Product Guide, Fifth Edition

PRODUCT GUIDE5th Edition Milestones of 1958 Debut of Square Pharmaceuticals as a Partnership Firm. 1964 Incorporated as a Private Limited Company 1974 Technical collaboration with Janssen Pharmaceutica, Belgium, a subsidiary of Johnson & Johnson Intl, USA 1985 Achieved marketleadership in the Pharmaceutical market of Bangladesh among all national and multinational companies. 1987 Pioneer in Pharmaceutical export from Bangladesh 1991 Converted into a Public Limited Company 1994 Initial Public Square Pharmaceuticals’ shares. 1995 Chemical Division starts production of pharmaceutical bulk products (API). 1997 Won the National Export Trophy for exporting pharmaceuticals. 2001 US FDA/UK MHRA standard new Pharmaceutical factory goes into operation built under the supervision of Bovis Lend Lease, UK. 2002 Square enlisted as UNICEF’s global supplier. 2005 New State-ofthe-Art Square Cephalosporins Ltd. goes into operation; built under the supervision of TELSTAR S.A. of Spain as per US FDA/ UK MHRA requirements. 2007 Square Pharmaceuticals Ltd., Dhaka Unit gets the UK MHRA approval. 2009 Starts manufacturing of insulin, hormone & steroid products maintaining quality standards of US FDA, MHRA in dedicated manufacturing facility complying with the cGMP of WHO. 2012 Square Pharmaceuticals Ltd., Dhaka Unit gets the TGA approval. Australian Government Department of Health and Ageing Therapeutic Goods Administration Another milestone of excellence in its global presence In 2012 Square Pharmaceuticals Ltd. (Dhaka Unit) and Square Cephalosporins Ltd. got the TGA approval. Australian Government Department of Health and Ageing Therapeutic Goods Administration Achieving TGA approval attributes: 1. Pride of receiving one of the toughest regulatory certificates 2. Enhance the opportunity to market our products as a global player in the pharma market of Australia and other countries that accept the TGA 3. Recognition of world class quality products TGA ensures certification not only in manufacturing quality, but also in quality control, laboratory procedures, pharmaceutical good manufacturing practices, and standard operating procedures. This compilation includes active ingredient.Preface It is our immense pleasure to present the 5th edition of “Product Guide” to your hand. It is a handy book that contains the abridged prescribing information of SQUARE Pharmaceuticals’ products and also the products of SQUARE Herbal & Nutraceuticals Ltd. We believe that with the support of our valued doctors we would be able to keep on our endeavor to bring continual improvement. pediatric use and preparation. contraindication & precaution. this new edition is enriched with the following features: • Generic name wise index • Brand name wise index We hope that this new edition will be helpful in the daily practice of the doctors while treating patients. . In addition. side effects. Product guide is one of the special publications to update the doctors about SQUARE’s products in the most convenient way. indication. use in pregnancy & lactation. Sincerely Product Management Department SQUARE Pharmaceuticals Ltd. dosage & administration. Table of content by Brand name Product Ace Ace Plus Acetram Adiva Adryl Afun Afun VT Alacot Eye Drops Alarid Alarid Eye Drops Alatrol Almex Ambrox Amlosart Amodis Amodis 500 IV Anadol Anclog Anclog Plus Anespine Angilock Angilock Plus Angivent MR Anleptic Anoxa Anril Anril Spray Ansulin Antazol Antazol Plus Antista Page no. 1 1 2 2 3 4 4 4 5 5 6 6 7 7 8 10 11 11 12 12 13 14 14 15 16 17 17 18 18 19 19 . 19 20 20 21 22 23 23 23 24 25 25 25 26 26 27 27 28 29 29 30 31 32 32 33 33 34 34 35 36 36 37 .Table of content by Brand name Product Antiva Anzitor Apsol Aviflu Avudin B-50 Forte Bactrocin Barif Beclomin HFA Inhaler Becospray Benzapen Beovit Betameson-N Bicozin Bicozin-I Bisocor Bisocor Plus Brofex Bromolac Bufocort Burna Butefin Cadnyl Calbo 500 Calbo-C Calbo-D Calbo Forte Calbo Jr Calboplex Calcitrol Camlodin Page no. Table of content by Brand name Product Camlodin Plus Camlopril Camlotor Camoval Candex Capsi Carbizol Cardipro Cardipro Plus Carva Cavir Ceevit Ceevit Forte Cef-3 Cefotil Ceftron Cerevas Cilosta Cinaron Cinaron Plus Ciprocin Ciprocin Eye/Ear Drops Ciprocin 200 IV Climycin Clinface Gel Clobam Clofenac Clotinex Colicon Comet Comprid Page no. 38 38 39 40 40 40 41 42 42 42 43 44 45 45 45 46 47 47 48 48 49 49 50 51 52 53 53 54 56 56 57 . 58 58 58 59 60 60 61 61 61 62 63 63 64 65 66 66 67 67 68 69 69 70 71 72 73 74 75 75 75 76 76 .Table of content by Brand name Product Contifil Contilex Cotrim Defiron Delipid Depram Deprex De-rash Dermasol Dermasol-N Dermasol-S Dexonex Dexonex Eye/Ear Drops Dexonex-C Eye/Ear Drops Dibenol Diliner DR Diltizem SR Diprobet Doxacil Dormitol Durol Dyvon Dyvon Plus Eczena Efigrel Elzer Emcil Entacyd Entacyd Plus Epinal Epitra Page no. Table of content by Brand name Product Equra Erian Ermox Eromycin Eromycin Lotion Esloric Esmo Esmo LA Espa Evit Eyevi Ezex Facticin Famotack Femastin Fe-plus Fexo Fexo Plus Filfresh Filwel Gold Filwel Kids Filwel Silver Flacol Flexi Flexilax Flonaspray Flugal Flurizin Fona Fona Plus Gel Force Page no. 77 77 78 78 79 79 80 80 81 81 82 82 82 83 83 84 84 85 86 86 87 87 88 88 88 89 89 90 91 91 92 . Table of content by Brand name Product Frabex Fungidal Fungidal BT Fungidal-HC Fusid Fusid Plus Gabastar Gelora Genacyn Eye/Ear Drops Genacyn Injection Genacyn Ointment Genisia Germisol Hand Rub Geston Glyros Gynepro Halobet Hemorif Hepavir Hivarif Imotil Inflagic Iprex Inhaler Iprex Respirator Solution Iprex Nebuliser Solution Isovent Itra Ivanor Iventi Eye Drops Kalinac Ketoral Page no. 92 93 93 94 94 95 96 96 97 97 98 98 99 100 100 101 101 103 103 103 104 104 106 106 107 107 108 109 110 110 111 . 111 112 113 114 114 114 115 115 116 116 116 117 117 118 118 119 119 120 120 121 122 122 123 124 126 126 127 127 128 128 129 .Table of content by Brand name Product Kitex K-One MM Kop Laciten Lanso Laxyl Lebac Lerozol Levocar Levostar Levostar Inhaler Lipired Livwel Locular Eye Drops Loracef Loratin Loratin Fast Loratin Plus Lubtear Eye Drops Lumertam Maganta Plus Malacide Maxcef Maxpime Maxrin Melcam Melixol Menoral Merison Metaspray Nasal Spray Methicol Page no. Table of content by Brand name Product Mevin Mexlo 400 Mexlo Eye Drops Miclofenac Migranil Mirakof Montene Motifast Motigut Moxacil Moxaclav Mucospel Multivit Plus Mymix Myonil Nacromin Nasal Drops Nalid Naurif Nebanol Nebanol Plus Nectar Nelvir Neotack Nepranol Neuro-B Neurolep Neurolin Nexum Nidipine SR Nidipro Nilac Page no. 130 130 130 131 131 132 132 133 133 134 134 135 136 136 136 137 137 138 138 139 139 139 140 140 141 142 142 143 145 145 146 . Table of content by Brand name Product Nimocal Nixalo Nocon Nomi Norpill 1 Norvent Inhaler Norvis Ocufen 0.D Oxapro Oxat 20 Oxifun Oxifyl CR Panodin SR Penrif Pentadol Penvik Peridol Perkinil Perkirol Peuritar Pevitin Page no. 146 147 147 148 148 149 150 150 151 151 152 152 153 154 154 155 155 156 157 157 158 158 159 160 160 161 161 162 162 163 163 .09% Eye Drops Ofkof Ofran Olicod Olmecar Olmecar Plus Oni Orogel Osmolax Ostel Ostel . Table of content by Brand name Product Phylopen Piramed Prolert Promtil Pronor Proxivir Purotrol Pylotrip Rabeca Radirif Rectocare Remac Remus Renorma Repres Plus Repres SR Revira Rex Rezulin Rice ORS Ripril Ripril Plus Risedon 150 Robic Rosuva Rutix Saga Salmate HFA Inhaler Sanit Scabex Seclo Page no. 164 164 166 166 167 167 169 169 169 171 171 172 172 173 173 174 174 175 176 177 177 178 178 179 180 180 180 181 181 182 182 . 184 185 186 186 187 188 188 189 190 190 190 191 192 192 193 193 194 194 195 195 196 196 197 197 198 198 199 200 200 201 201 .Table of content by Brand name Product Secnid Secrin Sedil Sedno Sensimet Servin Siglimet Siglita Simacor Snizex Solo Sonap Specbac SQ-Mycetin Square Zinc Stronel Sulprex HFA Inhaler Sulprex Nebuliser Solution Sultolin Sultolin Nebuliser Solution Sultolin Respirator Solution Tazid Tebast Tesod Tetrax Thyrin Ticamet Cozycap Ticamet Inhaler Ticas Timotor Tivizid Page no. 202 202 203 204 204 205 206 206 208 209 210 211 211 212 212 213 214 214 215 216 216 217 218 218 218 219 220 221 221 222 222 .Table of content by Brand name Product Togent Topicort Torax Tory Tos Tosirin Trevox Trevox 500 IV Trispray Trupan Tryptin Tusca Ucol 2 Uriten Valoate Vanprox Vasopril Versia Vertina Plus Viodin Virux Xcid Xenole Xfin Xflam Xripa Xten Zesup Zif Zif-CI Zif Forte Page no. 223 223 224 225 225 226 .Table of content by Brand name Product Zifolet Ziliron Ziliron-B Zimax Zimax Eye Drops Zox Natural Products Adovas AmCivit Arubin Colmint Enerton Eprim Eredex Eyebil Giloba Gintex Inacea Ispergul Jort Kamomil Livolite Monera Navit Pepnor Probio Silybin 228 228 228 229 229 230 230 230 231 231 232 232 233 233 233 234 234 235 235 236 Page no. back pain. myalgia. 120 mg/5 ml Syrup. Drug Interaction: It increases the Effect of chloramphenicol and coumarin anticoagulant. Risk of hepatotoxicity of paracetamol may be increased in . 3 months to below 1 year : 1/2 to 1 teaspoonful 3 to 4 times daily. Adults and children over 12 years : 0.Pain of colic.5 ml (40 mg) 4 to 11 months: 1. hips.1 mg. toothache. muscle ache. Rheumatism and osteoarthritic pain & stiffness of joints in fingers. 15 ml and 30 ml Paediatric Drops (80 mg/ ml). Dosage & Administration: Adults : 1-2 tablets every 4-6 hours. earache. bodyache. XR Tablet: 2 tablet every 6 to 8 hourly upto a maximum of 6 tablets daily. Indication: Fever. Children (6-12 years) 1/2 to 1 tablet 3 to 4 times daily.5 . 4 times daily. neutropenia & gastrointestinal disturbances etc. inflammatory pain. knees.0 ml (80 mg). elbows. headache. Side Effect: Side Effects are significantly mild. 60. and other allergic reactions occur Ace® Plus Active Ingredient: Caffeine. Not recommended for children below 12 years. Syrup and Suspension: Children Under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily. Paracetamol & A Indication: Fever. backache. and post-vaccination pain and fever of children. feet.5 ml (120 mg) Dose can be repeated. 4 times daily. 125. though haematological reactions have been reported. 1-5 years: 1-2 teaspoonful 3 to 4 times daily. migraine. 250 and 500 mg Suppository. Dosage & Administration: Tablet: Adult 1-2 tablets every 4 to 6 hours up to a maximum of 4 g (8 tablets) daily. Caffeine or any other components of it.Product Guide 1 occasionally. Contraindication & Precaution: Hypersensitivity to Paracetamol. 4 times daily. Children below 5 years : 125-250 mg. medical advice should be sought before using this product. Contraindication & Precaution: Known sensitivity to paracetamol. Maximum dose: 8 tablets daily. headache. Uses in Pregnancy & Lactation: Paracetamol is safe in all stages of pregnancy and lactation.neuralgia and sprains. every 4 hours. Children 3 months 1 year : 60-120 mg 4 times daily. Preparation: 500 mg Tablet. 6-12 years : 2-4 teaspoonful 3 to 4 times daily. Children 6-12 years : 250-500 mg. Side Effect: This combination may cause skin rashes. dysmenorrhoea. chronic pain of cancer. High dose administration may cause hepatotoxicity. XR Tablet. 120 mg/5 ml Suspension. Adults 4-8 teaspoonful 3 to 4 times daily. Paediatric Drop: Children upto 3 months: 0. Uses in Pregnancy & Lactation: Although there is epidemiological evidence of the safety of Paracetamol in pregnancy & lactation. toothache & menstrual pain. skin rashes. Pancreatitis. ankles and top & bottom of the spine. 1 to 2 years: 1. Suppository: Suppository should be administered rectaly. Ace® Active Ingredient: Paracetamol. wrists. insomnia. Indication: In combination with other antiretroviral agents is indicated for the treatment of HIV infection. once daily. anorexia. diarrhea. This combination preparation should be used with caution when taking medications such as tranquilizers. hypnotics or other opiate containing analgesics. flatulence. constipation. Use in Pregnancy & Lactation: Pregnancy Category C. anxiety.5 to <40 >40 Adiva: Dose (mg) 200 250 300 350 400 600 . somnolence pruritus.5 32.2 alcoholics or in patients taking other antiepilectic medications. Prolonged use of the drug without consulting a physician should be avoided.5 mg. the recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day. Dosage & Administration: Acetram tablet can be administered without regard to food. in patients taking other hepatotoxic medication. rash. increased sweating etc. should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. nausea. Product Guide Side Effect: The following adverse reactions may happen to this therapy: asthenia. its safety in infants and newborns has not been studied. Body weight (kg) 10 to <15 15 to <20 20 to <25 25 to <32. headache. once daily. Pediatric Patients : Weighing greater than 40 kg is 600 mg. abdominal pain. Preparation: Paracetamol 325 mg & Tramadol HCl 37. Acetram TM Active Ingredient: Paracetamol 325 mg & Tramadol HCl 37. euphoria. hot flushes. Preparation: Paracetamol 500 mg & Caffeine 65 mg. the recommended dose is 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.5 mg Tablet. in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs). In case of short-term (five days or less) management of acute pain. Dosage and Administration: Adults : 600 mg orally. nervousness. A Indication: Acetram tablet is indicated for the management of moderate to moderately severe pain in adults and also indicated for the short-term (five days or less) management of acute pain. dry mouth. Adiva® Active Ingredient: Efavirenz. vomiting. confusion. dyspepsia. Precaution: Should be given cautiously in the following cases: In patients with hepatic or renal failure. fatigue. Contraindication & Precaution: This is contraindicated in any situation where opioids are contraindicated. For the management of pain. dizziness. tremor. Product Guide Contraindication and Precaution: Contraindicated in patients with clinically significant hypersensitivity to any of its components.. Women of childbearing potential should undergo pregnancy testing before initiation of Efavirenz. 5) miscellaneous including meniere’s diseases and parkinsonism. Midazolam. Voriconazole.e. Indication: For the treatment of following: 1) Seasonal. Preparation: 600 mg Tablet. Children (above 9. Side Effect: Side Effects include drowsiness. Not to exceed 75 mg in 24 hours. Children (6 to 12 years) : 12. Pregnancy should be avoided in women receiving Efavirenz. Use in lactating mother is not recommended. . motion sickness. 3 (2. Uses in Pregnancy & Lactation: Should be used in pregnancy only if clearly needed. In parkinsonism: Adults: 25 to 50 mg 3 to 4 times a day. etc). Children (above 9. (5 ml of syrup) 3 to 4 times a day. Children 1 to 6 years of age: 5 mg i. Efavirenz may cause fetal harm when administered during the first trimester. perennial & vasomotor rhinitis.5 to 25 ml of syrup) 3 to 4 times a day.25 mg every 4 hours. drivers. nausea and vomiting. anaphylaxis. alcohol. para-aminosalicylic acid (PAS).5 ml of syrup) 3 to 4 times a day. Triazolam. machine operators.. Children 6 to 12 years of age : 10 mg i. 6) cough & cold. Cisapride. angioneurotic edema.5 mg every 4 hours. A Adryl ® Active Ingredient: Diphenhydramine. dizziness.1 kg): 12. Drug Interaction: Antituberculous agent. Preparation: 10 mg/5 ml Syrup. other CNS depressants (hypnotics. tranquilizers.1 kg) : 12. Drug Interaction: Efavirenz should not be administered with Astemizole. 3) pruritus. emesis.g. 4) preanesthetic medication. In motion sickness: Adults : 25 to 50 mg 3 to 4 times a day. Not to exceed 150 mg in 24 hours. Dosage and Administration: Most allergic conditions are controlled with 25 to 50 mg i.5 to 25 mg 3 to 4 times a day (5mg/ kg/ 24 hours). Uses in Pregnancy & Lactation: Pregnancy category D. (12. Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. blurred vision. 2) urticaria. Contraindication and Precaution: Contraindicated for the premature or newborn infants.5 to 25 mg 3 to 4 times a day (5mg/ kg/ 24 hours).. MAO inhibitors. Sometimes it may use as a night time sleep aid and for the short-term management of insomnia. sedatives. Mothers should be instructed not to breast-feed if they are receiving Efavirenz.e. Ergot derivatives. dryness of mouth. In insomnia: Adults and children over 12 years of old : A dose of 20 to 50 mg is used as hypnotic in insomnia. Any patients in whom drowsiness is undesirable e. Patients with known hypersensitivity to Diphenhydramine or any components of the product. Children (2 to 6 years): 6. In cough & cold: Adults: 25 mg every 4 hrs.e. Super-infections with Clotrimazole-sensitive bacteria. Afun® Active Ingredient: Clotrimazole. Alacot® Eye Drops Active Ingredient: Olopatadine.g. Dosage and Administration: One drop in each affected eye two times per day at an interval of 6 to 8 hours. balanitis. For prevention of re-infection the partner should be treated locally with Clotrimazole cream at the same time. Olopatadine Hydrochloride ophthalmic solution should not be used to treat contact lens related irritation. paronychia. Use in Pregnancy: It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician. 2 Afun vaginal tablets are inserted as deeply as possible into the vagina. Dosage and Administration: Afun VT: 3 consecutive nights. Contraindication and Precaution: Hypersensitivity to Clotrimazole. A Side Effect: Local irritation or burning may occur in very few cases. Use in Pregnancy: It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician. Preparation: 100 mg & 500 mg Vaginal Tablet with an applicator. Side Effect: Local irritation or burning sensation. Indication: Indicated for the treatment of the signs and symptoms of allergic conjunctivitis.4 Product Guide back with the knees slightly bent. Contraindication and Precaution: Hypersensitivity to clotrimazole. skin diseases showing superinfections with these fungi e. Dosage and Administration: 2-3 times daily. Trichophyton. inter digital mycoses. Preparation: 10 mg/gm Cream. Candida vulvitis. Indication: Vaginitis due to Candida or Trichomonas. This is best achieved when lying on the one’s . Afun® VT Active Ingredient: Clotrimazole. Indication: Dermatomycoses due to Candida. Afun VT is colorless and do not strain the underwear. Afun VT 500: Single dose. pityriasis versicolor and erythrasma. Contraindication and Precaution: Olopatadine Hydrochloride ophthalmic solution is contraindicated in persons with a known hypersensitivity to Olopatadine Hydrochloride. Moulds and other fungi. It is recommended that the treatment should be timed as so to avoid the menstrual period. Patients who wear soft contact lenses should be instructed to wait at least ten minutes after instilling Olopatadine Hydrochloride ophthalmic solution before they insert their contact lenses. not more than twice per day. Although there is no evidence of any teratogenic effect. Contraindication & Precaution: Hypersensitivity to Ketotifen or any of the components. This applies specially to systemic corticosteroids and ACTH because of the possible existence of adrenocortical insufficiency in steroid dependent patient. watery. lid edema. Children above 3 years : 1 mg twice daily with food. dry mouth and slight dizziness may occur at the beginning of treatment but usually disappear spontaneously after a few days. recommendations for Ketotifen in pregnancy or when breast feeding can not be given. nausea. sinusitis. The following adverse experiences have been reported in less than 5% of patients: Asthenia. red & swollen eyes and eyelids) of allergic conjunctivitis including vernal kerato-conjunctivitis.1% Eye Drops. blepharitis. rhinitis. dry eye. pruritus. hypersensitivity. Prophylactic treatment of bronchial asthma.025% eye drops . keratitis. If necessary the dose may be increased to 2 mg twice daily in severe cases. 5 with oral antidiabetic agent and it has been suggested that this combination should therefore be avoided. It is important to continue the previous treatment for a minimum of two weeks after starting Ketotifen to avoid the possibility of exacerbation of asthma. Dosage and Administration: Adults : 1 mg twice daily with food. Indication: Symptomatic treatment of allergic conditions including rhinitis and conjunctivitis. and taste perversion. pharyngitis. blepharoconjunctivitis. 1 mg/ 5 ml Syrup. Side Effect: Headaches have been reported at an incidence of 7%. Indication: For the treatment of signs & symptoms (itchy. every 8-12 hours. and giant papillary conjunctivitis.Product Guide Use in Pregnancy and Lactation: Should be used in pregnant women only if the potential benefit to the mother justifies the potential risk to the fetus. Use in elderly : Same as adult dose or as advised by the physician. Preparation: 0. Caution should be exercised when Olopatadine Hydrochloride ophthalmic solution is administered to a nursing mother. Alarid 0. cold syndrome. vernal-keratitis. Side Effect: Drowsiness and in isolated cases. Dosage & Administration: Adults and children 3 years and older:1 drop in the affected eye(s) twice daily. burning or stinging.5 to 1 mg at night for the first few days or as directed by the physician. A Alarid® Active Ingredient: Ketotifen. blurred vision. hyperemia. foreign body sensation. Patients known to be easily sedated should begin treatment with 0. Contraindication and Precaution: A reversible fall in the platelet count has been observed in a few patients receiving Ketotifen concomitantly Alarid® Eye Drops Active Ingredient: Ketotifen. Preparation: 1 mg Tablet. conjunctivitis. Adults & children (over 2 years): Ascariasis. 2. Dosage & Administration:12 to 24 months: 200 mg as a single dose (Half of Almex 400 tablet or 5 ml Almex suspension). Strogyloidiasis or taeniasis . Caution should be exercised when prescribing to pregnant women. Concurrent use with alcohol or other CNS depressants should be avoided because additional reduction in alertness and additional impairment of CNS performance may occur. Use in Pregnancy and Lactation: Cetirizine should be used in pregnancy only if clearly needed.hydroxyzine. dry eyes. a dose of 1/2 tablet or 1 teaspoonful once daily is recommended. It is also used in allergen induced asthma. Use in lactating mother is not recommended. <1%: Blurring of vision upon drug instillation. trichuriasis & hookworm infestation . Preparation: 10 mg Tablet. Drug Interaction: No clinically significant drug interactions have been found.400 . Indication: Single or mixed intestinal infections caused by various helminths. Syrup: 2 teaspoonfuls once daily or 1 teaspoonful twice daily. punctate corneal epithelial erosion. Chronic Idiopathic Urticaria. Use in Pregnancy & Lactation: Systemic levels after ocular administration are much lower than after oral use. A Preparation: 0. Use in Children: Children under 3 years of age: Consult with a doctor. 5 mg/5 ml Syrup.<2 years : Syrup: 1/2 teaspoonful once daily. Alatrol® Active Ingredient: Cetirizine. Indication: Seasonal Allergic Rhinitis. Children 6 months .6 should not be instilled while the patient is wearing lenses. eye pain. Perennial Allergic Rhinitis. photophobia.025% Eye Drops. The Almex® Active Ingredient: Albendazole. In patients with decreased renal function (Creatinine clearance 11-31 ml/min). eyelid disorder.5 mg/ml Paediatric Drops. Side Effect: 1-2%: Burning/stinging. Product Guide dose in children 12-23 months of age can be increased to a maximum dose as 1/2 teaspoonful every 12 hours. The dose in children 12-23 months of age can be increased to a maximum dose as 1 ml. and Pruritus. subconjunctival haemorrhage. Paediatric Drops: 1 ml. Adults and Children 6 years and older : Tablet: 1 tablet daily. Contraindication & Precaution: Hypersensitivity or idiosyncrasy to cetirizine or to its parent compound . enterobiasis. patients on hemodialysis (Creatinine clearance less than 7 ml/min) and in hepatically impaired patients .400 mg (One Almex 400 tablet or 10 ml Almex suspension) single dose. Children 2-6 years : Syrup: 1 teaspoonful once daily or 1/2 teaspoonful twice daily. Dosage and Administration: Administered with or without food. every 12 hours. once daily. Caution should be exercised when driving a car or operating a heavy machinery. Ambrox 75 SR Capsule: Adults and children over 12 years old . laryngitis. 6 .5 ml. Indication: Productive cough. Chronic pneumonia 7 Dosage and Administration: Paediatric Drops: 0 .25 ml.Product Guide mg once daily for three consecutive days. Bronchiectasis. Safety during lactation has not been established yet. diarrhoea. bronchial asthma with thick expectoration. For cystic echinococcosis the 28-days course may be repeated after 14 days without treatment to a total of three treatment cycles. Rarely eruption. alone or with . pruritis & dry mouth.2. Use in Pregnancy and Lactation: It is advised not to use in pregnancy.g. Hydatid disease (Echinococcosis) 400 mg twice daily for 28 days. Preparation: 400 mg Tablet & 200 mg / 5 ml Suspension.1 capsule. Contraindication and Precaution: Known hypersensitivity to Ambroxol or Bromhexine. constipation. 75 mg SR Capsule.400 mg once daily for five days. Use in Pregnancy & Lactation: Should not be administered during pregnancy & in women thought to be pregnant.5 ml (1 teaspoonful). 2-3 times a day. A Ambrox® Active Ingredient: Ambroxol. Preparation: 6 mg/ml Paediatric Drops. 15 mg/5 ml Syrup. Should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders.5 ml (1/2 teaspoonful). 10 years old and adults . stomach overfill feeling may occur occasionally.0.2 years old -1. especially during the1st trimester. sinusitis and rhinitis associated with viscid mucus. Syrup : 2 -5 years old . vomiting. 2-3 times a day. 2 times a day. 3 times a day. 2 times a day.1 ml. Asthmatic bronchitis. Amlosart TM Active Ingredient: Olmesartan. Giardiasis . urticaria or angioneurotic edema has been reported. Pediatric Use: For children of 12 months & above. nausea. 400 mg twice daily for 28 days followed by 14 days without treatment may need to continue for months or years. For alveolar echinococcosis. Side Effect: Epigastric pain. once daily Side Effect: Epigastric pain. Pharyngitis. Patients with hepatic and renal insufficiency should take it with caution. Drug Interaction: Ambroxol should not be taken simultaneously with antitussives (e. 5 . Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis.10 ml (2 teaspoonful). 1 . dizziness. Codeine). 2 times a day. Contraindication & Precaution: Should only be used in the treatment of echinococcosis if there is constant medical supervision with regular monitoring of serum transaminase concentrations and of leucocyte and platelet counts.10 years old .12 months old .6 months old . headache. Amlodipine + Indication: Hypertension. Precaution: When pregnancy is detected.8 other antihypertensive agents. Indication: • All forms of amoebiasis (intestinal and extra-intestinal disease including liver abscess and that of symptomless cyst passers) • Trichomoniasis • Giardiasis • Bacterial vaginosis • Acute ulcerative gingivitis Anaerobic infections including • septicaemia. bacteraemia. Drug Interaction: No significant drug interactions have been observed when used individually or in combination. rhabdomyolysis. flushing.g. pelvic abscess. osteomyelitis. Patients with Congestive Heart Failure: Calcium channel blocker should be used with caution in patients with Impaired Renal Function / Hepatic Impairment/ congestive heart failure. Symptomatic hypotension may occur after initiation of therapy. Not Product Guide Amodis® Active Ingredient: Metronidazole. necrotising pneumonia. brain abscess. palpitation. peritonitis. Preparation: Amlodipine Olmesartan 20 mg Tablet. or severity of angina or acute MI on starting calcium channel blocker therapy or at the time of dosage increase. Use in Pregnancy & Lactation: recommended. pylori-the most important aetiological factor of peptic ulcer) A Use in Children: Safety and effectiveness have not been established. this combination drug should be discontinued as soon as possible. • Anaerobically-infected leg ulcers and pressure sores • Acute dental infections (e. pelvic cellulitis etc. when administering this combination. alopecia. pruritus. Maximum dose two tablets (10/40 mg) once daily. urticaria etc. Dosage & Administration: One tablet (5/20 mg) once daily. Contraindication & Precaution: Contraindication: Hypersensitivity to any of the component of this combination product. May be taken with or without food. Exercise caution. Side Effect: Edema. acute pericoronitis and acute apical infections) Surgical prophylaxis (prevention of • postoperative infections due to anaerobic bacteria. diarrhoea. puerperal sepsis. 5 mg + . dizziness. It can be used as initial therapy.particularly species of bacteroides and anaerobic streptococci Chronic symptomatic peptic ulcer • disease (as an agent of triple therapy to eradicate H. Patients may develop increased frequency. duration. particularly in patients with severe aortic stenosis. vomiting. t.d.d q.d.i. b.5 mg/kg mg every 8 t. 100 mg mg t.i.i.0 gm once 1. 400 t.Product Guide Dosage & administration: Indication & Duration Adults of dosage children over 7-10 years in days 10 years 7 200 mg t.i.i.i.0 gm daily daily once daily 600-800 mg 500 mg 200 mg t.i.5 mg/kg 7. 800 mg in the morning and 1.d.i.d mg t.i.8 0 0 500 mg once mg once daily daily 1.0 gm as a single dose 400 mg t. 100 or 400 mg t. t.d. 2 1 Invasive intestinal amoebiasis Extra intestinal amoebiasis (including liver abscess) and symptomless amoebic cyst passers Giardiasis 5 5-10 mg 200 mg 200 q.d.d.0 gm once 6 0 0 .d.d. 400–500 mg twice daily 2.i. Either 400 7. Acute gingivitis Acute infections ulcerative dental 3 3 -7 5-7 1 Bacterial vaginosis Leg ulcers and pressure sores Anaerobic infections 7 7 .i. t.i. t.d.i. t.i.d.i.d.d.d. 200 mg t.2 gm at night 2.5 mg/kg 7.d.d.i.d. mg 400 -800 mg 200 -400 mg 100-200 mg 100 -200 t.i.i.d A 3 2.i.d hours or 500 mg every 8 hours 100 mg 50 mg b.i.0 gm as a single dose 800 mg t.d t.i. Children 3-7 years 9 1-3 years mg Trichomoniasis** mg 100 mg 50 b.d.i. 5 ml/kg) 8 hourly. necrotizing pneumonia. For bacterial infections: Adults: 500 mg (100 ml) 8 hourly.5 mg/kg (1. Presentation: 400 mg Tablet.5 mg/kg 7. furred tongue. phenobarbitone. bacteraemia. Treatment for 7 days should be satisfactory for most patients.d. brain abscess. drowsiness. It is indicated in: 1.5 mg/kg 2 hours t. t. Indication: Amodis 500 IV is indicated in the prophylaxis and treatment of infections in which anaerobic bacteria have been identified. nicoumalone. nausea. Children: 7. peritonitis. Dosage & Administration: Amodis 500 IV should be infused intravenously at an approximate rate of 5 ml/min. puerperal sepsis. Drug Interaction: Metronidazole interacts with warfarin. pelvic cellulites. osteomyelitis. A Use in Pregnancy & Lactation: Not recommended during first & later trimesters. and post operative wound infections from which pathogenic anaerobes have ben isolated. phenytoin. t. up to 3 further doses of 400–500 mg may be given every 8 hours for high-risk procedures Side Effect: Metalic taste. b e f o r e surgery.5 mg/kg 7. Oral medication should be substituted as soon as feasible. pelvic abscess. vomiting. fluorouracil. Amodis® 500 IV Active Ingredient: Metronidazole.d.The treatment of septicaemia. Breast feeding should be delayed until 48 hours after discontinuing metronidazole in the mother.The prevention of postoperative infections due to anaerobic bacteria 2. but the physician might decide to prolong treatment. disulfiram.i. diarrhoea.10 Surgical prophylaxis Product Guide 400–500 mg 7. . lithium.i.d. 500 mg Tablet & 200 mg/5ml Suspension. cimetidine etc.i. rashes and mild reversible leucopenia may be observed during treatment. tingling pain or weakness in the hands or feet. 100 mg/2 ml Injection. pruritus. cimetidine. constipation. 11 Neck and back pain. seizures. Use is not recommended in nursing mothers since metronidazole passes into the breast milk. hypnotics.5 mg/kg (1. Other side Effects are unsteadiness. Carbamazepine. headache. warfarin etc. fever or chills. CNS stimulation. 100 mg SR Capsule. For acute pain an initial dose of 100 mg is required. vomiting. somnolence.lithium. tenderness. sore throat. Indication: Atherosclerotic disease (ischemic stroke.methadone. 100 mg Suppository. Use in Children: In children from the age of one year Tramadol can be given in a dose of 1-2 mg/kg body weight. Drug Interaction: Monoamine oxidase (MAO) inhibitors. Preparation: 50 mg Capsule. Dosage & Administration: Usual doses are 50-100 mg every four to six hours. Colic and spastic pain. myocardial infarction or established peripheral arterial disease).fluorouracil. Pain associated with osteoporosis.anaemia or other blood disorders. redness or swelling over vein in which the medicine is given. Cancer pain. liver disease. Anclog® Active Ingredient: Clopidogrel. headache. Use in pregnancy & lactation: Studies have not been done in humans. disease of nervous system. phenytoin. repeated 8 hourly Children: 7. Joint pain. centrally acting analgesics.5 ml/kg) 8 hourly. use is not recommended during the first trimester of pregnancy. Side Effect: Dizziness/vertigo. Drug Interaction: Metronidazole shows drug interaction with the following: alcohol or alcohol-containing beverages. however. A Anadol® Active Ingredient: Tramadol. Metronidazole has not been shown to cause birth defects in animal studies. carbamazepin.Product Guide For treatment before and during surgery: Adults: 500 mg (100 ml) shortly before operation. barbiturates. acute intoxication with alcohol. Precaution: Metronodazole should be given with caution in the following conditions. unusual tiredness or weakness. prophylactically in patients at the risk . Indication: Post-operative pain. asthenia. Use in Pregnancy and Lactation: Tramadol should be used during pregnancy only if the potential benefit justifies the risk to the foetus. disulfiram. pain. Preparation: 100 ml solution of Metronidazole for intravenous infusion. Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions. opioids or psychotropic drugs. vaginal irritation or discharge. Side Effect: Pain. numbness. seizures etc. Contraindication & Precaution: Hypersensitivity. skin itching. nausea. Active pathological bleeding such as peptic ulcer or intracranial hemorrhage or bleeding disorders Active Ingredient: Bupivacaine HCl & Dextrose Monohydrate. Use in Pregnancy and Lactation: Clopidogrel should be used in pregnant women and nursing mothers only if clearly needed. paraesthesia. nausea. Drug Interaction: Aspirin. myocardial infarction or acute coronary syndrome). pruritis. Active pathological bleeding such as peptic ulcer or intracranial hemorrhage. paraesthesia. vomiting. Dosage and Administration: Once daily. Recent gastrointestinal bleeding. It is not recommended for use during breast feeding because of the possible risk of developing Reye’s syndrome. Preparation: 75 mg Tablet. Side Effect: Hemorrhage. rash. nausea. Dosage and Administration: One tablet once daily. When injected in the L3-L4 intervertebral space with the patient in the sitting position. Product Guide like hemophilia. Indication: Spinal anesthesia for• Urological surgery (lasting 2-3 hours) • Lower limb surgery (lasting 2-3 hours) • Abdominal surgery (lasting 45-60 minutes) Dosage & Administration: Spinal anesthesia for surgery: 2-4 ml (10-20 mg Bupivacaine Hydrochloride). The spread of anesthesia obtained with Anespine depends on several factors including the volume of solution and the position of the patient during and following the injection. vertigo. 3 ml of Anespine spreads to the . Drug Interaction: This combination may enhance the Effect of anticoagulants. hepatic and biliary disorder. NSAIDs should be used with cautions to patients taking Clopidogrel. neutropenia may occur. rash.12 of thrombo-embolic disorders such as myocardial infarction and stroke. Use in Children: Safety and efficacy in the pediatric population have not been established. dizziness. vomiting. abdominal discomfort. pruritus. Use in Pregnancy and Lactation: The combination drug should be avoided during the last three months of pregnancy. Contraindication and Precaution: Hypersensitivity. history of Side Effect: Abdominal pain. headache. Contraindication and Precaution: Hypersensitivity to any of the components or NSAIDs. Preparation: (Clopidogrel 75 mg + Aspirin 75 mg)/Tablet A Anespine TM Anclog® Plus Active Ingredient: Clopidogrel + Aspirin Indication: Prevention of atherosclerotic events in patients with history of symptomatic atherosclerotic diseases (ischemic stroke. neuralgia. diarrhoea. Losartan potassium should not be used with potassium-sparing diuretics. The dose may be increased to 100 mg taken once daily. The following conditions preclude the use of spinal anesthesia: severe haemorrhage. the blockade spreads to T4-T7 spinal segments. those treated with highdose diuretics). Patients with hypovolemia due to any cause can develop sudden and severe hypotension during spinal anesthesia. Indication: All grades of hypertension and heart failure. With the patient receiving the injection in the horizontal position and then turned supine. There is no 13 evidence of untoward Effects in human pregnancy. lips and/ or tongue and serious hypotension (particularly on initiating treatment in saltdepleted patients) or renal failure (mainly in patients with renal artery stenosis) A . The Effects of Anespine exceeding 4 ml have not yet been studied and such volumes can therefore not be recommended. Angilock® Active Ingredient: Losartan Potassium. Contraindication & Precaution: Spinal anesthesia should only be undertaken by clinicians with the necessary knowledge and experience. Use in Children: Until further experience is gained in patients younger than 18 years. severe hypotension or shock and arrhythmias. Preparation: Intraspinal injection. In rare cases Bupivacaine has been associated with allergic reactions and anaphylactic shock. Side Effect: Dizziness.g. These conditions should be corrected prior to administer Losartan potassium or a lower starting dose (Usually 25 mg) should be used. dizziness and tremors. Angioedema involving swelling of the face. which severely restrict cardiac output. Dosage and Administration: 50 mg once a day. administration of Anespine in this age group is not recommended. Contraindication and Precaution: In patients who are intravenously volume depleted (e. each ml containing Bupivacaine HCl 5 mg & Dextrose Monohydrate 80 mg. A lower dose should be considered for patients with a history of hepatic and renal impairment. followed by convulsions and cardiovascular disorders. such as complete heart block. Use in Pregnancy & Lactation: Bupivacaine enters the mother’s milk but in such small quantities that there is generally no risk of affecting the child at therapeutic dose levels. It is also indicated to delay the progression of renal disease in patients with type 2 diabetes. Spinal anesthesia itself can cause hypotension and bradycardia due to sympathetic blockade and/or vasovagal fainting. Lightheadedness. It is contraindicated in patients with a known hypersensitivity to it or to any local anesthetic agent of the amide type. Side Effect: The safety of Bupivacaine is comparable to that of other local anesthetics used for spinal anesthesia. symptomatic hypotension may occur. It should be understood that the level of spinal anesthesia achieved with any local anesthetic can be unpredictable in a given patient. Systemic adverse reactions are characterized by numbness of the tongue. with protein in urine and hypertension.Product Guide T7-T10 spinal segments. rash. 5 mg.. Hyperuricemia may occur or frank gout may be precipitated in certain patients receiving thiazide therapy.5 one tablet once daily when Angilock Plus 50/12.14 may be encountered during Losartan potassium treatment. Palpitation. Dizziness. Rash. Management of Dosage and Administration: One tablet of Angilock Plus once daily. Cough. Sinusitis.5 mg. Edema/ swelling. Losartan potassium should not be used in lactating mother. 50 mg & 100 mg Tablet.5 is not adequate to control BP. amiloride). Hydrochlorothiazide : Alcohol. Indication: hypertension. Indication: Long-term angina pectoris. Hyperglycemia may occur with thiazide diuretics. Upper respiratory infection. taking into account the importance of the drug to the mother. Use in Pregnancy & Lactation: Because of the potential for adverse Effects on the nursing infant. triamterene. Back pain. anuria or hypersensitivity to other sulfonamide-derived drugs. Other antihypertensive drugs additive Effect or potentiation: Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Preparation: 25 mg. Use in Pregnancy & Lactation: Losartan potassium should not be used in pregnancy and if pregnancy is detected Losartan potassium should be discontinued as soon as possible. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. Product Guide be required. Trimetazidine treatment of . potassium supplements. spironolactone. Side Effect: Abdominal pain. Losartan potassium 100 mg + Hydrochlorothiazide 25 mg & Losartan potassium 100 mg + Hydrochlorothiazide 12. In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may Angivent® MR Active Ingredient: Hydrochloride. More than two tablets of Angilock plus once daily or more than one tablet of Angilock 100 plus once daily is not recommended. Preparation: Tablet: Losartan potassium 50 mg + Hydrochlorothiazide 12. Drug Interaction: No drug interaction of clinical significance has been identified. Drug Interaction: Losartan potassium : Concomitant use of potassium-sparing diuretics (e. Angilock® Plus A Active Ingredient: Losartan Potassium + Hydrochlorothiazide. or salt substitutes containing potassium may lead to increases in serum potassium. barbiturates or narcotics: potentiation of orthostatic hypotension may occur. a decision should be made whether to discontinue nursing or discontinue the drug. g. Contraindication and Precaution: Hypersensitive to any component of this product. Angilock Plus 100/12. d. Indication: Anleptic is indicated for • partial and secondary generalized tonicclonic seizures • primary generalized tonic-clonic seizures • trigeminal neuralgia • prophylaxis of bipolar disorder Dosage & Administration: Epilepsy: Adults and children over 12 years of age . If satisfactory clinical response has not been achieved.d. Trigeminal Neuralgia: Initial: On the first day.d. This daily dose may be increased by up to 200 mg/ day using increments of 100 mg every 12 hours for tablets or XR tablets. However.d. Children 6-12 years of age . for tablets or XR tablets. or t. or 50 mg (1/2 teaspoon) q.i. or 1 teaspoon q. Maintenance: usually 800-1200 mg daily. in the absence of clinical data and for safety reasons. for tablets and XR tablets. attempts should be made to reduce the dose to the minimum Effective level or even to discontinue the drug. for suspension (400 mg/day). No recommendation regarding the safety of Carbamazepine for use at doses above 35 mg/kg/24 hours can be made. optimal clinical response is achieved at daily doses below 35 mg/kg. except phenytoin.d. A total dose of 1200 mg daily shouldn’t be exceeded. some patients may be maintained on as little as 200 mg daily. the drug should be added gradually while the other anticonvulsants are maintained or gradually decreased. as tablets.i.i.Product Guide Dosage & Administration: 1 tablet at mealtimes in the morning and evening. Breastfeeding: In the absence of data. or q.Initial: Either 100 mg b.Initial: Either 200 mg b.i. as a precaution in the absence of currently available studies. At least once every 3 months throughout the treatment period. Preparation: 35 mg modified release Tablet. either 100 mg b. Use in Pregnancy and Lactation: Pregnancy: Studies in animals have not demonstrated a teratogenic Effect. for suspension. for suspension. breastfeeding is not recommended during treatment. severe renal failure (creatinine clearance <15 ml/min). Children under 6 years of age . When added to existing anticonvulsant therapy.i. only as needed to achieve freedom from pain. which may have to be increased. for a total daily dose of 200 mg. Maintenance: usually 400-800 mg daily. A Anleptic® Active Ingredient: Carbamazepine. Maintenance: Control of pain can be maintained in most patients with 400-800 mg daily.i. However.Initial: 10-20 mg/kg/day b.d. as suspension. or . or 1/2 teaspoon q. Combination therapy: Carbamazepine may be used alone or with other anticonvulsants.i.d. 15 1/2 teaspoon q. while others may require as much as 1200 mg daily. for tablets or XR tablets.d. plasma levels should be measured to determine whether or not they are in the therapeutic range. prescription should be avoided during pregnancy. The tablets or syrup can be taken without regards to meal.Maintenance: Ordinarily.i. Contraindication & Precaution: Severe depression.i.d. Side Effect: Rare cases of gastrointestinal disorders.i.d. for suspension (200 mg/day). Preparation: 200 mg Tablet. change in libido.anorexia. Indication: Mild to moderate anxiety. tranquilizers such as Diazepam and Alprazolam. fainting. nor have dosage guidelines been established for children 6 to 12 years. sedatives such as Secobarbital and Triazolam. bradycardia. tremors. inability to fall or stay asleep. Side Effect: More common side Effect includes drowsiness. Drug Interaction: Antihistamines such as Diphenhydramine.proteinuria. dry mouth. headache.leucopenia. Because of the potential serious side Effects. Older adults: The usual starting dose is 10 milligrams. if needed. nausea. liver problems. Not A Side Effect: Dizziness. vomiting. Use in Pregnancy & Lactation: recommended Preparation: 10 mg Tablet. yellowed eyes and skin. Dosage and Administration: Adult: . decision should me made whether to discontinue nursing or discontinue the drug. Contraindication: The drug is contraindicated in individuals who have an allergic reaction to Oxazepam or other benzodiazepines such as diazepam. heart failure and hypotension. convulsions.History of decreased blood cell production by the bone marrow (bone marrow depression).Carbamazepine and its epoxide metabolite are transferred to breast milk. Less common or rare side Effects include: Blood disorders. aplastic anemia may also be observed. dizziness. • Hereditary blood disorders called porphyrias. Severe Anxiety. vertigo. • People who have taken a monoamineoxidase inhibitor antidepressant (MAOI) in the last 14 days. excitement. loss or lack of muscle control. vomiting. sluggishness or unresponsiveness. drowsiness.16 Contraindication & Precaution: This medicine should not be used if anybody is allergic to one or any of its ingredients. or Alcohol Withdrawal: The usual dose is 15 to 30 milligrams. . Depression with Anxiety. 3 times a day. Children: Safety and Effectiveness have not been established for children less than 6 years of age. nausea. slurred speech. It can not be used also in the following conditions: • Problems with the electrical message pathways in the heart (atrioventricular block). skin rashes or eruptions. Use in Pregnancy & Lactation: Pregnancy category D. 100 mg/5 ml (100 ml) Suspension. Doctor may increase the dose to 15 milligrams 3 or 4 times a day. Erythematous skin rash. Product Guide Mild to Moderate Anxiety with Tension. Irritability and Agitation: The usual dose is 10 to 15 milligrams 3 or 4 times per day. eg amitriptyline. 3 or 4 times per day. • Allergy to tricyclic antidepressants. depressed mood. Side Effects due to rapid decrease or abrupt withdrawal from Oxazepam: Abdominal and muscle cramps. sweating. Anoxa® Active Ingredient: Oxazepam. tremors. swelling due to fluid retention. 200 mg CR Tablet. abdominal pain. ataxia. narcotic painkillers such as Oxycodone and Pethidine. Drug Interaction: Antihypertensive drugs.Product Guide 17 and persistent may occur immediately after use. Injection: The usual dose range is 10 200 mcg/min. cerebral haemorrhage and brain trauma. aspirin. Dosage & Administration: At the onset of an attack. Anril Spray may be used prophylactically 5 to 10 minutes prior to engaging in activities which might precipitate an acute attack. Also contraindicated in patients who are using sildenafil citrate since sildenafil citrate has been shown to potentiate the hypotensive Effects of organic nitrates. prompt medical attention is recommended. Only the smallest dose required for Effective control of the acute anginal attack should be used. hypotension. This drug should be used with caution in patients who may be volume-depleted or are already hypotensive. Use in Pregnancy & Lactation: Should be given to a pregnant woman only if clearly needed. If the chest pain persists. Contraindication & Precaution: Hypersensitivity to nitrates or any constituent of the formulation. Excessive use may lead to the development of tolerance. concomitant administration of phosphodiesterase inhibitors used for the treatment of erectile A . If the pain persists after a total of 3 tablets in a 15-minute period. weakness. Indication: Indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Contraindication & Precaution: Contraindicated in patients with early myocardial infarction. 1 or 2 metered sprays should be administered under the tongue. calcium channel blockers. Side Effect: Headache which may be severe Anril ® Spray Active Ingredient: Nitroglycerin. beta-adrenergic blockers. Dose up to 400 mcg/min may be required during some surgical procedures. dizziness. 2. Preparation: 0. mitral stenosis and angina caused by hypertrophic obstructive cardiomyopathy. 5 mg/ ml IV Injection. The dose may be repeated approximately every five minutes. No more than 3 metered sprays are recommended within a 15-minute period. phenothiazines. Anril® Active Ingredient: Nitroglycerin. alcohol. palpitation and other manifestations of postural hypotension may develop occasionally.6 mg SR (Sustained Release) Tablet. increased intracranial pressure and those with a known hypersensitivity to Nitroglycerin. Dosage and Administration: One tablet should be dissolved under the tongue at the first sign of an acute anginal attack. ergotamine and related drugs. prompt medical attention is recommended. Vertigo. hypovolaemia.5 mg Sublingual Tablet. until relief is obtained. severe anemia. It is not known whether nitroglycerin is excreted in human milk. Indication: Nitroglycerin Spray is indicated for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease. severe anaemia. Indication: Nasal congestion. seasonal & perennial allergic rhinitis . Dosage & Administration: The average range of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0. Omission of a meal or unplanned. nausea.0 IU/kg. Ansulin N Injection 40 IU/ml & 100 IU/ml. whereas in insulin resistant cases. 0. Few cases of the allergic reaction such as red and swollen or itching are reported. Nitroglycerin should be used with caution in patients with severely impaired renal or hepatic function. Hypoglycemia may occur if the insulin dose is too high in relation to the insulin requirement. Preparation: Ansulin R Injection 40 IU/ml &100 IU/ml. strenuous physical exercise may lead to hypoglycemia. Nitroglycerin should be given to pregnant women only if clearly needed.5 and 1.0 IU/kg. Initial dosages for type 2 diabetic patients are often lower.05%) in each nostril 1-2 times daily. facial flushing. Use in Pregnancy & Lactation: There are no restrictions on treatment of diabetes with insulin during pregnancy & lactation. reflex tachycardia etc. Preparation: 200 metered sprays (400 mcg/spray).g. Dosage and Administration: Adults: 2 or 3 drops adult formula (0.1%) 2-3 times daily. Use in Children: Safety and Effectiveness of nitroglycerin in pediatric patients have not been established.7 to 1. dizziness.g. may lead to hyperglycemia. during puberty or due to obesity. hypothyroidism. Contraindication & Precaution: Hypoglycemia or the patients who have allergic reaction to insulin or any of the excipients.6 IU/kg/day. malnutrition or hypothermia. Side Effect: Hypoglycemia is the most common adverse Effect during insulin treatment and symptoms of hypoglycemia may occur suddenly. Product Guide may be substantially higher. Children under 12 yrs : 1 or 2 drops children’s formula (0. vomiting. the daily insulin requirement Antazol ® Active Ingredient: Xylometazoline. sinusitis. Not to be used in infants .18 dysfunction. Nursing Mothers: Caution should be exercised when Nitroglycerin Spray is administered to a nursing woman. Use in Pregnancy and Lactation: Pregnancy : Pregnancy Category C. Ansulin 30/70 Injection 40 IU/ ml &100 IU/ml. Ansulin 50/50 Injection 100 IU/ml. It usually disappears in a few days. The use of Nitroglycerin during the early days of acute myocardial infarction requires particular attention to monitor hemodynamics and clinical status. A Ansulin® Active Ingredient: Insulin Human (rDNA) Indication: Type 1 & Type 2 Diabetes Mellitus.2 to 0. Inadequate dosing or discontinuation especially in type 1 diabetes. feelings of weakness. In pre-pubertal children it usually varies from 0. Side Effect: Headache. postural hypotension. e. e. Children: Up to 1 (one) year: 1 mg twice daily. Antazol Plus Active Ingredient: Sodium Cromoglycate and Xylometazoline. The ability to drive or operate machinery may be impaired.0325 mg)/spray. drowsiness and palpitations. Contraindication & Precaution: Patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater. motion sickness. dryness of the nose. dizziness. taken orally. Dosage & Administration: The recommended dose of Antiva in chronic hepatitis B patients with adequate renal function is 10 mg. sensitivity reactions. Indication: Allergic conditions including urticaria. Dosage and Administration: Adults (including the elderly) and children: one spray to each nostril four times daily. insomnia. Occasional irritation of the nasal mucosa. Dosage and Administration: Adults : 4 mg 3-4 times daily. vasomotor rhinitis. . Systemic cardiovascular Effects have occurred. Indication: Prophylaxis and treatment of allergic rhinitis accompanied by nasal congestion. local irritation. sneezing. Side Effect: No serious side Effects have been reported. hay fever.6 mg + 0. headache. headache. Preparation: (2. and this should be kept in mind when giving Antazol to people with cardiovascular disease. Side Effect: Drowsiness. Preparation: 2 mg/5 ml Syrup. Xylometazoline causes mild side Effects such as nasal irritation. hypersensitive to Xylometazoline. 1-5 yers: 1mg 3-4 times daily. 6-12 years: 2 mg 3-4 times daily or as directed by the physician. Side Effect: Burning sensation. wheezing and tightness of the chest has been reported. ® A Antiva® Active Ingredient: Adefovir Dipivoxil . Contraindication & Precaution: Known sensitivity to any ingredients of the preparation. glaucoma and hepatic disease. common cold.05% and 0. psychomotor impairment. headache. Metered Dose Nasal Spray. Preparation: 0. 19 Antista® Active Ingredient: Chlorpheniramine. Contraindication and Precaution: It should be used with caution in epilepsy. and dryness of the nasal mucosa. nausea. once daily.Product Guide less than 3 months. blurred vision and gastro-intestinal disturbances. angioneurotic oedema. urinary retention. Indication: Antiva is indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease. prostatic hypertrophy.1% Nasal Drops. dry mouth. cough. anorexia. III & IV dyslipidemia. headache. Preparation: 10 mg. Preparation: 10 mg Tablet. Apply the paste as soon as possible after noticing the symptoms of an aphthous ulcer. myalgia. . chest pain. 2. flatulence. Dosage range is Anzitor® 10 to 80 mg once daily. peripheral neuropathy. altered liver-function tests and gastrointestinal Effects including abdominal pain. Indication: For the treatment of Aphthous ulcers. Side-Effect: The most common side Effects of adefovir dipivoxil are weakness. IIb. apolipoprotein B. myopathy and hypersensitivity to the drug. preferably following oral hygiene after breakfast. LDLcholesterol. Thrombocytopenia. Dry the ulcer(s) by gently patting it with a soft. Severe acute exacerbations of hepatitis have been reported in patients who have discontinued anti-hepatitis B therapy.20 without regard to food. dinner. Contraindication & Precaution: Adefovir dipivoxil is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product. Reversible myositis. Dosage and Administration: Usual dose is 10 mg once daily. Active Ingredient: Atorvastatin. Fredrickson Type IIa. fibric acid derivatives. clean cloth. erythromycin. and at bedtime. alopecia. Use in Children: Safety in pediatric patients below 12 years of age is not established. Product Guide Side Effect: Side Effects are mild and transient. Indication: For reduction of elevated total cholesterol. azole antifungals. rash. diarrhoea. impotence. and triglycerides in patients with primary hypercholesterolemia (heterozygous familial & non familial). asthenia. paraesthesia. nausea and vomiting. hypoglycemia and hyperglycemia. Continue to use the paste four times daily. stomach pain and nausea. A Anzitor ® Apsol® Active Ingredient: Amlexanox. Use in Pregnancy and Lactation: Atorvastatin is contraindicated in pregnancy and while breast-feeding. Use in Pregnancy & Lactation: Adefovir dipivoxil should be used during pregnancy only if clearly needed and after careful consideration of the risks and benefits. headache. angioedema. Drug Interaction: Cyclosporin. Contraindication : Liver disease. 20 mg & 40 mg Tablet. rash and hypersensitivity reactions insomnia. pruritus. Dosage & Administration: 1. lunch. Mothers should be instructed not to breast-feed if they are taking adefovir dipivoxil. or niacin (nicotinic acid). Use in Pregnancy & Lactation: Pregnancy: US FDA pregnancy Category B. If significant healing or pain relief has not occurred in 10 days. directly to ulcers with the finger tips. nausea. Moisten the tip of the index finger. For children below 40 Kg dosage guideline is as follows: Body weight in Kg/ Body weight in lbs. Prophylaxis of Influenza: Aviflu is indicated for the prophylaxis of influenza in adult patients and adolescents 13 years and older. Wash hands when done applying. 21 Aviflu® Active Ingredient: Phosphate. Use the paste until the ulcer heals. 7.Product Guide 3. Dosage and Administration: Aviflu may be taken with or without food. Contraindication & Precaution: Amlexanox oral paste is contraindicated in patients with known hypersensitivity to Amlexanox or other ingredients in the formulation. therefore. Nursing Mothers: Amlexanox was found in the milk of lactating rats. 6. recommended dose is 75 mg twice daily for 5 days. consultation with the physician is required.5 cm) onto a finger tip. Treatment should be given within 2 days of onset of symptoms of influenza.Treatment of Influenza Adult & Adolescents: The recommended oral dose for treatment of influenza in adults and adolescents 13 years and older is 75 mg twice daily for 5 days. 8. This drug should be used during pregnancy only if clearly needed. Gently dab the paste on to the ulcer. In the event that a rash or contact mucositis occurs. stinging and/or burning at the site of application. Recommended Dose for 5 days A B o d y Body weight Recommendweight in in lbs ed Dose for 5 Kg days < 15 Kg < 33 lbs 30 mg twice daily > 15 Kg to > 33 lbs to 45 mg 23 Kg 51 lbs twice daily > 23 Kg to > 51 lbs to 60 mg 40 Kg 88 lbs twice daily Standard Dose . Use in Children: Safety and Effectiveness of Amlexanox oral paste in pediatric patients have not been established. 9. discontinue use. Wash eyes promptly if they should come in contact with the paste. Squeeze a dab of paste approximately 1/4 inch (0. 4. Side Effect: Adverse reactions reported by 1-2% of patients were transient pain. caution should be exercised when administering Amlexanox oral paste to a nursing woman.Prophylaxis of Influenza For adults and adolescents 13 years and . Infrequent (< 1%) adverse reactions in the clinical studies were contact mucositis. Wash hands before applying. Paediatric Dose: Children body weight more than 40 Kg. 5. and diarrhea. Standard Dose . Preparation: Tube containing 5 gm oral paste. Wash hands immediately after applying Amlexanox oral paste. Oseltamivir Indication: Treatment of Influenza: Aviflu is indicated for treatment of uncomplicated acute illness due to influenza infection in patients 1 year and older. Repeat the process if more than one ulcer. headache. Bronchitis. Dosage & Administration: Adults and adolescents (at least 12 years of age) : 1 tablet twice daily. unusual tiredness or weakness. or legs. cough. Safety and efficacy have been demonstrated for up to 6 weeks. Preparation: (150 mg Lamivudine and A Avudin® Active Ingredient: Zidovudine. stavudine. headache. sore throat. ribavirin. diarrhea. Side Effect: Common adverse events are nausea.22 older. Patients with Impaired Renal Function : Reduction of the dosages of Lamivudine and Zidovudine is recommended for patients with impaired renal function. dorsocervical fat enlargement (buffalo hump). recommended dose is 75 mg once daily for at least 7 days. nausea. Less common : Abdominal pain. The duration of protection lasts as long as dosing is continued. insomnia. vomiting. Oseltamivir be used only if the potential benefit for the lactating mother justifies the potential risk to the breast-fed infant. Because of the potential for HIV transmission and the potential for serious adverse Effects in nursing infants. Use in Pregnancy and Lactation: Pregnancy Category C. feet. Patients with HIV and Hepititis B virus co-infection: safety & efficacy not established. interferon-alpha. Therapy should begin within 2 days of exposure. Fat Redistribution: Redistribution/accumulation of body fat including central obesity. This drug should be used during pregnancy only if the potential benefits outweigh the risks. numbness. tingling. vomiting. fatigue are reported in rare cases. Drug Interaction: Lamivudine Exposure increase with : Trimethoprim/ sulfamethoxazole and zalcitabine. The recommended dose for prophylaxis during a community outbreak of influenza is 75 mg once daily. and cushingoid appearance have been observed in patients receiving antiretroviral therapy. Side Effect: More common: Chills. dizziness and trouble in sleeping may occur. Product Guide previously demonstrated clinically significant hypersensitivity to any of the components of the product. muscle tenderness and weakness. Lamivudine and Indication: Treatment of HIV infection. Use in Pregnancy and Lactation: Oseltamivir should be used only if potential benefit justifies the potential risk to the fetus. Contraindication & Precaution: Contraindicated in patients with . dizziness. yellow eyes or skin. fever. decreased appetite. burning. or pain in the hands. pale skin. vertigo. abdominal pain. facial wasting. Coughing. Contraindication: Oseltamivir is contraindicated in patients with known hypersensitivity to oseltamivir or any of the components of the product. Zidovudine Exposure increase with : Ganciclovir. diarrhea. skin rash. Preparation: 75 mg Capsule. following close contact with an infected individual. arms. peripheral wasting. and other bone marrow suppressive or cytotoxic. mothers should be instructed not to breast-feed if they are receiving this combination. breast enlargement. As with other antibacterial products. erythema. Use in Children: The safety and Effectiveness of Mupirocin have been established in the age range of 2 months to 16 years. B-50® Forte Active Ingredient: Vitamin B-complex. Indication: Barif is indicated for the chronic management of hyperuricemia in patients with gout. tenderness. Injection : 2 ml daily IV or IM. rash. Drug Interaction: Can decrease the efficacy of levodopa. beriberi polyneuritis. Drug Interaction: The Effect of the concurrent application of Mupirocin and other drug products has not been studied. Use in Pregnancy and Lactation: It is safe to use B-50® Forte in pregnancy and lactation. Dosage & Administration: Tablet/ Capsule : 1-2. Contraindication & Precaution: Hypersensitivity to the components. If a reaction suggesting sensitivity or chemical irritation should occur with the use of Mupirocin Ointment. Preparation: Tablet. 100 ml & 200 ml Syrup. Barif TM Active Ingredient: Febuxostat. stinging. dry skin. this drug should be used during pregnancy only if clearly needed. 3 times daily or as directed by the physician. cheilosis. including fungi. swelling. Syrup : 2-3 teaspoonful daily. 23 Contraindication & Precaution: In individuals with a history of hypersensitivity to any of its components. Preparation: 2 % Ointment. Indication: Glossitis. B B Bactrocin® Active Ingredient: Mupirocin. nausea.Product Guide 300 mg Zidovudine)/Tablet. When used on the face care should be taken to avoid the eyes. . The area treated may be covered with gauze dressing if desired. Side Effect: Burning. contact dermatitis. Side Effect: Rarely allergic reactions. Use in Pregnancy & Lactation: The drug is classified as Pregnancy Category B. stomatitis. Dosage & Administration: A small amount of ointment should be applied to the affected area three times daily. and increased exudate. Thus. Capsule. treatment should be discontinued and appropriate alternative therapy for the infection should be instituted. itching . prolonged use may result in overgrowth of nonsusceptible organisms. pain. Injection. Indication: Topical treatment of impetigo due to Staphylococcus aureus and Streptococcus pyogenes. Caution should be exercised when it is administered to a nursing woman. The usual starting dose is 100 micrograms twice daily Beclometasone. three or four times daily in accordance to the response. Product Guide It is not known whether this drug is excreted in human milk. The recommended starting dose of Barif is 40 mg once daily. Side Effect: The most common adverse events associated with the use of Febuxostat may include liver function abnormalities. Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents. Care is necessary in patients B Cardiovascular Events: A higher rate of cardiovascular thromboembolic events was observed in patients treated with febuxostat than allopurinol in clinical trials. . Barif 80 mg is recommended. Prophylactic therapy may be beneficial for up to six months.24 Dosage & Administration: Barif is recommended at 40 mg or 80 mg once daily. Caution should be exercised when Febuxostat is administered to a nursing woman. The use of Beclometasone dipropionate in mothers breast feeding their babies requires that the therapeutic benefits of the drug be weighed against the potential hazards to the mother and baby. Liver Enzyme Elevation: Transaminase elevations have been observed in febuxostat -treated patients. 100 micrograms or 200 micrograms twice daily should be given. nausea. Use in Children: The safety and efficacy of Febuxostat in children (under 18 years of age) has not been established. mercaptopurine. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg. In more severe cases the starting dose may need to increase to 600 to 800 micrograms per day. Children: 50 to 100 micrograms should be given two. Dosage & Administration: Adults (including the elderly): The usual starting dose is 200 micrograms twice a day. Alternatively. and rash. or theophylline. arthralgia. including Febuxostat. Use in Pregnancy & Lactation: Pregnancy Category C: Febuxostat should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. If a gout flare occurs during treatment. Indication: Preventive treatment for asthma. Contraindication & Precaution: Febuxostat is contraindicated in patients being treated with azathioprine. Febuxostat need not be discontinued. 80 mg Beclomin TM HFA Inhaler Active Ingredient: Beclometasone. Use in Pregnancy and Lactation There is inadequate evidence of safety in human pregnancy. Contraindication & Precaution: Contraindicated in patients with known sensitivity. Drug Interaction: Concomitant administration of Febuxostat with azathioprine. Preparation: 40 mg tablet & tablet. mercaptopurine or theophylline could increase plasma concentrations of these drugs resulting in severe toxicity. Side Effect: Anaphylactic reactions rarely Benzapen® Active Ingredient: Benzathine Penicillin. cataract reported. unpleasant taste & smell and epistaxis.3 to 1. Severe deficiency. dryness and irritation of the nose and throat.10 to 25 mg daily. Indication: Penicillin-sensitive infections. sprays. . 25 acute otitis media.3 to10 mg daily. syphilis. Nasal Spray. Contraindication and History of hypersensitivity. Drug Interaction: No potentially hazardous interactions have been described.200 to 300 mg daily.2 million units up to 2. Dosage & Administration: Prophylaxis. diphtheria carriers and prophylaxis against rheumatic fever and streptococcal infections. Side Effect: Candidiasis of the mouth and throat (thrush) occurs in some patients. Use in Pregnancy and Lactation: Benzapen injection should not be administered during pregnancy unless clearly indicated. Dosage and Administration: 0.Product Guide with active or quiescent pulmonary tuberculosis. acute. should not be used in infants. Beovit® Active Ingredient: Thiamine HCl. life-threatening anaphylactic reactions are rare. Mild chronic deficiency. Dosage and Administration: Adults : 02 sprays in each nostril twice daily.Nasal septum perforation. Preparation: 50 mcg/spray. Precaution: B Side Effect: Rare. Children under 6 years of age : Not recommended. Children (6 to 12 years of age) : 01 spray in each nostril twice daily. 200 puffs. Preparation: 12 lac units/vial Injection. neuritis associated with pregnancy and pellagra. Becospray® Active Ingredient: Beclomethasone. wheezing. Contraindication & Precaution: There is no absolute contraindication. Side Effect: Sensitization and allergic reactions. Preparation: HFA Inhaler : 50 or 100 or 250 mcg/puff . but they do occur. Contraindication & Precaution: History of Penicillin hypersensitivity. Drug Interaction: None is known. Indication: Seasonal & perennial allergic rhinitis including hay fever & non-allergic (vasomotor) rhinitis. Indication: Beriberi and Wernick’s encephalopathy.4 million units as a single dose repeated every five to seven days. B Indication: Eczema. Preparation: 10 gm Cream. Pyridoxine. fungal or viral skin lesions. children. Pyridoxine Hydrochloride 2 mg.26 occurs. Use in Pregnancy Recommended. Riboflavin. and no Active Ingredient: Betamethasone Dipropionate & Neomycin Sulphate. neurodermatoses. Drug Interaction: No hazardous drug interactions have been reported. specially when scondary bacterial infection is present. psoriasis. Children : 10 ml (2 teaspoonfuls) 1 to 3 times daily. Riboflavin 2 mg. Contraindication & Precaution: Untreated bacterial. systemic steroid therapy in generalized erythroderma. reducing frequency as condition responds. Preparation: 100 mg Tablet. Drug Interaction: Generally interactions have been observed. sufficient systemic absorption to produce Lactation: Preparation: (Thiamine Hydrochloride 5 mg. care is needed to ensure that the preparation does not enter the eye. Nicotinamide and Zinc Indication: Treatment and prevention of B-vitamins and Zinc deficiencies. Dosage & Administration:Apply sparingly 2-3 times daily.acne and perioral dermatitits. Use in Pregnancy and Lactation: The drug may be given safely to neonates. Side Effect: Local atrophic changes in the skin such as thinning. and dilatation of the superficial blood vessels. Dosage and Administration: Bicozin Syrup : Adults : 10 ml (2 teaspoonfuls) 2 to 3 times daily. If applied to the eyelids. Side Effect: Generally well tolerated. Use in Pregnancy and Lactation: Topical administration of corticosteroids to pregnant animal can cause abnormalities of fetal development including cleft palate and intrauterine growth retardation and fetal ototoxicity. Bicozin Tablet : Adults & Children over 30 kg : 1 to 2 tablets 2 to 3 times daily Contraindication: In patients with a known hypersensitivity to any of the ingredients of this product. Product Guide the features of hypercorticism and suppression of the HPA axis. contact sensitivity reactions. Betameson-N ® Bicozin® Active Ingredient: Thiamine. Riboflavin . Transient mild soreness might happen. Nicotinamide 20 mg and elemental Zinc 10 mg)/5 ml Syrup. as glaucoma might occur. Infants: 5 ml (1 teaspoonful) 1 to 2 times daily. prurigo nodularis. particularly in infants and children. seborrhoeic dermatitis. Thiamine Mononitrate 5 mg. striae. secondarily infected insect bites and anal and genital intertrigo.Longterm continuous topical therapy should be avoided where possible. pregnant and lactating women and elderly patients. a few side-Effects of oral Iron preparations. Bisocor 2.) and concomitant administrations of medicaments (tetracyclines. Side Effect: Bicozin-I syrup is generally well tolerated. Thiamine Hydrochloride BP 5 mg. Pyridoxine Hydrochloride BP . patients with a history of severe anaphylactic reaction to a variety of allergens may be more B Drug Interaction: No interactions have been observed. Contraindication & Precaution: Bicozin-I syrup is contraindicated in patients with a known hypersensitivity to any of the ingredients of this product. Risk of anaphylactic reaction: While taking beta-blockers. constipation or diarrhoea may occur. Nicotinamide BP and Zinc Sulphate Heptahydrate BP. Since. Dosage & Administration: Adults: 5 ml10 ml (1-2 teaspoonful) 3 times daily or as recommended by the physician. antacids) are . the Iron is complex bound. and marked sinus bradycardia. the dose may be increased to Bisocor 10 mg and then. etc. 27 Bicozin-I® Active Ingredient: Iron (III) Hydroxide Polymaltose Complex INN . second or third degree AV block. If the antihypertensive Effect of Bisocor 5 mg is inadequate. Riboflavin-5-Phosphate Sodium BP 2. Contraindication & Precaution: Bisoprolol is contraindicated in patients with cardiogenic shock. Bisocor® Active Ingredient: Bisoprolol Fumarate. However. Indication: Bisocor (Bisoprolol) is indicated in the management of hypertension and in the treatment of angina.5 mg may be an appropriate starting dose. In some patients. Impaired renal or hepatic function: Use caution in adjusting the dose of Bisoprolol in patients with renal or hepatic impairment. The usual starting dose is Bisocor 5 mg once daily. Dosage & Administration: The dose of Bisocor must be individualized to the needs of the patient. Nicotinamide 20 mg & elemental Zinc 10 mg/Tablet. Indication: Bicozin-I syrup is indicated for the treatment and prevention of Iron. overt cardiac failure. Riboflavin-5-Phosphate Sodium BP .97 mg equivalent to elemental Zinc 10 mg/5 ml (100 & 200 ml). Nicotinamide BP 20 mg and Zinc Sulphate Heptahydrate BP 43.33 ml/kg body weight daily or as recommended by the physician. tannin. oxalates. It may be used alone or in combination with other antihypertensive agents. unlikely to occur. Pyridoxine Hydrochloride 2 mg.Product Guide 2 mg. ionic interaction with foodstuff components (phytates. if necessary. vomiting. Children: 5 ml (1 teaspoonful) 3 times daily or as recommended by the physician. Infants: 0. Use in Pregnancy Recommended. B-vitamins and Zinc deficiencies. to 20 mg once daily. including nausea. Pyridoxine Hydrochloride BP 2 mg. & Lactation: Preparation: Iron (III) Hydroxide Polymaltose Complex INN 200 mg equivalent to elemental Iron 50 mg.74 mg equivalent to Riboflavin 2 mg. Thiamine Hydrochloride BP . bradycardia. sleep disturbance. Lactation: It is not known whether this drug is excreted in human milk.5 mg and Hydrochlorothiazide BP 6. .28 reactive torepeated challenge. dyspepsia. B Side Effect : Fatigue. pharyngitis etc. muscle pains or cramps. