. and aloes). 3. quassia. Churchill Livingstone. Microencapsulation by coacervation phase separation technique of a liquid (volatile oil) & a solid (Charcoal/ Paracetamol). 1. 2 1 1 14 89 | P a g e . 4. Topic 4 hrs/ week Hours 8 2 Macroscopy microscopy of liquorice. Morphological identification of drugs covered in theory (volatile oils and glycosides) any 20 samples Total 3. benzoin. oral tablets use of hydrophobic and hydrophilic matrix materials (monolithic and reservoir) preparation and in vitro release evaluation. anise. Orientlongman. cardamom. picrorrhiza. brown. No. dill) Qualitative analysis of unorganized drugs as covered drugs as covered in theory (asafetida. Parthisarathi. Clive Edwards. rd Clinical Pharmacy and Therapeutics Roger Walker. 4 hrs/ week S. 3. Microscopic evaluation of Ayurvedic churna formulation & analysis of total tannins from Triphala churna. 2004.2. Nahata. Benett. Milap C. N. 2. R. PHARMACEUTICS LABORATORY V 1. 3 Edition. th Clinical Pharmacology P. guggul. Karin Nyfort Hansen. Text Book of Clinical Pharmacy Practice G. 4. 2003. 5. coriander. fennel. 4. M. fennel. Accelerated stability testing of any suitable drug/ formulation Demonstration of sugar and film coating of tablets. 5. clove. PHARMACEUTICAL ANALYSIS LABORATORY III 1. Identification of sample by TLC. 10. Assay of phenylephrine hydrochloride ophthalmic solution by difference spectroscopy. 2. Assay of trimethoprim in cotrimoxazole tablets as per I. Demonstration experiments: 1. 2. P. 5. Assay of sample by HPLC/ HPTLC/ GC. Determination of K+ from KCI by flame photometry. 3. Rifampicin capsules as per I. Assay of nifedipine and atenolol tablets by UV. 11. 8. 4. Assay of caffeine and sodium benzoate injection by simultaneous equation method and absorbance ration method. 4. Study of quenching effects of iodide ions on fluorescence of quinine sulphate. Assay of paracetamol tablets. 90 | P a g e . 7. Selection of mobile phase for TLC. 3. albendazole tablets. 6. Assay of quinine sulphate by fluorimetry. Determination of HCl and phosphoric acid in a given mixture potentiometrically. 4 hrs/ week Determination of pka 1 and pka 2 of phosphoric acid. Identification of amino acids by paper chromatography. P. 5. Qualitative analysis by I. 9. R. propanolol tablets. Determination of streptomycin base colorimetrically from Injection.