MScChemistrySyllabusCSSPG2010Affiliatedcolleges

UNIVERSITY OF CALICUT (Abstract) MSc programme in Chemistry under Credit Semester System (PG)Scheme and Syllabus -approved –implemented-with effect from 2010 admission - Orders issued. _________________________________________________________________________ GENERAL & ACADEMIC BRANCH-IV ‘J’ SECTION No. GA IV/J2/ 4684/10 Dated, Calicut University PO, 30.07.2010. Read:1. U.O.No. GAIV/J1/1373/08 dated, 23.07.2010. 2. Item no.2 of the minutes of the meeting of the Board of Studies in Chemistry held on 21.06.2010 ORDER As per University Order read as first, Credit Semester System was implemented to PG programmes in affiliated Arts and Science Colleges and Self Financing Centres of the University with effect from 2010 admission onwards. The Board of Studies in Chemistry ,vide paper read as second,considered the number of courses to be offered ,course content,evaluation and grading,etc of the MSc. Chemistry programme of affiliated colleges under CSS pattern to be implemented from the academic year 2010-11. The recommendations of the Board in respect of courses to be offered for M.Sc Chemistry under CSS and the syllabus were also finalized. The Vice Chancellor has approved the minutes subject to ratification by the Academic Council. Sanction has therefore been accorded for implementing the scheme and Syllabus of Ist Semester of MSc programme in Chemistry with effect from 2010 admission. Orders are issued accordingly. Scheme and Syllabus appended. Sd/DEPUTY REGISTRAR (G & A-IV) For REGISTRAR To The Principals of affiliated Colleges offering MSc programme in Chemistry Copy to: PS to VC,PA to Registrar,Chairman,B/S Chemistry,CE,EX,DRIII,DR,PG,EGI,Enquiry,System Administrator with a request to upload in the University website,Information Centes,GAI`F``G` GAII,III Forwarded/By Order Sd/SECTION OFFICER UNIVERSITY OF CALICUT (Abstract) M.Sc programme in Chemistry under Credit Semester System (PG)Scheme and Syllabus –II, III, & IV semesters-approved –implementedwith effect from 2010 admissions-Orders issued. _________________________________________________________________________ GENERAL & ACADEMIC BRANCH-IV ‘J’ SECTION No. GA IV/J2/4684/10 Calicut University PO, Dated.19.01.2011 Read:1. U.O.No. GAIV/J1/1373/08 dated, 23.07.2010. 2. U.O. No. GAIV/J2/4684/08 dated, 30.07.2010. 3. Minutes of the meeting of the Board of Studies in Chemistry held on 20.12.2010. 4. Orders of the Vice-Chancellor on 18.01.2011 ORDER As per University Order read as first, Credit Semester System was implemented to all PG programmes in affiliated Arts and Science Colleges and Self Financing Centres of the University with effect from 2010 admission onwards. The scheme and syllabus for the 1st semester of M.Sc Programme in Chemistry under CSS PG was implemented vide paper read as second above. The Board of Studies in Chemistry PG vide paper read as third above, finalized the syllabus of M.Sc. Chemistry programme under CSS PG for the II, III, & IV semesters. The Vice-Chancellor exercising the power of the Academic Council approved the minutes subject to ratification by the Academic Council vide paper read as 4 above. Sanction has therefore been accorded for implementing the scheme and Syllabus for the II, III, & IV Semester of M.Sc programme in Chemistry under CSS PG 2010 with effect from 2010 admission. Orders are issued accordingly. Scheme and Syllabus appended. Sd/DEPUTY REGISTRAR (G & A-IV) For REGISTRAR The Principals of affiliated Colleges offering MSc programme in Chemistry Copy to: PS to VC,PA to Registrar,Chairman,B/S Chemistry PG,CE,EX,DRIII,DR,PG,EGI,Enquiry,System Administrator (with a request to upload in the University website),Information Centres,GAI`F``G`, GAII,III/SF/FC/DF To Forwarded/By Order Sd/SECTION OFFICER 2 UNIVERSITY OF CALICUT M.Sc. CHEMISTRY (CSS PATTERN) Regulations and Syllabus with effect from 2010 admission Preamble The Board of Studies in Chemistry (PG) at its meeting held on 21.06.2010 considered the introduction of Credit Semester System (CSS) in affiliated colleges for the PG programmes in Chemistry and resolved to implement the CSS pattern from 2010 admission onwards. The revised course pattern, syllabus, distribution of credits and scheme of evaluation, etc. approved by the Board are given below: Course Pattern (a) (b) (c) (d) The name of the course shall be M.Sc. Chemistry under CSS pattern. The course shall be offered in four semesters within a period of two academic years. Eligibility for admission will be as per the rules laid down by the University from time to time. Details of the courses offered for the programme are given in Table I. The course shall be conducted in accordance with the course pattern, scheme of examination and syllabus prescribed. Of the 25 hours per week, 12 hours shall be allotted for theory, 12 hours for practicals and 1 hour for seminar. Theory Papers In each semester there will be three theory papers. All the theory papers in the first and second semesters are core papers. In the third semester there will be two core theory papers and one elective paper. Colleges can choose any one of the elective papers given in table 1. In the fourth semester there will be one core paper and two elective papers. College can choose any two elective papers from those given in table 1. However a candidate may be permitted to choose any other elective papers without giving any lecture classes. Practicals: In each semester there will be three core practical papers (2 credits each). However practical examination will be conducted only at the end of the second semester for CHPO1, CHPO2, CHPO3 and at the end of fourth semester for CHPO4, CHPO5, CHPO6. Project and Viva Voce: Each student will have to do an independent research project work during the entire course under the guidance of a faculty member of the college/ scientists of recognized research institutions and submit the dissertation at the end of the fourth semester for evaluation (5 credits). There will be a comprehensive viva voce (3 credits) at the end of the fourth semester. The viva voce will be based on the theory and practical papers and the project work. 3 Dr. K. Krishnankutty Chairman BOS in Chemistry (PG) 4 TABLE I Courses offered for M.Sc. Chemistry Programme under CCSS in Affiliated Colleges Course Code CH1CO1 SEMESTER I CH1CO2 CH1CO3 CH1PO1 CH1PO2 CH1PO3 CH2CO4 SEMESTER II CH2CO5 CH2CO6 CH2PO1 CH2PO2 CH2PO3 CH3CO7 CH3CO8 SEMESTER III CH3PO4 CH3PO5 CH3PO6 CH3EO1 CH3EO2 CH3EO3 Course Title Theoretical Chemistry I Inorganic Chemistry I Organic Chemistry I Inorganic Chemistry Practical I Organic Chemistry Practical I Physical Chemistry Practical I Total Credits (Core) Theoretical Chemistry II Physical Chemistry I Organic Chemistry II Inorganic Practical I Organic Practical I Physical Practical I Total Credits (Core) Physical Chemistry II Inorganic Chemistry II Inorganic Practicals II Organic Practicals II Physical Practicals II Synthetic Organic Chemistry Natural Products Polymer Chemistry Total Credits – Core Elective 4 4 4 4 4 4 4 4 4 4 4 8 4 4 4 4 4 4 4 Instruction / Week 4 4 4 4 4 4 12 4 4 4 4 4 4 24 4 4 Credits 4 4 4 5 CH4CO9 CH4PO4 CH4PO5 SEMESTER IV CH4PO6 CH4EO4 CH4EO5 CH4EO6 CH4EO7 CH4EO8 CH4PrO1 Advanced Topics in Chemistry Inorganic Chemistry Practical II Organic Chemistry Practical II Physical Chemistry Practical II Instrumental Methods of Analysis Computational Chemistry Material Science Industrial Catalysis Bioinorganic and Organometallic Chemistry Research Project and Viva Voce Total Credits Core Elective Project 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5+3=8 16 8 8 TOTAL CREDITS OF THE PROGRAMME CORE ELECTIVE PROJECT AND VIVA VOCE Total Credits 60 12 8 80 6 . important features of the problem. quantum mechanical operators corresponding to angular momenta ((Lx. linear and nonlinear operators. Quantization of angular momentum. well behaved functions. Potential energy of hydrogen-like systems. Operator postulate. Laguerre and associated Laguerre polynomials. recursion relation. eigen functions and eigen values of an operator.UNIVERSITY OF CALICUT M. Rigid rotator (complete treatment): The wave equation in spherical polar coordinates. separation of variables. the Phiequation and the Theta-equation and their solutions. handling of imaginary wave functions. CHEMISTRY CSS PATTERN – SEMESTER I CH1CO1 – THEORETICAL CHEMISTRY – I (4 Credits) (72 h) UNIT I : The Foundations of Quantum Mechanics (9 h). UNIT IV : Quantum Mechanics of Hydrogen-like Atoms (9h). the wave equation in spherical polar coordinates. orthonormality of wave functions. Lx'. operator algebra. the R. space quantization. Hermitian operators and their properties. Lx). Ladder operator method for angular momentum. important features of the problem. Non-planar rigid rotor (or particle on a sphere). Rodrigue's formula. polar diagrams of spherical harmonics. UNIT III : Quantum mechanics of Rotational motion (9 h). Laplacian operator. spherical harmonics (imaginary and real forms). commutation relations between these operators.Cartesian. cylindrical polar and spherical polar coordinates and their relationships. wave functions and energies of hydrogen-like atoms. conservative systems and time-independent Schrödinger equation. eigen value equation. Particle in a one-dimensional box with infinite potential walls. Free particle in one-dimension. Dirac's relativistic equation for hydrogen 7 . One-dimensional harmonic oscillator (complete treatment):. wave functions and energies. Expectation value postulate. planar rigid rotor (or particle on a ring). radial functions and radial distribution functions and their plots. Legendre and associated Legendre polynomials. Historical background of quantum mechanics. Detailed discussion of postulates of quantum mechanics – State function or wave function postulate. angular functions (spherical harmonics) and their plots. solution of the Phi-equation. harmonic oscillator model and molecular vibrations. The postulate of spin by Uhlenbeck and Goudsmith. Born interpretation of the wave function.Method of power series. wave functions in the real form. Eigen value postulate. separation of variables. Co-ordinate systems:. orbitals. Postulate of timedependent Schrödinger equation of motion. separation of variables. spherical harmonics as eigen functions of angular momentum operators Lx & Lx.Sc. Particle in a one-dimensional box with finite potential walls (or particle in a rectangular well) – tunneling. Theta and Phi equations and their solutions. Particle in a three dimensional box. Legendre and associated Legendre equations. eigen functions of commuting operators. UNIT II : Quantum mechanics of translational & vibrational motions (9 h). Hermite equation and Hermite polynomials. degeneracy. the Phi-equation. Oxford University Press. 5. Pearson Education. calculation of free valence. Schrödinger equation for a molecule.A. 2009. Viva books. Roothan's concept of basis functions – Slater type orbitals (STO) and Gaussian type orbitals (GTO). Semi empirical MO treatment of planar conjugated molecules – Hückel Molecular Orbital (HMO) theory of ethylene. A.L. 7. charge distributions and bond orders from the coefficients of HMO. symmetric and antisymmetric wave functions. P. Quantum Chemistry & Spectroscopy. 1968. Atkins and R. Hartree Self-Consistent Field method for atoms. I. bond order. perturbation treatment of the ground state of the helium atom. Pauli's antisymmetry principle. sp2 & sp3 hybridisation. Thomas Engel. variation treatment for the ground state of helium atom.N. 4.. UNIT VI : Quantum mechanics of many-electron atoms (9 h). Elementary Quantum Chemistry.S. Hartree-Fock SelfConsistent Field (HF-SCF) method for atoms. Hybridization – quantum mechanical treatment of sp.N. Pearson Education Inc. Quantum Mechanics in Chemistry. F.W.W. 2005. Comparison of MO and VB theories. correlation diagrams. Spin orbitals for many electron atoms.. Frost-Hückel circle mnemonic device for cyclic polyenes. Variation method – variation theorem with proof. Slater determinants. 8 . 2nd Edition. N2. C2. CO. 3. Student Solutions Manual for Quantum Chemistry 6th Edition. UNIT VIII : Chemical Bonding in polyatomic molecules (9 h). Born – Oppenheimer approximation. 2006. University Science Books. 1983 (first Indian edition. Pilar. construction of spin orbitals from orbitals and spin functions. Pearson Education Inc. McGraw-Hill. illustration of variation theorem using a trial function [e. Be2. Friedman. Perturbation method – time-independent perturbation method (nondegenerate case only). M. spin orbitals. illustration by application to particle in a ID-box with slanted bottom. Manybody problem and the need of approximation methods. 2009. Benjamin Inc. formula for the roots of the Hückel determinantal equation. Valence Bond (VB) theory – VB theory of H2 molecule. UNIT V : Approximation methods in quantum mechanics (9 h).. Independent particle model. singlet and triplet state functions (spin orbitals) of H2. Molecular Quantum Mechanics. I. MO treatment of homonuclear diatomic molecules – Li2. W. 6. References 1. Spectroscopic term symbols for diatomic molecules. UNIT VII : Chemical bonding in diatomic molecule (9 h). HMO theory of aromatic hydrocarbons (benzene). McQuarrie. noncrossing rule. MO theory of H2 molecule. Quantum Chemistry. Levine. 2. 4th Edition. butadiene & allylic anion. 2003). 6th Edition. Quantum Chemistry. x (a-x)] for particle in a 1D-box and using the trial function e-ar for the hydrogen atom..atom and discovery of spin (qualitative treatment). Levine. Hartree-Fock equations (derivation not required) & the Fock operator. Molecular Orbital (MO) theory – MO theory of H2+ ion. NO & HF.g. Hanna. Donald. 1969. O2 & F2 and hetero nuclear diatomic molecules – LiH. Quantum Chemistry. 1998. Vishal Publications. 2006. 1993.K. Flurry. 12. Academic Press Inc.. Lectures on Chemical Bonding and Quantum Chemistry. 9 . 1984. 4th Edition. Prism Books Pvt. Horia Metiu. 2nd Edition. 3rd Edition. L. Quantum Chemistry.L. Chandra. Datta. 14. 2003. 9. R. Lowe. McGrawHill. Prasad. 