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. orthostatic hypotension. accidental. weakness. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth. diarrhoea.5 to 50 mg.5 to 40 mg. Hypokalemia may develop. claudication. In clinical trials of Bisoprolol/ Hydrochlorothiazide combination therapy using Bisoprolol doses of 2. Use in Pregnancy and Lactation: Pregnancy: Bisoprolol should not be used during pregnancy unless clearly necessary.5 to 20 mg and Hydrochlorothiazide doses of 6. e. Patients should be carefully observed. headache. breast-feeding is not recommended during administration of Bisoprolol. Contraindication: It is contraindicated in patients in cardiogenic shock. hands and feet. . arrhythmia.g. dizziness. 5 mg & 10 mg tablet Bisocor Plus TM Active Ingredient: Bisocor Plus 2. restlessness. hypotension.5/6. anuria and hypersensitivity to either component of this product or to other sulfonamidederived drugs. slower than normal heart beat (bradycardia). marked sinus bradycardia. it should be achieved gradually over a period of about 2 weeks. oliguria. nausea. peripheral ischemia. muscular fatigue. vomiting. muscle weakness or cramps. Indication: Management of hypertension. constipation. lethargy. cold extremities. disturbances of the gut such as nausea.5 mg. Product Guide Dosage & Administration: Bisoprolol is an Effective treatment of hypertension in once-daily doses of 2. chest pain.25 to 25 mg. dizziness. drowsiness. Bisocor Plus 5/6.25 mg. tachycardia and gastrointestinal disturbances such as nausea and vomiting. Side Effect: Generally well tolerated. breathing difficulties due to a narrowing of the airways (bronchospasm) in people with asthma or COPD. thirst. Therefore. diarrhoea.25 mg. rhinitis. rhythm disturbances. the antihypertensive Effects increased with increasing doses of either component. headache. If withdrawal of this combination therapy is planned. Side Effects which may occur: fatigue.25 tablet: Each film coated tablet contains Bisoprolol Fumarate USP 2. If treatment with Bisoprolol is considered necessary. palpitations. Preparation: 2. diagnostic or therapeutic. Most side Effects have been mild and transient. the uteroplacental blood flow and the foetal growth should be monitored. Precaution: Hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics. constipation or abdominal pain. cold or numb extremities. worsening of heart failure.25 tablet: Each film coated tablet contains Bisoprolol Fumarate USP 5 mg and Hydrochlorothiazide BP 6. while Hydrochlorothiazide is Effective in doses of 12. second or third degree AV block. overt cardiac failure. depression. Preparation: 10 mg/5 ml Syrup. Dosage and Administration: Adults and Children over 12 years: 15 to 30 mg 3-4 times per day.5/6.25 tablet: Bisoprolol Fumarate 2. Acromegaly. There are no adequate and well-controlled studies in pregnant women. Side Effect: Rare. Indication: Chronic dry cough/ unproductive cough. Concomitant use can increase the risk of bradycardia.25 mg Bisocor Plus 5/6. infertility or hypogonadism. Preparation: Bisocor Plus 2. In patients receiving concurrent therapy with clonidine.25 mg. it is suggested that this combination drug be discontinued for several days before the withdrawal of clonidine. B Bromolac TM Active Ingredient: Bromocriptine. Drug Interaction: Two fatal interactions have been reported in patients taking therapeutic doses of phenelzine and dextromethorphan. Bisoprolol Fumarate and Hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus. such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic agents. 29 Brofex® Active Ingredient: Dextromethorphan. Children between 2 .Product Guide Drug Interaction: This combination drug may potentiate the action of other antihypertensive agents used concomitantly. confusion and respiratory depression may occur after overdosage.5 mg+ Hydrochlorothiazide 6.25 tablet: Bisoprolol Fumarate 5 mg+ Hydrochlorothiazide 6. Excitation.6 years : 2. Dosage & Administration: General: It . Parkinson’s Disease. This combination drug should not be combined with other beta-blocking agents. Children between 6-12 years : 5-15 mg up to 4 times per day. Use in Nursing Mothers: Bisoprolol Fumarate alone or in combination with Hydrochlorothiazide has not been studied in nursing mothers. such as reserpine or guanethidine. such as disopyramide.5-5 mg up to 4 times per day. are used concurrently. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. This combination drug should be used with caution when myocardial depressants or inhibitors of AV conduction. if therapy is to be discontinued. Contraindication & Precaution: Concomitant use of MAO inhibitors is contraindicated with Dextromethorphan. Use in Pregnancy & Lactation: Pregnancy Category C. Prolactin-secreting adenomas. Acute dry cough which is interfering with normal function or sleep. should be closely monitored because the added betaadrenergic blocking action of Bisoprolol Fumarate may produce excessive reduction of sympathetic activity. Patients receiving catecholamine-depleting drugs. but nausea and dizziness sometimes occur. Indication: Dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea. pimozide.5 mg tablet daily. butyrophenones. When control has been achieved. Use in Children: No data are available for bromocriptine use in pediatric patients under the age of 8 years. They are also indicated in the symptomatic treatment of severe chronic obstructive pulmonary disease (COPD). Nursing Mothers: Bromocriptine should not be used during lactation in postpartum women. haloperidol. An additional 2.5 mg Tablet. constipation. Side Effect: The incidence of adverse Effects are: nausea .5 mg should be added to the treatment regimen as tolerated every 3-7 days until patient obtains optimal therapeutic benefit. headache.5 mg tablet twice daily with meals.5 mg to 3. with a history of repeated exacerbations despite regular therapy with long-acting bronchodilators. Care should be exercised when administering Bromocriptine therapy concomitantly with other medications known to lower blood pressure.5 mg tablet may be added to the treatment regimen as tolerated as tolerated every 2-7 days until an optimal therapeutic response is achieved. For Bufocort there are two treatment approaches (A) Maintenance Therapy: Patients should be advised to have their separate rapid acting bronchodilator available for rescue use at all times. Acromegaly: The initial recommended dosage is 1. the dose should be titrated to the lowest Effective dose. Bufocort TM B Active Ingredient: Budesonide Formoterol Fumarate Dihydrate. and Indication: Bufocort Cozycaps are indicated in the regular treatment of asthma. diarrhea and drowsiness. Prolactinomas:2. An additional 1. Drug Interaction: Bromocriptine may interact with dopamine antagonists.25 mg of a 2. A slight hypotensive Effect may accompany treatment. Dosage & Administration: Asthma : Dosage is individual and should be adjusted according to disease severity.25 mg to 2.75 mg daily Inhibition of lactation:5 mg (1 tablet twice) daily with morning & evening meals for 14 days Contraindication & Precaution: Safety and efficacy of bromocriptine mesilate have not been established in patients with renal or hepatic disease. fatigue.25 to 2. nasal congestion . Hyperprolactinemic Indications: The initial dosage is 1. vomiting . and certain other agents.5 mg on retiring (with food) for 3 days. lightheadedness. dizziness. abdominal cramps.30 is recommended that Bromocriptine mesilate be taken with food.25 to 2. . Parkinson’s Disease:The initial dose of Bromocriptine mesilate is 1. Compounds in these categories result in a decreased efficacy of Bromocriptine: phenothiazines. Patients should be evaluated frequently during dose escalation to determine the lowest dosage that produces a therapeutic response. Product Guide metoclopramide. Preparation: 2. Concomitant use of Bromocriptine with other ergot alkaloids is not recommended. Use in Pregnancy & Lactation: Pregnancy Category B. maximum dose is 2 Cozycaps. Use in Pregnancy & Lactation: Administration of Bufocort Cozycaps in pregnant women and lactating mother should only be considered if the expected benefit is greater than any possible risk to the foetus. B Burna® Active Ingredient: Silver Sulfadiazine. Contraindication: It is contraindicated in patients who are hypersensitive to it or any of the other ingredients in the preparation. maximum dose is 4 Cozycaps. and headache have been reported. (B) Single Maintenance and Reliever Therapy (For Bufocort -100 and 200 only) Patients take a daily maintenance dose of Bufocort and in combination take Bufocort as needed in response to symptoms. COPD (Chronic Obstructive Pulmonary Disease) Bufocort 200 Cozycaps: 2 Cozycaps . Patients should be advised to always have Bufocort available for use. cardiac arrhythmias. Contraindication & Precaution: Bufocort Cozycaps are contraindicated in patients with a history of hypersensitivity to any of the components of the drug product. . rashes. Preparation: 100. an additional Cozycap should be taken.5 mm. tremor. twice daily. twice daily. Dosage & Administration: Once to twice daily to a thickness of approximately 1/16 inches or 1. Patients should take 1 additional Cozycap as needed in response to symptoms. twice daily.100 / 200 Cozycaps: 1-2 Cozycaps. oedema and angio-oedema can occur in some patients. twice daily. Side Effect: Several cases of transient leukopenia have been reported in-patients receiving Silver Sulfadiazine therapy. Bufocort . Children (6-11 Years) Bufocort . Other infrequently occurring events include skin necrosis. Indication: The topical prophylaxis against bacterial colonization and infection in burn wounds. diabetes mellitus. including heart rhythm abnormalities.400 Cozycaps: 1 Cozycaps. or thyrotoxicosis. It should be administered with caution in patient with severe cardiovascular disorders.200 Cozycaps: 1 Cozycap. Not more than 6 Cozycap s should be taken on any single occasion.100/200 Cozycaps: 1-2 Cozycaps. skin discoloration. twice daily. Bufocort . twice daily. 31 Side-Effect: Hoarseness and candidiasis (thrush) of the mouth and throat. burning sensation.400 Cozycaps: 1 Cozycap. twice daily. If symptoms persist after a few minutes. untreated hypokalaemia. Use in Children:Safety in pediatric patients below 6 years of age is not established. twice daily. Adolescents (12-17 Years) Bufocort . including rash.Product Guide Adults (18 Years and Older) Bufocort . 200 and 400 Cozycap. Cutaneous hypersensitivity reactions. muscle cramps and hypersensitivity reactions. erythema multiform. palpitations. Indication: Cadnyl (Perindopril) is a long-acting ACE (Angiotensin Converting Enzyme) inhibitor and is indicated in. mentagrophytes. depending on renal. fatigue.32 and interstitial nephritis. . T. Butefin Cream should be applied twice daily for 7 days or once daily for 4 weeks. tinea corporis (ringworm). Indication: Butefin Cream is indicated for the topical treatment of the following superficial dermatophytes: tinea pedis (athlete’s foot). Use in Children: Safety and efficacy in pediatric patients below the age of 12 years have not been studied. Stable coronary artery disease. Elderly patients: Start treatment at Perindopril 2 mg daily. Dosage and Administration: Hypertension: One Cadnyl 4 tablet once daily preferably in the morning. Patients with tinea corporis or tinea cruris should apply Butefin Cream once daily for 2 weeks. Preparation: 1% cream. Butefin® Active Ingredient: Butenafine HCl 1%. then increased to 8 mg once daily. It is not known if Cadnyl® Active Ingredient: Perindopril Erbumine. Pregnancy and Lactation: Pregnancy Category C. furfur. Drug interaction: Potential drug interactions between butenafine HCl cream and other drugs have not been evaluated. rubrum. Product Guide butenafine HCl is excreted in human milk. Caution should be exercised in prescribing butenafine HCl to a nursing woman. asthenia. floccosum. If necessary dose may be increased to 4 mg. T. headache. Congestive heart failure: Cadnyl should be started under close medical supervision at a starting dose of 2 mg in the morning. Perindopril should be taken before food. Patients with tinea (pityriasis) versicolor should apply Butefin Cream once daily for 2 weeks. Use in Pregnancy and Lactation: Pregnancy Category : B Nursing Mother: It is not known whether Silver Sulfadiazine is excreted in human milk. Contraindication: Contraindicated in individuals who have known or suspected sensitivity to butenafine HCl cream or any of its components. Essential hypertension. Side Effect: Usually at the start of treatment cough. Preparation: 1% Cream. T. and tinea cruris (jock itch) due to E. then Cadnyl 4 once daily the next week. depending on renal function and provided that the 4 mg dose is well tolerated. Congestive heart failure. Stable coronary artery disease: Cadnyl 4 once daily for two weeks. Dosage and administration: For the treatment of interdigital tinea pedis. the dose may be increased to 8 mg after 1 month of treatment.If necessary. function. before increasing the dose up to 8 mg once daily. . tonsurans and tinea (pityriasis) versicolor due to M. disturbances of mood and/or C . Elderly patients should receive Perindopril 2 mg once daily for one week. with mild or moderate impairment of renal function or with a Calbo® 500 Active Ingredient: Calcium Carbonate. Use in Elderly: Monitoring of serum calcium and phosphate is of course indicated for elderly patients. Zollinger-Ellison syndrome. Preparation: 4 mg Tablet. tetracycline. Adjuvant in colds and influenza. Treatment of calcium and vitamin C deficiency. C C . Osteoporosis. e. Hypercalcaemia. Use in Pregnancy and Lactation: Perindopril should not be used during pregnancy & lactation. For patients with mild hypercalciuria (exceeding 300 mg = 7. Use in Pregnancy and Lactation: Calcium containing drugs have been widely used in pregnancy by way of oral calcium supplementation or antacid therapy. Dosage and Administration: Calbo (5001500 mg calcium) daily is recommended. Postmenopausal problems. Severe renal failure. Contraindication and Precaution: Hypercalcemia. pregnancy. Indication: the treatment or prevention of calcium depletion. Iron overload. Concomitant digoxin therapy (requires careful monitoring of serum calcium level). Preparation: Calcium 500 mg Tablet. Drug Interaction: Digoxin and other cardiac glycosides.Increased demand for Calcium and Vitamin C. Severe hypercalciuria.6 . Premenstrual syndrome.5 mmol/24 hours). Calcium Carbonate and Ascorbic Acid (Vitamin C) Indication: Indicated in . Patients with hyperoxalauria. lactation. Contraindication: Perindopril is contraindicated in patients with a history of hypersensitivity to Perindopril. Vitamin D & primary phosphate binder. During infectious disease and convalescence.phosphate dehydrogenase deficiency. periods of rapid growth (childhood. Calcium Carbonate can be used in lactating women too. Children 3 to 7 years : 1/2 effervescent tablet daily. adolescence). Calbo-C® Active Ingredient: Calcium Lactate Gluconate. Dissolve one tablet in half glass (100 ml) of water. Hypercalciuria and nephrolithiasis. Dosage and Administration: Adults and children of school age :1 effervescent tablet daily. Infants : As prescribed by the physician. in old age. Contraindication and Precaution: Hypercalcaemia and hyperparathyroidism. Side Effect: Constipation. 33 Use in Children: Calcium Carbonate has been extensively studied in children and infants with chronic renal failure and is both safe and effective. Glucose .g.Product Guide sleep have been reported. Larger doses may lead to gastrointestinal tract upset. Use in Children: Contraindicated in case of management of hypertension of Children. lactation. Product Guide Dosage and Administration: Adults. Vitamin C enhances iron absorption. Active Ingredient: Calcium + Vitamin D. Doxycycline. Nitrofurantoin. Potentially useful interactions: Vitamin D. Increased demand for Calcium. Indication: Indicated in . C Drug Interactions: It has possible interaction with digoxin. Indication: Calcium and Vitamin D is used for the treatment of osteoporosis. aminocycline or oxytetracycline etc. . Frusemide. Use in Pregnancy and Lactation: Calcium containing drugs have been widely used in pregnancy by way of oral calcium supplementation or antacid therapy. elderly and children: 1 tablet in the morning and 1 tablet at night. and parathyroid disease. It is also used as routine supplement and phosphate binder in chronic renal failure. nausea. calcitriol or other Vitamin D supplements.34 history of urinary concrements. High doses of Vitamin D and derivatives should be avoided during treatment with this preparation unless especially indicated. Erythromycin. Drug Interaction: Potentially hazardous interactions: Digoxin. Vitamin C may be taken safely during pregnancy and lactation.g. the dosage should be reduced or therapy should be discontinued.)/Tablet. other calcium supplements. pregnancy. monitoring of calcium excretion in the urine is required. osteomalacia. Calcium Carbonate. Side Effect: Also there may be allergic reactions. Oxytocin and Prostaglandins. Aminophylline. If necessary. Calcium Carbonate 327 mg and Ascorbic Acid (Vitamin C) 500 mg Effervescent Tablet. So before taking any of these drugs consultations of the physicians are needed. rickets. Tetracycline. antacids containing calcium. tetany. decreased appetite dry mouth and drowsiness. Vitamin-C and Vitamin-D. Calcium Carbonate can be safely used in lactating women. e.As an adjunct to specific therapy for osteoporosis. tetracycline. vomiting. Ascorbic Acid (Vitamin-C) and Vitamin-D3. Preparation: Calcium Lactate Gluconate 1000 mg.U. Conjugated estrogens. Uses in Pregnancy & Lactation: It should be used as directed by the physician during pregnancy and lactation. irregular heartbeats. Chloramphenicol. Calbo-D ® Calbo® Forte Active Ingredient: Each effervescent tablet contains Calcium Lactate Gluconate. aluminum or magnesium. Side Effect: In rare case bloating and diarrhea can occur. Contraindication and Precaution: •H ypercalcemia and hyperparathyroidism • Hypercalciuria and nephrolithiasis • Hypersensitivity to the component of this preparation • Severe renal insufficiency. In predisposed patients prolonged treatment with high doses may promote the formation of calculi in the urinary tract. Preparation: (Calcium 500 mg + Vitamin D 200 I. Pentagastrin. the dosage should be reduced or therapy should be discontinued. Dosage and Administration: Children : 1 tablet daily. Larger doses may lead to gastrointestinal tract upset. Premenstrual syndrome. Ascorbic Acid (Vitamin-C) BP 500 mg and Vitamin-D (as Vitamin-D3) BP 400 I. Since citrate salts have been reported to increase aluminium absorption. inadequate intake of calcium in the diet due to malnutrition. this preparation which contains citric acid as a constituent. Following administration of vitamin-D supplements occasional skin rash has been reported. Contraindication & Precaution: Hypercalcemia. For patients with mild hypercalciuria (exceeding 300 mg = 7. monitoring of calcium excretion in the urine is required. Osteoporosis. Hypercalciuria and in rare cases hypocalcaemia have been seen in long term treatment with vitamin-D at high doses. adolescence). latent tetany and during pregnancy and lactation. Side Effect: In rare case. bone metastasis or other malignant bone disease. Adults : 2 tablets daily or as directed by the physician Contraindication & Precaution: . Adolescents: 1-2 tablets daily. severe renal failure. in old age.Product Guide periods of rapid growth (childhood. should be used with caution in patients with severely impaired renal function. disorders of osteogenesis and tooth formation (in addition to specific treatment).requirements for calcium and vitamin-D are increased but in deciding on the required supplementation allowances should be made for availability of these agents from other sources. especially those receiving aluminiumcontaining preparations. Postmenopausal problems. Use in Pregnancy & Lactation: During pregnancy and lactation treatment with Calbo Forte should always be under the direction of a physician. Calcium Carbonate BP 327 mg. During infectious disease and convalescence. mild gastrointestinal disturbances (bloating. If necessary. During pregnancy and lactation.In predisposed patients prolonged treatment with high doses may 35 promote the formation of calculi in the urinary tract. diarrhea) can occur. sarcoidosis. Indication: Raised calcium requirement for children and adolescents at times of rapid growth. with mild or moderate impairment of renal function or with a history of urinary concrements. glucose .U. iron overload. severe hypercalciuria. Adjuvant in colds and influenza Dosage & Administration: Adults and children of school age: 1 effervescent tablet daily Children 3 to 7 years: ½ effervescent tablet daily Infants: As prescribed by the physician Dissolve one tablet in half glass (100 ml) of water.phosphate dehydrogenase deficiency.5 mmol/24 hours). patients with hyperoxalauria. prevention and treatment of osteoporosis. vitamin-C & vitamin-D deficiency. vitamin-D overdosage. primary hyperparathyroidism. C Calbo® Jr Active Ingredient: Calcium Carbonate. Preparation: Each effervescent tablet contains Calcium Lactate Gluconate 1000 mg. Treatment of calcium.6 . It is best taken with or just after main meals with a full glass of water.g. calcitriol or other Vitamin D supplements. Drug Interaction: Tetracycline. fluoride preparations. Calcium salts should be used cautiously in patients with sarcoidosis. Severe renal insufficiency. Hypercalciuria and nephrolithiasis. Hypercalcemia. • For the treatment of established . Side Effect: Orally administered Calcium Carbonate may be irritating to the GI tract. Drug Interactions: It has possible interaction with digoxin. milk and milk products). antacids containing calcium. + Magnesium 40 mg + Manganese 1. Severe renal insufficiency. Use in Pregnancy & Lactation: It should be used as directed by the physician during pregnancy and lactation. High doses of Vitamin D should be avoided during calcium therapy unless specifically indicated. C Calboplex® Active Ingredient: Calcium. aluminum or magnesium. Product Guide Dosage and Administration: 1 tablet twice daily. It is also indicated for bone development and constant regeneration of bone. Calcium Carbonate can be safely used in lactating women. and in patients receiving cardiac glycosides. spinach. Use in Pregnancy and Lactation: Calcium containing drugs have been widely used in pregnancy. It may also cause constipation. Preparation: Calcium 250 mg Chewable Tablet.8 mg + Copper 1 mg + Boron 250 mgm + Zinc 7. muscles and nerves.36 Hypercalcemia and hyperpara-thyroidism. Preparation: (Calcium 600 mg + Vitamin D 200 I. Hypercalcemia is rarely produced by administration of calcium alone. Hypercalciuria and nephrolithiasis. Vitamin D and Verapamil. Hypersensitivity to any component of this product.5 mg)/Tablet. tetracycline. for the prevention and treatment of osteoporosis. aminocycline or oxytetracycline etc. Vitamin D & Multiminerals Indication: The well balanced formula helps to maintain strong bones and teeth as well as the health of the heart. Concomitant digoxin therapy (requires careful monitoring of serum calcium level). Calcitrol Indication: ® Active Ingredient: Calcitriol. The intestinal uptake of calcium maybe reduced by concomitant ingestion of certain foods (e.U. preferably 1 tablet in the morning and 1 tablet in the evening or as directed by the physician. Hypersensitivity to the component of this preparation. other calcium supplements. but may occur when large doses are given to patients with chronic renal failure. bran. Side Effect: Constipation. Patients with a history of stone formation should also be recommended to increase their fluid intake. renal or cardiac disease. Contraindication and Precaution: Hypercalcemia and hyperparathyroidism. Doxycycline. and other cereal products. • Increases spine density and total body calcium • Significantly increases BMD • Reduces the rate of new vertebral fracture in women with post-menopausal osteoporosis • Restores bone metabolism in patients with predialysis chronic renal failure • For the treatment of hypoparathyroidism and rickets Dosage & Administration: Postmenopausal osteoporosis The recommended dosage for calcitrol is 0. During Calcitrol therapy as soon as the serum calcium level rise to 1 mg/100 ml above normal or serum creatinine rises above 120 micromole/L the dosage of Calcitrol should be substantially reduced or treatment stopped altogether until normocalcemia ensues. 3 and 6 months and at 6 monthly intervals thereafter. Renal osteodystrophy (dialysis patients) The initial daily dose is 0.Product Guide osteoporosis 37 Side Effect: The incidence of adverse Effects reported from clinical use of Calcitriol over a period of 15 years in all indication is very low. Magnesium containing drugs (eg. . Contraindication & Precaution: Calcitrol is contraindicated in patients with known hypersensitivity to any of its ingredients. Calcitrol is also contraindicated in all diseases associated with hypercalcemia. vomiting and constipation. fever with thirst etc. antacids) may cause hypermagnesemia. Mothers may breast feed while taking Calcitrol but serum calcium levels of the mother and infant should be monitored. doses of 0.25 mcg in patients with normal or only slightly reduced serum calcium levels. Concomitant treatment with a thazide diuretc increases the risk of hypercalcemia. Preparation: Calcitrol Licap: Each box containing 30 liquid filled hard gelatin capsules in blister pack. Drug Interaction: Uncontrolled intake of additional calcium containing preparations should be avoided. Hypoparathyroidism and rickets The recommended initial dose of Calcitrol is 0. In patients with renal osteodystrophy or hypoparathyroidism and rickets if within 2-4 weeks no satisfactory response is not observed by usual dose then dose may be increased at two to four week intervals. Serum calcium and creatinine levels should be determined at 4 weeks. C Camlodin® Active Ingredient: Amlodipine. Use in Pregnancy & Lactation:There is no evidence to suggest that vitamin D is teratogenic in humans even at very high doses Calcitrol should be used during pregnancy only if the benefits outweigh the potential risk to the fetus. as hypercalcemia in such patients may precipitate cardiac arrhythmias. The dosage of phosphate binding agents must be adjusted in accordance with the serum phosphate concentration. Indication: Hypertension.25 mcg every other day are sufficient. headache.25 mcg twice daily. Chronic Effects may include dystrophy.25 mcg per day given in the morning. Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis. stable angina. Occasional acute symptoms include anorexia. vasospastic angina. or to Amlodipine.5-10 mg while Benazepril is effective in doses of 10-80 mg. Use in Pregnancy and Lactation: Pregnancy: The combination should be used during pregnancy only if the expected benefit outweighs the potential foetal risk. it is advisable to initiate the therapy with Amlodipine 5 mg + Atenolol 25 mg tablet. Drug withdrawal: Any discontinuation should be gradual and under observation. In elderly patients. Cimetidine. Bronchospasm: The combination should be used with caution in patients with airway obstruction. Overall side Effects include fatigue. Hepatic Camlopril Active Ingredient: Benazepril. Refractory angina pectoris where nitrate therapy has failed. headache. ® Plus Camlodin C Active Ingredient: Atenolol. Ampicillin. drowsiness. ® Amlodipine + Indication: Hypertension. nausea. Warfarin. Dosage and Administration: Initiated with a single dose of Amlodipine 5 mg + Atenolol 50 mg. nausea. oedema. Preparation: (Amlodipine 5 mg + Atenolol 50 mg)/Tablet. Lactation: Nursing mothers should not use the combination. breast feeding should be stopped. Renal Impairment: Caution may be necessary if the creatinine clearance is less than 30ml/min. anxiety and depression. dizziness. Impaired Renal Function: Should be used with caution in patients . fatigue.38 Dosage and Administration: 5-10 mg once daily. edema. erythema multiforme. flushing. Contraindication and Precaution: Hypersensitivity to any of the component. Side Effect: Well tolerated. Dosage and Administration: Amlodipine is an effective treatment of hypertension in once-daily doses of 2. Post MI. to any other ACE inhibitor. Contraindication and Known hypersensitivity. gum hyperplasia. Oral antidiabetic and insulin. (Amlodipine 5 mg + Atenolol 25 mg)/Tablet. If its use is considered necessary. Depending upon the therapeutic response. Contraindication and Precaution: In patients who are hypersensitive to Benazepril. Drug Interaction: Digoxin. Drug Interaction: Disopyramide. Side Effect: Headache. titration of the dosage is recommended. Precaution: Product Guide impairment: Caution may be necessary in the use of the combination in patients with severe liver damage. Preparation: 5 mg and 10 mg Tablet. Use in Pregnancy and Lactation: Not recommended. Amlodipine + Indication: Hypertension not controlled by monotherapy. Patients with angina pectoris & hypertension as co-existing diseases. triamterene. dyspepsia.stomach pain. Primary Dysbetalipoproteinemia. musculoskeletal pain. and muscle cramps. edema. skin nodule. Maximum dose of Amlodipine is 10 mg once daily and Atorvastatin is 80 mg once daily. cramps. Side Effect: In general. muscle and joint pain. Body as a Whole: Asthenia and fatigue. Drug Interaction: Diuretics. 5 mg + C . dizziness. amiloride. nausea. Metabolic and Nutritional: Hypokalemia. and polyuria. Dermatologic: Flushing. hot flashes. tremor. patients with active liver disease because of atorvastatin component which may include unexplained persistent elevations of serum transaminases. Use in Pregnancy and Lactation: Should not be used. CNS: Insomnia. Urogenital: Sexual problems such as impotence.Product Guide with severe renal disease. and decreased libido. constipation. diarrhea. Digestive: Dry mouth.sleepiness. Preparation: (Amlodipine 5 mg + Benazepril HCl 10 mg)/Capsule. Preparation: Amlodipine Atorvastatin 10 mg tablet. Side Effect: Generally mild and transient. and others) or potassium supplements. Some common side effects include headache. caution should be exercised when administering this combination to patients with severe hepatic impairment. 39 Camlotor® Active Ingredient: Amlodipine + Atorvastatin. The most common reasons for discontinuation of therapy with this combination were cough. Nursing Mothers: It is recommended that nursing should be discontinued while this combination is administered. Homozygous Familial Hypercholesterolaemia Dosage & administration: One tablet once daily. Chronic Stable Angina. upset stomach. Elevated Serum TG Levels. and dermatitis. diarrhea. Musculoskeletal: Back pain. tiredness. Use in Pregnancy and Lactation: Pregnancy Categories C (first trimester) and D (second and third trimesters). nervousness. Patients with Congestive Heart Failure: Calcium channel blockers should be used with caution in patients with heart failure. treatment with amlodipine and atorvastatin combination is well tolerated. (Amlodipine 5 mg + Benazepril HCl 20 mg)/Capsule. tendon problems etc.nausea. arrhythmia. Respiratory: Pharyngitis. palpitation. Vasospastic Angina Atorvastatin: Heterozygous Familial and Nonfamilial Hypercholesterolaemia. Contraindication: Hypersensitivity to any component of this medication. flushing. abdominal pain. Lithium. Potassiumsparing diuretics (spironolactone. rash. and esophagitis. Patients with Hepatic Failure: In patients with impaired hepatic function. anxiety. Indication: Amlodipine: Hypertension. Maximum dose: Amlodipine 10 mg and Valsartan 320 mg.000 to 600. Indication: For the symptomatic relief of pain associated with osteoarthritis and Candex® Active Ingredient: Nystatin. C Side Effect: Oral irritation or sensitization. Rash. caution should be exercised when Nystatin is prescribed for nursing woman. May be administered with other antihypertensive agents. sore throat and discomfort when swallowing. orally. dizziness etc. Children And Adults: 4-6 mL (400. Note: Limited clinical studies in premature and low birth weight infants indicate that 1 mL four times daily is Effective. with or without food. upper respiratory tract infection. Amlodipine + Dosage & Administration: Infants: 2 mL (200.The preparation should be retained in the mouth as long as possible before swallowing.000 units) four times daily (one-half of dose in each side of mouth).( Amlodipine 5 mg + Valsartan 160 mg)/ Tablet. & Precaution: Active Ingredient: Valsartan. nasal congestion. including urticaria has been reported rarely. use dropper to place one-half of dose in each side of mouth and avoid feeding for 5 to 10 minutes). nausea and vomiting. In elderly patients. avoid fetal or neonatal exposure. Use in Pregnancy and Lactation: Nystatin should be prescribed during pregnancy only if the potential benefits to be derived outweigh the possible risks involved. nausea. Side Effect: The most common side effects include peripheral edema. diarrhoea. once daily.40 Product Guide TM Camoval Indication: Candidiasis. Preparation: 1 lac unit/1 ml Suspension.5 mg of Amlodipine. Dosage & Administration: Once daily. Continue treatment for at least 48 hours after perioral symptoms have disappeared and cultures demonstrate eradication of Candida albicans. Use in Pregnancy & Lactation: Not recommended. Use in Children: Safety and effectiveness is not established. Indication: Hypertension. titrate slowly in patients with impaired hepatic or severely impaired renal function. warn patients with severe obstructive coronary artery disease about the risk of myocardial infarction or increased angina. Preparation: (Amlodipine 5 mg + Valsartan 80 mg)/ Tablet. therapy should be initiated at 2. Drug Interaction: Not known. 000 units) four times daily (in infants and young children. Contraindication Hypersensitivity. Capsi® Active Ingredient: Capsaicin. . gastrointestinal distress. Contraindication & Precaution: Hypersensitivity to any component of the product. assess for hypotension. Preparation: 5 mg Tablet.15 mg/ day which may be taken as a single daily dose. Pregnancy and Lactation:Recommended but the smallest effective dose should be used least overdosage adversely affects the foetus. paraesthesias. Use in Children: Recommended Drug Interaction : Iodine or iodine excess may decrease the response to Carbimazole. rash. pruritis. but may persist particularly when application schedules of less than 4 times daily are used. It can also be used in combination with radio-active ablative therapy. urticaria. Dosage & Administration: Adults: For topical administration to unbroken skin. Daily dosage should be divided. skin pigmentation. Use in Pregnancy & Lactation: The safety of Capsaicin during pregnancy and lactation has not been established. in either humans or animals. Contraindication & Precaution: Capsaicin cream is contraindicated on broken or irritated skin. C Carbizol® Active Ingredient: Carbimazole. Pain relief usually begins within the first week of treatment and increases with continuing regular application for the next two to eight weeks. The cream should be gently rubbed in. Hands should be washed immediately after application of Capsaicin unless hands and fingers are being treated. Side Effect: Capsaicin cream may cause transient burning following application. headache. Maintenance regimen: Dose is gradually reduced to maintain a euthyroid state. This burning sensation generally disappears after several days of treatment. Preparation: Capsaicin 0. Side Effect: Rarely seen. Not suitable for use in children.Final dosage is usually in the range of 5 . in the small amounts absorbed transdermally from Capsaicin cream. 41 roidism.60 mg. Apply only a small amount of Capsi cream (pea size) to affected area four times daily. it is considered unlikely that Capsaicin will cause any adverse Effects in humans. However. and gastro-intestinal disturbances. there should be no residue left on the surface. Neonates & Children below 12 years: The usual initial dose is 250 mcg /Kg/day in divided doses.025% Cream. Indications: Management of hyperthy- . Duration of treatment: 18 to 24 months Contraindication & Precaution: Patients with known hypersensitivity to Carbimazole or other thiourea antithyroid agents. Dosage & Administration: Adults: The initial dose: 20 . and also for the preparation of patients for thyroidectomy. thyrotoxicosis (including thyroid storm). It is also contraindicated in patients with known hypersensitivity to capsaicin or any of the excipients used in this product. in 2-3 divided doses until the patient is euthyroid.Product Guide rheumatoid arthritis. arthralgia. insomnia. Preparation: (Atenolol 50 Chlorthalidone 25 mg)/Tablet. Clonidine. fatigue. mg + Cardipro® Active Ingredient: Atenolol. Dosage and Administration: Cardipro 50 mg once daily. hypochloremic alkalosis. the dosage should be increased to one Chlorthalidone 25 mg + Atenolol 100 mg tablet once a day. Cardiogenic shock. Use in Pregnancy and Lactation: Pregnancy Category D. Cardipro® Plus Active Ingredient: Chlorthalidone. The adverse Effects observed for this combination are essentially the same as those seen with the individual components. Caution should be exercised when this combination is administered to a woman who is breastfeeding. This combination may aggravate peripheral arterial circulatory disorders. If an optimal response is not achieved. Use in Pediatric Patients: Safety and Effectiveness in pediatric patients have not been established. Indication: Antithrombotic action. cardiogenic shock. Class 1 anti-arrhythmic drug (e. impotence and paraesthesia. Carva® Active Ingredient: Aspirin. disopyramide). can be raised to 100-200 mg. heart block greater than first degree. hypersensitivity to this product or to sulfonamidederived drugs. Drug Interaction: Other antihypertensive agents. Patients should be observed for clinical signs of fluid or electrolyte imbalance. myocardial infarction. ie. Side Effect: Cold extremities. Side Effect: Most adverse Effects have been mild and transient. diarrhoea. Atenolol + Indication: Treatment of hypertension. Use in Pregnancy and Lactation: Recommended. overt cardiac failure anuria. Indication: Hypertension. reserpine). Indomethacin. vivid dreams.42 Product Guide Contraindication and Precaution: Sinus bradycardia. Catecholamine depletor (e. C Drug Interaction: Verapamil. Contraindication and Precaution: Second and third degree heart block. cardiac arrhythmia. Untreated heart failure.g. constipation. and hypokalemia. Dosage and Administration: Initial dose should be one Chlorthalidone 25 mg + Atenolol 50 mg (Cardipro 50 Plus) tablet once a day. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. angina pectoris. Preparation: 50 mg and 100 mg Tablet.g. mediated through inhibition of platelet . hyponatremia. Product Guide 43 activation, secondary prophylaxis following myocardial infarction and unstable angina or cerebral transient ischemic attacks. Dosage and Administration: 150 mg at diagnosis and 75 mg daily thereafter. Contraindication: Hypersensitivity to aspirin, hypoprothrombinaemia, haemophilia and peptic ulceration, asthma. Side Effect: Hypersensitivity, asthma, urate kidney stones, chronic gastro-intestinal blood loss, tinnitus, nausea and vomiting. Drug Interaction: Oral anticoagulants, oral hypoglycemic, phenytoin, probenecid, sulphonamides. Use in Pregnancy and Lactation: Aspirin should be avoided during the last 3 months of pregnancy. It should not be used by patients who are breast feeding. Preparation: 75 mg Tablet. Cavir TM Active Ingredient: Entecavir 0.5 mg & 1 mg Tablet. Indication: Chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum Aminotransferase (ALT or AST) or histologically active disease. Dosage & Administration: Cavir should be administered on an empty stomach (at least 2 hours after a meal or 2 hours before the next meal). Nucleoside-treatment-naive (16 years): 0.5 mg once daily. Lamivudine-refractory or known Lamivudine or Telbivudine resistance mutations (16 years): 1 mg once daily. Decompensated Liver Disease: Recommended dose is 1 mg once daily. Renal Impairment: Dosage adjustment is recommended for patients with creatinine clearance less than 50 ml/min, including patients on hemodialysis or Continuous Ambulatory Peritoneal Dialysis (CAPD), as shown belowDosage of Entecavir in patients with renal impairment: Dosage of Entecavir in patients with renal impairment Creatinine ≥50 clearance ( ml/min) Dose 30 to <50 10 to <30 <10, Hemodialysis or CAPD C 0.5 mg every 0.5 mg every 0.5 mg every 0.5 mg every 7 days 24 hrs 48 hrs 72 hrs 44 Contraindication & Precaution: Entecavir is contraindicated in patients with known hypersensitivity to Entecavir or any component of the product. Lactic acidosis: Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases have been reported with the use of nucleoside analogues alone or in combination with antiretrovirals. Exacerbations of hepatitis B after discontinuation of treatment: severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapy, including Entecavir. Side Effect: The most common side effects are headache, fatigue, dizziness and nausea. Drug Interaction: Coadministration of Entecavir with drugs that reduce renal function or compete for active tubular secretion may increase serum concentration of either Entecavir or the coadministered drug. Coadministration of Entecavir with Lamivudine, Adefovir Dipivoxil, or Tenofovir Disoproxil Fumatare did not result significant drug interactions. Use in Pregnancy & Lactation: Pregnancy: USFDA pregnancy category C. There are no data on the Effect of Entecavir on transmission of HBV from mother to infant. Therefore, appropriate care should be taken. Lactation:It is not known whether entecavir is excreted in human milk. Mothers should be instructed not to breast feed if they are taking Entecavir Product Guide Use in Children: Safety and Effectiveness of Entecavir in pediatric patients below the age of 16 years have not been established. Preparation: 0.5 mg & 1 mg Tablet. Ceevit® Active Ingredient: Ascorbic acid and Sodium Ascorbate. Indication: Scurvy, pregnancy, lactation, infection, trauma, burns, cold exposure, following surgery, fever, stress, peptic ulcer, cancer, methaemoglobinaemia haematuria, dental caries, pyorrhea, acne, infertility, atherosclerosis, fractures, leg ulcers, hay fever, vascular thrombosis prevention, levodopa toxicity, succinylcholine toxicity, arsenic toxicity etc. Dosage & Administration: 1-2 tablets daily. Contraindication & Precaution: There is no serious contraindication to the administration of Vitamin C. Side Effect: Diarrhoea, hyperoxaluria may occur. Drug Interaction: Ascorbic acid increases the apparent half-life of paracetamol & enhances iron absorption from the gastro intestinal tract. Use in Pregnancy and Lactation: The drug is safe in normal doses in pregnant women, but a daily intake of 5 gm or more is reported to have caused abortion. The drug may be taken safely during lactation. C Product Guide Preparation: 250 mg Tablets. 45 pregnancy and lactation usual dose is safe. Preparation: Vitamin Effervescent Tablet. C 1000 mg Ceevit® Forte Active Ingredient: Vitamin C (Ascorbic acid). Indication: Treatment or prevention of Vitamin C Deficiency, Scurvy, Infection, Trauma, Burns, Cold exposure, Following Surgery, Fever, Stress, Cancer, Methaemoglobinaemia and Children receiving unfortified formulas. Also indicated in Hematuria, Dental Caries, Gum Diseases, Pyorrhea, Acne, Infertility, Atherosclerosis, Fractures, Leg ulcers, Hay fever, Vascular thrombosis prevention, Levodopa toxicity, Arsenic toxicity and etc. Dosage & Administration: One tablet daily with a meal or as directed by physician. Dissolve one tablet in half glass (100 ml) of water and drink instantly. Contraindication & Precaution: There is no serious contraindication to the administration of Vitamin C. Diabetes, patients prone to recurrent renal calculi and those on sodium restricted diets or anticoagulant therapy should not take excessive doses of ascorbic acid over an extended period of time. Side Effect: Generally ascorbic acid is well tolerated. However, few side Effects including stomach upset, diarrhea, mouth sores or frequent urination may be seen. Drug Interaction: Limited evidence suggests that ascorbic acid may influence the intensity and duration of action of byhydroxycoumarin. Use in Pregnancy and Lactation: During Cef-3 TM Active Ingredient: Cefixime. Indication: Urinary tract infections, upper and lower respiratory tract infections, acute otitis media, gonococcal urethritis and enteric fever. Dosage & Administration: 200-400 mg as a single dose or in 2 divided doses daily for 7-14 days, Child dose : 8 mg/kg daily as a single dose or in two divided doses for 7-14 days. Contraindication & Precaution: Known hypersensitivity to Cephalosporin group of drugs. Side Effect: Diarrhoea, nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache and dizziness. Use in Pregnancy and Lactation: Cefixime should not be used in pregnancy or in nursing mothers unless considered essential by the physician. Preparation: 200 mg Capsule, 200 mg Tablet, 400 mg Capsule, 400 mg Tablet 100 mg/5 ml Suspension (30 ml, 40 ml & 50 ml), 200 mg/5ml Suspension. C Cefotil TM Active Ingredient: Cefuroxime. 46 Indication: 1. Upper respiratory tract infections, for example, ear, nose and throat infections such as otitis media, sinusitis, tonsillitis and pharyngitis. 2. Lower respiratory tract infections: for example, acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia. 3. Skin and soft tissue infections: such as furunculosis, pyoderma, and impetigo. 4. Genito-urinary tract infections: such as pyelonephritis, urethritis, and cystitis. 5. Gonorrhoea: acute uncomplicated gonococcal urethritis, and cervicitis. 6. Early Lyme disease & subsequent prevention of late Lyme disease. Dosage and administration: Adults : 250 mg b. i.d. upto 500 mg b. i. d. should be given. For urinary tract infections a dose of 125 mg b.i.d is usually adequate. A single dose of one gram is recommended for the treatment of uncomplicated gonorrhoea. Children : The usual dose is 125 mg b. i. d., or 10 mg/kg b. i. d. to a maximum of 250 mg daily. The usual course of therapy is 7-10 days. Cefuroxime should be taken after food for optimum absorption. Parenteral Dosage : Adults : 750 mg to 1.5 g IM or IV every 8 hourly, usually 5 to 10 days. Infants and children (>3 months) : 50 to 100 mg/ kg/day in equally divided doses every 6 to 8 hours. Contraindication and Precaution: Known allergy to Cephalosporins. As with other antibiotics, prolonged use of Cefuroxime may result in the over growth of non-susceptible organisms (e.g. Candida, Enterococci, Clostridium difficile), which may require interruption of treatment. Pseudomonas colitis has been reported with the use of broad-spectrum antibiotics, therefore, it is important to consider its diagnosis in patients who develop serious diarrhoea during or after antibiotic use. Product Guide Side Effect: Nausea and vomiting. Use in Pregnancy and Lactation: While all antibiotics should be avoided in the first trimester if possible. Cefuroxime has been safely used in later pregnancy to treat urinary and other infections. Caution should be exercised when Cefuroxime is administered to a nursing mother. Preparation: 125 mg, 250 mg & 500 mg Tablet, 125 mg/5 ml Suspension, 750 mg IM/IV Injection, 1.5 gm IV injection. Ceftron® Active Ingredient: Ceftriaxone. Indication: Renal and urinary tract infections, Lower respiratory tract infections, particularly pneumonia, Gonococcal infections, Skin and soft tissue, bone and joint infections, Bacterial meningitis, Serious bacterial infections e.g. septicemia, ENT infections, Infections in cancer patients, Prevention of postoperative infection, Perioperative prophylaxis of infections associated with surgery, Typhoid fever. Dosage and Administration: Adults and children (12 years & over): 1 gm once daily. In severe infections : 2-4 gm daily, normally as a single dose every 24 hours. Children (under 12 years) : 20-50 mg/kg/day. In severe infection: up to 80 mg/kg/day may be given. Contraindication & Precaution: Hypersensitivity to Cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. Its safety in human pregnancy has not been established. Therefore it should not be used in pregnancy unless C Product Guide absolutely indicated. Mothers receiving Ceftriaxone should not breast-feed. In severe renal impairment accompanied by hepatic insufficiency, dosage reduction is required. Side Effect: Ceftriaxone is generally well tolerated. A few side-Effects such as diarrhea, nausea and vomiting, stomatitis and glossitis, rash, pruritus, urticaria, edema & erythema multiforme, eosinophilia, thrombocytopenia, leukopenia, and neutropenia, elevations of SGOT or SGPT, bilirubinemia, headache, hyperactivity, nervousness,sleep disturbances,confusion, hypertonia and dizziness. Drug Interaction: A possible disulfiramlike reaction may occur with alcohol. Preparation: 250 mg IV, 250 mg IM, 500 mg IV, 500 mg IM, 1 gm IV, 1 gm IM and 2 gm IV Injection. 47 of menopausal syndrome etc. Ophthalmology: Vascular disorder of the choroid and retina due to arteriosclerosis. Vasospasm, macula degenerations, arterial or venous thrombosis or embolism or glaucoma secondary to above mentioned disorders. Otology: For the treatment of impaired hearing of vascular toxic (iatrogenic) origin presbyacusis. Meniere’s disease, cochleovestibular neuritis, tinnitus and dizziness of labyrinth origin. Dosage & Administration: 1-2 tablets thrice daily, the maintenance dose is one tablet thrice daily. Contraindication & Precaution: Don’t use in pregnancy. In the acute case of above mentioned neurological, ophthalmological and otological disorders until the improvement of symptoms, parenteral treatment is recommended followed by oral treatment. In chronic cases oral therapy should be applied. Interactions of the tablet have not been reported so far therefore, it can be applied in combinations. Side Effect: Transient tachycardia may occur. hypotension, C Cerevas® Active Ingredient: Vinpocetine. Indications: Acute Cerebro-Vascular Accidents (Strokes): Ischemic strokes due to cerebral thrombosis, cerebral embolism, acute circulatory disorder, hypertensive crisis; the acute cardiovascular disorders, ischemic neurological deficit (RIND), complete stroke (CS), multiinfarete dementia, cerebral arteriosclerosis, hypertensive encephalopathy, postapoplectic conditions with the background of hemorrhagic strokes etc. Geriatrics: For relief of psychosomatic symptoms in the elderly due to cerebral insufficiency e.g. forgetfulness, memory disturbances, slow thinking, lack of concentration, dizziness, mood instability, aphasia, sleep disturbances, vasovegetative symptoms Use in Children: Recommended Preparation: 5 mg tablet. Cilosta® Active Ingredient: Cilostazol. Indication: Cilosta is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Indication: Cerebral circulatory disorders: a. etc. trophic disturbances. Postapoplectic disorders d. Side Effect: Somnolence gastrointestinal disturbances. vomiting. Migraine 2. 3. Because of the potential risk to nursing infants. The less frequent side Effects are anorexia and oedema. Lactation: Transfer of Cilostazol into milk has been reported in experimental animals. There is no information with respect to the efficacy or safety of the concurrent use of Cilostazol and Clopidogrel. Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis. Contraindication & Precaution: Cilostazol is contraindicated in patients with congestive heart failure of any severity. diarrhoea. Cinnarizine + Indication: Vertigo & Peripheral arterial disorders.48 Dosage and Administration: The recommended dosage of Cilosta is 100 mg bid. diabetes. rash etc. Population pharmacokinetic studies showed higher concentrations of Cilostazol among patients concurrently treated with Diltiazem. and Diltiazem. Side Effect: The most common side Effects are headache. Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis. b. Sequelae of cerebral and cranial trauma. Itraconazole. Drug Interactions: Omeprazole and Erythromycin significantly increased the systemic exposure of Cilostazol and/ or its major metabolites. acrocyanosis pernio. Disorders of balance. Use in Pregnancy and Lactation: Pregnancy:There are no adequate and well controlled studies in pregnant women. Cilostazol is also contraindicated in patients with known or suspected hypersensitivity to any of its components. leg cramps. it is not advisable to administer Cinnarizine in pregnancy. thromboangiitis. pregangrene. and C Use in Pregnancy and Lactation: The safety of Cinnarizine in human pregnancy has not been established although studies in animals have not demonstrated teratogenic Effects. A dose of 50 mg bid should be considered during coadministration of Ketoconazole.) such as intermittent claudication. taken at least half an hour before or two hours after breakfast and dinner. trophic and varicose ulcers. c. Dosage & Administration: Cinaron 15 to 30 mg three times daily. . Therefore. Cinaron® Plus Active Ingredient: Dimenhydrinate. Erythromycin. a decision should be made to discontinue nursing or to discontinue Cilostazol. Product Guide Cinaron® Active Ingredient: Cinnarizine. Preparation: 15 mg Tablet. cold extremities. Raynaud’s disease. paresthesia. nocturnal cramps. Preparation: 100 mg Tablet. staphylococcus and streptococci. or XR 1 gm once daily 7 to 14 Days. Use inPregnancy & Lactation: Risk benefit ratio is considered. Dosage & Administration: Eye: The recommended dosage regimen for the treatment of corneal ulcers is two drops into the affected eye every 15 minutes for . 750 mg & XR 1 gm Tablet & 250 mg Powder for Suspension. Indication: Urinary tract infections. Contraindication & Precaution: Not known.i. or XR 1 gm once daily 10 Days.i. Preparation: Tablet. Ciprocin750 is also indicated in surgical prophylaxis. Mild/Moderate and Severe/Complicated-500 mg b.i. dizziness. Ciprocin TM Active Ingredient: Ciprofloxacin. Somnolence & GI 49 Severe 500 mg b. (maximum 750 mg per dose) for 10 to 21 days. Precaution and Warning: It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion.d.d 7 to 14 Days.I. or XR 1 gm once daily 5 to 7 Days. Use in Children: Not established. Use in Pregnancy and Lactation:The safety and Effectiveness of ciprofloxacin in pregnant and lactating women have not been established. Side Effect: disturbance. 3 Days. Ear: Otitis externa. headache.d. acute otitis media. bacterial Conjunctivitis. crush. skin rashes.i. Use in Children: From 1 years and above.i.d. skin and soft tissue infections. Indication: Eye: Corneal ulcer. bone and joint infections.i. Severe/Complicated 750 mg twice daily 7 to 14 Days. Pediatric Dosage: 10 mg/kg to 20 mg/kg b. severe infections particularly due to pseudomonas. Typhoid Fever : Mild/Moderate 500 mg b.i.i. or XR 1 gm once daily 10 Days. lower respiratory tract infections. Ciprocin 750 tablet is specially indicated for the treatment of pseudomonal infections of lower respiratory tract. Do not split. chronic suppurative otitis media. Infectious Diarrhea : Mild/Moderate/ C Ciprocin® Eye/Ear Drops Active Ingredient: Ciprofloxacin. Drug Interaction: Not known. Dosage and Administration: Urinary Tract Infection : Acute Uncomplicated-100 mg or 250 mg b.Product Guide Dosage & Administration: 1 tab thrice daily. G.d. or chew the tablet. Adverse Reaction: Nausea and other gastrointestinal disturbances. Crystalluria. 500 mg. Lower Respiratory Tract Infection : Mild/Moderate 500 mg b. uncomplicated gonorrhoea.d. Ciprocin® XR 1 gm should be swallowed whole.d. Preparation: Ciprocin 250 mg.d. Acute Sinusitis : Mild/Moderate 500 mg b. Contraindication: Patients with a history of hypersensitivity to Ciprofloxacin or to other quinolones. Severe/Complicated 750 mg b. tract infections. 7 to 14 Days or XR 1 gm once daily for 7 to 14 days. foreign body sensation. place two drops in the affected eye every four hours. Contraindication & Precaution: Hypersensitivity. Side Effect: Local burning or discomfort.3 drops every 2 . On the third to fourteenth day. Preparation: 0. 2 . itching. crystals/scales. Treatment may be continued after 14 days if corneal re-epithelization has not been occurred. Drug Interaction: Specific drug interaction studies have not been conducted with ophthalmic Ciprofloxacin. Ear : For all infections. Use in Pregnancy and Lactation: Ciprofloxacin ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Indication: Ciprocin IV is indicated for the treatment of following infections caused by sensitive bacteria- • Urinary Tract Infection • Lower Respiratory Tract Infection • Nosocomial Pneumonia • Skin and Skin Structure Infection • Bone and Joint Infection • Complicated Intra-Abdominal Infection • Acute Sinusitis • Chronic Bacterial Prostatitis • Infectious diarrhea • Inhalational Anthrax Indication Urinary Tract Infection Lower Infection Severity Mild to Moderate Severe or Complicated Respiratory Mild to Moderate Severe or Complicated Dose 200 mg 400 mg 400 mg 400 mg Frequency Days q12h q12h q12h q8h 7-14 days 7-14 days 7-14 days 7-14 days . crusting.50 Product Guide the first 6 hours and then two drops into the affected eye every 30 minutes for the remainder of the first day. On the second day.3% Eye/Ear Drops. conjunctival hyperemia and a bad taste. instill 2 drops in the affected eye hourly.3 hours initially. C Ciprocin® 200 IV Active Ingredient: Ciprofloxacin. overgrowth of non-susceptible organisms. the dosage should be 5-10 mg/kg/day in two divided doses. restlessness. headache.6 weeks ≥ 4 . Preparation: Ciprocin 200 IV: Each box contains 1 bag of 100 ml solution for intravenous infusion. Ciprofloxacin is excreted in human milk. if the benefited of ciprofloxacin therapy are considered to overweight the potential risk. and rash. . C Climycin TM Active Ingredient: Clindamycin.A b d o m i n a l Complicated Infection Acute Sinusitis Chronic Prostatitis Mild to Moderate Bacterial Mild to Moderate 400 mg 400 mg 400 mg 400 mg 400 mg 400 mg 400 mg q8h q12h q8h q12h q8h q12h q12h q12h 51 7-10 days 7-14 day 7-14 day ≥ 4 . any member of the quinolone class of antimicrobial agents.V. Use in Children: Ciprofloxacin is usually not recommended for use in children. local I. central nervous system disturbance.6 weeks 7-14 day 10 days 18 days Contraindication & Precaution: Ciprofloxacin is contraindicated in persons with a history of hypersensitivity to ciprofloxacin. Use in Pregnancy & Lactation: The safety and Effectiveness of Ciprofloxacin in pregnant and lactating women have not been established.Product Guide Nosocomial Pneumonia Mild or Moderate or 400 mg Severe Skin and Skin Structure Mild to Moderate Infection Severe or Complicated Bone and Joint Infection Mild to Moderate Severe or Complicated I n t r a . liver function tests abnormal. This may result in increased risk of theophylline-related adverse reactions. However. Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in the serum. diarrhea. site reactions. Side Effect: Nausea. Drug Interaction: Concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life. Concomitant administration with tizanidine is contraindicated. eosinphilia. depending on the severity of the infections. burn and other infections. sinusitis and diarrhea are the common side effects. • Do not wash your face more than 2 or 3 times a day. Product Guide Use in Children: When Clindamycin is administered to newborns and infants (birth to 16 years) appropriate monitoring of organ system functions is desirable. More severe infections: 16 . Side Effect: Erythema. Use in Pregnancy & Lactation: Pregnancy: Pregnancy Category B: Clindamycin should be used in pregnancy only if clearly needed. Skin and soft tissue infections. vomiting and diarrhoea. As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multidrug resistant Plasmodium falciporum infection Dosage & Administration: Adults: Serious Infections: 150 mg .20 mg/kg/day divided into three or four equal doses. After the application of the Gel. Pediatric Patients: Serious Infections: 8 . nose. keep away from sunlight. Exercise special caution while applying clindamycin or C . Side-Effect: The adverse Effects have been reported with the use of clindamycin are abdominal pain. Clinface® Gel Active Ingredient:Clindamycin Phosphate & Tretinoin. then pat the skin dry. Septicemia and endocarditis. Contraindication & Precaution: Clindamycin is contraindicated in patients previously found to be sensitive to Clindamycin or lincomycin or any of the ingredients of this medicine. Indication: Clinface Gel is indicated for the topical treatment of Acne vulgaris. Contraindication & Precaution: Clinface® Gel should not be administered to individuals who are hypersensitive to clindamycin or tretinoin or any other component of the Gel.16 mg/kg/day divided into three or four equal doses. staphylococci and pneumococci: Upper respiratory tract infections. Lactation : Clindamycin has been reported to appear in breast milk. • Apply the Gel with finger tips through the face gently.300 mg every six hours.52 Indication: Climycin has been shown to be Effective in the treatment of the following infections when caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as streptococci. it is not recommended for nursing mothers if not clearly needed. Apply the sunscreen cream as needed. nasopharyngitis. cut. Bone and joint infections. More severe infections: 300 mg 450 mg every six hours. lips. Intra-abdominal infections. Lower respiratory tract infections. Clinface® Gel should not be applied to eyes. dry skin. In the morning • Apply a sunscreen after the application of Gel. urticaria. oesophagitis and oesophagial ulcer. Preparation: 150 mg & 300 mg Capsule. skin rashes. Dosage & Administration: Before sleep • Wash the face gently with a mild soap and water. pruritus. ear. Dental infections. scaling. Therefore. nausea. cough. Pelvic infections. Use in Pregnancy & Lactation: It is not known whether clindamycin or tretinoin is excreted in human milk. bursitis. twice) daily by intramuscular injection. Emulgel and Gel : Should be rubbed gently into the skin. daily in divided doses. Depending on the size of the affected site to be treated 2-4 gm gel should be applied 3 . A further ampoule may be administered after 30 minutes. Ankylosing spondylitis. Contraindication & Precaution: Hypersensitivity to benzodiazepines. Acute gout. 50 mg or 100 mg suppository only: 75-150 mg daily. fatigue.Renal colic : One ampoule once daily intramuscularly. Indication: Arthritic conditions: Rheumatoid Arthritis.5 mg or 25 mg suppository only: 1-3 mg/kg daily. vertigo and these may diminish with continued therapy. tension. depressive mood. Side Effect: Drowsiness. Suppository: Should be administered rectally. 1-3 mg of diclofenac/kg body wt. Indication: Clobam relieves anxiety. The concurrent administration of hypnotic or antidepressants with sedative activity may cause an increase in side effects.150 mg daily in 2 to 3 divided doses. particularly tiredness or drowsiness. Osteoarthritis. Preparation: 10 mg Tablet. tenosynovitis. Children: Over 3 years up to 1/2 of the adult dose. strains. restlessness. or for those patients in whom Clobam® Active Ingredient: Clobazam. confusion. acute pulmonary insufficiency and in irreversible bronchial obstruction. preferably after food. dislocations. hepatic or renal disease. 53 Clofenac® Active Ingredient: Diclofenac. epilepsy and response in the treatment of fear. including fracture.g. Drug Interaction: The administration of alcohol results in significantly higher serum concentrations of clobazam. tendinitis. Children (1-12 years): 12. Contraindication & Precaution: Diclofenac is contraindicated for those patients who are hypersensitive to diclofenac. Dosage and Administration : 25 mg and 50 mg : Adults: 75 . Children : In juvenile chronic arthritis.if necessary. C . orthopaedic.. hypersensitivity reactions and respiratory depression may occur. irritability. the lowest Effective dosage is recommended. sprains. in divided doses. Dosage & Administration: Adults: 20-30 mg daily in divided dosage or as a single dosage at bed time. respiratory depression. other painful conditions resulting from trauma. Preparation: 15 gm Gel. Injection/Plus injection: Adults : One ampoule once (or in severe cases.Product Guide tretinoin to a nursing mother.4 times daily and rubbed in lightly. dental and other minor surgery. in divided doses.The recommended maximum daily dose of diclofenac is 150 mg. Adults: 25 mg. Elderly patients: In elderly or debilitated patients. sleep disturbances. In patients with active or suspected peptic ulcer or gastrointestinal bleeding. headache. frozen shoulder). ataxia. Occasionally dry mouth. low back pain. acute musculoskeletal disorders such as periarthritis (e. C Clotinex TM Active Ingredient: Enoxaparin.8 days Should be administered concurrently with oral aspirin (100 to 325 mg once daily). vomiting. flatulence. abdominal cramps. 12. administered concurrently with aspirin Subcutaneously 100 anti-Xa IU/kg twice daily for 2 . nausea.. 50 mg DT (Dispersible Tablet). Rare: gastro-intestinal bleeding. peptic ulcer (with or without bleeding or perforation). anorexia. non-specific haemorrhagic colitis and exacerbations of ulcerative colitis or Crohn’s proctocolitis).g. 100 mg TR capsule.54 Product Guide attacks of asthma. myocardial infarction. diuretics. diclofenac is also contraindicated. • Prophylaxis of venous thromboembolic disease. Treatment with enoxaparin sodium in these patients should be prescribed for a minimum of 2 days and continued until clinical stabilization. glossitis. bloody diarrhoea. Dosage & Administration: Indications Recommended Dosage Schedule Treatment of deep vein Subcutaneously 100 anti-Xa IU/kg twice daily for 10 days thrombosis. Treatment of unstable angina and non-Q-wave myocardial infarction. Preparation: 25 mg. quinolone antimicrobials. with or without or Subcutaneously 150 anti-Xa IU/kg once daily for 10 days pulmonary embolism Oral anticoagulant therapy should be initiated when appropriate and enoxaparin sodium treatment should be continued until a therapeutic anticoagulant effect has been achieved. dyspepsia. (Diclofenac Sodium 75 mg + Lidocaine HCl 20 mg)/2 ml injection . etc. methotrexate. Use in Pregnancy and Lactation: Diclofenac tablets and injection should not be prescribed during pregnancy. antidiabetic agents. • Unstable angina. Diclofenac Sodium 75 mg/3 ml injection. Side Effect: Epigastric pain. . In isolated cases: lower gut disorders (e. Drug Interaction: Lithium and digoxin. cyclosporin. 1% Emulgel & Gel. 50 mg tablet. diarrhoea. 50 mg & 100 mg Suppository. very small quantities may be detected in breast milk but no undesirable Effects on the infant are to be expected.5 mg. urticaria or acute rhinitis are precipitated by aspirin or other NSAIDs possessing prostaglandin synthetase inhibiting activity. constipation. Indication: • Treatment of deep vein thrombosis. 25 mg. anticoagulants.100 mg SR tablet. pancreatitis. Precaution: Enoxaparin Sodium should be injected by deep subcutaneous route in prophylactic and curative treatment and by intravascular route during hemodialysis. Enoxaparin Sodium should be used with caution in conditions with increased potential for bleeding.4 ml) once daily for 6 . following dosage adjustments are recommended: Prophylactic dose ranges: 2000 antiXa IU once daily. For patients with severe (creatinine clearance <30 ml/min) renal impairment. Prophylaxis of venous Subcutaneously 4000 anti-Xa IU (0. Patients with active major bleeding and conditions with a high risk of uncontrolled hemorrhage including recent hemorrhagic stroke. enoxaparin sodium should be introduced into the arterial line of the circuit at the beginning of the dialysis session.14 thromboembolic disease days in medical patients Dose in Elderly patients: No dosage adjustment is necessary.4 ml) once daily for 7 to 10 days.2 ml) or 4000 anti-Xa IU (0. For patients with a high risk of hemorrhage.g.Product Guide Prevention of thrombus formation in extra corporeal circulation during hemodialysis 55 Recommended dose is 100 anti-Xa IU/kg. Dose in Hepatic Impairment: Caution should be used in hepatically impaired patients. abdominal surgery): in surgical patients Subcutaneously 2000 anti-Xa IU (0. Contraindication & Precaution: Contraindication: Patients with known hypersensitivity to Enoxaparin Sodium. The first injection should be given 2 hours before the surgical procedure. Longer treatment duration may be appropriate in some patients like continued therapy with 4000 anti-Xa IU once daily for 3 weeks following the initial therapy has been proven to be beneficial in orthopaedic surgery. the dose should be reduced to 50 anti-Xa IU/kg for double vascular access or 75 anti-Xa IU/kg for single vascular access. Do not administer by the intramuscular route. unless kidney function is impaired. Patients undergoing orthopedic surgery with a high risk of thromboembolism: Subcutaneously 4000 anti-Xa IU (0. heparin or other low molecular weight heparins. The first injection should be given 2 hours before the surgical procedure. Dose in Renal Impairment: No dosage adjustment is recommended in patients with moderate and mild renal impairment. During hemodialysis.4 ml) once daily for 7 to 10 days. Prophylaxis of venous Patients undergoing general surgery with a moderate risk of thromboembolic disease thromboembolism (e. Therapeutic dose ranges: 100 anti-Xa IU/kg once daily. It is recommended that the platelet counts be measured before the initiation of the C . ticlopidine. tricyclic antidepressants and other drugs having anticholinergic activity. antihistamines. Diarrhoea. cases of neuraxial hematomas with concurrent use of enoxaparin and spinal/ epidural anesthesia or spinal puncture have resulted in varying degrees of neurological injuries.6 ml) pre-filled syringe injection. Patients with hypersensitivity to dicycloverine hydrochloride. MAO inhibitors. Indication: Management of type 2 . headache. urinary hesitancy. Maximum recommended oral dose is 160 mg daily in divided dose. Side Effect: Insomnia. Obstruction disorder in GIT. palpitations etc. Diverticulitis. Dicycloverine should be used during pregnancy only if clearly needed.5 to 10 mg three times a day. Dicycloverine should not be used in case of lactating mother. Children : Children over 6 months of age. Use in Children: Safety and Effectiveness have not been established. These agents include medications such as: acetylsalicylic acid (and derivatives). Drug Interaction: Agents which affect hemostasis should be discontinued prior to Enoxaparin Sodium therapy unless strictly indicated. Severe ulcerative colitis. Myasthenia gravis. Use in Pregnancy and Lactation: Pregnancy Category B. C Colicon TM Active Ingredient: Dicycloverine HCl. nitrates and nitrites. weakness. 20 mg/2 ml Injection. skin rash at injection site. other anti platelet aggregation agents including glycoprotein IIb/IIIa antagonists. pain. Contraindication and Precaution: Obstructive uropathy. Preparation: 40 mg (4000 anti-Xa IU/0. glucocorticoids. GIT spasm. elevations of serum amino transferase. NSAIDs (including ketorolac).4 ml) pre-filled syringe injection. dextran 40. IM injection : Usual recommended injectable dose is 80 mg daily by IM route in 4 divided dose. 10 mg/5 ml Syrup (50 ml).56 treatment and regularly thereafter during treatment. Dysentery. Drug Interactions: Antiarrhythmic agents. bluish marks at injection site. It should be used during pregnancy & lactation only if clearly needed. thrombocytopenia. Unstable cardiovascular status in acute hemorrhage. confusion. Comet TM Active Ingredient: Metformin HCI. narcotic analgesics. Glucoma. antipsychotic agents. Infantile colic. sympathomimetic agents. Indication: Irritable bowel syndrome. Preparation: 10 mg Tablet. clopidogrel. 60 mg (6000 anti-Xa IU/0. Product Guide Abdominal colic. Side Effect: Hemorrhage (bleeding). thrombolytics and anticoagulants. Use in Pregnancy & Lactation: Pregnancy category B. increased ocular tension. benzodiazepines. Dosage and Administration: Adults : 10 to 20 mg three to four times a day. Nursing mothers : Because the potential for hypoglycemia in nursing infants may exist. a trial of Comet XR 1000 mg twice daily should be considered. 57 Drug Interaction: Furosemide. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks. agranulocytosis.Product Guide diabetes mellitus. Comprid TM Active Ingredient: Gliclazide. Preparation: 500 mg. headache etc. diarrhoea. pancytopenia.indigestion. given in divided doses. For extended release (XR) tablet.abdominal discomfort. the daily dose may vary from 30 to 120 mg (1-4 tablets) taken orally. after severe trauma or during infections.5 mg/dL [males]. trimethoprim. Acute or chronic metabolic acidosis. Starting dose of Comet XR (metformin hydrochloride extended release tablet) is 500 mg once daily with the evening meal. gradually increased. given with meals. diabetic pre-coma & coma. pruritus. with or without coma. Dosage increases should be made in increments of 500 mg weekly. diabetes undergoing surgery. a decision should be made whether to discontinue nursing or to discontinue the drug.asthenia. flatulence. once daily. Indication: Management of type 2 diabetes mellitus.g. ranitidine. Pediatrics : Starting dose of Comet is 500 mg twice a day. Known hypersensitivity to metformin hydrochloride. vomiting. The XR tablet should be taken with food.. given with meals. severe renal or hepatic insufficiency. procainamide. up to a total of 2000 mg per day. 1 gm Tablet. Dosage & Administration: Adults : Starting dose of Comet (metformin hydrochloride tablet) is 500 mg twice a day or 850 mg once a day.Congestive heart failure requiring pharmacologic treatment. if necessary up to 320 mg daily. Contraindication and Precaution: Renal disease or renal dysfunction (e. Side Effect: Diarrhea. quinine. including diabetic ketoacidosis. given in divided doses. > 1. erythema. A single dose should not exceed 160 mg. Dosage & Administration: 40 to 80 mg daily. Dosage increases should be made in increments of 500 mg weekly up to a maximum of 2000 mg per day. the initial dose is 30 mg daily. If glycemic control is not achieved on Comet XR 2000 mg once daily. digoxin. Pregnant mothers: Pregnancy Category B. Side Effect: Hypoglycemia. rash. or vancomycin). hemolytic anaemia. even in elderly patients (>65 years). Metformin should not be used during pregnancy unless clearly needed. amiloride. dyspepsia. thrombocytopenia. cholestatic jaundice.. diabetes complicated by ketosis and acidosis. GI C . 