Semester Wise Lay out of Course of M.Sc Radiation and Medical Oncology Semester No First Semester Course Number MS- 510 Ms-521 MS- 522 MS-523 MS-524 MS-525 CMS-501 Course Title Introduction to Nuclear Technology Principles of Radiotherapy and Cancer Chemotherapy Mathematical Modeling of Biological Systems and Epidemiology Radiation Detection, Protection and Instrumentation Tumor and Radiation Biology Diagnostics of Cancer Communication Skills Credits NC +IR 3 3 3 3 3 Second semester MS-527 MS-611 MS-612 MS-613 MS-614 Radiation & Medical Oncology Laboratory Treatment Planning in radiation Oncology Pathophysiology of Tumors Management and Treatment of Individual Cancers Advanced Therapeutics in Oncology 3 3 3 3 3 3 Third Semester MS-697 Thesis Project 10 Fourth Semester MS-691 Intensive Clinical Training in radiation and Medical Oncology I 10 Fifth Semester Ms-692 Intensive Clinical Training in radiation and Medical Oncology II 10 Biological therapies. Linear accelerator physics. Analgesia in cancer patients. Modern radiation therapy comprising of three dimensional conformal therapy. Total body irradiation. Steroids and anti-emetics. Unusual toxicities-veno-occulusive. protection strategies. rationale. Principles of high dose therapy. Pharmacokinetics and pharmacodynamics of chemotherapeutic agents. Toxicity of chemotherapy. Physics of brachytherapy. Poisson and Gaussian distribution. hormone therapy. Standard deviation. Stereo tactic radio surgery. Present status of nuclear power in Pakistan and in the world. Harmonic analysis and Fourier series & transform. Cooperation between physicist and physician. Chi-square test. Drug design and development. Review of nuclear reactors and fuel cycle facilities. Principle of clinical use of chemotherapeutic agents. Development of nuclear technology. Applications of statistical analysis. Biological and novel therapies. Current problems and future prospects of nuclear power. MS-522: Mathematical Modelling Of Biological Systems And Epidemiology Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Differentiation and integration. . First order and second order differential equations. Heavy particle physics.Detailed Course Contents MS. MS-521: Principles of Radiotherapy and Cancer Chemotherapy Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Use of ionizing radiation in radiotherapy. Basic principles and use in cancer therapy. Target therapy. concept of vaccination in cancers. Team work approach. Significance of statistics in medicine. Drug interaction in cancer treatment. IMRT. Colony stimulating factors. Growth factors .510 Introduction to Nuclear Technology Compulsory Credits Prerequisite Institutional Requirement Nil Nil Course Format One hour of lecture per week Developments in physics leading to the discovery of nuclear fission. Classification of chemotherapeutic agents. Teletherapy. Mode of action of cytotoxic drugs. Radiopharmaceuticals. Interferons. Electron beam physics. Radiation protection standards. Statistical criteria for the selection and adjustment of counters. Genetics of normal and malignant cells. Trends in cancer incidence and mortality for major cancers . Transfection. Various types of dosimeters. MS-523: Radiation Detection. CT simulators MS-524: Tumour and Radiation Biology Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Introduction. Principles and use of techniques. Various types of detectors. Principles of radiation detectors and their common properties. Principles of sample size calculation. Micro array techniques. Nuclear regulatory commission regulations. Clinical trials and ethics. Blotting. Radioactive waste management in hospitals. Cell survival curves. Interaction between radiation and other agents. Basic principles for control of external and internal exposures and absorbed dose estimation. Radiation spectroscopy. Co 60. Cancer registration and follow-up. General principles of tumour biology. Normal tissue radiobiology. General principles of radiobiology. Health Physics instrumentation and personal dosimetry. Simulators. Factors modifying the effect of radiation at the cellular levels. Population radiation biology. Normal tissue damage and tolerance. Dose calibrator. Chemotherapy. .Concepts of probability. Protection against radiation from brachytherapy sources. The cellular mechanism of cancer including mechanisms for apoptosis and cellular immortality. Protection and Instrumentation Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Basic concepts of radioactivity. 