M Sc Bangalore University Syllabus

BANGALOREUNIVERSITY M. Sc. Chemistry Syllabus (w.e.f. 2010-2011) 1 DEPARTMENT OF CHEMISTRY SYLLABUS 2010-11 1. Name of the Course : 2. Duration of the Course : 3. Eligibility : M.Sc., Chemistry Two Years (FOUR SEMESTERS) A candidate must have secured 40% marks in the aggregate and studied Chemistry (cognate subject) securing 50% marks in this subject at the B Sc., level and studied Mathematics at 10 + 2 or Pre-university level. 60 + Supernumerary seats + Payment seats As per University regulations 4. Intake 5. Admission : : Scheme of Study and Examination M. Sc., CHEMISTRY First Semester Theory/ Practical (HRS/ Week) Total No.of Hrs/ Semester Duration of Exam. Hours Continuous Evaluation Maximum Marks (Exam) Code No. Total Marks Title C-101 C-102 C-103 C-104 C-105 C-106 Inorganic Chemistry I Organic Chemistry I 4 4 4 4 9 9 52 52 52 52 140 140 3 3 3 3 6 6 80 80 80 80 40 40 20 20 20 20 10 10 100 100 100 100 50 50 500 Physical Chemistry I Analytical Chemistry & Mathematics for Chemists Inorg/Org/Phy Inorg/Org/Phy 2 Second Semester Maximum Marks (Exam) Total No.of Hrs/ Semester Duration of Exam. Hours Theory/ Practical (HRS/ Week) Continuous Evaluation Code No. Total Marks Title C-201 C-202 C-203 C-204 C-205 C-206 Inorganic Chemistry-II Organic Chemistry-II Physical Chemistry-II Spectroscopy-I Inorg/Org/Phy Inorg/Org/Phy 4 4 4 4 9 9 52 52 52 52 140 140 3 3 3 3 6 6 80 80 80 80 40 40 20 20 20 20 10 10 100 100 100 100 50 50 500 Scheme for continuous evaluation Theory (each paper) Attendance : 5 marks Tests* : 15 marks Total : 20 Marks * Two tests will be conducted and the average marks of the two tests will be taken for Continuous assessment. Practicals: (each practicals) Attendance : 2 marks Records : 3 marks Tests : 5 marks Total : 10 marks M. Sc., Chemistry III & IV SEMESTERS (After 2 semester study tour-cum-industrial visits are proposed in and around Bangalore/Karnataka for the students of 3rd/4th semester) nd Scheme of continuous evaluation for all specialisation Theory (each paper) Attendance : 5 marks Tests (2) : 15 marks Total : 20 Marks Practicals: (each practical) Attendance : 2 marks Records : 3 marks Tests : 5 marks Total : 10 marks 3 C 403 Chemistry of Materials C 404 Spectroscopy – III C 405-AC Analytical practical – III C 4 06-AC Analytical practical –IV Total marks for the semester 4 4 4 4 9 9 3 3 3 3 6 6 80 80 80 80 40* 40# 20 20 20 20 10 10 100 100 100 100 50 50 500 * 30 marks (for practicals) + 10 marks (Viva-voce) # 20 makrs (for practicals) + 20 marks (project work based on Experiments in particular specialization. Max.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C 401-AC Instrumental Methods of Analysis C 402-AC Environmental & Biochemical Analysis. Max. Chemistry (Analytical Chemistry Specialisation) III Semester Teaching/conta ct hrs/week Examination Hrs. (Existing C-402) (approved) C-302-AC Reaction Mechanism Catalysis and Organometallic Chemistry C-303 Advanced Analytical Techniques C-304 Spectroscopy-II C-305-AC Analytical Chemistry Practicals-I C-306-AC Analytical Chemistry Practicals-II Total marks for the semester 4 3 80 20 100 4 4 4 9 9 3 3 3 6 6 80 80 80 40 40 20 20 20 10 10 100 100 100 50 50 500 IV Semester Teaching/conta ct hrs/week Examination Hrs. 4 .Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-301-AC Principles of Chemical Analysis. Sc.M. Chemistry (Inorganic Specialisation) III Semester Teaching/conta ct hrs/week Examination Hrs.II C-305-IC Inorganic Chemistry Practicals-I C-306-IC Inorganic Chemistry Practicals-II Total Marks for the semester 4 & 4 4 4 9 9 3 3 3 3 6 6 80 80 80 80 40 40 20 20 20 20 10 10 100 100 100 100 50 50 500 IV Semester Teaching/conta ct hrs/week Examination Hrs. 5 .M.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-301-IC C-302-IC Solid State Chemistry Inorganic Reaction Mechanisms Bioinorganic Chemistry C-303 Nuclear Chemistry OR Advanced Analytical Techniques C-304 Spectroscopy . Max. Max.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-401-IC C-402-IC Organometallic Chemistry Homogeneous and Heterogeneous Catalysis C-403 Photoinorganic Chemistry OR Chemistry of Materials C-404 Spectroscopy-III C-405-IC Inorganic Chemistry Practicals-III C-406-IC Inorganic Chemistry Practicals-IV Total Marks for the semester 4 4 4 4 9 9 3 3 3 3 6 6 80 80 80 80 40* 40# 20 20 20 20 10 10 100 100 100 100 50 50 500 * 30 marks (for practicals) + 10 marks (Viva-voce) # 20 marks (for practicals) + 20 marks (project work based on Experiments in particular specialization. Sc. Sc. Max. Max.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-301-OC Organic Reaction Mechanisms C-302-OC Organic Synthesis-I C-303-OC Chemistry of Natural Products C-304 Spectroscopy-II C-305-OC Organic Chemistry Practical -I C-306-OC Organic Chemistry Practical -II Total Marks for the semester 4 4 4 4 9 9 3 3 3 3 6 6 80 80 80 80 40 40 20 20 20 20 10 10 100 100 100 100 50 50 500 IV Semester Teaching/conta ct hrs/week Examination Hrs.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-401-OC Organometallic and Heterocyclic Chemistry C-402-OC Stereochemistry & Retrosynthetic Analysis C-403-OC Organic Synthesis-II C-404-OC Medicinal Organic Chemistry C-405-OC Organic Chemistry Practical-III C-406-OC Organic Chemistry Practical-IV Total Marks for the semester 4 3 80 20 100 4 4 4 9 9 3 3 3 6 6 80 80 80 40* 40# 20 20 20 10 10 100 100 100 50 50 500 * 30 marks (for practical) + 10 marks (Viva-voce) # 20 marks (for practical) + 20 marks (project work based on Experiments) 6 .M. Chemistry (Organic Specialisation) III Semester Teaching/conta ct hrs/week Examination Hrs. M. Max.Sc.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-301-PC Chemistry of Solids & Diffraction Techniques C-302-PC Photochemistry C-303-PC Quantum Chemistry & Surface chemistry OR Physical Organic Chemistry C-304 Spectroscopy-II C-305-PC Physical Chemistry Practicals-I C-306-PC Physical Chemistry Practicals-II Total Marks for the semester 4 4 4 3 3 3 80 80 80 20 20 20 100 100 100 4 9 9 3 6 6 80 40 40 20 10 10 100 50 50 500 IV Semester Teaching/conta ct hrs/week Examination Hrs. Max.Marks Continuous Evaluation Title of the Paper (Syllabus hours for each theory paper: 52) Total Marks Code C-401-PC C-402-PC C-403-PC Applied Electrochemistry Physical Chemistry of Macromolecules OR Nanomaterials Kinetics and Reaction Mechanism 4 4 3 3 80 80 20 20 100 100 4 C-404 Spectroscopy-III C-405-PC Physical Chemistry Practicals-III C-406-PC Physical Chemistry Practicals-IV Total Marks for the semester 4 9 9 3 3 6 6 80 80 40* 40# 20 20 10 10 100 100 50 50 500 * 30 marks (for practical) + 10 marks (Viva-voce) # 20 marks (for practical) + 20 marks (project work based on Experiments) 7 . Chemistry (Physical Specialisation) III Semester Teaching/conta ct hrs/week Examination Hrs. Lattice energy. 5. P. HSAB concept. Concise Inorganic Chemistry. H. 10hs B. N. ELBS (Oxford Uni. Advanced Inorganic Chemistry 3rd. Press) (1994). 8. Nuclear stability. M. Review of Bronsted and Lewis acids and bases. G. Wilkinson and P.Press (1998).Langford. A. MO Theory: σ. Wilkinson. . zeolites and molecular sieves. Essentials of Nuclear Chemistry. coordinate. properties. 2nd Edition. F. borazines. 5th and 6th Editions. G. W. Inorganic Chemistry. F. J. Greenwood and A. noble gas compounds. P. agostic bond. Bonds: covalent. Arnikar. Nuclear Chemistry Sub atomic particles and their properties. Huheey. N. reactions 6h in BrF3. Lee (1996). D. oxyacids of nitrogen. Mingos. 6. Butterworth Heinemann (1997). bent rules and energetics of hybridization. D. oxidation numbers. J. Gaus. MOs of diatomic molecules and walsh diagrams of BeH2 and H2O. condensed phosphates. Addison-Wesley (1993) Inorganic Chemistry. leveling effect. multicentre quadruple and Synergic. shapes of molecules. 11h C. D. 8h II. 4h SUGGESTED BOOKS 1. sulphur and halogens. structure and bonding in boranes. π and δ molecular orbital. Oxford Univ. E. Isopoly and heteropoly acids of W. Mo and V Preparation properties structure and applicatons. Electronegativity and partial ionic character. concepts of resonance and hybridization. structural models. E. polyhalides. Solvent systems. J. Earnshaw. 