11. Tata McGraw-Hill. 2006. A. Cambridge University Press. 1994.K. M. R.. Jr.N. Prentice Hall. 13.8.S. C. An Introduction to Theoretical Chemistry. 1983. Pathania. New Age International. Quantum Chemistry. Physical Chemistry – Quantum Mechanics. Jack Simons. Quantum Chemistry and Spectroscopy (Problems & Solutions).P. J. 1935 (A good source book for many derivations). 10. Introduction to Quantum Chemistry. Ltd. Taylor & Francis. Introduction to Quantum Mechanics. 16.. Wilson. Pauling and E.B. 15. Phosphazene.Sc. factors influencing stability. UNIT V (9 h). UNIT II (9 h). Solid and molten acids in industrial processes. complexometric and luminescent indicators. MO diagram of complexes with and without pi-bonding. significant figures. UNIT III (9 h).and linear phosphazenes. cyclo. styx numbers. structure and applications. spectrochemical and nephelauxetic series. CHEMISTRY CSS SYSTEM – SEMESTER I CH1CO2 – INORGANIC CHEMISTRY – I . UNIT IV (9 h). orbital splitting in octahedral. Q test. Factors governing acid strength. Sulphur-nitrogen ring and chain compounds – synthesis. Co-precipitation. UNIT VII (9 h). Silicones – Synthesis. structure and application. Heterogeneous acid-base reactions – surface acidity. UNIT VII (9 h). Method of least squares. Hydroborate anions. Formation constants. Phosphorus-nitrogen compounds. Carbides and silicides. absorption. Phosphorus-sulphur compounds. reactions. Washing of the precipitate. UNIT VI (9 h). Factors affecting crystal field splitting.UNIVERSITY OF CALICUT M. methods of determination of stability constants. Borazines and Borides. super acids. MO theory – composition of ligand group orbitals. Boron hydrides. accuracy and precision. Principles of gravimetric analysis. statistical treatment of data. ignition of the precipitate. structure and bonding. Latimer and Frost diagram. classification and minimization of errors. limitations of analytical methods. Metalloboranes. Valence bond theory and its limitations. Acid-base. standard deviation. Titrations in non-aqueous solvents. Errors and treatment of analytical data. References 10 . Isopoly and heteropoly anions of early transition metals. students tests. Acid base theories – strength of acids and bases. H2SO4 and HF. solvent leveling. stabilization of unusual oxidation states. Polyhedral anions. Pourbaux diagrams. SO2. Wade's rule. Chelate-macrocyclic and template effects.4 CREDIT (72 h) UNIT I : (9 h). Metallic corrosion and passivity. The forbitals and f-block complexes. ambidentate and macrocyclic ligands. Boron cluster compounds. Introduction to co-ordination Chemistry – Stereochemistry of coordination compounds. Organoboranes and hydroboration. Fractional precipitation. Carboranes. tetrahedral and square planar fields. Complex formation titrations. effect of hard and soft acids and bases. The crystal field and ligand field theories. Theory Indicators. Organic precipitants. Standard reduction potentials and their diagrammatic representations Ellingham diagram. Precipitation from homogeneous solution. Formation and properties of precipitates. structure. Jahn-Teller effect. confidence limit. chemistry of non aqueous solvents – liquid NH3. Silicates and aluminosilicates – framework of silicates. redox. Racah parameters. bonding and uses. Electron deficient compounds – synthesis. A. Chand and Company Reprint 2009. Huheey.F. Blair. Tuli. 5.A.C. John Wiley and Sons. D. Alexander. McDanials and J. Cluster molecules of p-block elements. Azaroff. 8. 11 . e. 5th Edition. J. Inorganic Chemistry. 13.H. NY. Lindoy. Wahid U Malik. 1989. Structure and Reactivity. Selected Topics in Inorganic Chemistry. Douglous.H. 11.V. J. Mendham and R. Keiter and R. Denny. Atkins and C. J. Concepts and Models in Inorganic Chemistry. ELBS. Wilkinson. The Chemistry of Macrocyclic Ligands and Complexes. 1990.E. 1965. Oxford University Press. B.. C. 1960. 2004. G. G.H. Cambridge University Press. Houecroft. D. Reinhold Pub. Advanced Inorganic Chemistry. Sutton. Cor.J.L.D. L. J. McGraw Hill. L. Langford. J. F. Cotton and G. Skoog. Electronic Spectra of Transition Metal Complexes. Jr. Lee. Fundamentals of Analytical Chenustry. Ltd. (Ed.. 1990. Thomson and Brooks. Principles. 1960. D. Pearson Education.E.). 10. 2. 2008. Inorganic Chemistry. Concise Inorganic Chemistry. McGraw Hill. P.D.C.1. 5th Edition. 4. 9. 1968. 8th Edition. 5th Edition. Keiter. 3. Pvt. Oxford Scientific Publications. 7. West and Holler. 6. Vogel's Text book of Quantitative Chemicals Analysis. 12.F. 1994. 1988. Shriver. Jeffery. Bassett. Introduction to Solids. 1989. ELBS.W. Madan. S. The Chemistry of Coordination Compounds. Oxford and IBH Publishing Co.D. R. Semiquantitative study of substituent effects on the acidity of carboxylic acids.A. Sundberg. Stability of benzylic cations and radicals. Advanced Organic Chemistry (Parts A & B). 3rd Edition. Qualitative study of substitution effects in SN1-SN2 reactions. Curtius-Hammet principles. Mobius twist and Aromaticity.H. Richardson. Hammet acidity function.S. Criteria for Aromaticity and Antiaromaticity. F. Stabilization of hydrates of glyoxal and chloral. Hammet and Taft equation for polar effects and Taft's steric. Reactive intermediates and their characterizatin. Stereochemical correlations. Potential energy vs Reaction co-ordinate curve. Relative and absolute configurations. Sequence rule – R and S notations in cyclic and acyclic compounds.Sc. March. Thermodynamic and kinetic data. UNIT II : (9 h). mesomeric. Acidity constant. Basic concepts in the study of organic reaction mechanisms: Application of Experimental criteria to mechanistic studies. 4. Neighbouring group participation. 1992. J. 2. T. inductomeric. Resonance and Aromaticity: Qualitative application of Huckel MO theory and perturbation theory to systems containing delocalized electrons. 4th Edition. Quantitative correlation of substituent effects on reactivity. Carey and R. Plenum Press. 3. Harper Collins. Range of the energy of hydrogen bonding. MO description of Aromaticity and Antiaromaticity. 12 . Physical and Mechanistic Organic Chemistry. Kinetic versus thermodynamic control. UNIT III : Isomerism-I (9 h): Concept of Chirality. 1987. Conditions for optical activity. and fused ring systems. acidity. hydroxyl group. High acid strength of maleic acid compared to fumaric acid. Transition state theory. Linear free energy relationships. 1979. Homoaromaticity.A. Optical purity. Lowry and K. Delocalized chemical bonding. CHEMISTRY(CSS PATTERN) – SEMESTER I CH1CO3 – ORGANIC CHEMISTRY – I (4 Credits) (72 h) UNIT I : (9 h). Hydrogen bonding: Inter. acetoxy group.UNIVERSITY OF CALICUT M.J. participation of carboxylate ion. Advanced Organic Chemistry. Electron Delocalization. Cambridge University Press. Fisher projection formula. 1990. Jones. Substituent effects (inductive. halogen. Specific rotation and its variation in sign and magnitude under different conditions. Recognition of symmetry elements and chiral structures. basicity and stability of hydrates of carbonyl compounds. References: (Unit I and II) 1. substituent constant for steric effect. Structure and reactivity. electomeric and field effects) on reactivity. Fullerines. John Wiley and Sons. and ninhydrin. phenyl group and pi-bond. vilatility.Y. Mechanism and Theory in Organic Chemistry. Effect of delocalized electrons on pKa.and intramlecular hydrogen bonding. Aromaticity of Annuelens and heteroannulenes. Delocalized electrons and Resonance. Isotope effect (labeling experiments). R. Effect of hydrogen bond on conformation. physical and chemical properties of organic compounds. Resonance hybrid and resonance energy. R)DIOP. 4. Chiral reagents: BINOL. Warren and P. March. Monosubstituted cyclohexane – methyl and t-butyl cyclohexanes – flexible and rigid systems. 1992. UNIT V : Conformational Analysis – I (9 h): Difference between configuration and confirmation. (cis & trans). Stereochemistry of Aldoximes and ketomines – Naming – isomerism – methods of determining configurations. Nasipuri.H. Greeves. J. New Age International. Conformation of disubstituted cyclohexanes (1:1. erythro and threo isomers. Anchoring group and 13 . Wiley Eastern.4-dimethyl cyclohexanone. n-butane. Conformation of acyclic compounds – Ethane. R and S notations. lithium di(1-phenyl ethyl) amide. Organic Chemistry. acetone). Methods of determination of the configuration of geometrical isomers in acyclic acid cyclic systems. Advanced Organic Chemistry. Camphor derivative in Diels Alder reaction and radical reactions. Geometrical isomerism – E and Z notation of compounds with one and more double bonds in acyclic systems. Oxford University Press. carbohydrates (benzyl D mannose to Swainsonine/preparation of tomolol from D-mannitol). John Wiley. Kalsi. Internal factors affecting the stability of molecules – dipole interaction. Homotopic. Enantiotopic. John Wiley and Sons. 2nd Edition. Restricted rotation in biphenyls – Molecular overcrowding. Chiral auxiliaries: Oxazolidinones. 1:2. Allenes and Nitrogen and Sulphur compounds. 1:3 and 1:4). N. aldehydesand ketones (acetaldehyde. Chirality due to folding of helical structures. Eliel and S. tartaric acid. Stereochemistry of Organic Compounds. Conditions for optical activity. Chiral catalysts: Rhodium and ruthenium catalysts with chiral phosphine ligands like (R)BINAP. bond angle strain. (R. Enzymatic methods. 3.Optical isomerism of compounds containing one or more asymmetric carbon atoms. Optical isomerism in Biphenyls. E. chloro hydrines. 2-bromo-4. Stereochemistry of Organic Compounds. Perspective and Newman projections – representation of different conformations. Wothers. alkene dihalides. Clayden. 5. tartrates. 1994. bond opposition strain. UNIT IV : Isomerism-II (9 h): Asymmetric Synthesis: The chiral pool: Alpha amino acids in the synthesis of benzodiazepines. J. Conformation of substituted cyclohexanone-2-bromocyclohexanone. Prochiral centre. S. 4th Edition. References 1. 2. Interconversion of axial and equatorial bonds in chair conformation – distance between the various H atoms and C atoms in both chair and boat conformations. Wilen. Chiral sulfoxides in controlling the reduction of ketones. Felkin-Ahn model and Cram's chelation control. Diastereotopic hydrogen atoms. 2001. Stereochemistry of Organic Compounds. inter conversion of geometrical isomers. dibromocyclo hexanone.glycols. (h) Oxidation of secondary axial and equatorial hydroxyl group to ketones by chronic acid. Acyl-oxygen and alkyl oxygen cleavage. lactose. Organic Chemistry. (i) 4-t-Butylcyclohexyl tosylate (cis and trans) (ii) 2-Phenylcyclohexanol (cis and trans) (iii) Menthyl and neomenthyl chlorides and benzene hexachlorides.J.2-diphenyl-1-(p-chlorophenyl)-2amino ethanol. John Wiley and Sons. Reformatosky. Advanced Organic Chemistry. Hydrolysis. (g) Hydrolysis of axial and equatorial tosylates. adamentane. 4th Edition. 3. (d) Dehydrohalogination of stilbenedihalide (dl and meso) and erythreo threo.S. MPV reduction and Oppenaur oxidation. Darzons.bromo-1. Cannizaro. UNIT VIII : Introduction to Polymer Chemistry (9 h): Classes of polymers. Plenum Press. E2 eliminations illustrated by the following compounds. 1959. and (ii) an equatorial substituent in flexible and rigid systems. E. Clainson. Perkin. amines and hydrazine. Mechanism and structure in organic chemistry. Synthetic and biopolymers. Stobbe and benzoin condensation.conformationaly biased molecules. neomenthol and neoisomenthol). Morrison & Boyd. F. 3rd Edition. Advanced Organic Chemistry *Parts A & B). Conformations of decaline. (b) E1. Rinehart and Winston. Dieckmann. isomenthol. 4.2-diphenyl propane. Sundberg. Carey and R. Cram's rule. (b) Semipinacolic deamination of erythro and threo 1. cis and trans is 1-butyl and or equatorial sucrose and UNIT VI : Conformational Analysis – II (9 h): Effect of conformation on the course and rate of reactions in (a) Debromination of dl and meso 2. alcoholysis and reduction of nitriles. March. (c) Action of methyl magnesium bromide on 2phenylpropionaldehyde (Stereo chemical direction of asymmeetric induction). J. UNIT VII : (i) Reactions of Carbon-heteromultiple bonds (7 h): Addition of carbon-oxygen multiple bond: Addition of water. Knoevenagel. Gould. Linear. (f) Esterification of axial as well as equatorial carboxyl groups and hydrolysis of their esters. (Compare the rate of esterification of methanol. Esterification of axial and equatorial alcohols and acids – their hydrolysis. Synthetic polymers: Chain reaction polymerization and step reaction polymerization.A. Ritter reactin and Thorpe condensation. Mannich and Prins reactions. (ii) Esterification and Hydrolysis (2 h): Mechanism of Ester hydrolysis and esterification. Wittig. References 1. Conformations of 1:4 disubstituted cyclohexanes in which one of the substituent their importance in assessing the reactivity of an axial substituent. 14 .3dibromobutane or stilbene dibromide using KI. Holt. 2. alcohols. 1990. Effect of conformation on the course and rate of reactions in cyclohexane systems illustrated by: (a) SN2 and SN1 reactions for (i) an axial substituent. 1992. Aldol. Prentice Hall. (c) Pyrolytic elimination of esters (cis elimination) (d) Semipinacolic deamination of cis and trans-2-aminocyclohexanol (e) Esterification of axial as well as equatorial hydroxyl and hydrolysis of their esters in rigid and flexible systems. 1981. S. II. Conversion of cellulose to Rayon. The Chemistry of Nucleic Acids. Sequence determination of peptides and proteins. 2.crosslinked and network polymers. Finar. Biopolymers: Primary. J.H. Structure of RNA and DNA. Natural and synthetic rubbers. Buttorworths. Organic Polymer Chemistry.J.B. Vol. 3. Cram and G. I. Organic Chemistry. 15 . Hendrickson. Organic Chemistry. References 1. Chapman and Hall.L. Pine. 5th Edition. Solid phase peptide synthesis. 