500 mg & 1 gm XR Tablet. morphine.4 mg/dL [females] or abnormal creatinine clearance). patients known to have hypersensitivity to other sulfonylureas and related drugs. Cationic drugs (e. nausea. triamterene. quinidine. leukopenia. taking into account the importance of the drug to the mother. up to a maximum of 2000 mg once daily with the evening meal. Nifedipine. Contraindication & Precaution: Gliclazide should not be used in juvenile onset diabetes. as suggested by serum creatinine levels > 1. preferably at breakfast time. nausea.750 mg & 850 mg Tablet.g. steroids. shoulder joints & weight bearing joints of the body. chloramphenicol. Side Effect: Irritation.coumarin derivatives. palpitations.58 hemorrhage. septicaemia. Product Guide during pregnancy & lactation. acute brucellosis.MAOIs. nausea. Indication: Asthma. diarrhoea and insomnia. Preparation: 300 mg SR and 400 mg SR Tablet. peptic ulcer disease. headache. As a dietary supplement to prevent Osteoarthritis. Doses can tapered after 60 days as per requirement. Contilex® Active Ingredient: Chondroitin. corticosteroides. emphysema. diuretics and hypoxia. skin infections. Drug Interaction: Phenylbutazone. thyroid hormones. Preparation: 80 mg Tablet & 30 mg XR Tablet. tetracyclines. three times daily. Drug Interaction: Theophylline can potentiate hypokalemia resulting from b2-agonist therapy. Dosage & Administration: Tablet : 2 tablet . nocardiosis and other infections caused by susceptible organisms. Dosage & Administration: 1 . Use in Pregnancy and Lactation: Should not be used in pregnancy. sulfonamides. Mild & reversible intestinal flatulence occurs rarely. Contraindication & Precaution: Proven hypersensitivity to these ingredients is a contraindication. acute and chronic osteomyelitis. at least 1 hour before or 2 hour after meal. chronic bronchitis. clofibrate. Contraindication & Precaution: Hypersensitivity to theophylline. Use in Pregnancy & Lactation: Theophylline should not be recommended Cotrim® Active Ingredient: Sulphamethoxazole and Trimethoprim. b-adrenergic blockers. seizure disorders.2 tablets. Glucosamine + Indication: Treatment of osteoarthritis of fingers. laxatives and oral contraceptives. Preparation: (Glucosamine Sulfate 250 mg + Chondroitin Sulfate 200 mg)/Tablet. C Contifil TM Active Ingredient: Theophylline. vomiting. Side Effect: No demonstrable side effects. a fall in blood pressure. cimetidine and miconazole tablets. barbiturates. abdominal discomfort. Dosage & Administration: One tablet 12 hourly. Particular caution is advised in severe asthma. thiazide diuretics. genito-urinary tract infections. Indication: Respiratory tract infections. 3 times/day. and in patients with anaemia not caused by Iron deficiency. where the full dose of Iron required. (200 mg + 40 mg)/5 ml Suspension. Suspension : 1-2 teaspoonful twice daily. Contraindication & Precaution: The use of Iron Sucrose is contraindicated in patients with evidence of Iron overload.15 ml Defiron (3 mg Iron) per kg body weight once to three times per week depending on the haemoglobin level. Before administration of the first therapeutic dose. sulphonamides sensitivity. 59 disease (HDD-CKD) patients receiving an erythropoietin • Peritoneal dialysis dependent-chronic kidney disease (PDD-CKD) patients receiving an erythropoietin It is also indicated in the treatment of Iron deficiency anaemia in patients undergoing surgical procedures. DS Tablet : 1 tablet twice daily. pregnancy and during nursing. (800 mg +160 mg)/DS Tablet. by slow injection or directly into the venous limb of the dialyser and is not suitable for intramuscular use and for total dose infusion (TDI). Children: There is limited data on children under study conditions. glossitis. Indication: Defiron is indicated for the treatment of Iron deficiency in the following indications: • Where there is a clinical need for a rapid Iron supply • • In patients who cannot tolerate oral Iron therapy or who are non-compliant In active inflammatory bowel disease where oral Iron preparations are ineffective disease (NDD-CKD) patients receiving an erythropoietin • Non-dialysis dependent-chronic kidney • Non-dialysis dependent-chronic kidney disease (NDD-CKD) patients not receiving an erythropoietin • Hemodialysis dependent-chronic kidney . it is recommended not to exceed 0. patients donating blood. Preparation: (400 mg + 80 mg)/Tablet. postpartum patients. diarrhoea. StevensJohnson syndrome and toxic epidermal necrolysis (Lyell’s syndrome) are rare. a test dose should be given. blood dyscrasias. purpura and agranulocytosis. In severe cases. Dosage & Administration:Administration: Defiron is exclusively to be administered intravenously by drip infusion.Product Guide twice daily. It is also contraindicated in patients with history of allergic disorders including asthma. eczema and anaphylaxis.If any allergic reactions or intolerance occurs during administration. granulocytopenia. If there is a clinical need. Defiron ® D Active Ingredient: Iron Sucrose Injection. in patients with known hypersensitivity to Iron Sucrose or any of its inactive components. Normal Dosage Adults and Elderly: 5-10 ml Defiron (100200 mg Iron) once to three times a week depending on the hemoglobin level. Nausea and vomiting. the therapy must be stopped immediately. representing the patient’s total Iron deficit is administered in one complete infusion. Contraindication & Precaution: Hepatic and renal insufficiency. stomatitis. Side Effect: Exfoliative dermatitis. liver disease and infections. anemia. megaloblastic anaemia. Side Effect: Abdominal pain and epigastric pain or dyspepsia. type IIb. and oral contraceptives.2 g daily in 2 divided doses may vary between 0. -headache. not indicated in manic phase. Some of these symptoms may be seen in patients with chronic renal failure or on hemodialysis not receiving intravenous iron. Indication: Antidepressant. It is not known whether this drug is excreted in human milk. caution should be exercised when Iron Sucrose is administered to a nursing woman.5 g daily or as directed by the physician. Because many drugs are excreted in human milk. nausea. vomiting. arrhythmias (particularly heart block). blurred vision (disturbances of accommodation. unless the anticipated benefits justify the potential risk to the fetus. This drug should be used during pregnancy only if clearly needed. . Caution should be taken when used concomitantly with Lovastatin. cardiovascular sideEffects. Use in Children: Child not recommended for depression. dizziness. weight gain (occasionally weight loss) Drug Interaction: Imipramine should not be used in combination with Monoamine Oxidase Inhibitors (MAOI). Drug Interaction: anticoagulant dosage may need to be reduced. headache. type III.91. hepatic impairment. difficulty with micturation. cramps/leg cramps. blurred vision. levodopa. cimetidine. nausea. ® Delipid D Active Ingredient: Gemfibrozil. Indication: It is recommended in the treatment of type IIa. Preparation: 300 mg Capsule. severe liver disease Side Effect: Dry mouth. constipation. antipsychotic drug.60 Side Effect: Hypotension. methylphenidate. Use in Pregnancy & Lactation: Pregnancy Category-B. barbiturates. tremors. Preparation: Iron 20 mg/ml IV Injection (5 ml) Product Guide Depram TM Active Ingredient: Imipramine. Contraindication & Precaution: Alcoholism. antihypertensive agents. Dosage and Administration: 1. increased appetite. rashes and hypersensitivity reaction (including urticaria & photosensitivity). less sedation. sweating. behavioral disturbances (particularly in children) hypomania or mania (particularly in elderly). increased intraocular pressure). interference with sexual function. and diarrhea. rash. painful extremities and rarely myalgia. Use in Pregnancy & Lactation: Treatment with Imipramine should be avoided during pregnancy. blood sugar changes. anticholinergic agents. Preparation: 25 mg Tablet. gallstone. and pregnancy and to patients hypersensitive to Gemfibrozil. pruritus. Dosage & Administration: 1 tab thrice daily Contraindication & Precaution: Recent myocardial infarction. type IV and type V hyperlipoproteinemia. Product Guide 61 Indication: De-rash (Zinc Oxide) helps treat and prevent diaper rash while it moisturizes and nourishes the skin. The zinc oxide based formulation provides a protective barrier on the skin against the natural causes of irritation. De-rash (Zinc Oxide) spreads on smooth and wipes off the baby easily, without causing irritation to the affected area. Dosage & Administration: Change wet and soiled diapers promptly, cleanse the diaper area, and allow drying. Apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or anytime when exposure to wet diapers may be prolonged. Contraindication & Precaution: For external use only. When using this product avoid contact with eyes Stop use and ask a doctor if condition worsens or does not improve within 7 days. This may be a sign of a serious condition. Keep out of reach of children. If swallowed, get medical help immediately. Side Effect: Not known. Use in Children: Recommended. Preparation: Ointment 25 gm. Deprex TM Active Ingredient: Olanzapine. Indication: Acute and maintenance treatment of schizophrenia and related psychoses where positive symptoms (e.g. delusions, hallucinations, disordered thinking, hostility and suspiciousness), acute manic or mixed episodes in bipolar disorder. Dosage and Administration: The recommended starting dose for Deprex is 10 mg/day, administered as a single daily dose without regard to meals. Contraindication and Precaution: Hypersensitivity, narrow-angle glaucoma, prostatic hypertrophy, or paralytic ileus and related conditions. Neuroleptic Malignant Syndrome (NMS): unexplained high fever without additional clinical manifestations of NMS, all antipsychotic medicines, including olanzapine must be discontinued. Olanzapine should be used cautiously in patients who have a history of seizures or have conditions associated with seizures. Side Effect: Frequent: somnolence and weight gain.Occasional:dizziness,asthenia, akathisia, increased appetite, peripheral oedema, orthostatic hypotension, and mild, transient anticholinergic Effects including constipation and dry mouth; transient, asymptomatic elevations of hepatic transaminases, ALT, AST. Preparation: 5 mg and 10 mg Tablet. D Dermasol ® Active Ingredient: Clobetasol Propionate. Indication: Eczema,psoriasis,hypertrophic lichen planus, localized bullous disorders, keloid scarring, pretibial myxoedema, vitiligo. Suppression of reaction after cryotherapy. Dosage and Administration: Once or De-rash® Active Ingredient: Zinc Oxide. 62 twice daily until improvement occurs, should not be continued for more than four weeks. Contraindication and Precaution: Impetigo, tinea corporis and Herpes simplex, scabies, acne vulgaris, rosacea, gravitational ulceration. Side Effect: Adrenal suppression, prolonged and intensive treatment with a highly active corticosteroid preparation may cause atrophic changes, such as thinning, striae and dilatation of the superficial blood vessels. Use in Pregnancy and Lactation: Clobetasol Propionate should be avoided during pregnancy. Product Guide sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesion, specially where there is hyperkeratosis, the anti-inflammatory effect of Dermasol-N can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed. Elderly: Dermasol-N is suitable for use in elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur. Children: Dermasol-N is suitable for use in children (2 years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus Dermasol-N is not recommended for use in neonates and infants (younger than 2 years). Contraindication & Precaution: This medication is contraindicated in rosacea, acne vulgaris and perioral dermatitis, primary cutaneous viral infection (eg-Herpes simplex, chicken pox) and hypersensitivity to the preparation. Side Effect: Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. The effect is more likely to occur in infants and children and if occlusive dressings are used. Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved. There are reports of pigmentation changes and hypertrichosis D Use in Children: Should not be used children below the age of 12 years. Preparation: 0.05% Cream and Ointment in 10 gm & 20 gm pack. Dermasol-N ® Active Ingredient: Clobetasol Propionate BP, Neomycin Sulphate BP and Nystatin BP. Indication: Short courses treatment of recalcitrant eczemas • Neurodermatoses • Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur. Other inflammatory conditions which do not respond satisfactorily to less active steroids. Dosage & Administration:Adults: Apply Product Guide with topical steroids. Use in Pregnancy & Lactation: There is little information to demonstrate the possible effect of topically applied Neomycin in pregnancy and lactation. However, Neomycin present in the maternal blood can cross the placenta and may give rise to a theoretical risk of foetal toxicity, thus the use of the preparation is not recommended in pregnancy and lactation. The safety of Clobetasol Propionate has not been established in lactating mothers. Preparation: 15 gm Cream & Ointment 63 treatment of extensive areas, can result in sufficient systemic absorption to produce the features of hypercortisolism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. Local atrophy may occur after prolonged treatment. In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease. If signs of hypersensitivity appear with the use of Clobetasol Propionate Scalp Solution then application should be stopped immediately. Drug Interaction: Drug interaction may be observed with other potential corticosteroid containing preparation. Use in Pregnancy & Lactation:Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. The relevance of this finding to human beings has not been established; however, topical steroids should not used extensively in pregnancy, i.e. in large amounts of for prolonged periods. The safe use of Clobetasol Propionate during lactation is not been established. Use in Children: Not recommended for use in children under one year of age. Preparation: 30 ml Scalp Solution. Dermasol -S Active Ingredient: Clobetasol Propionate. Indication: It is indicated in the topical therapy of recalcitrant corticosteroidresponsive dermatoses of the scalp, including recalcitrant cases of psoriasis and seborrheic dermatitis. Dosage & administration: It should be applied once or twice daily to the affected areas of the scalp and rubbed in gently.The total dose applied should not exceed 50 ml weekly. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Dermasol-S Scalp Solution for brief periods only. Contraindication & Precaution: TM D • Infections of the scalp. • Hypersensitivity to the preparation. • Use is not indicated in dermatoses children under one year of age. Dexonex® Active Ingredient: Dexamethasone. in Indication: Various types of dermatological disorders & allergic Disorders; Severe Respiratory Disorders like - severe Bronchial Asthma, non-specific chronic Obstructive lung disease; Primary Side Effect: As with other corticosteroids, prolonged use of large amounts or 64 / secondary Adrenocortical insufficiency; Ocular inflammatory conditions which are unresponsive to topical corticosteroids; Adjunctive therapy for various rheumatic disorders; other indications where glucocorticoid therapy is required. Dosage and Administration: In general dexamethasone dosage depends on the severity of the condition and the response of the patient. Adults: Daily oral dosages vary from 1 to 10 mg, according to individual response. Children: Daily oral dosages vary from 0.03-0.20 mg/kg body weight, according to the individual response. Contraindication & Precautions: Contraindicated in patients with gastric and duodenal ulcers; systemic and ophthalmic fungal infections; viral infections - varicella and herpes genitalis infections, viral infections of the eye; glaucoma & hypersensitivity to corticosteroids. The lowest possible dose of dexamethasone should be used to control the condition under treatment. The reduction should be gradual. Dexamethasone should be used with caution in patient with osteoporosis, cardiomyopathy, hypertension, renal insufficiency, and latent tuberculosis. Side Effect: Endocrine and metabolic disturbances, fluid and electrolyte disturbances, musculo-skeletal Effects, gastro-intestinal Effects, dermatological Effects, ophthalmic Effects, CNS Effects and immunosuppressive Effects have been associated with prolonged systemic glucocorticoid therapy. Use in Pregnancy & Lactation: US FDA pregnancy category C. Glucocorticoids appear in breast milk. Mothers taking Product Guide high dosages of corticosteroids should be advised not to breast-feed. Use in Children: In order to minimize the potential growth Effects of corticosteroids, pediatric patients should be titrated to the lowest Effective dose. Preparation: 0.5 mg Tablet. Dexonex TM Eye/Ear Drops Dexamethasone Active Ingredient: Phosphate. D Indication: For the treatment of the following conditions: Ophthalmic: Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation; corneal injury from chemical or thermal burns, or penetration of foreign bodies. Otic: Steroid responsive inflammatory conditions of the external auditory meatus, such as allergic otitis externa, selected purulent and nonpurulent infective otitis externa when the hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation. Dosage and Administration: Eye: Instill one or two drops of solution into the conjunctival sac every hour during the day and every two hours during the night as initial therapy.When a favourable response is observed, reduce dosage to one drop every four hours. Later, further reduction in dosage to one drop three to four times daily may suffice to control symptoms. Product Guide Ear: Clean the aural canal thoroughly and sponge dry. Instill the solution directly into the aural canal. A suggested initial dosage is three or four drops two or three times a day. When a favourable response is obtained, reduce dose gradually and eventually discontinue. If preferred, the aural canal may be packed with a gauze wick saturated with solution. Keep the wick moist with the preparation and remove from the ear after 12 to 24 hours.Treatment may be repeated as often as necessary at the direction of the physician. Contraindication & Precaution: Epithelial herpes simplex keratitis (dendritic keratitis), acute infections stages of vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva, Mycobacterial infection of the eye, Fungal diseases of ocular or auricular structures, perforation of a drum membrane. Hypersensitivity to any ingredient of this product. The possibility of persistent fungal infections of the cornea should be considered after prolonged corticosteroid dosing. Use in Pregnancy and Lactation: US FDA Pregnancy category C. There is no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Dexamethasone ophthalmic solution is administered to a nursing woman. Pediatric Use: Safety and efficacy in pediatric patients below the age of 18 have not been established. Side Effect: Glaucoma with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex, perforation of 65 the globe. Rarely, stinging and burning may occur. Preparation: Dexamethasone Phosphate 1 mg/ml. Dexonex-C TM Eye/Ear Drops Active Ingredient: Dexamethasone Phosphate and Chloramphenicol. Indication: Eye: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists. It is also indicated in chronic anterior uveitis and corneal injury from chemical radiation or thermal burns or penetration of foreign bodies. The combination can also be used for post-operative inflammation and any other ocular inflammation associated with infection. Ear: Otitis externa, Otitis media and chronic suppurative otitis media. Dosage and Administration: Eye: Corneal Ulcers: The recommended dosage regimen for the treatment of corneal ulcer is two drops into the affected eye every 15 minutes for the first six hours and then two drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill two drops in the affected eye hourly. On the third through the fourteenth day, place two drops in the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred. Bacterial Conjunctivitis:The recommended dosage regimen for the treatment of bacterial conjunctivitis is one or two drops instilled into the conjunctival sac(s) every two hours while awake for two days and one or two drops every four hours while awake for the next five days. D dizziness. paraesthesia and headache. Indication: For the management of Diabetes Mellitus.5 mg) to 3 tablets. Caution should be exercised when Dexamethasone ophthalmic solution is administered to a nursing woman. monoamino oxidase inhibitors. Frequency should be decreased gradually as warranted by improvement in clinical signs. Diliner DR TM Active Ingredient: Duloxetine. thrombocytopenia. itching. dryness and eye pain. . cyclophosphamide. Use in Children: Safety and efficacy in pediatric patients have not been established. photophobia. tearing.). The possibility of persistent fungal infections of the cornea should be considered after prolonged corticosteroid dosing. Contraindication & Precaution: Epithelial herpes simplex keratitis (dendritic keratitis). Side Effect: Nausea. epigastric pain. Hypersensitivity to any of the components of the medication. with or without coma This contraindicated should be treated with insulin. Daily doses as directed by the physician and depending on blood sugar level. vaccinia. Mycobacterial infections of the eye. periocular/ facial edema. varicella and in many other viral diseases of the conjunctiva and cornea. D Use in Pregnancy and Lactation: US FDA Pregnancy category C. redness. Preparation: (Dexamethasone Sodium Phosphate 1 mg and Chloramphenicol 5 mg)/ ml sterile solution.66 Ear: For all infections two to three drops every two to three hours initially. Drug Interaction: Alcohol. Other reported reactions include stinging. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. dicoumarol. propranolol and other beta-adrenergic blocking agents. foreign body sensation. blurred vision. Contraindication & Precaution: Glibenclamide is contraindicated in patients with·Known hypersensitivity to the drug or any of its excipients ·Type 1 diabetes or diabetic ketoacidosis. Care should be taken not to discontinue therapy prematurely. phenylbutazone. weakness. Side Effect: Adverse reactions seen with Chloramphenicol are transient ocular burning or discomfort. Preparation: 5 mg Tablet. etc. Dosage & Administration: Half tablet (2. Fungal diseases of ocular structures. Product Guide Dibenol® Active Ingredient: Glibenclamide. Allergic skin reactions and haemopoietic reactions (leukopenia. vomiting. conjunctivitis/keratitis. Use in Pregnancy and Lactation: There is no information on the use of glibenclamide in human pregnancy. Diabetic with tachycardia. Preparation: 30 mg & 60 mg DR (Delayed Release) Capsule. 67 Dosage and Administration: 60 mg/day (given either once a day or as 30 mg BID) without regard to meals. CYP2D6 inhibitors (e. Side Effect: Bradycardia. somnolence. malaise. Use in Pregnancy and Lactation: The drug should be used during pregnancy only when the potential benefits justify the possible risk to the fetus. dry mouth. and increased sweating. sino-atrial block. hot flushes. constipation. Dosage and Administration: 90 . Betamethasone Indication: Diprobet (Betamethasone Dipropionate) cream and ointment are indicated for the relief of the inflammatory and pruritic manifestations of resistant or severe corticosteroid responsive dermatoses. dry mouth. Drug Interaction: Caution and careful dosage titration when diltiazem is administered concomitantly with other drugs that can affect cardiac contractility and/ or conduction.. anogenital and senile Diltizem® SR Active Ingredient: Diltiazem.120 mg twice daily up to 240 mg. D Diprobet® Active Ingredient: Dipropionate. atrioventricular block. Contraindication and Precaution: Known hypersensitivity. second or third degree AV block. Peripheral Neuropathic Pain. somnolence. Hypertension .Thioridazine.g. dizziness. These include. fluoxetine. fatigue.Product Guide Indication: Depression. quinidine). Indication: Angina pectoris. headache. quinolone antibiotics. hepatitis and depression reported. and asthenia. Contraindication and Precaution: Known hypersensitivity to Duloxetine. Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated. Duloxetine use should be avoided in patients with uncontrolled narrow-angle glaucoma. Use in Pregnancy and Lactation: The drug should be used during pregnancy only when the potential benefits justify the possible risk to the fetus. severe hypertension or acute myocardial infarction and pulmonary congestion. Paroxetine. contact dermatitis. hypertension. neurodermatitis. sick sinus syndrome. decreased appetite. Women receiving the drug should not breastfeed their infants. Women receiving the drug should not breastfeed their infants. Side Effect: In Duloxetine-treated MDD patients: nausea. decreased appetite. Drug Interaction: Inhibitors of CYP1A2Fluvoxamine. constipation. In Duloxetine-treated DPN patients: nausea. oedema. nummular eczema.atopic eczema. alcohol & other CNS acting drugs. Preparation: 90 mg SR Tablet. GIT disturbances. . vesiculation.5 g each of Betamethasone Dipropionate cream and ointment. Like other topical corticosteroids. usually . Premedication: 7.68 pruritus. Elderly & debilitated patients: 1-1. prickly skin/tightening or cracking of skin. other corticosteroids. also tuberculosis. varicella and Herpes simplex. skin atrophy. Contraindication & Precaution: Hypersensitivity to Betamethasone Dipropionate. or airtight dressing of an infant older than one year. acne rosacea. urticaria.5 mg (IV). perioral dermatitis and ulcerative conditions. Indication: Midazolam is used as: D • Hypnotic and hence it is used for short term management of insomnia. Insomnia: Adults: -7. irritation and folliculitis. laminar scaling and perilesional scaling. acneiform papules and hyperaesthesia. Dosage & Administration: Apply a thin film once or twice daily to cover completely the affected area.5 mg to 15 mg daily. Dormitol ® Active Ingredient: Midazolam.5 mg to 15 mg. following morning) to the previously affected areas once each week. Betamethasone Dipropionate cream and ointment should be applied to the lesion sites previously affected and treated. pruritus. such as vaccinia. Endoscopic or Cardiovascular procedures: Adult: initial dose is 2. dry skin.1 mg/Kg body weight. morning. lichen planus and psoriasis.. Elderly: -7. Use in Children: Not recommended under one year of age. erythema. follicular rash.5 mg daily. Product Guide Use in Pregnancy & Lactation: This medicine should not be used during pregnancy and during lactation unless considered essential by your doctor. twelve hours apart (e. For this purpose. tension and fear • Pre-anaesthetics • Anticonvulsants Dosage & Administration: The duration of treatment with oral midazolam should not be more than of 2 weeks. warm feeling. • Sedative and hence it relieves anxiety. evening.e. Patients with chronic psoriasis who have achieved at least a marked improvement in their psoriatic lesion (i. approximately 80% improvement) with Betamethasone Dipropionate may be maintained in remission with a pulse dosing regimen consisting of three consecutive applications of up to 3. Side Effect: The most frequent side effects reported with Betamethasone Dipropionate are mild to moderate transient burning/stinging. Induction of Anesthesia: Adult: 10-15 mg (IV) or 0. fungal skin infections. or under the nappy. In certain cases extension beyond the maximum treatment period may be necessary.5 mg (IV).g.07-0. Rarely reported adverse effects include tingling. telangiectasia. Patients on this pulse dose regimen who relapse should be reverted back to the conventional dosing regimen. should be given 30-60 minutes before the procedure. Preparation: 15 gm Cream & Ointment. Betamethasone Dipropionate is contraindicated in viral infections of the skin. milk. cholera.20 mg/Kg (IM). penicillin. other alkalis e. Children: 2. Use in Pregnancy & Lactation: . anticonvulsants and enzyme inducing drugs. Long time use of Midazolam may increase dependency. ataxia. confusion. yaws.g. tiredness. myasthenia gravis. erythromycin. muscle weakness. nausea. abdominal discomfort. patients with a history of alcohol or drug abuse and children. anticoagulants. insufficiency. Children: 0. severe hepatic insufficiency. trachoma. As Midazolam is a strong sedative. Pregnancy category D . 69 Doxacil ® Active Ingredient: Doxycycline. Contraindication & Precaution: Known hypersensitivity to Midazolam or other benzodiazepines. D Durol ® Active Ingredient: Carvedilol/ Carvedilol Phosphate. Breastfeeding is not recommended during treatment Preparation: 7.15-0.2 mg/Kg daily. Elderly & debilitated patients: 0. CNS depressants. Use in Pregnancy and Lactation: The drug should be avoided in nursing mothers and during the first trimester of pregnancy. dizziness and double vision. Dosage & Administration: 1 capsule every 12 hourly for the first day followed by 1 capsule per day. travelers diarrhea. tularemia. Doxycycline is not recommended in neonates. severe hepatic disorder. vomiting. rickettsial pox and Q fever.45 mg/Kg. rectal administration of the ampoule solution is 0. it should not be taken before driving or other performance skilled tasks. urticaria. relapsing fever. calcium. Less common side Effects are CNS depression. Rectal administration in children: for preoperative sedation. Doxycycline should not be used in pregnant women unless clearly needed. lymphogranuloma venereum. acne. actinomycosis. exfoliative dermatitis. typhus. anti-diabetic agents. sleep apnea syndrome. Indication: Respiratory tract infections. headache.0250. So caution should be taken during the concomitant treatment with these drugs along with Midazolam. Side Effect: Epigastric distress. 20-30 min before induction of general anesthesia. cellulitis furunculosis.Product Guide 5 mg (IM).05 mg/Kg (IM). Preparation: 100 mg Capsule.5 mg tablet & 15 mg/3ml injection. Drug Interaction: Should not be taken with antacids. fatigue. Side Effect: Drowsiness is the most common side Effect. These Effects occur predominantly at the start of treatment and usually disappear with dose adjustment or continuation of therapy. leptospirosis. skin rashes. severe respiratory. . azole type animycotics and cimetidine may interfere the metabolism of Midazolam. brucellosis. genitourinary tract infections.35-0. magnesium and iron. Contraindication & Precaution: Hypersensitivity. occasionally diminished peripheral circulation. then again to the target dose of 80 mg once daily • Hypertension: Starting dose is 20 mg once daily. Drug Interaction: Drug interaction have been seen with co-administration of carvedilol and digoxin. treatment should be discontinued. eye irritation or disturbed vision. Durol CR: • Heart failure: Starting dose of Carvedilol Phosphate is 10 mg once daily for 2 weeks. Patients should be maintained on lower doses if higher doses are not tolerated. dizziness.Hypertension:Monotherapy or in combination. Less frequent application may be indicated after the initial period of treatment. or severe bradycardia.5.25 mg twice daily and increase if needed for blood pressure control to 12. A lower starting dose or slower titration may be used. in the morning and in the evening).e. diuretics and ACE inhibitors. and then 25 mg twice daily over intervals of at least 2 weeks. Patients who tolerate a dose of 10 mg once daily may have their dose increased to 20. Dosage and Administration:Durol: • Heart failure: Start at 3. peripheral oedema and painful extremities. disturbances of micturition. dry mouth.70 Indication: Mild or moderate heart failure of ischemic or cardiomyopathic origin. impotence. gastrointestinal disturbances. 12. bradycardia.5 mg then 25 mg twice daily after intervals of 3 to 10 days. cardiogenic shock. Carvedilol is contraindicated in patients with hypersensitivity to the drug. Preparation: 6. After satisfactory improvement has occurred. second or third-degree AV block.This dose should also be maintained for 7 to 14 days and can then be adjusted upward to 80 mg once daily if tolerated and needed. Dosage & Administration: Adults: Calcipotriol cream & ointment should be applied topically to the affected area twice daily (i. dry eyes. Maintain lower doses if higher doses are not tolerated. in conjunction with digitalis. • Hypertension: Start at 6. and then increased to 40 mg once daily if needed . use in hepatic impairment is not recommended. headache. D Dyvon TM Active Ingredient: Calcipotriol. sick sinus syndrome Product Guide (unless a permanent pacemaker is in place). • Myocardial infarction: Starting dose is 20 mg once daily and can be increased after 3 to 10 days. Use in Pregnancy and Lactation: Not recommended. 25 mg Tablet and 20 mg CR Capsule. Contraindication: Severe chronic cardiac failure requiring intravenous inotropic therapy.5 mg then 25 mg twice daily over intervals of 1 to 2 weeks. Indication: Calcipotriol cream & ointment is indicated for the topical treatment of chronic stable plaque type psoriasis vulgaris in adult patients. based on tolerability to 40 mg once daily. the treatment may .25 mg twice daily and increase to 12. 12. If recurrence takes place after discontinuation. and 80 mg over successive intervals of at least 2 weeks.5 mg. bronchial asthma or related bronchospastic conditions. • Left ventricular dysfunction following myocardial infarction: Start at 6.125 mg twice daily and increase to 6.25. rarely angina. influenza like symptoms.25 mg. 40. fatigue. Side Effect: Postural hypotension. the dose should be maintained for 7 to 14 days. as there is inadequate experience with its use. Use in Pregnancy & Lactation: Pregnancy: Safety for use in pregnancy has not been established. Treatment should be limited to four week periods with calcipotriol used alone for one month between periods of use of Dyvon Plus Ointment as needed. Patients with severe renal insufficiency or severe hepatic disorders are also contraindicated. The maximum recommended weekly dose of Calcipotriol cream is 100gm/week. Indication: Dyvon Plus Ointment is indicated for the once daily topical treatment of plaque type psoriasis vulgaris amenable to topical therapy. Calcipotriol should not 71 be applied to the chest area during breast feeding to avoid possible ingestion by infants.Product Guide be reinstituted.The maximum recommended weekly dose of Dyvon Plus Ointment is 100 grams/week. The patient must be instructed on correct use of the product to avoid application and/or accidental transfer to the scalp. Treatment of more than 30% of the body D . Drug Interaction: There is no experience of concomitant therapy with other antipsoriatic drugs applied to the same skin area. Contraindication & Precaution: Betamethasone and Calcipotriol Ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. Use in Children: Calcipotriol cream & ointment should not be used in children. Therefore Calcipotriol should not be used during pregnancy unless benefits clearly outweigh the risks. face. Presentation: 20 gm Cream & Ointment. Patients with severe renal insufficiency or severe hepatic disorders are also contraindicated. Treatment of more than 30% of the body surface should be avoided. Contraindication & Precaution: Betamethasone and Calcipotriol Ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. The use of Dyvon Plus Ointment should be intermittent for up to one year under close medical supervision. It is also contraindicated in patients with known disorders of calcium metabolism. therefore. It is also contraindicated in patients with known disorders of calcium metabolism. Patients should be instructed to wash their hands after using Betamethasone and Calcipotriol Ointment. Dyvon Plus TM Active Ingredient: Betamethasone Dipropionate and Calcipotriol. The treated area should not be more than 30% of the body surface. Betamethasone and Calcipotriol Ointment is not recommended for use on the face since it may give rise to itching and erythema of the facial skin. Lactation:It is not known whether Calcipotriol is excreted in breast milk. Experience is lacking in the use of Calcipotriol for periods longer than 1 year. to avoid inadvertent transfer of ointment to the face from other body areas. Dosage & Administration: Dyvon Plus Ointment should be applied topically to the affected area once daily. The maximum daily dose should not exceed 15 grams. mouth or eyes. the drug should be used during lactation only if the benefits clearly out weigh the risks. Caution should be exercised Product Guide when prescribing Betamethasone and Calcipotriol Ointment to breastfeeding women. After topical use. transient changes in skin pigmentation and allergic and hypersensitivity reactions including very rare cases of angioedema and facial oedema may occur. Use in Pregnancy & Lactation: Pregnancy: Safety for use during pregnancy has not been established. the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) . and aggravation of psoriasis. Lactation: Betamethasone is excreted into breast milk. causing hypercalcaemia or hypercalciuria may appear very rarely. prednisone. There are no data on the excretion of Calcipotriol in breast milk. Due to Betamethasone content. allergic contact dermatitis. dry skin. Side Effect: Application site reactions. Use in Children: Dyvon Plus Ointment is not recommended for use in children and adolescents below the age of 18 years. pruritis. Indication: Eczena (Diflorasone Diacetate) cream & ointment are indicated for relief of the inflammatory and pruritic manifestations of corticosteroidresponsive dermatoses. to avoid inadvertent transfer of ointment to the face from other body areas. rash. If an infection develops. Contraindication & Precaution: Diflorasone Diacetate cream & ointment are contraindicated in those patients with a history of hypersensitivity to the preparation. Application of Betamethasone and Calcipotriol Ointment to the breast area should be avoided. depigmentation and colloid milia. long term use may be associated with skin atrophy. dermatitis. systemic effects. Betamethasone and Calcipotriol Ointment should only be used during lactation if the potential benefits clearly outweigh the potential risks. Preparation: Dyvon Plus Ointment: Each pack has a laminated tube containing 20 gm Ointment. Patients should be instructed to wash their hands after using Betamethasone and Calcipotriol Ointment.g.. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. skin irritation. It is unknown if topical application of Betamethasone and Calcipotriol Ointment could result in sufficient systemic absorption to produce significant quantities of this corticosteroid in human breast milk. striae. Betamethasone and Calcipotriol Ointment should only be used during pregnancy when the potential benefit clearly outweighs the potential risk. other products containing calcipotriene (calcipotriol). Drug Interaction: Caution should be taken when using other corticosteroids (e. hydrocortisone). perioral dermatitis. telangiectasia. erythema. transient photosensitivity. hypertrichosis. folliculitis. eczema. E Eczena® Active Ingredient: Diflorasone Diacetate.72 surface should be avoided. Dosage & Administration: Apply to the affected area as a thin film from one to four times daily depending on the severity of the condition. burning and stinging sensation. irritation. Manifestations of intracranial hypertension include bulging fontanelles. Cushing’s syndrome. especially with higher potency corticosteroids. headaches. If HPA axis suppression is noted. Nevertheless. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Therefore. skin atrophy. Preparation: Eczena 0. allergic contact dermatitis. and the addition of occlusive dressings. and they may occur more frequently with the use of occlusive dressings. and miliaria. manifestations of Cushing’s syndrome. therefore. perioral dermatitis. Manifestations of adrenal suppression in pediatric patients include linear growth retardation. secondary infections. HPA axis suppression. Infrequently. an attempt should be made to withdraw the drug. E Efigrel TM Active Ingredient: Hydrochloride. and bilateral papilledema. Prasugrel Indication: Efigrel is indicated to reduce the rate of thrombotic cardiovascular (CV) . signs and symptoms of steroid withdrawal may occur. and glucosuria in some patients.05% Ointment . They are. striae. requiring supplemental systemic corticosteroids. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Side Effect: The following local adverse reactions have been reported infrequently with topical corticosteroids. patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. Eczena 0. Use in Children: Safety and effectiveness of Eczena (Diflorasone Diacetate) cream & ointment in pediatric patients have not been established. also at greater risk of glucocorticosteroid insufficiency after withdrawal of treatment and of Cushing’s syndrome while on treatment. acneiform eruptions. Nursing Mothers It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. use over large surface areas. or to substitute a less potent steroid. itching. and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids.05% Cream . hyperglycemia. and absence of response to ACTH 73 stimulation. delayed weight gain. Because of a higher ratio of skin surface area to body mass.Product Guide axis suppression. hypopigmentation.Each pack has a tube containing10 gm cream. Use in Pregnancy & Lactation: Pregnancy Category C. These reactions are listed in an approximate decreasing order of occurrence: burning. dryness. caution should be exercised when topical corticosteroids are administered to a nursing woman. to reduce the frequency of application.Each pack has a tube containing 10 gm ointment. Conditions which augment systemic absorption include the application of the more potent steroids. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in pediatric patients. pediatric patients are at greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids. low plasma cortisol levels. folliculitis. prolonged use. Treatment with a dose of 10 mg should be contemplated until patients have been on a daily dose of 5 mg for 4 to 6 weeks. Contraindication and Precaution: Hypersensitivity to Donepezil hydrochloride or to piperidine derivatives. dizziness. muscle cramp. Side Effect: The most common adverse events include nausea. Patients taking Prasugrel should also take aspirin (75 mg to 325 mg) daily. Use in Children: Safety and Effectiveness in pediatric patients have not been established. • Patients with unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI). Dosage & Administration: Prasugrel should be initiated with a single 60 mg loading dose and then continued at 10 mg once a day. severe hepatic impairment. Prasugrel may be administered with or without food. Dosage and Administration: 5-10 mg once daily in the evening just prior to retiring. active pathological bleeding. Use in Pregnancy & Lactation: Pregnancy Category B.74 events (including stent thrombosis) in patients with acute coronary syndrome (ACS) who are to be managed with percutaneous coronary intervention (PCI) as follows: Product Guide and NSAIDs (used chronically) may increase the risk of bleeding. rash & peripheral edema etc. fatigue and anorexia. insomnia. • Patients with ST-elevation myocardial infarction (STEMI) when managed with primary or delayed PCI. vomiting. and history of stroke or transient ischaemic attack (TIA). There are no adequate and well-controlled studies of Prasugrel use in pregnant women. may happen. headache. Contraindication & Precaution: Prasugrel should be avoided in case of hypersensitivity to the active substance or to any of the excipients. A treatment of up to 12 months is recommended. bradycardia. unless the discontinuation of Prasugrel is clinically indicated. . In case of patients weighing ≤ 60 kg or patient’s ≥ 75 years old. Preparation: 5 mg & 10 mg Tablet. Besides this hypertension. Prasugrel should be given as a single 60 mg loading dose and then continued at a 5 mg once-daily dose. Indication: Indicated for the treatment of mild to moderate dementia of the Alzheimer’s type. Coadministration of Prasugrel E Elzer® Active Ingredient: Donepezil. Drug Interaction: Coadministration of prasugrel and warfarin increases the risk of bleeding. diarrhea. Side Effect: Bleeding (non-CABG related & CABG related) and Thrombotic thrombocytopenic purpura. Use in Pregnancy and Lactation: Donepezil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. back pain. Prasugrel should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. cough. Contraindication & Precaution: Hypophosphatemia. gramnegative septicaemia. sour stomach or hiatus hernia. ® . hypermagnesemia. Indication: For treatment of infections caused by mecillinam-sensitive organisms. Dosage & Administration: Two tablets/ two teaspoonful suspension 1-3 hours after meal and at bed time. heartburn. 75 Entacyd ® Emcil ® Active Ingredient: Aluminium Hydroxide & Magnesium Hydroxide. Use in Pregnancy and Lactation: Pivmecillinam in pregnancy should be prescribed when the expected benefits are considered to be greater than the potential risk. vomiting and diarrhoea or indigestion may occur when a dose has been given on an empty stomach. shigellosis. Side Effect: Long term use may cause alkaluria. Children: weighing less than 20 kg should be given 20-60 mg/kg divided into 3-4 daily doses. gastrointestinal disturbances such as nausea.g. gastritis. The tablet should be taken with at least 50-100 ml fluid. Preparation: 5 mg Tablet. alkalosis. complicated urinary tract infections. heartburn. Dosage and Administration: Adults: The usual dose is 1-2 tablets 3 times daily according to severity of the infection. enteropathic E. constipation or regurgitation. peptic ulcer. Preparation: Tablet and Suspension. salmonellosis. Side Effect: Diarrhea. coli diarrhoea. peptic oesophagitis. Contraindication and Precaution: There have been no reports on allergy to Pivmecillinam among patients with a known history of hypersensitivity to penicillins and cephalosporins. gastric hyperacidity. Preparation: 200 mg Tablet. peptic ulcer. & nephrolithiasis. Contraindication & Precaution: Renal failure or hypophosphatemia. e. Magnesium Hydroxide & Simethicone Indication: Hyperacidity. Dosage & Administration: 1-2 tablets/1-2 teaspoonful suspension 1-3 hours after meal and at bed time.Product Guide Donepezil has no indication for use in nursing mothers. Those weighing more than 20 kg should receive normal adult dose. Skin rashes have been reported in some cases. sour stomach and dyspepsia. gastritis. Active Ingredient: Pivmecillinam. E Entacyd Plus Active Ingredient: Aluminium Hydroxide. Indication: Hyperacidity. hypermagnesemia. Mecillinam is not excreted into the milk of lactating mother. Side Effect: Generally well tolerated. billiary infections. acute cystitis. have hepatic damage. When being prescribed to overcome insomnia.Adults: 100 to 320 mg. tension and fear. Less common side Effects are CNS depression. Caution should be taken in patients. lethargy. Children: IV 15 to 20 mg/kg over 10 to 15 min. Antiepileptic in epilepsy with Partial seizure or Generalized Tonic-clonic seizure. Pre-anaesthetics. Repeat if needed. Epilepsy-Adults: 60 to 250 mg/day. Max IV rate 60 mg/min. For 10 days. nightmares. SedationAdults: PO 30 to 120 mg/day in 2 to 3 divided doses. suicidal tendencies or a history of drug abuse. Preoperative SedationChildren: PO / IM / IV 1 to 3 mg/kg. Epilepsy and other seizure disorders. Dosage & Administration: Children : Infants and children (up to 10 years of . 100 ml Elixir. Sedation. mental depression. AnticonvulsantChildren: IM / IV 4 to 6 mg/kg/day. Epinal Injection: InsomniaAdults: PO / IM / IV 100 to 320 mg. Product Guide Epinal ® Active Ingredient: Phenobarbital. alone or as an adjunct in the management of myoclonic and akinetic seizures and petit mal variant (Lennox-Gastaut syndrome). Repeat if needed (max. concentration. use IM / IV 10 to 15 mg/kg/ day to reach therapeutic level more quickly. hypnotic and hence it is used for short term insomnia. restlessness and confusion in the elderly and hyperkinesia in children. nervousness. agitation. Use in Pregnancy & Lactation: Contraindicated during pregnancy & lactation Preparation: 30 mg & 60 mg Tablet. Side-Effect: Drowsiness is the most common side Effect. bradycardia. vomiting. who are mentally depressed. Alternatively. Preoperative Sedation-Children: 1 to 3 mg/ kg. nausea. E Epitra® Active Ingredient: Clonazepam. the drug should not be used for a period longer than two weeks. ataxia. then adjust to blood level. Status epilepticus. psychiatric disturbance. Dosage & Administration: Insomnia. ConvulsionsAdults: IV 100 to 320 mg. Indication: Epinal is indicated as sedative and hence it relieves anxiety. 600 mg/24 hr). EpilepsyAdults: PO 60 to 250 mg/day. constipation. anti convulsant. Indication: Anxiety as well as panic disorder. 200 mg/ ml injection. with or without agoraphobia.Adults: 30 to 120 mg/day in 2 to 3 divided doses. apnea.76 Preparation: Tablet and Suspension. Phenobarbital is potentially habit forming if taken over an extended period of time. Status EpilepticusAdults: IV 10 to 20 mg/kg. Max adult IM dose is 500 mg or 5 ml volume regardless of Contraindication & Precaution: Phenobarbital is contraindicated in patients with acute intermittent porphyria and who have a natural or idiosyncrasy to barbiturates. Haemorrhoids postpartum.01 and 0. Dosage may be increased in increments of 0.03 mg/kg/day and should not exceed 0. insert to full extent and squeeze tube gently from lower end whilst withdrawing. phenothiazines.1 to 0. . clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonic seizures.50 mg every third day until a maintenance dose of 0. Preparation: 0. Pregnancy category : D Side Effect: Drowsiness.2 mg/kg of body weight has been reached. anticonvulsant drugs. Drug Interaction: Alcohol. Anal pruritus. E Erian® Active Ingredient: Cinchocaine Hydrochloride + Hydrocortisone + Framycetin Sulphate + Esculin. Maintenance dose for adults is 8 to 10 mg/day in three divided doses. peri-anal eczema. Indication: Internal and external haemorrhoids. psoriasis. Equra® Active Ingredient: Urea.25 to 0. For deep application attach applicator/cannula (supplied) to tube. sensitivity to benzodiazepines. mono amino oxidase inhibitors and tricyclic antidepressants. antianxiety agents. on the painful or pruritic area.5 mg. Dosage should be increased by no more than 0.5 mg/day divided into three doses. narrow angle glaucoma. Contraindication & Precaution: Significant liver disease. anal fissures and proctitis. Gradual withdrawal is essential when discontinuing clonazepam. When used in patients in whom several different types of seizures co-exist. Use in Pregnancy and Lactation: Equra cream can be used during pregnancy and lactation.Product Guide age or 30 kg of body weight)-Between 0. barbiturates. Adults : Initial dose should not exceed 1. morning and evening and after each stool. Behaviour problems and increased salivation. Preparation: 10% Cream. If the condition is aggravated or there is no improvement the doctor should be consulted. Ataxia. Dosage and Administration: Twice daily. 77 Indication: Ichthyosis and dry skin conditions. when applied to sensitive skin. Side Effect: Burning and irritation.5 to 1 mg every three days until seizures are adequately controlled. eczemas. if applied to inflamed. Posthaemorrhoidectomy application to relieve pain and discomfort. unless seizures are controlled or side Effects preclude further increase. broken or exudative skin eruptions. Equra can be used in all age groups. Dosage and Administration: Apply the ointment in small quantity with the finger.05 mg/kg/day given in 2 or 3 divided doses. nonbarbiturate hypnotics. narcotics. Contraindication and Precaution: local irritation and edema. 2 mg Tablet & 10 ml oral drops. . Ancylostomiasis. Drug Interaction: Concomitant treatment with cimetidine may inhibit the metabolism of mebendazole in the liver. Indication: Treatment of pinworm. Contraindication: Hypersensitivity to any of the ingredients.78 Contraindication and Precaution: Known hypersensitivity to any of the four ingredients. alternative to a tetracycline in mycoplasma pneumonia. Use in Pregnancy: Should not be administered during pregnancy. rheumatic fever prophylaxis. Trichuriasis : 2 tablets in two divided doses for 3 consecutive days or 2 teaspoonful (10 ml) in two divided doses for 3 consecutive days. herpes simplex. Preparation: 100 mg Tablet & 100 mg / 5 ml Suspension. penicillinresistant staphylococcal infections. Eromycin® Active Ingredient: Erythromycin. Children: 1 tablet or 1 teaspoonful (5 ml) twice daily for 3 consecutive days. telangiectasiae and ecchymoses. whip worm. during pregnancy. pertussis. Use in Pregnancy and Lactation: During pregnancy. Use in Children: Not recommended. Enterobiasis : A single tablet or 1 teaspoonful (5 ml) of the suspension. Preparation: Each gram ointment contains Cinchocaine Hydrochloride 5 mg+Hydrocortisone 5 mg+Framycetin Sulphate 10 mg+Esculin 10 mg. chronic bronchitis. Side Effect: Long-term continuous treatment causes atrophic changes in the skin leading to thinning. round worm. hookworm. The possibility. Use in Children: Should be used in children over 2 years. Side Effect: Transient abdominal pain and diarrhoea. in large amounts or for prolonged periods of time. or tuberculous infection of the anal region. Discontinue use if sensitization occurs. it should not be used unnecessarily on extended areas. Product Guide Ascariasis. vaccinia or varicella. resulting in increased plasma concentrations of the drug especially during prolonged treatment. tape worm and threadworm in single or mixed infections. Taeniasis & strongyloidiasis : Adults : 2 tablets twice daily for 3 consecutive days. diphtheriaespecially in treatment of the carrier state. otitis media and chronic prostatitis. however rare. Dosage & Administration: Ermox 100 mg tablet and Ermox suspension have the same dosage schedule applies to adults & children. Indication: Alternative to a penicillin in penicillin-sensitive patients. loss of elasticity. E Ermox® Active Ingredient: Mebendazole. Drug Interaction: Proper data is not available. dilatation of superficial blood vessels. that prolonged use of this preparation might produce systemic corticosteroid Effects. eye irritation. Digoxin. 100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Ergotamine. 79 Use in Pregnancy and Lactation: Use with caution. . 2 to 10 mg/kg body weight per day should be used. If dosage on a mg/kg body weight basis is required. Active Ingredient: Erythromycin. Dosage in Children: Children under 15 years: 10 to 20 mg/kg body weight per day up to a maximum of 400 mg daily. Contraindication & Precaution: Hypersensitivity to Erythromycines.5-5%) adverse Effects. Dosage & Administration: Allopurinol should be introduced at low dosage e. The following dosage schedules are suggested: • 100 to 200 mg daily in mild conditions. Warfarin. Preparation: 500 mg and 250 mg Tablet. Drug Interaction: Theophylline. Carbamazepine. Dosage in the elderly: In the absence of specific data. 125 mg/5 ml Dry Powder for Syrup. cholestatic jaundice. Dosage and Administration: Apply in morning and evening to the affected areas. E Eromycin ® Lotion • 700 to 900 mg daily in severe conditions. Indication: Primary and secondary gout. Indication: Acne. desquamation. arthralgias. Children : 30-50 mg/ kg/day. Side Effect: Nausea. gastrointestinal disturbances and allergy being the commonest ( 0. Contraindication and Precaution: Hypersensitivity to any of its ingradient.g. 200 mg/5 ml Paediatric Drops. impaired hepatic function. Use in Pregnancy and Lactation: There is no evidence that the use of erythromycin is hazardous in pregnancy though it does cross the placental barrier. Dosage in renal impairment: In severe renal insufficiency. fever. chill. dryness or oily skin. tenderness. Drug Interaction: Clindamycin interacts with Erythromycin. Esloric® Active Ingredient: Allopurinol. • 300 to 600 mg daily in moderately severe conditions. eosinophilia and mild leukocytosis or leukopenia. Side Effect: Erythema. it may be advisable to use less than 100 mg /day or to use single doses of 100 mg at longer intervals than one day. the lowest dosage which produces satisfactory urate reduction should be used. pimples & bacterial skin infections susceptible to Erythromycin. burning sensation. Preparation: 25 ml Lotion. Side Effect: Pruritic maculopapular skin eruptions. Extra caution should be exercised if renal function is poor.Product Guide Dosage & Administration: Adults : 1-2 gm daily in divided doses. known sensitivity to nitrates. Contraindication & Precaution: Obstructive hypertrophic cardiomyopathy. abdominal pain. tricyclic E Contraindication & Precaution: Acute myocardial infarction with low filling pressure. neuroleptics and . Tachycardia. alcohol. Diuretic. or very low blood pressure. Inferior myocardial infarction with right ventricle involvement. Side Effect: Nausea. Side Effect: Headache may occur at the start of treatment. Preparation: 100 mg & 300 mg Tablet. Raised intracranial pressure. Infrequently nausea. Product Guide Use in Pregnancy and Lactation: Use only when clearly needed. vertigo and dizziness are less common. headache. Longterm treatment and prophylaxis of angina pectoris. vomiting. shock. Drug Interaction: Calcium blockers. apprehension. palpitations and orthostatic hypotension are common symptoms. acute circulatory failure. restlessness and weakness. cerebral haemorrhage. channel agents. Arterial hypoxaemia and corpulmonale. Mitral valve prolapse. Cardiac tamponade. vascular collapse. Symptoms of circulatory collapse may arise after the first dose in patients with labile circulation. Esmo® LA Active Ingredient: Mononitrate. Dosage and Administration: capsule once daily. Congestive heart failure. but this usually disappears after a few days. severe hypotension or hypovolaemia. ACE inhibitors. Dosage and Administration: 20 mg (1 tablet) twice daily. Symptoms of postural hypotension and syncope may result in some patients. Use in Pregnancy and Lactation: This drug should be used during pregnancy only if clearly indicated. Preparation: 20 mg Tablet. head trauma. sildenafil. flushing and allergic rashes can occur. urinary and faecal incontinence. Glaucoma. Isosorbide Indication: Prophylaxis and treatment of angina. marked anaemia. ACE inhibitors. vomiting. alcohol. Cytotoxic agent. arterial vasodilators. antihypertensive phenothiazines and antidepressants. Isosorbide Indication: Long-term treatment of blood-flow disorders of the coronary vessels (coronary heart disease). calcium antagonists. Low cardiac output secondary to hypovolaemia.80 Drug Interaction: Anticoagulant. vasodilators. diuretics. One Esmo® Active Ingredient: Mononitrate. Treatment of severe myocardial insufficiency (chronic heart failure) in combination with cardiac glycosides. Drug Interaction: Beta-blockers. caution should be exercised when Allopurinol is administered to a lactating mother. Fatigue. cystitis. 1-3 times daily. . diarrhea or E Drug Interaction: Vitamin A. Betterment of Skin & Hair: 200 mg . Sickle-cell anemia: 400 mg / day. Indication: Spastic conditions of the gastrointestinal tract. when used as recommended doses. Higher doses are not established. 3 times daily. Children (1-6 years) : 1/4 to 1/2 tablet 1-2 times daily. Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis. 1-2 times daily. Deficiency syndrome in adults: 200 mg 400 mg / day. For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.400 mg / day (Topical use is also established for beautification) Chronic cold in adults: 200 mg / day. Thalassemia: 800 mg / day. uterine tetanus. Side Effect: Rarely nausea. Evit® Active Ingredient: a-Tocopheryl Acetate (Vitamin E) Indication: Vitamin E deficiency. 200 mg and 400 mg Licap. Children (over 6 years): 1/2 to 1 tablet. Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis. vomiting and Dosage & Administration: Betterment of Cardiovascular health: 400 mg . Dosage and Administration: Espa tablet: Adults: 1 to 2 tablets.animal studies having shown no hazard. Contraindication and Precaution: Caution should be taken for patients suffering from liver and kidney disease. Spastic conditions of the uterus: Dysmenorrhea. Contraindication & Precaution: No absolute contraindication. Preparation: 50 mg LA (Long Acting) Capsule. Use in Pregnancy and Lactation: Vitamin E is safe in pregnancy and lactation. intramuscularly or subcutaneously. pyelitis. 81 Preparation: 40 mg Tablet and 40 mg/2 ml Injection. hypotension. imminent abortion.800 mg / day. cholecystitis. Use in Pregnancy and Lactation: There is inadequate evidence of safety of the drug in human pregnancy but nitrates have been used widely in the treatment of angina for many years without apparent ill consequence.Product Guide tricyclic antidepressants. irritable bowel syndrome. cholangitis. Deficiency syndrome in children: 200 mg / day. Espa TM Active Ingredient: Drotaverine HCI. Preparation: 200 mg Chewable Tablet. Side Effect: myopathy. K & Warfarin. Drug Interaction: Levodopa. Nevertheless it is not advisable to use this drug during pregnancy and lactation. Espa Injection: Adults: 1 to 2 ampoules. The most side Effects include abdominal pain. Patients who have previously suffered tendon damage with fluoroquinolones. Dosage and Administration: Up to 4 times daily.g. hypersensitivity to the preparations. candidiasis. Contraindication and Precaution: Skin lesions caused by infection with viruses (e. care is needed to ensure that the preparation does not enter the eye as glaucoma might result. one or two times daily or as directied by the physician. dermatitis & otitis externa. rash and vomiting. Side Effect: Hypersensitivity. anticoagulants.g. For CommunityAcquired Pneumonia (CAP) in mild to moderate severity once daily for 5 days & in severe cases once daily for 7 days.or magnesium-containing antacids and iron salts are concomitantly administered. estrogens. Contraindication and Precaution: Hyperoxaluria.g. Dosage & Administration: In Acute Exacerbations of Chronic Bronchitis (AECB) once daily for 5 days. exacerbation of symptoms may occur. Facticin TM Active Ingredient: Gemifloxacin 320 mg Indication: Acute Exacerbations of chronic bronchitis. Use in Pregnancy and Lactation: There is inadequate evidence of safety in human pregnancy & lactation. Gemifloxacin should be taken at least 2 hours before or 3 hours after these agents. Community-acquired pneumonia. fatigue and weakness.82 Product Guide Eyevi ® hypertrichosis. abdominal pain. fungi (e. diarrhea. Side Effect: Diarrhea. Dosage and Administration: One Eyevi capsule. Active Ingredient: Vitamin C + Vitamin E + Zinc + Copper + Lutein Indication: Age-related Eye Disease. transient adrenal suppression. impetigo). Adequate hydration of patients receiving Gemifloxacin should be maintained to prevent the formation of a highly concentrated urine and crystalluria. Contraindication & Precaution: Known hypersensitivity to Gemifloxacin and other quinolones. vitamin-K. Herpes Simplex. Side Effect: Generally well tolerated. headache. tinea) or bacteria (e. nausea. . Gemifloxacin should F Preparation: (60mg + 30 mg + 15 mg + 2 mg + 6 mg)/Capsule. chicken pox). Ezex® Active Ingredient: Clobetasone Butyrate. and other gastrointestinal disturbances. Indication: Eczema. local atopic changes. If applied to the eyelids. Drug Interaction: Gemifloxacin absorption is significantly reduced when aluminium. Preparation: 25 gm Cream and Ointment. 1-2 mg/day) is reached. A diagnostic aid in case of a doubtful Famotack® Active Ingredient: Famotidine. A missed dose should be taken as soon as remembered. Maintenance therapy as Famotack 20 one tablet at night. The safety and efficacy of Gemifloxacin in pregnant or lactating women have not been established. Use in Pregnancy & Lactation: Gemifloxacin should not be used in pregnant or lactating women. Preparation: Facticin Tablet: Box containing 1x6’s Alu-Alu blister packs. constipation and diarrhoea. Gastritis. followed by a gradual reduction. Preparation: 20 mg and 40 mg Tablet. • For the prevention of recurrent infections of the vagina and lower urinary tract.and postoperative therapy in postmenopausal women undergoing vaginal surgery: 4-8 mg/day in the 2 weeks before surgery.and postoperative therapy in postmenopausal women undergoing vaginal surgery. Indication: a . Climacteric complaints such as hot flushes and night sweating: 4-8 mg/day during the first weeks. unless it is more than 12 hours overdue. Dosage & Administration: 20 mg twice daily or 40 mg at night. Dosage & administration: It is important that the total daily dose is taken at one time.g. . dryness and itching. In the latter case the missed dose should be skipped and the next dose should be taken at the normal time. Atropy of the lower urogenital tract: 4-8 mg/day for the first weeks. anorexia. rash. Pre. Indication: Duodenal ulcer. dizziness. 1-2 mg/day in the 2 weeks after surgery. For maintenance therapy the lowest Effective dosage should be used. abdominal discomfort or distention. Use in Children: Not recommended below 18 years of age. Pre.Atrophy of the lower urogenital tract related to oestrogen deficiency. nausea and/ or vomiting. It is best avoided by nursing mothers.Product Guide be taken at least 2 hours before sucralfate administration. b. Gastro-oesophageal reflux disease and Zollinger-Ellison syndrome. fatigue. until a maintenance dosage (e. It may be taken with or without food. based on relief of symptoms. followed by a gradual reduction. Gastric ulcer. • In the management of micturition complaints (such as frequency and dysuria) and mild urinary incontinence. 83 Femastin® Active Ingredient: Estriol. particularly - • For the treatment of vaginal complaints such as dyspareunia. Use in Pregnancy & Lactation: Should be prescribed only if clearly needed. Contraindication Hypersensitivity & Precaution: F Side Effect: Headache. In pregnancy. undiagnosed vaginal bleeding. barbiturates. Dosage & Administration: 1 capsule three to four times daily. hydantoins and rifampicin may possibly decrease the Effectiveness of estriol. leg cramps and vision disturbances are seldom observed. that concurrent use of estriol with activated charcoal. Use in Pregnancy and Lactation: There is no contraindication in pregnancy and lactation. Product Guide Indication: Iron and Folic acid deficiency. Fexo TM Active Ingredient: Fexofenadine. mainly obtained with other estrogens or oral contraceptives. hypertension. Norfloxacin. nausea. Tetracyclines. Drug Interaction: Antacid. Side Effect: Generally well tolerated. untreated endometrial hyperplasia. spotting. Fexofenadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. anticonvulsant drug. Preparation: Each box contains 30 tablets in blister pack. estriol included. as estriol is excreted in the milk and it may decrease the quality and quantity of the milk production. In general. Ciprofloxacin and Ofloxacin. Folic acid. diarrhoea. abdominal cramps. Side Effect: Breast tension or pain. Contraindication & Precaution: Fexofenadine is contraindicated in patients with known hypersensitivity to any of the ingredients. If necessary. Use in Pregnancy & Lactation: Use Femastin in breastfeeding women only if really needed.84 atrophic cervical smear: 2-4 mg/day for 7 days before taking the next smear. Known or suspected estrogen-dependent tumors. allergic reaction. Contraindication Pernicious anaemia. Headache. Preparation: (Ferrous Fumarate 200 mg + Folic acid 0. fluid retention and cervical hypersecretion may occasionally occur and be indicative of too high dosage. known or suspected breast cancer. 1 capsule daily. the dosage of the corticosteroid should be reduced.2 mg)/Capsule. F Drug Interaction: There are strong indications that estrogens. & Precaution: Side Effect: Gastric distress. Use in Pregnancy & Lactation: There are no adequate and well controlled studies in pregnant women. Contraindication & Precaution: Pregnancy. There are also some indications. most of these adverse reactions disappear after the 1st week of treatment. can increase the pharmacologic Effects of certain corticosteroids. Penicillamine and Zinc. Indication: Seasonal & perennial allergic rhinitis & Chronic idiopathic urticaria. It is not known if Fexofenadine is excreted Fe-plus® Active Ingredient: Ferrous Fumarate and . Preparation: 60 mg. F Fexo Plus TM Active Ingredient: Fexofenadine HCl + Pseudoephedrine HCl .A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.Product Guide 85 in human milk. Dosage & Administration: Patient Population Adults and Children 12 years and older 60 mg twice daily or 120 mg once daily or 180 mg once daily Fexo Tablet Fexo Oral Suspension In case of decreased renal function 60 mg once daily is recommended as the starting dose 30 mg (5 ml) once daily is recommended as the starting dose ----- Children 6 to 11 years Children 2 to 5 years 30 mg twice daily 30 mg (5 ml) or 60 mg once twice daily daily --------- 30 mg (5 ml) twice 30 mg (5 ml) once daily daily is recommended as the starting dose 15 mg (2. Caution should be exercised when Fexofenadine is administered to a nursing woman. itchy/watery/red eyes. and nasal congestion. Indication: For the relief of symptoms associated with seasonal and perennial allergic complications in adults and children 12 years of age and older. itchy nose/palate/ and/or throat. Dosage & Administration: The recommended dose of Fexo Plus Tablet is one tablet twice daily administered on an empty stomach with water for adults and children 12 years of age and older. 180 mg Tablet and 30 mg / 5 ml Suspension. Symptoms treated Effectively include sneezing. care should be taken in dose selection and it may be useful to monitor renal function. It should be administered when both the antihistaminic properties of Fexofenadine Hydrochloride and the nasal decongestant properties of Pseudoephedrine Hydrochloride are desired.5 ml) twice daily 15 mg (2. rhinorrhea. 120 mg. It is recommended that the administration of Fexo Plus Tablet with food should be avoided.5 ml) once daily is recommended as the starting dose Children 6 months to less than 2 years In case of decreased renal function. . Children (6 months to 14 years of age with sleep disorders): 0. to correct the symptoms of anorexia. nervousness. Drowsiness may be experienced within 30 minutes after taking melatonin and may persist for 1 hour and thus may affect driving skills. Phosphorous. Attention Deficit Hyperactivity Disorder in Children. Manganese. tablet contains F Preparation: Fexofenadine HCl 60 mg + Pseudoephedrine HCl 120 mg Bi-layer Tablet. headache. Pantothenic acid. Vitamin B6. Thiamine. Folic acid. Selenium. Preparation: Each Melatonin 3 mg. Product Guide at bedtime when in the new time zone. anxiety. Zinc.agitation. Filfresh® Active Ingredient: Melatonin. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Take a preflight early evening treatment followed by treatment at bedtime for 4 days after arrival. Niacin. Iron. Caffeine and fluvoxamine may increase the Effects of melatonin. Side-Effect: Possible side Effects may include headache and depression.Take for 4 days Filwel Gold Active Ingredient: Vitamin A. Use in Children: Recommended for the use in children of 6 months and above. in sarcoidosis and jet lag. Dosage & Administration: Adult: Insomnia: 3-6 mg one hour before bedtime Jet lag: 0. Biotin. Vitamin B12. Iodine.125 mg twice in the late afternoon. in menopause to regulate sleep patterns in peri or postmenopausal women. Sarcoidosis: 20 mg per day for 4 to 12 months. nausea. 1 to 5 mg 1 hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival at final destination. Eastbound travel . K. Molybdenum. Magnesium. Caution should be exercised when this drug is administered to nursing women. while melatonin may decrease the antihypertensive Effect of nifedipine. dizziness. and palpitation etc. Depression: 0. Chromium.3 mg/day Contraindication & Precaution: Melatonin should not be used by patients who have autoimmune diseases. Use in Pregnancy & Lactation: Information regarding safety and efficacy in pregnancy and lactation is lacking. Westbound travel . C. ® . each dose 4 hours apart. Calcium. Use in Children: This drug is not recommended for pediatric patients under 12 years of age.86 Contraindication: This drug is contraindicated in patients with known hypersensitivity to any of its ingredients. Indication: Insomnia.5 to 5 mg one hour prior to bedtime at final destination or. Difficulty falling asleep: 5 mg 3 to 4 hours before an imposed sleep period over a 4-week period. Side-Effect: The reported side Effects are insomnia. E. Use in Pregnancy & Lactation: Category C. osteoporosis. Riboflavin. Copper. dry mouth. D. Boron. Silicon. Potassium. Children (> 4 years): One & half teaspoonful ® Preparation: 100 ml & 200 ml Syrup. It stimulates appetite and improves digestion. promotes healthy hair. Calcium. Vitamin D. Contraindication & Precaution: Known hypersensitivity. Vitamin E & Nicotinamide. Indication: Treatment of vitamin and mineral deficiencies above the age of 45 years. Then. Zinc. Copper. chest and bronchial troubles. helps maintain healthy muscles and nervous system & helps optimizing brain development. Not formulated for use in children. Tin. Boron. this medicine may accumulate in the body which may cause hypervitaminosis of the related fat soluble vitamins. Preparation: Tablet. Indication: Filwel Kids Syrup helps preventing vitamin deficiencies in children & adult. large dose of vitamin A may increase the risk of osteoporosis. ® . Side Effect: Diarrhorea. Potassium. other gastrointestinal disturbances. Women of child bearing age (including pregnancy & lactation): One teaspoonful daily. Side Effect: Generally well tolerated. Vanadium and Lutein. Use in Pregnancy and Lactation: Recommended by the consultation with physician. Thiamine. C. Vitamin B12. skin may assume slightly yellow discoloration. Chromium. Nickel. Contraindication & Precaution: The product is contraindicated in patients with a known hypersensitivity to any of the ingredients of this product. good vision. Vitamin B6. Chloride. D. Vitamin B2. colds. Filwel Silver Active Ingredient: Vitamin A. E. skin and nails. 