4. Keiter and R. Liquid drop model and Shell model of the nucleus. Silicates-classification and structures. Polymorphism of carbon. Chemistry of the Elementals. isomorphous replacement. Slaters rules. 3. E. phosphorous and sulphur. super acids. octet rule. phosphorous. 7. III. 8 . Fajans rules. pyroxenes. Cotton. Chemical Bonding A. L. Chemistry of the Main Group Elements A. sulphur. carboranes metallo carboranes. Basic Inorganic Chemistry. radius-ratio rules. layered and vitreous silicates. Keiter. Atkines and C. Cotton. Review of periodic properties of elements. Essential Trends in Inorganic Chemistry. A. Intermolecular forces. phosphazenes. structures of simple solids and Zintl isoelectric relationships in solids.nitrogen compounds. metallic bond. Shriver. H. 2.4th Edition. Born-Lande equation. Hydrogen bonds. A. John Wiley & sons (1995).FIRST SEMESTER C-101 INORGANIC CHEMISTRY – I 52 Hours I. N2O4. L. 9h B. Fourth Edition. pH and pKa. acid-base concept in non-aqueous media. NAIL Pub (1995). VSEPR model. 5th Edition.types and detection. F. 4h IV. Antiaromaticity.. Stereochemistry 10h Fischer. Tautomerism. meso-ionic compounds. Hammond postulate. Reaction Mechanisms: Structure and Reactivity 12h Generation. leaving group. cyclopentane. Effect of substrate structure. isotopic labeling. alkylidene cycloalkanes and spiranes (with a stereogenic axis).g. Alternant and nonalternant hydrocarbons.. Thermodynamic and kinetic requirements. iso-propyl. Methods of determining mechanisms: Based on the structure of products. cychexanes (monosubstituted e. Effect of structure on the strengths of acids and bases. . Ambident nucleophiles and substrates. substituent and reaction constants. Aromatic systems with electron numbers other than six (including azulene. Cram’s and Prelog’s rules. tropone. isotope effects. Nomenclature and conformations of fused rings and bridged ring systems. Acids and bases: Hard and soft acids and bases.g. Aromaticity. CIP rules. The Hammett equation and linear free energy relationship. and in allenes. groups and faces. steric effects. diols). III. attacking nucleophile. carbon free radicals. and cycloheptane. structure. dihalo. energy levels for the benzyl cation.Resonance and field effects.C-102 ORGANIC CHEMISTRY – I 52 Hours I. Effect of structure on reactivity:. resonance. SN2. determination of the presence of intermediates. Homo-aromaticity. stability and reactivity of carbocations. transition states and intermediates. R-S and M-P conventions. kinetic and thermodynamic control. methyl. Conformational analysis: Conformational analysis of cycloalkanes: cyclobutane. Newman. Taft equation. Prochirality: Enantiotopic and diastereotopic atoms. Nucleophilic substitution reaction at a saturated carbon: SN1. 11h 9 . Amino acids and Peptides Synthesis of amino acids. II. tropolone and annulenes). benzyl free-radical and benzyl carbanion. Sawhorse and flying wedge projections and their interconversions. Classification of reactions and mechanisms. and SET mechanisms. D-L conventions. cross conjugation. from stereochemical evidence. Curtin-Hammett principle. Optical isomerism: Elements of symmetry and chirality. Potential energy diagrams. Nature of Bonding in Organic Molecules 5h Delocalized chemical bonding: Conjugation. Chirality in compounds with a stereogenic centre. tert-butyl and disubstituted cyclohexanes e. carbenes and nitrenes. carbanions. IV. Aromaticity in benzenoids. dialkyl. Energy levels in odd and even-alternant hydrocarbons. Huckel’s rule of aromaticity. Hyperconjugation. 9. EEDQ. Press. pyrimidine and puine. 14. Advanced Organic Chemistry. (1999). (2000). Peptides: Chemistry and Biology. Bodansky. I R L. Structures of trehalose. SUGGESTED BOOKS 1. Blackie Academic and Professional. (1998). Cleavage of peptide bond by chemical and enzymatic methods. Solid-phase peptide synthesis: A practical approach-E. Determination of configuration of the monosaccharides. conformational analysis of monosaccharides. 10 . 11. HOBt and active esters. and chitin. (1994). flavones and isoflavones. Benjamin. gramicidin. Jakubke. 8. 5. New-Age International. N Selwad and H. Carbohydrates 7h Introduction. Stereochemistry of Organic Compounds. Jerry March. C K Ingold. synthesis and reactions of pyrazole.and Fmoc-) and carboxyl group as alkyl and aryl esters. Volumes I and II. Principles of Organic Synthesis. cellobiose. Structure elucidation of sucrose and maltose. 13. acid halides. aldaric acids and alditols. R T Morrison and R N Boyd. 3. (1999). 4. Stereochemistry. F A Carey and R J Sundberg Plenum. Solution and solid phase techniques. (1996). (1972). Wiley-VCH. 6. anhydrides in peptide bond formation reactions. V.-D. Moscow. Structure and mechanism of Organic Chemistry. Stereochemistry of Carbon Compounds. A Guide Book to Mechanism in Organic Chemistry. Synthesis of aldonic. VI. Peter Sykes. 7. Springer-Verlag NY. D Nasipuri. Deprotection and racemization in peptide synthesis. 1984. Longman. Sanger and Edman methods of sequencing. Use of DCC. Cornell University Press (1999). John Wiley. E L Eliel. isothiazole. John Wiley (2008). Advanced Organic Chemistry – Reactions. I L Finar. (1990). Preparation and reactions of coumarins. Oxford Univ. Structure. 10. H O House. meliobiose. Potapov. Z. M. Sheppard. 1988. Peptides Chemistry : A practical text book. R O C Norman and J M Coxon. lactose. Modern Organic Reactions. S H Wilen and L N Mander. 1989. Prentice-Hall. Organic Chemistry. gentiobiose. LH-RH. Mechanism and Structure. reactivity. 2. Organic Chemistry. Introduction to peptidomimetics. thiazole. chromones. Photosynthesis of carbohydrates.Classification and nomenclature of peptides. isoxazole. uronic. enkephalins. 2002. Heterocyclic compounds 7h Nomenclature of heterocyclic compounds.Protection of amino group (Boc-. Kiliani-Fischer synthesis. MIR. Synthesis of oxytocin. imidazole. Peptide synthesis. 12.C. Longman. Artherton & R. oxazole. 10h B. Postulates of quantum mechanics. Spin-orbit interaction and explanation of term multiplicities (Na-D doublet). Application to electron in a box under the influence of an electric field. Equations of wave motion: Progressive and stationary waves. Radial and angular distribution functions and their significance. Angular momentum operators and their properties. Eigen function and eigen value. Comparison of collision theory and transition state theory. HMO theory for conjugated systems. Slater type orbitals. Θ equations and statement of solution of R equation. Temperature coefficient. Schrödinger wave equation. Electron spin (Stern-Gerlach experiment). wave equation for a stationary wave (stretched string). linear and Hermitian operators. Solutions of Schrödinger equation for a free particle. Normalisation.3s. Approximate methods: Need for approximate methods. butadiene and benzene 8h II. Commutation of operators.C-103 Physical Chemistry – I 52 hours I. Quantum Mechanics A. deBroglie relation. Russell-Saunders and JJ-coupling. List of wave functions for few initial states of hydrogen-like atoms.tunneling (no derivation). orthogonality and orthonormality of wave functions. particle on a ring and particle in a threedimensional box. CHEMICAL DYNAMICS A. Factors affecting the order of reactions. Coupling of angular momenta. C and N. Macroscopic and microscopic kinetics. Diagrams of radial and angular wave functions. Application to ethylene. Ladder operator method for angular momentum. 