1975. Protecting groups. Free-radical and ionic polymerization. Structure of cellulose and starch. McGraw Hill International Book Company. Structure and synthesis of glutathione. secondary and tertiary structure of proteins. D. Saunders. Hammond. Copolymers. Jordean. ELBS. 4.S. C2h and C4V as examples). construction of  cart.Applications of Group Theory to Chemical Bonding (9 h): Hybridisation . Relation between group theory and quantum mechanics – wavefunctions (orbitals) as bases for IR of point groups. inverse of a matrix. direct product and direct sum of square matrices. reduction of reducible representations. block factored matrices. complementary character of IR and Raman spectra. nomenclature of IR .. determination of IR active and Raman active modes of molecules (e. H2O and NH3). complete set of symmetry operations of a molecule. Laporte selection rule for centro symmetric molecules.basis for a representation. derivation of characters of IR using GOT. overlap integrals and conditions for overlap.direct product of irreducible representations and its use in identifying vanishing and non-vanishing integrals. similarity transformation. UNIT IV . sub groups & classes in a group. NH3.Mulliken symbols. SF6).g. Abelian and cyclic groups.symmetry elements and symmetry operations in molecules.THEORETICAL CHEMISTRY II (4 credits) (72 h) UNIT I – Foundations of group theory & molecular symmetry (9 h): Basic principles of group theory .g.treatment of hybridization in BF3 and CH4. Great orthogonality theorem (GOT) (no derivation) and its consequences. Molecular vibrations . (e. Electronic Spectra – electronic transitions and selection rules. solving linear equations by the method of matrices. reducible representations and irreducible representations (IR) of point groups. point groups and their systematic identification. 16 . finite and infinite groups. Mathematical preliminaries .the defining properties of mathematical groups. Molecular Symmetry & point groups . UNIT II – Representations of point groups & theorems (9 h): Representations of point groups .UNIVERSITY OF CALICUT M.  cart ) using the reduction formula.symmetry species of normal modes of vibration. square matrix..g.matrix algebra. selection rules for IR and Raman activities based on symmetry arguments. atomic orbitals and cartesian coordinates positioned on the atoms of molecule (H2O as example) as bases. addition and multiplication of matrices. diagonal matrix. C3V. normal coordinates and drawings of normal modes (e. Matrix representation of symmetry operations. CHEMISTRY (CSS PATTERN) – SEMESTER II CH2CO4 .derivation of reduction formula using GOT. symmetry species. representations using vectors.. relations between symmetry operations. CH4 . Reduction formula . inverse transformation and construction of hybrid orbitals. UNIT III Applications of Group Theory to Molecular Spectroscopy (9 h): Spectral transition probabilities . group multiplication tables (GMT). construction of IR by reduction (qualitative demonstration only). GMT and classes of point groups. H2O. character of a square matrix. construction of character tables of point groups (C2V.Sc. transition moment integral and spectral transition probabilities. fluxional molecules.Rotation spectra of diatomic and poly atomic molecules . spectroscopic term symbols for atoms. intensity of electronic transitions. rotational transitions and selection rules. Karl’s relationships.Electromagnetic radiation & it’s different regions. symmetry adapted linear combinations (SALC). Vibration-rotation spectra of diatomic and polyatomic molecules. effects of chemical exchange. Vibrational spectra of polyatomic molecules. coupling of orbital and spin angular momentum.Magnetic properties of nuclei. symmetric and spherical tops. construction of SALC using projection operator. anharmonicity. determination of bond length using microwave spectral data. The angular momentum of many electron atoms – coupling of angular momenta.COSY. selection rules. classification of atomic orbitals involved into symmetry species. types of electronic transitions. mutual exclusion principle. Vibrational spectra of diatomic molecules .Pure rotational & pure vibrational Raman spectra. 17 . lifetime broadening. dependence of intensity on population. fine structure of H spectrum. use of projection operator in constructing SALCs for the π MOs in cyclopropenyl (C3H3+) cation. Franck . selection rules. spin-spin interaction. Stark effect. combination bands. Morse potential. Raman spectroscopy . Photoelectron spectroscopy (PES) – ultraviolet PES and X-ray PES (qualitative treatment).Molecular orbital theory . LS coupling & J-J coupling. difference bands. spectral branches -P. Origin of molecular spectra Theory of the origin of rotational. isotope effect on rotation spectra. Ground and excited electronic states of diatomic molecules. projection operator. Microwave spectroscopy .harmonic oscillator model. group orbitals.Characteristics of electronic transitions – Vibrational coarse structure. vibrational-rotational Raman spectra. shielding effects. theory and measurement techniques. FTNMR. asymmetric. Q & R branches.H2O & BH3 as examples.rigid and non-rigid rotator models. Electronic spectroscopy of molecules . Dissociation and pre-dissociation.Condon principle. solvents used. vibrational and electronic spectra. line widths. Doppler broadening. Electronic spectra of polyatomic molecules. Principles of 2D NMR spectroscopy . UNIT VII Electronic spectroscopy (9 h): Electronic spectroscopy of Atoms – The energies of hydrogen atomic orbitals & hydrogen spectrum. Laser Raman spectroscopy. transition probabilities. nuclear and electron spin interactions. UNIT VIII Spin Resonance Spectroscopy (9 h): Nuclear Magnetic Resonance (NMR) spectroscopy . Electronic spectra of conjugated molecules. UNIT VI Infrared & Raman Spectroscopy (9 h): Vibrational spectroscopy Normal modes of vibration of a molecule. Rotational fine structure of electronic-vibration transitions. Resonance Raman spectroscopy & coherent anti-stokes Raman spectroscopy (basic principles only). overtones. Fourier transform infrared (FTIR) spectroscopy (qualitative treatment). coupling constant. fundamentals. UNIT V (9 h) : Basic Principles of Molecular Spectroscopy . interaction of matter with radiation and its effect on the energy of a molecule. chemical shift and factors influencing chemical shift. intensity of spectral lines. hindered rotation on NMR spectrum. hot bands. vibrational transitions and selection rules. transition moment integral & selection rules. factors influencing coupling constant. 17. Symmetry & Spectroscopy of Molecules 2nd Edn. 1977.J. 19.Laidler.A Molecular Approach. Orchin. D. 1962. New Delhi.The Mossbauer effect. University Press. Joshi. Houghton Mifflin Company. 15. F. 2006. Palgrave. electric quadruple and magnetic hyperfine interactions. 1963. Kluwer Academic Publishers. 2. H. 1998. Symmetry in Chemistry. Kramer’s theorem. Introduction to Symmetry & Group theory for Chemists. Ltd.Veera Reddy. Affiliated East-West Press Pvt. 1991. Electronic Absorption Spectroscopy and Related Techniques. R. Atkins’s Physical Chemistry.Electron Spin Resonance (ESR) spectroscopy .M. 5. 2003. 18 . L. 3rd Edition. W. University Science Books. Tata McGraw Hill.H. 13. Group Theory and Symmetry in Chemistry. PHI Learning Pvt.. Jaffe and M. Mossbauer spectroscopy .Theory and measurement techniques. 7. 16. Drago. 8th Edition. John Wiley &Sons Inc. A. 8.. Chemical applications of Group Theory. M. 18. Quantum Chemistry & Spectroscopy. H. hyperfine interactions. A. Elements of Group Theory for Physicists. Reference Units I to IV 1.. K. Mark Ladd. Sathyanarayana. 2000. equivalent & non-equivalent protons. 10. P. 14. Fundamentals of Molecular Spectroscopy. Krishnan. Pergamon Press. New Age International 2009. Horwood 1998. Organic Spectroscopy.H. 4.H. Physical methods in Inorganic Chemistry. isomer shift. C. McGraw Hill.. 9. 1965.A. Symmetry & Group Theory in Chemistry. 3. William Kemp. 12. J. Salahuddin Kunju & G. 2006. Symmetry: An Introduction to Group Theory and its Applications.N. Units V to VIII 11. Introduction to Molecular Spectroscopy. Sanctuary. 2004. D. 2010. C. John Wiley &Sons Inc.. Simon. R. hyperfine interactions. New Age International Publishers. Ltd. Pearson education. Physical Chemistry .W. New York. Thomas Engel. McQuarrie and J. Oxford University Press Inc.N. McWeeny. Physical Chemistry.. New York.. Arthur M Lesk. McGraw Hill. 1997. K.D.H. De Paula.S. G. McCash. Atkins & J. Barrow. Freeman & Co. g factor. Hall. 1994. 1969. P. 6. Banwell & E. 1997. Beginning Group Theory for Chemistry.Meiser and B. Cotton. Group Theory & its Applications in Chemistry. London.A. Walton. 2003. 3rd Edn. Imperfections in solids . translational symmetry elements & symmetry operations . ammonia & ethane – eclipsed & staggered conformations). the half wave potential. ferro-electricity and ionic conductivity. UNIT III The Solid State – I (9h): Crystal symmetry: Symmetry elements and symmetry operations.photo conductivity. double zeta. DebyeFalkenhagen effect. Wein effect. Crystallographic point groups . Magnetic properties .point. split-valence. luminescence. The basis set approximation – use of STOs & GTOs as basis functions. introduction to space groups. The structure 19 . piezo electricity.ionic strength. Activity and activity coefficients of electrolytes . variation of activity coefficient with concentration. ferromagnetism.I (4 credits). theories of over voltage. Over voltage . H2O. The Zmatrix. H2. oxygen overvoltage. electron correlation. Derivation of Debye-Hückel limiting law and its various forms. lasers. Decomposition voltage and its determination.diamagnetism. ab initio methods review of Hartree-Fock SCF method. colour centers.Hückel limiting law. Stereographic projections of the 27 axial point groups. paramagnetism. Hall effect. UNIT IV The Solid State – II (9h): Electronic structure of solids .Schönflies & Herman – Maguin notations.Sc.Specification of molecular geometry using cartesian coordinates & internal coordinates. Brillouin zones. concentration polarization. derivation of Debye-HückelOnsager equation. polarization & diffuse basis sets.electrolytic polarization. mathematical proof for the non-existence of 5-fold axis of symmetry.hydrogen over voltage. triple zeta. H2O2. refraction & birefringence. (72 h) Unit I Electrochemistry – I (9h): Anomalous behavior of strong electrolytes.screw axes and glide planes. theory of strong electrolytes. mechanism of electrolytic conductance. Calculations using Gaussian Programme .PHYSICAL CHEMISTRY . ionic atmosphere. Superconductivity Meisner effect. qualitative & quantitative verification of the Debye. Bravais lattices and crystal classes. contracted basis sets. deviation from Debye-Hückel-Onsager equation.thermal conductivity & specific heat. dissolution and deposition potentials. Electrical properties . Model chemistry. band theory & Zone theory.g. line and plane defects. Unit II Electrochemistry – II (9h): Polarization . brief discussion of Cooper theory of superconductivity. Thermal properties . conductance ratio. antiferromagnetism & ferrimagnetism. UNIT V Introduction to Computational Quantum Chemistry (9h): Classification of computational chemistry methods. variation of ionic speeds. dielectric properties. minimal.free electron theory.. Principles of polarography dropping mercury electrode. crystal systems.electrical conductivity. relaxation and electrophoretic effects. relaxation time. Non-stoichiometry. CHEMISTRY (CSS PATTERN) – SEMESTER II CH2CO5 . Optical properties . Pople-style basis sets and their nomenclature. metal deposition over voltage and its determination.UNIVERSITY OF CALICUT M. Z-matrices of some simple molecules (e. degree of dissociation and its determination. range and range energy relation. compound nucleus theory.theory of fluorescence.solar cells and their working. Principles of utilisation of solar energy . Instrumentation of NMR spectroscopy . Jablonski diagram.of a Gaussian Input file.Radiative and non-radiative transitions. specific nuclear reactions. detectors. FTIR spectrophotometer Techniques & instrumentation of Raman spectroscopy – radiation sources. bioluminescence.quenching of fluorescence. Fluorescence . Nuclear Models – Fermi gas. detectors. radiation hazards and therapeutics. stokes antistokes and resonance fluorescence. reaction cross section. Radiation chemistry . dosimetry. cells & sampling devices.Continuous-wave nmr spectrometers – the magnet. conservation. Gaussian keywords . UNIT VII Nuclear and Radiation Chemistry (9h) : Nuclear structure and nuclear stability. UNIT VI Photochemistry (9h): Photochemical reactions . the probe unit. thermoluminescence. 20 . radiation chemistry of water and aqueous ferrous sulphate solutions. Nuclear reactions: Types. H2 .Cl2 reactions.dimerisation of anthracene. Methods of detection & measurement of radiation . Techniques & Instrumentation of UV-Visible spectroscopy – radiation sources. Photosensitization sensitized fluorescence . detectors.principles and working of GM and scintillation counters. collective and optical models.OPT and FREQ as examples. filters & monochromators.Br2 reaction & H2 . neutron activation analysis.processes responsible for energy loss.interaction of radiation with matter . photonuclear and thermonuclear reactions. Physical and chemical radiation effects in solids. radiation sources. UNIT VIII (9h): Techniques & instrumentation of IR spectroscopy – single beam and double beam spectrometers. sample handling. Pulsed FTNMR spectrometer. chemiluminescence photoluminescence. Photochemical processes . photopolymerization. sample handling & illumination. 9. New York.L. NY. D. J. A. Lewars. Introduction to Solid State Physics 7th edn..Reference Units I & II 1. P. 2001. 2007.H. Computational Chemistry: Introduction to the theory and applications of molecular quantum mechanics. 8th Edition. 3. 2006. Wiley-Interscience. 2003 (Reprint 2007). 4. S. Praveen Tyagi. 14. Chemistry and Light.. Introductory photochemistry. John Wiley & Sons LTD 1999. Computational Chemistry. Philip H Reiger. 2006. Azaroff. West. Unit VII 30. Foresman & Aelieen Frisch..K. Gaussian Inc. 27. 26. Atkins & J. Introduction to Solids. Pearson Education Inc. Introduction to Radiochemistry. Reddy. Bockris and A. Dover publications. Introduction to Computational Chemistry.Chapman. 