87 daily. Vitamin B1. Vitamin C. It can be taken with water or milk if desired. Dosage & Administration: One tablet daily with food. & Lactation: F Use in Children: Recommended. Dosage & Administration: Infants (<1 year): Half teaspoonful daily. Use in Pregnancy Recommended. Adults: Two teaspoonful daily. Manganese. Indication: Treatment of vitamin and mineral deficiencies. Filwel Kids Active Ingredient: Cod Liver Oil. Dosage & Administration: One tablet daily with food. Nickel. Not formulated for use in children. Vitamin A. Iodine. Magnesium. Phosphorous. Pantothenic acid. it should not be used over dosage or be used continuously except recommended by the physicians. Vitamin B6. Niacin.Product Guide Chloride. Folic acid. Biotin. increases resistance against coughs. Molybdenum. K. strong bones and healthy teeth. In the long term use. Riboflavin.4 years): One teaspoonful daily. Vanadium and Lutein. Children (1 . Selenium. Silicon. rheumatoid arthritis and ankylosing spondylitis. Product Guide Indication: Osteoarthritis. digoxin. methotrexate. Dosage and Administration: Children (<2 years) : 20 mg (0. Side Effect: Dyspepsia.6 ml) 4 times daily. Side Effect: No adverse Effect has been noted after oral ingestion. Dosage and Administration: 100 mg twice daily. Adults: 40-80 mg (0. anticoagulants.1. F Flacol ® Active Ingredient: Simethicone. nausea and diarrhea. diuretics. gas and windy colic. Contraindication & Precaution: Known hypersensitivity. Use in Pregnancy and Lactation: Recommended by the consultation with physician. fullness. Drug Interaction: No drug interactions have been reported. other gastrointestinal disturbances. Preparation: 67 mg/ml Paediatric Drops. Use in Pregnancy and Lactation: The regular use of NSAIDs during the last trimester of pregnancy may increase uterine tone and contraction.Close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function.6 ml . large dose of vitamin A may increase the risk of osteoporosis in postmenopausal women. large bowel preparation. muscle contraction. Flexilax® Active Ingredient: Baclofen. Drug Interaction: Lithium. Children (2-12 years) : 40 mg (0. It should not be prescribed during pregnancy. Preparation: 100 mg Tablet. spasticity resulting from Flexi TM Active Ingredient: Aceclofenac. Dermatological complaints including pruritus and rash and abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported. . abdominal pain. dizziness.88 Side Effect: Diarrhorea. Indication: Flexilax is indicated for the treatment of muscle spasm. unless there are compelling reasons for doing so.2 ml) 4 times daily. It should not be given to patients with moderate to severe renal impairment. Indication: Flatulence.3 ml) 4 times daily. skin may assume slightly yellow discoloration. The use of Aceclofenac should therefore be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus. abdominal distention. Preparation: Tablet. Contraindication & Precaution: Peptic ulcer or gastric-intestinal bleeding. Contraindication and Precaution: Do not exceed 12 doses per day without physician’s recommendation. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable Effects on the infant would be expected. Contraindication & Precaution: Baclofen is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product. Preparation: 50 mcg/spray. Side Effect: Nasal irritation & stinging. corporis. daytime sedation. Flugal ® F Active Ingredient: Fluconazole. The lowest dose compatible with an optimal response is recommended. oesophagitis. for 14-30 days in other mucosal infections (e. Tinea pedis.superficial candidal infections. treatment continued according to response. dryness of nose and throat. cryptococcal infections (including meningitis). cerebrovascular accidents or neoplastic or degenerative brain disease. Care must be taken while transferring patients from systemic steroid to Fluticasone nasal spray if there is any reason to suppose that their adrenal function is impaired.400 mg initially then 200 mg daily.g. Indication: Candidiasis. Contraindication and Precaution: Hypersensitivity to any of its components. Child over 1 year . spinal cord injuries and other spinal cord diseases. Dosage and Administration: Adults: 02 sprays in each nostril once daily. preferably . weakness and fatigue. Preparation: 5 mg & 10 mg Tablet 89 in the morning. Systemic candidiasis and cryptococcal infections (including meningitis) . candiduria). increased if necessary to 400 mg daily . Dosage & Administration: Acute or recurrent vaginal candidiasis . tension-type headache.a single dose of 150 mg. systemic candidiasis and cryptococcal infections Flonaspray® Active Ingredient: Propionate.Product Guide multiple sclerosis. Side-Effect: The most common advarse reactions associated with Baclofen are transient drowsiness. Nasal septum perforation. unpleasant taste & smell and epistaxis reported rarely. Use in Pregnancy & Lactation: Pregnancy category B. cruris. dizziness. versicolor and dermal candidiasis. Dosage & Administration: Flexilax (Baclofen) should be given in divided doses preferably 3 times daily for adults and 4 times daily for children. 1-2 mg/kg daily. Mucosal candidiasis (except vaginal): 50 mg daily (100 mg daily in unusually difficult infections) given for 7-14 days in oropharyngeal candidiasis . Fluticasone Indication: Prophylaxis and treatment of allergic rhinitis. muscle spasm of cerebral origin especially infantile cerebral palsy. Nasal Spray. The dosage shall be started from 5 mg three times a day to a maximum of 20 mg three times a day. Drug Interaction: None is yet known. Children (4 to 11 years of age) 01 spray in each nostril once daily. Drug Interaction: Rifampicin . Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed. administration should be discontinued.3-6 mg/kg daily (in serious life threatening infections up to 12 mg/kg daily has been given to children aged 5-13 years . Even if the prophylactic maintenance treatment is successful and well tolerated. rarely rash. up to 30 mg per day if required. Preparation: 200 mg. Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg). Contraindication & Precaution: Hypersensitivity. diarrhoea and flatulence.90 (including meningitis) . it should be interrupted after 6 months and it should be re-initiated only if the patient relapses.max. extrapyramidal . angioedema and anaphylaxis reported. phenytoin. warfarin. no significant improvement is observed. Flunarizine is not suited for aborting a migraine attack. Patients should be cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. especially in predisposed patients such as the elderly.abdominal discomfort. Dosage & Administration: Migraine Prophylaxis: Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. advanced liver disease. If. Indication: Flurizin is indicated for • Prophylaxis of classic (with aura) or common (without aura) migraine • Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system). The possible occurrence of an attack is therefore no reason to increase the dose of Flunarizine. after 2 months of this initial treatment. F Flurizin® Active Ingredient: Flunarizine. renal impairment.the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an addon therapy. Contraindication & Precaution: Hypersensitivity to Flunarizine. Flunarizine is contra-indicated in patients with a history of depressive illness. Side Effect:Nausea. children below the age of one year. 150 mg and 50 mg Capsule. Product Guide or other unacceptable symptoms occur. If. during this treatment depressive. or with pre-existing symptoms of Parkinson’s disease or other extrapyramidal disorders. the patient should be considered a nonresponder and administration should be discontinued. Peripheral Vascular disease: 10 mg twice daily. Use in Pregnancy and Lactation: Caution should be taken. 50 mg/5 ml Suspension. Flunarizine may lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. 400 mg daily). • Peripheral Vascular Disease (PVD) • Motion sickness • Refractory epilepsy resistant to conventional antiepileptic therapy. This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism. occasionally abnormalities of liver enzyme. skin irritation. nausea.g. Adapalene should not be applied to cuts. scaling. of which elderly patients seem particularly at risk. skin rash.Infrequently reported adverse reaction are: heartburn. Exercise caution when administering Adapalene to a nursing mother. burning sensation. ophthalmic. dryness. abrasions. Exercise particular caution in using preparations containing sulfur. . Fona Plus Gel is not for oral. tremor). Avoid exposure to sunlight and sunlamps.. forehead. Preparation: 5 mg & 10 mg Tablet. Side Effect: Erythema. Indication: Indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. anxiety.The following advarse experiences have been reported during chronic treatment with Flunarizine: depression. products with high concentrations of alcohol. soaps and cosmetics that have a strong drying Effect. Use in Pregnancy and Lactation: Safety in pregnancy and lactation has not been established. astringents. as well as weight gain and/or increased appetite may occur. stinging sunburn. each cheek). rigidity. extrapyramidal symptoms (such as bradykinesia. dry mouth. muscle ache. Side Effect: Drowsiness and/or fatigue. eczematous or sunburned skin. Dosage and Administration : Once daily at night-time. or intravaginal use. Use a pea-sized amount for each area of the face (e. Contraindication and Precaution: Hypersensitivity to Adapalene. akathisia. insomnia.Product Guide Flunarizine should therefore be used with caution in such patients. orofacial dyskinesia. Safety and effectiveness in children below 12 years of age have not been established. Drug Interaction: Concomitant use of other potentially irritating topical Active Ingredient: Adapalene & Benzoyl peroxide. Dosage & Administration: Apply a thin film of Fona Plus Gel to affected areas of the face and/or trunk once daily after washing. galactorrhoea. of which female patients with a history of depressive illness may be particularly at risk. gastralgia. Use in Pregnancy and Lactation: Use adapalene during pregnancy only if the potential benefit justifies the potential risk to the fetus. lips and mucous membranes. Contraindication & Precaution: Should not be administered to individuals who are hypersensitive to any of its component. 91 products (medicated or abrasive soaps and cleaners. pruritus. acne flares. chin. Avoid the eyes. Wear sunscreen when sun exposure cannot be avoided. Indication: Acne. resorcinol or salicylic acid in combination with Adapalene. Preparation: 10 gm Cream & Gel. spices or lime) should be approached with caution. F Fona Plus Gel TM Fona® Active Ingredient: Adapalene. and stinging/ burning may occur. Infections in immunocompromised patients. therefore. Preparation: 10 gm gel. pneumonia. especially with the use of peeling. Preparation: 1 gm IV Injection. Use in Children: Safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 12 years have not been established. Contraindication: Known allergy to the Cephalosporin antibiotics. pseudomembraneous colitis. Drug Interactions: Drug interactions have not been observed with Cefpirome. and skin irritation. Drug Interaction: Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy Effect may occur.i. contact dermatitis. scaling. or abrasive agents. vomiting. Severe urinary tract infections including pyelonephritis. Indication: 1. application site irritation. Use in Pregnancy & Lactation: There are no well-controlled trials in pregnant women treated with Adapalene and Benzoyl peroxide. As Cefpirome is excreted in human breast milk. Most commonly reported adverse events are dry skin. Side Effect: Diarrhea. Indication: Septicemia. Dosage and Administration: 1 gm b. F Frabex® Active Ingredient: Tranexamic acid. application site burning. Haemorrhage or risk of haemorrhage in increased fibrinolysis or fibrinogenolysis like • Prostatectomy and bladder surgery • Menorrhagia • Epistaxis • Conisation of the cervix • Management of dental extraction in patients with coagulopathies Force TM Active Ingredient: Cefpirome. especially during the early months of pregnancy. Skin and soft tissue infections. dryness. nausea. Furthermore. Bone and joint infections. abdominal pain. Pregnancy and Lactation: It should be administered with caution. Caution should be exercised when administered to a nursing woman. desquamating. bacteremia and infections in immunosuppressed neutropenic patients with hematological . this preparation should be used during pregnancy only if the potential benefit justifies the risk to the fetus. Superficial phlebitis.d. either Cefpirome treatment should be discontinued or breast feeding ceased.92 Side Effect: Erythema. Duration depends on response. such studies are not always predictive of human response. It is not known whether Adapalene or Benzoyl peroxide is excreted in human milk following use. maximum 4 gm daily by IV route only. Product Guide malignancies. thrombophlebitis and infection site reaction. No formal drug-drug interaction studies were conducted. Animal reproduction studies have not been conducted with the combination gel or Benzoyl peroxide. e. who require treatment with it must be under the strict supervision of a physician. General fibrinolysis as in prostatic and pancreatic cancer. Hereditary angioneurotic oedema. A second week of treatment may be indicated. stomatitis angularis. 3. mycoses secondarily infected with bacteria. pedis. such as deep vein thrombosis. otitis externa. candidiasis of skin and nails. Pityriasis versicolor. patients with disseminated intravascular coagulation (DIC).Product Guide 93 • Ulcerative colitis • Haematuria • Gastrointestinal haemorrhage 2. after thoracic and other major surgery. two to three times daily for 4-14 days Contraindication: . unguium or onychomycosis. Side Effect: Dose-dependent. manuum. Active thromboembolic disease. Dosage & Administration: Twice daily. Dosage & Administration: 1 tablet daily (apply in the morning) for 7 days. The use of Miconazole in children below the age of 7 is not . barbae. once daily. Side Effect: Topical application of Miconazole Nitrate has almost no side Effect. F Fungidal BT ® Active Ingredient: Miconazole Nitrate. Hypersensitivity to tranexamic acid or any of the ingredients Precautions: irregular menstrual bleeding. Miconazole should be applied to the gingiva in the morning. above the eye tooth. cruris. Fungidal ® Active Ingredient: Miconazole Nitrate. for one week. Use in Pregnancy & Lactation: Can be used. Indication: Skin and nail infections due to dermatophytes. Dosage & Administration: 2-3 (500 mg) capsules or 5-10 ml by slow intravenous injection at a rate of 1 ml/ minute. usually well tolerated. high risk of thrombosis. in obstetrical complications such as abruptio placentae and postpartum haemorrhage. Contraindication & Precaution: No contraindication is known. pulmonary embolism and cerebral thrombosis . corporis. Preparation: 20 mg/gm Cream. i. in leukaemia and liver diseases and in connection with thrombolytic therapy with streptokinase. Subarachnoid haemorrhage . Use in Children: Can be used. Do not swallow.yeasts and other fungi such as: Tinea capitis. Preparation: 500 mg Capsule & 5 ml ampoule of 500 mg IV Injection. Use in Pregnancy and Lactation: Miconazole Nitrate should be used with caution during pregnancy. Indication: For the treatment and prevention of Oropharyngeal & Esophageal Candidiasis. 20 mg daily or 40 mg on alternate days. vomiting.94 recommended. Preparation: (20 mg +10 mg)/gm Cream. Contraindication & Precaution:Known hypersensitivity to Miconazole Nitrate or to any of the other ingredients of the product. hepatic and renal oedema. Corticosteroids can be absorbed. Caution should be exercised when prescribing to pregnant women. Injection : 20-50 mg/day IM/IV. pulmonary. Fungidal-HC ® Active Ingredient: Miconazole Nitrate and Hydrocortisone.1 to 3 mg/kg/day. Children. max. Lactation: No adequate data on excretion of Miconazole Nitrate in human milk are available. it should be used immediately. Children. In cases of reduced salivary production. acne. F Side Effect: Nausea and taste perversion are common side effects experienced with Miconazole buccal tablet. primary irritant or contact allergic eczema or seborrheic eczema. Preparation: 10 mg Buccal Tablet. Side Effect: Local sensitivity may occur. Dosage and Administration: Tablet : In mild cases. Use in Pregnancy and Lactation: Topical steroids should not be extensively used in pregnancy. peripheral oedema and hypertension. Fusid ® Active Ingredient: Furosemide.0. max. reapplication of a new tablet may be required. Dosage & Administration: Two or three times daily. . Harmful Effects are not expected following accidental ingestion of the Miconazole buccal tablet. Contraindication & Precaution: Hypersensitivity. It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Use in Pregnancy & Lactation: Pregnancy: There are no adequate data from the use of Miconazole Nitrate in pregnant women. Contraindication & Precaution: Anuria. perianal and genital dermatitis. 20 mg/ day. Indication: Cardiac. can produce systemic Effects. In resistant cases. Caution should be exercised when prescribing to breastfeeding women. Allergic reaction is rarely observed.5 mg/kg/day. Method of Administration: Once a tablet is removed from the blister. Product Guide Indication: Inflamed dermatoses such as intertrigo and infected eczema. A minimal salivary production is required to guarantee complete disintegration of the tablet and release of the active drug substance. Drug Interaction: Amphotericin antagonises Effect of miconazole. However.5-1. 80 mg/ day. 40 mg/day. tablet erosion may be prolonged or inhibited. Mouth irritation. oral numbness. diarrhoea & dizziness are uncommon side effects. Preparation: 40 mg Tablet and 20 mg/2 ml Injection. uric acid retention and may rarely produce acute gout. Indication: Essential hypertension. menstrual irregularities. Use in Pregnancy and Lactation: Fusid should be cautiously used in cardiogenic shock complicated by pulmonary oedema and in the first trimester of pregnancy. hyponatremia. sucralfate. furosemide or sulphonamides. cardiac arrhythmias.Chronic congestive heart failure. 95 deteriorating or severe impairment of renal function (creatinine clearance: < 30 ml/min). (Spironolactone 50 mg and Furosemide 40 mg)/ Tablet. hirsutism. acute renal insufficiency. hyperkalaemia. Caution should be taken in patients liable to electrolyte deficiency. Furosemide is excreted in breast milk and breast-feeding should be discontinued if treatment is essential. resistant edema associated with secondary hyperaldosteronism. F Fusid Plus Active Ingredient: Spironolactone + Furosemide. an alternative method of infant feeding should be instituted. Addison’s disease. Drug Interaction: ACE inhibitors. skin rashes. Should be used with caution during lactation. mental confusion. Contraindication and Precaution: Anuria. Preparation: (Spironolactone 50 mg and Furosemide 20 mg)/ Tablet. deepening of the voice. ataxia. Swelling due to excess fluid retention (edema). Fusid 40 plus: one to two tablets daily. potassium salts. Side Effect: Alkalosis. and in patients who are hypersensitive to spironolactone. Blood pressure and pulse during rapid diuresis should be monitored. Hypersensitivity to furosemide or sulphonamides. hypotension and in hypovolemia. indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs). corticosteroids. Hyperaldosteronism. dehydration and reduction in blood volume with circulatory collapse. Dosage and Administration: Fusid plus: 1 to 4 tablets daily. Side Effect: Headache and drowsiness. rapidly ® . cardiac glycosides. The toxic Effects of nephrotoxic antibiotics may be increased by concomitant administration of potent diuretics such as furosemide. Use in Pregnancy: Furosemide should only be used in women in child bearing age when appropriate contraceptive measures are taken or if the potential benefits justify the potential risks to the foetus. enlarged prostate. Used with caution in diabetes. Fusid may provoke hyperglycemia and glycosuria.Product Guide electrolyte deficiency and pre-comatose states associated with liver cirrhosis. impotence. hyperkalemia. gynaecomastia. Hepatic cirrhosis with ascites. gastrointestinal distress including cramp and diarrhoea. Use in Lactation: If use of Spironolactone is considered essential. aminoglycoside antibiotics. lithium. Drug Interaction: ACE inhibitors. the Effective dose of Gabastar® is 900 to 1800 mg/day given in three divided doses. astemizole. G Contraindication & Precaution: Known hypersensitivity to the active drug. oral . Contraindication & Precaution: Gabapentin is contraindicated in patients who have known hypersensitivity to the drug. If the concomitant use of Miconazole and anticoagulants is envisaged. dry mouth and somnolence may occur. Epilepsy: Patients over 12 years of age . Drug Interaction: Terfenadine. Patients should not drive a car or operate complex machinery until they have gained sufficient experiences about Gabapentin whether or not it affects their mental and/ or motor performance adversely. Children aged 2-6 years: One tea-spoonful of gel twice daily . cisapride. than 300 mg twice on Day-2 and 300 mg thrice on Day-3. Adjunctive therapy in partial seizure and secondary generalized seizure Dosage & Administration: Neuropathic Pain: The treatment may be initiated as a single 300 mg dose on Day-1. if they are used concomitantly. mizolastine. Syrup. Paediatric patients age 3-12 years. The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID). it should be used during pregnancy only if potential benefits justifies the potential risk to the fetus. Neuropathic Pain . Gabastar® Active Ingredient: Gabapentin. Preparation: 100 mg. caution is required to ensure that the gel does not obstruct the throat. It is advisable to monitor Miconazole and phenytoin levels. allergic reactions. and the Effective dose reached by upward titration over a period of approximately three days. peripheral edema. In case of renal impaired patients Gabapentin doses must be reduced. and of super infections due to Gram-positive bacteria. ataxia.96 Product Guide category C. Children aged 6 years and over: One teaspoonful of gel four times daily. Use in Pregnancy & Lactation: Pregnancy Gelora® Active Ingredient: Miconazole. triazolam. Dizziness. weight gain. 300 mg. Infants under 2 years : Half teaspoonful of gel twice daily. 600 mg Tablet. Indication: Gabastar (Gabapentin) is indicated for . vomiting. the anti-coagulant Effect should be carefully monitored and titrated. Particularly in infants and young children. Adverse Effects: Nausea. Side Effect: Fatigue. Gabapentin may be secreted through the breast milk. diarrhoea. Gabapentin can be taken orally with or without food. So it should be used during lactation only if potential benefits justifies the potential risk to the baby. The starting dose is 300 mg three times a day. Dosage and Administration: Adults : 1-2 teaspoonfuls of gel four times daily. Indication: Treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract.the starting dose should range from 10-15 mg/ kg/day in 3 divided doses. acute meibomianitis. endocarditis. Caution should be exercised when prescribing Miconazole Oral Gel to nursing mothers. conjunctival epithelial defects. Preparation: 20 mg/2 ml Injection. skin tingling. in divided doses every 8 hours or as directed by the physician. Dosage & Administration: 2-5 mg/kg body wt. Ear: 2-3 drops every 3-4 times a day or frequently. Preparation: 3% Eye/Ear Drops. It should never be injected subconjunctivally. blepharoconjunctivitis. Frusemide and piretanide may potentiate the ototoxicity of gentamicin and ethacrynic acid. auditory ototoxicity may occur. muscle twitching. reversible nephrotoxicity. keratitis. swelling.and conjunctival hyperemia. 97 Genacyn® Injection Active Ingredient: Gentamicin. redness. Dosage & Administration: 1-2 drops in affected eye 6 times a day or frequently. G . acute pyelonephritis or prostatitis. simvastatin and lovastatin. quinidine. Symptoms are dizziness. daily. pimozide. nor directly introduced into the anterior chamber of the eye. keratoconjunctivitis. external otitis. biliary tract infection. renal failure. dacryocystitis. Drug Interaction: Concurrent use with other potentially nephrotoxic or ototoxic drug substances should be avoided. Contraindication & Precaution: Hypersensitivity. Use in Pregnancy and Lactation: Miconazole Oral Gel should be avoided in pregnant women if possible. roaring in the ears. The potential hazards should be balanced against the possible benefits. conjunctivitis. dofetilide. including fungi.Product Guide midazolam. vertigo. Side Effect: Irritation. Preparation: 20 mg/gram Oral Gel. convulsions. tinnitus. meningitis and other CNS infection. chronic suppurative otitis media. 80 mg/2 ml Injection. Use in Pregnancy and Lactation: Should be administered when considered essential. corneal ulcers. myasthenia gravis. Indication: Blepharitis. Also numbness. rarely hearing loss. ocular burning and irritation upon drug instillation. Use in Pregnancy and Lactation: Gentamicin should only be used where the seriousness of the mother’s condition justifies the risk. should be avoided with gentamicin. Indication: Septicaemia and neonatal sepsis. which is ototoxic in its own right. Contraindication & Precaution: Hypersensitivity. itching. non-specific conjunctivitis. Side Effect: Vestibular damage. Genacyn® Eye/Ear Drops Active Ingredient: Gentamicin. overgrowth of nonsusceptible organisms. Dosage & Administration: Apply 3-4 times daily. fungal or viral superinfection. hepatic or renal dysfunction. myasthenia gravis •Status asthmaticus Side Effect: Adverse reactions include respiratory depression. stasis ulcers and infected skin ulcers. Child: 2-7 mg/kg body weight. furunculosis. minor surgical wounds.5% (25 mg/ml) solution. redness.1% Ointment. infected contact dermatitis caused by susceptible organisms. eczema. ecthyma. increased blood urea. Preparation: 0. seborrheic dermatitis. pyoderma gangrenosum. Indication: Genisia is used for the following cases: may be prolonged or potentiated¬ excessive premedication. skin cysts and abscesses. The treated area may be covered with gauze dressing if desired. swelling or other signs of irritation.5-3 mg/kg may be given to reduce intraoperative elevations of intracranial pressure (repeated as required). Indication: Burns. sycosis barbae. bacterial. If crusts present. 500 mg). Precaution: It should not be used to patients with hypersensitivity to Gentamicin. asthma. insect bites and stings. lacerations and abrasions. 75-125 mg as a single dose. Before application the area should be washed with soap and water and dried thoroughly.5% (25 mg/kg) solution. initially 100150 mg over 10-15 seconds. paronychia. myxedema. myocardial • Induction of general anesthesia • Anesthesia of short duration . folliculitis. severe anemia. followed by further quantity if necessary according to response after 30-60 seconds up to 4 mg/ kg (max.98 Product Guide Genacyn® Ointment Active Ingredient: Gentamicin. Raised intracranial pressure: By intravenous injection 1. • Reduction of raised intracranial pressure if ventilation controlled • Status epilepticus Dosage & Administration: Induction of general anesthesia: Adults: By intravenous injection usually as a 2. it should be removed before application of ointment to provide maximum contact with the infecting organisms. Contraindication & Precaution: Absolute Contraindication: G • Absence of suitable veins for intravenous administration acute intermittent porphyria Relative Contraindication • Hypersensitivity (allergy) to barbiturates • Variegate porphyria (South African) or Genisia TM • Severe cardiovascular disease • Hypotension or shock • Conditions in which the hypnotic Effect Active Ingredient: Thiopental Sodium. excoriation. Status epilepticus (only if other measures fail): by intravenous injection as a 2. Addison’s disease. Side Effect: Itching. urticaria. immune hemolytic anemia with renal failure and radial nerve palsy have been reported. For disinfection of the patients’ skin prior to surgery or other invasive procedures. Drug Effect Probenecid Prolonged action of Thiopental Diazoxide Hypotension Zimelidine Thiopental antagonism Opioid analgesics Decreased anti nociceptive action Aminophylline Thiopental antagonism Midazolam Synergism Use in Pregnancy & Lactation: Pregnancy Category C. laryngospasm and shivering. Gluconate 99 Uses:For the disinfection of clean and intact skin. vasodilation and edema should be managed by conventional means. Thiopental should be given to a pregnant woman only if clearly needed. When dry apply a further 5 ml and repeat the procedure. For pre-operative surgical hand disinfection. Do not use in body cavities. Dosage & Administration: For external use only. The solution is irritant to the eyes and mucous membranes. e. sneezing. hand disinfection on the ward prior to aseptic procedures or after handling contaminated materials. Animal reproduction studies have not been conducted with Thiopental. Keep out of eyes. Rarely. prolonged somnolence and recovery. Antiseptic hand disinfection on the ward: Dispense 3 ml of solution and spread thoroughly over the hands and wrists rubbing vigorously until dry. cardiac arrhythmias. Adults: Pre-operative surgical hand disinfection: Dispense 5 ml of solution and spread thoroughly over both hands and forearms. coughing. If chlorhexidine solutions come into contact with the eyes.. bronchospasm. Symptoms. Contraindication & Precaution: Chlorhexidine Gluconate is contraindicated for persons who have previously shown a hypersensitivity to Chlorhexidine. rubbing vigorously. Not for injection. It is also not known whether Thiopental can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. bronchospasm. Thiopental sodium readily crosses the placental barrier and small amounts may appear in the milk of nursing mothers following administration of large doses. meninges or middle ear. Elderly and children: There are no special dosing regimes for children and the elderly.Product Guide depression. Drug Interaction: The following drug interactions have been reported with Thiopental. Anaphylactic and anaphylactoid reactions to Thiopental Sodium have been reported. Flammable - G Germisol Active ® Hand Rub Chlorhexidine Ingredient: . Avoid contact with the brain.g. Chlorhexidine Gluconate is also used for preparation of the skin prior to invasive procedures such as venepuncture. such reactions are extremely rare. wash out promptly and thoroughly with water. However. Disinfection of patients’ skin: Prior to surgery apply the solution to a sterile swab and rub vigorously over the operation site for a minimum of 2 minutes. Preparation: Each vial contains Thiopental Sodium USP 500 mg. For patients inadequately controlled on sulfonylurea monotherapy or who have initially responded to Rosiglitazone alone and require additional . Generalised allergic reactions have also been reported but are extremely rare. Product Guide must be determined individually. Use in Pregnancy & Lactation: Specially designed for pregnancy. Contraindication & Precaution: Hypersensitivity. A double dose is not recommended. Glimepiride and Indication : Type 2 diabetes mellitus. • Threatened abortion • Habitual abortion • Threatened premature delivery Dosage & administration: Threatened abortion: 1 tablet three times daily until symptoms disappear. High dosages (up to 40mg daily) have been used. Side Effect: Treatment with Allylestrenol (especially a long term treatment with it) is known to cause some gastrointestinal complaints such as vomiting. hormone-dependent carcinoma.2 tablets daily as soon as pregnancy is diagnosed. allow drying before proceeding. Side Effect: Irritative skin reactions can occasionally occur. Dosage and Administration: Glyros should be given once daily with the meal of the day. Should not be used during lactation.5% w/v Chlorhexidine Gluconate in 70% v/v Isopropyl Alcohol. severe hepatic impairment. thrombophleobitis.incomplete abortion. Prolonged skin contact with alcoholic solutions should be avoided. The administration should be continued for at least one month after the end of the critical period. as a diagnostic test for pregnancy. Hypochlorite bleaches may cause brown stains to develop in fabrics which have previously been in contact with chlorhexidine solutions. Threatened premature delivery : Dosage Glyros® Active Ingredient: Rosiglitazone.100 this preparation contains alcohol:when use is to be followed by diathermy do not allow pooling of the fluid to occur. Preparation: 5 mg tablet. nausea. Missed dose: In case of a missed dose it should be taken as soon as the patient remembers & she should continue the regular dosing schedule. undiagnosed vaginal bleeding. Use in Children: It should not be used for children younger than 16 years old. and sometimes epigastric discomfort. Geston Indication: TM Active Ingredient: Allylestrenol. and ensure that the skin and surrounding drapes are dry. Drug Interaction: Chlorhexidine is incompatible with soaps and other anionic agents. G Use in Pregnancy & Lactation: No untoward Effects are known. Preparation: 0. Habitual abortion : 1 . cerebral apoplexy. Neomycin Sulphate. asthenia. and morbilliform or maculopapular eruptions. diclofenac. Preparation: Each box contains 2 x 6 vaginal suppositories. Drug interactions: Glimepiride: Thiazides and other diuretics. Combination of Glimepiride or Rosiglitazone should not be used during pregnancy. Preparation: (Glimepiride 1 mg and 101 Rosiglitazone 4 mg)/Tablet. phenothiazines. thyroid products.. oral hypoglycemic agents. Caution should be taken in case of renal impairment. injury. Nystatin. When switching from combination therapy of Glimepiride plus Rosiglitazone as separate tablets. nausea. and isoniazid. the usual starting dose of Glyros is 1 mg/4mg or 2 mg/4 mg once daily. oral miconazole. Dosage & Administration: One suppository in vagina at bedtime for 12 days. anemia. ibuprofen. the usual starting dose of Glyros is the dose of Glimepiride and Rosiglitazone already being taken. corticosteroids. urticaria may occur rarely. H Halobet TM Active Ingredient: HalobetasolPropionate. Gynepro® Active Ingredient: Metronidazole. sympathomimetics.g. erythema. phenytoin. Adverse Effects: Glimepiride: Hypoglycemia. e.headache. Side Effect: Skin rash. Nursing mothers: Combination of Glimepiride or Rosiglitazone should not be administered to a nursing woman. Allergic skin reactions. naproxen. Use in Pregnancy and Lactation: Caution should be practiced in pregnancy and lactation. or as directed by the physician. Indication: Vaginal trichomoniasis. Diabetic ketoacidosis. Sufficient time should be given to assess adequacy of therapeutic response. Rosiglitazone: Upper respiratory tract infection. mixed vaginal infections (Fungal or Bacterial). pruritus. rifampin. estrogens. Use in Pregnancy: Category C. Polymyxin B Sulphate. dizziness. Contraindications : Known hypersensitivity to Glimepiride or Rosiglitazone or any of the components of combination of Glimepiride or Rosiglitazone. edema’ Angioedema and urticaria. headache. with or without coma. urticaria. phenytoin. and mefenamic acid. Polymyxin B Sulphate and Nystatin. oral contraceptives. The maximum recommended daily dose of Glyros is 4 mg of Glimepiride and 8 mg of Rosiglitazone. Indication: Halobet (Halobetasol Propionate) cream & ointment are a superhigh potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid- . (Glimepiride 2 mg and Rosiglitazone 4 mg)/Tablet. nicotinic acid.Product Guide glycemic control. Neomycin Sulphate. Contraindication & Precaution: Contraindicated to the patients who are hypersensitive to Metronidazole.Rosiglitazone:gemfibrozil.vaginal leucorrhoeas. These reactions are listed in an approximate decreasing order of occurrence: foluliculitis. Dosage & administration: Apply a thin layer to the affected skin once or twice daily. Halobet(Halobetasol Propionate) is a super-high potency topical corticosteroid. erythema. striae and miliaria. acneiform eruptions. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. and they may occur more frequently with high potency corticosteroids. burning or itching in 4. hypertrichosis.There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. allergic contact dermatitis. or to substitute a less potent steroid. skin atrophy. Contraindication & Precaution: Halobetasol Propionate is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. requiring supplemental systemic corticosteroids. hyperglycemia. leukoderma. or for prolonged periods of time. reassessment of diagnosis may be necessary. Conditions which augment systemic absorption include the application of the more potent steroids. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. signs and symptoms of steroid withdrawal may occur. Therefore. The following additional local adverse reactions are reported infrequently with topical corticosteroids.4% of the patients. to reduce the frequency of application. therefore. and the addition of occlusive dressings. such as Halobet. the most frequent adverse events reported for Halobet included stinging. as directed by your physician and rub in gently and completely. caution H . patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. Less frequently reported adverse reactions were dry skin.hypopigmentation. Drugs of this class should not be used extensively on pregnant patients. Infrequently. Drug Interaction: No such report has been founded. Product Guide Side Effect: In controlled clinical trials. and glucosuria in some patients. Halobet should not be used with occlusive dressings. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. vesicles and rash. If no improvement is seen within 2 weeks. perioral dermatitis.102 responsive dermatoses. an attempt should be made to withdraw the drug. Therefore. Use in Pregnancy & Lactation: Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. use over large surface areas. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. prolonged use. seconday infection. manifestations of Cushing’s syndrome. Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression. Nevertheless. treatment should be discontinued when control is achieved. in large amounts. topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. If HPA axis suppression is noted. Precaution: Hemorif ® Active Ingredient: Micronised Diosmin and Hesperidin Indication: Acute hemorrhoidal attacks. diarrhea. 103 Hepavir® Active Ingredient: Lamivudine. Drug Interaction: sulfamethoxazole. Side Effect: Gastric disorder and neurovegetative disorders (feeling of discomfort). Chronic hemorrhoids : 1 tablet twice daily. pain. myalgia. pain. sore throat. nausea. Indication: Treatment of HIV infection. Use in Children: Not recommended for use in children. post treatment exacerbations of hepatitis B. ENT infections. headache. Indication: Chronic hepatitis B with evidence of hepatitis B viral replication and active liver inflammation.05% Cream . Preparation: (450 mg + 50 mg)/Tablet. vomiting. fatigue.05% Ointment .Each pack has a laminated tube containing 10 gm cream. Side Effect: Lactic acidosis and severe hepatomegaly with steatosis. Contraindication and Known hypersensitivity. Halobet 0. Hivarif® Active Ingredient: Lamivudine.Product Guide should be exercised when topical corticosteroids are administered to a nursing woman. Preparation: 100 mg Tablets.Organic and functional chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs. and emergence of viral mutants Malaise. skin rashes may occur. Chronic hemorrhoidal disease. Preparation: Halobet 0. abdominal discomfort. Chronic venous insufficiency : 1 tablet twice daily initially for seven days. nocturnal cramps. Dosage and Administration: Acute hemorrhoidal attacks: 3 tablets twice daily for 4 days. Mothers should be instructed not to breast feed if they are receiving lamivudine. fever. Duration may be increased depending on severity. arthralgia. Dosage and Administration: 100 mg once daily. pancreatitis. then 2 tablets twice daily for three days and if required then 1 tablet twice daily.Each pack has a laminated tube containing 10 gm ointment. Trimethoprim / H Use in Pregnancy and Lactation: Lamivudine should be used during pregnancy only if the potential benefits outweigh the risks. Dosage and Administration: Adults and adolescents over 12 years of age : 300 mg . a history of pancreatitis. nausea. Lactic acidosis and severe hepatomegaly with steatosis. Indication: Acute and chronic diarrhoea. Allergic States. including Lamivudine and other antiretrovirals. fever. The fraction of loperamide secreted in the human milk is very low.104 daily. In patients with moderate to severe renal impairment. Collagen Diseases. abdominal cramps and bloating urticaria. tiredness. however should not exceed 8 capsules for adults. I Inflagic® Active Ingredient: Prednisolone. Use in Pregnancy & Lactation: Although studies in animal did not demonstrate any teratogenic Effect of loperamide. Contraindication & Precaution: It should not be used in children less than 4 years of age. rises in serum amylase. Dosage and Administration: Acute diarrhoea: The initial dose is 2 capsules for adults and 1 capsule for children older than eight. Drug Interaction: Trimethoprim/ sulfamethoxazole and zalcitabine. in addition 1 capsule should be taken at any subsequent loose stool. The safety of Lamivudine in human pregnancy has not been established. Chronic diarrhoea Initial dose: Adults: 2 capsules daily. pancreatitis. including fatal cases. Dermatologic Diseases. Children : Three months to 12 years of age: 4 mg/kg twice daily up to a maximum of 300 mg daily. transient rises in liver enzymes (AST. IBS (Diarrhoea predominant). Contraindication & Precaution: Hypersensitivity to Lamivudine or to any of the excipients. Particular caution should be exercised when administering Lamivudine to any patient with known risk factors for liver disease. the dose should be adjusted. alopecia. insomnia. Preparation: 150 mg Tablet & 10 mg/ml Oral Solution (100 ml). Rheumatic disorders. have been reported with the use of nucleoside analogues alone or in combination. muscle disorders. rash. diarrhea. cough. headache. abdominal pain or cramps. nasal symptoms. drowsiness. Preparation: 2 mg Capsule. peripheral neuropathy (or paraesthesia). It is recommended that mothers taking Lamivudine do not breastfeed their infants. fatigue. or other significant risk factors for the development of pancreatitis. Children: Older than eight: 1 capsule daily. but caution is advised if it is to be administered to nursing mothers. . Use in Pregnancy and Lactation: Pregnancy Category C. Side Effect: Neutropenia. This is administered as 150 mg twice daily. Lamivudin is not recommended for use as monotherapy. malaise. nausea. Lamivudine should be used with caution. hepatitis. The daily dose. Indication: Endocrine Disorders. Side Effect: Paralytic ileus. arthralgia. vomiting. for children 4-6 capsules according to age. vomiting. ALT). constipation. it should not be administered during pregnancy. In pediatric patients with a history of prior antiretroviral nucleoside exposure. dizziness and dry mouth. Product Guide Imotil ® Active Ingredient: Loperamide. it is recommended that it should be withdrawn gradually rather than abruptly. Contraindication & Precaution: Systemic fungal infections and known hypersensitivity to components. Aseptic necrosis of femoral and humeral heads. Gastrointestinal Diseases Dosage & Administration: The initial dose may vary from 5 mg to 60 mg per day depending on the specific disease. Convulsions Vertigo. Gastrointestinal: Peptic ulcer with possible perforation and hemorrhage. Fluid retention. Steroid myopathy. I . particularly in times of stress. and may suppress reactions to skin tests. Pathologic fracture of long bones. Decreased carbohydrate tolerance. Neurological: Increased intracranial pressure with papilledema. Suppression of growth in children. Loss of muscle mass. Ophthalmic: Posterior subcapsular cataracts. as in trauma. particularly of the Achilles tendon. Respiratory Diseases. should be carefully observed for signs of hypoadrenalism. Endocrine: Menstrual irregularities. Hypokalemic alkalosis. aspartate transaminase (AST. Glaucoma. Increased requirements for insulin or oral hypoglycemic agentsin diabetics. Manifestations of latent diabetes mellitus. If after long-term therapy the drug is to be stopped. Edematous States. thin fragile skin. Ulcerative esophagitis. Metabolic: Negative nitrogen balance due to protein catabolism. the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. increased sweating. Multiple Sclerosis: In the treatment of acute exacerbations of multiple sclerosis daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be Effective. 105 SGOT) and alkalinephosphatase have been observed following corticosteroid treatment. nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus.Petechiae and ecchymoses. Neoplastic Diseases. anaphylactic or hypersensitivity reactions. Osteoporosis.Product Guide Ophthalmic Diseases. (pseudo-tumor cerebri) usually after treatment. After a favorable response is noted. Infants born of mothers. Use in Pregnancy & Lactation: Since adequate human reproduction studies have not been done with corticosteroids. Congestive heart failure in susceptible patients. Musculoskeletal: Muscle weakness. Side Effect: Fluid and Electrolyte Disturbance: Sodium retention. Additional Reactions: Urticaria and other allergic. Abdominal distention. SGPT). who have received substantial doses of corticosteroids during pregnancy. Headache. Secondary adrenocortical and pituitary unresponsiveness. Hematologic Disorders.These changes are usually small. Dermatologic: Impaired wound healing. surgery or illness. Exophthalmos. Vertebral compression fractures. Hypertension. not associated with any clinical syndrome and are reversible upon discontinuation. Facial erythema. Development of Cushingoid state. the use of these drugs in pregnancy. Constant monitoring is needed in regard to drug dosage. All corticosteroids increase calcium excretion. Pancreatitis. Potassium loss. Dietary salt restriction and potassium supplementation may be necessary. increased intraocular pressure. Tendon rupture. Increases in alanine transaminase (ALT. nervousness. Preparation: 20 mcg/puff. angio-oedema of tongue.0-4. Indication: Asthma and Chronic Obstructive Pulmonary Diseases including chronic bronchitis and emphysema. nausea.blurred vision/ difficulty in accommodation & drying of secretions. Ipratropium bromide should be used during pregnancy only if clearly needed. Dosage & Administration: Adults . Side Effect: dry mouth through inhibition of salivary flow. Less frequently tachycardia. Iprex TM Inhaler Active Ingredient: Ipratropium. nervousness..0. alopecia.nausea. tachycardia. known or suspected cases of hypersensitivity to ipratropium bromide. flushing.The same mode of administration is applicable to children. drowsiness. dizziness. Children: 1-2 puffs 2-3 times daily. exacerbation of symptoms. Allergic-type reactions such as skin rash.4-2 ml (100-500 mcg) of Ipratropium bromide should be diluted to a final volume of 2.or to atropine and its derivatives. itching. Product Guide four times daily. headache. hypotension. co-ordination difficulty. constipation. paresthesias. constipation. itching. It is not known whether ipratropium bromide is excreted in human milk. Use in Pregnancy & Lactation: Pregnancy Category B.4-2 ml of the prepared solution administered 3 times daily. & imitation from aerosol. prostatic hypertrophy or bladder-neck obstruction. oropharynx. hives. Indication: Maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease. & irritation from aerosol. blurred vision/difficulty in accommodation & drying of secretions. acute eye pain. I Side Effect: Dryness of the mouth. tremor & mucosal ulceration. Dosage & Administration: Adults :1-2 puffs (20 mg/puff ) 3-4 times daily. worsening of narrow-angle glaucoma. cough. coordination difficulty. tremor & mucosal ulceration. Contraindication & Precaution: Contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean and peanut. Children (over 3 years) . dryness of the oropharynx. Preparation: 250 mcg/ml Respirator Solution. headache. flushing.9% administered . paresthesias. Contraindication & Precaution: Known hypersensitivity. laryngospasm and anaphylactic reaction. lips & face. drowsiness. 200 puffs. Drug Interaction: There are no studies fully evaluating the interaction Effects of Ipratropium. Iprex TM Respirator Solution Active Ingredient: Ipratropium. including chronic bronchitis and emphysema. alopecia.0 ml with normal saline 0. exacerbation of symptoms.106 Preparation: 5 mg & 20 mg tablet. urticaria (including giant urticaria). 0. Ipratropium bromide should be used with caution in patients with narrow-angle glaucoma. cough.dizziness. or to any other component of the product. Children 0 – 5 years of age (for treatment of acute asthma only): 125 – 250 micrograms (i. Indication: Antiulcerant Indication: Indicated for reducing the risk of NSAID (nonsteroidal anti-inflammatory drugs. Daily doses exceeding 2 mg in adults and children over 12 years of age should only be given under medical supervision. Mydriasis.Dizziness. Uncommon: Urticaria. 1ml) up to a total daily dose of 1mg (4 ml).e. when used concomitantly with inhaled beta2agonists. 500 micrograms. Contraindication & Precaution: Known hypersensitivity to atropine or its derivatives. It is recommended that the nebuliser solution is administered via a I Isovent TM Active Ingredient: Misoprostol. 1 ml or 2 ml) 3 to 4 times daily. Vomiting. Pruritus.e. For treatment of acute bronchospasm. Skin rash. Dosage & Administration: Adults (including the elderly) and children over 12 years of age:250 . eg. Atrial fibrillation. If mouthpiece is not available and a nebuliser mask is used. Tachycardia. Preparation: 500 mcg/2 ml. 0. Care must be taken not to allow the solution or mist to enter the eyes. Use in Pregnancy & Lactation: The benefits of using Ipratropium Nebuliser Solution during pregnancy must be weighed against the possible hazards to the fetus.e. Ipratropium bromide should be administered no more frequently than 6 hourly in children under 5 years of age. Intraocular pressure increased. Indication: It is indicated for treatment of reversible bronchospasm associated with chronic obstructive pulmonary disease (COPD). Caution should be exercised when Ipratropium Nebuliser Solution is administered to nursing mothers. Patients must be instructed in the correct administration of Ipratropium Nebuliser Solution. it must fit properly. Inhalation induced bronchospasm. including aspirin)-induced gastric ulcers in patients at high risk of complications from gastric ulcer. Nausea. It is advisable not to exceed the recommended daily dose during either acute or maintenance treatment. for treatment of reversible airways obstruction as in acute and chronic asthma. Dryness of mouth. such as patients with a history of ulcer.12 years of age: 250 micrograms (i. Children 6 .5 ml – 1 ml) up to a total daily dose of 1 mg (4 ml).Product Guide 107 mouthpiece. Iprex TM Nebuliser Solution Active Ingredient: Ipratropium. It is not known whether ipratropium bromide is excreted into breast milk. the elderly and patients with concomitant debilitating disease. Palpitations. The time interval between doses may be determined by the physician. Gynecological Indication: Labor induction (in unfavorable cervical conditions) & in the prevention & treatment of Post Partum . Rare: Anaphylactic reaction.500 micrograms (i. Cough. as well as patients at high risk of developing gastric ulceration.It is also indicated. Side Effect: Common:Headache. Eye pain. Preparation: 100 mcg. Gynecological dosage & administration: Induction of Labor: 25 mcg vaginally 6 hourly or. tinea. pulmonary and CNS drugs and NSAIDs. raised liver enzymes. Drug Interaction: No evidence of clinically significant interaction between Misoprostol and cardiac.g. urticaria and angioedema). Side Effect: Gastrointestinal: Abdominal pain. in AIDS patients to prevent relapse of underlying fungal infections and in the prevention of fungal infection during prolonged neutropenia. Misoprostol should be taken for the duration of NSAID therapy as prescribed by the physician. Dosage and Administration: 100 mg -200 mg daily. 200 mcg & 600 mcg Tablet. Bioavailability of Misoprostol is decreased with high doses of antacid. cryptococcosis. 200 mcg orally with 400 mcg sublingually. Indication: Candidiasis. Side Effect: Nausea. I Itra® Active Ingredient: Itraconazole. It should not be used in women of childbearing potential unless the patient requires nonsteroidal anti-inflammatory drug (NSAID) therapy and is at high risk of developing gastric or duodenal ulceration or for developing complications from gastric or duodenal ulcers associated with the use of the NSAID. On . constipation. peripheral neuropathy and StevensJohnson syndrome reported. Because of the potential for serious adverse reactions in nursing infants. hepatitis and cholestatic jaundice. Contraindication and Precaution: Misoprostol should not be taken by pregnant women to reduce the risk of ulcers induced by nonsteroidal antiinflammatory drugs (NSAIDs). menstrual disorder and dysmenorrhea. it is not recommended for use by nursing mothers. Postpartum Hemorrhage (PPH) prophylaxis: 400 mcg to 600 mcg orally or rectally immediately following delivery of the child. pityriasis versicolor. rash. headache. Misoprostol should not be taken by anyone with a history of allergy to prostaglandins. menstrual disorders. 50 mcg orally 4 hourly. Postmenopausal vaginal bleeding may be related to Misoprostol administration. dizziness. aspergillosis. histoplasmosis.108 Hemorrhage (PPH) Dosage & Administration: Antiulcerant Dosage & Administration: 200 mcg four times daily with food. Product Guide Use in Pregnancy & Lactation: Because of the abortifacient property of the Misoprostol component. abdominal pain. a dose of 100 mcg can be used. If this dose cannot be tolerated. Gynecological: Spotting. allergic reactions (including pruritus. Cerebrovascular and cardiovascular disease). Precaution should be taken in conditions where hypertension might precipitate severe complications (e. dyspepsia. Misoprostol should be taken with a meal. hypermenorrhea. cramps. diarrhea and other GI symptoms. and the last dose of the day should be at bedtime. it is contraindicated in women who are pregnant. It is indicated in the treatment of systemic candidiasis. Postpartum Hemorrhage (PPH) treatment: 1000 mcg rectally or. blurred vision. sick sinus syndrome.Product Guide prolonged use hypokalaemia. Mild to moderate hypotension.5 mg twice daily. ventricular extrasystoles. Non cardiovascular QT wave prolonging medicinal products (e. astemizole. cardiogenic shock. sertindole. disopyramide. intravenous erythromycin). Atrial fibrillation. macrolide antibiotics. oral midazolam or triazolam should not be given concurrently with Itraconazole. Dosage & Administration: The usual recommended starting dose of Ivabradine is 5 mg twice daily which may be increased • Cardiovascular QT wave prolonging medicinal products (e. Drug Interaction: QT wave prolonging medicinal products is not recommended. digoxin. unstable angina. headaches. quinidine. Use in Pregnancy and Lactation: Itraconazole is contraindicated in pregnancy. sino-atrial block.g. Contraindication and Precaution: History of hypersensitivity to Ivabradine or any of the excipients. HMG-CoA reductase inhibitors such as simvastatin. phenytoin. Side Effect: Visual symptoms. Moderate hepatic insufficiency. cisapride. I Ivanor TM Active Ingredient: Hydrochloride. Significant interactions also observed during co-administration of rifampin. oedema and hair loss reported. Severe renal insufficiency. acute myocardial infarction. Contraindication and Precaution: Known hypersensitivity. or In combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is > 60 bpm. Usual dose is 1 tablet in the morning and 1 tablet in the evening during meals. depending on therapeutic response. • The concomitant use of cardiovascular and non cardiovascular QT wave prolonging medicinal products with ivabradine should be avoided since QT wave prolongation may be exacerbated . Drug Interaction: The drugs like terfenadine. and calcium channel blockers. Breast feeding while receiving Itraconazole is not recommended.g. 109 after 3-4 weeks of treatment to 7. severe hepatic insufficiency. bepridil. phenobarbital. resting heart rate below 60 bpm before treatment. 1st degree AV block. heart failure. halofantrine. pentamidine. pimozide. and dizziness. sotalol. mefloquine. ibutilide. HIV protease inhibitors). severe hepatic disease. combination with strong cytochrome P450 3A4 inhibitors (such as azole antifungals. ziprasidone. Patients with congenital QT syndrome or treated with QT wave prolonging medicinal products. cisapride. Preparation: 100 mg Capsule. Ivabradine Indication: Symptomatic treatment of chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm. Ivanor is indicated: • • In patients unable to tolerate or with a contra-indication to the use of betablockers. severe hypotension (< 90/50 mmHg). pacemaker dependent. bradycardia. amiodarone). 3rd degree AV block. • as an adjuvant in severe painful . inflammation and swelling. prolonged use may result in overgrowth of nonsusceptible organisms. Indication: Short-term treatment in the following acute conditions: • post-traumatic swelling pain. close cardiac monitoring is needed. ocular discomfort.110 by heart rate reduction. inflammation and • post-operative pain. As with other anti-infectives. infection. If superinfection occurs. Preparation: 0. Therefore. Use in Children: Children and adolescents: Not recommended. primary dysmenorrhoea or adnexitis. Contraindication and Precaution: In patients with a history of hypersensitivity to Moxifloxacin. Indication: Bacterial conjunctivitis. or to any of the components in this medication. Product Guide Moxifloxacin Hydrochloride ophthalmic solution. • non-articular rheumatism. ocular pain. Use in Pregnancy and Lactation: Moxifloxacin Hydrochloride ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Side Effect: Ocular: Conjunctivitis. rash. dry eye. K Preparation: 5 mg & 7. • painful syndromes column. to other quinolones. ocular hyperemia.g. and rhinitis. Iventi® Eye Drops Active Ingredient: Moxifloxacin. ivabradine is contra-indicated during breast-feeding. following dental or orthopaedic surgery. otitis media. keratitis. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.5% Eye Drops. ocular pruritus. e.g. increased cough. Caution should be exercised when Moxifloxacin hydrochloride ophthalmic solution is administered to a nursing mother. If the combination appears necessary. ivabradine is contra-indicated during pregnancy. Use in Pregnancy & Lactation: Fertility: Studies in rats have shown no Effect on fertility in males and females Pregnancy: There are no or limited amount of data from the use of ivabradine in pregnant women. and tearing. gynaecology. decreased visual acuity. Breast-feeding: Animal studies indicate that ivabradine is excreted in milk. of the vertebral • painful and/or inflammatory conditions in • migraine attacks. e. discontinue use and institute alternative therapy. Drug Interaction: Drug-drug interaction studies have not been conducted with Kalinac TM Active Ingredient: Diclofenac Potassium. pharyngitis. Therefore. Dosage and Administration: One drop in the affected eye 3 times a day for 7 days.5 mg Tablet. Non-ocular: fever. subconjunctival hemorrhage. including fungi. indifference or antagonism in vitro against these viruses. preferably before meals. synergistic. or throat. or allergic type reactions after taking aspirin or other NSAIDs. Children: Children over 14 years of age: up to 75mg daily in divided doses. K Kitex TM Active Ingredient: Dexketoprofen Indication: Symptomatic treatment of pain and inflammation of mild or moderate . However. Breast-feeding is contraindicated in patients taking this drug. if serious side-Effects occur. antiviral activity against herpes simplex virus type 1 and 2 in in-vitro replication studies.g. bloody diarrhoea.g. peptic ulcer (with or without bleeding or perforation). Gastrointestinal: Occasional: epigastric pain. Diclofenac Potassium is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery Side Effect: Side-Effects to diclofenac are usually mild and transient. anaphylactic-like reactions to NSAIDs have been reported in such patients. urticaria. The tablets should be swallowed whole with liquid. Dosage & Administration: Adults: Following an initial loading dose of 50mg. rarely fatal.. The maximum daily dose is 150mg. liver enzyme levels should be monitored during treatment. vomiting. MIGRAINE: An initial loading dose of 50mg. itching. Dosage & Administration: 200 mg one tablet once daily. e. 25-50mg is to be taken every eight hours if necessary. Drug Interaction: acyclovir have shown dose-dependent. Preparation: 200 mg Tablet. Diclofenac Potassium should not be given to patients who have experienced asthma. In patients with a previous history of liver disease. diarrhoea. other gastro-intestinal disorders (e. abdominal cramps. Rare: gastro-intestinal bleeding. Severe. an idiosyncratic liver reaction may occur (incidence 1:10. Contraindication & Precaution: Diclofenac Potassium tablets are contraindicated in patients with known hypersensitivity to diclofenac.000). Preparation: 50 mg tablet Ketoral ® Active Ingredient: Ketoconazole.Product Guide inflammatory infections of the ear. otitis. nausea. dyspepsia. diclofenac should be discontinued. Ketoconazole and vidarabine showed interference. Lactation: Diclofenac Potassium should be 111 used with cautions in nursing mothers. Indication: Superficial and deep mycoses. Use in Pregnancy & Lactation: Pregnancy: Use of Diclofenac Potassium should be avoided during the pregnancy. flatulence. anorexia). Use in Pregnancy and Lactation: Ketoconazole is contraindicated in pregnancy. then if necessary a further 25-50mg after 2 hours. nose. pharyngotonsillitis. Side Effect: Nausea. Contraindication & Precaution: Pregnancy and patients with acute liver pathology. skin rash. pentoxifylline. hot flushes. hydantoins. their combination with phenylbutazone. Product Guide K-one® MM Composition: Phytomenadione. Preparation: 25 mg Tablet. VII. fatigue. To ensure a total protection of the newborns. 3 prophylactic doses of Vitamin K should be administered orally following the dosing schedule mentioned above. shivering & general malaise. Children over 1 year of age are could be given 5-10 mg orally. such as musculo-skeletal pain. sulphonamides or salicylates). diarrhea. .g. vomiting. Use in Pregnancy and Lactation: The use of Dexketoprofen tablets during pregnancy or breast-feeding is not recommended. IX and X) of various etiologies. anticoagulant medicines. mifepristone and quinolone antibiotics. in the case of breast-fed children. Dosage & Administration: The dose of Dexketoprofen 25 mg tablets depends on the type. beta-blockers. heartburn are common side Effects. zidovudine. and other forms of hypovitaminosis K (e. with further doses as required. probenecid. • Prevention and treatment of bleeding Dosage and administration: Prophylaxis: Mild Hemorrhage or hemorrhagic tendency: The usual dose for neonates is 2 mg orally at or just after birth. constipation. with no more than 3 tablets daily.1ml) dose IM is recommended in children who are not assured of receiving a second oral dose or. nervousness. cyclosporine or tacrolimus. and after prolonged treatment with antibiotics.5th day and another 2 mg on 28th . including over dosage of courmarin-type anticoagulants. palpitations. dizziness. Then 2 mg on 4th . lithium.sulphonylureas. ACE inhibitors. who are not assured of receiving a third oral dose. • Haemorrhage or risk of haemorrhage as a result of severe hypoprothrombinemia” (i.30th day orally. The recommended dose is generally 1 tablet every 8 hours. menstrual pain and dental pain. Indication: • Prophylaxis and treatment of haemorrhagic disease in the newborn. 1 mg by intravenous injection. Therapy: Initially. based on the clinical picture and coagulation status. in obstructive jaundice as well as liver and intestinal disorders. dry mouth.e. sulphonamide type antibiotics. methotrexate. Uncommon side Effects include sleep disorders. cardiac glycosides. Drug Interaction: Other NSAIDs. Precaution should be exercised during using Dexketoprofen tablets in patients who are allergic to any other NSAIDs. deficiency of clotting factors II. headache. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route. stomach pain. A single 1 mg (0. K Side Effect: Nausea. flatulence. diuretics. due to vitamin K deficiency. vertigo. severity and duration of pain. Contraindication & Precaution: Dexketoprofen tablets are not recommended to use in patients who are allergic to this product or aspirin or other non-steroidal anti-inflammatory medicines.112 intensity. nervousness. impairment of renal function. rash.Product Guide Neonates with special risk factors (Prematurity.depression. nausea. 50 mg up to 3 times daily. headache. Drug Interaction: Anticoagulant or thrombolytic agent. osteoarthritis. visual disturbance. Adverse GI Effects should be considered in patients receiving Ketoprofen. diarrhoea. Side Effect:There are isolated unconfirmed reports on the possible occurrence of anaphylactoid reactions and venous irritation or phlebitis after parenteral use of Phytomenadione injections. Contraindication & Precaution: Ketoprofen is contraindicated in patients with known hypersensitivity to the drug. constipation. obstructive jaundice. signs or symptoms of urinary-tract irritation. Gel : To be applied to the painful area twice daily. Use in Pregnancy and Lactation: It is recommended to avoid medication during pregnancy. Intramuscular and intravenous doses should not exceed 0. flatulence. Elderly : As with other medications it is generally advisable in the elderly to begin ketoprofen therapy at the lower end of the dose range.malaise. . bursitis and tendinitis. dysmenorrhoea or postoperative pain and acute gout or softtissue disorders. SR Capsule : 100-200 mg once daily. maternal use of anticoagulants or anti-epileptics]: 1 mg intramuscularly or intravenously at birth or shortly after birth if the oral route is unsuitable. Paediatric dosage : Not established for intramuscular use. Side Effect: Dyspepsia. taken with food to minimize gastrointestinal disturbance. stomatitis. birth asphyxia (inadequate intake of oxygen by the baby during birth process). 100-200 mg daily in 2-4 divided doses with food. it is not recommended for Phytomenadione to be given to expectant mothers as prophylaxis of hemorrhagic disease in the newborn. Preparation: Phytomenadione 2 mg / 0.5 kg. It is contraindicated in patients with known hypersensitivity to any of its constituents. vomiting. hydrochlorothiazide. tinnitus. The size and frequency of further doses should be based on coagulation status.4 mg/kg in premature infants weighing less than 2. and rheumatoid arthritis. Precaution & Contraindication: Careful monitoring of the coagulation parameters is necessary for patients with severely impaired liver function after administration of Phytomenadione. urticaria. methotrexate. abdominal pain. inability to swallow. Vitamin K1 should be given to pregnant women only if the benefit to the mother outweighs the risk to the fetus. For pain and dysmenorrhoea. Use in Pregnancy & Lactation: Though Vitamin K1 does not readily cross the placental barrier and only a small fraction of administered Vitamin K1 enters into the breast milk. dreams. should not be used during K Kop TM Active Ingredient: Ketoprofen. or other sensitivity reaction is precipitated by aspirins or other NSAIDs. dizziness. For rheumatic disease. IM injection: Adults : 50 to 100 mg every four hours. salicylates. Dosage and Administration: Tablet : 50-100 mg daily. Ketoprofen is contraindicated in patients in whom asthma. repeated up to a maximum of 200 mg in twenty-four hours for up to 3 days. anorexia.2 ml Oral / IM / IV 113 Indication: Ankylosing spondylitis. including ß-blockers. muscle cramps. mood disturbances. polyuria. malaise. L Laxyl ® Active Ingredient: Bromazepam. hepatic impairment. avoid within 1 month of myocardial infarction. withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops. preferably in the morning. Laciten® Active Ingredient: Lacidipine. headache. gastric ulcers. Preparation: 15 mg and 30 mg Capsule. psychosomatic disorders. Dosage & Administration: 30 mg daily. palpitation. aortic stenosis. unstable angina. skin rash etc. Contraindication & Precaution: Contraindication: Hypersensitivity to any ingredient of this product. Indication: Laxyl is indicated for the treatment of anxiety & anxiety related disorders like emotional disturbance. headache. No specific Preparation: 2 mg. 15 mg daily as maintenance dose. The dose may be increased to 4 mg and then. dizziness. Drug Interaction: The plasma concentration of Lacidipine may be increased by simultaneous administration of cimetidine. diuretics. Indication: Duodenal ulcer. edema. pylori eradication. to 6 mg after 3 to 4 weeks. dry or sour mouth or throat. Side Effect: Gastrointestinal disturbances. ACE-inhibitors etc. tolbutamide or warfarin. avoid grape fruit juice. poor cardiac reserves. asthenia. Preparation: 50 mg Tablet. Zollinger-Ellison Syndrome. functional disturbance in the gastrointestinal system. if necessary. Contraindication & Precaution: Known hypersensitivity. rarely gastrointestinal disturbances.114 breast feeding unless unavoidable. cardiogenic shock. 4 mg Tablet Lanso® Active Ingredient: Lansoprazole. dizziness. functional disturbance in the genitourinary system. Use in Pregnancy & Lactation: Should not be used during pregnancy or lactation. H. gum hyperplasia. Product Guide pharmacodynamic interaction problems have been identified in studies with common antihypertensive agents or with digoxin. 100 mg and 200 mg SR Capsule. 25 mg/gm Gel and 100 mg/2 ml IM Injection. Side Effect: Generally well tolerated. . erosive esophagitis. Indication: Hypertension either alone or in combination with other antihypertensive agents. Use in Pregnancy & Lactation: Should be avoided in pregnancy. Precaution: Cardiac conduction abnormalities. Some individuals may experience minor side Effects like flushing. impaired left ventricular function. Dosage & Administration: 2 mg once daily. Lebac TM Indication: Infertility. the drug should be used with caution in nursing mother. phobic or obsessional states. sinusitis. particularly candida.eosinophilia.neutropenia. cellulitis.urticaria. sedation. peritonitis. bacillary dysentery. caution is advised when driving or using machinery. 500 mg and 1 gm IM/IV Injection. Dosage and Administration: 1-2 gm daily in 2 to 4 divided doses. chronic psychosis. diarrhoea and abdominal discomfort. Lerozol ® L Active Ingredient: Letrozole.Superinfection with resistant microorganisms. Nursing Mothers: Caution should be exercised when letrozole is administered to a nursing woman. impetigo. elevation of hepatic enzyme values. . allergic Preparation: 2. vomiting. angioedema and anaphylaxis. lobar and bronchopneumonia.Product Guide Dosage & Administration: 3 mg to 18 mg daily in divided doses. pseudomembranous colitis. Preparation: 250 mg and 500 mg Capsule. 250 mg/5 ml Forte Powder for Suspension. Drug Interaction: Co-administration of letrozole and tamoxifen 20 mg daily results reduction of plasma levels of Letrozole. unsteadiness and ataxia. otitis media.skin rashes. pyelonephritis.25 ml Powder for Paediatric Drops. 125 mg/1. Precaution: Since fatigue and dizziness have been observed with the use of letrozole and somnolence was uncommonly reported. surgical prophylaxis. dosage may need to be reduced. 115 reactions. acute pulmonary insufficiency. Pregnancy : Pregnancy Category D. laryngotracheobronchitis. Contraindication & Precaution: Patients with known hypersensitivity to benzodiazepines. In patients with chronic pulmonary insufficiency. enteritis. Thrombophlebitis. and in patients with chronic renal or hepatic disease. abscess. urethritis. bone and joint infection. Use in Pregnancy and Lactation: Not recommended. Side Effect: Nausea.5 mg Tablet. Pediatric Use: Not recommended Active Ingredient: Cephradine Indication: Pharyngitis. respiratory depression. 125 mg/5 ml Powder for Suspension. acute and chronic bronchitis. cystitis. furunculosis. Contraindication and Precaution: Hypersensitivity to any Cephalosporin antibiotic. Use in Pregnancy and Lactation: The drug should be used during pregnancy only when clearly indicated. tonsilitis. Side Effect: Common adverse Effects include drowsiness. Preparation: 3 mg Tablet. ER positive breast cancer. Infants and children: Between 50 and 100 mg/kg/day in divided doses. The exact dosage will depend on clinical response. Levostar Syrup: Adults: 5-10 ml three times daily. 2 mg Tablet. Children (upto 11 years): 5 ml three times daily. and children 6 years of age and older with reversible obstructive airway disease. Down Syndrome.116 Product Guide above 12 years: 1-2 mg three times daily. 1 mg/5 ml Syrup. burning substernal or epigastric pain. High Cholesterol. muscle cramps. Children (upto 11 years): 1 mg three times daily. Indication: Heart Diseases . fatigue and sleeplessness. they should be used with caution to avoid deleterious cardiovascular Effects. nausea. Male infertility and Hyperthyroidism. Kidney Disease. vomiting. Use in Pregnancy and Lactation: Use of oral Levosalbutamol in pregnant or nursing mothers should be considered only if the expected benefit to the mother is greater than any possible risk to the foetus or the infant. headache. Potentially serious hypokalemia may result from ß2 agonist therapy. Preparation: 1 mg. Drug Interaction: Short-acting sympathomimetic bronchodilators or epinephrine and If additional adrenergic drugs are to be administered by any route. Dosage and Administration: Levostar 1 & 2 mg Tablets: Adults and adolescents . especially coronary insufficiency. Side Effect: Generally well tolerated. cardiac arrhythmias or hypertension. Chronic Fatigue Syndrome. Levostar TM Active Ingredient: Levosalbutamol Indication: Treatment or prevention of bronchospasm in adults.. Dosage should begin at 50 mg/kg/day. steroids and diuretics.fine tremors of the skeletal muscle (particularly the hand). Particular caution is advised in acute severe asthma as this Effect may be potentiated by hypoxia and by concomitant treatment with Xanthine derivatives. Levocar® Active Ingredient: Levocarnitine. nervousness. Oral Levosalbutamol should be used with caution in patients with cardiovascular disorders. Intermittent Claudication. Dementia and memory impairment. Congestive Heart Failure. with a maximum of 3 g/day. Contraindication and Precaution: Hypersensitivity to any of the components of the formulation. dizziness. Preparation: 330 mg Table and 500mg/ 5 ml Solution. L Contraindication & Precaution: No known contraindication. Side Effect:Hypokalaemia. Supplemental Levocarnitine is not advised for nursing mothers. Dosage and Administration: Adults: 1 to 2 gm per day in divided doses. It is not known whether Levocarnitine is excreted in human milk. adolescents. Use in Pregnancy & Lactation: Pregnancy Category B.palpitation. diarrhoea. Inositol. Calcium. angina. 