2s. Concept of operators. Transition state theory. Physical interpretation of wave function. Laplacian. Slater determinants. Formulation of quantum mechanics: Wave particle duality of material particles. Schrödinger equation to hydrogen atom in spherical polar coordinates. Time-independent and time-dependent Schrödinger equations and the relations between their solutions. Heisenberg uncertainty principle. Application to He atom. Variation theorem-Statement and proof. Quantum numbers and their characteristics. expresiions for Slater orbitals for 1s. STOs. Thermodynamical 11 . Quantum mechanical degeneracy. Eigen functions and eigen values of angular momentum. Application of variation method to particle in a one dimensional box. 11h C. spin orbital. antisymmetry and Pauli exclusion principle. Slater’s rules for calculation of effective nuclear charge. Hamiltonian. linear oscillator and He atom. Application of Schrödinger equation to harmonic oscillator and rigid rotator. ally radical. Term symbols. Solution of Φ. Review of theories of reaction rate-Collision theory. Methods of determination of order of a reaction. Zeeman Effect. Significance of energy of activation. Total wave function of hydrogen atom. for He. Arrhenious equation. Average (Expectation) values. SCF method for many electron atoms. Rayleigh Schrödinger Perturbation theory for time-independent non-degenerate system. Perturbation method. 2p and 3d electrons (no derivation). ELBS. 5 h D.A.Pearson .K. 4.Adamson. 4h SUGGESTED BOOKS 1. (1988) Quantum Chemistry. Chemical kinetics Methods-C. (1961). (1982). 2nd edition.K. New Delhi (1995) Kinetics of Chemical Reactions-S. A. Viva. 11. Physical Chemistry. Mechanisms of thermal and photochemical reactions between hydrogen-bromine and hydrogen-chlorine. R. Ira N.formulation of reaction rates (Wyne-Jones and Eyring treatment). New Age International Publisher. 5h B. Lindemann theory and Hinshelwood theory. (1997). Tata McGraw Hill.G. Wm C Brown Publisher. Reaction between ions in solutions. R. R. 2h F. 8. Kinetics of homogeneous catalysis-Kinetics of auto catalytic reactions. ELBS. 3. Chain reactions. Prasad. Introduction to Quantum Chemistry. McGraw hill. flow method (Plug flow method and stopped flow method). Inc. P. temperature. Effect of temperature on adsorption. (1986). J. Quantum Chemistry. 13. Mechanism (lock and key theory). Comparison of enzyme catalysed and chemical catalysed reactions. New York. 12. 3h E.Mc Weeny. Significance of Michaelis-Menten constant.Jain Vishal Publications. Kinetics of enzyme catalysed reactions. Estimation of surface area using BET equation.W. Chemical Kinetics-K. New Age International (1997). 7. New Jersey. Prasad. Interscience Publisher Inc. 12 . 9.Influence of ionic strength on reaction rates (primary and secondary salt effects). Quantum Chemistrry Through Problems and Solutions. Mechanical adsorption. Surface film on liquids (electro-kinetic phenomena). 2. flash photolysis and shock tube method. Surface Chemistry: Theory and Applications. Pressure difference across curved surface (Laplace equation). Frost and R. pH.E. 5.Laidler. (2002). Kinetics of fast reactions-Study of fast reactions by relaxation method (Temperature and pressure jump). Theories of unimolecular reactions: Perrin theory.J. K. Steady state kinetics.W. Kinetics and Mechanism of Chemical Transformation-J.Levine. New York (1967).(2000). Physical Chemistry of Surfaces-A. 4h C. Principles of Chemical Kinetics-House J.Henri-MichaelisMenten mechanism.A.Bikerman. activators and inhibitors on enzyme activity.Rajaraman and J.Chandra. Decomposition of ethane. Pyrolysis of acetaldehyde. Physical Chemistry: A Molecular Approach. Academic Press. Kinetics of acidbase catalysed reactions. New York (1972). New York (1988). Surface tension and surface energy. Mc Millan. Julio de Paula. Vapour pressure of droplets (Kelvin equation). Comparison of photochemical and thermal reactions. 10. 14. K.. 7th edition. New Delhi (2001).J. Kinetics and Mechanism. Boston. 6. New Age International. Prentice Hall.Kuriakose. Comparative study of thermal and photochemical hydrogen-halogen reactions. Gibbs adsorption isotherm. (1991) Coulson’s valence. 15.Atkins. Delhi (1982). Catalytic activity of surfaces. Lineweaver-Burk plot.Chain length and chain inhibition. McQuarie and Simon. Surface chemistry-Types of adsorption isotherms. John-Wiley. Effects of concentration.Kalidas. Reversed phase liquid chromatography. Numerical problems on all these techniques IV. Turbidimetry and Nephelometry. γ-ray counter.ANALYTICAL CHEMISTRY [28 h] I. indeterminate. 1989 5. human and instrumental errors. L. Separation Techniques 9h Solvent Extraction-Types-batch. Ed.mean. Principle. absolute error. Beer-Lambert’s law. Analytical Chemistry. Ewing. methodic. West. F test. Thomson Asia Pvt. relative error. SUGGESTED BOOKS 1. range average deviation. Terminology. relative average deviation. G. Ionisation. Instrumental methods of Chemical Analysis. applications and numerical problems. Q test. Skoog. 1988. 3. McGraw-Hill. Radiotracer technique.Types. W. derivation. 5th Edition. New York. Willard. Holler and Crouch. 4. John – Wiley and Sons Inc. derivation. verification. al ELBS/Longman. Column. Set. Nernst distribution law. Measure of central tendency-. Thomson Asia Pvt. Chromatography. Ltd(2004) 6. Dean and F. neutron activation analysis. Determinate. Gary D Christian. J. West. 2D-thinlayer chromatography. selectivity. III. (1994) 2. CBS Publishers (1996). Working principles of GM counter. Single beam & double beam UV-VIS spectrophotometer. II. continous. Fundamentals of Analytical Chemistry. Instrumental Methods of Analysis. median. Sandell sensitivity. Jeffery et. standard deviation and variance. Use of radioactive isotopes in solving analytical and Physico chemical problems. Instrumentation and applications of Fluorimetry.High performance liquid chromatography. Application of quantitative and qualitative analysis. photometric titrations. Gas chromatography. Medium Performance liquid Chromatography. Fundamentals of Instrumental Analysis. 5th edition. Distribution coefficient. Optical Methods of Chemical Analysis 9h Interaction of electromagnetic radiation with matter. Super critical liquid chromatography.. Criteria for rejection of observation. A. A. 13 . Vogel’s text book of Quantitative Chemical analysis 5th edition. efficiency. 52 hours Part A . Thinlayer. 8th Edition. Applications of all these techniques. Skoog. Ltd (2004). H. L.C-104 ANALYTICAL CHEMISTRY AND MATHEMATICS FOR CHEMISTS. Merritt . Principles of paper. Errors in Chemical Analysis 5h Classification of errors. choice of solvent. Distribution of random errors – frequency distribution. molar extinction coefficient. deviations. Isotopic dilution analysis. Ringboms’ plot. confidence limits.H. confidence intervals. Holler and Crouch. Accuracy and precision.. Radioanalytical Methods 5h Radioactivity. Electrophoresis. the normal error curve. Method of partial fractions. 2h Probability: Review of permutations and combinations. (for explicit functions only). 2h Fourier series: Simple problems. adjoint and inversre of a square matrix. eigen values and eigen vectors. derivative as a rate measure – velocity and acceleration. log u etc. 2h 14 . Solution of differential equations by power series method. partial derivatives. linear and homogeneous equation.Part B . f(D)y=0.derivative as a slope of the tangent. scalar and vector triple products and their applications. 4h n Calculus: Rule for differentiation.simple substitution.Integration by parts.problems restricted to polynomials 2h Integration : Basic rules. Definite integral and application to areas of plane curves. exact first order equations. sin u. Tensors and their applications. 3h Elementary Differential Equation: Variable seperable.second derivative test. determinant of a square matrix. 2h Second order homogeneous differential equation with constant coeffecients.method of least squares.maxima and minima. increasing and decreasing functions. transpose. dot and cross products. Probability and addition theorem for mutually exclusive events and multiplication theorem for independent events. Solution to system of linear equations (a) by matrix method & (b) by Cramer’s Rule.) implicit differentiation and parametric differentiation and successive differentiation of order 2. Curve Fitting. 2h Applications of differentiation. Characteristic equation of a square matrix.point of inflections. 3h Matrix Algebra: Review of different types of matrices (including Hermitian and skewHermetian).versa. Chain Rule (for f(x)= U . matrix addition and multiplication. co-ordinate transformation from cartesian co-ordinates to spherical and cylindrical co-ordinates and vice. 2h Functions of several variables.MATHEMATICS FOR CHEMISTS [24 h] Vectors: vectors. 