BMS 817378Sunday, January 16, 2011,1:28:13 PM Catalog No.:S2183 Product: BMS 817378 Category: By Product Pathways » Angiogenesis/Tyrosine Kinase » VEGFR-PDGFR » BMS 817378 Biological Activity:BMS817378 is a preclinical small molecule MET/VEGFR-2 inhibitor. It is the prodrug of BMS-794833. AG14361 Sunday, January 16, 2011,1:25:06 PM Catalog No.:S2178 Product:AG14361 Category:By Product Pathways » PARP» PARP » AG14361 Biological Activity:AG14361 is a potent poly(ADP-ribose) polymerase (PARP-1) inhibitor with a GI50 of 10.9 µM. LY2784544 Sunday, January 16, 2011,1:18:57 PM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S2179 Product:LY2784544 Category:By Product Pathways » Jak/Stat Pathway » JAK» LY2784544 Biological Activity:LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM. MLN9708 Sunday, January 16, 2011,1:18:56 PM Catalog No.:S2181 Product:MLN9708 Category:By Product Pathways » Proteases/HSP90/HSP70 » Proteasome» MLN9708 Biological Activity:MLN9708 is an orally bioavailable second generation proteasome inhibitor with potential antineoplastic activity. SB 743921 Sunday, January 16, 2011,1:12:12 PM Catalog No.:S2182 Product:SB 743921 Category:By Product Pathways» Aurora/Ksp »Ksp » SB 743921 Biological Activity:SB743921 is a second generation, highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Domperidone(Motilium) Sunday, January 16, 2011,1:08:03 PM Catalog No.:S2461 Product:Domperidone(Motilium) Category:By Research Area» Neurological Disease » Domperidone(Motilium) Biological Activity:Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. Dehydroepiandrosterone Sunday, January 16, 2011,1:03:24 PM Catalog No.:S2460 Product:Dehydroepiandrosterone Category:By Product Pathways » Others » Androgen Receptor » Dehydroepiandrosterone(DHEA) Biological Activity:Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone. Clozapine(Clozaril) Sunday, January 16, 2011,12:57:13 PM Catalog No.:S2459 Product:Clozapine(Clozaril) Category:By Research Area»Neurological Disease » Clozapine(Clozaril) Biological Activity:Clozapine(Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5HT-stimulated phosphoinositide hydrolysis. Chlorpromazine hydrochloride Sunday, January 16, 2011,12:53:49 PM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S2456 Product:Chlorpromazine hydrochloride Category:By Research Area » Neurological Disease » Chlorpromazine hydrochloride(Sonazine) Biological Activity:Chlorpromazine hydrochloride(Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents. Sotalol hydrochloride Sunday, January 16, 2011,12:48:43 PM Catalog No.:S2509 Product:Sotalol hydrochloride Category:By Product Pathways » Ion channel »Beta-1 receptor » Sotalol hydrochloride(Betapace) Biological Activity:Sotalol(Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Scopolamine hydrobromide Sunday, January 16, 2011,12:40:22 PM Catalog No.:S2508 Product:Scopolamine hydrobromide Category:By Research Area » Neurological Disease » Scopolamine hydrobromide Biological Activity:Scopolamine is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. Salbutamol sulfate Sunday, January 16, 2011,12:34:04 PM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S2507 Product:Salbutamol sulfate Category:By Research Area » Neurological Disease » Salbutamol sulfate(Albuterol) Biological Activity:Salbutamol(Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. Roxithromycin(Roxl-150) Sunday, January 16, 2011,12:28:42 PM Catalog No.:S2506 Product:Roxithromycin(Roxl-150) Category::By Research Area » Infection » Roxithromycin(Roxl-150) Biological Activity:Roxithromycin(Roxl-150) is a semi-synthetic macrolide antibiotic. Rosiglitazone maleate Sunday, January 16, 2011,12:25:32 PM Catalog No.:S2505 Product:Rosiglitazone maleate Category:By Research Area» Immunology » Rosiglitazone maleate Biological Activity:Rosiglitazone maleate is an anti-diabetic drug in the thiazolidinedione class of drugs. Racecadotril(Acetorphan) Sunday, January 16, 2011,12:22:05 PM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S2503 Product:Racecadotril(Acetorphan) Category:By Research Area » Metabolic Disease» Racecadotril(Acetorphan) Biological Activity:Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 µM. Hexestrol(Bibenzyl) Sunday, January 16, 2011,12:18:32 PM Catalog No.:S2473 