200 puffs. photosensitivity. Contraindication: Hepatic or severe renal dysfunction. Contraindication and Precaution: Hypersensitivity to any of the components of the formulation. peripheral edema. L Livwel ® Active Ingredient: Vitamin A (as Retinol Palmitate and Beta Carotene). Biotin. B1. Hypersensitivity to fenofibrate. Indication: Hyperlipidemias of Type IIa.g. palpitations. Manganese. Dosage and Administration: One 200 mg capsule/ 160 mg Tablet. Preexisting gallbladder disease. cholelithiasis. . Uses in Pregnancy & Lactation: Administration of the drug during pregnancy should be considered only if the expected benefit to the mother is greater than any possible risk to the foetus. hepatomegaly.Children of all ages & infants.Product Guide 117 TM Levostar Inhaler III. C. including primary biliary cirrhosis. Magnesium. IIb. Riboflavin. myalgia.Potassium. B12. cholecystitis.Adults (especially who cannot intake supplements in solid dosage forms e. Cyclosporine.4 teaspoonful daily. Zinc. Indication: Levostar is indicated for the treatment or prevention of bronchospasm in adults. IV and V. Side Effect: Potentially serious hypokalaemia may result from ß2 agonist therapy. tachycardia. Chromium. Lipired TM Active Ingredient: Fenofibrate. myasthenia. Drug Interaction: Oral Anticoagulants. Resins. Folic acid. steroids and diuretics. adolescents and children 4 years of age and older with reversible obstructive airway disease. Dosage & Administration: For adults: 3 . E. . Dosage and Administration: Adults and children above the age of 4 yrs : 1 or 2 puffs as necessary. Particular caution is advised in acute severe asthma as this Effect may be potentiated by hypoxia and by concomitant treatment with Xanthine derivatives. tablet and who suffer gastrointestinal side Effects after taking solid dosage forms).Para-Amino Benzoic Acid. Iodine. rhabdomyolysis. B6. Preparation: 200 mg Capsule & 160 mg Tablet. Preparation: Inhaler : 50 mcg/puff. Active Ingredient: Levosalbutamol. Drug Interactions: Other short-acting sympathomimetic bronchodilators or epinephrine should be used with caution with levosalbutamol. eczema. Selenium. Side Effect: Hepatitis. Serum potassium levels should be monitored in such situations. and migraine. D3. Choline Indication: Livwel Syrup is indicated in multivitamin & multimineral deficiencies in: . and patients with unexplained persistent liver function abnormality. Pantothenic Acid. Niacin. upper respiratory symptoms.2% should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. headache. A decision should be made whether to discontinue nursing or to discontinue the drug. tonsillitis sinusitis. corneal staining/erosion.ocular hyperemia.4 years: 1-2 teaspoonful daily: For infants up to 1 year: 1 teaspoonful daily. conjunctival edema. antihypertensives. asthenia. eyelid erythema. the possibility of an additive or potentiating effect with CNS depressants should be considered. foreign body sensation. tearing.2%. ocular irritation. ocular allergic reactions. Use in Pregnancy & Lactation: The specific information is not available in this respect. urinary tract infections including pyelonephritis and . Tricyclic antidepressants and/or cardiac glycosides are advised. blurring. ocular pruritus.118 For children of 4 . Dosage and Administration: One drop in the affected eye(s) three times daily.3 teaspoonful daily.conjunctival hemorrhage. abnormal vision and muscular pain.ocular dryness. Skin and soft tissue infections. Product Guide Drug Interaction: Although specific drug interaction studies have not been conducted with Brimonidine Tartrate ophthalmic solution 0. For children of 1 . or thostatic hypotension or thromboangiitis obliterans. bronchitis.2% Eye Drops.12 years: 2 . photophobia. fatigue/ drowsiness. in patients with depression. Raynaud’s phenomenon. Side Effect: Oral dryness. pharyngitis. Contraindication & Precaution: Supplement should not be used in over dosage or should not be used long time without the recommendation by a physician. eyelid edema.ocular ache/pain. taking into account the importance of the drug to the mother. TM L Preparation: 100 ml and 200 ml Syrup. blepharitis. Loracef Active Ingredient: Cefaclor. Indication: Pneumonia.lid crusting. gastrointestinal symptoms. Caution should be exercised in treating patients with severe cardiovascular disease. Locular® Eye Drops Active Ingredient: Brimonidine. conjunctival follicles. Contraindication and Precaution: In patients with hypersensitivity to Brimonidine Tartrate and also in patients receiving monoamine oxidase (MAO) inhibitor therapy. otitis media. or as directed by the physician. cerebral or coronary insufficiency. Side-Effect: Generally the product is well tolerated. Indication: For lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension. burning and stinging. conjunctival blanching. approximately 8 hours apart. Preparation: 0. Caution in using concomitant drugs such as systemic beta-blockers. dizziness. Use in Pregnancy and Lactation: Brimonidine Tartrate ophthalmic solution 0. 125 mg/5 ml Suspension. Children : 20 mg/kg/day in divided doses every 8 hours. Dosage and Administration: Adult and children over 6 years: One tablet daily. Transient hepatitis and cholestatic jaundice. Side Effect: Diarrhoea. transient lymphocytosis and leucopenia. thrombocytopenia. nausea. Use in Pregnancy and Lactation: Caution is recommended in the use of the drug in early pregnancy. . Contraindication & Precaution: Hypersensitivity. Perennial allergic rhinitis. caution in the presence of markedly impaired renal function. Loratin® Active Ingredient: Loratadine. pruritis and urticaria. Children aged 2-5 years : 1/2 tablet daily. 119 Dosage and Administration: Adult and child over 6 years: One Loratin 10 mg tablet or two teaspoonful (10 ml) Loratin suspension once daily. Children aged 2-5 years: 5 ml or 1 teaspoonful (5 mg) suspension once daily. Contraindication: Loratadine is contraindicated in patients who have shown hypersensitivity to its ingredients or idiosyncrasy. Preparation: 10 mg Tablet and 5 mg/5 ml Suspension. Not recommended for children under 2 years of age. Indication: Allergic rhinitis. slight elevation in AST. ALT or alkaline phosphate. Eosinophilia. Use in Pregnancy and Lactation: Loratadine should be used during pregnancy only if clearly needed. Loratadine should not be administered to lactating mother. hypertonia. nervousness. Preparation: 500 mg Capsule. Skin allergies including Chronic Idiopathic Urticaria (CIU). Reversible interstitial nephritis. Contraindication: Hypersensitivity to its ingredients or idiosyncrasy. eruptions. nausea and vomiting. fatigue. L Loratin® Fast Active Ingredient: Loratadine. dizziness. Dosage & Administration: 250 mg every eight hours. Reversible hyperactivity.Product Guide cystitis. Serum sickness. hallucinations and somnolence have been reported rarely. Skin allergies including Chronic Idiopathic Urticaria (CIU). confusion. Loratadine is not recommended for children under 2 years of age. Drug Interaction: The nephrotoxicity of aminoglycoside antibiotics such as gentamicin and tobramycin may enhanced by any Cephalosporin. overgrowth of non-susceptible organisms. Caution should be exercised when Cefaclor is administered to a nursing women.25 ml Paediatric Drops. tachycardia and syncope. headache. 125 mg/1. Side Effect: Anticholinergic Effects. Indication: Seasonal allergic rhinitis. or to other drugs of similar chemical structures. is contraindicated in patients with narrow angle glaucoma or urinary retention. Contraindication & Precaution: Loratadine/Pseudoephedrine Sulfate combination is contraindicated in patients Lubtear® Eye Drops Active Ingredient: Dextran 70 and Hypromellose. Use in Pregnancy and Lactation: Loratadine should be used during pregnancy only if clearly needed. Product Guide who are hypersensitive to this medication or to any of its ingredients. Loratadine should not be administered to lactating mother. and nasal congestion & sinus pressure associated with sinusitis. Loratin Plus tablet should be administered when both the antihistaminic properties of Loratadine and the nasal decongestant activity of Pseudoephedrine Sulfate are desired in patients 12 years of age and older. increased intraocular pressure. Loratadine/Pseudoephedrine Sulfate combination tablets should be used with caution in patients with hypertension. nausea. the recommended dose of Loratin Plus tablet is once daily. It is also contraindication in patients with severe hypertension. headache. ischemic heart disease. itching. tachycardia and syncope. However. Dosage & Administration: In adults and children 12 years of age and over. itching of the nose or throat due to allergic rhinitis or other upper respiratory allergies. Preparation: 10 mg Orally Dispersible Tablet. diabetes mellitus. severe coronary artery disease and in those who have shown hypersensitivity or idiosyncrasy to its components to adrenergic agents. hyperthyroidism. Side Effect: Generally well tolerated. Use in Pregnancy & Lactation: It is not known if this combination product is excreted in human milk.This product. therefore a decision should be made whether to discontinue nursing or to discontinue Loratin Plus®. .due to its Pseudoephedrine Sulfate component. both Loratadine and Pseudoephedrine when administered alone passes into breast milk. symptoms of common cold. it is best recommended that Pseudoephedrine Sulfate should be administered in once daily formulation and be taken in the morning instead of night.120 Side Effect: Fatigue. watery eyes. and in patients receiving monoamine oxidase (MAO) inhibitor therapy or within fourteen days of stopping such treatment. sneezing. Preparation: Loratadine 10 mg and Pseudoephedrine Sulfate 240 mg Tablet. Central nervous system stimulation with convulsions or cardiovascular collapse with accompanying hypotension may be produced by sympathomimetic amines. renal impairment or prostatic hypertrophy. taking into account the importance of the drug to the mother. Loratin Plus tablet also temporarily relieves runny nose. nasal congestion. Loratin Plus TM Active Ingredient: Loratadine Pseudoephedrine Sulfate and L Indication: Loratin Plus is indicated for the relief of symptoms of seasonal and perennial allergic rhinitis. As Loratin Plus contains Pseudoephedrine Sulfate which may cause agitation and insomnia as side Effects. Dosage & Administration: Body Weigh 5-15 kg 15-25 kg 20-35 kg Day 1 0 hour 1 Tablet 2 Tablet 3 Tablet 8 hours later 1 Tablet 2 Tablet 3 Tablet 4 Tablet Day 2 Morning 1 Tablet 2 Tablet 3 Tablet 4 Tablet Day 2 Evening Morning 1 Tablet 1 Tablet 2 Tablet 2 Tablet 3 Tablet 3 Tablet 4 Tablet 4 Tablet Evening 1 Tablet 2 Tablet 3 Tablet 4 Tablet L 35kg & 4 Tablet above Contraindication & Precaution: Hypersensitivity to any of the ingredients. It is not evaluated for prophylaxis of malaria. It is also used for the temporary relief of burning and irritation due to dryness of the eye and for use as the protectant against further irritation. patients with family history of bradycardia or severe cardiac disease & patients with known electrolyte imbalance. this product should only be used in pregnancy and lactation if it is considered essential by the physician.Product Guide 121 Indication: As a lubricant and artificial tear in dry eye and other ocular irritation syndromes associated with deficient tear or mucous secretion. if the patient experiences any reaction in eye or other part of the body after using this medication then consult with doctor. falciparum infection of adults.cerebral malaria or other severe manifestation of severe malaria including pulmonary oedema or renal failure. Therefore. Preparation: 10 ml sterile solution. Dosage & Administration: Adults and children: One or two drops three times daily or as directed by the physician. Side Effect: There are no known side Effects with the use of it. Hence. Use in Pregnancy & Lactation: There is insufficient evidence as to the safety in pregnancy and lactation. should not be . Lumertam® Active Ingredient: Artemether and Lumefantrine. Contraindication & Precaution: This product contains Benzalkonium Chloride BP and should not be used when soft contact lenses are being worn. however. This combination also prevents cornea to damage in patients with keratoconjunctivitis and for ocular lubrication. Indication: Lumertam is indicated in the treatment and standby emergency treatment of acute uncomplicated Plasmodium falciparum malaria including mixed P. children and infants weighing from 5 kg and above. antacids and laxative). diarrhea. appendicitis. It is also indicated for the relief of flatulence. or as directed by the physician.122 used in those conditions. Chronic high dose should be avoided. Do not take with tetracycline antibiotics. sensitivity to aluminium. with a history of kidney problems or taking citrate salts (found in some calcium supplements. dyspepsia. Product Guide Side Effect: Generally well tolerated and most side Effects are of mild to moderate in severity and duration. heartburn. Side Effect: Constipation. Use in Pregnancy & Lactation: Not recommended. 20 to 60 minutes after meals and at bedtime. or as directed by the physician. Indication: Hyperacidity. M Dosage & Administration: Maganta Plus tablet: 1-4 chewable tablets. gastroesophageal reflux. abdominal distention and windy colic. Use in Pregnancy & Lactation: Pregnancy category C. Contraindication & Precaution: intestinal obstruction. chronic diarrhea. Maganta Plus TM Active Ingredient: Magaldrate and Simethicone. 20 to 60 minutes after meals and at bedtime. Antacids can interfere with the absorption of iron preparation. Preparation: (Artemether 20 mg + Lumefantrine 120 mg)/Tablet. . gastric and duodenal ulcer. gastritis. renal function impairment. magnesium and simethicone. intestinal pain. Malacide® Active Ingredient: Sulphadoxine + Pyrimethamine. Should be cautious. so should be used in pregnancy only when necessary. Maganta Plus Suspension: 2-4 teaspoonfuls (10-20 ml) of suspension. if allergic to any ingredient to Magaldrate and Simethicone. Preparation: Maganta Plus tablet: Each chewable tablet contains Magaldrate USP 480 mg and Simethicone USP 20 mg. Maganta Plus Suspension: Each 5 ml contains Magaldrate USP 480 mg and Simethicone USP 20 mg. cellulitis. Neonates : 50 mg/kg/day in 2-4 divided doses. cystitis and asymptomatic bacteriuria. In rare cases. 123 Dosage and Administration: Curative : Adults : 2-3 tablets. Dosage and Administration: 1gm every 12 hourly. lung abscess and post-operative chest infections. dose should be continued during stay and for 4-6 weeks after return. Once weekly Once every 2 weeks 2 tablets Adults Paediatric patient Weight (kg) Once weekly <45 11/2 1 tablets 31-45 1 21-30 3/4 11-20 1/2 5-10 1/4 Side Effect: Drug rash. In severe infections 150-200 mg/kg/day in divided doses. folate antagonists (e. methotrexate. headache. septic arthritis. Preparation: (Sulfadoxine 500 mg + Pyrimethamine 25 mg)/Tablet. Drug Interaction: anticonvulsants). megaloblastic anemia Fatigue. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. Children : 100-150 mg/kg/ day in 2 to 4 divided doses. Maxcef TM Active Ingredient: Cefotaxime. infected bronchiectasis. 9-14 years : 2 tablets. leukopenia. osteomyelitis. cotrimoxazole. Prophylactic : First dose 1 or 2 days befroe arrival in an endemic area. stomatitis. premature and newborn infants. Feeling of fullness. In very severe infections doses up to 200 mg/kg/day may be required. nausea. peritonitis and wound infections. rarely vomiting. fever. suppressive or prophylactic management.g. M Use in Pregnancy and Lactation: Malacide is contraindicated during pregnancy. acute and chronic pyelonephritis. . Prophylaxis:The administration of Cefotaxime prophylactically may reduce the incidence of certain post operative infections in patients undergoing surgical procedures. meningitis and other sensitive infections suitable for parenteral antibiotic therapy. bacterial pneumonia. Indication: Acute or chronic bronchitis. polyneuritis may occasionally occur. thrombocytopenia.Product Guide Indication: Malaria. gonorrhoea. Children under 4 years : 1/2 tablet. pelvic inflammatory disease. pruritus and slight hair loss have been observed. 4-8 years: 1 tablet. 124 Product Guide Contraindication and Precaution: Hypersensitivity, in renal insufficiency. Side Effect: Mild and transient candidiasis, rashes, fever, transient rises in liver transaminase and/or alkaline phosphatase and diarrhoea. pseudomembranous colitis, changes in renal function,skin rashes,drug fever and very rarely anaphylaxis.Administration of high doses of cephalosporins particularly in patients with renal insufficiency may result in encephalopathy. Drug Interaction: Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics. Pregnancy and lactation: Cefotaxime should not be administered during pregnancy especially during first trimester, without carefully weighing the expected benefit against possible risks. Cefotaxime is excreted in the breast milk. Preparation: 250 mg, 500 mg and 1gm IM/IV Injection. Maxpime TM M Active Ingredient: Cefepime. Indication & Dosage & administration: The recommended adult and pediatric dosages and routes of administration are outlined in the following table. MaxpimeTM (Cefepime) should be administered intravenously over approximately 30 minutes. Before administration ensure that the powder has been fully dissolved in the solution. Site and Type of Infection Dose Frequency gm Every 12 hours Duration (Days) 10 Moderate to severe Pneumonia due 1-2 to S. pneumoniae*, P. aeruginosa, IV K. pneumoniae, or Enterobacter species Mild to moderate Uncomplicated or 0.5-1 gm Every 12 Complicated Urinary Tract Infections, IV/IM hours including pyelonephritis, due to E. coli, K. pneumoniae, or P. mirabilis* 7-10 Product Guide Severe Uncomplicated or Complicated 2 gm IV Urinary Tract infections, including pyelonephritis, due to E- coli or K. pneumoniae* Moderate to Severe Uncomplicated 2 gm IV Skin and skin structure infections due to S. aureus or S. pyogenes Complicated intra-abdominal 2 gm IV infections (used in combination with metronidazole) caused by E.coli, viridans group streptococci, P. aeruginosa, K. pneumoniae, Enterobacter species, or B.fragilis Every 12 hours 10 Every 12 hours 10 125 Every 12 hours 7-10 Pediatric patients (2 months up to 16 years) The maximum dose for pediatric patients should not exceed the recommended adult dose. The usual recommended dosage in pediatric patients up to 40 kg in weight for uncomplicated and complicated urinary tract infections (including pyelonephritis), uncomplicated skin and skin structure infections, and pneumonia is 50 mg/kg/dose, administered every 12 hours (50 mg/kg/dose, every 8 hours for febrile neutropenic patients), for durations as given above. Contraindication & Precaution: Cefepime is contraindicated in patients who have shown immediate hypersensitivity reactions to Cefepime or the cephalosporin class of antibiotics, penicillins or other beta-lactam antibiotics. Side Effect: As with some other drugs in this class, encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor and coma), myoclonus and seizures have been reported. Drug Interaction: Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with Cefepime because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics. Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide. Use inPregnancy & Lactation: Pregnancy (Category B). Nursing Mothers Cefepime is excreted in human breast milk in very low concentrations (0.5 ug/mL). Caution should be exercised when Cefepime is administered to a nursing woman. M 126 Preparation: Maxpime 500 mg IM/IV injection: Pack of 1 vial contains 500 mg Cefepime as Cefepime hydrochloride USP accompanied by a solvent ampoule (contains 5 ml water for injection BP). Maxpime 1 gm IM/IV injection: Pack of 1 vial contains 1 gm Cefepime as Cefepime hydrochloride USP accompanied by a solvent ampoule (contains 10 ml water for injection BP). Maxpime 2 gm IV injection: Pack of 1 vial contains 2 gm Cefepime as Cefepime hydrochloride USP accompanied by a solvent ampoule (contains 10 ml water for injection BP). Product Guide Drug Interaction: Atenolol, enalapril, nifedipine or theophylline, cimetidine, frusemide. Use in Pregnancy & Children: Tamsulosin Hydrochloride capsules are not indicated for use in women and children. Preparation: 0.4 mg Capsule. Melcam® Active Ingredient: Meloxicam. Indication: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis. Dosage and Administration: 7.5-15 mg/ day. Contraindication & Precaution: Hypersensitivity, asthma, nasal polyps, angioneurotic oedema or urticaria, active peptic ulcer, severe hepatic failure, non-dialysed severe renal failure, gastrointestinal bleeding, cerebrovascular bleeding or other bleeding disorders. Side Effect: Nausea, vomiting, abdominal pain, dyspepsia, constipation or diarrhoea, ulcers or gastrointestinal bleeding, skin rash, urticaria, oedema of the lower limbs, asthma, headache, vertigo or drowsiness may occur. Drug Interaction: Other NSAIDs, including high doses of salicylates, Oral anticoagulants, heparin and ticlopidine, Lithium, Methotrexate, Intrauterine contraceptive devices. Use in Pregnancy and Lactation: It is advisable to avoid the administration of Meloxicam during pregnancy. Meloxicam should not be given to nursing mothers. Maxrin TM M Active Ingredient: Hydrochloride. Tamsulosin Indication: Treatment of the signs and symptoms of Benign Prostatic Hyperplasia (BPH). Dosage & Administration: 1(one) capsule once daily. Contraindication & Precaution: Hypersensitivity, orthostatic hypotension; severe hepatic insufficiency, syncope, dizziness, weakness. The treatment of severely renal impaired patients should be approached with caution. Side Effect: Dizziness, abnormal ejaculation, less frequently headache, asthenia, postural hypotension, palpitations, rhinitis, nausea, vomiting, diarrhoea, constipation, Hypersensitivity reactions such as rash, pruritus, urticaria, drowsiness, blurred vision, dry mouth, edema, syncope, angioedema and priapism. Product Guide Preparation: 7.5 mg and 15 mg Tablet. 127 Menoral TM Melixol TM Active Ingredient: Norethisterone. Indication: • Dysfunctional uterine bleeding • Relief of primary and secondary amenorrhea • Timing of menstruation • Endometriosis Dosage & Administration: DUB: 1 tablet 3 times daily PMS: One tablet 1-3 times daily during the luteal phase of the cycle Timing of menstruation: One tablet 2-3 times daily for no longer than 10-14 days Endometriosis: 1 tablet twice daily, should be started between 1-5th day of the cycle Menorrhagia: 1 tablet 3 times daily from day 5-25 of the cycle Contraindication & Precaution: • Known or suspected pregnancy • Lactation • Active thromboembolic processes or a history thereof • Diabetes mellitus with vascular involvement • Presence or history of severe hepatic disease, as long as liver function values have not returned to normal • Presence or history of liver tumors (benign or malignant) • Known or suspected sex hormonedependent malignancies • Hypersensitivity to the active substance or to any of the excipients Side Effect: Visual disturbance, nausea, headache, migraine, edema, dyspnea, hypersensitivity reactions (urticaria, rash). Drug Interaction: Phenytoin, barbiturates, primidone, carbamazepine, rifampicin may decrease therapeutic efficacy. The requirement of Oral anti-diabetics or Active Ingredient: Flupenthixol and Melitracen. Indication: Anxiety along with depression and apathy. Dosage and Administration: 2 tablets per day, morning and at mid day. Contraindication: Hypersensitivity to Melitracen & Flupenthixol,depression of the CNS (e.g. at the time of acute intoxications to alcohol, barbiturates or opiates), state of coma, pheochromocytoma, blood dyscrasy, immediately consecutive recovery to a myocardial infarction, at the time of a cardiac block of any rank, disorders of cardiac conduction as well as coronary insufficiency. The concomitant administration of inhibitors of the MAO is contra-indicated. Precaution and Warning: The administration of this requires prudence among patients presenting an organic cerebral lesion, convulsions, urinary retention, hyperthyroid, parkinson’s syndrome, serious myasthenia, advanced hepatic affection as well as cardiovascular disorders. Among depressive patients, the risk of suicide remains during the treatment. As for all nerve sedatives, a syndrome nerve sedative (potentially fatal) can seldom occur. Extrapyramidal disorders can occur in very rare cases. Side Effect: Side Effects are rare. These could be transient restlessness and insomnia. Preparation: (0.5 mg + 10 mg)/Tablet. M 128 Insulin may be changed. Use in Pregnancy & Lactation: The use of Menoral during pregnancy is contraindicated. Menoral should not be used during lactation. Use in Children: The safety and Effectiveness of bromocriptine for the treatment of prolactin-secreting pituitary adenomas have been established in patients age 16 to adult. No data are available for bromocriptine use in pediatric patients under the age of 8 years. Preparation: Norethisterone 5 mg. Product Guide Preparation: 6 mg Tablet. Metaspray®Nasal Spray Active Ingredient: Mometasone Furoate. Indication: Metaspray Nasal Spray is indicated for the treatment of the nasal symptoms of seasonal and perennial allergic rhinitis, in adults and pediatric patients 2 years of age and older. It is indicated for the prophylaxis of the nasal symptoms of seasonal allergic rhinitis in adult and adolescent patients 12 years and older. It is also indicated for the treatment of nasal polyps in patients 18 years and older. Dosage & Administration: Adults and Children 12 Years of Age and Older: The recommended dose for prophylaxis and treatment of the nasal symptoms of seasonal allergic rhinitis and treatment of the nasal symptoms of perennial allergic rhinitis is two sprays (50 mcg of Mometasone Furoate in each spray) in each nostril once daily (total daily dose of 100 mcg). In patients with a known seasonal allergen that precipitates nasal symptoms of seasonal allergic rhinitis, prophylaxis with Metaspray ® Nasal Spray, 50 mcg (200 mcg/day) is recommended 2 to 4 weeks prior to the anticipated start of the pollen season. Children 2 to 11 Years of Age: The recommended dose for treatment of the nasal symptoms of seasonal and perennial allergic rhinitis is one spray (50 mcg of Mometasone Furoate in each spray) in each nostril once daily (total daily dose of 100 mcg). Nasal Polyps: Adults 18 years of Age and Older: The recommended dose for nasal polyps is two sprays (50 mcg of M Merison TM Active Ingredient: Betahistine. Indication: Vertigo and dizziness associated with the following diseases: Meniere’s disease, Meniere’s syndrome, Peripheral vertigo. Dosage and Administration: Adults : 1 to 2 tablets three times per day after meals. Precaution: Careful Administration: History of digestive ulcer or an active digestive ulcer, bronchial asthma, pheochromocytoma. Adverse Reactions: Nausea or vomiting, Hypersensitivity reactions, such as skin rash. Use during Pregnancy: This drug should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk. viral infection. dosage should be changed to 1 ampoule in every one to three months as maintenance therapy. Drug Interaction: No significant drug interaction reported. bacterial. like other corticosteroids. Indication: For both tablet & injection: Peripheral neuropathies observed in Diabetic neuropathy. Mometasone Furoate. While using nasal corticosteroids. After two months of administration. administered intramuscularly or intravenously 3 times a week. Pregnancy & Lactation: There are no adequate and well-controlled studies in pregnant women. Because other corticosteroids are excreted in human milk. sore throat. anorexia. Lumbago. Vertebral syndrome. Preparation: 500 mcg Tablet. and coughing. Contraindication & Precaution: Hypersensitivity to any of the ingredients of this preparation contraindicates its use. Contraindication & Precaution: Hypersensitivity to Mecobalamin or to any of the excipients used in the preparations. Side-Effect: Side Effects are generally mild and included headache. . caution is required in patients with active or dormant tuberculous infection.Product Guide Mometasone Furoate in each spray) in each nostril twice daily (total daily dose of 400 mcg). Diabetic retinopathy. equivalent to a total of 1500 mcg of Mecobalamin. Nerve Compression Syndrome. Parkinson’s disease. Drug induced neuropathy. 500 mcg/1 ml Ampoule Injection. Amyotrophic lateral sclerosis. Intercostal neuralgia. Preparation: 120 Nasal Sprays (50 mcg in each spray) 129 Alzheimer’s disease. Side Effect: Gastrointestinal symptoms (e. should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. A dose of two sprays (50 mcg of mometasone furoate in each spray) in each nostril once daily (total daily dose of 200 mcg) is also Effective in some patients. caution should be used when Mometasone is administered to nursing women. Methicol Injection: Peripheral neuropathy: Adults 1 ampoule. or in untreated fungal. or ocular herpes simplex. Prolonged use of larger doses of Mecobalamin is not recommended for patients whose occupation requires handling mercury or its compounds. nausea or diarrhea) & skin rash may occur. Entrapment neuropathy. Multiple sclerosis. Use in Pregnancy and Lactation: Not recommended during pregnancy & lactation.g. M Methicol ® Active Ingredient: Mecobalamin. systemic viral infections. Mecobalamin should not be administered for extensive period (months) to patients who do not show clinical response. administered orally in 3 divided doses. Dosage & Administration: Methicol Tablet: Adults 3 tablets. It is not known if Mometasone Furoate is excreted in human milk. Megaloblastic anemia: Adults 1 ampoule administered intramuscularly or intravenously 3 times a week. For injection only: Megaloblastic anemia due to Vitamin B12 deficiency. nosebleeds. Contraindication & Precaution: Hypersensitivity. However. Preparation: 400 mg Tablet. Side Effect: Nausea. few side-effects like skin rash. Indication: Infections of lower respiratory tract.130 Product Guide TM Mevin Indication: Mexlo® 400 Active Ingredient: Lomefloxacin. urticaria and angioedema may appear. Use in Pregnancy & Lactation: No teratogenicity has been shown in animal experiments. Use in Pregnancy and Lactation: Pregnancy is a relative contraindication for lomefloxacin. There after. Mevin is most effective when taken 20 minutes before meals. photosensitivity. Preparation:135 mg tablet. Patient should be advised to avoid sunlight or discontinue therapy if any sign of skin burning. the usual precautions concerning the administration of any drug during pregnancy should be exercised. headache. . Dosage and administration: At the beginning of therapy on Day 1 instill 5 drops into the conjunctival sac within 20 minutes. Side Effect: Generally Mebeverine is well tolerated. rash. the dosage may be gradually reduced. M Mexlo® Eye Drops Active Ingredient: Lomefloxacin. blepharitis. Indication: Conjunctivitis. dizziness and diarrhoea. Drug Interaction: No clinically significant hazardous interactions have been reported. Use in Children: Mebeverine is not recommended in children under 10 years. itching or dermatitis appears.induced corneal ulcers. elderly and children over 10 years: 1 tablet three times daily. Staphylococcus aureus . blepharo-conjunctivitis. Mebeverine does not excrete in the breast milk after administering the therapeutic dose. redness. Precaution: Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group. until Day 7-9 instill 1 drop 2 times daily into the conjunctival sac. Dosage & Administration: 400 mg once daily for 10-14 days. However. After several weeks when the desired effect has been obtained. urinary tract. Active ingradient: Mebeverine Hydrochloride • Symptomatic treatment of IBS • Chronic irritable colon • Spastic constipation • Mucous colitis • Colicky abdominal pain • Persistent non-specific diarrhoea Dosage & Administration: Adults. blisters. swelling. For patients who experience intolerance. Preparation: (Diclofenac Sodium 50 mg and Misoprostol 200 mcg)/Tablet. Long term treatment may enhance development of secondary fungal infections. Antihypertensive agents. dyspnoea. exposure to sunlight or UV-radiation should be avoided. urticaria. Miclofenac 50 BID or Miclofenac 75 BID can be used. diarrhea and other GI symptoms. Drug interactions: Aspirin. Rheumatoid Arthritis: Miclofenac 50 TID or QID. Digoxin. urticaria.Product Guide Contraindication and Precaution: Hypersensitivity to lomefloxacin.5 mg daily at bed time as a single dose or in three divided doses. Antacids. Side Effect: Abdominal pain. asthma. Diuretics. such as Zinc. cyclosporine. The incidence of diarrhea can be minimized by administering this preparation with food and by avoiding coadministration with magnesium-containing antacids. and hypersensitization. allergic reactions. Use in Pregnancy and Lactation: Misoprostol component is contraindicated in women who are pregnant. For patients who experience intolerance. should not be used during 15 minutes preceding and following application of Lomefloxacin. Side Effect: Slight and transient burning. Because of the potential for serious adverse reactions in nursing infants. Dosage and administration: 1. Diclofenac and Indication: Osteoarthritis or rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications. or other allergic-type reactions after taking aspirin or other NSAIDs. Preparation: 0. Use in Pregnancy and Lactation: The drug should only be used when the benefit outweighs the potential risk for the foetus or the infant. phototoxicity. it is not recommended for use by nursing mothers. oral hypoglycemic agents. Migranil ® Active Ingredient: Pizotifen. narrow-angle glaucoma or prostate hypertrophy. Drug Interaction: Preparations containing heavy metals. Lithium. erythema. Contraindication and Precaution: Hypersensitivity.3% Eye Drops. Warfarin. pruritus. Methotrexate. Indication: Migraine. Dosage and Administration: Osteoarthritis: Miclofenac 50 TID. 131 Contraindication and Precaution: In patients with hypersensitivity to Diclofenac or to Misoprostol or other prostaglandins. Dosage . M Miclofenac® Active Ingredient: Misoprostol. It should not be given to patients who have experienced asthma. Miclofenac 50 BID or Miclofenac 75 BID can be used. (Diclofenac Sodium 75 mg and Misoprostol 200 mcg)/Tablet. Contraindication and Precaution: Hypersensitivity to the active ingradient. it can be used if indicated by a physician but with caution. Indication: For the prophylaxis and chronic treatment of asthma in adults and pediatric patients 2 years of age and older. and otitis media during montelukast clinical trials. Preparation: 0. Patients 6-14 years of age: 5 mg daily to be taken in the evening. During the remainder of pregnancy. dyspepsia. Dosage & Administration: Adolescents over 12 years old : 1-2 tablets daily Adults : 2-3 tablets daily at 8 to 12 hours intervals. hypnotics. tranquilizers. sinusitis. Patients 2-5 years of age: 4 mg daily to be taken in the evening. Mirakof ® Active Ingredient: Butamirate Citrate. resolving after dose reduction or treatment withdrawal. M . dizziness and abdominal pain. Side Effect: The common adverse Effect are headache. Drug Interaction: Patients with known aspirin sensitivity should continue avoidance of aspirin or nonsteroidal anti-inflammatory agents while taking montelukast. Indication: Dry (non-productive) cough and also used in pre. Preparation: 10 mg Tablet. Side Effect: Drowsiness. Montene TM Active Ingredient: Montelukast. nausea and constipation Drug Interaction: Alcohol . rash. dizziness. antidepressants & MAO inhibitors. Caution should be used prior to initiating montelukast therapy in nursing mothers. Pediatric patients have experienced diarrhea. The benefits of Butamirate Citrate administration during breast feeding should be carefully weighed against the risks. Use in Pregnancy: There have been no reports of its use in pregnant women. diarrhoea and vertigo have been observed in a few rare cases. Product Guide Preparation: 50 mg Sustained Release Tablet. 5 mg Chewable Tablet & 4 mg Chewable Tablet.5 mg and 1. nausea. Use in children: Not recommended below 12 years of age.132 adjustment may be necessary in patients with kidney insufficiency.5 mg Tablet. dry mouth.& post-operative cough sedation. Side-Effect: Rash. Dosage and Administration: Adolescents and adults 15 years of age and older: One 10 mg tablet daily to be taken in the evening. Contraindication & Precaution: Hypersensitivity to the active ingredient. Use in Pregnancy & Lactation: Butamirate Citrate should not be used during the first trimester of pregnancy. Domperidone should be used with absolute caution in case of children because there may be increased risk of extra-pyramidal reactions. prolactinoma. Dosage and Administration: 1-2 tablet every 6-8 hours daily 15-30 minutes before meals. Use in Pregnancy and Lactation: Not recommended during pregnancy. breast enlargement. infectious. Dry mouth. Dosage and Administration: 1-2 tablet or 10-20 ml suspension every 6-8 hours daily before meals. Drug Interaction: Bromocriptine. galactorrhea. skin rash and itching. increased risk of extrapyramidal reactions. Contraindication and Precaution: Known hypersensitivity to this drug.Product Guide 133 in very small quantities insufficient to be considered harmful. drowsiness. It is secreted in breast milk but in very small quantities insufficient to be considered harmful. Indication: Nausea and vomiting: Acute nausea and vomiting of functional. prolactinoma. breast enlargement. infectious. dietetic origin or induced by radiotherapy or drug therapy or induced in migraine. M . MAO (monoamine oxidase) inhibitors. Radiological studies: Speeding barium transit in followthrough radiological studies. gastro-intestinal stimulation. skin rash. nervousness. soreness. mechanical obstruction or perforation. antimuscarinics and opioid analgesics.4 ml-0. Motifast TM Active Ingredient: Domperidone. acute nausea and vomiting of functional. Children: 2 ml-4 ml suspension/10 kg or 0. organic. It is secreted in breast milk but Motigut TM Active Ingredient: Domperidone. diarrhea. itching and extrapyramidal reactions. dietetic origin or induced by radiotherapy or drug therapy or induced in migraine. Preparation: 10 mg Tablet. drowsiness. should be used with caution in patient with hepatic impairment. Drug interactions: Bromocriptine. galactorrhea.8 ml Paed. Parkinson’s disease: In dopamine-agonist induced nausea and vomiting. in case of neonates. nervousness. Indication: Dyspeptic symptom complex. gastro-intestinal hemorrhage. and soreness and reduced libido. Lactating mother: Domperidone may precipitate galactorrhea and improve post-natal lactation. dry mouth. diarrhea. MAO (monoamine oxidase) inhibitors . antimuscarinics and opioid analgesics Use in Pregnancy and Lactation: Pregnant women: Not recommended during pregnancy. mechanical obstruction or perforation. Side Effect: Hyperprolactinemia. organic. Contraindication and Precaution: Known hypersensitivity. reduced libido. It should be used with caution in patient with hepatic impairment. thirst. headache. Side Effect: Hyperprolactinemia. thirst. headache. drops/ 10 kg 6-8 hours daily. gastro-intestinal hemorrhage. In severe infection one Moxaclav 625mg tablet three times a day or one Moxaclav 1gm tablet two times a day. lower respiratory tract. nose. Acute. rare and infrequent. Preparation: 250 mg. Severe-875 mg every 12 hours or 500 mg every 8 hours. 5 mg/5 ml Suspension. Moxaclav Forte Powder for Suspension: Children of 2-12 years: ½ to 2 teaspoonful b. history of allergy etc. 500 mg Injection. Use in Pregnancy and Lactation: Can be used safely throughout pregnancy at the normal adult dose. and throat. Children of 1-6 years: 1 teaspoonful of Moxaclav Powder for Suspension every 8 hours. Lower respiratory tract infections. H. Dosage and Administration: Adult : Mild/ Moderate-500 mg every 12 hours or 250 mg every 8 hours. Bone and joint infections e. acute uncomplicated (anogenital and urethral infections). skin and skin structure. Diarrhoea. and urethral infections in males and females 3 g as single oral dose. Other infections e. etc. Prepubertal children 50 mg/Kg Amoxicillin.g. Drug Interaction: Concurrent administration of probenecid delays the excretion of Amoxicillin. Prophylactic cover for patients at risk of developing endocarditis when undergoing dental surgery. osteomyelitis. Product Guide Adverse Effect: Mild. 5 mg/ml Paediatric Drops. glandular fever. Gonorrhea. Children of 6-12 years: 2 teaspoonful of Moxaclav Powder for Suspension every 8 hours. M Moxaclav TM Active Ingredient: Co-Amoxiclav (Amoxicillin + Clavulanic Acid) Indication: Upper respiratory tract infections. genitourinary tract. puerperal sepsis. Dosage & Administration: Adults and children over 12 years: One Moxaclav 375 mg tablet three times a day.g. In renal impairment the excretion of antibiotic will be delayed and depending on the degree of impairment it may be necessary to reduce the total daily dose.Children . Skin and soft tissue infections.25 ml Paediatric Drops. Caution should also be exercised in case of erythematous rashes.134 Preparation:10 mg Tablet. Indication: Infections of the ear. intra-abdominal sepsis. 875 mg Tablet. 250 mg/5 ml Forte Suspension. Genito-urinary tract infections. uncomplicated ano-genital. indigestion or skin rashes. 125 mg/5 ml Suspension. combined with 25 mg/kg Probenecid as a single dose Contraindication & Precaution: It is contraindicated for patients hypersensitive to penicillin. Moxacil ® Active Ingredient: Amoxicillin. Can be used safely during lactation in most instances. Severe-45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours. 250 mg DT (Dispersible Tablet). septic abortion.i.d. Children: Mild/Moderate-25 mg/kg/day in divided doses every 12 hours or 20mg/kg/day in divided doses every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours. & 500 mg Capsule. pylori eradication to reduce the risk of duodenal ulcer recurrence in combination with clarithromycin plus lansoprazol as triple therapy.125 mg/1. gonorrhea. Indication: Treatment of respiratory disorder s associated with viscid or excessive mucus and/or productive cough.1gm). Children 2-5 years : 1/2 teaspoonful 3 times daily.2 gm IV Injection (Amoxicillin 1gm and Clavulanic Acid 0.1. bromhexine should be used with caution in patients with a history of gastric ulceration.6 mg/kg/day to 45/6. 135 Mucospel ® Active Ingredient: Bromhexine. Mucospel Tablet: Adults and Children over 10 years : 1-2 tablets 3 times daily. Patients with previous history of Co-amoxiclav or penicillin associated cholestatic jaundice. dosage should be adjusted.2 gm). child 3 months-12 years. Side Effect: Mild and transitory nature.2 g every 6-8 hours. Since mucolytics may disrupt the gastric mucosal barrier. Dosage and Administration: Mucospel Syrup: Adults and Children over 10 years : 2 to 4 teaspoonfuls 3 times daily.5 gm and Clavulanic Acid 0. Contraindication: History of Penicillin hypersensitivity. transient rise in serum aminotransferase values. 0. Diarrhoea. Preparation: 375 Tablet (Amoxicillin 250 mg & Clavulanic Acid 125 mg). Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants). 100 ml Forte Powder for Suspension (Amoxicillin 400 mg & Clavulanic Acid 57. (Amoxicillin 0. vomiting and candidiasis.Product Guide of 2 months to 2 years: 25/3.5 mg/ 5 ml). Drug interactions: Oral contraceptives. sweating and allergic reactions. Children 5-10 years : 1 teaspoonful 3 times daily. Moxaclav 1. indigestion. Side Effect: Gastrointestinal side Effects.d. 60 ml & 100 ml Powder for Suspension (Amoxicillin 125 mg & Clavulanic Acid 31.i.25 mg/ 5 ml). During lactation. trace quantities of Amoxicillin can be detected in breast milk. Contraindication and Precaution: known hypersensitivity or idiosyncratic reaction to bromhexine hydrochloride (or any of the other ingredients in the product). M . Use in Pregnancy and Lactation: Category B.2 IV Injection: 1. nausea. Children 5-10 years : 1/2 tablet 3 times daily. Precaution & Warning: Co-amoxiclav should be used with care in patients on anti-coagulation therapy or with severe hepatic dysfunction. 1gm Tablet (Amoxicillin 875 mg & Clavulanic Acid 125 mg). pseudomembranous colitis. headache. Children below 2 years : 1/4 teaspoonful 3 times daily. 30 mg/kg every 6-8 hours. 625 Tablet (Amoxicillin 500 mg & Clavulanic Acid 125 mg). In patients with moderate or severe renal impairment. Use in Pregnancy & Lactation: Use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. vertigo (dizziness).6 gm IV Inj.4 mg/kg/day b. It is not recommended for breastfeeding mothers unless the potential benefits to the patient are weighed against the possible risk to the infant. Bromhexine has been taken by a large number of pregnant women and women of child bearing age without any proven increase in the frequency of malformations or other direct or indirect harmful Effects on the foetus. 4 mg/5 ml Syrup (100 ml). During the first trimester of pregnancy. Vitamin C and Zinc deficiencies. Vitamin A. Reported side Effects are rare and mild and consistent mainly of diarrhoea. Vitamin A. Folic Acid. adolescents.50 mg (as Ferrous Fumarate USP). E.Cervical syndrome. recommended daily dose should not be exceeded. Iron.00 mg (as Zinc Gluconate USP). Vitamin A 0. Copper. Side Effect: Iron has been associated with gastrointestinal intolerance. Use in Pregnancy and Lactation: During the first trimester of pregnancy. although older children. periarthritis . Cyanocobalamin. larger doses of vitamin A (more than 10 tablets per day) may be teratogenic. khichuri or suji . B6. Indication: deficiencies. Manganese. M Contraindication & Precaution: Hypersensitivity.00 mg (as Ascorbic Acid USP) and Zinc 5. severe specific deficiencies of vitamins or minerals. Potassium and Zinc. Calcium pantothenate. Folic acid. preferably daily over a period of 2-3 months is suggested. Preparation: Tablet. Active Ingredient: Eperisone. Vitamin C & Zinc. Dosage & Administration: For oral administration . B1. treatment with levodopa as pyridoxine decreases the efficacy of levodopa. D. Side-Effect: The only significant side Effect is an expected darkening of infant’s stools. Iodine.16 mg. Vitamin and mineral Dosage & Administration: Orally one Multivit Plus tablet daily for adult and children over 5 years of age or as directed by the physicians. Contraindication & Precaution: Individual with chronic liver disease or pancreatic disease should not take it. pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient.30 mg (as Vitamin A Acetate USP). B2. Nicotinamide. This combination was designed principally for children 6-24 months of age. Folic Acid USP 0. Folic Acid. women in the child-bearing age and pregnant and lactating women may also benefit from the minerals and vitamins in a packet. Preparation: Each gm oral powder contains Iron 12. Product Guide Indication: Prevention and treatment of Iron. Multivit® Plus Active Ingredient: Vitamin A.including semi solid rice. Use of one packet (1 gm of powder).stir 1 gm powder of a packet into any food. Myonil ® Mymix® Active Ingredient: Iron.before serving it to a child. C. Vitamin C 30. Individual with chronic liver disease may have enhanced Iron absorption with the potential for Iron overload. Indication: Improvement of muscular hypertonic symptoms in the following diseases.136 Preparation: 8 mg Tablet. vomiting. allergic reaction including urticaria. vertigo.Product Guide of the shoulder. sequelae to trauma (spinal trauma. etc. Nalidixic acid is contraindicated in the following cases . nausea. Preparation: 2% Nasal Drops. Contraindication & Precaution: In patients with a history of hypersensitivity to Eperisone Hydrochloride. Usual adult dose initially is 1 g every 6 hours for 7 days reducing to 500 mg every 6 hours or as prescribed by the physician. Maintenance: Oral 8. Preparation: 50 mg Tablet. postoperative sequelae (including cerebrospinal tumor). amyotrophic lateral sclerosis. Side Effect: Irritation of nasal mucosa . anorexia. diarrhea. impaired renal or hepatic function. Side Effect: Excessive relaxation. headache. nasal congestion. head injury). Indication: Urinary tract infection. Dosage and Administration: For adults: Usually 3 tablets per day in three divided doses after each meal. Dosage and Administration: Adults . rashes. sneezing and postnasal drip. Nalid ® Active Ingredient: Nalidixic Acid. muscle weakness. stomachache. Contraindication & Precaution: Riskbenefit must be considered during the first trimester of pregnancy and during breast feeding. indigestion. Side Effect: Gastro-intestinal disturbances including nausea. wheezing or tightness of the chest. spinocerebellar degeneration. Use of Nacromin® 2% Nasal Drops is not recommended in children younger than 6 years of age. arthralgia. insomnia.Infants under 3 months. 137 (including the elderly) and children: Initial two drops into each nostril 4-6 times daily. Use in Pregnancy and Lactation: Eperisone Hydrochloride should only be used in pregnant women if the expected therapeutic benefits are evaluated to outweigh the possible risks of treatment. Initial: Oral 13. drowsiness. The drug should not be used during lactation. diarrhoea.75 mg per kg body weight every six hours for one or two weeks. GI disturbances. spastic spinal paralysis. constipation. rhinorrhea. epilepsy. Contraindication & Precaution: Contraindicated in individuals who have shown hypersensitivity to the drug or any ingredient of the preparation. spinal vascular diseases and other encephalomyelopathies. CNS lesions. N Nacromin® Nasal Drops Active Ingredient: Sodium Cromoglycate Indication: Symptomatic prevention and treatment of seasonal or perennial allergic rhinitis. cerebral palsy.25 mg per kg body weight every six hours. Spastic paralysis in the following disease: Cerebrovascular disease. cervical spondylosis. skin rashes. lumbago. Dosage & Administration: Infants and children 3 months of age and over. vomiting. fever. Contraindication:Known hypersensitivity to granisetron. and only on the day(s) chemotherapy is given. anogenital pruritus etc. 1 mg Tablet. Two 1 mg tablets are taken within one hour of irradiation. dyspepsia. nausea. Use in Pregnancy and Lactation: This drug should be used in pregnancy only if clearly needed. Naurif Tablet: Emetogenic chemotherapy: 2 mg once daily or 1 mg twice daily. Side Effect: Headache. Pregnancy: Pregnancy category B. Prevention and treatment of postoperative nausea and vomiting. therapy including high dose cisplatin. Nursing Mother: Caution should be exercised when granisetron is administered to a nursing mother. including high dose of cisplatin. Contraindication & Precaution: Hypersensitivity. Radiation: 2 mg once daily. . asthenia. Dosage & Administration: Naurif Injection: Chemotherapy Induced Nausea and Vomiting: Adults: 10 mcg/ kg administered intravenously within 30 minutes before initiation of chemotherapy. anxiety. Indication: Naurif Injection: Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. Preparation: 1 mg/ml Injection. Paediatric patients 2 to 16 years of age:10 mcg/kg. This drug may be used in pregnancy only if clearly needed. diarrhea. abdominal pain. Product Guide ml and administered as a slow intravenous injection (over 30 seconds). insomnia. eczematoid dermatitis. vomiting. including total body irradiation and fractionated abdominal radiation. Nalidxic acid excreted into milk in small amounts. Preparation: 500 mg Tablet and 300 mg/5 ml Powder for Suspension. constipation. Dosage & Administration: A thin film to be applied 2 to 4 times daily. Drug Interaction: This drug should not be used with the following medications because very serious interactions may occur: certain cancer chemotherapy (alkylating agents such as melphalan). eczema. neurodermatitis. atopic or contact stasis and infections. overgrowth of non-susceptible organisms including fungi. Administered only on the days(s) chemotherapy is given. Treatment of Postoperative Nausea and Vomiting: Adults: Single dose of 1 mg of Naurif should be diluted to 5 Nebanol ® Active Ingredient: Neomycin Sulphate and Bacitracin Zinc.138 phototoxicity. dizziness. nephrotoxicity. N Naurif ® Active Ingredient: Granisetron. Indication: Topical bacterial infections. Nausea and vomiting associated with radiation. It is compatible with breast feeding. Naurif Tablet: Nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy. + 5000 I. Indication: In combination with other antiretroviral agents is indicated for the treatment of HIV infection. Dosage & Administration: A thin film to be applied one to three times daily. burns or skin grafts. glucosegalactose malabsorption syndrome. Bacitracin Zinc and Polymyxin B Sulphate. pyoderma. (5 mg + 500 I. liquid sugar (67. Dosage & Administration: Adults : 1250 mg (five 250 mg tablets) twice daily or 750 mg (three 250 mg tablets) three times Nectar ® Active Ingredient: Glycerol. Children 1-5 years: One 5 ml spoonful.5%).)/gm Ointment. sycosis barbae. The dose should be repeated three or four times a day as required. Contraindication & Precaution: Hypersensitivity to any of the ingredients or hereditary fructose intolerance. secondary infected skin lesions of scabies. Not recommended for children below three months.5 .)/gm Powder. Not recommended for neonates.U. but is not considered to constitute a hazard during these periods and used widely without any ill consequence. or sucrase-isomaltase deficiency.1 spoonful).5 ml (1/2 . It also assists in relieving productive cough. Preparation: (3. Use in Pregnancy and Lactation: Not recommended in pregnancy and lactation. Preparation: 100 ml linctus. pediculosis. Side Effect: This medicine is unlikely to cause side Effects unless the patient is allergic to the ingredients. ototoxicity. Contraindication & Precaution: Hypersensitivity reaction. tinea pedis and contact and allergic dermatitis.U.Product Guide Adverse Reaction: Allergic reaction. Diabetics should take note of the carbohydrate content of this product. chronic varicose or other indolent ulcers. Children 3 month-under 1 year:2. Preparation: (5 mg + 250 I. Dosage & Administration: Adults including the elderly and children over 5 years: Two 5 ml spoonfuls. Nebanol Plus® Active Ingredient: Neomycin Sulphate. furuncles. Use in Pregnancy & Lactation: The safety of this product during pregnancy and lactation has not been established. impetigo and acne. irritating coughs .)/gm Ointment.5 mg + 400 I.U. Indication: Relief of dry. 139 and sore throats. Indication: Infected wounds. carbuncles. N Nelvir® Active Ingredient: Nelfinavir.U. Drug Interaction: Dihydropyridine calcium channel blockers. Nelfinavir should be used during pregnancy only if clearly needed. amiodarone. dorsocervical fat enlargement (buffalo hump). creatine phosphokinase. hepatitis and pancreatitis. Indication: Duodenal ulcer. redistribution/ accumulation of body fat. pimozide. midazolam. Gastric ulcer.asthenia. accidental injury. Injection: 50 mg.140 daily. thrombocytopenia. SGOT. post operative ulcer. increases in alkaline phosphatase. Polymyxin B Sulphate and Pramoxine HCl. Fat redistribution/ accumulation of body fat including central obesity. 75 mg/5 ml Syrup and 50 mg/2 ml Injection. Maintenance therapy: 150 mg at night. Use in Pregnancy and Lactation: Pregnancy Category B. & Precaution: N Side Effect: Infrequent Rash. including spontaneous skin hematomas and hemarthrosis. amylase. Preparation: 250 mg Tablet. rifampin. Leukopenia. It is best avoided by nursing mothers.allergic reaction. abdominal pain. malaise. sildenafil. Preparation: 150 mg and 300 mg Tablet. SGPT and gamma glutamyl transpeptidase has been noticed occasionally. Injection is not indicated for children. dyspepsia. . Children: 2 mg/kg-4 mg/kg twice daily to a maximum 300 mg/day. Caution should be exercised when administering this drug to patients with hepatic impairment. epigastric pain. facial wasting. Nepranol® Active Ingredient: Neomycin Sulphate. mothers should be instructed not to breast-feed if they are receiving Nelfinavir. Neotack® Active Ingredient: Ranitidine. There have been reports of increased bleeding. Ergot Derivatives. ZollingerEllison syndrome. Contraindication & Precaution: In patients with clinically significant hypersensitivity. Side Effect: Diarrhea. gastrointestinal bleeding. slow IV every six to eight hourly. didanosine. and “cushingoid appearance” have been observed in patients receiving antiretroviral therapy. Because of both the potential Product Guide for HIV transmission and the potential for serious adverse reactions in nursing infants. anorexia. headache. Use in Pregnancy & Lactation: Should be prescribed only if clearly needed. in patients with hemophilia type A and B treated with protease inhibitors. Reflux oesophagitis. quinidine. Contraindication Hypersensitivity. peripheral wasting. 45 to 55 mg/kg twice daily or 25 to 35 mg/kg three times daily. HMG-CoA reductase inhibitors. Mendelson’s syndrome Dosage & Administration: 150 mg twice daily or 300 mg single dose. triazolam. mental confusion and hallucination. lactic dehydrogenase. fever. breast enlargement. Pediatric Patients (2-13 years) : In children 2 years of age and older.immunosuppressants . Pyridoxine (Vit-B6). Neuralgia. particularly Neomycin sulphate. Indication: Indicated in low back pain and in the deficiency of the relevant vitamins including Polyneuropathy of any origin such as. may cause cutaneous sensitization. Exercise caution when applying Nepranol to a nursing mother. May be covered with a sterile bandage Contraindication: Neomycin. Preparation: 10 gm Cream. Pramoxine or any other components of this product. Injection : Preferably injected intramuscularly (deep intragluteal). Side Effect: Topical antibiotics. Polymyxin B and Pramoxine HCl during pregnancy only if the potential benefit justifies the potential risk to the fetus.Diabetic. Pyridoxine Hydrochloride 200 mg. Pyridoxine Hydrochloride 100 mg. In severe cases 1 ampoule daily until the acute symptoms subside. Lumbago. Use in Pregnancy and Lactation: Use Neomycin. (Thiamine Mononitrate 100 mg. Dosage and Administration: Tablet : 1 to 3 tablets daily or as directed by the physician. Drug Interaction: No drug interactions have yet been reported. Use in Pregnancy and Lactation: Sufficient data yet not availalble in this respect. Herpes Zoster. Cyanocobalamin (VitB12). no common side Effects have been reported with this product.Product Guide Indication: First aid antibiotic. 2 or 3 ampoules per week. Polymyxin B. 141 Syndrome. Dosage & Administration: Clean the affected area. Cyanocobalamin 200 mcg)/ Tablet. Alcoholic or Toxic neuropathies. Trigeminal Neuralgia Supportive treatment in facial paresis. N Neuro-B® Active Ingredient: Thiamine (Vit-B1). Cervical . Contraindication and Precaution: Patients on Levodopa therapy and hypersensitivity to any of the active ingredients. Sciatica. Cyanocobalamin 1000 mcg)/ 3 ml Injection. Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. applies a small amount of product (an amount equal to the surface area of the tip of a finger). Side Effect: Well tolerated. Mayalgia. Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin. Shoulder-arm syndrome. Neuritis. When used in small doses. Intercostal neuralgia. The manifestations of sensitization to topical antibiotics are usually itching and reddening. Few allergic responses may be seen in rare cases. Preparation: (Thiamine Mononitrate 100 mg. For milder cases and follow-up therapy. Polymyxin B and Pramoxine HCl cream should not be administered to individuals who are hypersensitive to Neomycin. It is not known whether this drug is excreted in breast milk. It is also indicated for the adjunctive therapy for adult patients with partial onset seizures. Drug Interaction: Thyroid extract. mental retardation in children. anxiety and sleep disturbances. Neurolin® Active Ingredient: Pregabalin. phenyton. carbamazepine.vertigo. behaviour and psychotic problems in old age. The total daily dose should be divided and given either two or three times daily. or 50 mg three times a day). Adjunctive therapy for adult patients with partial onset seizures: Pregabalin (Neurolin) at doses of 150 to 600 mg/ day has been shown to be Effective as adjunctive therapy in the treatment of partial onset seizures in adults. vomiting. or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/ min. In general. or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. irritability. Dosing should begin at 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Indication: Cerebral vascular accidents and cerebral insufficiencies. Management of Fibromyalgia: The recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day. N Side Effect: Nervousness.trembling and sexual stimulation have occasionally been reported. the dose may be increased to a maximum dose of 600 mg/day. hepatic impairment and those under 16 years of age. Dosing should begin at 75 mg two times a day.142 Product Guide for the management of fibromyalgia. Dosage & Administration: Neuropathic pain associated with diabetic peripheral neuropathy: The maximum recommended dose of Pregabalin (Neurolin) is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Indication: Neurolin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy and management of post herpetic neuralgia. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 Neurolep® Active Ingredient: Piracetam. agitation. Based on individual patient response and tolerability. Nausea. Contraindication and Precaution: Severe renal insufficiency (creatinine clearance < 20 ml/min). headache. Preparation: 800 mg Tablet & 500 mg/5ml Solution. Dosage and Administration: Adults: One tablet (800 mg) 3 times a day. Children: 50 mg/kg of body weight in 3 divided doses. Post herpetic neuralgia:The recommended dose of Pregabalin (Neurolin) is 75 to 150 mg two times a day. diarrhea and stomachache. clonazepam. phenobarbitone and sodium valporate. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. It can be used . memory deficits. it is recommended that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day. Healing of Erosive Esophagitis. So it should be used in nursing mother only if there is a clear benefit over the risk. N Nexum® Active Ingredient: Esomeprazole. headache and diarrhea. and abnormal thinking. Discontinuation of Pregabalin without tapering may produce insomnia. present in the milk of rats. Indication: Nexum is indicated for the treatment of . weight gain. So it should only used if potential benefit justifies the potential risks to the fetus. dry mouth. Use in Pregnancy and Lactation: Pregnancy: Pregnancy category C. Creatinine kinase may be elevated if treated with Pregabalin. Side Effect: The most common side Effects include dizziness. however.Gastroesophageal Reflux Disease (GERD). It should be discontinued rapidly if myopathy is diagnosed or suspected or if creatinine kinase is elevated markedly. Nursing mother: It is not known if pregabalin is excreted in human milk. Maintenance of healing of Erosive Esophagitis. 143 Contraindication & Precaution: Pregabalin (Neurolin) is contraindicated in patients with known hypersensitivity to Pregabalin or any of its components. Risk Reduction of NSAIDassociated gastric ulcer & H. blurred vision. Use in Children: The safety and efficacy of pregabalin in paediatric patients have not been established. Dosage & Administration: Tablet and capsule: Recommended adult dosage schedule of Esomeprazole is Indications Dose Frequency Gastroesophageal Reflux Disease (GERD) Healing of erosive esophagitis 20 mg or 40 mg Once daily for 4 to 8 weeks* . nausea. Symptomatic Gastroesophageal Reflux Disease (GERD). it is. So it should be tapered gradually over a minimum of 1 week rather than discontinued abruptly. somnolence. edema. 75 mg & 150 mg Capsule.Product Guide mg/day). pylori eradication (Triple therapy). Preparation: 50 mg. 144 Maintenance of healing of 20 mg erosive esophagitis Product Guide Once daily** Symptomatic GERD 20 mg Once daily for 4 weeks *** Once daily for up to 6 months** Twice daily for 10 days Twice daily for 10 days Twice daily for 10 days Risk Reduction of NSAID. • If symptoms do not resolve completely after 4 weeks. The reconstituted solution may be stored at room temperature (up to 30oc) for a maximum 12 hours prior to dilution. an additional 4-8 weeks treatment may be considered.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. an additional 4 weeks of treatment may be considered.9% Sodium Chloride Injection to the vial containing powder.9% Sodium Chloride Injection or Lactated Ringer’s Injection to a final volume of 50 ml. Direction for use of IV Infusion Esomeprazole IV 40 mg should be given as an intravenous infusion over a period of 10 to 30 minutes. gastric ulcer. After reconstitution the injection should be given slowly over a period of at least 3 minutes. gastrointestinal lesions refractory to H2 blockers. • The majority of patients are healed within 4 to 8 weeks. Esomeprazole injection 40 mg should be given as a slow intravenous injection.9% Sodium Chloride Injection and further diluted (admixed) with 5% Dextrose Injection or 0. The solution for IV injection is obtained by adding 5 ml 0.20 mg or 40 mg associated gastric ulcer H. Half of the IV injection should be used when 20 mg to be administered. • Controlled studies did not extend beyond 6 months. The reconstituted solution may be stored at o room temperature (up to 30 c) for a maximum 12 hours. pylori eradication (Triple therapy) Esomeprazole Amoxicillin Clarithromycin 20 mg 1000 mg 500 mg N Paediatric use (12 years and older) Short term treatment of GERD: 20 mg or 40 mg once daily for up to 8 weeks. Use only freshly prepared solution. The admixed solution may be stored at room temperature . Injection Duodenal ulcer. Zollinger-Ellison syndrome Reflux esophagitis 40 mg per day intravenously 20-40 mg per day intravenously Direction for use of IV Injection Esomeprazole lyophilized powder and 0. Esomeprazole IV should be reconstituted with 5 ml of 0. For patients who do not heal after 4-8 weeks. Anti-bacterials. prophylactic nitrate therapy or additional nifedipine may be of benefit. advanced aortic stenosis. Dosage & Administration: Adult: Hypertension:One capsule daily swallowed with water. hypotension. Antiepileptics. beta-blockers. inflammatory bowel disease. Side-Effect: Side Effects reported with Esomeprazole include headache. hypotensive effect. Angina: One capsule every 12 hours swallowed with water. photosensitivity and few cases of jaundice have been reported. Contraindication & Precaution: Esomeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation. If necessary. Angina. Muscle relaxants. a decision should be made whether to discontinue nursing or to discontinue the drug. nursing mothers. eye pain. depression. Dosage and Administration: twice daily with food. gravitational oedema. nausea. chewed or broken up. Enhanced. Antipsychotics. Anti-arrhythmics. gum hyperplasia. Indication: Management of hypertension & chronic stable angina pectoris where therapy with either a calcium channel blocker or a beta-blocking drug proves inadequate. Preparation: 20 mg Tablet & Capsule. Ulcer healing drugs. diarrhea and abdominal pain. N Nidipro® Active Ingredient: Nifedipine + Atenolol. This drug should be used during pregnancy only if clearly needed.Product Guide (up to 30oc) and must be used within 12 hours when reconstituted with 0. 145 should be swallowed whole and should not be bitten. flushing. Where additional efficacy is necessary. Drug Interaction: ACE inhibitors. Use in Pregnancy: It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Because Esomeprazole is likely to be excreted in human milk.‘B’. Cyclosporin. Use in Pregnancy & Lactation: US FDA Pregnancy Category . Indication: Hypertension. Preparation: 20 mg SR Tablet. increased frequency of micturition. 20 mg Contraindication & Precaution: Cardiogenic shock. Nidipine® SR Active Ingredient: Nifedipine. . 40 mg Tablet & Capsule and 40 mg IV Injection. Side Effect: Headache. rash.9% Sodium Chloride Injection or Lactated Ringer’s Injection and within 6 hours when reconstituted with 5% Dextrose Injection. taking into account the importance of the drug to the mother. It should be used with caution in patient whose cardiac reserve is poor. Exclude the possibility of malignancy when gastric ulcer is suspected and before treatment for dyspepsia. tremor. GI obstruction. the dosage may be increased to 1 capsule every 12 hours. lethargy. Use of topical preparations with high concentrations of alcohol. dizziness. purpura. Use in Pregnancy and Lactation: Tretinoin is contraindicated in pregnancy or suspected pregnancy. women capable of childbearing or during pregnancy or during lactation. severe peripheral arterial circulatory disturbances. mouth and mucous membranes. hypotension. gastrointestinal disturbance. eczematous skin. N Nimocal ® Nilac® Active Ingredient: Tretinoin. astringents and perfume should be avoided. nostrils. If contact in these areas occurs. Contraindication & Precaution: Known hypersensitivity to either active component or any other excipient or other dihydropyridines. Preparation: 10 gm Gel. Use in Pregnancy and Lactation: Contraindicated in women capable of childbearing or during pregnancy or during lactation. hyperpigmentation. pregnancy or suspected pregnancy. Drug Interaction: Particular caution should be exercised in using preparations containing peeling agents (i. patients with Prinzmetal’s angina & first degree heart block. Contraindication and Precaution: Allergic reaction. peeling and sensation of warmth. uncontrolled heart failure. The drug should be avoided by breast feeding mothers. menthol. resorcinol. impotence. Exposure to sunlight should be avoided or minimised during the use of Tretinoin.146 Elderly: Dosage should not exceed 1 capsule daily in hypertension or 1 capsule twice daily in angina. benzoyl peroxide or salicylic acid). patients with clinically significant aortic stenosis. cardiogenic shock. edema. Side Effect: Flushing. Side Effect: True allergic contact dermatitis irritation. Use in Children: Safety and effectiveness in pediatric patients have not been established. Indication: Acne vulgaris. secondary prevention of myocardial infarction. especially during initial therapy. careful washing with water is recommended. patients with marked renal impairment. Active Ingredient: Nimodipine. sick sinus syndrome. spices or lime such as shaving lotions. fatigue. Avoid contact with eyes. eyelids. familial history of cutaneous epithelioma. untreated phaeochromocytoma. headache. Bradycardia. Indication: For the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms regardless of their post- .e. erythema. metabolic acidosis. Preparation: Nifedipine 20 mg + Atenolol 50 mg Capsule Product Guide Dosage and Administration: Once or twice a day. sulfur. second or third degree heart block. The metabolism of nimodipine is decreased in patients with impaired hepatic function. Alprazolam is also contraindicated in pregnancy. Common cold and Sinusitis.05% in each nostril twice daily. antihistaminics. flushing. Nimodipine may pass into breast milk but has not been reported to cause problems.Product Guide ictus neurological condition. Contraindication and Precaution: Hypersensitivity to Alprazolam or other benzodiazepines. Precaution: Blood pressure should be carefully monitored during treatment with nimodipine based on its known pharmacology and the known Effects of calcium channel blockers. slow heartbeat.constipation.025% in each nostril twice daily in the morning and evening.25 mg & 0. Preparation: 0. N Nocon® Active Ingredient: Oxymetazoline.stomach pain. caution is advised. Use in Pregnancy & Lactation: Large doses of nimodipine have been shown to cause birth defects in animals. Uses in Pregnancy & Lactation: Safety in pregnancy has not been established. Drug Interaction: AIprazolam produces additive CNS depressant Effects when co-administered with other psychotropic medications.25 mg (250 mcg) increments . Side Effect: Headache. or those with organic brain syndrome. heartburn. coordination difficulties with dizziness. Children 2-5 years of age : 2 to 3 drops of Nocon® 0.5 mg Tablet. depression etc. Human studies have not been done. Elderly and debilitated patients.25 mg (250 mcg) given 2 or 3 times daily. upset stomach. fast heartbeat. Preparation: 30 mg Tablet. increases may be made in 0. Nixalo® Active Ingredient: Alprazolam Indication: • Anxiety disorder • Generalized Anxiety Disorder (GAD) • Panic disorder with or without agoraphobia Dosage and Administration: For Adults : Initially 0. if required. anticonvulsants. have been found to be prone to the CNS depressant activity of benzodiazepines even after low doses. The most frequently reported are drowsiness. Oxymetazoline HCl should generally be used for no longer than 3-5 days. Dosage and Administration: Adults and children 6 years of age : 2 to 3 drops of Nocon 0. in the morning and evening. Indication: Relief of nasal congestion associated with acute and chronic rhinitis. Oral therapy should be commence within 96 hours of the subarachnoid hemorrhage. ethanol and other drugs which themselves produce CNS depression. therefore its use is not recommended. dizziness. Dosage and Administration: Initial dose is 60 mg in every four hours interval for 21 consecutive days. 147 according to the severity of symptoms and patient response. Side Effect: Not serious. dry mouth. Indication: Norpill 1 is an emergency contraceptive that can be used to prevent pregnancy following unprotected intercourse or a known or suspected contraceptive failure. Drug Interaction: Causes hypertensive crisis if used simultaneously with MAO inhibitor or Tricyclic antidepressant. dizziness. like progestin-only contraceptives. Contraindication & Precaution: Levonorgestrel should not be given to pregnant women. paraesthesia and dysaesthesia. if the last menstrual period was abnormal in timing or character. muscle weakness.148 Contraindication & Precaution: MAO inhibitor. a second dose has been shown to be Effective within 2 hours of the initial dose. subsequent attacks can be treated with 5 mg doses of Nomi (Zolmitriptan). sneezing. If menstrual bleeding is overdue. warm sensation. neck. Patients sensitive to other nasal decongestants may be sensitive to this medication also. Dosage & Administration: One Norpill 1 tablet should be taken orally as soon as possible within 72 hours after unprotected intercourse. pregnancy should be excluded before treatment is given. uncontrolled hypertension. drying of the nostrils. Contraindication: Known hypersensitivity. nausea. or if pregnancy is suspected for any other reason. Precaution and Warning: WolffParkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathways.5 mg Tablet.05% Nasal Drops for adults. Use in Pregnancy and Lactation: Safe in the third trimester of a normal pregnancy. Tricyclic antidepressant. N Preparation: 0. and vice versa. . Side Effect: Stinging. heaviness. limbs and chest (with no evidence of ischaemic changes on ECG). and altered taste.025% Paediatric Nasal Drops for children. TM Nomi ® Active Ingredient: Zolmitriptan. Dosage and Administration: 2. Product Guide Drug Interaction: It is recommended that patients should leave at least 6 hours between taking an ergotamine preparation and starting Zolmitriptan.5 mg if symptoms persist or return within 24 hours. Norpill 1 Active Ingredient: Levonorgestrel. asthenia. tightness or pressure may occur in the throat. Preparation: 2. increased nasal discharge. Concomitant administration of other 5HT1D agonists within 12 hours of Zolmitriptan treatment should be avoided. Levonorgestrel. does not protect against HIV infection (AIDS) and other sexually transmitted diseases. Indication: Migraine with or without aura. somnolence. burning. 