3.W. Preparation and quantitative analysis of inorganic complexes: 1. The National Pub. Inorganic Semimicro Qualitativwe Analysis. 3.Mendham. 8. B. C105 AND C106: PRACTICALS (4 days a week 4 ½ hours a day) C105 Inorganic chemistry practical –I A.S. Potassium trioxalatofetrrate (III) trihydrate. Inorganic Chemistry Practical-II 1. Hexammine cobalt (III) chloride. ELBS (1986). McGraw Hill. 15 . Ramanujam. 3. Vol II. 4. D.Co. Semi-micro qualitative analysis of mixtures containing two each of common cations and anions and one of the following less familiar elements: W. Se. Bosco. Narosa Publishing House. 3. Hirst. 2. 7. Thomas. Vogel’s Text book of Quantitative Chemical Analysis. U and Li. Mo. 6. V.and R. Jeffery and J.(1974).V. G.H. Longman publishers. Chemical mathematics.Marr and B.Bassett.H. Longman Scientific and Technical (1999). Analysis of alloys: (a) German silver (b) Steel (c) Solder. mathematical preparation for Physical Chemistry.J. V. Theory and Problems in Mathematics. 2. Practical Inorganic Chemistry. Th. Cis and trans-potassium dioxalatodiaquochromium(III) C106.Mendham. Colorimetric determination of nickel SUGGESTED BOOKS 1. 4.C. Tebbutt. Short Course in differential equations. Wiley publishers. Basic mathematics for Chemists. J. 5. Calculus and analytical Geometry. 2. Vogel’s Text book of Qualitative Chemical Analysis. Ce. Ferrous oxalate. Finney.SUGGESTED BOOKS 1. Rockett.Denny.M. S. Mathenmatics for Chemistry. G.Bassett. F. IBH Publishers. Doggett and Sucliffe. Longmann Publishers. Volumetric/redox and gravimetric determination of the following mixtures:(a)Copper and nickel (b) Copper and iron (c) Copper and zinc(d)Nickel and zinc 2. Daniels. 4. 5th Edition. Jeffery and J. Rainville and Bedient. G. Von Nostrand Reinhold (1972). Gravimetric determination of Fe in an iron ore as Fe2O3 1. Algebra. Zr.hall and Knight. Benzanilide from benzophenone. SUGGESTED BOOKS 1. Saponification value of oil. 3. B. (1996). Allied Publishers. 2. II Quantitative analysis 1. 6. Practical Organic Chemistry – Mann and Saunders. Cannizarro reaction: Benzaldehyde. 5. 2. 7.4-dinitroaniline 11. Benzilic acid from benzoin.105 Organic Chemistry Practical-I (4 days a week. 7. 5. 2. 4½ hours a day) Preparation (one stage) 1. Friedel-Crafts reaction: Benzene and Acetyl chloride. Sandmeyer reaction: 4-Chlorotoluene from 4-toluidine.C. 4-Nitroaniline from aniline. 2. 6.B. Estimation of keto group. Laboratory manual of Organic Chemistry. 4. 3. Synthesis of Hydantoin. 6. Determination of equivalent weight of carboxylic acids.6-tribromoaniline 12. Synthesis of 2. 5.4-dichlorophenoxyacetic acid II Qualitative analysis Systematic analysis and identification of organic compounds. M V Sitaraman and T R Govindachari. 16 . 4. Estimation of amines/phenols. Dey. Iodine value of oil (chloramine-T method). (1980). New Delhi. 3. Preparation of S. 4. Claisen-Schmidt reaction: Acetophenone and Benzaldehyde / benzaldehyde. Fries rearrangement: Phenyl acetate. 8. 9. Synthesis of Acridone. Synthesis of p-iodonitrobenzene 10.4. Estimation of glucose. Synthesis of N-Phenyl-2. Pechmann reaction: Resorcinol and ethylacetoacetate. Anthranilic acid from phthalic acid. Synthesis of 2. 8. 2. Oxidation of Cyclohexanol. 3-Nitrobenzoic acid from methyl benzoate. 4½ hours a day) Preparation (Two and three stages) Preparation of the following compounds: 1.4-Dinitrophenylhydrazine from chloronitrobenzene.Benzylisothiuronium chloride. I acetone and C-106 Organic Chemistry Practical – II I (4 days a week. 9. Construction of Phase diagram of a two-component system and determination of eutectic temperature and eutectic composition. Ahluwalia. 4½ hours a day) Chemical Kinetics 1. Simultaneous estimation of Mn and Cr in a solution of KMnO4 and K2Cr2O7 colorimetrically. B.Text Book of Practical Organic Chemistry. Adsorption of oxalic acid on charcoal. 12. Mohan. Determination of the velocity constant. Verification of Langmuir adsorption isotherm. Advanced practical organic chemistry. 2000. Determination of partial molal volume of NaCl-H2O system by apparent molar volume method. Adsorption 14. Vogel. 4. temperature coefficient. I and II. 6. K. Allied Publishers. Mahapatra and A. Partial Molal Volume 11. 17 . catalytic coefficient. (1964). Practical organic chemistry (Quantitative analysis). 10. Determination of molecular weight of a solute by cryoscopic method. Calcutta. Test Book of Quantitative Organic Analysis. Velocity constant for the saponification of ethyl acetate. B. A Handbook of Organic Analysis – Clarke and Hayes. K. 7. B.A. M. I. 8. Vogel. Cryoscopy 10. 9. (1996). 1992. 4. t½ and energy of activation for the acid hydrolysis of methyl acetate. Ghoshal. C 105 Physical Chemistry Practical – I (4 days a week. V. 6. Vol. Evaluation of Arrhenius parameter for the reaction between potassium persulphate and potassium iodide (Ist order). R. Test for the validity of Fe and Cu ions by Beer – Lambert Law and estimation of unknown concentrations in solutions. 3. Dhingra. Dey. 2. Phase diagram 13. New Delhi. Kinetics of reaction between K2S2O8 – KI colorimetrically. S. 8. 1992. Aggarwal. Calculation of molar extinction coefficient. 7. I. A. An advanced course in practical chemistry. Ahluwalia. 5. 3. Colorimetry 5. Govindachari. Determination of the order of reaction between hydrogen peroxide and potassium iodide (clock reaction). Determination of concentration of Fe using EDTA by spectrophotometric titration. Universities Press (India). 2000. Himalaya Publishing House. V. (1996). Comprehensive practical organic chemistry : Preparation and quantitative Analysis. New central book agency. 2000. Titration of ferrous ammonium sulfate with potassium permanganate colorimetrically. Comprehensive practical organic chemistry: Qualitative analysis. Determination of partial molal volume of ethanol by reciprocal density method/ intercept method. R.A. Universities Press (India). Nad. Sitaraman and T. V. Kr. J. (1968). Experimental Physical Chemistry by Daniel etal. Determination of pH of buffers by using quinhydrone electrode and comparison of the pH values obtained with glass electrode. New Age International. Pergamon Press. Delhi. Verification of Onsager’s equation .M. Findlay’s Practical Physical Chemistry revised by Levitt. Newcombe and others. 4. Dissociation constant of weak electrolyte (weak base – NH4OH. weak acid and salt (copper sulfate) against strong base. 5. Practical Physical Chemistry by A. weak acid – CH3COOH). (2006). G. 14. SUGGESTED BOOKS 1. Ghosh . Athawale and Parul mathur. 11.C 106 Physical Chemistry Practical – II (4 days a week. Titration of silver nitrate against potassium chloride. Experimental Physical Chemistry by V. 4. Practicals in Physical Chemistry. Precipitation titration: lithium sulfate against barium chloride. 13. James and D. Experimental Physical Chemistry by Wilson. Experiments in Physical Chemistry by Shoemaker and Garland. Longman’s London (1966). Longman Group Ltd. 12. 2. Potentiometric titration of ferrous ammonium sulfate against potassium dichromateCalculation of formal redox potential of Fe3+ / Fe2+.(1996). Goel Publication house. Experiments in Physical Chemistry by J. McGraw Hill International edn. 7. 4½ hours a day) Conductometry 1. Sindhu. Advanced Practical Chemistry by J. Meerut(1989). 3.determination of λ0 of an electrolyte. Titration of mixture of strong and weak acids against strong base. Titration of weak acid against a strong base using quinhydrone electrode and calculation of pKa value of the weak acid. Titration of mixture of strong acid.E. Determination of EMF of a concentration cell and calculation of solubility product of AgCl. Mac-millan 9. 10. 6. A Mordren Approach by P. Bharathi Bhavan. 2. Titration of weak acid against weak base. Publishers. Pritchard. Potentiometric titration of potassium iodide against potassium permanganate. 15. (1974).. Determination of single electrode potential of Cu2+ / Cu and Zn2+ / Zn and testing the validity of Nernst equation. McGraw Hill (1962). Yadav. 