Product:Hexestrol(Bibenzyl) Category:By Product Pathways »Hormone» Estrogen receptor »Hexestrol(Bibenzyl) Biological Activity:Hexestrol(Bibenzyl) is a novel type of 17β-hydroxysteroid dehydrogenase, AKR1C1and AKR1C2 potent inhibitor with IC50 of 0.8, 9.5, 2.8 µM, respectively and exhibits strong affinity for estrogen receptors. Xylazine(Rompun) Sunday, January 16, 2011,12:12:52 PM Catalog No.:S2516 Product:Xylazine(Rompun) Category:By Research Area» Neurological Disease » Xylazine(Rompun) Biological Activity:Xylazine(Rompun) is α2 class of adrenergic receptor agonist. As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Tenoxicam(Mobiflex) Sunday, January 16, 2011,12:09:00 PM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S2512 Product:Tenoxicam(Mobiflex) Category:By Research Area »Inflammation » Tenoxicam(Mobiflex) Biological Activity:Tenoxicam(Mobiflex) is a good HO. radicals scavenger with an IC50 of 56.7 µM. The high susceptibility of the drug to HO. Sulfadoxine(Sulphadoxine) Sunday, January 16, 2011,12:05:53 PM Catalog No.:S2511 Product:Sulfadoxine(Sulphadoxine) Category:By Research Area »Infection » Sulfadoxine(Sulphadoxine) Biological Activity:Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 µg/ml for P. vivax. Spectinomycin hydrochloride Sunday, January 16, 2011,12:02:06 PM Catalog No.:S2510 Product:Spectinomycin hydrochloride Categoey:By Research Area » Infection »Spectinomycin hydrochloride Biological Activity:Spectinomycin hydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis. Emtricitabine Sunday, January 16, 2011,11:56:20 AM Catalog No.:S2465 http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Product:Emtricitabine(Emtriva) Category:By Product Pathways » Others »NART » Emtricitabine(Emtriva) Biological Activity:Emtricitabine(Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM for HIV-1. Manidipine dihydrochloride Sunday, January 16, 2011,11:51:56 AM Catalog No.:S2482 Product: Manidipine dihydrochloride Categoey:By Research Area »Cardiovascular Disease » Manidipine dihydrochloride(CV-4093) Biological Activity:Manidipine(CV-4093) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. Quinine hydrochloride dihydrace Sunday, January 16, 2011,11:17:07 AM Catalog No.:S2502 Product:Quinine hydrochloride dihydrace Categoey:By Research Area » Neurological Disease » Quinine hydrochloride dihydrate Biological Activity: Quinine hydrochloride dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. Lidocaine hydrochloride monohydrate Sunday, January 16, 2011,10:51:30 AM Catalog No.: S2478 http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Product:Lidocaine hydrochloride monohydrate Category:By Research Area » Neurological Disease» Lidocaine hydrochloride monohydrate(Lignocaine) Biological Activity: Lidocaine hydrochloride monohydrate(Lignocaine) is a common local anesthetic and antiarrhythmic drug. Vidarabine(Vira-A) Thursday, December 16, 2010,11:02:37 AM Catalog No.: S1784 Product: Vidarabine(Vira-A) Category: By Research Area »Infection » Vidarabine(Vira-A) Biological Activity: Vidarabine(Vira-A) is an antiviral drug which is active against herpes simplex and varicella zoster viruses. TWS119 Thursday, December 16, 2010,10:58:13 AM Catalog No.: S1590 Product: TWS119 Category: By Product Pathways »PI3K/Akt/mTOR » GSK-3 » TWS119 Biological Activity: TWS119 is a glycogen synthase kinase-3β inhibitor with an IC50 of 30 nM. At 400 nM. Ubenimex(Bestatin) Thursday, December 16, 2010,10:53:10 AM Catalog No.: S1591 Product: Ubenimex(Bestatin) Category:By Product Pathways » Proteases/HSP90/HSP70 » Aminopeptidase » Ubenimex(Bestatin) Biological Activity: Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS VCH-759 Thursday, December 16, 2010,10:50:01 AM Catalog No.: S1592 Product: VCH-759 Category:By Product Pathways »Others »HCV protease » VCH-759 Biological Activity: VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with submicromolar IC(50) values versus genotype 1a/1b replicons. KU-60019 Thursday, December 16, 2010,10:46:39 AM Catalog No.: S1570 Product: KU-60019 Category: By Product Pathways »Others » ATM » KU-60019 Biological Activity: KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. Candesartan(Atacand) Thursday, December 16, 2010,10:41:19 AM Catalog No.:S1578 Product: Candesartan(Atacand) Category: By Product Pathways» Others » ATR» Candesartan(Atacand) Biological Activity: Candesartan is an angiotensin II receptor antagonist with an IC50 of 15 µg/kg. Detomidine hydrochloride(Dormosedan) Thursday, December 16, 2010,10:36:34 AM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.: S1579 Product: Detomidine hydrochloride(Dormosedan) Category: By Research Area » Neurological Disease » Detomidine hydrochloride(Dormosedan) Biological Activity: Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist. Diclofensine(Ro 8-4650) Thursday, December 16, 2010,10:33:03 AM Catalog No.: S1580 Product: Diclofensine(Ro 8-4650) Category: By Research Area » Neurological Disease » Diclofensine(Ro 8-4650) Biological Activity: Diclofensine is a stimulant drug which acts as a triple reuptake inhibitor and a novel antidepressant H 89 dihydrochloride Thursday, December 16, 2010,10:27:00 AM Catalog No.:S1582 Product: H 89 dihydrochloride Category: By Research Area » Neurological Disease » H 89 dihydrochloride Biological Activity: H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b, respectively. Nepicastat(SYN117) Thursday, December 16, 2010,10:19:02 AM Catalog No.:S1583 http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Product:Nepicastat(SYN117) Category: By Research Area » Cardiovascular Disease » Nepicastat(SYN117) Biological Activity: Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. BS-181 hydrochloride Thursday, December 16, 2010,10:15:37 AM Catalog No.: S1572 Product: BS-181 hydrochloride Category: By Product Pathways » Cell Cycle/Checkpoint » CDK» BS-181 Biological Activity: BS-181 is a potent and selective CAK activity inhibitor with an IC50 of 21 nM. PD318088 Thursday, December 16, 2010,10:12:18 AM Catalog No.: S1568 Product: PD318088 Category: By Product Pathways » MAPK »MEK » PD318088 Biological Activity: PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. BMS-740808 Thursday, December 16, 2010,9:56:42 AM Catalog NO.: S1571 Product: BMS-740808 http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Category:By Product Pathways » Others » Factor Xa » BMS-740808 Biological Activity: BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable blood coagulation factor Xa inhibitor with a Ki of 30 pM. Ramipril(Altace) Thursday, December 16, 2010,9:52:22 AM Catalog No.: S1793 Product: Ramipril(Altace) Category: By Product Pathways » MAPK »Ras » Ramipril(Altace) Biological Activity: Ramipril(Altace) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. Ranolazine(Ranexa) Thursday, December 16, 2010,9:48:09 AM Catalog No.: S1799 Product: Ranolazine(Ranexa) Category: By Research Area » Cardiovascular Disease » Ranolazine(Ranexa) Biological Activity: Ranolazine(Ranexa) is an antianginal medication. Disulfiram(Antabuse) Thursday, December 16, 2010,9:44:40 AM Catalog No.: S1680 Product: Disulfiram(Antabuse) Category: By Research Area » Neurological Disease » Disulfiram(Antabuse) Biological Activity: Disulfiram(Antabuse) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Monobenzone(Benoquin) Thursday, December 16, 2010,9:39:16 AM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.:S1652 Product: Monobenzone(Benoquin) Category: By Research Area » Metabolic Disease » Monobenzone(Benoquin) Biological Activity: Monobenzone(Benoquin) is a compound used as a topical drug for medical depigmentation. VX-809 Thursday, December 16, 2010,9:36:06 AM Catalog No.:S1565 Product: VX-809 Category: By Research Area » Immunology »VX-809 Biological Activity: VX-809 is the second investigational oral drug candidate for the treatment of cystic fibrosis (CF). PHT-427 Thursday, December 16, 2010,9:29:21 AM Catalog No.: S1556 Product: PHT-427 Category: By Product Pathways » PI3K/Akt/mTOR » Akt » PHT-427 Biological Activity: HT-427 is a Novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. AT7867 Thursday, December 16, 2010,9:19:43 AM http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM] Selleck Chemicals RSS Catalog No.: S1558 Product: AT7867 Category: By Product Pathways »PI3K/Akt/mTOR » Akt » AT7867 Biological Activity: AT7867 is a potent and oral AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM. http://www.selleckchem.com/rss.xml[1/28/2011 12:47:32 PM]
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