0. and myalgia. Caution should be exercised when administering to a nursing mother. Side Effect: The most commonly reported adverse drug reaction was dry mouth. Levonorgestrel may increase the risk of cyclosporin toxicity due to possible inhibition of cyclosporin metabolism.Levonorgestrel is secreted into breast milk. Contraindication and Precaution: Tiotropium is contraindicated in patients with a history of hypersensitivity to atropine or its derivatives. ritonavir. or to any component of this product. increased heart rate. or headache may occur.changes in vaginal bleeding. and urinary retention.. once-daily. phenytoin. and pharmacokinetic data are not available for this population. Dosage and Administration: Adults and adolescents 12 years and older : The recommended dosage of Tiotropium bromide is the inhalation of 2 puffs of Norvent Inhaler once daily. primidone. swelling. urinary difficulty. rifampicin. breast tenderness. carbamazepine. trouble breathing. prostatic hyperplasia or bladder-neck obstruction and should be used with caution in patients with any of these conditions. The coadministration of Tiotropium with other anticholinergic-containing drugs (e. Drug Interaction: The metabolism of levonorgestrel is enhanced by concomitant use of liver enzyme inducers. Preparation: 1. Tiotropium may potentially worsen symptoms and signs associated with narrow-angle glaucoma. The potential exposure of an infant to levonorgestrel can be reduced if the breastfeeding woman takes the tablets immediately after feeding and avoids nursing following each tablet administration. Uses in Pregnancy & Lactation: Pregnancy Category C : Tiotropium should be used during pregnancy only if the N Norvent TM Inhaler . Drugs suspected of having the capacity to reduce the efficacy of levonorgestrel-containing medication includes: barbiturates. Tell your doctor immediately if any of these rare but very serious side Effects occur: lower abdominal pain. A very serious allergic reaction to this drug is rare. diarrhea. Side Effect: Nausea/vomiting. abdominal pain. Drug Interaction: Tiotropium has been used concomitantly with other drugs commonly used in COPD without increase in adverse drug reactions. 149 Indication: Norvent is indicated for the long-term. rifabutin and griseofulvin. severe dizziness. including chronic bronchitis and emphysema. Use in Pregnancy & Lactation: It should not be given to pregnant women and it will not interrupt the pregnancy. blurred vision. herbal medicines containing Hypericum perforatum (St Johns’ Wort).dizziness. glaucoma. Symptoms of a serious allergic reaction: rash. maintenance treatment of bronchospasm associated with Chronic Obstructive Pulmonary Disease (COPD). ipratropium) has not been studied and is therefore not recommended. itching. As an anticholinergic drug. included constipation. Other reactions.Product Guide Active Ingredient: Tiotropium. Use in Children: This product is not intended for use in pediatric populations. including ipratropium.5 mg Tablet.tiredness.g. headache. Product Guide Active Ingredient: Bromfenac. dysentery. Indication: Ocufen 0. biliary.09% Eye Drops Ofkof ® . Side Effect: The most commonly reported adverse experiences are: abnormal sensation in eye. Preparation: Inhaler : Tiotropium 9 mcg/ puff. mild cystitis. Injection : 1 ampoule (5 mg) three times daily. colonopathyes. Norvis TM Active Ingredient: Methylsulphate. treatment should start 24 hours after surgery and should continue for 2 weeks Children: Use and dose must be determined by the doctor. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. conjunctival hyperemia. O Dosage and Administration: Tablet : 2-6 tablets (100-300 mg) daily in divided doses. Dosage & Administration: Adults: 1 drop to the problem eye 2 times a day. biliary colic. Preparation: 50 mg Tablet. eye pain.09% Eye Drops is indicated for the treatment of postoperative inflammation and the reduction of ocular pain in patients who have undergone cataract extraction. Use in Pregnancy & Lactation: US FDA Pregnancy Category C. May be used in lactating mother only if it is clearly needed by the assessment of risk benefit ratio. eye redness. Contraindication & Precaution: Bromfenac ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredient in the formulation. through Intravenous route slowly or Intramuscular route. enterocolitis. Use in Pregnancy & Lactation: May be used in pregnancy only if it is clearly needed by the assessment of risk benefit ratio. 5 mg/2 ml Injection. disorder of prostate or urinary bladder. Ocufen® 0. eye irritation (including burning/stinging). eye pruritus. Preparation: 5 ml sterile solution. & spasmodic dysmenorrhoea. 120 puffs. cholecystytis. Use in Children: Safety and efficacy in pediatric patients have not been established yet.150 potential benefit justifies the potential risk to the fetus. Contraindication : Glucoma or where acute pain of eyeball with vision disturbance. Caution should be exercised when Bromfenac ophthalmic solution is administered to a nursing woman. Side Effect: Very rare. diarrhoea. urinary and gynaecological disease such as gastroenteritis. and iritis. Tiemonium Indication: Pain in gastrointestinal. gastro-intestinal disturbances. 151 Use in Pregnancy and Lactation: Caution should therefore be exercised by balancing the potential benefits of treatment of the mother against any possible hazards to the developing fetus. within 2 weeks of stopping such treatment. Preparation: (Dextromethorphan Hydrobromide 10 mg. Indication: Symptomatic relief of upper respiratory tract disorders accompanied by non-productive cough which benefits from the administration of a nasal decongestant. 2-6 years : 1/2 teaspoonful three times daily or as directed by the physician. 6-12 years: 1 teaspoonful three times a day.the recommended oral dosage is one 8mg Ofran tablet or 10ml of Ofran oral O . hallucination. Side Effect: Dizziness. severe hypertension or severe coronary artery disease. diabetes. As with other sympathomimetic agents caution should be exercised in patients with hypertension. heart disease. hyperthyroidism. nose and throat. methyldopa. dryness of mouth. Pseudoephedrine and Triprolidine. Central nervous system (CNS) depression or excitation.Product Guide Active Ingredient: Dextromethorphan. In case of moderately emetogenic chemotherapy the oral dose is one 8 mg Ofran (Ondansetron) tablet or 10 ml of Ofran (Ondansetron) oral solution given twice daily Pediatric patients.25 mg)/5 ml Syrup. Pseudoephedrine Hydrochloride 30 mg and Triprolidine Hydrochloride 1. urinary retention. tricyclic antidepressants. a histamine H1 receptor antagonist and an antitussive combination. This combination may cause drowsiness and impair performance in tests of auditory vigilance. Children : over 12 years: 2 teaspoonful three times a day. Sleep disturbance. Drug Interaction: Decongestants.for pediatric patients 4 through 11 years of age the dosage is one 4mg Ofran tablet or 5ml of Ofran solution should be administered 3 times a day for 1 to 2 days after completion of chemotherapy. Contraindication and Precaution: Known hypersensitivity to Dextromethorphan. Radiotherapy induced nausea and vomiting: Adult. Pseudoephedrine or Triprolidine. guanethidine. Dosage and Administration: Adults : 2 teaspoonful three times a day. in persons under treatment with monoamine oxidase. Skin rashes with or without irritation. appetite suppressants and amphetamine like psychostimulants or with monoamine oxidase inhibitors. tachycardia. Ofran® Active Ingredient: Ondansetron Indication: Ofran is indicated for • Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy • Prevention of nausea and vomiting associated with radiotherapy • Prevention of post operative nausea and vomiting Dosage & Administration: Prevention of chemotherapy induced nausea & vomiting (CINV): Adult-The recommended adult oral dosage of Ofran (Ondansetron) is 24 mg given as three 8 mg tablets in highly emetogenic chemotherapy. alphaadrenergic blocking agents. elevated intraocular pressure and prostatic enlargement. The use of Ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension. Post operative nausea & vomiting (PONV): Adult. Olmesartan Indication: For the treatment of hypertension. Dosage & Administration: Dosage must be individualized. Ondansetron is not a drug that stimulates gastric or intestinal peristalsis.3ml. Vitamin E. Product Guide Active Ingredient: Cod Liver Oil BP 0. It may be used alone or in combination with other antihypertensive agents.The usual recommended starting dose of Olmesartan is 20 mg once daily when used as monotherapy in patients who are not volume-contracted. Indication: Vitamin A & Vitamin D deficiency. Contraindication & Precaution: Ondansetron is contraindicated in patients with known hypersensitivity to the drug. Use in Pregnancy & Lactation: In pregnancy: Pregnancy category B. It should not be used instead of nasogastric suction.the recommended dosage is 16 mg given as two 8mg Ofran tablets or 20 ml of Ofran oral solution 1hour before induction of anesthesia. Doses above 40 mg do not appear to have Olicod ® . 60 mg Suppository . 4 mg/5 ml (50 ml) solution. For patients requiring further reduction in blood pressure after 2 weeks of therapy.152 solution given 3times daily. Eicosapentaenoic Acid (EPA). Hypersensitivity reactions have been reported in patients who have exhibited hyper sensitivity to other 5-HT3 receptor antagonists. Patients with chronic renal failure should be suggested Cod Liver Oil with caution. Caution should be exercised when Ondansetron is administered to nursing mother. Dosage & Administration: 2-6 Capsules daily or as directed by the physician. 8 mg/4ml Injection. Contraindication & Precaution: Hypervitaminosis of Vitamin A. Vitamin D3. In lactation: Ondansetron excretes in milk of lactating animals. Use in Pregnancy & Lactation: Recommended by the consultation with physician Preparation: Liquid filled hard gelatin capsule. Preparation: 8 mg Tablet. Docosahexaenoic Acid (DHA). D or E and hypersensitivity to any of the ingredients in this preparation. O Olmecar TM Active Ingredient: Medoxomil. Dosage adjustment for patients with impaired hepatic functionThe total daily dose of 8mg should not be exceeded. the dose of Olmesartan may be increased to 40 mg. Which has -Vitamin A. So the drug should be used in pregnancy only if clearly needed. rhinitis and sinusitis.Product Guide greater Effect. influenzalike symptoms. Because of the Hydrochlorothiazide component. Contraindication & Precaution: Olmesartan is contraindicated in patients who are hypersensitive to any component of this product. 153 Indication: Indicated for the treatment of hypertension. If large doses of hydrochlorothiazide have been used as monotherapy and volume depletion or hyponatremia is present. Consideration should be given to reducing the dose of Hydrochlorothiazide to 12. hematuria. pharyngitis. Depending on the blood pressure response. If a patient is taking Hydrochlorothiazide. Twice-daily dosing offers no advantage over the same total dose given once daily. hypertriglyceridemia.5 mg and later titrated to 25 mg once daily. caution should be used when adding Olmesartan or switching to Olmecar Plus tablet. Use in Pregnancy & Lactation: Pregnancy Categories: C (first trimester) and D (second and third trimesters). but Olmesartan is secreted at low concentration in the milk of lactating rats. The antihypertensive Effect of Olmecar Plus tablet is related to the dose of both components over the range of 10 mg/12. This fixed dose combination is not indicated for initial therapy. Because of the potential for adverse Effects on the nursing infant. bronchitis. The following adverse events occurred in placebo controlled clinical trials at an incidence of more than 1% of patients treated with Olmesartan. Olmesartan may be added starting with a dose of 20 mg once daily and titrated to 40 mg. Preparation: 20 mg & 40 mg Tablet. Dosage & Administration: The dose of Olmecar Plus tablet is one tablet once daily. a decision should be made whether to discontinue nursing or discontinue the drug. Side Effect: Treatment with Olmesartan was well tolerated.5 mg to 40 mg/25 mg. + Hydrochlorothiazide. creatine phosphokinase increased. this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. with an incidence of adverse events similar to placebo. the dose may be titrated at intervals of 2-4 weeks. Hydrochlorothiazide may be added starting with a dose of 12. as marked decreases in blood pressure may occur. hyperglycemia. but also occurred at about the same or greater incidence in patients receiving placebo: back pain. diarrhea. for inadequate blood pressure control. Nursing Mothers: It is not known whether Olmesartan is excreted in human milk. Contraindication & Precaution: This combination tablet is contraindicated in patients who are hypersensitive to any component of this product. taking into account the importance of the drug to the mother. Use in Children: Safety and Effectiveness in pediatric patients have not been established. If blood pressure is not controlled by Olmesartan alone.5 mg before adding Olmesartan. Olmecar Plus tablet may be administered with other antihypertensive agents. headache. A patient whose blood pressure is inadequately controlled by Olmesartan or Hydrochlorothiazide alone may be switched to once daily Olmecar Plus tablet. Dosing should be individualized. O Olmecar Plus TM Active Ingredient: Olmesartan Medoxomil . . chest pain. Thiazides appear in human milk. Side Effect: Paresthesia. Indication: For the temporary relief of pain due to minor injury or irritation of the mouth and gums like. abdominal pain. creatine phosphokinase increased. edema and secondary infection. Contraindication and Precaution: Hypersensitivity.154 Side Effect: This combination tablet has been evaluated for safety in 1.toothache. Use in Pregnancy & Lactation: Pregnancy: Pregnancy Categories C (first trimester) and D (second and third trimesters). minor dental procedures. rash etc. gastroenteritis. arthralgia. Events generally were mild. It was well tolerated. Product Guide Indication: Inflammatory dermal infections like tinea pedis. tinea corporis etc. transient and had no relationship to the dose of this combination tablet. Use in Pregnancy and Lactation: The cream should only be used in pregnancy. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their large skin surface to body mass ratios. vertigo.243 hypertensive patients. Dosage and Administration: Twice a day for 2-4 weeks. taking into account the importance of the drug to the mother. Preparation: (0. coughing. arthritis. peripheral edema. GGT increased. Use in Children: Not recommended under 12 years. O Orogel TM Active Ingredient: Benzocaine. burning and dry skin. Preparation: Olmesartan Medoxomil 20 mg + Hydrochlorothiazide 12.5 mg + 10 mg) Cream. canker sores. facial rosacea.5 mg. hyperglycemia. if the benefit justifies the potential risk to the fetus. acne vulgaris. rash. This combination drug should not be used during pregnancy. systemic absorption produces HPA axis suppression. but Olmesartan is secreted at low concentration in the milk of lactating rats. perianal and genital pruritus. sore gums. diarrhoea. SGOT increased. Dosage and Administration: Apply to the affected area up to 4 times daily or Oni® Active Ingredient: Betamethasone Dipropionate & Clotrimazole. dentures. back pain. Use in Children: Safety and Effectiveness in pediatric patients have not been established. perioral dermatits. a decision should be made whether to discontinue nursing or discontinue the drug. braces. urinary tract infection. Nursing Mothers: It is not known whether Olmesartan is excreted in human milk. myalgia. with an incidence of adverse events similar to placebo. Because of the potential for adverse Effects on the nursing infant. napkin eruptions and bacterial or viral infections. hyperlipemia. SGPT increased. tinea cruris. caution should be exercised when treating nursing mothers. dyspepsia. Some common side Effects include: headache. Dosage and Administration: Constipation: Initially Osmolax solution may be given twice daily. Ostel TM Active Ingredient: Sodium Alendronate. 155 Osmolax solution may. Preparation: 5 gm Dental Gel. be taken with water. which may enable the patient to reduce the dose gradually over a period of time. O Osmolax TM Active Ingredient: Lactulose. Paget’s disease of bone. in nursing babies. Contraindication and Precaution: Galactosaemia. Children: No dosage recommended for this indication. diarrhoea. Indication: Osteoporosis. Side Effect: Allergies.5 ml twice daily.2. A maintenance dose of 15 ml per day provides only 14 kilocalories and is therefore. Drug Interaction: Information regarding drug interaction is not known. Children under 1 year . encephalopathy.10 ml twice daily. clinical experience has shown that this medicament does exhibit a ‘carry-over’ Effect. use of this drug is acceptable. Use in Pregnancy : If laxative therapy is needed in pregnancy.4 gm/5 ml Solution. Children under 12 years of age should be supervised in the use of this product. 30 minute before breakfast. but the following serves as a guide line:Starting dose: Adults: (including the elderly) . . Because of Lactulose’s physiological mode of action it may take up to 48 hours before Effects are obtained. The product should not be used more than 7 days unless directed by a doctor/dentist. Dosage and Administration: 70 mg tablet once weekly or 10 mg tablet once daily. Subsequently adjust the dose to produce two or three soft stools each day. In due course the dose should be adjusted according to the needs of the individual. Hepatic encephalopathy: Adults (including the elderly): Initially 30-50 ml three times a day. Contraindication and Precaution: In patients who are hyper-sensitive to this medication or to any of its ingredients. use of the product should be discontinued. hepatic Preparation: 3. Pregnancy and Lactation: Benzocaine has not been reported to cause birth defects or other problems in pregnant women. However. lactose intolerance. Children under 5 years . Children: 5 to 10 years .15 ml twice daily. if necessary. gastro-intestinal obstruction. Side Effect: Meteorism and increased flatulence.5 ml twice daily.Product Guide as directed by a doctor/dentist. swelling in the mouth or throat etc. or to other ‘caine’ anesthetics. Indication: Constipation. unlikely to adversely affect diabetic patients. If condition persists or irritation develops. as well as. fruit juice etc. flatulence. Patients should not lie down for at least 30 minutes after taking Alendronate until after their first food of the day. Caution should be used when alendronate is given to patients with active upper gastrointestinal problems such as dysphagia. To facilitate delivery to the stomach and thus to reduce the potential for esophageal irritation.156 Side Effect: esophageal reactions. Other beverages (including mineral water). Incidence of upper gastro-intestinal adverse events associated with NSAID and aspirin appears to be greater with concomitant administration of alendronate. Alendronate can cause local irritation O Drug Interaction: Calcium supplement. such as stricture or achalasia • Inability to stand or sit upright for at least 30 minutes •Hypersensitivity to any component of this product •Hypocalcaemia Hypocalcaemia and other disturbances of mineral metabolism should be corrected before initiation of therapy. Contraindication and Precaution: esophageal stricture or achalasia. gastritis. beverage or medication of the day with plain water only. abdominal pain and distension. Contraindication & Precaution: •Abnormalities of the esophagus which delay esophageal emptying. Alendronate is not recommended for patients with more severe renal insufficiency (creatinine clearance <35 ml). Ostel -D Active Ingredient: Sodium Alendronate + Vitamin D3 (Colecalciferol) TM . duodenitis or ulcers. Ostel-D must be taken at least 30 minutes before the first food. rash. Treatment of Osteoporosis in Postmenopausal Women: For the treatment of osteoporosis Ostel-D increases bone mass and reduce the incidence of fractures. esophageal disease. To permit adequate absorption. Preparation: 10 mg and 70 mg Tablet. including those of the hip and spine. Product Guide Indication: 1. Treatment to increase bone mass in men with osteoporosis: Ostel-D 70/2800 tablet once weekly or Ostel-D 10/400 tablet once daily.musculoskeletal pain. food and some medications are likely to reduce the absorption of Alendronate. headache. hypocalcaemia and other disturbances of mineral metabolism. antacids and some oral medications will interfere with absorption of alendronate if taken at the same time. 2. erythema and transient decreases in serum calcium and phosphate. Use in Pregnancy and Lactation: Alendronate has not been studied in pregnant and breast feeding women and should not be given to them. hypersensitivity . Patients should not chew or suck on the tablet Ostel-D should not be taken at bed time. diarrhoea or constipation. Intravenous ranitidine makes the bioavailability of oral alendronate double. Treatment to Increase Bone Mass in Men with Osteoporosis Dosage & Administration: Treatment of osteoporosis in post-menopausal women: Ostel-D 70/2800 tablet once weekly or Ostel-D 10/400 tablet once daily. Ostel-D tablet should only be swallowed upon rising for the day with a full glass of water. duodenitis or ulcers. A combination of symptoms. If a patient enters a manic phase. O Oxat 20 TM Active Ingredient: Paroxetine. Preparation: 5 mg & 10 mg Tablet. Use in Pregnancy & Lactation: Alendronate Sodium is pregnancy category C. myoclonus and hyperthermia. Side Effect: Usually mild and generally do not require discontinuation of therapy. Dosage and Administration: Adults : 1 tablet once daily. diarrhea.musculoskeletal pain. erythema and transient decreases in serum calcium and phosphate. Side Effect: Agitation or restlessness. No dosage adjustment is necessary for the elderly or for patients with mild-tomoderate renal insufficiency (creatinine clearance 35 to 60 ml/min). headache. Obsessive Compulsive Disorder. Preparation: 10/400 Tablet & 70/2800 Tablet. Side Effects include esophageal reactions. It is not known whether alendronate is excreted in human milk. rash. Ostel-D is not recommended for patients with more severe renal insufficiency (creatinine clearance < 35 ml/min). increased or decreased appetite. Social Anxiety Disorder. Overdoses of vitamin-D have shown teratogenic Effects in pregnant animals. blurred vision. Contraindication and Precaution: Known hypersensitivity. 157 maintenance therapy to prevent people with depression from suffering a relapse. sexual difficulties (decreased sexual ability or desire. Colecalciferol and some of its active metabolites pass into breast milk. nausea.flatulence. confusion. Patients should stop taking medicine and consult their physician if they develop esophageal diseases. Indication: Major Depressive Disorder. Indication: Major depressive disorder and . tremor (shaking). Escitalopram Oxalate should be discontinued. may indicate the development of this condition. Dosage and Administration: 20 mg as a single daily dose. indigestion. abdominal pain and distension. ejaculatory delay). Caution should be exercised when Ostel-D is administered to lactating women. Escitalopram should be used cautiously in patients with a history of mania. gastritis. tremor. weight changes. Generalized Anxiety Disorder. Caution should be used when Alendronate is given to patients with active upper gastrointestinal problems such as dysphagia. esophageal disease. Use in Pregnancy and Lactation: Not recommended. Ostel-D should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus. diarrhoea or constipation. increased sweating.Product Guide of the upper gastro-intestinal mucosa. Oxapro® Active Ingredient: Escitalopram. taste alterations. Posttraumatic Stress Disorder. possibly including agitation. As with all drugs effective in the treatment of major depressive disorder. Panic Disorder. and tinea corporis due to Trichophyton rubrum. tremor. Drug Interaction: Potential drug interactions between Oxiconazole and other drugs have not been systematically evaluated.158 Contraindication: MAOIs or thioridazine. somnolence. insomnia. and papules. stinging and nodules. Side Effect : Pruritus. ejaculatory disturbance and other male genital disorders. Preparation: 20 mg Tablet. Contraindication and Precaution: Recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine.. Indication: Indicated for the topical treatment of the following dermal infections: tinea pedis. Trichophyton mentagrophytes. Use in Pregnancy and Lactation: The drug should be used during pregnancy and lactation if potential benefit justifies the potential risk to the fetus. Product Guide daily in the treatment of tinea (pityriasis) versicolor. venous leg ulcers. and theobromine. recent surgery. rash. hematocrit and/or hemoglobin.g. Oxifun® Cream should be applied once . and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence. Dosage & Administration: One tablet two to three times a day with meals for at least 8 weeks. Preparation: 1% Cream. Side Effect: Asthenia. maceration. dizziness. Warfarin. Drug Interaction: Tryptophan. nausea. theophylline. female genital disorders. impotence. ® Oxifun® Active Ingredient: Oxiconazole. hypersensitivity. fissure. cerebral and/ or retinal bleeding) should have periodic examinations for bleeding including. erythema. tinea corporis. or tineacruris. Oxifun® Cream is indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur. Indication: Treatment of peripheral vascular disease evident as intermittent claudication. folliculitis. irritation and allergic contact dermatitis. somnolence. nervousness. Patients should be cautioned about their ability to drive a car and operate machinery. decreased appetite. nausea. Tinea corporis. peptic ulceration. Alcohol. constipation. Patients on warfarin should have frequent monitoring of prothrombin times. burning. tinea cruris. epilepsy. or Epidermophyton floccosum. while patients with other risk factors complicated by hemorrhage (e. dizziness. O Oxifyl CR Active Ingredient: Pentoxifylline. sweating. tinea cruris. dry mouth. Dosage & Administration: Oxifun® Cream should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis. Precaution: Cardiac conditions. rhinitis or urticaria during therapy with aspirin or other non-steroidal antiinflammatory drugs. Concomitant use of cyclosporin. earache. flatulence. angioedema. dysuria. dyspepsia. Etodolac should be used with caution in patients with fluid retention. dizziness. scotoma. ulcerative stomatitis. hepatic function abnormalities and jaundice. a decision should be made whether to discontinue nursing or discontinue the drug. Use in Pregnancy and Lactation: Safety in human pregnancy has not been established and Etodolac should not be used during pregnancy. rash. excessive salivation. Side Effect: Reported side Effects include nausea. Etodolac should not be used in patients with active peptic ulceration or a history of peptic ulcer disease. Contraindication & Precaution: Etodolac should not be used in patients who have . pruritus. bad taste. Preparation: 600 mg SR Tablet. nasal congestion. it may be necessary to modify the dosage of other highly protein-bound drugs. weakness/malaise. Indication: Etodolac is indicated for acute or long-term use in rheumatoid arthritis and osteoarthritis. constipation. anxiety. urticaria. dyspnoea. Elderly: No change in initial dosage is generally required in the elderly.Product Guide Side Effect: Dyspnea. tremor. blurred vision. confusion. tinnitus. diarrhoea. rash. paraesthesia. abnormal vision. conjunctivitis. P Panodin® SR Active Ingredient: Etodolac. oedema. The safety of doses in excess of 600 mg per day has not been established. Because of the potential for tumorigenicity shown for pentoxifylline in rats. or lithium with NSAIDs may cause an increase in serum levels of these compounds and associated toxicities. Drug Interaction: Since Etodolac is extensively protein-bound. bilirubinuria. Dosage & Administration: Adults: One tablet daily. dry mouth/thirst. fatigue. flu-like symptoms. Preparation: 400 mg CR (Controlled Release) Tablet. laryngitis. taking into account the importance of the drug to the mother. epistaxis. Safety of Etodolac use during lactation has not been established and as such its use in nursing mothers should be avoided. anorexia. methotrexate. anaphylactoid reaction. cholecystitis. sore throat/ swollen neck glands. pruritus. Use in Pregnancy and Lactation: Used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Warfarin. melaena. insomnia. Children: Not recommended. epigastric pain. gastritis. heartburn. Due to possible cross-reactivity. leukopenia. depression. angioedema. vasculitis. brittle fingernails. Drug Interactions: Theophylline. hypertension or heart failure. digoxin. hypotension. weight change. haematemesis. confusion. pyrexia. constipation. seizures. edema. drowsiness. malaise. headaches. urticaria and Stevens-Johnson syndrome. indigestion. palpitations. abdominal pain. depression. colitis. Etodolac should not be administered to patients who experience asthma. rectal bleeding. urinary frequency. 159 previously shown hypersensitivity to it. vomiting. photosensitivity. pain lasts for more than 10 days. Methyl salicylate (Oil of Wintergreen) 30% & Menthol 8% Cream. the safety and Effectiveness of Tapentadol has not been established. Do not use with a heating pad. myxedema. do not use and call a physician. P Pentadol TM Active Ingredient: Tapentadol. hypercapnia or respiratory problems such as: asthma.160 Product Guide 100 mg every 4 to 6 hours and should be adjusted to maintain adequate analgesia with acceptable tolerability. minor arthritis. Indication: Pentadol tablet is indicated for the relief of moderate to severe acute pain in patients 18 years of age or older. Preparation: Methyl salicylate (Oil of Wintergreen) 15% & Menthol 10% Cream. On the first day of dosing. therefore. Dosage & Administration: The dose is 50 mg. the second dose may be administered as soon as one hour after the first dose. Dosage & Administration: It is applied to affected areas not more than 3 to 4 times daily. mucous membranes. Tapentadol has not been studied in patients with severe hepatic impairment. chronic obstructive pulmonary disease etc. if adequate pain relief is not attained with the first dose. Use in renal disease In patients with severe renal impairment. backache. It is also contraindicated in patients with acute or severe bronchial asthma or hypercapnia in unmonitored settings or the absence of resuscitative equipment. use of Tapentadol is not recommended in this population Contraindication & Precaution: This drug is contraindicated in patients with impaired Pulmonary Function. This drug is contraindicated in any patient who has or is suspected of having paralytic ileus. broken or irritated skin. Do not bandage tightly. Indication: Joint pain & inflammation. Daily doses greater than 700 mg on the first day of therapy and 600 mg on subsequent days have not been studied and are not recommended. Warnings: For external use only. Do not swallow. or . 75 mg. or with arthritis-like conditions in children under 12. Alternative non-mu-opioid agonist analgesics should be considered and Tapentadol should be employed only under careful medical supervision at the lowest Effective dose in such patients. Keep away from eyes. or 100 mg every 4 to 6 hours depending upon pain intensity. Use in hepatic disease Tapentadol should be used with caution in patients with moderate hepatic impairment. kyphoscoliosis. 75 mg. Subsequent dosing is 50 mg. If skin redness or excessive irritation develops. muscle pain. In case of patient with sleep apnea syndrome. Penrif ® Active Ingredient: Methyl salicylate (Oil of Wintergreen) & Menthol. Tapentadol should be administered with caution to patients with conditions accompanied by hypoxia. central nervous system (CNS) depression should have to be cautious prior administration of Tapentadol. Restlessness and agitation in the elderly (oral). Indication: Streptococcal infections. drug withdrawal syndrome. There are no adequate and well-controlled studies in pregnant women. . Childhood schizophrenia. paresthesia. other tranquilizers. hypersensitivity. sedatives. edema. dysarthria. involuntary muscle contractions. Aspirin. blood pressure decreased etc. aminoglycosides. coordination abnormal. hypoesthesia.zinc and sulphaethidole. ataxia. especially paranoid (oral and IM). Gilles de la Tourette syndrome. Mania and hypomania (oral and IM). irritability. syncope. 500 mg DS Tablet. seizure. abdominal discomfort. Children (Oral administration only) : Childhood behavioral disorders especially when associated with hyperactivity and aggression. severe acute infections. visual disturbance.Product Guide Side Effect: The following treatmentemergent adverse events may happen: heart rate increased. Side Effect: Diarrhoea. urticaria. 161 Contraindication & Precaution: Known to be hypersensitive. Nausea and vomiting (IM). Magnesium carbonate. Drug Interaction: Patients receiving other mu-opioid agonist analgesics. Mental or behavioral problems such as aggression. mild erysipelas. 100 ml (125 mg/5 ml) Powder for Suspension. hypnotics. Penvik® Active Ingredient: Phenoxymethyl Penicillin. lobar pneumonia. Neonates whose mothers have been taking Tapentadol should be monitor for respiratory depression. memory impairment. serum sickness. Use in Pregnancy & Lactation: Pregnancy Category C. 100 ml (250 mg/5 ml) Forte Powder for Suspension. sulphamethoxypyrida. This combination preparation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. vomiting. Preparation: 250 mg Tablet. heart rate decreased. abdominal discomfort. Calamine etc. P Peridol ® Active Ingredient: Haloperidol. Indication: Adult: Schizophrenia: Other psychoses. presyncope. impaired gastric emptying. nausea. Preparation: 50 mg & 75 mg Tablet. spontaneous petechial hemorrhages. hyperactivity and selfmutilations in the mentally retarded and in patients with organic brain damage. Dosage & Administration: 250 to 500 mg 6 hourly. severe psychomotor agitation. Gilles de la Tourette syndrome and severe tics (oral). excitement. Magnesium oxide. sensation of heaviness. Use in Pregnancy and Lactation: There are no contraindications to the use of penicillin in pregnancy. bacterial endocarditis. general anesthetics. disturbance in attention. sedation. Intractable hiccup (oral). phenothiazines. or other CNS depressants (including alcohol) concomitantly with Tapentadol may exhibit additive CNS depression. Drug Interaction: Zinc oxide. scarlet fever. violent or dangerously impulsive behavior (oral and IM). tremor. insomnia. vertigo.0 mg bd or tds. Mydriasis. Use in Pregnancy and Lactation: There is no proven harmful Effect in the first trimester.25 mg once daily. if necessary.I. blurred vision. parkinsonian rigidity. an allergic reaction (rash) or muscular weakness.5 mg/day on a weekly basis up to a dose of 9 mg/ day. After 2 days. bradycardias or other arrhythmias. Contraindication & Precaution: Caution in children and geriatric patients. Perkirol TM Active Ingredient: Ropinirole. lesions of the basal ganglia. It is advisable to be cautious in giving Perkinil to patients with diarrhea and . effects (nausea. blurred vision and adverse G. daily dosage may be increased by 1. confusional states or epileptic fits. Indication: Parkinson’s Disease. hepatic or renal impairment.5 mg 3 times a day. sedation. the dosage can be increased to 0. Indication: Parkinson’s disease. Restless Legs Syndrome: Starting dosage is 0. urinary retention. drowsiness. Product Guide cardiovascular disease. constipation). As with other dopaminergic drugs. vomiting. Parkinson’s disease. caution should be exercised when these compounds are given concomitantly with Ropinirole because of the unknown potential for the occurrence of hypotension. 1 to 3 hours before bedtime. Side Effect: Dryness of the mouth . constipation and dyspepsia. and then by up to 3 mg/day weekly to a total dose of 24 mg/day. then 5 mg 3 times a day and occasionally 5 mg at night. Perkinil ® Active Ingredient: Procyclidine. patients with severe cardiovascular disease should be treated with caution. dry mouth. urinary retention.5 mg once daily and to 1 mg once daily at the end of the first week of dosing. epigastric distress. Preparation: 5 mg Tablet and 10 mg/2 ml Injection. glaucoma. Patients should be informed and advised to exercise caution while driving or operating machines P Drug Interaction: Haloperidol with lithium may predispose to the neuroleptic malignant syndrome. confusion and hallucination. depression. Dosage and Administration: Parkinson’s Disease: Starting dose is 0. oculogyric crises and laryngeal dystonia. Restless Legs Syndrome. Contraindication and Precaution: Hypersensitivity to Ropinirole. vertigo and apparent exacerbation of psychotic symptoms. known hypersensitivity to haloperidol.25 mg 3 times daily. Dosage and Administration: 2. acute dystonia. Contraindication & Precaution: CNS depression. Co-administration of antidopaminergic antiemetics increases the risk of extrapyramidal adverse Effects. Preparation: 5 mg Tablet. loss of appetite. After week 4. agitation.162 Dosage and Administration: Initial dosage: Moderate symptomatology 1. Side Effect: Extrapyramidal symptoms.53. nausea. headache. Leave for 15 (fifteen) minutes before use. ciprofloxacin. fluvoxamine and cimetidine. abdominal pain. Preparation: 0. Dosage & Administration: Peuritar 1: For drinking water: 1 (one) tablet to 1 (one) liter of water. Preparation: 17 mg & 51 mg Tablet. Repeated or prolonged contact may cause dermatitis. bradycardia. Side Effect: Skin contact: There may be irritation and redness at the site of contact. Ingestion: There may be nausea and vomiting. It can also be used for washing fruits and vegetables and for cleaning teeth. Very toxic to aquatic organisms. Contraindication and Precaution: Tubercular or luetic skin infections or . If tablet is swallowed. Dosage and Administration: Apply by gently rubbing onto the skin twice daily for 14 days. Double the amount of tablets if the water is heavily contaminated. vegetables washing water: 3 (three) tablets to 1 (one) liter of water. It may react violently with many substances. Inhalation: Mild poisoning causes cough. excessive daytime somnolence and sudden sleep onset episodes. Side Effect: Nausea. syncope. P Peuritar® Active Ingredient: Sodium Dichloroisocyanurate.25 mg & 2 mg Tablet. 163 (three) tablets to 3 (three) liters of water. Leave for 15 (fifteen) minutes before use. Harmful if swallowed. For fruits. somnolence. vegetables washing water: 3 Pevitin® Active Ingredient: Econazole Nitrate and Triamcinolone Acetonide. Peuritar 3: For drinking water: 1 (one) tablet to 3 (three) liters of water. Indication: Effervescent water purification tablets make water safer by destroying harmful micro-organisms. redness and irritation. Contraindication & Precaution: Do not use with other products. may cause long term adverse Effects in the aquatic environment. causing fire and explosion hazard. Indication:Inflammatory dermatomycoses and inflammatory skin conditions which can be complicated by or threatened by bacterial or fungal skin infection. Double the amount of tablets if the water is heavily contaminated. occasionally with abdominal pain. For fruits. leg edema. Drug Interaction: Neuroleptics and other centrally acting dopamine antagonists. seek medical advice immediately. It may release dangerous gases (chlorine). decreases in systolic blood pressure. Use in Pregnancy and Lactation: Ropinirole should not be used during pregnancy and in nursing mothers. symptomatic hypotension.Product Guide during treatment with Ropinirole. oestrogens. irritation of the throat and shortness of breath. vomiting. such as sulpiride or metoclopramide. Eye contact: There may be severe pain. theophylline. osteomyelitis. hypersensitivity to imidazoles or corticosteroids. Preparation: 250 mg Capsule. Use in Pregnancy and Lactation: The use of Flucloxacillin in pregnancy should be reserved for cases considered essential by the clinician. Drug Interaction: No information is available. Adjunctive Therapy in Epilepsy: Topiramate is indicated as adjunctive therapy for adults and pediatric patients ages 2-16 years with partial onset seizures. Studies suggest that Topiramate is Effective against infantile spasms. Hypersensitivity. 125 mg/5 ml Powder for Suspension.164 in viral diseases (e. 500 mg Injection. empyema. vitamin mixtures. prophylactic agent during major surgical procedures for example. cardiothoracic and orthopaedic surgery. infected burns. nausea.g. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delay). otitis media and externa. furunculosis. Side Effect: Local mild irritation . endocarditis. and quinsy. Monotherapy in Epilepsy: Topiramate is indicated as initial monotherapy in patients of 10 years of age and older with partial onset or primary generalized tonicclonic seizures. septicaemia. urinary tract infections. Under 2 years : quarter of the adult dose. diarrhoea. It has been used by psychiatrists to treat bipolar disorder and alcoholism. 2-10 years : half of the adult dose. tonsillitis. impetigo. blood products and protein hydrolysates or other proteinaceous fluids.g. eczema and acne. protection for skin grafts. infected skin conditions. meningitis. infected wounds. telangiectasia and striae. 250 mg/5 ml Forte Powder for Suspension. skin rashes. ulcer. abscesses. varicella). Preparation: (10 mg + 1 mg)/gm cream. Phylopen TM Piramed® Active Ingredient: Topiramate. Indication: This drug is used to treat epilepsy in both children and adults. herpes. The drug is also used to treat Post Traumatic Stress Disorder. sinusitis. Product Guide streptomycin sulphate. Dosage & Administration: Adult : 500 mg six hourly. enteritis. lipids. adrenal suppression. and in patients 2 years of age and older with seizures associated with P Active Ingredient: Flucloxacillin Indication: Boils. pneumonia. Long term therapy with corticosteroids can cause skin lesions such as atrophy. cellulitis. Drug Interaction: Gentamicin sulphate. vaccinia. or primary generalized tonic-clonic seizures. e. carbuncles. lung abscess. Contraindication: Penicillin hypersensitivity. 500 mg DS Capsule. . pharyngitis. Side Effect: Uncommon. It is now most frequently prescribed for the prevention of migraines. Product Guide Lennox-Gastaut syndrome. Patients Undergoing Hemodialysis: Topiramate is cleared by hemodialysis at a rate that is 4 to 6 times greater than a normal individual. Side Effect: The most common side Effects include a change in taste and feelings of pins and needles in the head and extremities. or changes in mental status. Titration should begin at 25 mg (or less. Daily doses above 1600 mg have not been studied. Topiramate tablets can be taken without regards to meals. Adjunctive Therapy Use: Adults (17 Years of Age and Over) The recommended total daily dose of Topiramate is 400 mg/day in Partial Seizures or Primary Generalized TonicClonic Seizures. To avoid rapid drops in Topiramate plasma concentration during hemodialysis. one-half of the usual adult dose is recommended. Common doses for maintenance treatment are 100 to 200 mg daily. renal P . The actual adjustment should take into account 1) the duration of dialysis period. a prolonged period of dialysis may cause Topiramate concentration to fall below that required to maintain an anti-seizure Effect. Dose titration should be guided by clinical outcome. Less common side Effects include cognitive deficiency (particularly word-finding difficulty). The dosage should then be increased at 1 or 2 week intervals by increments of 1 to 3 mg/kg/ day (administered in two divided doses). The usual initial dose is 25 to 50 mg daily in 2 single doses. difficulty in understanding. 2) the clearance rate of the dialysis system being used. Accordingly. In patients who develop unexplained lethargy. Dosage & Administration: The initial dose normally is low and increased in slow steps. vomiting. Such patients will require a longer time to reach steady-state at each dose. Concomitant administration of Topiramate and valproic acid has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone. and 3) the Effective renal clearance of Topiramate in the patient being dialyzed.000 mg daily in divided doses.73 m2). grogginess. Pediatric Patients (Ages 2 to 16 Years) Partial Seizures or Primary Generalized Tonic-Clonic Seizures: The recommended total daily dose of Topiramate tablets as adjunctive therapy for patients with partial seizures or primary generalized tonic-clonic seizures is approximately 5 to 9 mg/kg/day in two divided doses. to achieve optimal clinical response. Recommended increments are 25 to 50 mg every 1 or 2 weeks. The highest dose possible is 1. Monotherapy Use: The recommended maximum dose for Topiramate monotherapy in adults and children 10 years of age and older is 400 mg/day in two divided doses. based on a range of 1 to 3 mg/kg/day) nightly for the first week. hyperammonemic encephalopathy should be considered and an ammonia level should be measured. 165 Patients with Renal Impairment: In renally impaired subjects (creatinine clearance less than 70 ml/min/1. a supplemental dose of Topiramate may be required. Migraine: Topiramate is indicated for adults for the prophylaxis of migraine headache. lethargy. Contraindication & Precaution: Topiramate tablets are contraindicated in patients with a history of hypersensitivity to any component of this product. So it may be given only if clearly needed and after the assessment of risk benefit ratio. or other allergic reactions. Dosage and Administration: A dose of 20 mg/day to 60 mg/day is recommended. breast pain. Active Ingredient: Prochlorperazine. Use in Pregnancy and Lactation: Should not be prescribed in pregnancy and lactation. intense sweating. vomiting and attacks of dizziness or spinning sensations (vertigo) associated with Meniere’s disease and other inner ear disorders. maximum: 7. Other Antidepressants: There have been greater than two fold increases of previously stable plasma levels of other antidepressants. Relieving nausea. Lithium: There have been reports of increased or decreased lithium levels when used concomitantly with fluoxetine. So caution should be taken if it is prescribed to a breast feeding mother. Hypersensitivity to Fluoxetine. nausea and diarrhea . maximum: 10 mg/day 19-39 kg: 5 mg every 12 hours as needed. Drug Interaction: MAO inhibitors: Serious sometimes fatal reactions have been reported with concomitant use. Side Effect: Anxiety. Indication: Depressive illness. Contraindication & Precaution: Monoamine Oxidase inhibitors. Preparation: 20 mg Capsule. maximum: 15 mg/day Adults: Oral: 5-10 mg 3-4 times/day. Usage in nursing mothers. tremor. Obsessive compulsive disorders. abdominal pain. and other conditions. Other side Effects include angioedema. and GI distress. for the treatment Psychotic illness such as schizophrenia (hallucinations and hostility). Product Guide Tryptophan: Patients experience adverse reactions including agitation. It is not known whether Topiramate is excreted through breast milk. gastrointestinal complaints. acute mania. and dizziness or light headedness. Severe renal failure. Preparation: 25 mg & 200 mg Tablet. including anorexia. Prolert TM Promtil TM P Active Ingredient: Fluoxetine. nervousness and insomnia. urticaria. Dosage & Administration: Children (not recommended in children <10 kg or <2 years): 10-14 kg: 2. for the short-term treatment of generalized non-psychotic anxiety.5 mg/day 15-18 kg: 2. weight loss. surgery. menstrual disorder and dry mouth. restlessness. Indication: For control of severe nausea and vomiting caused by radiation therapy.166 (kidney) stones. cancer chemotherapy. vision abnormality. Pregnancy & Lactation: Topiramate is pregnancy category C. drowsiness and fatigue or asthenia. Bulimia nervosa and anorexia nervosa. sweating. Pre-menstrual syndrome.5 mg every 12-24 hours as needed. usual maximum: 40 mg/day Contraindication & Precaution: .5 mg every 8-12 hours as needed. Use in Pregnancy & Lactation: No evidence of adverse Effects of this drug has been reported during pregnancy & lactation.Product Guide Hypersensitivity to prochlorperazine or any component of the formulation. Caution should be taken while performing tasks that require alertness. Indication: Proxivir is indicated for the treatment of: • Chronic hepatitis B virus infection in adults  • HIV infected adults in combination with other anti retroviral agents. shuffling walk.5 mg/ ml Injection. This medication can reduce sweating making more susceptible to heat stroke. Drug Interaction: Propranolol. 12. fine worm-like tongue movements. women who are or may become pregnant. slow or difficult speech. Dose adjustment in renal impairment: Tenofovir is eliminated by renal excretion. warfarin. severely diminished urinary flow. decreased libido. and decreased volume of ejaculate. nervous system problems. Side Effect: Impotence. Preparation: 5 mg Tablet. 167 Contraindication and Precaution: Hypersensitivity to any component of this product. neck. severe CNS depression. mouth. or jaw movements. P Proxivir® Active Ingredient: Each film coated tablet contains Tenofovir Disoproxil Fumarate INN 300 mg equivalent to 245 mg Tenofovir Disoproxil. Use in Pregnancy and Lactation: Pronor is contra-indicated in women who are or may become pregnant. tremors. Indication: Treatment and control of benign prostatic hyperplasia (BPH). rhythmic face. Preparation: 5 mg Tablet. Reye’s syndrome. digoxin. alcohol or drug dependencies. glibenclamide. such as driving or using machinery. coma. Dosage & Administration: The recommended dose of Tenofovir in chronic hepatitis B virus infection in adults 18 years of age and older with adequate renal function is 300 mg once daily with or without food. Dosage and administration: Pronor one 5 mg tablet daily with or without food. theophylline. skin rash. Very high or very low blood pressure. difficulty swallowing. so the exposure to Tenofovir increases in Pronor® Active Ingredient: Finasteride. . should not be used in children <2 years of age or <10 kg. yellowing of the skin or eyes. This medication may increase sensitivity to sunlight. restlessness and pacing. blood disorders. allergies (especially drug allergies). and back muscle spasms. Use of alcohol can cause extreme drowsiness. It is not known whether finasteride is excreted in human milk. children. and antipyrine. jaw. Prolonged sun exposure should be avoided and a sunscreen and protective clothing should be taken when anybody is exposed to the sun. liver or heart disease. Side-Effect: Drowsiness. diarrhea and flatulence. vomiting. Lactic Acidosis & Severe Hepatomegaly with Steatosis: Though the risk of occurrence of lactic acidosis is low for Tenofovir. Preparation: Each box contains 12 tablets in Alu-Alu blister pack. Use in Children: Safety and Effectiveness of Tenofovir in pediatric patients below the age of 18 years have not been established. ribavirin and tacrolimus did not result in significant drug interactions. Contraindication & Precaution: Tenofovir is contraindicated in patients with known hypersensitivity to Tenofovir or any component of the product. oral contraceptives. Exacerbation of hepatitis after discontinuation of treatment: Discontinuation of Tenofovir therapy may be associated with severe acute exacerbation of hepatitis. as detailed below - Dosing interval adjustment of Tenofovir in patients with renal impairment Creatinine Clearance (ml/ ≥50 min) 30 to 49 10 t0 29 Haemodialysis patients Recommended (300mg) Every 24 Every 48 Every Every 7 days or after dosing Interval hours hours 72 to 96 approximately 12 hours hours of dialysis Dose adjustment in hepatic impairment: No dose adjustment is required in patients with hepatic impairment. treatment should be suspended in any patient who develops lactic acidosis or hepatotoxicity. methadone. It should be used during pregnancy only if clearly needed. Dosing interval should be adjusted in all patients with creatinine clearance <50 ml/min. Use in Pregnancy & Lactation: Pregnancy category B. lamivudine. Drug Interaction: Co-administration of Tenofovir with anti-retroviral. It is not known whether it is excreted in human milk. Side Effect: The most common side Effects are nausea. P Purotrol TM . Co-administration with other drugs: Tenofovir should not be administered concurrently with Emtricitabine & Tenofovir combination or Adefovir Dipivoxil.168 Product Guide patients with renal dysfunction. Mothers should be instructed not to breast feed if they are taking Tenofovir. The Effects of co-administration of Tenofovir with other drugs that are renally eliminated or are known to affect renal function have not been evaluated. entecavir. vaginitis.11 years of age Purotrol Tablet: 1/2 tablet (2. duodenal and gastric ulcers. somnolence. Contraindication Hypersensitivity. Patients with severe renal impairment (< 10 ml/min creatinine clearance) should not be administered such medicine. dark stools.Product Guide Active Ingredient: Dihydrochloride. vaginal moniliasis. Therefore. & Precaution: Side Effect: Nausea. it should be used with caution during pregnancy and only if the benefits to the mother outweigh any risk to the fetus. dizziness. Pregnancy & Lactation: The safety of Levocetirizine in pregnancy has not been established.5 mg / 5 ml Syrup. Cetirizine or its parent compound Hydroxyzine. . dry mouth. Indication:Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative Gastroesophageal Reflux Disease (GERD). dry mouth. stomatitis. Treatment of daytime and nighttime heartburn and other symptoms associated with GERD. R Rabeca TM Active Ingredient: Rabeprazole Sodium.5 years of age Purotrol Syrup: 2. Preparation: (30 mg + 1 gm + 500 mg)/ Strip. Amoxicillin Capsule and Clarithromycin Tablet. skin reactions. Maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD. Preparation: 5 mg Tablet & 2. headache. Since Levocitirizine is excreted in breast milk. headache. oral moniliasis. it is not recommended for use by the nursing mothers. Pylotrip® Active Ingredient: Lansoprazole Capsule.5 ml ( 1/2 teaspoonful) daily Children below 6 months of age: Not recommended Side-Effect: Generally Levocetirizine is well tolerated.Long-term . But in rare cases. Indication: Eradication of H. Contraindication: Hypersensitivity to Levocetirizine. vomiting. Use in Pregnancy and Lactation: Use only if the potential benefit justifies the potential risk of the mother. glossitis.5 mg) daily Purotrol Syrup: 5 ml (1 teaspoonful) daily Children 6 months . Dosage & Administration: Adult & children above 12 years of age Purotrol Tablet: 1 tablet (5 mg) daily Purotrol Syrup: 10 ml (2 teaspoonfuls) daily Children 6 .tongue discoloration. confusion. myalgia. pylori in active chronic gastric. fatigue and asthenia are reported. diarrhoea. Levocetirizine 169 Indication: It is indicated in the treatment of seasonal allergic rhinitis (two years & above) perennial and chronic idiopathic urticaria (six months and above) along with other allergic complications. Dosage and Administration: One strip twice daily for 7-14 days or as per the physician’s advice. No data is available on administration of Rabeprazole to pregnant women. However this drug should be used during pregnancy. Caution should be exercised in patients with severe hepatic impairment. In normal subjects. Most patients with Duodenal Ulcer heal within four weeks. Some patients with Zollinger-Ellision syndrome have been treated continuously with Rabeprazole Sodium for up to one year. Drug Intaraction: Rabeprazole is metabolized by the Cytochrome P-450 (CYP-450) drug metabolizing enzyme system. Diazepam as a single intravenous dose. It is important that patients comply with the full 7-day regimen. Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence: Rabeprazole Sodium 20 mg Twice Daily for 7 Days Amoxicillin 1000 mg Twice Daily for 7 Days Clarithromycin 500 mg Twice Daily for 7 Days. A few patients may require additional therapy to achieve healing. A decision should be made whether to discontinue nursing or to discontinue the drug. an additional course of treatment may be considered. Healing of Duodenal Ulcers: The recommended adult oral dose is 20 mg once daily after the morning meal for a period up to four weeks. In combination with Amoxicillin and Clarithromycin to eradicate Helicobacter pylori. Doses should be adjusted to individual patient needs and Product Guide should continue for as long as clinically indicated. including Zollinger-Ellison Syndrome. Maintenance of Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD Maintenance): The recommended adult oral dose is 20 mg once daily. If symptoms do not resolve completely after 4 weeks.170 treatment of pathological hypersecretory conditions. For those patients who have not healed after 8 weeks of treatment. taking into account R . Dosage and Administration: Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD): 20 mg to be taken once daily for 4 to 8 weeks.There are no data on the excretion of Rabeprazole into the breast milk. such as Warfarin and Theophylline given as single oral dose. Contraindication: Rabeprazole Sodium is contraindicated in patient with known hypersensitivity to Rabeprazole or to any component in the product. Treatment of Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome: The dosage of Rabeprazole Sodium in patients with pathologic hypersecretory conditions varies with the individual patient. Treatment of Symptomatic Gastroesophageal Reflux Disease (GERD): The recommended adult oral dose is 20 mg once daily for 4 weeks. an additional 8 week course may be considered. co-administration of Rabeprazole 20 mg QD resulted in an approximately 30% decrease in the bioavailability of Ketoconazole and increase in the AUC and Cmax for digoxin of 90% and 29% respectively. only if clearly needed. All three medications should be taken twice daily with the morning and evening meals. Precaution: Administration of Rabeprazole Sodium to patients with mild to moderate liver impairment resulted in increased exposure and decreased elimination. Rabeprazole does not have clinically significant interactions with other drugs metabolized by the CYP-450 system. Doses up to 100 mg QD and 60 mg BID have been administered. and Phenytoin given as a single intravenous dose. Use in Pregnancy & Lactation: Rabeprazole is FDA Pregnancy Category B. The recommended adult oral starting dose is 60 mg once a day. Some patients may require divided doses. Larger dose is required when used as supplement of anesthesia than that required for analgesia. Intraoperative analgesia: by intravenous injection 0. administered subcutaneously. headache. Myocardial infarction: By slow intravenous injection 10-20 mg. Preparation: 20mg/2ml (IM/IV) injection. myocardial infarction and hypotension. intramuscularly or intravenously. moderate to severe pain associated with myocardial infarction ( MI). Contraindication & Precaution: Known hypersensitivity to Nalbuphine Hydrochloride. Indications: Moderate to severe pain. dizziness. and for obstetrical analgesia during labor and delivery.4% ointment should be inserted into the anal cavity with an applicator. sweating. Maintenance doses may be given at intervals of 4 to 6 hours or the dose must be determined by the physician. Preparation: 20 mg Tablet. Side Effect: Generally Nalbuphine is well tolerated. Indication: For relief of pain associated with chronic anal fissure.1-0. Moderate to severe pain: by intravenous or intramuscular injection 10 . repeated after 30 minutes if necessary. Dosage should be adjusted according to the severity of the pain. 171 intervals. Children from 18 months to 15 years old: usually 0.5 mg/ kg at 30 minutes R Rectocare® Active Ingredient: Nitroglycerin.3 mg/kg repeated once or twice as necessary. Caution should be exercised when Nalbuphine Hydrochloride is administered to a nursing woman.3-1 mg/kg over 10-15 minutes with maintenance doses of 0.2 mg/ kg body-weight. Obstetrical analgesia during labor & delivery: by intravenous injection 0.2 mg/kg. Use in Children: The safety and effectiveness of Rabeprazole in pediatric patients have not been established. Use in Pregnancy & Lactation: Nalbuphine is pregnancy category B. and other medications which the patient may be receiving. vertigo. for preoperative and postoperative analgesia. Radirif ® Active Ingredient: Nalbuphine. billiary tract surgery. The . nausea. vomiting.5 mg/ kg in single intravenous administration as required. Caution should be taken in the following conditions: impaired respiration. Preoperative anesthesia: by intravenous or intramuscular injection 0. However. Dosage & Administration: The usual recommended adult dose is 10 mg for a 70 kg individual. Dosage & Administration: Nitroglycerin 0. adjusted as required. this dose may be repeated every 3 to 6 hours as necessary.25-0. few side Effects like sedation. child up to 0.20 mg for 70 kg patient. respiratory depression. dyspnea and asthma may be seen. impaired renal or hepatic function. given preferably by intravenous or intramuscular injection.Product Guide the benefit of the drug to the mother. as a supplement to balanced anesthesia.25-0. physical status of the patient. dry mouth. Drug Interaction:Theophylline. Product Guide patients with impaired hepatic and renal function.4% ointment is contraindicated in patients with known hypersensitivity to Nitroglycerin or other ingredients of the formulation. Preparation: 0. angioedema. glaucoma. R Use in Pregnancy & Lactation: This ointment should not be used during pregnancy and lactation.1% Ointment. Contraindication & Precaution: Hypersensitivity. Use in Pregnancy and Lactation: Clarithromycin is not recommended. chronic bronchitis. Remus® Active Ingredient: Tacrolimus. pruritus. pneumonia.172 ointment must be inserted at least 1cm into the anus. anorexia. Indication: Pharyngitis. Prolonged or repeated use of clarithromycin may result in an overgrowth of non-susceptible bacteria or fungi. generalized erythroderma. Preparation: 500 mg Tablet. Netherton’s Syndroms. . Use in Pregnancy and Lactation: Caution should be taken during pregnancy and lactation. sinusitis.500 mg for 7-14 days. Contraindication & Precaution: Nitroglycerin 0. Pediatric Use: Not recommend below 18 years of age. Dosage & Administration: Adults : Remac 250 . Nitroglycerin 0. itraconazole. increased intracranial pressure. Children: 7. ketoconazole. duodenal ulcers for eradication of H.4% ointment.5 mg/kg twice daily. Carbamazepine. calcium channel blockers and cimetidine. allergic reaction. The dose is twice daily up to a maximum of 8 weeks. It should not be used if patient suffers from severe anemia.03% & 0. pylori. Remac TM Active Ingredient: Clarithromycin. Side Effect: Skin Burning. Contraindication and Precaution: Hypersensitivity. skin and soft tissue infection. Side-Effect: Headache and dizziness is a common side Effect experienced with Nitroglycerin 0. hypotension. fleoconazole. Preparation: Each pack contains a tube of 15 gm ointment and an applicator. Drug Interaction: Erythromycin.4% ointment should be used with caution in patients who have severe hepatic or renal disease. Indication: Moderate to severe atopic dermatitis. Dosage and Administration: Twice daily for one week after clearing of signs and symptoms of atopic dermatitis. anxiety.Terfenadine. anaphylactoid reaction. caution should be taken in administering this antibiotic to Renorma® Active Ingredient: Tibolone. Product Guide Indication: Treatment of symptoms resulting from the natural or surgical menopause in post menopausal women. Prevention of osteoporosis in women who have gone through the menopause and are at high risk of fractures, but cannot take other medicines used to prevent osteoporosis. Dosage & Administration: Treatment of symptoms resulting from the natural or surgical menopause. Prevention of post-menopausal bone mineral density loss: The recommended dose is 2.5 mg once daily. Improvement of symptoms generally occurs within a few weeks, but optimal results are obtained when therapy is continued for at least 3 months. Women experiencing a natural menopause should commence treatment with tibolone at least 12 months after their last natural bleed. In case of a surgical menopause, treatment with tibolone may commence immediately. Contraindication & Precaution: Contraindicated in - pregnancy and lactation; known, past or suspected breast cancer; known or suspected estrogen dependent malignant tumors (e.g. endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia; previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism); arterial thromboembolic disease (e.g. angina, myocardial infarction, stroke or TIA); acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal; porphyria Precautions should be taken in - uterine fibroids or endometriosis,thromboembolic disorders, estrogen dependent tumors, hypertension, liver disorders (e.g. liver adenoma), diabetes, asthma, epilepsy etc. 173 Side-Effect: Gastrointestinal disorders like abdominal pain, skin and subcutaneous tissue disorders like abnormal hair growth, acne, reproductive system and breast disorders like vaginal discharge, genital pruritus, vaginal candidiasis etc. Use in Pregnancy & Lactation: US FDA pregnancy category D. Tibolone is contraindicated in lactating women. Use in Children: Not recommended. Preparation: 2.5 mg Tablet. Repres® Plus Active Ingredient: Perindopril Erbumine. Indapamide + R Indication: Essential hypertension. Dosage & Administration: One tablet daily, preferably to be taken in the morning and before a meal. Contraindication & Precaution: Absolute : Known allergy to perindopril, indapamide, or sulfonamides, history of Quincke’s edema linked to previous ACE inhibitor therapy, severe renal failure, serious liver disorder, hypokalemia, pregnancy, lactation. Relative: Combination therapy with lithium, potassium salts, potassiumsparing diuretics, and certain medicines which can cause heart rhythm disorders. Disorders of electrolyte balance, diabetes, gout, hypotension or strict sodium-free diets, heart or renal failure, atherosclerosis, renal artery stenosis, elderly. Side Effect: Asthenia, dizziness, headache, mood swings and/or sleep disturbances, cramps, hypotension, allergic reactions, skin rashes, gastrointestinal disorders, dry 174 cough, dry mouth, risk of dehydration in the elderly and in patients suffering from heart failure; changes in blood test results may occur. Drug Interaction: Combinations with lithium, potassium-sparing diuretics, potassium (salt), antiarrhythmic drugs which cause torsade de pointes, anesthetic drugs, cytostatic or immunosuppressive agents. Use in Pregnancy and Lactation: It should not be used during pregnancy. This drug should not be given to lactating women, as the possible Effect on the newborn is unknown. Preparation: (Indapamide 0.625 mg and Perindopril Erbumine 2 mg)/Tablet, (Indapamide 1.25 mg and Perindopril Erbumine 4 mg)/Tablet. Product Guide nausea, vomiting, constipation, diarrhea and postural hypotension. Electrolyte imbalances include hypochloremic alkalosis, hyponatremia, hypokalemia, hyperuricemia; hypersensitivity reactions which include skin rashes, cholestatic jaundice and blood dyscrasias including thrombocytopenia, leucopenia, aplastic anemia. Drug Interaction: Other Antihypertensive, Norepinephrine. Use in Pregnancy and Lactation: In pregnant women indapamide is not recommended. Mothers taking indapamide should not breast feed. Preparation: 1.5 mg SR (Sustained Release) Tablet. R Repres® SR Active Ingredient: Indapamide. Indication: Essential hypertension, hypertension in patients with renal function impairment, salt and fluid retention associated with congestive heart failure. Dosage & Administration: One tablet daily, preferably in the morning. Contraindication & Precaution: Known allergy to this drug or to sulphonamides, Renal failure, Serious liver disease, Hypokalemia, Disturbed water/electrolyte balance, diabetes, gout and kidney problems. Monitoring of potassium and uric acid serum levels is recommended. Side Effect: Dizziness, headache, anorexia, Revira® Active Ingredient: Valaciclovir. Indication: Revira is indicated for cold sore of adult & children, genital herpes, chicken pox & h erpes zoster. Dosage & Administration: Revira tablets may be given without regard to meals. Herpes Zoster: The recommended dosage for the treatment of herpes zoster is 1 gram orally 3 times daily for 7 days. Therapy should be initiated at the earliest sign or symptom of herpes zoster and is most Effective when started within 48 hours of the onset of zoster rash. Genital Herpes: Initial Episodes: The recommended dosage for treatment of initial genital herpes is 1 gram twice daily for 10 days. Recurrent Episodes: The recommended dosage for the treatment of recurrent genital herpes is 500 mg twice daily for 3 days. Suppressive Therapy: Product Guide The recommended dosage for chronic suppressive therapy of recurrent genital herpes is 1 gram once daily in patients with normal immune function. In patients with a history of 9 or fewer recurrences per year, an alternative dose is 500 mg once daily. In HIV-infected patients with CD4 cell count 100 cells/mm3, the recommended dosage for chronic suppressive therapy of recurrent genital herpes is 500 mg twice daily. Reduction of Transmission: The recommended dosage for reduction of transmission of genital herpes in patients with a history of 9 or fewer recurrences per year is 500 mg once daily for the source partner. Cold Sores (Herpes Labialis): The recommended dosage for the treatment of cold sores is 2 grams twice daily for 1 day taken about 12 hours apart. Patients with Acute or Chronic Renal Impairment: In patients with reduced renal function, reduction in dosage is recommended. Contraindication & Precaution: Valaciclovir is contraindicated in patients with a known hypersensitivity or intolerance to Valaciclovir, Aciclovir, or any component of the formulation. Side-Effect: Nausea, headache, vomiting, dizziness and abdominal pain may occur. In rare cases following adverse reactions reported: General: Facial edema, hypertension, tachycardia. Allergic: Acute hypersensitivity reactions including anaphylaxis, angioedema, dyspnea, pruritus, rash, and urticaria. CNS Symptoms: Aggressive behavior; agitation; ataxia; coma; confusion; decreased consciousness; dysarthria; encephalopathy; mania; and psychosis, including auditory and visual hallucinations; seizures, tremors. Eye: Visual abnormalities. 175 Gastrointestinal: Diarrhea. Hepatobiliary Tract and Pancreas: Liver enzyme abnormalities, hepatitis. Renal: Elevated creatinine, renal failure. Hematologic: Thrombocytopenia, aplastic anemia, leukocytoclastic vasculitis, TTP/ HUS. Use in Pregnancy & Lactation: Pregnancy Category B. Valaciclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Valaciclovir should be administered to a nursing mother with caution and only when indicated. Use in Children: Safety and effectiveness of Valaciclovir in pre-pubertal pediatric patients have not been established. Preparation: 500 mg & 1 gm Tablet. R Rex® Active Ingredient: Beta Carotene ,Vitamin C , and Vitamin E. Indication: Reduces risks of cardiovascular diseases in human, reduces risks of cataract, combat infection and chronic diseases, trend toward decreased agerelated degenerative changes, defense against infection. Dosage & Administration: 1 tablet daily. Contraindication & Precaution: Hypersensitivity , hyperoxaluria. Side Effect: Loose stools, yellow discoloration of skin, chronic overdosage can lead to peeling and redness of the skin, loss of appetite, diarrhoea and other gastro-intestinal disturbances. It has also 176 been stated abdominal pain, fatigue and weakness. Drug Interaction: Neomycin, bleomycin, aminophylline, nitrofurantoin sodium, conjugated oestrogens, sulphafurazole diethanolamine, chloramphenicol sodium succinate, chlorothiazide sodium and hydrocortisone sodium succinate. Use in Pregnancy and Lactation: High doses should not be given in pregnancy and lactation. Preparation: (6 mg + 200 mg + 50 mg)/ Tablet. Product Guide mg tablet strengths based on the dose of Pioglitazone and Metformin already being taken. The maximum recommended dose for Pioglitazone is 45 mg daily. The maximum recommended daily dose for Metformin is 2550 mg in adults. Contraindication: Renal disease or renal dysfunction which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia, Known hypersensitivity to Pioglitazone, Metformin or any other component of combination of Pioglitazone and Metformin, Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Use in Pregnancy & Lactation: Pregnancy category C. Should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Combination of Pioglitazone and Metformin should not be administered to a breastfeeding woman. Drug Interaction: Metformin hydrochloride: Furosemide, Nifedipine, Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin). Preparation: (Pioglitazone 15 mg and Metformin Hydrochloride 500 mg)/Tablet, (Pioglitazone 15 mg and Metformin Hydrochloride 850 mg)/Tablet. R Rezulin TM Active Ingredient: Pioglitazone and Metformin. Indication: Type 2 diabetes. Dosage and Administration: Starting dose for patients inadequately controlled on Metformin monotherapy based on the usual starting dose of Pioglitazone (1530 mg daily), Rezulin® may be initiated at either the 15 mg/500 mg or 15 mg/850 mg tablet strength once or twice daily, and gradually titrated after assessing adequacy of therapeutic response. Based on the usual starting doses of Metformin (500 mg twice daily or 850 mg daily), Rezulin® may be initiated at either the 15 mg/500 mg twice daily or 15 mg/850 mg tablet strength once daily, and gradually titrated after assessing adequacy of therapeutic response. Starting dose for patients switching from combination therapy of Pioglitazone plus Metformin as separate tablets Rezulin® may be initiated with either the 15 mg/500 mg or 15 mg/850 Rice ORS ® Active Ingredient: Rice ORS for 500 ml Product Guide Water: Each sachet contains Sodium Chloride BP 1.30 gm, Potassium Chloride BP 0.75 gm, Tri-Sodium Citrate Dihydrate BP 1.45 gm & Processed Rice Powder Pharma Grade 25 gm. Rice ORS for 250 ml Water: Each sachet contains Sodium chloride BP 0.650 gm, Potassium chloride BP 0.375 gm, TriSodium Citrate Dihydrate BP 0.725 gm & Processed Rice Powder Pharma Grade 12.500 gm Indication: Rice ORS is indicated in • Acute fluid and electrolyte loss conditions such as cholera, acute diarrhea & vomiting • Dehydration • Severely low concentrations of salts in the blood (severe electrolyte depletion) Dosage & Administration: Dose of Rice ORS depends on the severity of the dehydrating conditions of the patients. The following is a guideline: Age Recommended Dose after each watery stool •Severe diarrhea in infants 177 Precautions should be taken in case of significant overdose, especially for the following patients •Children less than 1 year of age •Patients with imbalance of salt concentrations in the blood (electrolyte imbalance) •Patients with severely decreased kidney function •Patients with severely decreased liver function Drug Interaction: There is no known drug interaction reported. Use in Pregnancy & Lactation: Rice ORS® is recommended in pregnancy & lactation, as there is no known harmful Effect when this medicine is used. Use in Children: Safety and effectiveness of Rice ORS in pediatric patients below the age of 6 months have not been established. Preparation: Rice ORS for 250 ml Water: Each box contains 10 sachets. Rice ORS for 500 ml Water: Each box contains 10 sachets. R 6 months to 2 50 ml to 100 ml (10 to years 20 Teaspoonfuls) 2 years to 9 100 ml to 200 ml (20 years to 40 teaspoonfuls) 10 years and 250 ml to 500 ml (1 to above 2 glassfuls) Contraindication & Precaution: Not to be used in •Kidney failure resulting in diminished production of urine •Kidney failure, preventing production of urine •Obstruction of the stomach or intestines •Reduced blood flow to vital internal organs (shock) •Severe and continuous vomiting (intractable vomiting) •Severe dehydration Ripril TM Active Ingredient: Ramipril. Indication: Mild to severe hypertension. Dosage and Administration: Initial dose is 1.25-2.5 mg once daily. Maintenance dosage in adult is 2.5-20 mg daily as single or in 2 divided doses. Contraindication: angioedema. Hypersensitivity, 5 or two tablets of Ripril® plus 5/25).Severe impairment of renal function. osteoporosis in men and women that is caused by treatment with steroid medicines such as prednisone. Indication: Osteoporosis in postmenopausal women. Maximum daily dose: 10 mg ramipril and 50 mg hydrochlorothiazide (four tablets of Ripril® plus 2. reduced blood volume (hypovolumia) or salt depletion should be corrected before initiating the treatment . and in patients with low blood pressure. pulmonary edema.fever.5 mg + Hydrochlorothiazide 12. dizziness. rash. Risedon 150 TM Active Ingredient: Risedronate Sodium 150 mg INN tablet. Dosage & Administration: One tablet orally. diarrhoea. cough. cough. anaphylactic reactions and hyperkalemia. vomiting. patients receiving ramipril and hydrochlorothiazide from separate tablets may instead wish to receive tablets of combination of Ripril plus 2. Product Guide Contraindication & Precaution: This product must not be used in patients with hypersensitivity to ramipril. To permit . headache.5 or Ripril® plus 5/25 tablet. vertigo etc. Ripril Plus Active Ingredient: Hydrochlorothiazide. hyperglycaemia.gastric irritation. Haemodynamically relevant unilateral or bilateral renal artery stenosis.178 Side Effect: Dizziness. hydrochlorothiazide or other thiazide diuretics. hypotension. mitral stenosis. Dosage and Administration: Dose Titration Guided by Clinical Effect A patient whose blood pressure is not adequately controlled with ramipril (or another ACE inhibitor) alone or with hydrochlorothiazide (or another thiazide diuretic) alone may be switched to combination therapy with Ripril® plus 2. hyperuricaemia. oliguria. Use in Pregnancy & Lactation: Not recommended. taken once a month. Paget’s disease of bone in men and women. electrolyte imbalance. hypotension. Replacement Therapy: For convenience. aortic stenosis. amnesia. Preparation: (Ramipril 2.5/12.5 mg) & Ramipril 5 mg + Hydrochlorothiazide 25 mg Tablet.5 mg & 5 mg Tablet.5/12. photosensitivity. fatigue and asthenia. angioneurotic edema. anxiety. Use in Pregnancy & Lactation: Not recommended. the dose may be increased to two tablets of Ripril® plus 2. Ramipril + ® R Indication: Mild to moderate hypertension in patients (in whom combination therapy is appropriate) who have been stabilised on the individual components given in the same proportion. urticaria.5 or Ripril® plus 5/25 once daily.diarrhoea. asthenia.5/12. Side Effect: Headache. Generally dehydration. nausea. nausea.If necessary.25 mg. osteoporosis in men. Preparation: 1.5 or Ripril® plus 5/25. 