6.B. 3. New York (1962). Determination of the solubility of sparingly soluble salt. 18 . Titration of a mixture of HCl and CH3COOH potentiometrically and determination of the composition of the mixture.S. New Delhi (2001). D. Potentiometry 8. 8. 9. 5. 7. Cr divalent Mn.H. isocyanide. dihydrogen. selection rules. stereochemistry. Electronic Spectra of transition Metal Complexes. 5. dinitrogen and tertiary phosphine complexes. R. G. 7. Cotton effect and magnetic circular dichroism. Metal-Ligand Equilibria in solution Step-wise and overall formation constant and their relationship. Inc. polarography and by ion exchange methods. Spectrochemical series.Langford.B. D.Earnshaw. spin crossover. Carlin.Cotton . E. N. 3. 19 . Magnetic properties of lanthanides and Actinides. Atkins and C.W.E. Spectroscopic ground states. John Wiley & sons.A. Magnetic Properties of Metal Complexes Magnetic susceptibility.Wilkinson and P. Orgel correlation and Tanabe-Sugano diagrams. Racah parameters. term symbols for dn ions. kinetic and thermodynamic stability of metal complexes. charge transfer spectra. spin-orbit coupling.P. Metal-Ligand bonding Crystal field theory –limitation.Lever.A. Spectral properties of Lanthanides and actinides. Basic Inorganic Chemistry. spectrophotometry. Evidences for metal-ligand orbital overlap. carbonyl. factors affecting the stability of metal complexes with reference to the nature of the metal ion and ligand. Butterworth Heinemann (1997). 2. 8. dioxygen.N. trends in step-wise constant.II SEMESTER C-201 INORGANIC CHEMISTRY –II 52 hours I.L. A.Sathyanarayana.Gaus.L. Magnetochemistry. J. 9h III. Universities Press (2001). [CoCl4]2-. P.Keiter.Keiter and R. Addition-Wesley (1993). 14h IV. CD. Press (1998).M. D. 7h SUGGESTED BOOKS 1. 6. Co and Ni.Shriver. Inorganic Chemistry. determination of binary formation constant by pH-metry. Stereoisomerism-chirality. 12h V. optical activity. Electronic Absorption Spectroscopy and Related Techniques.F. F. Oxford Univ. Inorganic Electronic spectroscopy.P. Nephelauxetic series. types of magnetic behavior.N. coordination Nos. chelate and macrocyclic effect and their thermodynamic origin. Springer Verlag. stereochemical non-rigidity. (1968) Essential Trends in Inorganic Chemistry. 4th Edition. calculation of Dq. Press) (1994). 2nd Edition. ELBS (Oxford Uni. nitrosyl. D. absolute configurations. diamagnetic correction. Ferro and antiferromagnetic coupling. Inorganic Chemsitry. self-assembly in supramolecular chemistry. 4. B and β parameters.Greenwood and A.E.L.Mingos. Jahn-Teller distortion in metal complexes and metal chelates. orbital contribution.bonding). Structure and bonding Hydride. Chemistry of Elements. Huheey. 10h II. Spectra of 3d metal aqua complexes of trivalent V. 6th Edition (1999). Elsevier.3 to 8.ORD. MO theory (including π. angular overlap model. Reactivity-effects of substrate structure. Tiffeneau-Demjanov reaction. Stevens.C-202 ORGANIC CHEMISTRY-II 52 Hours I. Vilsmeier-Haack reaction. Lossen and Schmidt rearrangements. LiAlH4. acids. The ortho/para ratio. Orientation of the double bond. sulfonylation reactions. Pinacol-Pinacolone. Addition of alkenes and/or alkynes to alkenes and/or alkynes. Wittig and Favorskii rearrangements. Orientation and reactivity. Addition to carbon-heteroatom multiple bonds: Mechanism of metal hydride reduction (NaH. von Richter. attacking base. Rearrangements 12h Wagner-Meerwein. Hofmann. Arndt-Eistert reaction. NaBH4) of saturated and unsaturated carbonyl compounds. esters and nitriles. Gatterman reaction. Fries. Gatterman-Koch reaction and Hoesch reaction. Firtsch-Buttenberg-Wiechell rearrangement. Wittig. benzyne and SRN1 mechanisms. IV. Effect of leaving group. Nucleophilic substitution reactions: The SNAr. Hydrolysis of nitriles and addition of amines to isocyanates. Neber rearrangement. Hydrogenation of double and triple bonds. II. stereo. E2C and E2H mechanisms. E1 and E1cB mechanisms and their spectrum. LiH. Addition Reactions 12h Addition to carbon-carbon multiple bonds: mechanistic and stereochemical aspects of addition reactions involving electrophiles. the leaving group and the medium. Michael reaction. Vitamin B6 7h 20 . Amination. Aromatic Substitution Reactions 12h Electrophilic Substitution Reactions: The arenium ion mechanism. Formation of xanthates. Elimination Reactions 4h The E2. nucleophiles and free radicals. Orientation and reactivity. Beckmann. Goldberg reaction. Curtius. leaving group and attacking nucleophile. hydrogenation of aromatic rings. SN1. Benzil-benzilic acid rearrangement. Sommelet-Hauser and Smiles rearrangements. Bucherer reaction and Schiemann reaction. Addition to cyclopropane ring. Benzidine rearrangement. Mannich and Stobbe reactions. orientation in other ring systems. Ene synthesis. Diazonium coupling. Addition of Grignard reagents and organolithium reagents to carbonyl compounds and unsaturated carbonyl compounds. Mechanism and orientation in pyrolytic elimination reactions (including Chugaev reaction). III. V Vitamins Biological importance and synthesis of Vitamins A. Wolff.and chemoselectivities. Dienone-phenol rearrangement. Regio. Conversion of aldehydes to nitriles. Energy profile diagrams. ipso attack. Baeyer-Villiger oxidation. Vitamin B1 (thiamine). Quantitative treatment of reactivity in substrates and electrophiles. Reactivity: effect of substrate structure. Wiley (2000).(pyridoxine). F. Vitamins K1 and K2. 10. Prentice-Hall (1998). C. molecular tweezers. Vitamin C. T. Volumes I and II.partial molar free energy. Wilen and L. 2. 8. Stereochemistry of Organic Compounds. 6. Determination of these quantities. Structure and function of receptors with molecular clefts. Fermi-Dirac statistics . Canonical. L. grand canonical and micro canonical ensembles with corresponding distribution laws (using Lagranges method of undetermined multipliers). Activity and activity coefficient. calixarenes and cyclodextrins. Ingold. Heat capacity behaviour of solids. Blackie Academic and Professional (1996). Carey and R. Nasipuri. pantothenic acid. 4. Cyclophanes. R. H. I L Finar. 5. A Kar.postulates of ensemble averaging. A. Principles of Organic Synthesis. Phase rule . Stereochemistry of Carbon Compounds. folic acid. Peter Sykes. Structure and Mechanism of Organic Chemistry. O. N. 9. Longman. John Wiley (1994). Applications of partition functions. Eliel. Morrison and R. Relationship between mole fraction. partial molar heat content and their significance. riboflavin. Synthetic Molecular receptors 5h Definition and significance. molality and molarity activity coefficients. A Guide Book to Mechanism of Organic Chemistry. New-Age International (1999).free energy. Thermodynamics . C-203 PHYSICAL CHEMISTRY-II 52 hours 26h Classical Thermodynamics : Brief resume of concepts of laws of thermodynamics. J. VI. House. Plenum (1990). Determination of activity coefficient by EMF and solubility methods. Vitamin H (biotin). partial molar volume. H. Coxon. 3. Mechanism and Structure. application of phase rule to three component systems 9h Statistical Thermodynamics: Concepts of distribution. K. Partition functions . SUGGESTED BOOKS 1. S. Sundberg. rotational.distribution law and applications to metal. Advanced Organic Chemistry. Organic Chemistry. Calculation of thermodynamic properties in terms of partition functions. vibrational and electronic partition functions. 10h 21 I. M.Derivation of phase rule from the concept of chemical potential. D. Jerry March. ROC Norman and J. Boyd. Partial molar properties. John Wiley (2008). 7. Receptors with multiple hydrogen bonding sites. Benjamin (1972). Mander. N. Ensemble averaging. Organic Chemistry. Longman (2000). chemical potential and entropies. 11.translational. Medicinal Chemistry. Advanced Organic Chemistry – Reactions.Excess functions for non-ideal solutions. Cornell University Press. Concept of fugacity and its determination by graphical method and compressibility factor method. thermodynamic probability and most probable distribution. (1999). Chemical equilibrium and equilibrium constant in terms of partition functions. Vitamin E (α-tocopherol). E. Non ideal systems . Modern Organic Reactions. Bose-Einstein statistics-distribution law and application to helium. Gupta (Wiley eastern Ltd. M. N. Mac Millan India Ltd. 3h II. Nash. Smith. New Delhi (1942). Modern Electrochemistry. AddisonWiley (1970). 