2006.. 29. Modern Electrochemistry. N. Physical Chemistry. I. 2009. 2000. 2nd edn. Quantum Chemistry. Solid State Chemistry & its Applications. Electrochemistry 2nd edn. 5.N. Werner Massa. 1972. Misra. Molecular reactions and Photochemistry . 6. Hamnett. Press. Crystal Structures: Lattices & Solids in Stereoview. 25. Chapman & Hall. Houghton Mifflin Company. K. Atkins’s Physical Chemistry. Giacovazzo (ed. Friedman. 1994. 28. W.V. 11. 6th Edition.. J.. RSC London 1994. John Wiley & Sons. C. Freeman & Co. Hamann.Meiser and B.M.W. 1971. Vol.H. Kluwer Academic / Plenum Publishers. 1981.O. Electrochemistry 2nd edn. DePuy & O. 17. Unit VI 24. 19. Atkins & R. Solid state Chemistry. Errol G. Quantum Chemistry and Spectroscopy. 1965 (Reprint 2008). Essentials of computational Chemistry: Theories and models. McInnes. John Wiley & Sons 2002.W. Suppan. John Wiley & Sons. 21 . P. P. Discovery Publishing House. 2000. Molecular quantum mechanics. Wiley-VCH. C. 1960. Alan Cox & James Kemp.Vielstich.R.Laidler. 23. 15. 20. Oxford Uty. David Young. Springer 2011. W. Basic Solid State Chemistry 2nd edn. 4th Edition. John Wiley & Sons. Electrochemistry. Units III & IV 7. Goel Publishing House. Thomas Engel & W. Mark Ladd. Frank Jensen. G. Ltd. Pearson Education Inc. Glasstone. Kennedy. Crystal Structure Determination 2nd edn. Levine.J. C. Friedlander and J.. Prentice Hall.R. I and II.A. 22.N.H. West. 13. Carl. J. 2003. Prentice Hall. C. 8. 2002. Introduction to Electrochemistry. Springer 2004. John Wiley & Sons. J. East-West Press Pvt. Crystals & Crystal Structures. Hanna. McGraw Hill.B. Hehre. Sanctuary. Oxford University Press. A. McGraw Hill. Photochemistry. 2005. Cramer. 12.) Fundamentals of Crystallography 2nd edn. Exploring Chemistry with Electronic Structure Methods. 2. John Wiley & Sons.. H. 1999. 18. Richard Tilley. De Paula. Unit V 16..S. 2006. 10. 2004 (Reprint 2009).. Horwood. 1999. Raj and H. A. The Principles of Electrochemistry. Charles Kittel. L. 21. 1961. Liljenzin.M. 1991 (Reprint 2005). 43.. 1989. William Kemp. D. 33. A. Tayal.Seaborg. 22 . Banwell & E. 44. Palgrave. Modern Nuclear Chemistry.. S. Robert D Brown.31. Tata McGraw Hill. Fundamentals of Analytical Chemistry. 32. J. Principles of Instrumental Analysis.. Bassett. J.A. Mendham & R.R. C. 1967. Affiliated East-West Press Pvt. Unit VIII 37. Dean & F. 35. J. J. Organic Spectroscopy.. G. F.. Skoog. Krane. 1985. J. Source Book on Atomic Energy. 3rd Edn. Fundamentals of Molecular Spectroscopy. McCash. 4th edn. R. D. J.. H. Holler. PharmaMed Press. 2008. Instrumental Methods of Chemical Analysis 5th edn.J. 38. New Delhi. Thomson and Brooks. Holler & S. 2002. L. 8th edn.J. 1995 (Reprint 2005). D. D. 3rd edn..N.C.C. ELBS.1987 (Reprint 2006). Wiley.D. Denny. Butterworth-Heinemann. 2006. 2004.. Crouch. Willard. 39. G.H. New Age International.H.T. Introduction to Instrumental Analysis. W. 42. West & F.A. J. Ltd.. Arnikar.W. 34.Rydberg. Mc-Graw-Hill. G. 1988 (Reprint 2008). Essentials of Nuclear Chemistry. 40. M. 41. 1994.Jr.O. Vogel’s Text book of Quantitative Chemical Analysis. 36. Merritt.. G.Choppin. 1986. CBS Publishers.L. Nuclear Physics 5th edn. John Wiley & Sons. H.Morrissey. Instrumental Methods of Analysis 7th edn. Thomson and Brooks. Jeffery. 2007. Skoog. Himalya Publishing House. 5th Edition. Glasstone. D.A. Introductory Nuclear Physics. Settle Jr. Kenneth S. Ewing.Loveland. Radiochemistry & Nuclear Chemistry. UNIVERSITY OF CALICUT M. S. S. McGraw Hill International Book Company. Pine. Heck.Villiger. Richardson.E1cB Mechanism . 3rd Edition. J. Favorski.Sc. Warren. 4. Cram and G. Free radical addition and substitution reactions – Carbenes and nitrenes (Formation and reactions). Diel’s . McGraw. Cope and Claisen rearrangements. UNIT III: Molecular Rearrangements and Named reactions (9 hr): Rearrangement involving electron deficient carbon. Wolff Hoffmann. Transition state aromaticity method. F. stability of Free radicals. 23 .H.H. 2. detection. 1976. D. Hendrickson. S. Carey and R. A guidebook to mechanisms in Organic chemistry. References: 1.Meerwein.S. Hammond. Schmidt and Baeyer. CHEMISTRY (CSS PATTERN) . Sigmatropic rearrangement.A. 1981. Greeves. Flemming. Wagner. nitrogen and oxygen atoms.Elimination at bridge head carbonBredt’s rule Chugav reaction. Suzuki coupling. Woodward and Prevost hydroxylation reactions.Alder Reactions.S.J. J. March.Hammond. 1992.Hauser. UNIT IV (9 h) : Spectroscopic Techniques in organic structural determination problem solving approach. Selection rules and their application to the above reactions. References: 1. ene reactions. Orient Longmans. (b) Free radicals (6 hr): Formation. I. Peterson.Cycloaddition and cycloreversion.S. P.Orbital correlation method. Chelotropic reactions. 1990. Mechanism and Theory in Organic Chemistry. Anionic rearrangements: Benzil-Benzillic acid. and P.J. D.SEMESTER II CH2CO6 ORGANIC CHEMISTRY II (4 Credit) (72 hours) UNIT I: (a) Substitution and elimination reaction (3 hr): Nucleophilic aromatic substitution . 2002.B. Wiley. Pinacole-pinacolons. Wothers. 3. Frontier Orbitals and Organic Chemical Reactions. Theoretical models of pericyclic reactions . Clayden. Sundberg. rearrangements. 2001. electrocyclic ring closure and ring opening. Advanced Organic Chemistry (Part A & B). T. Plenum Press. 5. 4. Hendrickson. Pine. Jie Jack Li Name reactions 2nd edition. Harpere Collins. J.H. Organic Chemistry. UNIT II: Pericyclic reactions (9 hr): Definition and types of pericyclic reactions . 2. Beckmann. Organic Chemistry. Organic Chemistry. London. Lowry and K. and Sommelet . J. Sykes.Diazonium ion as synthetic intermediate . Cram and G. Orten-Claisen and Fries rearrangements. Frontier molecular orbital method. Oxford University Press.B. Advanced Organic Chemistry 4th edition John Wiley and Sons. N.J. 3. coupling of protons to other nuclei.UV-visible: Characteristic absorption of organic compounds. 1991. ethers. Kemp and I. Homotopic. Wiley Eastern. Advanced Organic Chemistry (Parts A & B). amines. Nasipuri. 5. enhancement simplification of NMR spectra. 2. References: 1. Spin decoupling and double resonance deuterium labeling and exchange vicinal and germinal coupling in rigid systems. Introduction to spectroscopy. 3rd edition. Alcohols. offresonence.C. Nuclear overhauser effect (NOE). 1990. phenols. John Wiley and Sons. quadrupole broading first and second order spectra.S. 3rd Edition. spin-spin coupling. Kemp.M. Meta stable ions. Axial haloketone rule and its application. periodic acids. Fleming. ELBS. 6. Vol. II.A. Chemical shift correlation charts proton coupled. Principles of Organic Synthesis.Morrill. 1998. G.empirical rules for calculating absorption maxima of dienes. Optical rotatory dispersion – plain and multiple cotton effect curves uses.L. Kalsi. Carey and R. March.J.M. circular dichroism curves.Basslar and T. coupling constant. local diamagnetic shielding and magnetic equivalence. Plenum Press. enones and aromatic systems. 24 . F. alkynes. enantiotopic and diasterio topic protons. Octant ruledetermination of conformation and configuration of 3-methyl cyclohexanone. Spectroscopy of Organic compound. 1975. D.C. Organic Spectroscopy. Lampman and G. IR: Characteristic group absorptions of organic molecules. Silverstein.molecular formulae from isotopic ratio. Wilkinson’s catalyst. Organic Chemistry. ORD curves of cis.L. R. DDQ and diborane. sodium borohydride and their derivatives. Advanced Organic Chemistry. Staeochemistry of Organic Compounds. House. 2. Trimethyl tin hydride. DCC. 4. 3. Kriz.Alkanes.O. use of shift reagent High field strength. alkenes. 1992. New age International. Mass spectra: Determination of molecular mass. D. 7. decoupled and noise decoupled spectra. P. Pavia. Finar. Crown ethers. Organic Spectroscopy. Sundberg.C.3-Dithiane. 1. H. W. peroxy acids. W. carbonyl compounds. 5th edition. and aromatic hydrocarbons. 4th Edition.S. Spectroscopic identification of organic compounds.Million.and trans. G.fragmentation pattern in different classes of compounds. Trimethyl silyl chloride. 1991. References: IV and V 1. John Wiley and Sons.LiAlH4. Gilmans reagent Lithium dimethyl cuprate.delcalones. Lithium dispropyl amide (LDA). UNIT VI: Synthetic reagents (9 hr): Use of the following reagents in organic synthesis and functional group transformations: Complex metal hydrides . J. 3. amides and nitriles. I. M. Saunders Golden Sunburst series. UNIT V: NMR and Mass spectra (9 h): The chemical shift. P. reactions of carbonyl compounds and reactions of aromatic compounds. UNIT VIII: Chemistry of Natural Products (9 hr): Chemical classification of Natural products classification of alkaloids based on ring structure. Terpenoids . Di- -methane rearrangement Barton reaction and Photofries rearrangement photopolymerisation and photochemical degradation of polymers photochemistry of dyes and pigments. 1975.Isolation and classification of terpenoids. I. Chapman.L. Reaction involving the olefinic double bonds. 2. Vol. 25 .L. Finar. ELBS. O.O. molecular excitation.S. Organic Chemistry. Chemistry of Natural products. Isolation and general methods of structure elucidation based on degradative reactions. Kalsi. Woodward synthesis of cholesterol conversion of cholesterol to testosterone. Wiley Eastern. II. 2. structure of steroids classification of steroids. McGraw Hill.Kan Organic Photochemistry. 5th Edition. R. Organic photochemistry. Jablonski diagram and the singlet and triplet states photosensitization.I & II. References: 1. Vol. Flavones and Isoflavonessynthesis only. References: 1. Marcel Decker.UNIT VII: Photochemistry (9 hr): Fundamental concepts. Structure of atropine-synthesis of quinine. J. ELBS. 3. Mn and Ti. Ca. Jeffery.UNIVERSITY OF CALICUT M. An Introduction. Ba. West. G. The Macmillan Company. Underwood. D. Kolthoff and E.M.A. Skoog and D.) and A.H. Zr. 1989. 1969. 1993. Quantitative Chemical Analysis.B.. 5th Edition.L. Fe. (Eliminating acid radicals not present). Basseett. CBS Publishing Japan Ltd. Sandell. Analytical Chemistry. References 1. Prentice Hall of India. Cu.A. 6th Edition. Quantitative Analysis. 26 . E. Meehan. Mendham and R. CHEMISTRY – SEMESTER I & II CH1PO1 & CH2PO1 – INORGANIC CHEMISTRY PRACTICALS– I (4 Credits) UNIT I Separation and identification of four metal ions of which two are less familiar elements like W. Sn2+) 4. Th. Se Te. U and Li. EDTA (Al. nitrite) Potassium Iodate (Iodide.J. Bruckenstein and I. hardness of water) Cerimetry (Fe2+. 4th Edition.Sc. 1986.C. Co. Vogel's Text book of Quantitative Chemical Analysis. J. R. Ti.M. 2. Ni. Ce. S. 4th Edition. Denny. Day (Jr. Mo. UNIT II Volumetric Determinations using: (a) (b) (c) UNIT III Colorimetric Determinations of metal ions Fe. Cr. Ni. V. Confirmation by spot tests. 1964. 1957. UNIT II : Separation and identification of the components of organic binary mixtures.Sc. Shriner. Experimental Organic Chemistry. A. steam and low-pressure distillations. A Laboratory Manual of Organic Chemistry. 2. Fuson and Compounds.S. 4. 1957. 6. 3rd Edition.G. some of which containing compounds with more than one functional group.UNIVERSITY OF CALICUT M. Bajpal. ELBS/Longman. fractional crystallisation and sublimation. Cartin.J. Dey. Vol. 3. Vogel's Textbook of Practical Organic Chemistry. 27 .W. P. Systematic Identification of Organic Fieser. 1980. CH2PO2 – ORGANIC CHEMISTRY – I (4 Credits) UNIT I : Laboratory Techniques Methods of Separation and Purification of Organic Compounds – fractional. I and II. D. Vishnoi. Analysis of about ten mixtures. CHEMISTRY – SEMESTER I & II CH1PO2. Tatchell.R. Gupta and K. Singh.S. References 1. Experiments in Organic Chemistry. 5.C. Hannaford. P. 1989. Practical Organic Chemistry. B.R. Sitaraman and Govindachari. Smith and A. Furnis. 2. verification of Ostwald's dilution law and calculation of dissociation constant. methanol. glycerol) Determination of composition of liquid mixtures (e.g. benzenenitrobenzene. Determination of molecular weight of a polymer (e. 2.Physical Chemistry Practical – I (4 credits) SECTION A UNIT I. Determination of molar heat of solution of a substance (e. glycerol-water) Determination of molar refraction and refractive index of a solid substance UNIT VI .. succinic acid) from solubility data .g. 2. Determination of equilibrium constant of KI + I2 = KI3 Determination of concentration of KI solution SECTION B UNIT V . Determination of distribution coefficient of I2 between CCl4 and H2O. 2. (a) Determination of phase diagram of a simple eutectic system (e. 2. Naphthalene – m-dinitrobenzene). Distribution Law (minimum 3 experiments) 1.. Determination of phase diagram of a binary solid system forming a compound (e. ammonium oxalate.UNIVERSITY OF CALICUT M.g.Conductivity (minimum 4 experiments) 1.g..g. ethanol. chloroform. Determination of solubility product of a sparingly soluble salt (e. Determination of equivalent conductance of a weak electrolyte (e.analytical method and graphical method UNIT II. Viscosity (minimum 2 experiments) 1. BaS04) 28 .. Solubility and Heat of solution (minimum 2 experiments) 1. alcohol-water. UNIT III. Naphthalene – Biphenyl. polystyrene in toluene).g. 3.. AgCl.Verification of Kendall’s equation (e.. CH2PO3 . acetic acid).g.g.Sc. 3.Refractometry (minimum 3 experiments) 1.g. Naphthalene-Diphenyl amine) (b) Determination of the composition of a binary solid mixture. Viscosity of mixtures . Determination of molar refractions of pure liquids (e. Phase Equilibria (minimum 3 experiments) 1. UNIT IV... CHEMISTRY (I & II Semesters) CH1PO3. carbon tetrachloride. water.. water-alcohol). Cambridge University Press.B. Experimental Physical Chemistry. 7. P. A. Practical Physical Chemistry. Harriman. D. Longman.M. 6. McGraw Hill. 2nd Edition. 2. 3. James. B.A.G.S. Conductometric titrations (a) HCl vs NaOH (b) (HCl + CH3 – COOH) vs NaOH Determination of the degree of hydrolysis of aniline hydrochloride UNIT VII . A.P. C. 29 . Potentiometric titration: HCl vs NaOH. 2. Shoemaker and C. Garland. 