2. weakness. History of hereditary angioneurotic oedema.5/12. vomiting. low calcium and other mineral disturbances. headache.5 gm once or 500 mg twice a day for 5 days. Children: 40 mg/kg body weight once a day for 3 days. Ornidazole should be prescribed with caution. vertigo. jawbone problems in some people. In patient with ataxia. vomiting. It should not be given to nursing women.5 gm once daily for 1-2 days. Bacterial vaginosis. Ornidazole does not interact with alcohol. joints or muscles. Side Effect: Usually mild and generally do not require discontinuation of therapy. Unlike other nitroimidazoles. Sexual partner should also be treated at the same time. Use in Children: Safety and Effectiveness 179 in pediatric patients have not been established. Use in Pregnancy & Lactation: Pregnancy Category C. Robic® Active Ingredient: Ornidazole. Drug Interaction: Calcium supplement. Children: 10-25 mg/kg body weight in 2 divided doses. epigastric pain.Product Guide adequate absorption. It is only intended for use in postmenopausal women. antacids and some oral medications will interfere with absorption of Risedronate if taken at the same time. It should be taken according to the dosing instructions to minimize the risk of these events. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished R . or trouble swallowing. Side Effect: Nausea. sometimes severe. dizziness. Trichomoniasis : 1. Contraindication and Precaution: Hypersensitivity. Giardiasis: Adults : 1. pain in bones. Drug Interaction: Disulfiram-like reactions. and mental confusion. Treatment of susceptible anaerobic infections. tablet must be taken at least 30 minutes before the first food. Incidence of upper gastro-intestinal adverse events associated with NSAID and aspirin appears to be greater with concomitant administration of Alendronate. Dosage and administration: Amoebiasis : Adults: 500 mg twice a day for 5 days. peripheral neuropathy. Preparation: Risedon 150 Tablet: Each box containing 1X1 tablet in alu alu blister pack. which may include infection and slower healing after teeth are pulled & short-lasting. pain. and esophageal or gastric ulcers. Bacterial vaginosis : 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days. including ulcers. esophagitis. Side Effects include esophagus or stomach problems. Leukopenia has been described occasionally. epilepsy. Indication: Amoebiasis (Intestinal and hepatic). lassitude. Intravenous ranitidine makes the bioavailability of oral Risedronate double. beverage or medication of the day with plain water only. Children: 40 mg/kg body weight for 2 days. mild flu-like symptoms.5 gm once a day for 3 days. Trichomoniasis. Patients should discontinue use if new or worsening symptoms occur. and usually get better after the first dose. It is not known whether Risedronate is excreted in human milk. Amoebic dysentery : Adults : 1. Contraindication & Precaution: Risedronate may cause upper gastrointestinal disorders such as dysphagia. Giardiasis. Nongonococcal urethritis and cervicitis. asthenia. active liver disease or with unexplained persistent elevations of serum transaminases. Side Effect: Nausea. and nausea. abdominal pain. Drug Interaction: Antacids containing magnesium. Enteric fever. Multi-drug-resistant Tuberculosis. aluminium or calcium may decrease absorption of ofloxacin. uncomplicated skin and skin structure infections. vomiting. Myalgia. Preparation: 5mg. constipation.180 hepatic metabolism. Indication: Hypercholesterolemia. Urinary Tract Infections. dizziness and insomnia. Use in Pregnancy and Lactation: Not recommended. Indication: Chronic bronchitis lung abscess. Contraindication & Precaution: Hypersensitivity. Dosage and Administration: Two Saga tablets on first day as loading dose. Should be administered to women of childbearing age only when such patients are highly unlikely to conceive. Rosuva TM Active Ingredient: Rosuvastatin. thereafter one tablet of Saga every 24 hours for a total of 10 days therapy. Iron or Zinc may decrease oral absorption of ofloxacin. acute. Use in Pregnancy and Lactation: Ornidazole should be prescribed only if the potential benefit justifies the potential risk to foetus/neonate. Product Guide Active Ingredient: Ofloxacin. children or growing adolescents and in pregnant or breast feeding women. Contraindication: Hypersensitivity to Rosuvastatin on any of its components. gonorrhoea. Indication: Community acquired pneumonia. 10 mg & 20 mg Tablet. Chronic Bronchitis. Preparation: 200 mg Tablet. rash. abdominal pain. Ornidazole has been reported to decrease the clearance of 5-fluorouracil. Acute or chronic prostatitis: 200 mg twice daily for 28 days. For children 15 mg/kg/day in two divided doses. shigellosis. epilepsy. Side Effect: Generally well tolerated. Rutix® . Preparation: 500 mg Tablet. diarrhoea. Dosage & Administration: 200 mg to 800 mg daily from 5-7 days. S Dosage and Administration: 5-40 mg once daily. Saga® Active Ingredient: Sparfloxacin. pneumonia. drowsiness. Adjustment of the dosage regimen is necessary for the patients with impaired renal function creatinine clearance (< 50 ml/min). renal or liver damage. Contraindication and Precaution: Hypersensitivity. severe cardiac insufficiency. Drug Interaction: Antacids and Sucralfate. dryness of mouth. Sanit® Active Ingredient: Nortriptyline and Fluphenazine. dyspepsia. Dosage and Administration: One tablet three times daily. diarrhoea. subjective palpitations and headaches are usually mild and transient.Two puffs (50µg) twice daily. insomnia. non-specific chest pain. blood dyscrasias. Contraindication and Precaution: Epilepsy or brain damage. nasal congestion. Preparation: 200 mg Tablet. abdominal pain and QTc interval prolongation. Side Effect: Photosensitivity reaction. . Safety and Effectiveness have not been established in patients below the age of 18 years. Use in Pregnancy and Lactation & Children: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. faintness and constipation. Drug Interaction: Barbiturates. headache. S Salmate® HFA Inhaler Active Ingredient: Salmeterol. alcohol and narcotic drugs. Preparation: (10 mg + 0. hypokalamia. Side Effect: Tardive dyskinesias. Skin reactions. 200 puffs. tension and/or agitation with or without co-existing depression. blurred vision and excitement are seen. Indication: Mild to moderate anxiety.Product Guide Contraindication and Precaution: Hypersensitivity or photosensitivity reactions. 181 Drug Interaction:As with all the other beta2agonists there may be interaction with betablocking agents at the receptor site when given concomitantly. Monoamino Oxidase Inhibitors and Tricyclic Antidepressants : These agent should be used with caution because Salmeterol may be potentiated by these agents. Preparation: Inhaler : Salmeterol 25 mcg/ puff. dizziness. Indication: Asthma and Chronic Obstructive Pulmonary Diseases including chronic bronchitis and emphysema. local irritation and arthralgia have been reported. muscle cramps. nausea. Scabex® Active Ingredient: Permethrin.5 mg)/Tablet. Side Effect: Dose related tremor. Zinc/iron salts. Occasionally tachycardia. Dosage and Administration: For inhalation only . The majority of patients are healed after 4 weeks. duodenal ulcer and reflux esophagitis. Use in Pregnancy and Lactation: Permethrin is suggested not to use during pregnancy & lactation. Contraindication and Precaution: Hypersensitivity. rash and pruritus. eczema. acid reflux disease. It should be applied to the whole body excluding head. Indication: Seclo capsule and tablet is indicated for gastroesophageal reflux disease including reflux esophagitis. Side Effect: Skin discomfort. Children: 1/4 (15 gm) to 1/8 (30 gm) of a tube. Zollinger-Ellison Syndrome and for the treatment of NSAID-associated gastric ulcers. stinging or tingling erythema. edema. Drug Interaction: The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with Permethrin. Product Guide Dosage and Administration: Adults: two full tube (15 gm) or one full tube (30 gm). For long-term management Omeprazole 10 mg once daily is recommended. increasing to 20 mg if symptoms return. Helicobacter pylori eradication regimens in peptic ulcer disease.182 Indication: Scabies. Disease Gastroesophageal reflux disease including reflux esophagitis Dosage and administration The usual dosage is 20 mg Omeprazole once daily. Dosage & Administration: Capsule and tablet: Omeprazole should be taken before meal. and may also be used for the treatment of gastric ulcer. duodenal ulcers or gastroduodenal erosions. Seclo IV is indicated primarily for the treatment of Zollinger-Ellison syndrome. Healing usually occurred within 8 weeks. Omeprazole has also been used in a dose of 40 mg once daily in patients with reflux esophagitis refractory to other therapy. Patients can be continued at a dosage of 20 mg once daily. Acid reflux disease . For those patients not fully healed after the initial course. duodenal and benign gastric ulcers. prophylaxis of acid aspiration. Seclo® S Active Ingredient: Omeprazole. How to use: Patients >2 months of age can use the dermal cream. healing usually occurs during a further 4-8 weeks treatment. burning. Preparation:15 and 30 gm Cream. Long-term therapy for patients with a history of recurrent duodenal ulcer is recommended at a dosage of 20 mg Omeprazole once daily. The majority of patients with duodenal ulcer are healed after 4 weeks. the recommended dosage of Omeprazole is 20 mg once daily. if needed. healing usually occurs during a further 4 weeks treatment.Product Guide Duodenal and benign gastric ulcers 183 The usual dose is 20 mg Omeprazole once daily. With doses above 80 mg daily. increasing to 20 mg once daily. duodenal ulcers. The recommended dosage of Omeprazole is 20 mg once daily. if symptoms return. The majority of patients with benign gastric ulcer are healed after 8 weeks. More than 90% of patients with severe disease and inadequate response to other therapies have been effectively controlled on doses of 20-120 mg daily. The recommended initial dosage is 60 mg Omeprazole once daily. if needed. For patients considered to be at risk of aspiration of the gastric contents during general anaesthesia. the dose should be divided and given twice daily. For those patients who may not be fully healed after the initial course. In severe or recurrent cases the dose may be increased to 40 mg Omeprazole daily. For the prophylaxis of NSAID-associated gastric ulcers. S For the treatment of NSAIDassociated gastric ulcers. the recommended dosage is Omeprazole 40 mg on the evening before surgery followed by Omeprazole 40 mg 2-6 hours prior to surgery. duodenal ulcers or gastroduodenal erosions Children GERD or other acid-related disorders The recommended dose for pediatric patients 1 years of age and older is as follows: Age > 1 year > 2 year Body Weight 10 . 20 mg once daily 20 mg once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated. Helicobacter pylori eradication regimens in peptic ulcer disease Prophylaxis of acid aspiration Zollinger-Ellison syndrome Omeprazole is recommended at a dose of 40 mg once daily or 20 mg twice daily in association with antimicrobial agents Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for 7 to 14 days. gastroduodenal erosions and dyspeptic symptoms in patients with a previous history of gastroduodenal lesions who require continued NSAID treatment. For prevention of relapse in patients with duodenal ulcer the recommended dose is Omeprazole 10 mg once daily. 40 mg once daily .20 kg > 20 kg Dose 10 mg once daily. Symptom resolution is rapid and in most patients healing occurs within 4 weeks. The solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder. dizziness and headache have been stated to be generally mild and transient and not requiring a reduction in dosage. gastric ulcer or reflux esophagitis Zollinger-Ellison Syndrome (ZES) Product Guide In patients with duodenal ulcer. Use only freshly prepared solution. The solution should be used within 12 hours when Omeprazole is dissolved in saline and within 6 hours when dissolved in 5% dextrose. abdominal colic. paresthesia. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% dextrose for infusion. When gastric ulcer is suspected. Contraindication And Precaution: There are no known contraindications to the use of Omeprazole. After reconstitution the injection should be given slowly over a period of at least 2-5 minutes at a maximum rate of 4 ml per minute. When doses exceed 60 mg daily. The reconstituted solution should not be mixed or co-administered in the same infusion set with any other drug. 40 mg Capsule & 40 mg IV Injection. Direction For Use Of IV Infusion Omeprazole IV infusion 40 mg should be given as an intravenous infusion over a period of 20-30 minutes or more. Secnid® Active Ingredient: Secnidazole. the dose should be divided and given twice daily. Omeprazole IV 40 mg once daily is recommended. Side-Effect: Omeprazole is well tolerated. The solution should be used within 4 hours of reconstitution. S Direction For Use Of IV Injection Omeprazole lyophilized powder and water for injection is for intravenous administration only and must not be given by any other route. . the possibility of malignancy should be excluded before treatment with Omeprazole is instituted as treatment may alleviate symptoms and delay diagnosis.184 IV Injection Duodenal ulcer. Nausea. gastric ulcer or reflux esophagitis where oral medication is inappropriate. diarrhoea. Higher daily doses may be required and the dose should be adjusted individually. Use in Pregnancy & Lactation: Omeprazole can be used during pregnancy. Preparation: 20 mg Capsule & DR Tablet. In patients with Zollinger-Ellison syndrome the recommended initial dose of Omeprazole given intravenously is 60 mg daily. Omeprazole injection 40 mg should be given as a slow intravenous injection. Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used. moderate leukopenia (reversible). Children: 30 mg/kg single dose. If necessary. Children: 30 mg/kg/day. Giardiasis: Adults: 2 gm single dose. taken preferably just before meal. taken preferably just before meal. for 5 days. Trichomoniasis: Adults: 2 gm single dose. 185 Contraindication & Precaution: Hypersensitivity. glossitis. Giardiasis. for 5 days. Rare Side-Effect: Vertigo. Children: 30 mg/kg once daily for only 3 days. The dosage schedule of Secnid suspension is mentioned below: Children of 10 to 15 kg body weight:1 bottle of Secnid 500 Suspension. In the initial weeks of treatment. Use in Pregnancy and Lactation: Secnidazole may be prescribed in pregnancy after the first trimester.Product Guide Indication: Intestinal Amoebiasis.other sulphonylureas. The dosage schedule of is mentioned below: Acute Intestinal Amoebiasis: Adults: 2 gm single dose. Hepatic Amoebiasis. Dosage & Administration: DS tablet: (Secnidazole INN) DS tablet should be administered orally. the risk of hypoglycemia may be increased and necessitates careful monitoring.50 gm/day in a single or divided doses. Urethritis and Vaginitis due to Trichomonas vaginalis. in a single or divided dose. metallic taste. Side Effect: Nausea. taken preferably just before meal. warfarin. taken preferably just before meal.hypersensitivity to Glimepiride. Children of 16 to 25 kg of body weight: 1 & half bottles of Secnid 500 Suspension. S Secrin TM Active Ingredient: Glimepiride Indication: Type 2 diabetes. taken preferably just before meal. other sulphonamides. Preparation : 1 gm DS Tablet and 500 mg Granules for oral Suspension.Patients should be advised not to take alcohol during treatment with secnidazole. should not be used during lactation. Hepatic Amoebiasis: Adults: 1. just before meal.paresthesia. ataxia and motor incoordination. taken preferably just before meal. N. epigastric pain. the daily dose can be increased.and peripheral neuropathy. Evacuation of pus must be performed simultaneously with Secnid (Secnidazole INN) treatment at the suppurative stage of hepatic amoebiasis. B. diabetic precoma or coma. Children of 26 kg or more body weight: 2 bottles of Secnid 500 Suspension. Contraindication and Precaution: Type-I diabetes mellitus. . Asymptomatic Amoebiasis (minute & cystic form): Adults: 2 gm once daily for only 3 days. and stomatitis. Any increase can be based on regular blood sugar monitoring. Secnid 500 Suspension: SecnidSuspension should be administered orally. Children: 35-50 mg/kg single dose. just before meal. should be avoided to patients with a history of blood dyscrasia. The partner should also receive the same treatment concomitantly. and should be gradual. Dosage and Administration: 1 mg once daily. Drug Interaction: Disulfiram. Urticaria. taken preferably just before meal. lowering action of glimepiride unpredictably. Children 1-5 years: Syrup: 2. oestrogens and progestogens. 3 mg & 4 mg Tablet. Drowsiness. temporary visual impairment. Tablet : One tablet (5 mg) once daily. anabolic steroids and male sex hormones. Porphyria or a family history of porphyria contraindicates the use of Sedil. hypotension. Weakening of the blood-sugar-lowering Effect: Acetazolamide. Sedil is a useful premedication . analgesics and anaesthetics.0 mg) once daily or as directed by the physician. allopurinol. Dosage and Administration: Adult & over 12 years: Syrup: 10 ml (2 teaspoonful) once daily. Patients with liver or renal Impairment: A starting dose of one Sedno® Tablet (Desloratadine 5 mg) every other day is Sedil® Active Ingredient: Diazepam. tetracyclines. rifampicin. quinolones. dry mouth. Contraindication & Precaution: Sedil is contraindicated in patients with known history of hypersensitivity to it. gastro-intestinal and visual disturbances. hypnotics. phenytoin. diarrhea. 2 mg. pentoxifylline. beta blockers. miconazole. Side Effect: Infrequent and mild. phenothiazines.186 Side Effect: Hypoglycemia. chloramphenicol. sulfonamides. Both acute and chronic alcohol intake may potentiate or weaken the bloodsugar. diuretics.5 ml (1/2 teaspoonful) daily. Preparation: 1 mg. acute and chronic stress of life. Tablet : 2. coumarin derivatives. antidiabetics. route recommended). Product Guide (I. inattentiveness. oxyphenbutazone. Children 6-11 months : Syrup: 2 ml (1. epinephrine and other sympathomimetic agents. laxatives. fall in blood pressure. Glimepiride must not be taken by breast-feeding women. vertigo. salicylates. MAO inhibitors. fluoxetine. corticosteroids. Children 6-11 years : Syrup: 5 ml (1 teaspoonful) daily. nausea. clonidine and reserpine. skeletal muscle spasm and strychnine poisoning. headedness. ACE inhibitors. urticaria. vomiting. para-aminosalicylic acid. For surgical measures. abdominal pain. Dosage and Administration: Sedil 15 to 30 mg daily in divided doses. Drug Interaction: If diazepam is given concomitantly with centrally acting drugs such as neuroleptics. phenylbutazone. Drug Interaction: Potentiation of the blood-sugar-lowering Effect : Insulin and other oral . Use in Pregnancy and Lactation: Glimepiride must not be taken during pregnancy. barbiturates. Chronic Idiopathic Urticaria.5 mg (half of one 5 mg tablet) once daily. antidepressants.M. Indication: Allergic Rhinitis. the sedative Effects are likely to be intensified. Preparation: 5 mg Tablet and 10 mg/2 ml Injection. diazoxide. S Sedno® Active Ingredient: Desloratadine. ataxia. tranquillizers.H2-receptors antagonists.thyroid hormones. Indication: Anxiety pain from apprehension and depression. In general. At such times. trimethoprim. Azithromycin. trauma. Use in Pregnancy and Lactation: Pregnancy Category C: Combination of Rosiglitazone and Metformin should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. A decision should be made whether to discontinue nursing or to discontinue Desloratadine.Product Guide recommended.g. Combination of Rosiglitazone and Metformin should be used with caution in patients with edema. and vancomycin). fatigue. or to Loratadine. Metformin 187 Indication: Type 2 diabetes mellitus. amiloride. headache. nausea. infection. procainamide.dose selection for an elderly patient should be cautious. Dosage and Administration: For initial therapy: The recommended starting dose of sensimet is 2 mg/500 mg administered once or twice daily. Less common side Effects may include headache. pharyngitis etc. Adverse Reactions: Diarrhea. renal or cardiac function. Drug Interaction: Concomitant administration of Erythromycin.5 mg/5 ml Syrup.000 mg Metformin (total daily dose) plus the dose of Rosiglitazone already being taken. Drug Interaction: Gemfibrozil. Contraindication and Precaution: Hypersensitive to this medication or to any of its ingredients. taking into account the importance of the drug to the mother. ranitidine. vomiting. Precaution: When a patient stabilized on any diabetic regimen is exposed to stress such as fever. Desloratadine should be used during pregnancy only if clearly needed. nausea. But there were no clinically relevant changes in the safety profile of Desloratadine. Fluoxetine and Cimetidine with Desloratadine increased the plasma concentration of Desloratadine. asthenia. triamterene. reflecting the greater frequency of decreased hepatic. rifampin. among the very few adverse Effects commonly reported by small percentage of patients are dry mouth. quinine.. Ketoconazole. Combination of Rosiglitazone and Metformin should not be administered to a nursing woman. Preparation: 5 mg Tablet & 2.For patients inadequately controlled on Metformin monotherapy: Starting dose is 4 mg Rosiglitazone (total daily dose) plus the dose of Metformin already being taken. a temporary loss of glycemic control may occur. and of concomitant disease or other drug therapy. digoxin. Use in Pregnancy and Lactation: Category C. morphine. S Sensimet TM Active Ingredient: Rosiglitazone and . dyspepsia. myalgia. dizziness. or surgery. and somnolence. For patients inadequately controlled on Rosiglitazone monotherapy: Starting dose is 1. Clinical trials suggest a very low rate of adverse Effects associated with Desloratadine administration. Side Effect: In general it is well tolerated. it may be necessary to withhold combination of Rosiglitazone and Metformin and temporarily administer insulin. abdominal discomfort. cationic drugs (e. flatulence. quinidine. indigestion. 4 mg/dL [females] • Acute or chronic metabolic acidosis. the recommended starting dose of this combination is 50 mg sitagliptin/1000 mg metformin hydrochloride twice daily. For patients taking metformin 850 mg twice daily.. such as anaphylaxis or angioedema. Sitagliptin/Metformin combination should generally be given twice daily with meals. including diabetic ketoacidosis. (Rosiglitazone 2 mg and Metformin Hydrochloride 500 mg)/Tablet. haemolytic anaemia or red cell aplasia. especially during pregnancy and lactation. Contraindication & Precaution: Combination (sitagliptin/metformin HCl) is contraindicated in patients with: • Renal disease or renal dysfunction. . Patients treated with an insulin secretagogue or insulin Co-administration of the combination with an insulin secretagogue (e. ≥1. Indications: Treatment and prophylaxis of iron. a few allergic reactions may be seen. • History of a serious hypersensitivity reaction to the combination or sitagliptin.5 mg/dL [males].g. Dosage and Administration: One capsule daily. Indication: Siglimet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate. with gradual dose escalation recommended to reduce gastrointestinal side Effects associated with metformin. folic acid. Vitamin C. However. and tolerability while not exceeding the maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin. Product Guide Dosage & Administration: Dose of this combination should be individualized on the basis of the patient’s current regimen. vitamin B-complex and vitamin C deficiency. Preparation: Capsule. with or without coma. as suggested by serum creatinine levels ≥1.g. The starting dose in patients already treated with metformin should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of metformin already being taken. sulfonylurea) or insulin may require lower doses of the insulin secretagogue or insulin to reduce the risk of hypoglycemia.188 Preparation: (Rosiglitazone 1 mg and Metformin Hydrochloride 500 mg)/Tablet. Folic acid & Vitamin B-complex. Side Effect: Generally well tolerated. to reduce the gastrointestinal (GI) side Effects due to metformin. e. Use in Pregnancy and Lactation: Recommended. Siglimet TM Active Ingredient: Sitagliptin Phosphate Monohydrate & Metformin HCl. with gradual dose escalation. Effectiveness.. Servin® Active Ingredient: Dried Ferrous Sulphate. S Contraindication and precaution: Known hypersensitivity. Care should be taken in hemochromatosis. The recommended starting dose in patients not currently treated with metformin is 50 mg sitagliptin/500 mg metformin hydrochloride twice daily. Siglita™ may be administered without regard to the timing of hemodialysis. the safety of the combination in pregnant women is not known. 189 Siglita TM Active Ingredient: Sitagliptin Phosphate Monohydrate. Indication: For the Management of Type 2 Diabetes Dosage & Administration: 100 mg once daily. nausea/ vomiting. quinidine. morphine.triamterene. Because many drugs are excreted in human milk. ranitidine. . or vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems. Drug Interaction: Co-administration of Digoxin and Sitagliptin may slightly increase the mean peak drug concentration of Digoxin.g. • For patients with mild renal insufficiency (creatinine clearance [CrCl] ≥50 mL/min) no dosage adjustment for Siglita™ is required. trimethoprim. Use in Pregnancy & Lactation: Pregnancy Category B. nasopharyngitis and headache. Contraindication & Precaution: History of a serious hypersensitivity reaction to sitagliptin. Hypoglycemia may occur in patients treated with the combination of Sitagliptin and sulfonylurea and add-on to insulin.flatulence. procainamide. the dose of Siglita is 50 mg once daily.abdominal discomfort. amiloride. quinine. therefore. Co-administration of Digoxin and Sitagliptin may slightly increase the mean peak drug concentration of Digoxin. digoxin. and headache Drug Interaction: Cationic drugs (e. indigestion. • For patients with moderate renal insufficiency (CrCl ≥30 to <50 mL/min). Use in Children: Safety and Effectiveness of Sitagliptin/Metformin in pediatric patients under 18 years of age have not been established Preparation: Siglimet 50/500 & Siglimet 50/1000 tablets. • The recommended dose of SiglitaTM is S Side Effect: The most common adverse reactions are. • For patients with severe renal insufficiency (CrCl <30 mL/min) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis. But no dosage adjustment of digoxin or Sitagliptin is recommended. The combination of sitagliptin & metformin should be used during pregnancy only if clearly needed. But no dosage adjustment of digoxin or Sitagliptin is recommended.There are no adequate and wellcontrolled studies in pregnant women with the combination of Metformin/Sitagliptin or its individual components. upper respiratory tract infection.. the dose of Siglita™ is 25 mg once daily.Product Guide Side Effect: The most common (>5%) adverse reactions due to initiation of metformin therapy are diarrhea. asthenia. caution should be exercised when SiglimetTM is administered to a nursing woman. such as anaphylaxis or angioedema. Siglita™ can be taken with or without food. NURSING MOTHERS: It is not known whether sitagliptin is excreted in human milk. such as rhinorrhea.It moistens dry nasal passages Snizex® Active Ingredient: Azelastine. and sore throat. S Simacor ® Active Ingredient: Simvastatin. Contraindication and Precaution: Hypersensitivity. Contraindication & Precaution: Hypersensitivity to Azelastine HCl or any of its components. Use in Children: Safety and Effectiveness of Sitagliptin in pediatric patients under 18 years of age have not been established. Active liver disease or unexplained persistent elevations of serum transaminases. Use in Pregnancy & Lactation: Azelastine HCl should be administered during pregnancy. . Preparation: Siglita 50 mg & 100 mg Tablet. Indication: Primary hypercholesterolemia. Use in Children: Patients below 5 years of age have not been established. Product Guide Indication: For the treatment of the symptoms of seasonal allergic rhinitis such as rhinorrhea. nasal congestion and postnasal drip. Nursing Mothers: It is not known whether sitagliptin is excreted in human milk. caution should be exercised when Sitagliptin is administered to a nursing woman. Metered dose nasal spray. sneezing. Fredickson Type IIa & IIb dyslipidemia. Children 5-11 years of age: 1 spray in each nostril twice daily. if the potential benefit justifies the potential risks to fetus. drowsiness. loss of sensation. Concurrent use of it with alcohol or other CNS depressants should be avoided because additional reductions in alertness and additional impairment of CNS performance may occur.190 Use in Pregnancy & Lactation: Pregnancy: Pregnancy Category B: Safety of Sitagliptin in pregnant women has not been established. Do not spray in the eyes. Porphyria. nasal burning. Solo TM Active Ingredient: Sodium Chloride 0. Sitagliptin should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus. headache. and nasal pruritus and vasomotor rhinitis. Indication: Solo Nasal Drops is indicated for dry nasal membranes including dry nose resulting from cold and allergy medications. Preparation: 10 mg Tablet. Dosage & Administration: Adult and children 12 years and older: 2 sprays in each nostril twice daily. Pregnancy and breast-feeding. Preparation: 137 mcg/Spray.9%. Because many drugs are excreted in human milk. Dosage and Administration: Simacor tablet 10 mg/day. Side Effect: Bitter taste. Women of child-bearing potential unless adequately protected by barrier contraceptive methods. sneezing. The drug is contraindicated in patients with a history of hypersensitivity to aspirin or any other NSAID . angioedema.. then 250 mg every6 8 hours until attack subsides.which includes those in whom attacks of asthma. Acute gout: 750 mg. polymyxin).50 gm for limiting periods. high levels of sodium (hypernatremia).375 gm total daily dose. Side Effect: No side Effects are expected to occur. 191 Sonap TM Active Ingredient: Naproxen Sodium. children & adults : 2-6 drops into each nostril as needed daily. bacitracin. urticaria or rhinitis have been precipitated by aspirin or any other NSAID. especially of heart problems (e. and previous history of gastro-intestinal ulceration. body cavities) and medical equipment (e. Consult with your doctor before breast-feeding. Naproxen suppository in contraindicated in children under 12 years of age. increased nasal discharge. Contraindication & Precaution:Naproxen should be used with caution in patients with cardiac. This sterile saline solution is also used to cleanse various parts of the body (wounds.Is to be applied 2 . Do not exceed a 1. Dosage & Administration: Infants. direct trauma and fibrositis).g. Contraindication & Precaution: Tell your doctor about your medical history. bursitis. Mild to moderate pain. lung problems (pulmonary edema).ankylosing spondylitis:250 to 500 mg twice daily. Gel . and dysmenorrhoea: 500 mg initially. bandages. Juvenile arthritis (Children over 5 years): 10 gm/kg daily in two divided doses is recommended. The suppository is contraindicated also in patients with any inflammatory lesions of rectum or anus and in patients with recent history of rectal S . primary dysmenorrhoea. hepatic and renal impairment..g. followed by every 250 mg every 6 to 8 hours as required. osteoarthritis.Rheumatoid arthritis. catheters. low levels of potassium (hypokalemia). bursitis. coagulation defect.g. Indication: Rheumatoid arthritis. congestive heart failure).. kidney problems. Dosage and Administration: Tablet & Suppository . and any allergies. migraine and dysmenorrhoea.Product Guide from dry climates or from airplane travel. drainage tubes). acute tendinitis. juvenile rheumatoid arthritis.May be increased to 1. Use in Pregnancy & Lactation: It is unknown if this medication passes into breast milk. However stinging.6 times a day as required and is not recommended for use in children. may help dissolve mucus from stuffy noses and clears the nose after surgery. tendinitis. degenerative arthritis. It is also used as a mixing solution (diluent) for other medications used to irrigate the body (e. ankylosing spondylitis. or salty taste may occur in some cases. acute musculoskeletal disorders (such as sprains. Use in Children: Safe for pediatrics Preparation: Each box contains 10 dropper bottle of 10 ml each. acute gout. presumed infections in SQ-Mycetin® Active Ingredient: Chloramphenicol . tinnitus. fluid retention. Specbac TM Active Ingredient: Meropenem. 500 mg Suppository. vomiting. Urinary Tract Infections. Side Effect:Nausea. Meningitis. vertigo. Hypersensitivity reactions : bronchospasm.headache. propranolol and other betablockers. impairment of renal function. Septicaemia.1 g IV every 8 hours. Indication: Pneumonias and Nosocomial Pneumonias. rashes and angioedema. adult dosage should be used. pruritus. thrombophlebitis. CNS side Effects : drowsiness. Before initiating therapy with meropenem. diarrhoea. Intraabdominal Infections.occasionally bleeding and ulceration. gynaecological infections such as endometritis. Empiric treatment for presumed infections in adult patients with febrile neutropenia and other polymicrobial infections. Product Guide neutropenic patients. thrombocytopenia. peritonitis. In meningitis .25 to 40 mg/kg every 8 hours. nausea. A few instances of jaundice.diarrhoea. Skin reactions like rash. Adverse Effect: Inflammation. urticaria etc. Drug Interaction: ACE inhibitors. Use in nursing mothers must be avoided. Children over 50 kg weight. The co-administration of Specbac with potentially nephrotoxic drugs should be considered with caution. 10% Gel.10 to 20 mg/kg every 8 hours. paraesthesiae. rare hypersensitivity reactions have been reported. Children : Over 3 months to 12 years . careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. S Preparation: 250 mg & 500 mg Tablet.192 or anal bleeding.doses up to 2 gm every 8 hours. headache. Use in Pregnancy and Lactation: The drug should not be used during pregnancy unless clearly needed. and agranulocytosis. In cystic fibrosis. methotrexate. In the treatment of nosocomial pneumonias.500 mg IV every 8 hours. Specbac should not be used in breastfeeding women unless the potential benefit justifies the potential risk to the baby. 4 years to 18 years with cystic fibrosis . In meningitis. Skin and Skin Structure Infections.2 gm every 8 hours. probenecid.40 mg/kg every 8 hours Contra-Indication: Hypersensitivity to this product. sulfonylureas. abdominal pain. Use in Pregnancy and Lactation: Specbac should not be used in pregnancy unless the potential benefit justifies the potential risk to the foetus. septicaemia. Dosage and Administration: Adults : In the treatment of pneumonia. skin and skin structure infections. Gynaecological Infections such as endometritis. coumarin-type anticoagulants. UTI. Precaution: As with all beta-lactam antibiotics. pain at the site of injection. Preparation: 500 mg & 1 gm IV Injection. and photosensitivity. Impaired Active Ingredient: Strontium Ranelate. Contraindication: It is contraindicated in patients with hypersensitivity to Zinc. Parakeratatic skin lesions.5 mg/kg/day. Severe growth retardation. especially for the children from 2 months to 5 years of age in connection with Oral Rehydration Salts (ORS). The granules in the sachets must be taken as a suspension in a glass of water. Night blindness. Rarely optic atrophy in children. Dosage and Administration: Eye : 2 drops every 1-4 hours depending upon the severity. Strontium Ranelate is intended for long-term use. Square Zinc (Zinc Sulfate Monohydrate) is also indicated for the treatment of other Zinc deficiency (Loss of appetite. Preparation: 0. Indication: Stronel is a non-hormonal medicine used to treat osteoporosis in postmenopausal women. For infants between 2 to 6 months of age: 10 mg Zinc once daily for 10-14 days. Deformed bone formation. Acrodermatitis enteropathica. Defective and delayed wound healing. Drug Interaction: Chymotryptin will be inhibited if given simultaneously with Chloramphenicol. Stronel reduces the risk of fracture at the spine and at the hip. For other indications The recommended dose for children is 2 to 2. Adults and children over 30 kg body weight: 40 mg Zinc 1-3 times daily. Contraindication and Precaution: Hypersensitivity or toxic reactions. Blood dyscrasias (granulocytopenia. 193 immunological response.5% Eye/Ear Drops. Zinc Indication: Square Zinc (Zinc Sulfate Monohydrate) is indicated for the treatment of diarrhoea. Dosage & Administration: In the treatment of Diarrhoea Zinc should be given as soon as diarrhoea starts. Children within 10 to 30 kg: 20 mg Zinc 1-3 times daily. Anaemia. Side Effect: Bone marrow hypoplasia. Children under 10 kg: 10 mg Zinc 2 times daily. Use in Pregnancy and Lactation: Use only when considered essential by the physicians. Recurrent respiratory tract Infections. thrombocytopenia and moderate anaemia) may occur after prolonged ophthalmic use. Preparation: 20 mg dispersible tablet S Stronel Sulfate TM Square Zinc® Active Ingredient: Monohydrate. Dosage & Administration: The recommended daily dose is one 2 gm sachet once daily preferably at bed time by oral administration. Ear : 2-3 drops every 3-4 hours. stinging and burning of the eye. sore throat and angioedema. The . vesicular or maculopapular dermatitis.Product Guide Indication: Bacterial infection involving conjunctiva or cornea and otitis externa. For children between 6 months to 5 years of age: 20 mg Zinc once daily for 10-14 days. Mental disturbances). Due to the nature of the treated disease. The most common adverse events consisted of nausea and diarrhoea. Patients may take additional inhalations as required. 200 puffs. Side Effect: Adverse reactions. Product Guide bronchospasm and who require a second bronchodilator. lpratropium + Indication: The management of bronchospasm in patients suffering from chronic obstructive pulmonary disease. insomnia. angina. fatigue. Dosage and Administration: The dose of Sulprex Inhalation Aerosol is two inhalations four times a day. Pediatric Use: Strontium Ranelate is not recommended for use in children and adolescents due to a lack of data on safety and efficacy. Dosage & Administration: Sulprex Nebuliser Solution may be administered from a suitable nebuliser or an intermittent positive pressure ventilator. arrhythmia.194 suspension should be drunk immediately after being prepared. Preparation: Sulprex Inhaler : Each puff delivers 20 mcg of Ipratropium bromide and 100 mcg of Salbutamol. Side-Effect: Overall incidence rates for adverse events with Strontium Ranelate did not differ from placebo and usually mild and generally do not require discontinuation of therapy. dyspepsia. Adults (including elderly patients and children Sulprex TM HFA Inhaler lpratropium + Active Ingredient: Salbutamol. dry mouth. dizziness. the total number of Inhalations should not exceed 12 in 24 hours. it should not be given to nursing women. however. tachycardia. vomiting. As it is excreted in milk. No clinical data on exposed pregnancies are available for Strontium Ranelate. and urinary tract infection/dysuria. hypertension. Preparation: 2 gm granules for oral suspension in sachet. diarrhea. increased sputum. includes edema. palpitation. nervousness. S Use in Pregnancy & Lactation: Strontium Ranelate is only intended for use in postmenopausal women. Contraindication and Precaution: Salbutamol & Ipratropium Bromide combination Inhalation Aerosol is contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean and peanut. arthralgia. Sulprex Nebuliser Solution Active Ingredient: Salbutamol. Contraindication & Precaution: Strontium Ranelate is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product. Indication: Sulprex Inhaler is indicated for use in patients with chronic obstructive pulmonary disease (COPD) & asthma on a regular aerosol bronchodilator who continue to have evidence of . taste perversion. paresthesia tremor. dysphonia. which were generally reported at the beginning of treatment. S Sultolin® Nebuliser Solution Active Ingredient: Salbutamol. 2 mg/5 ml Syrup.myopathy or tachyarrhythmia and in patients with hypersensitivity to ipratropium bromide. Myocardial ischaemia. 195 administered as a single dosage. Less frequent adverse reactions are muscle cramps. and palpitation.5 mg to 5 mg salbutamol up to four times a day. Sultolin syrup: 1-2 mg 3 to 4 times daily. Emphysema. 200 µg DPI Capsule. Cautions to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants. Drug Interaction: Other oral sympathomimetic agents should not be used concommitently. tremor.5 mg)/2.5 mg up to four times a day. Side Effect: Nervousness. and in the treatment of acute severe asthma. Indication: Sultolin Nebuliser Solution is indicated for use in the routine management of chronic bronchospasm unresponsive to conventional therapy. Children 4 years and above: 2. Dizziness. salbutamol sulphate or to atropine or its derivatives. insomnia. it should not be administered to breast-feeding mothers unless the expected benefit is thought to outweigh any possible risk to the neonate. The usual recommended dosage of Sultolin Cozycap for inhalation for adults for maintenance or prophylactic therapy is the contents of one 200 mg capsule every 4 to 6 hours using a revolizer device. tachycardia. Similarly. Contraindication & Precaution: It is contraindicated in patients with hypertrophic obstructive cardio. HFA Inhaler (100 µg/puff ).5 mg to 5 mg up to four times a day. 8 mg SR Tablet. Nervousness. and chest discomfort. The dose may be increased to 5 mg if necessary. Dosage & Administration: Adults (including the elderly): 2. Dosage & Administration: Sultolin tablet: 2-4 mg tablet 3-4 times daily. nausea. headache. unless the expected benefit is thought to outweigh any possible risk to the foetus. headache. Preparation: 4 mg Tablet.Product Guide over 12 years): 1 ampoule three or four times daily. dizziness. Contraindication & Precaution: Hypersensitivity to the active ingradient. Chronic bronchitis. Atrial fibrillation. but Sultolin® Active Ingredient: Salbutamol. Arrhythmia. Up to 40 mg per day can be given under strict medical supervision in hospital. Preparation: (lpratropium 500 mcg + Salbutamol 2. SultolinSR tablet: 8 mg tablet twice daily. Side Effect: Dry mouth. weakness. Not recommended below 2 years of age. Sultolin Cozycap: 1-2 Cozycap may be . Tachycardia. Palpitations. Indication: Bronchial asthma. Cough. Tremor. 10 ampoule.5 ml. Children 18 months to 4 years: 2. especially the first trimester. Use in Pregnancy & Lactation: It should not be used in pregnancy. Nausea. Dysphonia. Sultolin 100 Inhaler : 2 puffs 3-4 tomes daily. the solution may be diluted with sterile normal saline. 1-2 ml solution made upto 100 ml with diluent. Intermittent treatment may be repeated four times a day. The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases.5 ml/5 ml ampoule. Preparation: 5 mg Salbutamol/ml.0-4. Should take about 10 minutes. Contraindication & Precaution: History of hypersensitivity to any of its components.0 ml with normal saline. Sultolin Nebuliser Solution is contra-indicated in patients with a history of hypersensitivity to any of the components. Side Effect: Small increase in heart rate. By Continuous Administration : Sultolin Respirator Solution is diluted with normal saline for injection. As transient hypoxia may occur supplemental oxygen therapy should be considered. It should be used with care in patients known to have received large doses of other sympathomimetic drugs & in thyrotoxicosis.04. T Side Effect: Tachycardia.5 ml of the solution diluted to 2. As salbutamol is probably secreted in breast milk.0 ml should be diluted to final volume of 2.0 ml with normal saline for injection. Children under 12 years age: 0. peripheral vasodilation and fine tremor of skeletal muscle.The diluted solution is administered as an aerosol by a suitably driven nebulizer. . For this 2. Use in Pregnancy & Lactation: Administration of drugs during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. This usually takes 3-5 minutes. Sultolin® Respirator Solution Active Ingredient: Salbutamol Indication: Treatment of severe acute asthma (status asthmaticus) and also forms of bronchospasm in adults & children. Dosage & Administration: By Intermittent Tazid ® Active Ingredient: Ceftazidime. headache. Product Guide Administration : Adult : Sultolin Respirator Solution 0. 20 ml Respirator Solution.0 ml of the solution is placed in the nebulizer and the patient allowed to inhale until bronchodilatation is achieved. However.25 mg (0. It is also Effective in children >18 months. Sultolin Respirator Solution may be used undiluted for intermittent administration.196 medical assessment should be considered since alternative therapy may be indicated. Preparation: Each box contains 10 unit dose of 2. if prolonged delivery time (more than 10 minutes) is required. Tremor. Use in Pregnancy: Unnecessary administration of drugs during the first trimester of pregnancy is undesirable.5-1. The usual rate of administration is 1-2 mg/hour.5 mg up to four times a day.25 mg/kg) to 2. Contraindication & Precaution: Inhaled salbutamol preparations are not appropriate for managing premature labour. Infants under 18 months old: 1. its use in nursing mothers requires careful consideration. Sultolin® Nebuliser Solution is intended to be used undiluted. nausea. Side Effect: Local: phlebitis or thrombophlebitis with IV administration. Preparation: 250 mg. dry mouth and drowsiness. Bone and joint infections. fever. Contraindication: Known hypersensitivity to Cephalosporin antibiotics. 500 mg and 1 gm IM/IV Injection. Indication: Ebastine is indicated for the symptomatic treatment of: • Seasonal and perennial allergic rhinitis • Chronic Idiopathic chronic Urticaria • Allergic skin disorders Dosage & Administration: Adults (more than 12 years of age): 10 mg (one tablet) once daily Children (6-12 years of age): 5 mg (half tablet) once daily Ebastine may be taken with or without food. diarrhea. Pregnancy and Lactation: It should be administered with caution during the early month of pregnancy and early infancy. Skin & soft tissue infections. Use in Pregnancy & Lactation: The safety of ebastine during pregnancy and lactation has not been established Preparation: Each box contains 30 tablets. abdominal pain. Dosage and Administration: 1 to 6 gram per day 8 or 12 hourly (IM/IV) in the majority of infections. Mixed infections. Neonates and children up to 2 months: The usual dosage range is 25 to 60 mg/kg/ day as two divided doses. Ear. clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation. vomiting. given as two or three divided doses. Drug Interaction: Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics. Severe infections in general. candidiasis. Respiratory tract infections. . vaginitis. Contraindication: Patients with a known hypersensitivity to ebastine or any of its ingredients. Infections associated with hemo and peritoneal dialysis and with continuous ambulatory peritoneal dialysis (CAPD). Side Effect: The most common sideEffects are headache. Infants and Children: The usual dosage range for children aged over two months is 30 to 100 mg/kg/ day. Drug Interaction: Concomitant use of ketoconazole. Hypersensitivity: Urticarial rash. itraconazole. Less commonly reported side Effects include abdominal pain. dyspepsia. 197 Tebast TM Active Ingredient: Ebastine. and very rarely oral thrush or colitis. dizziness. T Tesod TM Active Ingredient: Tegaserod. pruritus. pain and/or inflammation after IM injection. biliary and abdominal infections. nose and throat infections.Product Guide Indication: Single infections. and very rarely angioedema and anaphylaxis (bronchospasm and/or hypotension). paraesthesia and bad taste. Gastrointestinal. headache. nausea and insomnia. Dosage and Administration: 6 mg b. candidiasis. Non-gonococcal or non specific urethritis.e. renal impairment. prostatitis. Dosage & Administration: 1-2 g daily given in 2-4 divided doses. Side Effect: Abdominal pain. relapsing fever and V. diarrhea. cholera. during the later half of pregnancy. children : 25-50 mg/kg daily. back pain. Side Effect: Depression of bone growth. in impaired liver function high doses should be avoided. STD. flatulence. Precaution: Diarrhea was reported in some of the patients receiving. isoniazide and sulphonamides) should not be given concomitantly. travelers diarrhoea. fatigue. The Maximum duration of treatment is 12 weeks. as needed. acne vulgaris. chloramphenicol. Contraindication & Precaution: Hypersensitivity. vulnifians. Use in children : not recommended. nausea. urinary tract infections. Ingredient: Levothyroxine Indication: Hypothyroidism . headache. etc. with gradual increments in dose at 6-8 week intervals. syphilis. Brucellosis. Photosensitivity reactions.198 Indication: Symptomatic treatment of irritable bowel syndrome with constipation and abdominal pain or discomfort. bronchitis. anaphylaxis. taken orally 30 minutes before meal. T Preparation: 6 mg Tablet. discoloration of the teeth when given during tooth development (i.i.Primary (thyroidal). anaerobic infections. Indication: Ricketsial infection. Preparation: 500 mg Capsule. Mycoplasma pneumoniae infections. glanders. and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism.d. appears to aggravate pre-existing renal failure. Use of Tegaserod during pregnancy & lactation is not recommended. during infancy and in childhood). PID. Pituitary TSH Suppression Dosage & Administration: Dosing must be individualized and adjustments made based on periodic assessment of the patient’s clinical response and laboratory parameters. epigastric distress and nausea . Miscellaneous infection sincluding granuloma inguinale. Vomiting can occur. Tetrax® Active Ingredient: Tetracycline. Use in Pregnancy and Lactation and Children: Tetracycline should not be used during pregnancy. secondary (pituitary). lactation and in children. urticaria and rashes are uncommon. Esophageal ulcerations. Lyme disease. The dose is generally adjusted in 12. Potentiality hepatotoxic drugs Thyrin® Active Sodium. a) Adult Dosage Initial starting dose: 25-50 mcg/day.5-25 mcg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH . systemic lupus erythematosus. Chlamydial Infections. Product Guide (including erythromycin. 5-25 mcg/day with gradual increment of 25 mcg/ day every 2-4 weeks. tremors. excitement) can . In infants with very low (< 5 mcg/dL) or undetectable serumT4 concentrations..Product Guide has normalized.T4 level is restored to the upper half of the normal range. anxiety. Uncorrected adrenal Levothyroxine has a narrow therapeutic index.Untreated subclinical or overt thyrotoxicosis of any etiology and acute myocardial infarction. Dosage and Administration: One dry powder capsule inhalation twice daily approximately 12 hours apart. the recommended initial starting dose is 50 mcg/day. . T Ticamet TM Cozycap Salmeterol & Active Ingredient: Fluticasone Indication: It is indicated for the long term maintenance treatment of asthma in patient 12 years of age and older. 199 Side-Effect: Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdose . Use in Pregnancy & Lactation: US FDA Pregnancy Category A. excessive sweating. Infants and Children Initial dose is 25 mcg/day with increments of 25 mcg every 2-4 weeks until the desired Effect is achieved. In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: The dose should be titrated until the patient is clinically euthyroid and the serum free. increased blood pressure.or undertreatment. Pregnancy may increase Levothyroxine requirements. palpitations etc. heart rate.7 mcg/kg/ day.7 mcg/ kg/day Contraindication & Precaution: Contraindicated in the following conditions: .The CVS and CNS Effects seen with all sympathomimetic drugs (e. Preparation: 50 mcg Tablet. nervousness. increased appetite. caution should be exercised when it is administered to a nursing woman. Thyroid hormones are excreted minimally in human milk. careful dosage titration is necessary to avoid the consequences of over. In patients with severe hypothyroidism: 12.They include the following: fatigue. Pediatric Use: Can be used. fever. irritability. headache.g. For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1. heat intolerance. muscle weakness. b) Pediatric Dosage Newborns The recommended starting dose is 1015 mcg/kg/day. weight loss. Contraindication and Precaution: Ticamet 100 & 250 Cozycap is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required. So. c) Daily dose per Kg body weight 0-3 months : 10-15 mcg/kg/day 3-6 months : 8-10 mcg/kg/day 6-12 months : 6-8 mcg/kg/day 1-5 years : 5-6 mcg/kg/day 6-12 years : 4-5 mcg/kg/day >12 years but growth and puberty incomplete: 2-3 mcg/kg/day Growth and puberty complete: 1. Oral candidiasis. Use in Pregnancy and Lactation: The drug should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Preparation: 100 mcg (50 mcg + 100 mcg)/DPI and 250 mcg (50 mcg + 250 mcg)/DPI Capsule. cardiac complications. Bronchitis. T Ticamet TM Inhaler Salmeterol and Active Ingredient: Fluticasone Ticas® Active Ingredient: Propionate. Preparation: 50 Inhaler (25 mcg of Salmeterol and 50 mcg of Fluticasone propionate/puff. Hoarseness/ dysphonia. palpitations and headache. Use in Pregnancy and Lactation: Administration of Ticamet Inhaler to pregnant women should only considered if the expected benefit to the mother is greater than any possible risk to the foetus. Due to the fluticasone propionate component. It is also Effective for COPD patients. hoarseness and candidiasis (thrush) of the mouth and throat can occur in some patients. significant hypokalamia in some patients. Diarrhoea and Musculoskeletal pain. Contraindication and Precaution: Hypersensitivity to any of the ingredients. and 250 HFA Inhaler (25 mcg of Salmeterol and 250 mcg of Fluticasone propionate/ puffs. Headache. 120 puffs). 120 puffs). systemic eosinophilic conditions. Fluticasone Indication: Inflammatory and pruritic manifestations of corticosteroidresponsive eczema/dermatitis. angioedema and bronchospasm. chicken pox). Dosage and Administration: Once or twice daily.GI discomfort & pain. 120 puffs). Herpes Simplex. including rash. .200 occur. Dosage and Administration: Adults and adolescents 12 years and older: 2 puffs twice daily. Physicians should be alert to eosiniphilia. Contraindication and Precaution: Rosacea. Perianal Indication: Ticamet is indicated in the regular treatment of asthma. Primary cutaneous viral infections (e. and/or neuropathy presenting in their patients. Sinusitis. Acne vulgaris. with some patients presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome. hypersensitivity reactions.. Product Guide Precautions: Ticamet Inhaler should not be used to treat acute asthma symptoms for which a fast and short acting bronchodilator (Salbutamol) is required. Peri-oral dermatitis. 125 Inhaler (25 mcg of Salmeterol and 125 mcg of Fluticasone propionate/puff.Nausea & vomiting. vasculitic rash. Side Effect: Respiratory tract infection.g. Pharyngitis. where use of a combination (LABA + Steroid) has been found to be appropriate. Side Effect: The pharmacological side Effects of beta2 agonist treatment are tremor. worsening pulmonary symptoms. Bone Marrow Suppression. hypertrichosis and hypopigmentation. hot/cold sensations. Contraindication: Hypersensitivity to any of the components of the product. striae. Dosage and Administration: For adults: 100mg-200mg. Not recommended in adults or adolescents who weigh less than 40 kg because it is a fixed-dose tablet. Side Effect and Precaution: Patients Active Ingredient: Trimebutine Maleate. Adverse reactions: Trimebutine maleate is generally well tolerated. Use in Pregnancy and Lactation: Administration of Fluticasone Propionate during pregnancy & lactation should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. fatigue. Preparation: 100 mg Tablet. It is not known if trimebutine maleate passes into breast milk. Dosage and Administration: Adults and adolescents is 1 tablet twice daily. Drug intracrions: Trimebutine maleate increases the duration of d-tubocurarineinduced curarization. epigastric pain. Indications: Treatment and relief of symptoms associated with irritable bowel syndrome (spastic colon) Postoperative paralytic ileus in order to accelerate the resumption of the intestinal transit following abdominal surgery. 201 drowsiness. constipation. Contraindications: Patients with known hypersensitivity to trimebutine maleate or any excipient. Side Effect: Local burning and pruritus. No other drug interactions have been observed during clinical trials or otherwise reported. Myopathy. Lamivudine and Zidovudine Indication: Alone or in combination with other antiretroviral agents for the treatment of HIV infection. dizziness. Use in Pregnancy and Lactation: The use of trimebutine maleate in pregnant women is recommended. dilatation of the superficial blood vessels. including dermatitis and napkin eruptions.The infrequently reported adverse effects are as follows: dry mouth. atrophic changes in the skin such as thinning. T Timotor Tivizid ® TM Active Ingredient: Abacavir. secondary infection. hypersensitivity appear. .005% Ointment. Preparation: 0.The use of Fluticasone Propionate is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria and dermatoses in children under one year of age. Warning: Hypersensitivity Reaction. diarrhea. etc. foul taste. hypercorticism.Product Guide and genital pruritus. Posttreatment Exacerbations of Hepatitis. dyspepsia. nausea.05% Cream and 0. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants. 3 times per day before meals. headache etc. and other bone marrow suppressive or cytotoxic agents. levels in breast milk following topical application are likely to be very low. Do not use on large areas of the body with any other product containing diphenhydramine.1% Cream. Use in Pregnancy and Lactation: Pregnancy Category C. Indication: Irritant dermatitis. dries the oozing and weeping of poison ivy. Product Guide Dosage & Administration: Adults & children above 2 years: Apply to the affected area 3 to 4 times daily. Lamivudine: Trimethoprim /sulfamethoxazole. breast enlargement. and poison sumac. mothers should be instructed not to breastfeed if they are receiving this combination. Topicort® Active Ingredient: Hydrocortisone Acetate. and 300 mg Zidovudine)/ Tablet. Preparation: Diphenhydramine HCl 2% + Zinc acetate 0. even once taken by mouth. other pyrethroids or pyrethrins. Drug Interaction: Abacavir: Ethanol. Patients with impaired Renal Function. Before application ofcream. poison oak. under the nails and on the soles of the feet. avoid contact of eyes. and poison sumac. Redistribution/ accumulation of body fat including central obesity. Although caution should be exercised in administration of diphenhydramine to nursing mothers. T Togent®  Active Ingredient: Diphenhydramine HCl & Zinc acetate. Because of both the potential for HIV transmission and the potential for serious adverse reactions in nursing infants. facial wasting. doxorubicin or ribavirin. minor burns. Should not have a hot shower or bath before applying. Zalcitabine. Contraindication & Precaution: Use of cream is contraindicated in individuals with a known allergy to its components. Apply the cream lightly on the skin until the cream disappears. minor cuts. and“cushingoid appearance” have been observed in patients receiving antiretroviral therapy. cool and dry.202 with HIV and Hepatitis B Virus Coinfection. Preparation: (300 mg Abacavir. dorsocervical fat enlargement (buffalo hump).teratogenic Effects would not be anticipated. Consult with the physician before use on chicken pox. peripheral wasting. sunburn. rashes due to poison ivy. It is important to include all skin surfaces.However. minor skin irritations. Zidovudine: Ganciclovir. on measles. Indication: Togent cream is used to temporarily relieve pain and itching associated with: insect bites. interferon-alpha. Side Effect: Contact dermatitis with mild erythematous vesicular lesions and papules has occasionally been reported. Allergic . Use in Pregnancy & Lactation: In the absence of specific studies in pregnant women its use in pregnancy should only follow medical advice. When using this product. such as between the fingers and toes. poison oak. drug should be used during pregnancy only if the potential benefits outweigh the risks. scrapes. 150 mg Lamivudine. the skin should be clean. stavudine. headache. 203 hypersensitivity to this drug or other NSAIDs and those patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions. Since ketorolac tromethamine and its metabolites are excreted primarily by the kidney. Drug Interaction: NSAIDs. minor thermal burns. anxiety. pulmonary oedema.Product Guide dermatitis. a history of asthma. excessive thirst. Anticoagulants may cause an enhanced anticoagulant Effect. dyspnoea. chest pain. vomiting. Side Effect: Nausea. Itching and rashes. Preparation: 10 mg Tablet. T Torax® Active Ingredient: Tromethamine. gastrointestinal bleeding. fungal. Contraindication and Precaution: Infections . Ketorolac Indication: Short-term management of moderate to severe acute post-operative pain and acute pain of other origins. hypertension. sunburn. Initial dose is 30 mg IM. skin photosensitivity. Maximum dose is 120 mg/day. Stevens-Johnson syndrome. aspirin. Tablets: 10 mg every 6 hours as required up to 7 days. pruritus. Contraindication: Patients having . Maximum dose is 60 mg/ day. hallucinations. Seborrheic dermatitis. Probenecid. peptic ulcer. where possible as adrenal suppression can occur. Dosage and Administration: Injecetion: For adults (65 years): Initial dose is 60 mg IM (Single). Use in Pregnancy and Lactation: Contraindicated during pregnancy. It is also contraindicated in a history of peptic ulcer or gastro-intestinal bleeding. hypersensitivity. Use in Pregnancy and Lactation: It is recommended that topical corticosteroids should not be used extensively during pregnancy. 30 mg and 60 mg Injection. ulcers or bleeding in patients with or without a history of previous symptoms. For elderly patients (>65 years). pancreatitis. moderate or severe renal impairment. bradycardia. Drug interactions: Should not be used with other NSAIDs or aspirin. fever. flushing. Lichen simplex and Pruritus ani. Maintenance dose is 10-15 mg IM/IV 6 hourly. drowsiness.bacterial. caused by insect bites. injection site pain. Maintenance dose is 30 mg IM/ IV 6 hourly. Preparation: 10 gm Cream. Dosage and Administration: 2 or 3 times daily. Side Effect: Hypersensitivity. In infants and children: Long term topical therapy should be avoided. Flexural Psoriasis. palpitations. 10 mg. fatigue. or in mothers who are breast feeding. anticoagulants. insomnia. asthma. malaise. Ketorolac tromethamine can cause gastro-intestinal irritation. inability to concentrate. The maximum duration of treatment should not exceed two days. infertility in female. urticaria. viral. etc. dizziness. Lyell’s syndrome. labour or delivery. skin ulcers. patients with moderate to severe impairment of renal function (serum creatinine greater than 160 micromol/l) should not receive. Eczema. methotrexate. melaena. Initiated with 15 mg or 30 mg once daily. acute rhinitis. Digoxin. angioneurotic oedema or urticaria following the administration of acetylsalicylic acid or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Drug Interaction: Oral anticoagulants. . Pioglitazone should be used with caution in case of combination antidiabetic therapy and hepatic insufficiency. rheumatoid arthritis: 90 mg. Indication: Type 2 diabetes mellitus. Use in Pregnancy and Lactation: Pioglitazone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Tos TM Active Ingredient: Pioglitazone. diuretics and ACE inhibitors.204 Product Guide Use in Pregnancy and Lactation: It should be avoided in late pregnancy because it may cause premature closure of the ductus arteriosus. rheumatoid arthritis. Cyclosporin and Tacrolimus. severe congestive heart failure. Preparation: 60 mg. Indication: Relief of pain and inflammation in . edema. It is not known whether this drug is excreted in human milk. Tory® Active Ingredient: Etoricoxib. chronic musculoskeletal disorders & dysmenorrhoea: 60 mg. drugs metabolized by CYP isoenzymes. Methotrexate. patients who have developed signs of asthma. oral contraceptives. Lithium. 90 mg & 120 mg Tablet. & following dental surgery. fatigue. Rifampicin. Contraindication and Precaution: Known hypersensitivity to this product or any of its components. other chronic musculoskeletal disorders. and Antacids. Side Effect: Dry mouth. It should not be used in type 1 diabetes or for the treatment of diabetic ketoacidosis. T Contraindication and Precaution: Known hypersensitivity to Etoricoxib. It should not be administered to a breast feeding woman. drugs metabolized by sulfotransferases (Ethinyl Estradiol). Dosage and Administration: Adult and adolescent over 16 years: osteoarthritis. acute gout. appetite and weight changes. myalgia. sinusitis. pharyngitis. to children and adolescents under 16 years of age.osteoarthritis. etc. Side Effect: Upper respiratory infection. Drug Interaction: Oral contraceptive containing ethinyl estradiol and norethindrone. dysmenorrhoea. patients with active peptic ulceration or gastrointestinal (GI) bleeding. chest pain. tooth disorder. pain following dental surgery & acute gout: 120 mg. patient having inflammatory bowel disease. mouth ulcers. Dosage and Administration: Once daily without regard to meals. It should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the foetus. flatulence. constipation. taste disturbance. influenza-like syndrome & myalgia. nasal polyps. Ketoconazole. once daily. paraesthesia. headache. Prednisone/Prednisolone. Acetylsalicylic acid. once daily. once daily. which can exacerbate or lead to congestive heart failure. Based on the usual starting doses of Glimepiride (1 mg or 2 mg once daily). therapy with Combination of Pioglitazone and Glimepiride should be discontinued. liver enzyme levels should be rechecked as soon as possible. and adjusted after assessing adequacy of therapeutic response. Combination of Pioglitazone and Glimepiride should be used with caution in patients at risk for heart failure. Tosirin may be initiated with 30 mg/2 mg or 30 mg/4 mg tablet strengths based on the dose of pioglitazone and Glimepiride already being taken. This condition should be treated with insulin. Starting dose for patients currently on pioglitazone monotherapy. If at any time ALT levels increase to >3X the upper limit of normal in patients on therapy with Combination of Pioglitazone and Glimepiride. If any patient develops symptoms suggesting hepatic dysfunction. Hepatic Effects: Liver enzymes should be checked prior to the initiation of therapy with Combination of Pioglitazone and Glimepiride in all patients and periodically thereafter per the clinical judgment of the healthcare professional. Dosage & Administration: Selecting the starting dose of Tosirin should be based on the patient’s current regimen of pioglitazone and/or sulfonylurea. Since thiazolidinediones. and anorexia. • Diabetic ketoacidosis.5X upper limit of normal). Contraindication Combination of & Precaution: Pioglitazone and T . The mechanism of weight gain is unclear but probably involves a combination of fluid retention and fat accumulation. including Pioglitazone can cause fluid retention. Based on the usual starting dose of pioglitazone (15 mg or 30 mg daily). which may include unexplained nausea. Weight Gain: Dose-related weight gain was seen with Pioglitazone alone and in combination with other hypoglycemic agents. 205 Glimepiride is contraindicated in patients with: • Known hypersensitivity to Pioglitazone or Glimepiride or any of the components of combination of Pioglitazone or Glimepiride. Therapy with Combination of Pioglitazone and Glimepiride should not be initiated in patients with increased baseline liver enzyme levels (ALT >2. Starting dose for patients switching from combination therapy of pioglitazone plus Glimepiride as separate tablets. It is recommended that a single dose of Tosirin be administered once daily with the first main meal. If ALT levels remain >3X the upper limit of normal. vomiting. and pioglitazone 15 mg or 30 mg.Product Guide Preparation: 15 mg & 30 mg Tablet. Tosirinmay be initiated at 30 mg/2 mg once daily. Edema: Combination of Pioglitazone and Glimepiride should be used with caution in patients with edema. with or without coma. abdominal pain. and/or dark Tosirin TM Active Ingredient: Pioglitazone and Glimepiride Indication: Tosirin is indicated as an adjunct to diet and exercise as a once-daily combination therapy to improve glycemic control in patients with type 2 diabetes. fatigue. Tosirin may be initiated at 30 mg/2 mg or 30 mg/4 mg tablet strengths once daily. and adjusted after assessing adequacy of therapeutic response. Starting dose for patients currently on Glimepiride monotherapy. furuncles. confusion etc. flatulence.While taking Levofloxacin. Uncomplicated & complicated skin and soft tissue infections including abscesses. Uncomplicated UTI. Trevox® Active Ingredient: Levofloxacin. Community-acquired pneumonia. depression. 250500 mg once daily for 7 days. 500 mg once daily for 10-14 days. Inhalation anthrax (post-exposure): To prevent the development of inhalational anthrax following exposure to Bacillus anthracis. phototoxicity. Acute bacterial exacerbation of Chronic bronchitis. adequate amount of water should be taken to avoid concentrated form of urine. Dose adjustment should be exercised during Levofloxacin ingestion in presence of renal insufficiency. 750 mg once daily for 7-14 days.206 urine. moderate and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed below• Pneumonia: Nosocomial and community acquired • Acute bacterial sinusitis • Acute bacterial exacerbation of chronic bronchitis . Uncomplicated skin and soft-tissue infections. Side Effect: Nausea. 500 mg once daily for 28 days. 500 mg once daily for 7-14 days. cellulitis. Warfarin. Complicated urinary tract infections. Indication: Acute maxillary sinusitis. Preparation: (Pioglitazone 30 mg + Glimepiride 2 mg)/ Tablet & (Pioglitazone 30 mg + Glimepiride 4 mg)/ Tablet Product Guide daily for 7-10 days. tremors. 750 mg once daily for 5 days. liver enzymes should be checked. Acute pyelonephritis. Complicated urinarytract infections and acute pyelonephritis. Contraindication and Precaution: Hypersensitivity. Chronic bacterial prostatitis. Acute pyelonephritis. impetigo. Preparation: 500 mg & 750 mg Tablet. Dosage and Administration: Acute sinusitis. Inhalation anthrax (post-exposure): Adult500 mg once daily for 60 days. as the Effects on the unborn child or infant are unknown. Community-acquired pneumonia. pyoderma. 250 mg once daily for 10 days. Iron. 750 mg once daily for 7-14 days. 125 mg/5 ml Oral Solution. NSAID. 250 mg once daily for 3 days. Complicated skin and soft-tissue infections. Use in Pregnancy & Lactation: Combination of Pioglitazone and Glimepiride should not be used during pregnancy and lactation. 250 mg daily for 7-10 days. abdominal pain. Uncomplicated UTI. wound infections. Drug Interaction: Antacids. diarrhea. Nosocomial Pneumonia. Communityacquired pneumonia. Chronic bacterial prostatitis. Use in Pregnancy and Lactation: Not recommended for use during pregnancy or nursing. Nosocomial Pneumonia. vomiting. Exacerbation of chronic bronchitis. 500 mg once T Trevox 500 IV TM Active Ingredient: Levofloxacin 500 mg as Levofloxacin Hemihydrate INN. Indication: Levofloxacin infusion is indicated for the treatment of mild. plasma concentrations are likely to predict efficacy. constipation. a decision should be made whether to discontinue nursing or to discontinue the drug. Disturbances of blood glucose. no fluoroquinolone should be co-administered with any solution containing multivalent cations. palpitation.Not tested in humans for post-exposure prevention of inhalational anthrax. hypoglycemia.. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Contraindication & Precaution: Levofloxacin is contraindicated in persons with known hypersensitivity to levofloxacin or other quinolone antibacterials. dyspepsia. Elevations of the prothrombin time in the setting of concurrent warfarin and Levofloxacin use have been associated with episodes of bleeding. anxiety.1 to 1%) side Effects include allergic reaction. However. edema and injection site reaction. abdominal pain. Drug Interaction: There are no data concerning an interaction of intravenous fluoroquinolones with oral antacids. Use in Pregnancy & Lactation: There are no adequate and well-controlled studies in pregnant women. vomiting. may increase the risk of CNS stimulation and convulsive seizures.g. including Levofloxacin. tremor. magnesium. hyperglycemia. diarrhea. Side Effect: Headache.Product Guide 207 • Skin and skin structure infections: Complicated and uncomplicated • Chronic bacterial prostatitis • Urinary tract infections: Complicated and uncomplicated • Acute pyelonephritis • In halational anthrax. agitation. including hyperglycemia and hypoglycemia. abnormal hepatic function.or metal cations. e.post-exposure. through the same intravenous line. Less common (0.didanosine. Based on data on other fluoroquinolones and very limited data on Levofloxacin. Dosage & Administration: Type of Infection Dosed Every 24 hours 750 mg 500 mg or 750 mg Duration (days) T Nosocomial Pneumonia Community Acquired Pneumonia 7-14 7-14 5 .multivitamins. The concomitant administration of a non-steroidal anti-inflammatory drug with a fluoroquinolone.sucralfate. tendonitis etc. have been reported in patients treated concomitantly with fluoroquinolones and an anti-diabetic agent. Because of the potential for serious adverse reactions from Levofloxacin in nursing infants. nausea. taking into account the importance of the drug to the mother. it can be presumed that levofloxacin will be excreted in human milk. Levofloxacin may enhance the Effect of warfarin. 208 Acute Bacterial Sinusitis 500 mg or 750 mg Acute Bacterial Exacerbation of Chronic 500 mg Bronchitis Complicated Skin and Skin Structure 750 mg Infections Uncomplicated SSSI Chronic Bacterial Prostatitis Complicated Urinary Tract Infection or Acute Pyelonephritis 500 mg 500 mg 250 mg or 750 mg Product Guide 7-14 5 7 7-14 7-10 28 10 5 3 Uncomplicated Urinary Tract Infection 250 mg T In each case. Trispray® Active Ingredient: Triamcinolone Acetonide. Contraindication: No contraindication. sequential therapy (intravenous to oral) may be instituted at the discretion of the physician. Preparation: Trevox 500 IV: Each box contains 1 bag of 100 ml solution for intravenous infusion. safety and efficacy have not been established in children in children younger than 6 mo of age. Dosage and Administration: Adults and children 12 years and older :The recommended dose is 2 sprays in each nostril once daily. naso-sinus congestion. Adverse Reactions: Rhinitis. nasal septal perforation has been . pharyngitis. headache. sneezing. Below 6 years: Not recommended. 6-12 years: 1 spray in each nostril once daily. Indication: Treatment and prophylaxis of the nasal symptoms of seasonal and perennial allergic rhinitis from 6 years of age to adults. Use in Children: Except for inhalational anthrax (postexposure). epistaxis. nasal irritation. dry mucous membrane. Use in Pregnancy & Lactation: Pregnancy category B. Headache and diarrhoea are the most common side Effects and rarely included abdominal pain. Preparation: 55 mcg/spray. Side-Effect: Pantoprazole is well tolerated in both short term and long term treatment. Nasal Spray. Precaution: If there is any reason to suppose that adrenal function is impaired. ulcer resistant to H2 receptor antagonists. eradication of Helicobacter pylori (in combination with Antibiotics). care must be taken while transferring patients from systemic steroid treatment to Triamcinolone.Product Guide reported. Eradication of Helicobacter pylori Ulcer resistant to H2 receptor antagonists . continued for further 4 weeks if not fully healed 40 mg daily in the morning for 2 weeks. continued for further 4 weeks if not fully healed Trupan® Active Ingredient: Pantoprazole. A decision should be made whether to discontinue nursing or to discontinue the drug. Patients should be cautioned that Pantoprazole tablet should not be split. acid hypersecretory conditions including Zollinger-Ellison Syndrome.duodenal ulcer. increased to 40 mg daily if symptoms return. daily doses above 80 mg given in two divided doses 40 mg twice daily by triple therapy with Antibiotics 40 mg once daily for 8 weeks.maximum 40 mg daily). Pantoprazole should be used during pregnancy only if clearly needed. flatulence. gastroesophageal reflux disease (GERD). 20 mg daily as a maintenance therapy. Duodenal ulcer GERD T NSAIDs induced 20 mg daily peptic ulcer Acid hypersecretory conditions including Zollinger-Ellison Syndrome Initially 80 mg once daily adjusted according to response (Elderly . rash.Benign gastric ulcer. crushed or chewed. Dosage & Administration: Tablet Disease Benign gastric ulcer Dosage and administration 40 mg daily in the morning for 4 weeks. NSAID-induced peptic ulcer. Drug Interaction: None is known. Indication: Trupan is indicated for the treatment of . Contraindication & Precaution: Pantoprazole is contraindicated in patients with known hypersensitivity to the active drug or any other components of the formulation. insomnia and hyperglycemia. continued for further 2 weeks if not fully healed 20-40 mg daily in the morning for 4 weeks. 209 taking into account the benefit of the drug to the mother. The admixed solution may be stored at o room temperature (up to 30 c) and must be used within 24 hours from the time of initial reconstitution. constipation. Preparation: 20 mg Tablet. 40 mg Tablet and 40 mg IV Injection.210 Children: Safety and effectiveness have not been established Product Guide 2-5 minutes. may increase to 80 mg every 8 hours if needed. prostatic hypertrophy. mania. arrythmias. Indication: Depressive illness. urinary retention. particularly with anxiety and nocturnal enuresis in children. Pantoprazole IV should be reconstituted with 10 ml of 0. increased Intravenous Pantoprazole should be replaced with oral therapy as soon as possible. particularly heartblock of any degree. Tryptin® Active Ingredient: Amitriptyline.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route.9% Sodium Chloride Injection to the vial containing powder. hepatic impairment. Direction For Use Of IV Injection: Pantoprazole lyophilized powder and 0. glaucoma.9% Sodium Chloride Injection or Lactated Ringer’s Injection. Dosage and Administration: 25-50 mg a day in divided dose. followed rebleeding in peptic by 8 mg/hour infusion for 72 ulcer hours T Prophylaxis of acid 80 mg IV every 12 h aspiration for 24 h. may titrate to higher doses depending on acid output. Pantoprazole injection 40 mg should be given as a slow intravenous injection. Injection Duodenal ulcer and 40 mg once daily gastric ulcer for 7-10 days Gastroesophageal 40 mg once daily reflux disease for 7-10 days associated with a history of erosive esophagitis Prevention of IV 80 mg. Caution in patients with a history of epilepsy. Contraindication & Precaution: Myocardial infarction. Direction For Use Of IV Infusion: Pantoprazole IV 40 mg should be given as an intravenous infusion over a period of approximately 15 minutes.9% Sodium Chloride Injection and further diluted (admixed) with 5% Dextrose or 0. pregnancy. After reconstitution the injection should be given slowly over a period of at least . followed by 40 mg every 12 h Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions 80 mg IV every 12 hours. cardiac disease. severe liver disease. Use only freshly prepared solution. The reconstituted solution may be stored o at room temperature (up to 30 c) for a maximum 4 hours prior to further dilution. The reconstituted solution may be stored at room temperature (up to o 30 c) for a maximum 4 hours. thyroid disease. The solution for IV injection is obtained by adding 10 ml 0. diabetes. hallucination. weakness. tachycardia. Dosage and Administration: 2 mg b. breast enlargement. 6-12 years: 1 teaspoonful 3 times a day.urinary retention. impaired renal function. Indication: Treatment of overactive bladder with symptoms of urinary urgency. increased intraoccular pressure. syncope. frequency. dryness of mouth. isoprenaline. warfarin. pseudoephedrine or triprolidine.25 mg)/5 ml Syrup.d. Testicular swelling. oral contraceptives. Drug Interaction: Concomitant use with decongestants. hyperplasia. 211 until they have determined their own response. disorientation. and hallucinations. dyspepsia and/or reduced lacrimation. Side Effect: Dryness of mouth. appetite suppressants and amphetaminelike psychostimulants or with MAO inhibitors may occasionally cause a rise in blood pressure. Urinary retention decreased gastrointestinal motility. psychoses (may aggravate mania). tachycardia. and/or urge incontinence. impaired hepatic function. skin rashes. Patients should not drive or operate machinery . Drug Interaction: Monoamine oxidase inhibitors. blurred vision.Product Guide intra-occular pressure. epigastric distress. Dizziness. Preparation: (100 mg + 30 mg + 1. vomiting anorexia. epinephrine. Side Effect: Hypotension. uncontrolled narrow angle glaucoma. sleep disturbance. Alcohol. Dry mouth. delusions. excitation. diarrhoea. Pseudoephedrine and Triprolidine. hypertension. postural hypotension. Dosage and Administration: Adults: 2 teaspoonful 3 times a day. nose and throat. CNS depressant. headache. Children : Over 12 years: 2 teaspoonful 3 times a day. Bone-marrow depression. Use of tolterodine during lactation TM U Tusca® Active Ingredient: Guaiphenesin. Ucol 2 Active Ingredient: Tolterodine Tartrate. urticaria. tricyclic antidepressants. and photosensitization. weight loss. noradrenaline. Confusional states. Gastrointestinal: Nausea. and heart block stroke. drowsiness. adrenaline. Cemitidine. arrythmias. galactorrhoea. fatigue. Pregnancy and Lactation: Should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. myocardial infarction. Contraindication & Precaution: Urinary retention. Indication: Symptomatic relief of upper respiratory tract disorders accompanied by productive cough. Side Effect: CNS depression. Skin rash. known hypersensitivity. Drug Interaction: Ketoconazole. gynaecomastia. palpitations. 2-6 years : 1/2 teaspoonful 3 times a day.i. mydriasis. Preparation: 10 mg and 25 mg Tablet. Contraindication & Precaution: Hypersensitive to guaiphenesin. Dose may be increased by 200mg/day at 3 days interval to a maximum of 2. Tachycardia. Contraindication & Precaution: Sodium valproate is contra-indicated in patients with known hypersensitivity of sodium valproate. This is contraindicated for use in women and children (under the age 18). Dry mouth. Product Guide with other alpha-blockers. Maintenance dose: Usually 1-2g daily (2030 mg/kg daily). Abdominal pain. ataxia & tremor. Indication: Headache Epilepsy. Cimetidine. Dosage and Administration: BPH: 10 mg once daily immediately after the same meal each day. Drug Interaction: Alfuzosin may interact Valoate® Active Ingredient: Sodium Valproate. Malaise. The treatment should be continued for 3-4 days (2-3 days during catheterization and 1 day after its removal). Dose may be increased in severe cases with proper monitoring of plasma concentration. Side Effect: Dizziness. These actions may lead to an inappropriate release and absorption of the drug and therefore possible early adverse reaction. Headache. Contraindication: Hypersensitivity to Alfuzosin. in combination with other alphablockers. Rash.212 should be avoided. Dose should be started from the first day of catheterization. Chronic V Dosage & administration: Adults: Initial: 600mg/day in 2 divided doses. Alfuzosin Indication: Uriten is used for the treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH). nausea. hyperammonaemia. Mania.5g daily in divided doses until control of seizure is achieved. preferably after food. Diarrhea. . Diltiazem. personal or family history of severe active liver disease hepatic dysfunction. Postural hypotension. Syncope. Atenolol. porphyria and known urea cycle disorder. The tablet should be swallowed whole. Fatigue. Side Effect: Gastric irritation. Use in Pregnancy and Lactation: Alfuzosin should not be used by women.The tablets should not be chewed or crushed. Nausea. Preparation: 2 mg Tablet. moderate and severe liver problem. Children (over 20kg): Initial: 400mg/ day (irrespective of weight). Children (up to 20kg): Initial: 20mg/ kg daily in divided doses. history of orthostatic hypotension. Dose may be increased by 20-30 mg/kg if required to achieve control. AUR: 10 mg once daily immediately after the same meal each day. Vertigo. Palpitation. Ketoconazole and Ritonavir. Uriten TM Active Ingredient: hydrochloride. Preparation: 10 mg Extended Release Tablet. It is also used as a short term treatment of acute urinary retention (AUR) related to BPH patients (over 65 years) in association with catheterization. rarely lethargy and confusion and also increased alertness. irregular periods. Contraindication & Precaution: Known allergy to the cephalosporin class of antibiotics. Drug Interaction: Antacids. vomiting and abdominal pain). Warfarin. fibrinogen reduction. V Vanprox TM Active Ingredient: Cefpodoxime. oedema. Aspirin etc most significantly interacts with sodium valproate Use in Pregnancy & Lactation: D Use in Children: Can be used for children Preparation: 200 mg. rash. dementia. Skin & soft tissue infections. Over 9 years : 100 mg every 12 hours. Childhood infections. transient hair loss. Steven’sJohnson syndrome. impaired hepatic function leading rarely to fetal hepatic failure. H2-blockers. red cell hypoplasia. Drug Interaction: Sodium valproate is a non specific inhibitor of drug metabolism. Phenobarbital. amenorrhoea. rarely pancreatitis. rashes. 6 months-2 years : 40 mg every 12 hours. Fancoli’s syndrome. 213 Acute bacterial exacerbation of chronic bronchitis 400 mg 200 mg 12 hourly 10 days Uncomplicated gonorrhea (men/women) 200 mg Single dose. and vasculitis have also been reported. Pharyngitis and/or tonsillitis 200 mg 100 mg 12 hourly 5-10 days Uncomplicated urinary tract infection 200 mg 100 mg 12 hourly 7 days Acute maxillary sinusitis 400 mg 200 mg 12 hourly 10 days Child : 15 days-6 months : 4 mg/kg every 12 hours. leucopenia. nausea. Urinary tract infections including gonorrhoea. hearing loss. Phenytoin. In patients with transient or persistent reduction in urinary output due to renal insufficiency. prolonged use of Cefpodoxime may result in overgrowth of nonsusceptible organisms. toxic epidermal necrolysis. Gynecological infections. gynaecomastia. 300 mg & 500 mg CR Tablet and 200 mg/ 5 ml Syrup. Dosage and Administration: Adults (Including age 13 years & older): Type of infection Total daily dose Dose Frequency Duration Acute community-acquired pneumonia 400 mg 200 mg 12 hourly 14 days . If superinfection occurs during therapy. the total daily dose of Cefpodoxime should be reduced because high and prolonged serum antibiotic concentration can occur in such individuals following usual doses. Side Effect: Gastrointestinal disorders (such as diarrhoea. As with other antibiotics. thrombocytopenia. 3-8 years: 80 mg every 12 hours.Product Guide increased appetite & weight gain. pancytopenia. appropriate measures should be taken. A decision should be made whether to discontinue breast feeding or to discontinue the drug. Upper respiratory tract infections. Acute otitis media. cystitis. Use in Pregnancy & Lactation: The drug should be used during pregnancy only if clearly needed. sedation. Rectal gonococcal infection in women 200 mg Single dose. and inhibition of platelet aggregation. Indication: Lower respiratory tract infections. urticaria and itching. Skin and soft tissue infections: 200 mg twice days. Heart failure (adjunct) and asymptomatic left venticular disfunction: Initially 2. 80 mg/5 ml Suspension. Treatment of urinary retention: 1 ml of the 1:2000 solution (0. syncope. Safety and Effectiveness of the drug have not been established in children. angina. patient should be observed under medical supervision for at least two hours and until blood pressure has been stabilized. Side Effect: Dizziness and headache. muscle cramps. Fatigue and asthenia.5 mg) intra-muscularly V . dialysis. Vasopril® Active Ingredient: Enalapril. diarrhoea or vomiting.214 Probenecid. renal failure and oliguria. Versia TM Active Ingredient: Neostigmine Methyl Sulphate.5-5 mg once daily up to 20 mg daily if used in addition to diuretics. The risk of hypotension is also present in patients undergoing major surgery or during anesthesia with agents that produce hypotension. Preparation: 5 mg and 10 mg Tablet. Hypotension may result shortly after initiation of the treatment in patients with severe heart failure or those who have been volume depleted by diuretic therapy. then 20mg daily in 1-2 divided doses.5 mg) intramuscularly or subcutaneously or as required. Product Guide diarrhoea. renal dysfunction. Prevention of post-operative distention and urinary retention: 1 ml of the 1:4000 solution (0. Indication: Hypertension and renovascular hypertension.5 mg) intramuscularly or subcutaneously. 40 mg/5 ml Suspension. congestive heart failure (adjunct). Dosage and Administration: 2. coronary ischaemic events. nausea. 20 mg/ml Paediatric Drops.25 mg) intramuscularly or subcutaneously as soon as possible after operation. Indication: Versia Injection is used for of non-depolarizing • Reversal neuromuscular blockade for surgical anesthetic procedures • The prevention and treatment of postoperative distention and urinary retention after mechanical obstruction has been excluded • Treatment of the systemic control of Myasthenia gravis when oral therapy is impractical Dosage & Administration: Adults: By intramuscular or subcutaneous injection: Symptomatic control of myasthenia gravis: 1 ml of the 1:2000 solution (0. dose should be adjusted if the patient is found to have renal insufficiency. diabetic nephropathy and Raynaud’s disease. Angioedema. orthostatic hypotension. rash and cough. Nephrotoxic drugs.5 mg. dietary salt restriction. hypotension. hyperkalemia and hyponatremia. repeat every 4-6 hours for 2-3 days. Contraindication & Precaution: Hypersensitivity. heart failure. Preparation: 100 mg & 200 mg Capsule. Subsequent dose should be based on the individual patient’s response. Treatment of post-operative distention: 1 ml of the 1:2000 solution (0. nystagmus.agitation. Children: 200-500 micrograms as recommended.Product Guide or subcutaneously. diarrhea and abdominal cramps (more marked with high doses). After the patient has voided. Atropine or other antidote to muscarinic effccts may be necessary (particularly when Neostigmine is given by injection). Meclizine & Indication: For prophylaxis and symptomatic relief of nausea. each 1 ml containing Neostigmine Methyl Sulphate USP 0. recent myocardial infarction. On exceptional cases total dose should be exceed 5 mg.6-1. when Neostigmine is administered intravenously. motion sickness. Vertigo: One tablet two times daily or as directed by physician. The usual dose is 0. increased salivation. But use during lactation hasn’t been determined. bronchial secretions and sweating.bradycardia. or the bladder has been emptied. Radiation sickness: 50 mg (Meclizine HCl) administered 2 to 12 hours prior to radiation treatment.miosis. continue the 0. Dosage & Administration: Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily or as directed by physician.5 mg (each box contains 10 ampoules in blister packaging). hypotension. for at least 5 injections. Contraindication & Precaution: Neostigmine is contraindicated in patients with known hypersensitivity to the drug. Labyrinthine and vestibular disturbances: The optimal dose of Meclizine HCl is usually 25 to 100 mg daily in divided doses. hypotension. bradycardia.5 to 2 mg is given by slow intravenous injection. the dose may be repeated every 24 hours as indicated for the duration of journey. vomiting. vagotonia.g. Therefore. Contraindication & Precaution: The fixed-dose combination is contra-indicated V . Asthma. It is also contraindicated in patients with peritonitis or mechanical obstruction of the intestinal or urinary tract.labyrinthitis and other vestibular disturbances) and morning sickness during pregnancy. Meniere’s syndrome. the patient should be catheterized. radiation sickness and vertigo associated with diseases of vestibular system (e. Pyridoxine (vitamin B6) has been shown to be safe and Effective in dosages of 50 to 200 mg per day. Use in Pregnancy & Lactation: Pregnancy 215 category C. If urination does not occur within an hour. Signs of overdose are increased gastrointestinal discomfort. Preparation: IM/IV Injection. but it should not be given routinely as it may mask signs of overdose. it should be taken one hour prior to journey for protection against motion sickness. involuntary defecation and micturition. parkinsonism. epilepsy. peptic ulceration.5 mg injection every 3 hrs. it is recommended that Atropine Sulphate (0. dizziness.excessive dreaming and weakness eventually leading to fasciculation and paralysis. vomiting. Vertina Plus TM Active Ingredient: Pyridoxine. Neonates: 50-250 micrograms every 4 hrs. depending on the clinical response. Motion sickness: The initial dose is one or two tablets daily.2 mg) also be given intravenously using separate syringe. repeated as required. Side Effect: Nausea. Reversal of Effects of Non-depolarizing Neuromuscular Blocking Agents. Side Effect: Local skin reactions. dry mouth. patient with asthma. minor cuts and wounds. mouth wash for acute mucosal infection for mouth and pharynx. For the prophylaxis of herpes simplex infections in immunocompromised patients. Prevention of recurrence of herpes simplex: V Viodin® Active Ingredient: Povidone-Iodine Indication: Primary or secondary topical infections. and infected traumatic lesions. Side-Effect: Drowsiness. Special caution is needed when regular applications to broken skin are made to patients with pre-existing . Preparation: 1% (50 mg/5 ml) Mouthwash/Gargle. For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. Dosage and Administration: Once or twice daily or at dressing change. hypernatraemia and impairment of renal function. Regular use should be avoided in patients on concurrent lithium therapy. Indication: For the treatment of viral infections due to Herpes simplex virus (type I & II) and Varicella zoster virus (herpes zoster & chickenpox). Infants under 2 years. Use in Pregnancy & Lactation: Indicated. Preparation: Meclizine HCl 25 mg & Pyridoxine HCl 50 mg film coated Tablet. incisions and other topical lesions. Virux® Active Ingredient: Aciclovir. Children under 2 years: half of the adults dose. enlarged prostate. increase dose to 800 mg 5 times daily for genital herpes in immuno-compromised) or as directed by the registered physician. bronchitis. 5 % (50 mg/gm) Ointment. Due to its potential anticholinergic action. Children over 2 years: Adult dose. 15 ml and 100 ml 10% (500 mg/5 ml) Solution. infected surgical incisions. Sensory neuropathy reported with high dosage of Pyridoxine hydrochloride given for extended periods. Contraindication and Precaution: Hypersensitivity. urinary retention or rare occasions. emphysema. For immunocompromised patients 400 mg 5 times daily for 5 days (longer if new lesions appear during treatment or if healing incomplete. pyodermas. Product Guide renal insufficiency. endemic goitre and Hashimoto’s thyroiditis). burns. blurred vision have been reported. Dosage & Administration: Treatment of initial herpes simplex: 200 mg 5 times daily usually for 5 days. Abrasions. glaucoma or urinary tract blockade should take Meclizine HCl (like other antiemetics) with caution. severe burns may produce systemic adverse Effects such as metabolic acidosis. secondarily infected dermatoses.216 in individuals who have shown a previous hypersensitivity to these ingredients. Thyroid disorders (in particular nodular colloid goitre. infected decubitus or stasis ulcers. 217 Side Effect: Skin rashes. heartburn. hypercalcemia. sour stomach and upset stomach. may be repeated hourly if needed or as directed by the physicians. 200 mg/5ml Suspension & 50 mg/gm Cream. Treatment of initial rectal (Proctitis) herpes infections: An oral Aciclovir dosage of 400 mg 5 times daily for 10 days or until clinical resolution occurs has been recommended. Side Effect: Generally well tolerated. Contraindication & Precaution: Hypersensitivity to any of the ingredients. Virux® cream is not recommended for application to mucous membrane such as eye. Children under 2 years : 200 mg 4 times daily Children 2-5 years : 400 mg 4 times daily Children Over 6 years : 800 mg 4 times daily Treatment of herpes zoster (Shingles): 800 mg 5 times daily for 7 days. Children under 2 years: Half of the adult dose. Because of the potential for serious adverse reactions to aciclovir in nursing infants. Treatment should continue for 5 days.Product Guide 200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months. Children : HSV infections in children over 2 years should be given adult doses and children below 2 years should be given half of the adult dose. Ketoconazole. Children over 2 years: Adult dose. Preparation: 200 mg & 400 mg Tablet. If healing does not occur. Use in Pregnancy & Lactation: Thought to be the safest antacid during pregnancy & lactation. mouth. Drug Interaction: Probenecid. Indication: Fast relief from hyperacidity and related symptoms like acid indigestion. Children under 2 years: Half of the adult dose. Children below 40 kg:20 mg / kg (maximum 800 mg) per dose orally 4 times daily (80 mg / kg/day) for 5 days. . Cream : Virux cream should be applied to lesions or impending lesions 5 times daily (at 4 hourly intervals omitting the nighttime dose). Or. nausea. Amphotericin B. X Xcid TM Active Ingredient: Calcium Carbonate BP 1000 mg chewable antacid tablet. Use in Pregnancy and Lactation: The drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.800 mg 4 times daily for 5 days. headache and abdominal pain. Contraindication & Precaution: Known to be hypersensitive to aciclovir. Prophylactic treatment of herpes simplex in the immunocompromised: 200 to 400 mg 4 times daily. vomiting. diarrhea. a decision should be made whether to discontinue nursing or the drug. Children over 2 years: Adult dose. Treatment of vericella (chicken pox): Adult and children over 40 kg . vagina etc. renal calculi and hypophosatemia. Dosage & Administration: 2-3 tablets when symptoms occurs. treatment may be extended for up to 10 days. the drug’s potential for causing chromosomal damage at high concentrations should be considered. Contraindication & Precaution: Hypersensitivity. dyspepsia. Product Guide Xfin® Active Ingredient: Terbinafine. Dosage & Administration: The recommended dosage is 600-900 mg Dexibuprofen per day. Drug Interaction: There is no known drug interaction with terbinafine cream. rheumatoid arthritis and ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID associated gastric ulcers.218 Preparation: Calcium Carbonate 1000 mg/Chewable antacid tablet. upper abdominal pain. at least 30 minutes before meal. itching or stinging. terbinafine cream should not be administered during pregnancy. Symptomatic treatment of mild to moderate pain and inflammation including dysmenorrhoea and dental pain. Use in Pregnancy and Lactation: Unless the potential benefits outweigh the potential risks. Use in Pregnancy & Lactation: Pregnancy category C. Indication: Fungal infections of the skin caused by candida dermatophytes. Contact with the eyes should be avoided. allergic reaction. Preparation: 1% Cream. gastric ulcer. diarrhea. mothers should not receive terbinafine whilst breast feeding. Use in Children: Use in children less than 18 years has not been established yet Preparation: Naproxen 375 mg + Esomeprazole 20 mg Tablet & Naproxen 500 mg + Esomeprazole 20 mg Tablet X Xflam TM Active Ingredient: Dexibuprofen Indication: Management of pain & inflammation associated with osteoarthritis and other musculoskeletal disorders. during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery. nausea etc. Dosage & Administration: Once or twice daily. urticaria. Late pregnancy. or other allergic-type reactions after taking aspirin or other NSAIDs. History of asthma. gastritis. Side Effect: Redness. Drug Interaction: Concomitant use of NSAIDs may reduce the antihypertensive Effect of ACE inhibitors. candida Pityriasis versicolor. Dosage & Administration: One Xenole 375 or Xenole 500 tablet twice daily. diuretics. Contraindication & Precaution: Known hypersensitivity. Xenole TM Active Ingredient: Esomeprazole Naproxen & Indication: For the relief of signs and symptoms of osteoarthritis. at 2-3 divided . and betablockers. Side Effect: Most common side Effects are erosive gastritis. confusion. Less common reactions Vomiting. and severe liver function impairment. 219 Indication: Nefopam is most commonly used to treat pain after surgery. Less common Side Effect: Flatulence. Dosage & Administration: Tablet: Adults:The usual starting dose is two tablets taken three times daily. Children Nefopam is not recommended for children under the age of 12 years. nervousness. Rarely a temporary harmless pink discolouration of the urine has occurred. who experience attack of asthma. Nefopam should not be used in the treatment of myocardial infarction. Maximum single dose is 400 mg. Contraindication & Precaution: Nefopam is contraindicated in patients with a history of convulsive disorders and should not be given to patients taking monoamine oxidase (MAO) inhibitors. headache. This may be increased up to a maximum of three tablets taken three times a day. Use in Pregnancy & Lactation: Nefopam is X Xripa® Active Ingredient: Hydrochloride. vomiting. rhinitis. urticaria. & abdominal pain. insomnia. Dexibuprofen should be used with cautions in nursing mothers. bronchospasm. fatigue. The dosage can be raised to adult dosage if well tolerated.tachycardia and aggravation of angina have been reported. drowsiness. pruritus. take it as soon as you remember. insomnia. Preparation: 300 mg & 400 mg Tablet. dental pain. If you miss a dose.Product Guide doses. in particular. sweating. It is strongly recommended that the starting dose does not exceed one tablet three times daily as the elderly appear more susceptible to. Contraindication & Precaution: Dexibuprofen is contraindicated in patients with previous history of hypersensitivity to Dexibuprofen or other NSAIDs. Elderly:Elderly patients may require reduced dosage due to slower metabolism. Dexibuprofen is contraindicated in patients. the CNS side Effects of nefopam and some cases of hallucination and confusion have been reported in this age group.Then carry on taking the tablets as recommended by your doctor.Nefopam should not be used to treat the pain from a heart attack.. urticaria or edema after use of similar drugs (e. blurred vision. dry mouth. It is also contraindicated in patients with active or suspected hemorrhage. bronchospasm. This advice is based on the lack of clinical experience for this indication. The dosage can be raised temporarily up to 1200 mg Dexibuprofen per day in patients with acute disorders or exacerbations. purpura. & tinnitus. Crohn’s disease or ulcerative colitis. hallucinations.g. kidney function impairment (GFR < 30ml/min). lightheadedness and urinary retention may occur. muscular pain and pain associated with cancer. Elderly patient: Lowest Effective dose is recommended. acute rhinitis. Side Effect: More common reactions Nausea. aspirin or other NSAIDs). Use in Children: Patients below 18 years of age have not been established. diarrhea. nausea. Use in Pregnancy & Lactation: Use of Dexibuprofen should be avoided during the pregnancy. Side Effect: Dyspepsia. patients with serious heart diseases. Nefopam . and headache. 220 not recommended for pregnant women or those likely to become pregnant unless the expected benefit to the mother outweighs any potential risk to the foetus. Product Guide gastric and duodenal ulcer. There is no evidence of adverse reactions in breast-fed infants of mothers taking Tenoxicam. in whom salicylates or other NSAIDs induce symptoms of asthma. dyspepsia. As known from other NSAIDs. headache. A decision should be made whether to discontinue nursing or discontinue the medication. but Tenoxicam attenuates the blood pressure lowering Effect of Hydrochlorothiazide. Use in Pregnancy & Lactation: Treatment during the third trimester of pregnancy should be avoided. Preparation: 30 mg Tablet. a daily dosage of 20 mg should be given at the same time of day. Side Effect: The following undesirable Effects have been reported in few cases: Gastrointestinal tract: gastric. rhinitis or urticaria. Use in Children: Not yet established Xten TM Active Ingredient: Tenoxicam. Nefopam is excreted in human milk. epigastric and abdominal discomfort. Central nervous system: dizziness. Tenoxicam might attenuate the antihypertensive Effects of alpha-adrenergic blockers and ACE-inhibitors. nausea. post-operative pain and acute gout. Contraindication & Precaution: Hypersensitivity to Tenoxicam or any component of the product or other non-steroidal anti-inflammatory drugs (NSAIDs). X . No interactions have been reported between Tenoxicam and centrally acting alpha agonists or calcium channel blockers. Drug Interaction: Tenoxicam may have the following drug interactions: Acetylsalicylate and Salicylates: Salicylates increase the clearance and volume of distribution of NSAIDs including Tenoxicam Anti-platelet agents and SSRIs: There is an increased risk of gastrointestinal bleeding when anti-platelet agents and selective serotonin-reuptake inhibitors (SSRIs) are combined with NSAIDs Diuretics and antihypertensives: No clinically significant interaction between Tenoxicam and Frusemide was noted. There was no clinically relevant interaction when Tenoxicam was administered together with Atenolol. For post-operative pain the recommended dose is 40 mg once daily up to five days and for acute attacks of gout the recommended dose is 40 mg once daily for two days followed by 20 mg once daily for a further five days. suffering from gastritis. The recommended dose for primary dysmenorrhoea is 20 to 40 mg once daily. Indication: • Rheumatoid arthritis • Osteoarthritis • Ankylosing spondylitis • Post-operative pain • Acute gout • Primary dysmenorrhoea Dosage & administration: For all indications except primary dysmenorrhoea. taking into account the potential for adverse Effects for the foetus and the importance of treatment to the mother. heartburn. diarrhoea. Night blindness & Mental disturbances. Adults and child over 30 kg : 10 ml (2 teaspoonful) 1-3 times daily. Drug Interaction: Concomitant intake of a tetracycline and zinc may decrease the absorption of both the tetracycline and zinc. Similarly concomitant administration of zinc and quinolone may also decrease the absorption of both. Parakeratatic skin lesions. if it causes stomach upset. Side Effect: Zinc may cause nausea. This medicine should be used regularly to get the most benefit from it. burns. A zinc supplement is given until clinical improvement occurs but it may need to be continued in severe malabsorption. this may be taken with a meal.Product Guide Preparation: 20 mg Tablet. Zesup Forte Syrup: Child under 10 kg : 5 ml (1 teaspoonful) 1 time daily. Zinc sulphate and Folic acid. Preparation: Zesup Syrup Each 5 ml contains Zinc Sulphate Monohydrate USP equivalent to 10 mg elemental Zinc. Zinc crosses the placenta and is present in breast milk. Acrodermatits enteropathica. This drug is most Effective if they are taken Z Zif ® Active Ingredient: Ferrous sulphate. However. Loss of appetite. Zinc Indication: Zesup and Zesup Forte are indicated in zinc deficiency and/or zinc losing conditions. Zesup® Active Ingredient: Monohydrate. Child between 10 . excessive loss of zinc can occur in trauma.30 kg : 10 ml (2 teaspoonful) 1-3 times daily. Impaired immunological response. Anaemia. Sulphate Contraindication & Precaution: It is contraindicated in those who are hypersensitive to any component of the ingredient of this zinc containing supplement.30 kg : 5 ml (1 teaspoonful) 1-3 times daily. so doses adjustment is needed. heartburn and gastritis. Deformed bone formation. Use in Pregnancy & Lactation: Zinc is used during pregnancy and lactation at a dose of 20 mg per day. Zinc deficiency can occur as a result of inadequate diet or malabsorption. Defective and delayed wound healing. vomiting. metabolic disease or in zinc losing states. 221 at least 1 hour before or 2 hour after meals. stomach upset. Severe growth retardation. Concomitant intake of penicillamine and zinc may depress absorption of zinc. diarrhoea and protein losing conditions. Dosage & Administration: Zesup Syrup: Child under 10 kg : 5 ml (1 teaspoonful) 2 times daily. Child between 10 . Zesup Forte Syrup: Each 5 ml contains Zinc Sulphate Monohydrate USP equivalent to 20 mg elemental Zinc. In acute renal failure zinc accumulation may occur. It is indicated in the following conditions Recurrent respiratory tract infections. Diarrhoea. Indication: Treatment and prophylaxis of . Adults and child over 30 kg : 20 ml (4 teaspoonful) 1-3 times daily. Preparation: Each TR capsule contains Elemental Iron 50 mg as Carbonyl Iron. Vitamin B-Complex.80 mg. Indication: Treatment and prophylaxis of Iron. Folic Acid: Phenobarbital. constipation and diarrhoea. diarrhoea may occur. Patients may complain of dark stool.50 mg and Zinc Sulphate Monohydrate 61. Dosage & Administration: 1 capsule daily. Folic Acid . levothyroxine. vomiting. Zif-CI ® Active Ingredient: Carbonyl Iron + Folic Acid + Zinc. Z Side Effect: Dark stools. allergic reactions.222 iron. levodopa. Thus administration of Iron during the first trimester requires definite evidence of Iron deficiency. Folic Acid 0. Preparation: Each timed release capsule contains dried Ferrous Sulphate 150 mg. discomfort. Drug Interaction: Tetracycline. Dosage & Administration: Adult : one capsule daily before food or as directed by the physician. folic acid and zinc deficiency specially during pregnancy and lactation. In patients with renal failure there may be the risk of Zinc accumulation. Care should be taken in haemochromatosis. antacids. nausea. phenytoin and primidone. Side Effect: Nausea.80 mg. methyldopa and penecillamine. It is also indicated for the geriatric patients ® . Foil acid 500 mcg and Zinc Sulphate Monohydrate 61. Indication: It is indicated for the treatment and prophylaxis of Iron. Use in Pregnancy: Should be avoided during first trimester of pregnancy. ContraindicatIon and Precaution: Hypersensitivity. Drug Interaction: Carbonyl Iron: Tetracycline antibiotics. penicillamine. Folic Acid. haemolytic anaemia or red cell aplasia. gastrointestinal irritation. anorexia.such as haemochromatosis. vomiting. quinolone antibiotics. anorexia. discomfort. 2 capsule may be required in more severe cases. Use in Pregnancy and Lactation: Use of any drug during the first trimester of pregnancy should be avoided if possible. Folic Acid and Zinc deficiency especially during pregnancy and lactation. Prophylaxis of Iron deficiency where inadequate diet calls for supplementary Zinc and Folic Acid is justified during the remainder of pregnancy. Product Guide should be taken in patient with Iron overload states. Vitamin B-Complex. haemolytic anaemia or red cell aplasia. Rarely allergic reactions. Contraindication & Precaution: Known hypersensitivity to any of its component or those with Iron overload. constipation. Vitamin C (as Ascorbic Acid) and Zinc Sulphate Monohydrate. Vitamin C and Zinc deficiency especially during pregnancy and lactation. Special care Zif Forte Active Ingredient: Carbonyl Iron. zinc accumulation could exist. Carbonyl Iron pellets incorporated into the capsules to reduce the possibility of gastrointestinal irritations. Contraindication & Precaution: It is contraindicated in patients with known hypersensitivity to any of its component or those with Iron overload. Vitamin C (as Ascorbic Acid) USP 50 mg and Zinc Sulphate Monohydrate USP 61. fever and respiratory distress. constipation and diarrhoea may occur. Indication: Prophylaxis and in the prevention of Zinc and Folic Acid deficiencies. anorexia. Special care should be taken in patients with Iron overload states.Failure to response to the treatment requires further investigations to exclude other causes of anaemia. Patients may complain of dark stool. quinolone antibiotics. Thus administration of Iron during the first trimester requires definite evidence of Iron deficiency. phenytoin and primidone are possibly reduced. Folic Acid interacts with antiepileptics. Rarely there may be allergic reactions. levodopa. dyspepsia. Dosage & Administration: One tablet daily or as recommended by the physician. discomfort. Prophylaxis of Iron deficiency where inadequate diet calls for supplementary Zinc and Folic acid is justified during the remainder of pregnancy. Use in Pregnancy Recommended. 223 Preparation: Each capsule contains Elemental Iron 50 mg (as Carbonyl Iron INN). In patients with renal failure there may be the risk of Zinc accumulation. Contraindication: Zinc in patients having hypersensitivity to Zinc. so plasma concentrations of phenobarbital. vomiting. Nicotinamide USP 10 mg. Zifolet® Active Ingredient: Folic Acid & Zinc. levothyroxine. and Lactation: Z Preparation: Each film coated tablet contains Folic Acid 5 mg & Zinc 20 mg). Thiamine Mononitrate USP 2 mg. Dosage & Administration: Adult: One Capsule daily before food or as directed by the physician. nausea. haemolytic anaemia or red blood cell aplasia. vomiting.80 mg. Side Effect: Abdominal pain. Drug Interaction: Large amount of Calcium decreases the absorption of Zinc.50 mg. Pyridoxine Hydrochloride BP 1 mg.such as haemochromatosis. Folic Acid BP 0. Ziliron® Active Ingredient: Iron (III) Hydroxide . Use in Pregnancy & Lactation: Use of any drug during first trimester of pregnancy should be avoided if possible.Product Guide with generalized weakness due to vitamins and minerals deficiency. Drug Interaction: Carbonyl Iron decreases the absorption of tetracycline antibiotics. Riboflavin USP 2 mg. methyldopa and penicillamine. Folic Acid in untreated cobalamine deficiency. Side Effect: Gastrointestinal irritations such as nausea. Product Guide Polymaltose Complex.Folic Acid BP. Folic Acid and Zinc Indication: Prevention and treatment of Iron. etc. Two capsules may be required a day in severe cases or as directed by the physician. Side Effect: Occasionally gastrointestinal irritation such as sensation of repletion.Vitamin B-complex & Zinc Sulphate Monohydrate. Preparation: Each capsule contains Iron (III) Hydroxide Polymaltose Complex INN 188 mg equivalent to elemental Iron 47 mg. Riboflavin BP 2 mg. Dosage & Administration: One capsule daily. Prophylaxis of Iron deficiency where inadequate diet calls for supplementary Zinc and Folic Acid is justified during the remainder of pregnancy. Two tablets may be required a day in severe cases or as recommended by the physician. nausea. Nicotinamide BP 20 mg & Zinc Sulphate Z Ziliron-B® Active Ingredient: Iron (III) Hydroxide . tannin. pressure in the epigastric region.50 mg elemental Zinc. Folic Acid and Zinc deficiencies. Drug Interaction: No interaction has been observed.5 mg. antacids) are unlikely to occur. oxalates. Since. Contraindication & Precaution: Contraindicated in patients with a known hypersensitivity to any of the ingredients of this product. Indication: For the prevention and treatment of Iron. Thus administration of Iron in the first trimester requires definite evidence of Iron deficiency. Contraindication and Precaution: In patients with a known hypersensitivity to any of the ingredients of this product. a dark coloration of the stool may occur which is without clinical significance. ionic interaction with foodstuff components (phytates. Very few allergic reaction may be seen.50 mg and Zinc Sulphate Monohydrate 61.224 Polymaltose Complex. As with all Iron preparations. Zinc & Vitamin B-Complex deficiencies.80 mg equivalent to 22. Dosage & Administration: One tablet daily. Folic Acid 0. Use in Pregnancy and Lactation: Use of any drug during the first trimester of pregnancy should be avoided if possible. Pyridoxine Hydrochloride BP 2 mg. Use in Pregnancy: Use of any drug during the first trimester of pregnancy should be avoided if possible. Preparation: Each film coated tablet contains Iron (III) Hydroxide Polymaltose Complex 188 mg equivalent to 47 mg elemental Iron. Thiamine Hydrochloride BP 5 mg.) and concomitant administrations of medicaments (tetracyclines. Folic Acid. constipation or diarrhoea may occur. Folic Acid BP 0. Thus administration of Iron during the first trimester requires definite evidence of Iron deficiency. Prophylaxis of Iron deficiency where inadequate diet calls for supplementary Zinc and Folic Acid is justified during the remainder of pregnancy.. Side Effect: Generally well tolerated. Drug Interaction: No interactions have been observed. Dark coloration of stool may occur which is without clinical significance. the Iron is complex bound. Use in Pregnancy and Lactation: The initial treatment of chlamydial cervicitis in pregnancy. Prolonged use may result in overgrowth of non-susceptible organisms. flatulence. sinusitis and pharyngitis/ tonsillitis. Patients are advised not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis. eight to twelve hours apart for the first two days and then instill 1 drop in the affected eye (s) once daily for the next five days. Exercise caution when administering to a nursing woman. Avoid concomitant administration with terfenadine or astemizole.Product Guide Monohydrate USP 61. reversible elevations in liver transaminases. discontinue use and institute alternative therapy. Contraindication & Precaution: Azithromycin ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredient in the formulation. skin and soft tissue infections. Precaution should be taken in patients with more severe renal impairment. Side Effect: Nausea. 200 mg/5 ml Suspension. Use in Children: Safety and efficacy in pediatric patients below 1 year have not been established. If super-infection occurs. 225 Zimax TM Eye Drops Zimax TM Active Ingredient: Azithromycin. sexually transmitted diseases. Ergot Derivatives. Side Effect: The most frequently reported ocular adverse reaction was eye irritation. occurred in approximately 1-2% of Active Ingredient: Azithromycin. azithromycin should be used only when clearly needed.80 mg. Z . Streptococcus pneumoniae. Contraindication & Precaution: Known hypersensitivity. diarrhoea. otitis media. Dosage and administration: Instill 1 drop in the affected eye (s) twice daily. Preparation: 500 mg Tablet. In other infections. Children: 10 mg/ kg body weight once daily for 3 days. Digoxin & Cyclosporin. dizziness and skin rashes. Antihistamines. Haemophilus influenza. should not be used in patients with hepatic disease. Staphylococcus aureus. vomiting. headache. Streptococcus mitis group. Use in Pregnancy and Lactation:USFDA Pregnancy Category B. Drug Interaction: Antacids. Dosage & Administration: Adults: 500 mg once daily for 3 days. including fungi. 250 mg Capsule. Indication: Zimax 1% Eye Drops is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following microorganisms: CDC coryneform group G. abdominal discomfort (pain/cramps). Caution should be exercised when Azithromycin ophthalmic solution is administered to a nursing woman. Indication: Bronchitis and pneumonia. dry eye. Product Guide concurrently with other highly plasmaprotein bound drugs. and sinusitis in less than 1% of patients. Side Effect: Abdominal pain.11 years : 10 ml (200 mg) twice daily for 3 days. Other adverse reactions were reported burning. Preparation: 500 mg Tablet. nasal congestion.3 years : 5 ml (100 mg) twice daily for 3 days. diarrhoea vomiting and headache have been reported rarely. Should be administrated with caution to patients with hepatic. Preparation: Zimax 1% Eye Drops: Each container contains 5 ml of Azithromycin 1% sterile solution. punctate keratitis. ocular discharge. stinging and irritation upon instillation. dysgeusia. renal and biliary disease. Dosage & Administration: Age 1 . Indication: Diarrhoea caused by Cryptosporidium parvum and Giardia lamblia. Nursing mother: Caution should be exercised when Nitazoxanide is administrated to a nursing woman. Age 4 . Contraindication & Precaution: Known hypersensitivity to Nitazoxanide or any other ingredient in the formulations. Drug Interaction: Caution should be u sed when administering Nitazoxanide Z . 30 ml & 60 ml Suspension (100 mg/5 ml). corneal erosion. Zox® Active Ingredient: Nitazoxanide. Age >12 years : 25 ml or 1 tablet (500 mg) twice daily for 3 days.226 patients. contact dermatitis. Amebiasis and helminth infections. Use in Pregnancy & Lactation: Pregnancy category B :This drug should be used during pregnancy only if clearly needed. Product Guide 227 SQUARE NATURAL MEDICINE . Children under 12 years of age: 1-2 teaspoonfuls (5 . Dosage & Administration: Adults: 3 teaspoonfuls (15 ml) 2 .10 ml) 2 . Indication: All kinds of cough. Dosage & Administration: Adults: 1 or 2 capsule to be taken 2 times daily with water. dry irritable cough. Emblica officinalis. Use in Pregnancy & Lactation: No adverse Effect of Amcivit syrup has been reported. Therefore. In acute cough. Termanalia chebula with some other herbs. Arubin® Active Ingredient: Ferrous fumarate. Indication: • Vitamin C deficiency • Scurvy • Anemia in children Dosage & Administration: Children under 12 years: 1 teaspoonful (5 Amlaki (Emblica .10 ml) 3 times a day. Side Effect: There is no known significant side Effect. It is also effective in throat irritation & hoarseness. Contraindication & Precaution: There is no evidence available on contraindication. Preparation: 100 ml syrup. Contraindication & Precaution: There is no evidence available on contraindication but it may happen in patients who are hypersensitive to any of its ingredients. Use in Pregnancy & Lactation: The safety of Adovas syrup in pregnancy has not been established. Precaution should be taken in patients who are hypersensitive to any of its ingredients. Preparation: 100 ml syrup. warm water can be added for better result. Indication: • Iron deficiency anemia • Anemia due to malnutrition • Loss of appetite It is the only herbal haematinic. Contraindication & Precaution: There is no evidence available on contraindication but it may happen in-patients who are hypersensitive to any of its ingredients.228 Product Guide ml) 2 times daily.3 times daily or as directed by the physician. Children: Not recommended under 12 years of age. which does not cause constipation like some other iron preparations due to the herbs used in it. Side Effect: No known side Effects.3 times a day. Caution should be taken with concomitant AmCivit® Active Ingredient: officinalis). it should be used during pregnancy only under the supervision of a physician. Adovas® Active Ingredient: Basak (Adhatoda Vasica) with some other herbs. allergic and smoker’s cough. Adult:1 .2 teaspoonfuls (5 . DM and others CNS stimulants. adequate iron intake is usually obtained from a proper diet. Children (8 years & above): 1 capsule 3 times daily or as directed by a physician.3 teaspoonfuls (10 . in the second and third trimesters. But caution should be taken in hypertension.15ml) 2 . with a little liquid. Use in Pregnancy & Lactation: In the first trimester of pregnancy. Adult: 2 . Use in Pregnancy & Lactation: No known restrictions. Problems in humans have not been documented with intake of normal daily recommended amounts. Some clinicians prefer to evaluate the patient before giving routine iron supplementation. It should not be taken with food or immediately after meals. . Contraindication & Precaution: There is no evidence available on contraindication. So iron supplements should not be taken within 1 hour before or 2 hours after ingestion of any of the above. however. It should be taken 30 to 60 minutes before meals. The dose may be increased to a maximum of 2 capsules 3 times daily or as directed by a physician. Capsules must not be chewed or crushed. Preparation: 500 mg Capsule. Side Effect: No known side effects according to Commission E. when iron deficiency is more prevalent because of greatly increased requirements. Enerton® Active Ingredient: Extracts of Sida cordifolia. Side Effect: When used within the Colmint TM Active Ingredient: Peppermint oil (Mentha piperita). iron supplements may be recommended. Indication: • Irritable bowel syndrome • Abdominal pain & spasm • Abdominal distersion /bloating Dosage & Administration: Adults: 1 capsule 3 times daily 30 to 60 minutes before meal with a glass of water. Must be swallowed whole. Side Effect: Arubin capsules are not known to have any side effects if taken as per prescribed dosage. calcium supplements and tannin containing herbal preparations.3 times daily or as directed by the physician. Indication: • General weakness • Strength and energy booster • Superb sports tonic • Tonic for asthmatic patients Dosage & Administration: Children: Under the age of 12 years: Not recommended. 229 Contraindication & Precaution: Contraindicated in patients with achlorhydria and also contraindicated for infants and small children due to the potential risk of spasm of the tongue or respiratory tract. Preparation: 187 mg (0.Product Guide use of antacid.2 ml) enteric coated licap. Contraindication & Precaution: Caution should be taken in schizophrenia or those already receiving epileptogenic drugs such as phenothiazines.230 recommended dosage range. Contraindication & Precaution: The drug should not be used by patients with liver and kidney diseases. Overdose may cause loose stool and abdominal pain. GLA. Eyebil TM Active Ingredient: Bilberry (Vaccinium myrtillus L). Eprim® Active Ingredient: Evening primrose oil (Oenothera biennis). elevated blood pressure. insomnia.4 mg Tablet. Preparation: 500 mg Capsule. Yohimbe may counteract the hypotensive effect of antihypertensive medications. resulting inadequate blood pressure control. Pregnancy & Lactation: No known restriction. nausea. Product Guide Eredex Indication: TM Active Ingredient: Yohimbe (Pausinystalia yohimbe). Preparation: 5. Drug Interaction: Theoretically. chronic inflammation of the sexual organs or prostate gland or with a history of gastric or duodenal ulcers. Use in Pregnancy & Lactation: It is not recommended during pregnancy. tremor. pregnant and lactating women should get 5% of their total daily caloric intake from EFAs. LA. mania and vomiting. Side Effect: Adverse Effects are rare at recommended dosages. Preparation: 200 ml syrup. so it is reasonable to assume that evening primrose oil should be taken while nursing. Indication: • Retinopathy (hypertensive and diabetic) • Night blindness • Cataracts • Macular degeneration . According to World Health Organization (WHO). tachycardia. Indication: • PMS symptoms • Dysmenorrhea • Cyclical mastalgia • Atopic dermatitis • Skin disorder Dosage & Administration: 1 or 2 capsules 2 to 3 times daily or as directed by the physician. exanthema. Side Effect: Anxiety states. Enerton is well tolerated. • Erectile dysfunction (Male impotence) • Loss of libido • Exhaustion Dosage & Administration: Adult: 1 tablet 3 times daily or as advised by the physician. It may potentiate pharmaceutical MAOinhibitors. and DGLA are important components of human breast milk. 231 or before elective surgery. minerals or herbal supplement. depression. dizziness and headache • Vertigo & tinnitus • Peripheral vascular diseases • Sexual dysfunction secondary to SSRI use • Acute cochlear deafness Dosage & Administration: Giloba 60 mg 1 or 2 capsules 2 to 3 times daily or as advised by the physician. Contraindication & Precaution: Ginseng can be taken with any other vitamin. Indication: • Cerebral insufficiency • Demential syndromes: memory deficit. Side Effect: Over Ginseng’s many years of use.e. warfarin. Drug Interaction: None known.12 months) mental Dosage & Administration: One Gintex capsule 1 or 2 times a day or as advised by the physician. No known contraindications according to the German E Commission and World Health Organization (WHO). Contraindication & Precaution: None known.Product Guide •Retinitis pigmentosa •Hemorrhagic retinopathy Dosage & Administration: 1 capsule should be taken 2-3 times daily or as per the instruction of physician. Anecdotal evidence suggests that excessive doses may mildly elevate blood pressure and/or cause hyper sexuality. Preparation: 60 mg Capsule. Over stimulation and insomnia have also been reported with Ginseng. Preparation: 160 mg Capsule. Side Effect: No side Effects following proper administration of designated therapeutic dosages. It is also contraindicated in bleeding disorders due to increase bleeding potential associated with chronic use (6 . Use in Pregnancy & Lactation: No known restriction. no serious side Effects or drug interactions have been reported. . poor concentration. heparin & aspirin. Use in Pregnancy & Lactation: There is no known restriction on the use of ginkgo in pregnancy and lactation. Contraindicated in patients with known risk factors for intracranial hemorrhage. Indication: • General weakness & tiredness • Infertility in men • Type 2 diabetes mellitus • Cognitive function and performance enhancement Giloba® Active Ingredient: Ginkgo biloba. Side Effect: None known. Gintex® Active Ingredient: Panax ginseng. Contraindication & Precaution: Ginkgo should always be used with caution in patients taking anticoagulants or antiplatelet agents i. yarrow (Achillea spp. intestinal obstruction. Product Guide Use in Pregnancy & Lactation: The Commission E found no known restrictions. Ispergul® Active Ingredient: Ispargula husk.) flower.5 gm (1 sachet) 2 to 3 times daily with a glass of water. Preparation: 400 mg Capsule.) flower. especially allergies to members of the family Asteraceae including arnica (Arnica spp. Contraindication & Precaution: Individuals with an increased tendency to have allergies. Drug Interaction: The Commission E stated that there are no known interactions. Dosage & Administration: 1 or 2 capsules 2 to 3 times daily or as advised by the physician. Urinary tract infection. Preparation: 500 mg Capsule. Patients with exocrine pancreatic insufficiency should avoid use of psyllium due to its inhibitory actions on pancreatic lipase. Hyperlipidemia. Side Effect: Incorrect administration procedure (with too little fluid) can cause the product to swell and lead to obstruction of the esophagus or intestine. Contraindication & Precaution: Psyllium is contraindicated in patients who have pathological narrowing in the GIT. Dosage & Administration: For adult: 3. ragweed (Ambrosia spp. difficulties in regulating diabetes mellitus. Drug Interaction: Concurrent use of licorice. fecal impaction. purpurea root. Carbamazepine bio-availability may reduce during concomitant administration of psyllium seed. Anaphylaxis has been reported with ingestion of an echinacea preparation made of E.).). Ulcerative colitis. marigold (Calendula officinalis L. particularly with older people. difficulty in swallowing or esophageal narrowing. chamomile (Matricaria spp. laxatives and antidiabetic agents may result in increased risk of hypokalemia and hypoglycemia. Inacea® Active Ingredient: Echinacea (Echinacea purpurea). Indication: Treatment and prevention of upper respiratory tract infections (URTls). Hemorrhoids. .5 gm (½ to 1 Sachet) 2 to 3 times daily with a glass of water. Children (6 to 12 year): 2 gm to 3. Side Effect: There are few reported adverse effects for internal and external applications. asters (Ast tataricus) and chrysanthemum (Chrysanthemum spp.) flower. Infection tendency. Indication: Constipation. Pyrrolizidine alkaloids (PAs) do not constitute a significant part of echinacea.) flower.232 Use in Pregnancy & Lactation: No known restriction according to the American Herbal Product Association & German Commission E. Immune deficiency. Seasonal Affective Disorder (SAD). For depression. Children: Not recommended for the children under 12 years. 233 Kamomil® Active Ingredient: Chamomile (Matricaria recutita). Preparation: 15 ml Oral Spray. (Hypericum perforatum). Jort® Active Ingredient: St. Contraindication & Precaution: Do not spray directly into the nose. the onset of response to St. . To prevent relapse. it produces few adverse side effects. Preparation: 3. Sage oil. Contraindication & Precaution: The Commission E Stated “None Known” . Side Effect: In patients with known allergy to anethole intolerance reactions may appear. John’s wort Indication: Depression. Anise oil. Livolite® Active Ingredient: Andrographis (Andrographis paniculata). Two puffs are equivalent to 1 fully effective single dose. Should not be administered in infants and children. Recent drug interaction reports suggest professional guidance when certain conventional pharmaceuticals may be simultaneously administered. John’s wort is generally very well tolerated. antidepressant should be continued at full therapeutic doses for at least 6 months after remission. Insomnia. Indication: • Inflammation of buccal and pharyngeal cavity • Periodontitis • Acute gingivitis • Pain after tooth extraction • Mucosal irritation caused by dental plates • Tonsillary angina • Canker sores • Bad breath Dosage & Administration: Adult: Inflamed areas in the mouth and pharynx to be sprayed 3 times daily.5 gm Sachet & 100 gm Container.Product Guide Use in Pregnancy & Lactation: No adverse Effects of Ispergul have been reported. Bergamot oil. requiring 2-4 weeks. Dosage & Administration: 1 Capsule 3 times daily. Side Effect: St. It is recommended to carry out the spray treatment after meals. Preparation: 300 mg Capsule. In general. Drug Interaction: None known. Obsessive Compulsive Disorder (OCD). Pine needle oil. Peppermint oil. or as long as 6 weeks. John’s wort is similar to that for conventional antidepressants. Use in Pregnancy & Lactation: No known restrictions. Eucalyptol and Methyl Salicylate. Product Guide daily after meal for 3 months. vomiting and loss of appetite. Side Effect: Large oral doses may cause gastric discomfort. Above 12 years and Adult:2 – 3 teaspoonfuls (10 . Drug Interaction: May have a synergistic effect with isoniazid. Preparation: 100 ml Syrup.5 ml) 2 .15 ml) 3 times daily after meal for 3 months. Indication: • Malnutrition • Immune deficiency . Contraindication & Precaution: Generally is well tolerated but caution should be taken in hyperthyroidism. Use in Pregnancy & Lactation: Women who are pregnant or nursing are advised to consult with a physician prior to use. Patients with medical conditions should talk to their doctors before taking Monera.5 years: 1/2 teaspoonful (2. Preparation: 200 mg Capsule. 6 – 12 years: 1 teaspoonful (5 ml) 2 – 3 times daily after meal for 3 months. It has also been shown to reduce the decline in cognitive function associated with phenytoin. •Attention Deficit Disorder (ADD) Attention Deficit Hyperactivity Disorder (ADHD) •Dementia •Alzheimer’s disease •Autistic Spectrum Disorder (ASD) Dosage & Administration: Children 2 .3 times Navit® Active Ingredient: Spirulina (Arthrospira platensis). Side Effect: No side effects in mentioned therapeutic doses. Drug Interaction: Bacopa may potentiate the activity of thyroid stimulating drugs or decrease the effects of anti-thyroid medications. flu • Common cold • Sinusitis • Viral hepatitis Dosage & Administration: 1 capsule 3 times daily between meals for 5 to 10 days or as directed by the physician. Although medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Indication: •Memory loss. an anti-seizure medication. Use in Pregnancy & Lactation: Andrographis should not be used during pregnancy or lactation. May work to decrease the toxicity of several drugs like morphine and other opiate drugs. fever and acute infection.234 Indication: • Viral fever. Contraindication & Precaution: Andrographis is contraindicated in cases of known allergy to plants of the acanthaceae family. Monera® Active Ingredient: Bacopa monnieri (Brammi) with some other ingredients as per BNAF. Ginger is contraindicated in people suffering from gallstones as it promotes the production of bile.10 ml) 2 to 3 times daily. Contraindication & Precaution: Spirulina is contraindicated in those who are hypersensitive to any component of a Spirulina-containing supplement. Contraindication & Precaution: There is no evidence available on contraindication . there are a few reports of allergic reactions to spirulina-containing supplements. Use in Pregnancy & Lactation: There is no known restriction on the use of Probiotics in pregnancy and lactation. Side Effect: No side Effects following proper administration of designated therapeutic dosages. Preparation: 500 mg Capsule. So Pepnor® should be taken carefully in obstructive jaundice. Use in Pregnancy & Lactation: Pepnor is a very good supplement for lactating mother & pregnant women. Indication: • Dyspepsia or indigestion • Abdominal gas or flatulence • Nausea. Bifidobacterium bifidum and fructo-oligosaccharides). Preparation: 4 billion probiotics in a Pepnor® Active Ingredient: Cuminum cyminum. Adult: 2 . Probio TM Active Ingredient: A Probiotic combination (Lactobacillus acidophilus. Lactobacillus bulgaricus. Side Effect: Occasional gastrointestinal symptoms. Side Effect: There is no known significant side effect.15 ml) 3 times daily or as directed by the physician.2 teaspoonfuls (5 . Use in Pregnancy & Lactation: Safe as per clinical study.3 teaspoonfuls (10 . have been reported.Product Guide 235 but it may happen in patients who are hypersensitive to any of its ingredients. Contraindication & Precaution: Not known. vomiting & anorexia • Abdominal colic Dosage & Administration: Children under 12 years: 1. • High Cholesterol • Allergic reaction • Skin disorders & hair loss • Decreased milk supply mothers in lactating Dosage & Administration: 4 to 6 Capsules (500 mg each) per day or as per the instruction of an appropriate health care provider. Also. Indication: • Diarrhea • Lactose intolerance • Vaginal infection • Antibiotic related illness Dosage & Administration: 1 or 2 capsules 3 times before meal or as directed by the physician. such as nausea. Preparation: 100 ml Syrup. Preparation: 70 & 140 mg Capsules.236 Capsule. Side Effect: A mild laxative Effect has occasionally been observed. it should only be used under the supervision of a physician. Indication: Acute viral hepatitis. .The capsules should be taken whole with some liquid. Alcohol related liver disease including cirrhosis. as a maintenance dose. Therefore. phalloides. Poisoning by A. Toxic hepatitis produced by psychotropic agents. 1 capsule 2 times daily is sufficient or advised by the physician depending up on the severity. Use in Pregnancy & Lactation: No information is available about the use of Silymarin in pregnancy and lactation. Toxic liver damage for supportive treatment in patients with jaundice. Product Guide Silybin® Active Ingredient: Silymarin (Silybum marinium). Contraindication & Precaution: There is no available information about contraindication. Dosage & Administration: 1 capsule should be taken 3 times daily. Abacavir + Lamivudine + Zidovudine Aceclofenac Aciclovir Adapalene Adapalene + Benzoyl Peroxide Adefovir Dipivoxil Albendazole Alfuzosin HCl Allopurinol Allylestrenol Alprazolam Ambroxol Amitryptyline HCl Amlexanox Amlodipine Amlodipine + Atenolol Amlodipine + Atorvastatin Amlodipine + Benazepril Amlodipine + Olmesartan Amlodipine + Valsartan Amoxicillin Amoxicillin + Clavulanic Acid Antacid Antacid + Simethicone Artemether + Lumefantrine Aspirin Atenolol Atenolol + Chlorthalidone Atorvastatin Azelastine Azithromycin 201 88 216 91 91 19 6 212 79 100 147 7 210 20 37 38 39 38 7 40 134 134 75 75 121 42 42 42 20 190 225 . C + Vit.Baclofen Beclometasone Beclomethasone Benzathine Penicillin Benzocaine Beta Carotene + Vit. E Betahistine Betamethasone Betamethasone + Neomycin Betamethasone Dipropionate + Clotrimazole Bisoprolol Fumarate Bisoprolol Fumarate + Hydrochlorothiazide Brimonidine Tartrate Bromazepam Bromfenac Bromhexine HCl Bromocriptine Budesonide + Formoterol Bupivacaine HCl + Dextrose Butamirate Citrate Butenafine Calcipotriol Calcipotriol + Betamethasone Dipropionate Calcitriol Calcium Calcium + Vitamin D + Magnesium + Manganese + Copper + Boron + Zinc Calcium + Vitamin-D Calcium Carbonate Calcium Carbonate Calcium lactate gluconate + Calcium carbonate + Ascorbic acid 88 24 25 25 154 175 128 67 26 154 27 28 118 114 150 135 29 30 12 132 32 70 71 36 33 36 34 35 217 33 . Calcium lactate gluconate + Calcium carbonate + Ascorbic acid + Vitamin D 34 40 15 41 222 222 69 69 118 124 45 123 92 213 196 46 45 115 6 192 99 19 47 77 48 48 49. 50 172 51 52 53 Capsicin Carbamazepine Carbimazole Carbonyl Iron + Folic Acid + Vitamin B Complex + Vitamin C + Zinc Carbonyl Iron + Folic Acid + Zinc Carvedilol Carvedilol Phosphate Cefaclor Cefepime Cefixime Cefotaxime Cefpirome Cefpodoxime Proxetil Ceftazidime Ceftriaxone Cefuroxime Cephradine Cetirizine Chloramphenicol Chlorhexidine Gluconate Chlorpheniramine Cilostazol Cinchocaine + Hydrocortisone + Framycetin + Esculin Cinnarizine Cinnarizine + Dimenhydrinate Ciprofloxacin Clarithromycin Clindamycin Clindamycin + Tretinoin Clobazam . Clobetasol Propionate Clobetasol Propionate + Neomycin Sulphate + Nystatin Clobetasone Butyrate Clonazepam Clopidogrel Clopidogrel + Aspirin Clotrimazole Cod Liver Oil Desloratadine Dexamethasone Dexamethasone + Chloramphenicol Dexibuprofen Dexketoprofen Dextran 70 + Hypromellose Dextromethorphan Dextromethorphan + Pseudoephedrine + Triprolidine Diazepam Diclofenac Diclofenac Potassium Diclofenac Sodium + Misoprostol Dicycloverine HCl Diflorasone Diacetate Diltiazem Diosmin + Hesperidin Diphenhydramine Diphenhydramine HCl + Zinc Acetate Domperidone Donepezil Doxycycline Dried Ferrous Sulphate + Folic acid + Thiamine Mononitrate + Riboflavin + Nicotinamide + Pyridoxine Hydrochloride + Ascorbic Acid 61. 63 62 82 76 11 12 4 152 186 63. 64 65 218 111 120 29 151 186 53 110 131 56 72 67 103 3 202 133 74 68 188 . 79 157 143 83 159 204 83 23 117 84 221 84 85 167 164 89 90 166 127 89.Drotaverine HCl Duloxetine Ebastine Econazole Nitrate + Triamcinolone Acetonide Efavirenz Enalapril Enoxaparin Entecavir Eperisone HCl Erythromycin Escitalopram Esomeprazole Estriol Etodolac Etoricoxib Ezetimibe Famotidine Febuxostat Fenofibrate Ferrous Fumarate + Folic Acid Ferrous Sulphate + Folic Acid + Zinc Fexofenadine Fexofenadine HCl + Pseudoephedrine HCl Finasteride Flucloxacillin Fluconazole Flunarizine Fluoxetine Flupenthixol + Melitracen Fluticasone propionate Folic Acid + Zinc 81 66 197 163 2 214 54 43 136 78. 200 223 . 98 66 57 185 100 58 139 138 211 101 161 202 60 174 173 18 106. 107 27 224 223 59 136 80 108 .Furosemide Furosemide + Spironolactone Gabapentin Gemfibrozil Gemifloxacin Gentamicin Glibenclamide Gliclazide Glimepiride Glimepiride + Rosiglitazone Glucosamine + Chondroitin Glycerol+Liquid Sugar Granisetron Guaiphenesin + Pseudoephedrine + Triprolidine Halobetasol Propionate Haloperidol Hydrocortisone Acetate Imipramine Indapamide Indapamide + Perindopril Erbumine Insulin Human (rDNA) Ipratropium Bromide Iron (III) Hydroxide Polymaltose complex + Vitamin B-Complex + Zinc Iron (III) Hydroxide Polymaltose Complex + Folic Acid + Thiamine Hydrochloride + Riboflavin + Pyridoxine Hydrochloride + Zinc Iron as Iron (III) hydroxide polymaltose complex + Folic acid + Zinc Iron Sucrose Injection Iron + Folic Acid + Vitamin A + Vitamin C + Zinc Isosorbide Mononitrate Itraconazole 94 95 96 60 82 97. Ivabradine Ketoconazole Ketoprofen Ketorolac Tromethamine Ketotifen Lacidipine Lactulose Lamivudine Lamivudine + Zidovudine Lansoprazole Lansoprazole + Clarithromycin + Amoxicillin Letrozole Levocarnitine Levocetirizine Levofloxacin Levofloxacin Hemihydrate Levonorgestrel Levosalbutamol Levothyroxine Sodium Lomefloxacin Loperamide HCl Loratadine Loratadine + Pseudoephedrine Sulfate Losartan Losartan + Hydrochlorothiazide Magaldrate + Simethicone Mebendazole Mebeverine HCl Meclizine HCl + Pyridoxine HCl Mecobalamin Melatonin 109 111 113 203 5 114 155 103 22 114 169 115 116 169 206 206 148 116 198 130 104 119 120 13 14 122 78 130 215 129 86 . 136 87 23 171 137 191 218 219 139 140 138 139 214 145 145 .Meloxicam Meropenem Metformin Methyl Salicylate + Menthol Metronidazole Metronidazole + Neomycin Sulphate + Polymyxin B Sulphate + Nystatin Miconazole Miconazole nitrate Miconazole Nitrate + Hydrocortisone Midazolam Misoprostol Mometasone Furoate Montelukast Moxifloxacin Multivitamin and Multimineral Multivitamin with Cod Liver Oil Mupirocin Nalbuphine Nalidixic Acid Naproxen Naproxen + Esomeprazole Nefopam HCl Nelfinavir Neomycin + Polymyxin B + Pramoxine HCl Neomycin Sulphate + Bacitracin Zinc Neomycin Sulphate + Bacitracin Zinc + Polymyxine B Sulphate Neostigmine Methyl Sulphate Nifedipine Nifedipine + Atenolol 126 192 56 160 8. 10 101 96 93 94 69 107 128 132 110 86. 117. 87. 171 127 181 40 180 61 152 153 4 182 151 179 21 16 158 147 209 1 1 2 157 158 32 182 76 161 112 204 205 .Nimodipine Nitazoxanide Nitroglycerin Norethisterone Nortriptyline + Fluphenazine Nystatin Ofloxacin Olanzapine Olmesartan Medoxomil Olmesartan Medoxomil + Hydrochlorothiazide Olopatadine Omeprazole Ondansetron Ornidazole Oseltamivir Oxazepam Oxiconazole Oxymetazoline Pantoprazole Paracetamol Paracetamol + Caffeine Paracetamol + Tramadol Paroxetine Pentoxifylline Perindopril Erbumine Permethrin Phenobarbital Phenoxymethyl Penicillin Phytomenadione Pioglitazone Pioglitazone + Glimepiride 146 226 17. 200 184 31 88 190 189 188 155 156 .Pioglitazone + Metformin HCl Piracetam Pivmecillinam Pizotifen Malate Povidone Iodine Prasugrel Prednisolone Pregabalin Prochlorperazine Mesilate Procyclidine Rabeprazole Sodium Ramipril Ramipril + Hydrochlorthiazide Ranitidine HCl Risedronate Sodium Ropinirole Rosiglitazone + Metformin HCl Rosuvastatin Salbutamol Salbutamol + Ipratropium Bromide Salbutamol Sulphate Salmeterol Salmeterol + Fluticasone Secnidazole Silver Sulfadiazine Simethicone Simvastatin Sitagliptin Sitagliptin+Metformin Sodium Alendronate Sodium Alendronate + Vit D3 176 142 75 131 216 73 104 142 166 162 169 177 178 140 178 162 187 180 195. 196 194 195 181 199. Potassium Chloride. Tri-Sodium Citrate Dihydrate & Processed Rice Powder Pharma Grade Sodium Cromoglicate Sodium Cromoglicate + Xylometazoline Sodium Dichloroisocyanurate Sodium Valproate Sparfloxacin Strontium Ranelate Sulfadoxine + Pyrimethamine Sulphamethoxazole + Trimethoprim Tacrolimus Tamsulosin HCl Tapentadol Tegaserod Hydrogen Maleate Tenofovir Disoproxil Fumarate Tenoxicam Terbinafine Tetracycline HCl Theophylline Thiamine Thiopental Sodium Tibolone Tiemonium Methylsulphate Tiotropium Bromide Tolterodine Tartrate Topiramate Tramadol Tranexamic acid Tretinoin Triamcinolone Acetonide 190 177 137 19 163 212 180 193 122 58 172 126 160 197 167 220 218 198 58 25 98 173 150 149 211 164 11 92 146 208 .Sodium Chloride Sodium Chloride. Trimebutine Maleate Trimetazidine HCl Urea Valaciclovir Vitamin B Complex + Zinc Vitamin B1+ Vitamin B6 + Vitamin B12 Vitamin B-Complex Vitamin C Vitamin C + Vitamin E + Zinc + Copper + Lutein Vitamin E Xylometazoline Zinc Oxide Zinc Sulphate Zinc Sulphate Monohydrate Zolmitriptan 201 14 77 174 26 141 23 44. 45 82 81 18 61 221 193 148 .