3rd ed. Cleaver – Hume Press. J. (1991).Samuel Glastone. (1960). chemical reaction etc. methods of determination. corrosion monitoring and prevention methods. heat flow. East-West edition. Kuriacose. 12.N.Bockris and A.D. Potter. exchange current density. phenomenological equations. Structure of electrified interfaces.Samuel Glastone. 3. . C. Electrochemistry. New Delhi. 7. 2. Determination of heat capacity at low temperature. Glasstone. Helmholtz. Elementary Statistical Thermodynamics . Stern and Devanathan models.K.Raddy. quantization of charge transfer. Rajaraman and Kuriacose.Y. An Introduction to Electrochemistry.) . N.ELECTROCHEMISTRY 26h Electrochemistry of solutions: Debye-Huckel-Onsager treatment and its extension ion solvent interactions.Mc Quarrrie. Thermodynamics. Thermodynamics of electrified interface equations. Electrocatalysis – influence of various parameters.R. Characteristic temperature. Quantum aspects of charge transfer at electrodes-solution interfaces. London) 1988. forms of corrosion. Entropy balance equation for different irreversible processes (e. derivation of Butler-Volmer equation. 5. entropy production and entropy flow.M. L. I and II. structure of double layer interfaces. microscopic reversibility and Onsager’s reciprocity relations. Edmund.O.) 1993.Heat Capacity of Solids Theories of heat capacity of Solids-Einstein’s and Debye’s equation. Mc Millan. 1986. Lippmann equations (surface excess). J. Guoy-Chapman. Text Book of Physical Chemistry. Polarography theory.. Principles and Applications of Electrochemistry . Tafel plot. Donald A. Elements of Classical and Statistical Thermodynamics. Rajaraman and J. (1999). 2nd edition. Principles and Applications. 1. Molecular thermodynamics. 6. Hydrogen electrode. Over potentials: Concentration and activation over potential.Simon University Science Books.D. Debye-Huckel-BJerum mode. Ilkovic equations. 4h Non Equilibrium Thermodynamics: Thermodynamic criteria for non-equilibrium states.g. Derivation of electro-capillarity. California. (Chapmanhall. tunneling. non equilibrium stationary states. half wave potential and its significance. 4.Vol.Crow. (1986) 2. Semiconductor interfaces – theory of double layer at semiconductor. 22 1. East West. Introduction to corrosion. New York (1978).Transformations of the generalized fluxes and forces. K. Effect of light at semiconductor-solution interfaces. homogeneous theory.. SUGGESTED BOOKS Kinetics and mechanism of chemical transformation. Plenum. Statistical Thermodynamics. C. Affiliated East-West Press. (1982). John D. Thermodynamics for Chemists by S. electrolyte solution interfaces. 3. London (1961) 13. Plenum Press. Symmetry elements and symmetry operations. character tables and their uses (representations for the Cn. characters of representations. Born-Oppenheimer approximation.time-dependent perturbation theory. selection rules. Q and R branches. harmonic and anharmonic oscillators. centrifugal distortion and the spectrum of a non-rigid rotor. simple theorems in group theory. computation of intensities. subgroups. vibrational wave functions and their symmetry. Symmetry and Group Theory in Chemistry 12h Definition of groups. classes. fundamentals. Great Orthogonality Theorem (without proof) and its applications. conjugate relationships. expression for the energies of spectral lines. computation of intensities. Unifying principles 3h Interaction of electromagnetic radiation with matter. Cnv.identifying non-zero matrix elements. Cnh.linear. Schöenflies notations. Infrared Spectroscopy 12h Vibrations of molecules. effect of isotopic substitution Diatomic vibrating rotor. rotational wave functions and their symmetry. selection rules. translations.rotational energy expression. vibrations and rotations. cyclic groups. Dnh etc groups to be worked out explicitly) Mulliken symbols for irreducible representations Direct products. overtones and combinations Vibration-rotation spectra of polyatomic molecules. effect of isotopic substitution. reducible and irreducible representations. vibrational-rotational spectra of diatomic molecules. breakdown of the Born-Oppenheimer approximation Vibrations of polyatomic molecules: Normal coordinates. selection rules. expression for the energies of spectral lines. FTIR 23 . transition moment integral.C-204 SPECTROSCOPY-I 52 hours I. Microwave Spectroscopy 6h Rotations of molecules. point groups.parallel and perpendicular vibrations of linear and symmetric top molecules Techniques and instrumentation.symmetry and spin forbidden transitions III. Applications of group theory to quantum mechanics. energy level diagram. vibrational energy levels and wave functions. representations of groups by matrices. derivation of the orthonormalization conditions II. symmetric top and asymmetric top molecules Stark effect.vibrational energy expression. energy level diagram. Rotational spectra of polyatomic molecules. rigid diatomic molecule. P. techniques and instrumentation IV. hot bands. 4 days per week) Inorganic Chemistry practicals – I & II Organic Chemistry Practicals – I & II Physical Chemistry Practicals . 4. Spectroscopy. predissociation Electronic structure of diatomic molecules. quantum theory of the Raman effect. C. Introduction to Molecular Spectroscopy.radiative (fluorescence and phosphorescence) and non-radiative decay. F. G. 2. polarizability as a tensor. spectrum of singlet and triplet molecular hydrogen Electronic spectra of polyatomic molecules. Vols. Electronic Spectroscopy 12h Born-Oppenheimer approximation.5 hrs per day. Straughan and W. classification of states by electronic angular momentum-σ. Wiley Eastern (1976). Students Edition) (1988). Introduction to Molecular Spectroscopy. rotational fine structure. 3. Polarization of Raman scattered photons Structure determination from Raman and IR spectroscopy-AB2 and AB3 molecules Techniques and instrumentation VI. McGraw Hill (Int. Fortrat diagram. Pure rotational Raman spectra of linear and aymmetric top molecules. 1-3.basic results of MO theory. Van Nostrand (1965). spectrum of HCHO. Chemical Applications of Group Theory. 5. J. rotational fine structure. Dissociation energy. McGraw Hill (Int. Molecular Symmetry. Walker. S. N. Chapman Hall (1976). M. internal conversion SUGGESTED BOOKS 1. Banwell.localized MOs. TMH Edition (1994). 6. intensities by FranckCondon principle. Graybeal. Schonland. Hollas. vibrational Raman spectra. Raman Spectroscopy 7h Classical theory of the Raman effect. P. rule of mutual exclusion. selection rules. Raman activity of vibrations. Every student will carry out experiments in each of the three branches of chemistry on a rotation basis from 1st to 3rd Semester 24 . Modern Spectroscopy. D. C 205 and 206 Practicals (4. and φ molecular orbitals.π. Cotton.V. A. Barrow.I & II Experiments are as in first semester. polarizability ellipsoids.O and S branches. Students Edition) (1990). M.