4 R's of radiobiology used in radiotherapy. Oncogenes triggers. Sequencing. Quality control and quality assurance of radiotherapy instrumentation. Early medical treatment of radiation injuries. Electrophoresis. Linear accelerator. Techniques in molecular biology. Basic concept of dosimetry. The expression and consequences of oncogenes. Collimation of radiation. Mortality rates and standardized mortality rates. Cell. Tests of significance. molecular biology of radiation damage and repair. Hyperthermia. Nuclear electronics. Causation of human cancers. Effect of radiation at cellular level. Normal and aberrant mechanisms of cell growth control. Role and basic principles of meta-analysis. Survival analysis. Odds ratios and relative risks. PCR. Transgenic models. Mammography technique. 4. Characteristics of scintillation detectors and determination of pulse height spectra of gamma sources. Radiological anatomy. Measurement of half-lives of a single and a mixture of radio nuclides. Verification of counting statistics. . Basics of CT. a minimum of 10 experiments are to be performed. B & M Mode. 3. Characteristics of Ge (Li). dead time measurement. A. Hyperthermia. Nuclear medicine procedures and radiopharmaceuticals used in the diagnosis and follow-up of different tumours. Conventional X-Ray. dose and fractionation in Radiotherapy.tissue and tumour kinetics. Time. Alternative radiation modalities. Radiation Detection and Measurement: 1. Health Physics 1. and beta attenuation. PET/CT in oncology. tube. Principles of ultrasound. Gene therapy. MS-525: Diagnostics of Cancer Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Imaging modalities/procedures and technology. MS-527: Radiation & Medical Oncology Laboratory Compulsory Credits Prerequisite C 3 Nil Course Format Nine hours of laboratory work per week Out of the experiments listed below. Mammographic signs of breast cancer and mammographic features of benign and malignant disease.M. Calibration and use of survey meters. 2. HPGe or Si (Li) detector and its use in gamma ray spectroscopy. Characteristics of a G. CT imaging of different tumours. Determination of attenuation coefficient and build-up factor of gamma rays for different shielding materials. Measurement of Co-60 source strength using gamma-gamma or beta-gamma coincidence method. MRI in Oncology. Contrast media. 6. 5. Specialized techniques of cancer diagnosis. 7. Predictive assay. Characteristic growth and Metastatic pattern. Paraneoplastic syndromes. Brachytherapy. MS-612 Pathophysiology of Tumours Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Anatomical sites and types of tumours. Field shaping. The natural history of the disease including likely presentation. Treatment planning by computer. Treatment Planning. Calibration of TLD system and measurement of unknown dose. Use of wedge filters. Staging classifications. incidence and morphology of common tumours. specialised multidisciplinary approach to patient management. Immunocytochemistry. lsocentric technique. ICRU volumes. MS-611: Treatment Planning In Radiation Oncology Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Treatment planning. Teletherapy. Combination of Radiation fields. Verification port films. FIGO. Contamination survey and decontamination procedures. Routine operational tests for radiotherapy instruments. 2. etiology. Use of specialised pathology techniques. bolus & tissue compensator. Tumour and normal tissue dose computation by manual & computerized techniques. staging protocols. Classification and spread. g. Simulation 3. Corrections and setup. 5. Verification of inverse square law and source strength measurement. Use of tumour markers in diagnosis and treatment of tumours. Electron beam therapy. 4.2. Skin dose and field separation. Interpretation of clinicopathological data in the tumour site. 3. Clinical Laboratory 1. . Design and use of simulators. Treatment planning for implant therapy. Quality control tests for radiotherapy instruments. Treatment planning and its implementation. General principles of data processing. e. TNM. 4. Iso dose distribution. Patient data. Mould room practical work. Cancers of unknown primary site. Assessment of pain. Inhibition of genetic expression. Risk of second cancer. Organ and system failures. Cancer cachexia. Cancers of gastrointestinal tract. Specialized care for terminally ill patient. Combination therapy. Risk counselling. Cancer of the skin. Cancer of the endocrine system. Therapeutic strategies. Cancer pain palliation. splintage. Benign and malignant mesothelioma. Infection treatment strategies. Concepts and implication. Molecular radiotherapy. Supportive care for cancer patients. Cancer of the testis. Immunological stress in cancer patients. Evaluation of febrile patient in cancer ward and management. Impaired host defences and common pathogens in cancer patients. Cancer pain neurophysiology and biochemistry. Aids related malignancies. Cancer of the lung. Cancers of childhood. Psychiatric and psychological disorders in cancer