1970. Experimental Physical Chemistry. Practical Physical Chemistry.D. W. Read Books (Reprint 2008). Experimental Physical Chemistry. Goel Publications. 1974. Finlay. CH3-COOH vs NaOH Redox titration: KI vs KMnO4. 8. 2009. 5.E. Bender. Viva Books.3. Cornwell and J.W. J. Practical Physical Chemistry. Firth. B. Williams. 1962. 4. Viswanathan & R.Potentiometry (minimum 3 experiments) 1. Alberty. Raghavan. 3. 1989. F. McGraw Hill. J. J. FeS04 vs K2Cr2O7 Determination of dissociation constant of acetic acid by potentiometric titration References 1. 4. Yadav.W. Practical Physical Chemistry. Palmer. Advanced Practical Physical Chemistry. Daniel. Longman’s Green & Co. R. CHEMISTRY (CSS PATTERN) – SEMESTER III CH3CO7 . UNIT II . Fermi . ensembles. Effect of solvent and ionic strength (primary salt effect) on the rate constant. general theory of non-equilibrium processes. Kinetics of fast reactions. UNIT III Statistical Mechanics III (9 h): Quantum statistics . entropy production. Heat capacities of gases . idea of microstates and macrostates. 30 . statistical mechanics for systems of independent particles and its importance in chemistry.Sc. UNIT IV Thermodynamics of Irreversible Processes (9 h): Simple examples of irreversible processes.relaxation methods. X-ray diffraction studies of simple liquids.Structure of liquids. short range order.Rice . The molecular partition function and its relation to the thermodynamic properties. Kinetics of chain reactions – branching chain and explosion limits (H2-O2 reaction as an example).Statistical Mechanics .classical and quantum theories. configurational partition function for liquids.II (9 h): Heat capacities of solids classical and quantum theories. Maxwell-Boltzman statistics. communal entropy in liquids. Sterling approximation.Herzfeld mechanism and steady state approximation in the kinetics of organic gas phase decompositions (acetaldehyde & ethane). relation between molecular & molar partition functions. equilibrium constant & equi-partition principle in terms of partition functions. electro-kinetic effects. Relationship between Maxwell-Boltzman.PHYSICAL CHEMISTRY II (4 credits) (72 h) UNIT I . the corresponding contributions to the thermodynamic properties. ortho and para hydrogens. secondary salt effects. statistical weight factor (g). thermal diffusion.Dirac distribution law. Onsager reciprocal relations. and Fermi-Dirac statistics. thermodynamic probability & entropy. UNIT V – Chemical Kinetics (9 h) : Kinetics of reactions involving reactive atoms and free radicals .I (9 h): Fundamentals – concept of distribution. the Glansdorf-Pregogine equation. application to electrons in metals. The liquid state . vibrational and electronic parts. Bose-Einstein condensation. thermo-osmosis and thermo-molecular pressure difference. rotational. the phenomenological relations. Einstein’s theory of atomic crystals and Debye’s modification. application to liquid helium.UNIVERSITY OF CALICUT M. thermodynamic probability and most probable distribution. application to the theory of diffusion. Bose-Einstein.free volume theory & simple hole theory.Bose Einstein distribution law. derivation of third law of thermodynamics. flash photolysis. molecular beams. Evaluation of partition functions and thermodynamic properties for ideal mono-atomic and diatomic gases. Solution kinetics: Factors affecting reaction rates in solution. radial distribution function.Statistical Mechanics . factorisation of the molecular partition function into translational. the anomalous heat capacity of hydrogen. theories of liquids . heat of adsorption and its determination. Prince Hall India. 8. Chemical and Process Thermodynamics. EastWest. S. ESCA & Auger spectroscopy. Statistical mechanics.K.unimolecular surface reactions –bimolecular surface reaction –Langmuir-Hinshelwood mechanism and Eley-Rideal mechanism – illustration using the reaction 2CO + O2 → 2CO2 Reference Units I to IV 1. Rice-Ramsperger and Kassel (RRK) model. Statistical Thermodynamics.oscillating reactions – mechanisms of oscillating reactions (Lotko-Volterra. UNIT VIII – Catalysis (9h): Homogeneous catalysis – mechanism Arrhenius intermediates and van’t Hoff intermediates. Hinshelwood’s modification. Freeman and Co. Statistical distribution of molecular energies.Auto catalysis . Potential energy surfaces attractive and repulsive surfaces. Wiley eastern Ltd. 4. Hill.Rice. 10.S.Molecular beams. Experimental methods for studying surfaces . The dynamics of molecular collisions . 1993. Statistical mechanics.Principles of SEM.A. Statistical derivation of Langmuir isotherm. STM. Interscience B. G. Guptha. Huary. Pergamon Press. 7. London equation. Introduction to statistical thermodynamics. Berker. Thermodynamics and Kinetics. Addison Wesley. brusselator and oregonator) Heterogenous catalysis –adsorption and catalysis. M.UNIT VI – Molecular Reaction Dynamics (9 h): Reactive encounters: Collision theory.. University Press. John Wiley. Andrews. K. F.C. An introduction to Thermodynamics of irreversible processes. 2nd Edn. Prentice Hall of India 9. Vemulapalli. O.K. Glasstone. Units V & VIII 31 . Physical Chemistry. Theories of unimolecular reactions Lindemann’s theory. Langmuir's unimolecular theory of adsorption. diffusion controlled reactions. Oxford 2. Comparison of collision and activated complex theories.L. Equilibrium statistical mechanics. BET equation. thermodynamic aspects of ACT. J. 6. principle of crossed-molecular beams. 1963. the material balance equation. Statistical mechanics. 3. G. UNIT VII – Surface Chemistry (9 h): Adsorption: Adsorption isotherms. John Wiley and sons.G. 11. 1973 Pigoggine.C. 5. determination of surface area of adsorbents. Kyle. Thermodynamics for Chemists.MichaelisMenten Mechanism.acid base catalysis – specific and general acid catalysis – enzyme catalysis. T. Lattice theories of liquid states. derivation. Rush Brooke. Activated Complex theory – the Eyring equation. Thermodynamics and Kinetics. K. Printice Hall of India. P. W. Pearson Education. Adamson. Physical Chemistry. A. Freeman & Co. New York. The Physics and Chemistry of surfaces. Chemical Kinetics and Dynamics 2nd edition. Physical Chemistry of surfaces. C. 2006.. Steinfeld. 8. De Paula.H. Physical Chemistry. Francisco and Hase. Atkins’s Physical Chemistry. Chemical Kinetics and Catalysis. 6. Masel. 2006. Wiley Interscience. 2003. 1982. 4th edition.Meiser and B. M. 7. 2001. 2.. 9. G.H. 3.Laidler. Sanctuary. Dover Publications 32 . Atkins & J. Richard I. K. New York. Springer. Keith J. Vemulapalli. Chemical Kinetics and Reaction Dynamics. K.1. Adam. 4. 8th Edition.W.J. Upadhyay. J. Inc Santhosh K. 5. Laidler. Houghton Mifflin Company. 1987 (Indian reprint 2008). Interscience. Prentice Hall International . Chemical Kinetics 3rd edn. Unit III (9 hr): Reaction mechanisms of metal complexes. Synthesis. bulk and trace metal ions. photoaquation and ligand exchange reactions. potassium and calcium in biological system. Temperature independent paramagnetism.application to copper complexes.Eigen equation. Unit VI (9 hr): Organometallic compounds I .metal complex sensitizers.IR spectra of metal carbonyls . Classification. Charge transfer spectra. outer sphere and inner sphere electron transfer. syntheses. Spin cross over in coordination complexes. C5H5– and C6H6. Changes in ligand vibrations on coordination. Trans effect. structure. Aquation and base hydrolysis.metal ligand vibrations. Unit VIII (9 hr): Introduction to bioinorganic chemistry. synthesis. Orgal diagram and its uses. Determination of magnetic moment.theories and applications. Organometallic compounds of transition metals. carbenes. Fuoss.Sc. bonding and reactions of typical transition metal complexes of C4H4. Substitution reactions in octahedral complexes. carbynes. Effect of ligand field on RS terms. Spectoral application of coordination compounds . Rate laws.  . Role of sodium.ESR spectra. butadiene and acetylenes.INORGANIC CHEMISTRY II (4 Credits) (72 h) Unit I (9 hr): Electronic spectra of complexes. photochemical reactions of metal complexes. allyl. Carbon  . structure and bonding in metal carbonyls. structure. A. Spectra of fblock complexes. Effect of the nature of metal ions and ligand on the stability of the complexes.Classification and nomenclature. structure.application to iron complexes .synthesis. Bridging group effects.types of magnetic properties paramagnetism and diagmagnetism. Alkyls and aryls of main group metals. Spin-orbit coupling. Photosubstitution. classification. magnetic properties of f-block elements. Mossbauer spectra.Application of NMR spectra of diamagnetic complexes.Gouy method. Ferro and antiferro magnetic interactions. bonding and applications.  Orbital magnetic 1+s and spin only expressions. occurrence of inorganic elements in biological system. Unit II (9 hr): Magnetic properties of metal complexes. selection rules. bonding and applications of complexes of ethylene. Group frequency concept. Tanabe-Sugano diagrams. CHEMISTRY (CSS PATTERN) SEMESTER III CH3CO8 . D and I mechanisms.UNIVERSITY OF CALICUT M. Unit IV (9 hr): Redox raction mechanism. Unit V (9 hr): Infrared spectra of metal complexes. The 18 electron rule. Metalloenzymes: 33 .Curie an Curie-Weiss law. moment and its quenching. The cis-effect.Coordination of transition metals to carbon multiple bonds. Marcus equation. Term of dn configurations.donors. Unit VII (9 hr): Organometallic compounds II . coordination sites in biologically important ligands. photochemical reactions of chromium and ruthenium complexes. Substitutions in square planar complexes. L. R. G. Introduction to Magnetochemistry. 16. J. 4. 1960. Nitrogenases. R. 1968.F. The Chemistry of Coordination Compounds. 1994. 1982. University Science Books. D.J. Affiliated EastWest Press Pvt.W. 1984.W.. chlorophyll-photosystem 1 and I. Wiley. 1991. H. 14. 1989. Lippard and J. D. Academic Press. Cambridge Books. 8. tyrosinase. 9. 2001. copper enzymesoxidase. 1994. Inorganic Chemistry. Inorganic Chemistry. Gray.A. Structure and Reactivity. Elements of Magnetochemistry. 3. S. 1998. 13.Wiberg.C.S.L. Biocoordination Chemistry. Principles of Organometallic Chemistry. ELBS. Cotton and G. Inorganic Chemistry. 2. 19. L..B.A. Lindoy. 1995. Keiter. University Science Books. Organometallic Chemistry. iron enzymes. Principles. 15. 1990. D. Ellis Horwood Ltd. 1995.. Keiter and R.F. J. 17. 18. Holleman. I. Valentine. 11. Cytochromes and iron-sulphur proteins.H. E.S. Dutta and A. Tarr. G. L. 7. Fenton. McGraw Hill. Blair Jr. 1988. Lindoy. 12.A. biological nitrogen fixation. Person Education.Wulfsberg. S. Inorganic Chemistry. 2004. S. R. ELBS. (Ed.L. The Chemistry for Macrocyclic Ligands and Complexes.E.. Oxford University Press. 6. Sutton. Ltd. Ltd. Cambridge University Press. Atkins and C. 1977. A Unified Approach.. Academic Press. Powell. Lippard and J. Pearson Education.Zn(II) containing enzymes. Reinhold Pub. 1968. Vitamin B12 and coenzymes. References: 1. peroxidase. Bertin. 34 . superoxide dismutase.).M. Wilkinson. Advanced Inorganic Chemistry. Cor. Shyamal. Earnshaw. Huhey. Electronic Spectra of Transition Metal Complexes. Wiley Eastern. Mehrothra and A. Bioinorganic Chemistry. Physical methods in Inorganic Chemistry. Langford. A. 5. The Chemistry of Macrocyclic Ligands and Complexes.C.F. Viva Books Pvt. 2nd Edition. Shriver. Hay. Chand & Co. Inorganic Chemistry.. P. P. F.E. Miessler and D. Bioinorganic Chemistry. Principles of Bioinorganic Chemistry. R. Berg. Drago.J. Singh. 10. 2000. UNIT II (9 hr): (i) Formation of Carbon-Nitrogen Bond (9 hr): Nucleophilic nitrogen and electrophilic carbon. 1965. CHEMISTRY (CSS PATTERN) – SEMESTER III CH3EO1 Synthetic Organic Chemistry (Elective) (4 credits) UNIT I: Formation of Carbon-Carbon bond (9 hr): Carbon. Warren. Carey and R. 1987. Plenum Press.O. Sundberg. Metal hydride reductions. glycols. Organic Synthesis. oxidative-decarboxylation. Smith. alcohols. R. and aldehydes. 5.Carbon bond formation via Electrophitic and nucleophilic carbon species.UNIVERSITY OF CALICUT M. (ii) Formation of Carbon-Halogen Bond: Allylic halogenation by NBS. 4. 4th edition. 1. John Wiley. Oxidation with transition metal oxidants (Cr. 3. Hendrickson. Organic Synthesis. Cambridge University Press. References: 1.A.A.J.O.carbon double bonds. Bischler. R. O3. Michael and B. 2. Modern Synthetic Reaction.reduction of alkenes. F. March. Ketones to methylene group reductive ring opening of epoxides. References: 1. Smith. alkynes of aldehydes and ketones to alcohols. Carey and R. Base catalysed condensations. Advanced Organic Chemistry. John Wiley and Sons. House. Norman. W. 3rd Edition.J. UNIT III: Reduction and Oxidation (9 h): Catalytic hydrogenation. dissolving metal reductions. and peroxides. H. NCS and NIS photochemical methods of organic synthesis (suitable example). Carruthers.A. Modern Methods of Organic Synthesis.K. R. S.Napiaralski reaction. reduction of aromatic and heterocyclic compounds. ketones. Advanced Organic Chemistry Part B. 2. four centre reactionDiel’s Alder reaction. lead tetra acetate and ScO2 oxidation of carbon. 4. Reduction of specific functional group. The Disconnection Approach. Cram and Hammond. allylic oxidation.C. R. Electrophilic nitrogen and nucleophilic carbon skrarp synthesis. J. 3.3-dipolar additions. 1992. Principles of Organic Synthesis. F. Reduction of unsaturated carbonyl compounds. References: 1. 2. 35 . Benjamin. W. Michael and B. Mannich base as intermediates in organic synthesis. Sundberg.Sc. 3rd Edition. Organic synthesis. Principles of Organic Synthesis. Advanced Organic Chemistry Part B.O. Norman.K. Mn) Oxygen. Plenum Press.C. Organic Chemistry. S. Sorenson. 1994. Ou primer 3 oup. Organometallic reagents in synthesis. disconnections and functional group interconversions.a case study. M. London. Norman.O. 5. Stuart Warren Designing. E. V.O. Sonogashira cross coupling reaction (Mechanism. 1996. 6. 