δ. vibrational coarse structure. B. J. John Wiley. change of shape on excitation Decay of excited states. Molecular Spectroscopy. D. criteria for the selection of indicators. Precipitation titrations: 5h Solubility product. acidic and basic titrants. VII. determination of water in samples. Applications: Oxidants such as Permanganate. end point signals. Applications: Estimation of F-. conditional stability constants. end point signals. applications of non-aqueous titrations. Iodates. pH calculations. homogeneous precipitation. effect of pH and second complexing agent on the conditional stability constant and titration curve. Volhard and adsorption indicators.THIRD SEMESTER ANALYTICAL CHEMSITRY SPECIALISATION C . acetylenes and mixture of halides IV. co-precipitation. K+. C2O42-. Mohr. carboxylic acids. dichromate. acid anhydrides and carbonyl compounds. Indicators. Non-Aqueous titrations: 5h Acid –base titrations in non-aqueous solvents. Acid – Base Titrations: 5h Basic principles. methods of titration. Titrations in glacial acetic acid and ethylene diamine. theory of indicators. Ce (IV). II. application to quantitative analysis of some organic compounds. important precipitating agents and their significance in inorganic analysis. Titration curves for polyfunctional acids [H3PO4]. suitability of polydentate ligands as titrants. interference and their elimination. leveling and differentiating solvents. polyamines and amino acid systems. Redox Titrations: 6h Nernst equation. types of EDTA titrations. CO32-.alcohols. Karl-Fischer titrations: 5h Stoichiometry of the reaction. Titration curves for mono functional acids and bases. Selectivity by pH control. derivation of titration curve. Gravimetric analysis: 5h Formation and treatment of precipitates. III. expressions for the different forms of EDTA in solution as a function of pH. Standard & formal potentials.classification of solvents. Feasibility of redox titration. masking and demasking. bromate. fractions of phosphoric acid species as a function of pH. titrations involving monodentate V. Titration of multicomponent system. Complexometric titrations: 6h Complexometric titrations with particular reference to EDTA titrations.301 AC PRINCIPLES OF CHEMICAL ANALYSIS 52 hours I. Adjustment of analyte’s oxidation state. VI. 25 . metal ion indicators. standardization of the reagent using water-in-methanol. preparation of the reagent. titration method. Titration curves. Theoretical principles: Titration curves. VIII. Kinetic methods of analysis: 5h Rate laws, psuedo first order kinetics, types of kinetic methods, fixed time methods. Applications of catalytic and non-catalytic kinetic methods. IX.Electroanalytical techniques 10h Membrane indicator electrodes- Classification of membranes, properties of ion-selective membranes, the glass electrode for PH measurements, glass electrodes for other cations, crystalline membrane electrodes,liquid membrane electrodes. Ion-selective field-defect transistors (ISFETs): Mechanisam of ISFET ion-selective behavior, application of ISFETs. Molecular selective electrode systems: Gas-sensing probes, biocatalytic membrane electrodes, disposable multiplayer p-ion systems. SUGGESTED BOOKS 1. 2. 3. 4. 5. 6. 7. 8. Fundamentals Of Analytical Chemistry-Skoog, West And Holler 7th Edition Saunders College Publishing Int.Ltd. (1996) Modern methods of Chemical analysis-Pecsok, Shields, Cairns and McWilliams (2nd edition), John Wiley and Sons (1976). Vogel’s Textbook of Quantitative Inorganic Analysis, Bassett, Denney, Jeffery and Mendham, (4th edition) ELBS (1989). Analytical Chemistry-G.D.Christian (5th edition) John Wiley & sons (19946). Treatise on analytical Chemistry-Kolthoff, Elving and Krivan (2nd edition) John Wiley & Sons (1986). Commercial methods of analysis-Snell and Biffen, McGraw Hill, (1944) Hand Book Of Instrumental Techniques For Analytical Chemistry, Frank Settle, Prentice Hall PTR (1997) Fundamentals of Analytical Chemistry, Eigth Edition, Skooj, West,Holler and Crouch; Thomson Asia Pvt. Ltd(2004). C-302 AC REACTION MECHANISM, CATALYSIS AND ORGANOMETALLIC CHEMISTRY 52 hours A. Kinetics and mechanism Labile, inert, stable and unstable complexes; Classification of mechanisms-energy profile of reactions having different mechanisms. 3h Substitution in square planar complexes: Trans effect, trans influence, theories of trans effect, application of trans effect in the synthesis of new complexes. 3h Mechanism of ligand substitution in octahedral complexes-kinetics, leaving groups, chelate and metal effects, Acid and Base catalysis: acid catalyzed equation and anation reactions, base hydrolysis, conjugate base hydrolysis, Stereochemistry of octahedral substitution, Application of ligand substitution reactions for the synthesis of new octahedral complexes. 6h Electron transfer reactions: complementary and non-complementary, outer-sphere electron transfer, Marcus equation. Inner-sphere electron transfer-one and two electron transfer. Use of electron transfer reactions for the synthesis of new complexes. 5h Oxidative addition , reductive elimination, Isomerisation, migratory insertion reactions. 3h 26 B Catalysis 16h Introduction basic principles, industrial requirements, thermodynamic and kinetic aspects, classification of catalytic systems. Catalysis involving metal complexes and organometallics: hydrogenation, asymmetric hydrogenation, hydroformylation (oxo process), Wacker processacetaldehyde from ethylene; Reppe Monsanto process-acetic acid from methanol, Reppe carbonylation-acrylic ester from acetylene; ethylene glycol from synthesis gas, water gas shift(WGS)reaction, Ziegler-Natta catalysis, Fischer Tropsch process C Organometallic chemistry 16h Organometallic complexes, stability and decomposition pathways, classification of ligands, Nomenclature of organometallic complexes, 16- and 18-electron rules, Electron counting covalent and ionic models. Synthesis, structure , bonding and decomplexation reactions of organotransition metal complexes having σ- and π -M-C bonds σ-Bonded systems involving carbonyls, carbenes and carbynes π-bonded systems involving dihapto to octohapto ligands like acetylene, olefins, allyl moieties, butadiene, cyclobutadiene, cyclopentadiene, arenes, cyclohexa and cycloheptadienyl moieties, cyclohepta and cyclooctatrienes, cyclooctatetraene moities, Fluxional behaviour in organometallic compounds, Isoelectronic and isolobal concepts SUGGESTED BOOKS 1.Inorganic and Organometallic reaction mechanisms, J.D.Atwood, Brooks/cole publishing co. (1985). 2.Reaction mechanisms of Inorganic and Organometallic systems, J.B. Jordon, Oxford University press, 2nd edition (1998). 3. Inorganic Chemistry, G.L Miessler and D.A. Tarr, 4. Organometallic Chemistry, R.C. Mehrotra and A. Singh, Wiley Eastern (1991). 5. Principles and applications of Organo-transition metal chemistry, J.P. Colman and L.S. Hegedus, University Science Book (1980). 6. The Organometallic Chemistry of the transition elements, R.H. Crabtree, John Wiley & Sons. (1998). 7. Catalytic Chemistry, B.C. Gates , John Wiley & Sons (1992). 8. Homogeneous catalysis by metal complexes, M.M. Taqui Khan and E.A. Martell, Academic Press (1974). 9. Principles and application of the organotrnsition metal chemistry, J. P. Collman, L. S. Hegedus, University Science books, 1980. 10. Organometallics, Vol. 1 & 2, M. Bochmann, Oxford Chemistry primers, Oxford University Press, 1994 11. Organotransition metal chemistry, S. G. Davies, Pergamon Press, Oxford, 1982. 12. Applied organometallic chemistry and catalysis R. Whyman oxford University press,2001 27 C - 303 ADVANCED ANALYTICAL TECHNIQUES (Common to Inorganic and Analytical Chemistry) 52 hours 1 Optical spectroscopy methods 15h Atomic spectroscopy, absorption, emission, fluorscence techniques, principles and differences, Flame AAS, Instrumentation, different types of nebulizers, Nonflame techniques, GAAS, electrothermal vapourisers, cold vapour AAS, radiation sources, HCL, EDL, TGL etc. detectors, photoemmissive cells, PMT, photodiodes, Interferences, spectral, chemical, matrix, background absorption, correction methods, deuterium arc, zeeman effect, SmithHieftje methos, single beam and double beam instruments, evaluation procedures, applications of AAS, AES and AFS. Inductively coupled plasma optical emission spectrometry, theory, ICP characteristics, sample introduction methods, tourch configuration and view modes, analytical performance. Microwave induced plasma systems in atomic spectrometry, principal processes, mass spectrometry in the analysis of inorganic compounds 8h II Electroanalytical techniques 12h Electrode Potentials, Currents in Electrochemical cells, Potentiometric titrations. Electrogravimetry, Coulometry, and Coulometric titrations. Voltammetry, HydrodynamicVoltammetry, Cyclic voltammetry, Anodic stripping voltammetry, Polarography, Pulse polarography and Amperometry. III Thermal methods of analysis Principle, methodology and applications: thermogravimetric and differential thermal analysis, differential scanning calorimetry; Thermo-mechanical and dynamic mechanical analysis ; thermometric titrations. IV Analysis of Biomolecules 9h Introduction, single biomolecule detection and characterization, Fluorescence based biosensors, mass spectrometry in structural biology, NMR of biomolecules, Raman spectroscopy in analysis of biomolecules, Voltammetry in Vivo for chemical analysis of nervous system SUGGESTED BOOKS 1. Analytical Chemistry. Gary D Christian, 5th Edition, John – Wiley and Sons Inc., (1994) 2. Fundamentals of Analytical Chemistry.D. A. Skoog, D. M. West and F. J. Holler, 7th Edition, Saunders College Publishing (1996). 