patients. Gene Therapy. Components of genetic counselling session. Neoplasm of mediastinum. Treatment of Metastatic cancer. Nutritional support. MS-691: Intensive Clinical Training in Radiation & Medical Oncology 1 Compulsory Credits C 10 . Neoplasms of the central nervous system. Infection in cancer patient. Psychological issues. Acute and late complications of cancer and their management. Physical measures (bed sores. Sarcomas of the soft tissues and bone. Gynaecologic cancers. Cancer of the genitourinary system. Special condition to reduce toxicity of chemotherapy. Lymphomas.MS-613: Management and Treatment of Individual Cancers Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Cancers of the head and neck. Leukaemias. Approaches to meet needs of dying patient. massage etc). Chemotherapy protectors. Prevention of infection in cancer patient. Newer approaches in cancer treatment. Genetic counselling. Immunotoxins and anti angiogenic modes for cancer management. Cancers of the breast. Radiotherapy for benign diseases. Malignant melanoma. MS-614 Advanced Therapeutics in Oncology Compulsory Credits Prerequisite Course Format C 3 Nil Three hours of lectures per week Oncological emergencies. Consequences and management. and aspiration of fluids have to be carried out and recorded in the log book. It is of sufficient breadth to ensure that student is thoroughly acquainted with the techniques and methods of major diagnostic and therapeutic applications. The training program is designed to give fellows ample opportunity to attain competence in correlating the patients' problems with optimum selection of the therapy regime. In .. Fellows have to take histories. Basic procedures including nasogastric intubations. MS-697: Thesis Project Compulsory Credits Prerequisite Course Format C 10 Nil Minimum of 30 hours of research work per week (Duration 14 weeks) Students will be attached with a Medical Centre. each student is attached to a specialist at a medical centre. Shaukat Khanum Memorial Cancer Hospital etc. advise suitable investigations. They have to do simulation and brachytherapy along with handling Co-60 & LINAC. The expert there will be responsible for providing guidance and supervision in clinical procedures. planning and therapeutics are covered. catheterization. oncology centres of the Armed Forces. MS-692: Intensive Clinical Training in Radiation & Medical Oncology 2 Compulsory Credits Prerequisite Course Format C 10 Nil Minimum of 30 hours of clinical work per week (Duration 18 weeks) During this semester students will again be attached to different Medical Centres of PAEC as well as with other radiation and oncology centres. which term includes all PAEC Medical Centres with radiation cancer treatment facility. Log book containing 50 cases including both of chemotherapy administration and radiotherapy (not just of chemotherapy administration).Prerequisite Course Format Nil Minimum of 30 hours of clinical work per week (18 weeks) For clinical training. formulate differential diagnosis and reach final diagnosis and devise management plan in consultation with supervisor. oncology centres of the Armed Forces. which term includes all PAEC Medical Centres with radiation cancer treatment facility. in Pakistan for work on their respective research/thesis project. do physical examination. During this phase major aspects of general radiation treatment. Shaukat Khanum Memorial Cancer Hospital etc. completion of assigned tasks and discussions .501 Communication Skills Compulsory Credits Prerequisite Course Format C 1 Nil 1 hour of lecture per week Writing Module: Preparation of a project proposal or technical report. The aim of the project is to train the students in planning and conducting research projects and writing scientific papers. instrumentation. CMS. At the end. This project does not necessarily have to be a completely original study but should exhibit a thorough knowledge of the subject and should be an exhaustive review of the literature on that particular topic. Speaking Module: Presentation of the project proposal or technical report. Writing letters. The purpose of the project is to acquaint the student with the techniques of research in radiation and medical oncology. The area covered by the project should include nuclear physics. Mission statements. Reading Module: Reading of a suitable fiction novel (approximately 30-50 pages a week) with the use of vocabulary support. etc. lectures and question-answer sessions. each Fellow arranges a clinical project for the MS thesis. statistics. Listening Module: Simulations of interviews. dosimetry. each student has to submit a research project report.collaboration with a project supervisor. Office memos etc.
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