2000. Micheal Smith. Special techniques. regio.J. 7. Pergman Press. Principles of Organic Synthesis.B. Cadmium. UNIT VI: Synthesis of Natural Products (9 hr): Synthetic studies on Longifolene. reagents. uplong reactions and use in synthesis. Organic synthesis. Corey and I. VCH. 1925. Jenkins. Vitamin A. Academic Press. John Wiley and Sons.C. Organotransition metal chemistry application to Organic Synthesis. protective groups for hydroxyl. Organic Synthesis. Fieser and Fieser. I. 3. Modern Synthetic Reactions. Plenum Press. Synthetic applications in Cyclic peptides) Stille carbonylative cross coupling reaction (Mechanism and synthetic applications). 6. Types of selectivities (Chemo. Logic of Chemical Synthesis.J. Fleming. catalysts. Some modern methods of Organic Synthesis. T. Daus. Organic Synthesis. P. John McMurry. and Fe.1989. Reserpine. Classics in Total synthesis K. I. Finar. 36 . 4. 2. Benzene Tricarbonyl Chromium. E. McGraw Hill. Zinc.L. Carbonyl and carboxylic acids. Palladium catalyzed amine arylation (Mechanism and Synthetic applications). New York. preparation and reaction with carbanions. UNIT V: Multi step Synthesis (9 hr): Synthetic analysis and planning. McGraw Hill. leaving groups synthesis and synthetic equivalents. W. Cephalosporin. Elements of a Synthesis (Reaction methods. Prostaglanden E. 4. 2nd Edition. House.C. 1972. John Wiley. Tri-n-butyl tin hydride. organometallic reagents of Aluminium. or newer. 3. Vol. 3. References: 1. Carey and R. 4.Nicolaou. References: 1. London. Advanced Organic Chemistry Part B. Organic Chemistry. Reagents in Organic Synthesis. stereo selectivities) synthetic planning illustrated by simple molecules. 2. ELBS. 3rd Edition. Selected Organic Synthesis. Benjamin Publications. Carnethers. solvents. Ahluwalia and R. Chang. F. 1989. 5th Edition. Smith.A. Gilman’s reagent. R. References: 1. II. Landbery. 2004.M. H.G. Strategies and Tactics in Organic Synthesis. 2nd edition. 1982. Organic Chemistry.K. Retrosynthetic analysis of a complex molecule. UNIT VII: Palladium Catalysed Coupling Reaction (9 h): Palladium Catalysts for C-N and C-O bond formation. 5. 1982.R. 2. Agarwal Organic Synthesis. Narose. California. Sundberg. Programmed introduction to the synthesis approach.UNIT IV: Reagents in Organic Synthesis (9 hr): Use of the following reagents in organic synthesis and functional group transformation complex metal hydrides. amino. activating groups. 5th Edition. Metal Catalysed cross coupling reactions. common structured types. 3. 2005. 5th Edition. pyrazole. 1961. tetrazole. Farine. Elcener Academic Press.J. F and Stang P.. The stille reaction. Eds. New York. Synthesis of uric acid. UNIT VIII: Heterocyclic compounds (9 hr): Aromatic and nonaromatic heterocyclic.II. Academic Press. Synthesis of adenine and guanine. synthesis of furanones. 1998. The Chemistry of Heterocyclic Compounds. imidazole and thiazole synthesis of uracol. John Wiley and Sons. Lazzlo Kurti and Barbosa Czako.L. structure. caffene.J. 2. Finar. An introduction to the chemistry of Heterocyclic compounds. References: 1. V. ELBS.. Interscience. Krishnamurthy. 3. thymine and cytosine. Organic Chemistry. 1988. Vol. New York. V. I. 1960. Acheson. Dieckrich. 1975. Wiley. 2. Scott W. VCH. Badger. pyrazine. 37 . synthesis and reactions of oxazole. Strategic application of Named reactions in Organic synthesis.References: 1. alkaloids. Terpenoids. 4. Newman (Ed. ELBS. Economic Botany. Pinder. Calcutta. Cholesterol. Natural Products Chemistry. Ergocalciferol. Bot. Oxford University Press. Oesterone. Natural Products Chemistry. adathoda Vasica and Rawolfia serpentina.Sc. 2. (ii) Classification of Natural Products: Classification of Natural products based on chemical structure.B. J.S. I. ELBS. Lawrence. The Classification of Flowering Plants. anthocyanins etc. A. Shoppe. Cholic acid. Kodansha Scientific Ltd. I. physiological activity. 1975. storage and uses of the following medicinal plants. Vol. Testosterone. 5. 5.II. P. 4. Classification and general structure elucidation of terpenoids. Finar. Equilenine. 1975. References: 1. UNIT II: Terpenoids (9 hr): Methods of isolation. Gamble. References: 1. 6..S. An Introduction to the Chemistry of the Terpenoids and Steroids. N. 2. Cortisone and Corticosterone.UNIVERSITY OF CALICUT M.R. The higher Terpenoids. cultivation. Klyne.. Sivarajan and Manilal K. collection. structure elucidation of Farnesol and Menthol. Bile acids. Cambridge University Press. Chemistry of the steroids. The Chemistry of Terpenoids. Flora of the Presidency of Madras.V. Organic Chemistry. 5th Edition. Simonson. The chemistry of steroids. Koji Nakanishi. The Chemistry of Terpenes. 4. steroids. 1959.L. Templeton. De Meyo. A. and Shige Nozoe (Eds. New Delhi. 1974. Finar. Oestriol. Rendle. isoprene rule. 2. Vol. Sho Ito.II. 5. Hill. CHEMISTRY (CSS PATTERN) SEMESTER III CH3EO2 : NATURAL PRODUCTS (Elective) (4 Credits) UNIT I: (9 hr): (i) Taxonomy of Plants: Location. Asia Publishing House. stereochemistry of camphor and abeitic acid. 38 . 1974. Androsterone. 1871. V. UNIT III: Steroids (9 hr): Classification and isolation of steroids. Carbohydrates. Diosgenin. 3. Vol. identification. 1957.A. Synthesis of Lupeol and  -amyrin. Methods of isolation of each class of compound.R. Steroids. Organic Chemistry. Flora of Calicut.Ocimum sanctum. Fieser and Fieser. 5th edition. Toshio Goto. Detailed study including structure elucidation.). taxonomy and Biogenesis. Phyllanthus. synthesis and stereo-chemistry of the following. Carotenoids.L. Oestradiol. 3. Survey of India. Ergosterol. Shinsaku Natori. Progestrone.). 3. Terpenoids. I. Taxonomy of Vascular Plants. 7. Krishnaswamy. References: 1. A. Organic Chemistry. Kodansha Scientific Ltd. Plenum Press. References: 1. Bible.. Shinsaku Natori. 1960. Koji Nakanishi. Vol. 1974. 3. I. 1952. J. 3. Sho Ito. Geissman (ed. Pergamon. The Alkaloids-chemistry and Physiology. Optical Rotatory Dispersion. UNIT VI (9 hr): (i) Application of IR. and Shige Nozoe (Eds. Alkaloids. Koji Nakanishi. William and Fleming. K. Maniske and H. Bentley. chromatography and other techniques of purification.B. D..UNIT IV: Alkaloids (9 hr): Nomenclature. 5. Comparative Biochemistry of Flavonoids. Finar. Vol. 1975. 2. I. ii) Haemin and Chlorophyl: Structure and synthesis of Porphyrins. General Nature and Structure of Anthocyanidins. Reserpine.S.H.. Interscience. 5th Edition.. Tylophorin and Lysergic acid.W. Holmass.). 4. classification. Optical Rotatory Dispersion and Circular Dichroism in Organic Chemistry. Crabbe. Bernfell (ed. Vol. 2. Bentley. Harborne. Holdern Day. Pergamon. McGraw Hill. 3. 1965. J. PGF. Sho Ito. 5. The Natural pigments.). 1974. 4. 1965. References: 1. McGraw Hill. 2. Vol. Biogenesis of Natural Compounds. Spectroscopic methods in Organic Chemistry. 5. Organic Chemistry. Academic Press. and Shige Nozoe (Eds. Toshio Goto. 39 . 4. UNIT V (9 hr): (i) Anthocyanins: Introduction.II.L. Isoflavone (Daidezein) and Chalcone. 1967. (ii) Prostaglandins: Chemistry of Prostagiandins. Natural Products Chemistry. References: 1. Organic Chemistry. Finar. Djersassi. ELBS. Hammond. I. 1964. 2. Natural Products Chemistry. Pine.L.I to IV. Vol. Oliver and Boud. 6. Interpretation of NMR spectra.L. 5th Edition.II.). Structural elucidation and Synthesis of PGE. 1965. Mass. The Chemistry of Flavonoid Compounds. Kodansha Scientific Ltd. Determination of Organic Structure by Physical Methods. ELBS. Cram and G. Shinsaku Natori. 1975. Physical Methods in Organic Chemistry. References: 1. Detailed study of the following.L. R. Toshio Goto. 1975. 5th edition. References: 1. CD and ORD in the structural elucidation of Natural products. PGA and PGB groups of prostaglandins.). McGraw Hill International Book Company.). Flavonol. 1966.Isolation. Academic Press Inc. 1981. Henry. Chemistry of Haemin and Chlorophyl. isolation. Vol. Finar. II. UV. Quercetin.F. Organic Chemistry. Interscience Publishers. The Plant Alkaloids. Classification. NMR.H. Flavone. ELBS. Morphine. I. S. Academic Press. I. Hendrickson. Schwarz (Ed. citronella oil. sandalwood oil. Essential oils of turmeric and ginger. K. References: 1. References: 1. Riboflavin. Organic Chemistry by I. 2. Leneinger’s Principles of Biochemistry. Niacin. use of essential oil in medicine. Cox. isolation. Organic Chemistry by I. II.2. cinnamon oil. II. The essential oils. E. agowan oil. 2. Oleoresins of pepper. Worth Publishers. turpentine oil. Chemistry of Natural Products by Bhat.C. Vol. The constituent of essential oils by Ernest Guenther. 40 . peppermint oil. clove oil.Aromatherapy. palmarosa oil. patchouli oil. rose oil.L. Finar. Thiamine. chilly. 1975. rosemary oil. ginger and turmeric. UNIT VIII: Vitamins (9 hr): Occurrence. D. Pyridoxine. New York. Vol. 2005. lavender oil. biological significance (brief idea) and synthesis of the following vitamins: Vitamin A. Finar. Narosa Publishing. Nagasampagi and Sivakumar. Nelson and M. UNIT VII: Essential Oils and Aromatics (9 hr): Isolation and study of important constituents of lemon grass oil. Pantothenic acid and ascorbic acid. observation. Preparation of ion exchange resins. Molecular weights and its distribution. Transfer and termination. gelpoint. block and graft co-polymers and stereo specific polymers. Reactivity and structure of monomers and radicals. Ring verses chain formation. Polymer Chemistry (Elective) (4 Credits) UNIT I: Methods of Polymerization (9 hr): Step reaction (Condensation) Polymerization: Mechanism. types and Kinetics of condensation polymerization. thermosets and thermoplastic. Mechanism of Vinyl polymerization. Degree of polymerization-chain transfer. Post reactions of polymers. cationic polymerization.Initiation and Propagation Mechanisms. Molecular weight distribution. Bulk polymerization and polymer precipitate. enthalpy.UNIVERSITY OF CALICUT M. Unperturbed chain dimension. immobilized enzymes. Gas phase polymerization. Chemistry of copolymerization. Co-ordination Chain Polymerization: ZieglerMechanism. Polymer blends. Experimental methods in Vinyl polymerization.gelation. composition of copolymers. 41 . UNIT IV: Classification of Polymers (9 hr): Plastics. Radiation activated polymerization. entropy an free energy change in polymer dissolution. random. Kinetics. Ionic equilibrium.Sc. polymer analogues reactions. Molecular and chemical groups. Ring scission polymerization. Ionic Polymerization: Anionic polymerization. linear. UNIT II: Method of Polymerization II (9 hr): Suspension and emulsion polymerization of mono and hetrodisperse polymers. Polymerization in homogenous and heterogeneous systems.Mechanis. osmotic pressure. Radical Chain (Addition) Polymerization: Vinyl polymerization. Interfacial condensation. The co-polymerization equations. CHEMISTRY (CSS PATTERN) – SEMESTER III CH3EO3. Living polymerization.Chain Extension. Molar mass distribution. viscosity of polymer solution. polymer-bound reagents. Polymer Degradation reactions. Vinyl monomers. Solid phase peptide synthesis (SPPS) merits and demerits. branched and cross-linked polymers. Co-polymerization: Different types of copolymers. kinetics of copolymerisation (Free radial and Ionic). Reactivity of functional groups. Mechanism of co-polymerization. Bifunctional and Polyfunctional step reaction polymerization. stereocontrol. Kinetics of free radical polymerization. Kinetics. Natta Catalysis.Ring opening polymerization. UNIT V: Polymer Solutions (9 hr): General role of polymer solubility parameters Flory-Huggins treatment of polymer solution. Branching and gross linking reactions. Functionalization of polystyrene. rubbers and fibers.Monimer reactivity ratios and co-polymerisation parameters. Effect of temperature and pressure on chain polymerization.experimental. Kinetics. UNIT III: Chemical reactions of polymers (9 hr): Basic principles. concentration dependence of colligative properties. Thermal. empirical correlations between intrinsic viscosity and molecular size of polymer structure. UNIT VII: Polymer Degradation (9 hr): Mechanism of Polymer degradation. cellulose acetate. End-group analysis. phase separation in polymers.Teflon. Polyamides (Nylon) and Polyesters (Terylenes) Carprolactam based polymers. Glass transition temperature. 42 . UNIT VI (9 h): Studies on the thermal. Ultra centrifugation. electrical and mechanical properties of polymers. Polyolefins. Acid and base hydrolysis. Bio-degradation of polymers. Vinylpolymers. Solution viscosity and molecular size. Oxidation and ozone attack. optical. staudinger index.Native and modified cotton Rayon. Vapour pressure lowering. treatment of data. Polystyrene. cryoscopy and osmometry.Polyethylene and Polypropylene.swelling of polymers. Flurocarbon polymers. Phenol formaldehyde and urea formaldehyde resins. Method of molecular weight determination of polymers. Gel permeation chromatograph and other chatographic techniques in the fractionation polymers. Light-scattering methods. acrylic polymers.PVC. correlation of structure to these properties. experimental methods. UNIT VIII: Structure and applications of the following (9 hr): a) b) c) d) e) f) g) Cellulose and cellulose based polymers. First order and second order transition points. colligative property measurement. Cellulose nitrate. Melting temperature.Experimental method of their determinations. mechanical and photochemical degradations. fractionation of polymers. 1980. Academic Press. Campbell. ‘Introduction to polymers’. 1968. Text Book of Polymer Science. 6. Buthesworthes. Oxford Scientific Publications. 2.W. London. ‘Principles of Polymerization’. 43 .M. 5. The structure of Polymers Reinhold.) ‘Rubber Technology and Manufacture’. ‘Macromolecules’ Plenum Press. F. Miller. 1982. Wiley-Inter Sciences (1976). 1970.L. Saunders. ‘Polymers as Aids in Organic Chemistry. K. ‘Organic Polymer Chemistry Chapman and Hall. London. Blow and C.M. Billmeyer. 1994. M. Narang and Williams. McGraw Hill. Eiias. 7. Mathur. J.References 1.Odian. 4.Hephrun (eds. I. 3. C. G. solvents. principles of green chemistry. planning of green synthesis. Fischer-Trops reaction. protic engineering. Wacker process Dimerization. design and synthesis of co-receptors and Multiple recognition. UNIT VII . the need of green chemistry. General methods of drug synthesis. UNIT II : Reaction pathways of Organometallic compounds (9 h): Oxidative addition and reductive elimination. Antibiotics.  . Isocyanide. hydroboration and hydroformylation of alkenes. The Wade. electronics. wires. telecommunication. tools of green chemistry. Higher carbonyl clusters. Green reactions . Introduction to Microwave organic synthesis. comparison of the above with classical reactions. different classes of drug. Insertion reactions involving CO. ‘smart materials. mapping of genes.’ Applications to various fields:optics. CO2 and SO2. Biomedical applications: diagnosation. SAR and QSAR. biomimetics. Pencillins. Analgesics (Phenazones and Phenylbutzone as examples). factors governing ability of drugs. Monsanto acetic acid process. nano CAD. Applications: environmental. factors governing drug design. quantum dots. time and energy benefits. digital technology and environment. Green preparations. nanostructures: tubes.Nanomaterials (9 h): Nanocomposites. Oxidative coupling and reductive cleavage. consumer goods.microscopy and electrochemistry. Carbonylation by Collman’s reagent. double. Cannizaro reaction and Grignard reaction. fibers. Applications phase transfer catalysts. drug design. physicochemical factors and biological activities. Nucleophilic additions and abstractions to coordinated legends such as CO. UNIT VIII – Supramolecular Chemistry (9 h): Molecular recognition: Receptors.MingosLauher rules. alkenes.UNIVERSITY OF CALICUT M.single. UNIT III : Catalysis by organometallic complexes (9 h): Alkene hydrogenation. nanostructure formation: lithography. Oligomerization and Polymerization. measurement of nanostructure: spectroscopy. drug delivery. self-assembly. NO. isomerisation.crystal growth and polymerization.Aldol condensation. alkyls and acyls Electrophelic addition and abstraction to alkyl groups. UNIT IV : Medicinal Chemistry (9 h): Drugs: Introduction. drug action. bricks and building blocks. The isolobal analogies cluster structure and electron count. alkynes. Watergas shift reaction.mechanism. 44 .Sc. prodrugs. UNIT V – Green Chemistry (9 h): Introduction. Antipyretic (Paracetamol).molecular synthesis. rational approach to drug design.  eliminations. CHEMISTRY (CSS PATTERN) – SEMESTER IV CH4CO9 Advanced Topics in Chemistry (4 Credits) UNIT I : Metal Clusters (9 h): Metal-metal bonds and metal clusters. polyenes. UNIT VI – Nanoscience and Technology (9 h): Introduction. triple and quadruple bonded non-carbonyl clusters. Chloramphanicol. Hydrogen bonds. Weinheim. G. G. 1999. Gelators fibres and adhesives. 5. Agullo Rueda.K. 1997. 2008. binding of neutral molecules.) and F.A. 3. Nanotechnology for Microelectronics and Optoelectronics. F.H. Murillo and M.N. Blackwell Science.). James Clark and Duncan Macquarrie. Lippincott – Raven Publishers.T. strong. Anastas and J. Bioinorganic Chemistry. 1998. 13.M.J. Jeiping Zhu and Hugues Bienayme (Ed. F. binding of anions. Cation binding hosts. 11. 2002. Supramolecular reactivity and catalysis. weak and very weak H-bonds. Springer Verlag. John Wiley & Sons. Transport processes and carrier design. Introduction to Nanotechnology.). Wilkinson. Cotton. Green Chemistry: Theory and Practice. London. Chichester. Nanochemistry. Warner. KGaA. 2003. catenanes and rotaxanes References 1. 12.C. Arsenault. J.C. Delgado and W. Vögtle. Use of H-bonds in crystal engineering and molecular recognition. Ozin and A. Owens. The Chemistry of Waste Minimization. Martinez Durat. 1998. Dugas (Ed. 1995.A.. Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. 7. 1991. Multi Component Reactions. Supramolecular Chemistry. Wiley VCH Velag GmbH & Co. Wiley. Wiley – VCH. Gringauz. Kapoor. Bochmann. C. Martin Palma and F. 2008.J. Dendrimers. organic solids. organic conductors and organic superconductors. Supramolecular devices. R. Thomas. New York. Advanced Inorganic Chemistry. J. Remers. supramolecular photochemistry. Wiley. C. G.P.A. P. Wiley. RSC Publishing. 2007. 6. binding of organic molecules. 10. A. Chichester. Oxford University Press. Harkishan Singh and V. (Ed. Utilisation of Hbonds to create supramolecular structures. 2. Blackie Academic. 2005. 4. Oxford. Elsevier. 1996. 6th edition. Medicinal and Pharmaceutical Chemistry. 9. 14. 45 . H. Vallabh Prakashan. Novel liquid crystals. Introduction to Medical Chemistry. J. Clark. 8.). Handbook of Green Chemistry and Technology. Fundamentals of Medicinal Chemistry.A. 10th Edition. Poole (Jr. starch based food products and beverages. Unit VII: Analysis of Drugs and Pharmaceuticals (9 Hrs): Modern methods of drug analysis. liquid. (d) Auger Electron Spectroscopy (AES).Organic and Inorganic water quality parameters and standards. HPLC. (d) Thermometric Titratons. high molecular weight amines. Unit V: Separation Techniques ( 9 Hrs): Theory and applications of solvent extraction and ion exchange methods. Unit II: Optical Methods-II (9 Hrs): Theory. column and gas chromatography. Instrumentation and uses of Paper. Analysis of fats and oils.Review of Hartree. (e) Thermo Mechanical Analysis (TMA) and (f) Dialatometric Analysis (DMA). (c) Differential Scanning Calorimetry (DSC). Unit IV: Thermal and Radiochemical Methods (9 Hrs): Theory Instrumentation and Applications of: (a) Thermogrammetric Analysis (TGA). butter. thin layer. CHEMISTRY (CSS PATTERN) SEMESTER IV CH4E04 INSTRUMENTAL METHODS OF ANALYSIS (Elective) (4 Credits) Unit I: Optical Methods-I (9 Hrs): Theory. Theory. Water pollutants. cholesterol and Blood sugar. Instrumentation and Applications of (a) Atomic Absorption Spectrometry (AAS) (b) Atomic Fluorescence Spectrometry (AFS) (c) UV-Visibles IR spectrometry (d) Nephelometry and Turbidometry and (e) Flame Photometry.Fock SCF method. Basis sets STO’s and GTO’s.Sc. dithiocarbamate and crown ethers in extraction. Air quality standards.Principle of estimation of hemoglobin. Instrumentation and Applications of a) Electro grammetry b) Coulometry c) Amperometry d) Cyclic Voltammetry e) Polarography f) Chronopotentiometry and g) Stripping analysis. Uses of oxine. Theory of analysis of milk.Nomenclature of Basis sets.UNIVERSITY OF CALICUT M. dithiazone. Unit VIII: Introduction to Computational Quantum Chemistry (9 Hrs): Electronic structures of molecules. Chromatography. BOD. (c) Ultraviolet Photo Electron Spectrometry (UPES). (b) X-ray Photoelectron Spectrometry (XPES). Semi empirical 46 . COD and TOC determinations.Classification.Iodine value and saponification value – their significance. sampling techniques and monitoring of air pollutants. (e) Scanning Electron Microscopy (SEM) and (f) Scanning Tunnelling Electron Microscopy (STEM) Unit III: Electro Analytical Methods (9 Hrs): Theory. Instrumentation and Applications of (a) X-ray absorption and X-ray diffraction. Unit VI: Environmental Analysis (9 Hrs): Air pollutants. (b) Differential Thermal Analysis (DTA). Environmental Chemistry. 6. Skoog and West. Merrit and Dean. Quantum Chemistry 5th Edn.Jensen.O. References: 1. Pecksock.A fundamental Textbook.C. Shields. Water. Carms and McWilliam. Official Methods of Analysis of the A. 47 .K. Specification of molecular geometry using a) Cartisian coordinates and b) Internal coordinates. 9. I. Wilson. Clinical Chemistry.N.A. 2. The Z-matrix. 7. Comprehensive Analytical Chemistry. Willard. Clane. T. Levin. F. Physical Chemistry. Donaid F Calbreath. 12. 8. Simon. Test book of Quantitative Inorganic Analysis. and methanol.D. D. 5. 10. Principles of Instrument Analysis. Mc Quarrie and J. 3. A Hand Book of Computational Chemistry. Introduction to Computational Chemistry. Instrumental Methods of Analysis. Z matrices of some simple molecules like H2. Modern Methods of Chemical analysis. C. Vogel’s. De. 13. Analytical Chemistry.L. J. ammonia.G. A molecular approach. A. 11. Calculations using Gaussian Programme. Dick. formal dehyde.and ab initio methods.A. 4. Wilson and D.W. effect of choice of method/ basis set (model chemistries) on cpu time. setting up and running a MD simulation. error estimation. generalised gradient approximation. Metropolis method. practical aspects of computer simulation. triple zeta. periodic boundary conditions. Unit III Computer simulation methods II (9 h): Molecular dynamics (MD) method – molecular dynamics using simple models – MD with continuous potentials. Closed shell systems . phase space. hybrid functionals. potential energy surfaces and chemical properties. SCF treatment of polyatomic molecules. UNIT V Density Functional Methods (9 h): Introduction to density matrices. Molda and Molden in analyzing Gaussian output data Identification and visualization of normal modes of vibration . Computable Quantities – structure. Koopmans theorem.Sc. Monte Carlo (MC) method . Monitoring the equilibration. Classification of computational methods.restricted HF calculations. Exchange correlation functionals – Thomas-Fermi-Dirac model.energy. polarization & diffuse basis sets. Chemcraft. software & hardware. Poplestyle basis sets and their nomenclature. pressure and temperature. contracted basis sets. analyzing the results of a simulation. basis set truncation error. split-valence. UNIT VII Introduction to Gaussian 03 Program (9h): Input files – converting a structure from a graphics program – Main features of Gaussian output files – Use of graphics programs like Gaussview. Cost & Efficiency – relative CPU time. Slater-type & Gaussian type basis functions. Local density approximation. heat capacity. classification of basis sets – minimal.UNIVERSITY OF CALICUT M. Need of approximate methods in quantum mechanics.COMPUTATIONAL CHEMISTRY (4 credits) (72 h) Unit I Introduction (9 h): Theory. Hohenberg – Kohn theorems. The Roothan – Hall equations. Unit II Computer simulation methods I (9 h): Introduction – molecular dynamics and Monte Carlo methods.Calculation and interpretation molecular orbitals. choosing the time step. Introduction to electron correlation (post-HF) methods. UNIT IV ab intio methods in computational chemistry (9h): Review of Hartree – Fock method for atoms.calculating properties by integration. Open shell systems – ROHF and UHF calculations. correlation consistent basis sets. Comparison between DFT and HF methods. random number generators. UNIT VI Basis set approximation (9 h): Hydrogen-like. Kohn-Sham orbitals. calculation of simple thermodynamic properties . computation & modeling – Definition of terms. finite difference methods. double zeta. CHEMISTRY – SEMESTER IV CH4EO5 . even tempered & well tempered basis sets. MC simulation of rigid molecules. 48 . N-reprentability & V-represetability problems. HF limit & electron correlation. Frank Jensen. 6th Edition. 2000. Introduction to Computational Chemistry. Koch. David Young. 4. Quantum Chemistry.S. Computational Chemistry. Pearson Education Inc. 3. John Wiley & Sons 2002. Wiley-VCH Verlag 2000. P.locating local minima and saddle points on potential energy surfaces. 2. Essentials of computational Chemistry: Theories and models. J. “A Chemist’s Guide to Density Functional Theory”.. Holthausen. Oxford University Press.A Practical Guide for Applying Techniques to Real-World Problems”.. Friedman. Gaussian Inc. 2005. W. 4th Edition. John Wiley & Sons LTD 1999. the normal mode and IRC analyses. Geometry optimization & Frequency calculations . Further Reading 1.. 2. Molecular quantum mechanics. Springer 2011.N. Wiley-Interscience. 49 . Foresman & Aelieen Frisch. I. M. 2nd edn. Transition state optimizations – characterizing transition states. 2009. Atkins & R. Exploring Chemistry with Electronic Structure Methods. scaling frequencies and zero point energies. Computational Chemistry: Introduction to the theory and applications of molecular quantum mechanics.W. 2001.C. Levine.UNIT VIII Calculations using G03 Program (9 h): Single point energy calculations. Errol G. 5. J. Lewars. C. Reference Text Books 1. 3. Cramer. UNIT III Nanomaterials and nanotechnology (9h): Nano materials. liquid state processing. material design and selection. sol-gel processing & vapor deposition technique. 50 . functional classification. Superconducting materials . polyether ketones. Engineering plastics such as polyacetyl. sol-gel process. soft.Sc. theories of superconductivity. environmental and other effects. Gelation network . ferri and ferro magnetism. UNIT VI – Some special polymers (9h): Functional polymers photoconductive. Mechanical properties – significance and terminology. porous solids. electrical. Composites with metallic matrices – processing. use of phase diagrams in predicting material behaviour. Ceramic magnets. CHEMISTRY (CSS PATTERN) – SEMESTER IV CH4E 06 . applications. solid and liquid state processing. Nano particles . polycarbonate. catalysts. UNIT VII – Composite Materials (9h): Definition and classification of composites.production. nano structures. hard & superconducting magnets. PE. atomic interactions and types of bonds. UF & MF. true stress and true strain. classification based on structure. electrokinetic potential and peptization reactions. applications of sol-gel process. PBT).structure and applications. magnetic. properties and applications. Chemical modification of nano surfaces. self assembly. mixing & Pressing. Ceramic matrix composite materials – processing. precipitation. one component and multi component systems. vacuum distillation and electro refining. Meissner effect. & PS. Commodity plastics such as PP. PVC.methods of synthesis. polyacrylate. Metallic glasses . theory of ferroelectricity. piezoelectric materials and applications. dispersions and powders. the tensile test. classification of materials. Thermosetting plastics such as PF.UNIVERSITY OF CALICUT M. bend test. properties. hardness of materials. metallic magnets. polyester (PET. classification of ferroelectric materials. High temperature superconductors .preparation. piezoelectric and light sensitive polymers. phase equilibria in ceramic systems. polyamide (nylon 6 and nylon 66). Industrial polymers . UNIT V – Materials for special purposes – II (9h): Magnetic materials. aerogels. hydrolysis of salts and alkoxides. & compounding of industrial polymers. and optical properties of ceramic materials. sol-gel coating. traditional and new ceramics. electroconductive. ferroelectric domains. drying of gels. UNIT IV Materials for special purposes – I (9h): Production of ultra pure materials . fibres and matrices.MATERIAL SCIENCE (4 credits) (72 h) UNIT I Introduction to Material Science (9h): Introduction. structure of ceramics.general properties. deposition.metallic and ceramic superconducting materials.xerogels. condensation reactions. low conducting and superconducting magnets.zone refining. Ferroelectric and piezoelectric materials . UNIT II Ceramic materials (9h): Definition of ceramics. Tinkham. McGraw Hill. 1987. Co. 9.Interfaces in composites .mechanical & microstructural characteristics. glasses & composites .V. S. UNIT VIII – Fracture Mechanics (9h): Importance of fracture mechanics. 13. ceramics.K. Azaroff and Brophy. Polymer Science. Composite Materials. evaluation of creep behavior.S. Uhlman.. A. Essentials of Material Science. A. K. V. Wiley Eastern Ltd. Applications of composites. 1985. Eingery.G. John Wiley.. 1975. Dowen and R. 15. application of fatigue testing . McGraw Hill. Hajra Choudhary.J.R. 5. 12.J. 2. Science of Engineering Materials. R. South Asian Publishers. Hansen Publishers. 1983.creep. H. S. Longman Scientific and Tech.M. Springer-Verlag. Introduction to Superconductivity. M. McGraw Hill. Indian Book Dist. High Temperature Superconductors. 11. John Wiley and Sons.W. Guy.V. Superconductivity and Superconducting Materials. Weibull statistics for failure. Introductory Material Science. Ulrich. Subramanyan and E. stress rupture & stress behavior. 1997. NY. Rajagopal. Wiley Eastern Ltd. C. Introduction to Industrial Polymers. 4. Young. Fatigue.D.Edbote. 8. Introduction to Polymer Science.D. Chowla. Starfield and Shrager. Barsoum. micro structural features of fracture in metals. M. 1982. 1987.K. Material Science and Engineering. Handbook of Polymer Fibre Composites. 1. Srinivasan. Fundamentals of Ceramics. strength analysis. Srivastava and C.R. 1988. 10. References W. 6. H. Electronic Processes in Materials. Gowriker and Others. Narlikar and S. 3. Calcutta. F. McGraw Hill.. M. 14. Jones. Wiley Eastern Ltd.N.K. Introduction to Ceramics. 7. 51 . New Delhi. McGraw Hill. hemoglobin and myoglobin. N2 and Oxygen. ammonia synthesis. metal complexes used for diagnosis and chemotherapy. Copper enzymes.Formation structure. zeolite based heterogeneous catalysis catalytic applications involving palladium. Substitution reactions in carbonyl complexes. Hydroformylation of alkenes. bonding and reactions.nucleophilic and electrophilic attack on coordinated legands.oxidative addition. superoxide dismutase vitamin B12 and Coenzyme. Metal deficiency and diseases. Unit V (9 h): General characteristics of organometallic complexes.reductive elimination and insertion reactions. Monsanto acetic acid process. NitrogenasesBiological nitrogen fixation. 52 . CHEMISTRY (CCS PATTERN) SEMESTER IV CH4EO8 BIOINORGANIC AND ORGANOMETALLIC CHEMISTRY (Elective) (4 Credits) Unit I: Bioinorganic Chemistry-I (9 h): Coordination sites in biologically important ligands. Iron enzymes. toxic effects of metals. Unit VII (9 h): Catalysis. Non heme oxygen carriers. other nitrogenases. theoretical aspects of 16 and 18 electro rules. glucose storage. Sodium pump and active transport. model systems. Role of alkali metal ions in biological systems. Transition metal complexes of H2. Lewis acid. Unit IV: Bioinorganic Chemistry IV (9 h): Bioenergetics and ATP cycle.cytochrome P-450. Redox enzymes. Unit VIII: Heterogeneous catalysts: Ziegler Natta Catalysis. heterogeneous reactions. Unit VI (9 h): Applications of organometallic compounds in Organic synthesis an catagysis. carbonylation by Collmann’s reagent.Sc.UNIVERSITY OF CALICUT M. Electronic and geometrical structures of metal ions in biology. Anticancer drugs. asymmetric hydrogenation cycloadditions and polymerization of alkynes.Oxidase. Unit III: Bioinorganic Chemistry III (9 h): Transport of oxygen by Heme proteins. Role of Zn (II) and Mg (II) containing enzymes. Thermodynamic and kinetic aspects of stability. catalytic steps. Wacker process. catalase. Ionophores and passive transport. chlorophyll photosystem I and II. Structure and function of proteins in electron transport process. Nomenclature. peroxidase. cytochromes and iron sulphur proteins. classification. general principles. SO2 oxidation. homogeneous and Homogeneous catalysis: Hydrogenation of alkenes. Unit II: Bioinorganic Chemistry II (9 h): Metallo enzymes and electron carrier metallo proteins. hemerythrin hemocyanin and hemovanadins. P. Shriver. Inorganic Chemistry. Oxford University Press. 6. Kerter and R. Harry B Gray. Fenton. S. Organometallic Chemistry a unified approach. 2nd Edition. Wilkinson. Oxford. R. Biocoordination Chemistry. 1991. 4. Lippard and Joan Selverstone. Singh. 1988. J. Mehrothra and A. ELBS.L.E. Ellis Horwoord.A Murillo and M.F. Stephen. E. 1997. 1994. Principles of Organometallic Chemistry.L. 2. P. Cotton and G. Hay. Advanced Inorganic Chemistry. D.E. 9. 5. 2001. Keiter. Lippard and J. University Science Books.M. Wiley Eastern. J.H. 1984.C.A.W. D. R. ELBS. 1995. 3. John Wiley & Sons. Powell. Langford. Valentine. C. F. Principles Structure and Reactivity. Bochmann. Ivam Bertini.W. 7. Berry. 1999. University Science Books. 8. 53 . Inorganic Chemistry.References: 1. Principles of Bioinorganic Chemistry. ‘Bioinorganic Chemistry’.A. Bioinorganic Chemistry. 1990. Pearson. Atkins and C. Huheey. California. Estimation involving quantitative separation of suitable binary mixtures of ions in solution (Cu2+. Experimental Inorganic Chemistry. (5 Nos) 2. Nl2+. D.A. 2. References: 1. Cu. 4.B.Palmer. W.G. Mg2+. Preparation of Inorganic Complexes.M. Colorimetric estimation of Ni. Quantitative Chemical Analysis. Ion. 3. Brauer. Adams and J. 54 . G. Vogel’s Text Book of Qualitative Inorganic Analysis. CHEMISTRY (CSS PATTERN) SEMESTER III & IV CH3PO4 and CH4PO4 – INORGANIC CHEMISTRY PRACTICALS II (4 Credits) 1. I.exchange separation and estimation of binary mixtures (Co2+ & Nl2+. Kolthoff and E. Zn2+ & Mg2+ Hardness of water). Ba2+ and Cr2O12-) by volumetric colorimetric or gravimetric methods only one of the components to be estimated. Fe and Mo after separation from other ions in solution by solvent extraction. 3. Advanced Practical Inorganic Chemistry. Fe3+. 5.A.Sc. Zn2+. Sanderson. 4. Ca2+.UNIVERSITY OF CALICUT M. Rayner. Hand book of Preparative Inorganic Chemistry. iodine value and saponification value of oils and fats (at least one each). Brilliant Blue. Tatrazine. CH4PO5 – ORGANIC CHEMISTRY (4 CREDITS) UNIT I : Quantitative Organic Analysis Estimation of equivalent weight of acids by Silver Salt method. Orange II. E. UNIT III : Practical application of PC and TLC. Malachite green. susnet yellow. Terpinoids. Stroptomycin. Hannaford. Chlorophill Steroids. Identification by using spray reagents and co-chromatography by authentic samples and also from Rf values. UNIT II : Extraction of Natural products and purification by column chromatography and TLC – Caffeine from Tea waste. Hydroquinone. Artificial sweeteners: Saccharine. Sudan II. Preparation of TLC plates. Amino acids (Protein Flavonoids. Drugs – sulpha drug (Sulpha diazine. CHEMISTRY (CSS PATTERN) SEMESTER III & IV CH3PO5. TLC and LC analysis of pesticides of international importance. 2. VI & VII. citral from lemon glass (steam distillation). J. non Nostrand Reinhold Company.UNIVERSITY OF CALICUT M. A.G. Smith and A.S. Zwig. Antibiotics – Pencillin.R. Academic Press. Tatchell. Chromatography. Pharmacuetical Analysi. ELBS/Longman. Metanil yellow. B. Identification of the following classes of compounds using one. Casein from milk. Colourimetric estimations: Vitamins (Ascorbic acid). Fast green. Estimation of reducing sugars. Activation. ethyl acetate antioxidants: Butylated hydroxytoluene (BHT) Butylated hydroxy anisole (BHA). Beebet.and two-dimensional techniques. Congo red. Alkaloids. Vol. Estimation of amino group. Flavour adulterants – piperonal. P. Nonpermitted colours: Auramine. 1989. Dulcin. Pesticides and herbicides: Oragonochlorine pesticides organo phosphates and carbamate posticides. Vogel's Textbook of Practical Organic Chemistry. Sugars. Congo red. Steroids. Furnis. Food additives and Dyes. phenolic group and esters.W. Benzalacetate. Plant growth stimulants: Indolacetic acid. cyclamates. Sherma and G. Herbicides. Determination of Acid value. Flavonoid (Soxhlet extraction).J. hydrolysates). References 1. 2. Food colours: Permitted – Amaranth. Erythrosine.Sc. sulphaguanidine). References 1. Hoftmann. 1975. New York. Estimation of nitrogen by Kjeldahl method. 55 . Bladt. H. S. Tokyo. Plant Drug Analysis.M. Wagner. Zgainsti – Tram. 1984. Th. A. Scott. Springer-Verlag.. E.3. 56 . benzene) 57 . succinic acid. 3. (a) Determination of phase diagram of a ternary liquid system (e. Determination of surface area of adsorbent.g. Determination of cyroscopic constant of a liquid (water.g. KCl. Determination of specific reaction rate of saponification of ethyl acetate.g.g. (b) Determination of the composition of a binary liquid mixture (e. Determination of specific reaction rate of acid hydrolysis of an ester (methyl acetate or ethyl acetate) and concentration of the given acids. Iodination of acetone in acid medium – Determination of order of reaction with respect of iodine and acetone. benzene-acetic acid) 2. UNIT II Adsorption (3 experiments) 1. UNIT III Phase Equilibria (2 experiments) 1. 4. chloroform-acetic acid. NaCl.. phenol – water) and critical solution temperature (CST). CHEMISTRY (III & IV Semesters) CH3PO6. Determination of Arrhenius parameters of acid hydrolysis of an ester. Verification of Langmuir adsorption isothem – charcoal-oxalic acid system. Determiantion of the concentration of a given acetic acid solution using the isotherm 2. UNIT IV Cryoscopy – Beckman thermometer method (3 experiments) 1.Sc.g.. CH4PO6 – PHYSICAL CHEMISTRY PRACTICAL II (4 credits) UNIT I : Chemical Kinetics (4 experiments) 1. (a) Determination of mutual miscibility curve of a binary liquid system (e.. salicylic acid) on the CST of water-phenol system) (c) Effect of a given impurity (e. Determination of the concentration of a given acetic acid solution using the isothem.UNIVERSITY OF CALICUT M. (b) Effect of impurities (e. Verification of Langmuir adsorption isotherm – charcoal-acetic acid system. 3. chloroform – acetic acid – water – Benzene – acetic acid – water) (36 LS) 2.. KCl) on the CST of water-phenol system and determination of the concentration of the given solution of KCl. Determination of concentration of HCl UNIT VI Spectrophotometry (3 experiments) 1.A. fructose and sucrose. 1965. Advanced Practical Physical Chemistry. 1961. Garland.A. K2Hgl4 and determination of the UNIT V Polarimetry ( 3 experiments) 1. Daniels and J. glucose. Goel Publications. Affiliated East-West Press Pvt.A. cane sugar.L. Churchil Ltd.2.H. Study of the reaction 2Kl + Hgl2  concentration of the given Kl solution. Finlay and J. Determination of specific rate of inversion of cane sugar in presence of HCl.P. 5. 4. Practical Physical Chemistry. 4. Instrumental Methods of Analysis.. Determination of specific and molar optical rotations of glucose. 6. Practical Physical Chemistry.H. 2. Determination of molecular mass of a soute (urea. 1989. Simultaneous of determination Mn and Cr in a solution of KMnO4 and K2Ce2O7 Investigation of complex formation between Fe (III) and thiocyanate. Dean. Yadav. Determination of equilibrium constants of acid-base indicators. Merit and J. benzene) Determination of Van't Hoff factor and percentage of dissociation NaCl. D.B. McGraw Hill.. 2. J. Longman. J. H. 3. L. Shoemaker and C. A. 3. 58 . F. Experimental Physical Chemistry. 2. Ltd. of 3. Reference 1. 3.H. Kitchener. mannitol) by studying the depression in freezing point of a liquid solvent (water. Longman. 4th Education. Experimental Physical Chemistry. A.W. James. Mathews. Willard. Vine. Determination of half life & average life of a radioactive element. C. Programming in C. 6.SECTION B UNIT VII Computer Applications in Chemistry(8 experiments) (The experiment consist of writing a computer programme in C language for a problem of chemical interest and its execution using a computer. John Wiley and sons. P. NY. Personal Computers in Chemistry. 59 . 7. 1981. Benjamin Inc. 2007. Determination of solubility of sparingly soluble salts. John Wiley and Sons. Each student is required to answer two questions. E. Thompson Course Technology. Each student in a batch shall be given separate questions. Raman. 10. 4. Balaguruswamy.. 2. g particle confined in a one-dimensional box of length 100nm at room temperature (E = n2h2/8ma2 = kT/2). QUESTION PAPER 1. Calculation of delocalization energy. one based on one or more units in Section A (60 marks) and the other from Section B (20 marks) 2. Macmillan India Ltd. (Necessary adsorption data are provided) Reference 1. Wiberg. Comparison of the translational quantum numbers of i) an electron ii) helium atom iii) carobon-60 and iv) a 1.Lykose. Determination of Arrhenius parameters of acid hydrolysis of methyl acetate by the method of least squares by writing a C programme (Necessary kinetic data are provided). Determination of lattice energy of ionic crystals musing Born Lande equation. NY. Programming. 2004. 1991. 4.B.V. Verification of Langmuir and Freundlisch adsorption isothems by the method of least square by writing a C programme and determination of adsorption parameters. 3. The student shall generate a hard copy of the programme and the results using a printer for submission) 1. Tata McGraw Hill. Computer in Chemistry. Programming for the Absolute Beginner. A. 6. Determination of first ten energy levels of i) an electron ii) a helium atom iii) carbon 60 and iv) a particle of mass  g confined in a onedimensional box of length 100nm and comparison of energy spacing of these systems. 2. 5. 5. Determination of molecular weight of an organic compound. Dan Gookin. 1965. C. Michael. Calculation of dipole moments of disubsituted benzenes. 9. 3. 1993. K. Computer Programming for Chemists. 8. K.