3. Instrumental methods of Analysis.H. H. Willard, L. L. Merrit , J. A. Dean and F. A. Set, CBS Publishers (1996). 4. Instrumental methods of Chemical Analysis, G. W. Ewing, 5th edition, McGraw-Hill, New York, 1988. 5. Electrochemical methods: A.J. Bard & l. R. Faulkner, 2nd edition, Wiley, New York, 2000. 6. Vogel’s text book of Quantitative Chemical analysis 5th edition, Ed., Jeffery et. al ELBS/Longman, 1989 7. Encyclopedia of Analytical Chemistry: Ed. By R.A. Meyers Vol. 1 – 15, John Wiley, 2000. 8. Fundamentals of Instrumental Analysis, Skoog, D. M. West and F. J. Holler, 8th Edition, Saunders College Publishing (2004). 28 enones and aromatic compounds. Ultraviolet and visible spectroscopy 3h Classification of elecgronic transitions.Resonance condition. Intramolecular interactions. Equivalence of protons-chemical and magnetic equivalence. Organic and Physical Chemistry Students) 52 hours I. Aromatic compounds. Carbonyl compounds and Annulenes.Mechanism of shielding and deshielding in Alkanes. Ketones. resonance. spectrum of ehnaol. AX3. Alcohols.C-304 SPECTROSCOPY – II (Common to Analytical. Alkenes. Acid chlorides. Termperature effects. Mass effect. Empirical rules for calculating λmaxII. Terminology.examples. Alkyl halides. FT-NMR. problems using UV and IR.Bond order. Nitro compounds. UV spectral study of alkenes.Types of CMR spectra-undecoupled. Aromatic compounds. III. Applicaton of IR in the stuy of H-bonding. Applications of 13C NMR Spectroscopy in confirmation of structure and stereochemistry of organic molecules and in determinng the reaction mechanism and dynamic processes of organic reactions. Amines. Simplifications of complex spectras. Relaxation methods. Karplus Curve. Amides. population of nuclear spin levels and NMR isotopes. Pascal’s triangle-low and high resolution. Aldehydes. Diamagnetic and paramagnetic effects and magnetic anisotropy. Complimentarity of IR and Raman. Chemical shift. Nuclear magnetic resonance spectroscopy 15h Introduction. etc.AB types. Problems. 13C chemicals shifts of Alkanes. geminal and long range coupling-Spin decoupling. polyenes. Esters.AX. Substituent and solvent effects. 13 13 29 . Acids. Protons attached to elements other than carbon. Conjugation. Inductive. Spin-spin interactions. Insturmetnation and sample handling. Magnetic properties of nuclei. Spinsystems: First order and second order coupling of AB systems. C NMR and Correlation Spectroscopy: 10h C NMR Spectroscopy. CIDNP. AMX. Inorganic. Steric effects. Vicinal. Carbonyl compounds and aromatic compounds. Alkyl halides. Factors influencing coupling constants and Relative intensities.. Offresonance decouled (SFORD): Selectivity decoupled and gated decoupled spectra. Alcohols. Alkynes. proton decoupled. Identification of the following organic compounds by IR: Alkanes. Group frequencies.AX2. Nuclear spin. Factors affecting the chemical shifts.. Alkenes. Stereochemistry and hindered rotations. Alkenes. Chemical shift reagents and deuterium exchange. Ethers. Vibrational Spectroscopy: spectroscopy 9h Sampling techniques. stereoisomerism and tautomerisam. factors affecting group frequencies. Nuclear Overhauser effect (NOE). Halides. Interpretation of organic mass spectra. Fundamentals of molecular spectroscopy. New York. 1975. 5.A. J. P. Spectroscopic techniques for Organic Chemists. A. Laszlo and P. 2. Mass spectrometry a foundation course. Budzkiewicz. 9. Holden-Day. 1973. Ed. Modern NMR techniques and their Applications. M. M. F. Application of NMR and MS methods and chemical reactions in structureelucidation of organic compounds. 2D-J-resolved spectroscopy. New York. A I Popov. 2004. W. 1969. R. G. 4th edn. Factors affecting cleavage patterns. alcohols. Homonuclear (13C-13CJ).Mass spectrum-molecular ion-types of ions in mass spectra and effects of isotopes on mass spectra. John Wiley. aldehydes. 1986. Harper & Row. P. FAB mass and MALDI methods. R. A. 3rd Edn. nitro and halo compounds peptides. HOMO and HETERO-2D-J-Resolved spectra. MeLafferty and MeLafferty +1 rearrangment. Weber. 2001. Prentice-Hall. London. 15. Kriz. DEPT. alkyl halides. 2005. 1993. W.Mass spectrometry and Composite Prooblems: 8h Basic principles-instrumentation – ion production-ion analysis-magnetic sector instrumentsQuadrapole mass spectrometers. and W. Time of flight mass spectrometers-ion cyclotron resonance spectrometers. acids. 3. Dass & E. Applications of absorption spectroscopy to organic compounds. Instrumental methods of analysis. Organic spectroscopy. L. Cambridge. L J Bellamy. 7h SUGGESTED BOOKS 1. J N S Evans. NY. K Downard. P. Spectrometric identification of organic compounds. Use of HRMS to determine exact molecular formulae of compounds. Composite problems. Modern structural theory of organic compounds. Alkenes. ELBS London. Nitrogen rule. J. Williams. 17. Silverstien. amines. Organic spectroscopy. Kemp. 7. 1975. 12. Fragmentation of: Alkanes. and D. Merrit. 13. 1999. Prentice-Hall. 10. CBS Publishers and Distributors. 14. Settle. John Wiley. Pavia. L. Methods of ionization. I and II. Practical Organic Mass Spectroscopy. Oxford Univ. L. New Delhi. H. Banwell and E. EI. New Delhi. ethers. 8. Dyer. New Delhi. H. J R Chapman. L.Tata McGraw-Hill. The IR Spectra of complex molecules. Ferguson. D. 2000. 4. IBH New Delhi. 1980. K. H. IV. London. NY.. C. Biomolecular NMR Spectroscopy. 1973. 11. 30 . Classification of 2D Experiments. Harcourt College Publishers. Organic mass spectroscopy. Willard. Marcel Deckker. 1971.Introduction to 2D-NMR Pulse sequences. H. Explanation of the principle. esters. 16. 6. Chapman and Hall. McCash. James. Benjamin. Correlation Spectroscopy (COSY). 2nd Edn. W.. ketones. R. Mass spectrometry of organic compounds. and heteronuclear (13C-1H. Vols. N. 1991. 13C-2HJ) couplings. Dean and F. J W Cooper. RSC. Stang. applications to structure elucidation and stereochemistry of simple organic molecules. Introduction to spectroscopy. Djerassi C. 1976. 1995. S. N. McLafferty. Laupman and G. M. Determination of molecular formula. FT-Methods. Preparation of S. 13. New Delhi.B. Ahluwalia. Friedel-Crafts reaction: Benzene and Acetyl chloride. 2000. 11. 10. 20. Estimation of Keto group 10. Cannizarro reaction: Benzaldehyde. Calcutta. Saponification value of oil. Iodine value of oil. p-Bromoaniline from acetanilide. (1996). (1964). 12. 12. 2005. Laboratory manual of Organic Chemistry. An advanced course in practical chemistry. V K Ahluwalia. 17.. Dey. A. 13. 8. 9. Mahapatra and A. M V Sitaraman and T R Govindachari. 2. V. B. Pooja Bhagat and Renu Aggarwal. 15. 2005. Dey. Vogel. I. Nad. I and II. Estimation of amines/phenols by acylation method. Allied Publishers. Text Book of Practical Organic Chemistry. V K Ahluwalia.305 Analytical Chemistry Practical I (Organic Chemistry) I Preparation of one stage compounds 12. 1992. Vogel. Dhingra. 14. 12. I K International Publishing House.K. Estimation of glucose. 15. Universities Press (India). p-Nitroaniline from aniline. B. Test Book of Quantitative Organic Analysis. New Delhi. I. New Delhi. S. 31 . New Delhi. Comprehensive practical organic chemistry : Preparation and quantitative Analysis. 19. Vol. Universities Press (India). Ramesh Chandra and Renu Aggarwal.4-Dinitrophenylhydrazine from chloronitrobenzene. Practical Organic Chemistry – Mann and Saunders.benzylisothiuronium chloride. 16. 18. 16. II Preparation of two and three stage compounds 9. m-Nitrobenzoic acid from methyl benzoate. J. (1996). 14. 11. V. B. 13.A. (1996). 11. Aggarwal. III Quantitative analysis 7. 1992. Mohan. Intermediates for Organic Synthesis. Advanced practical organic chemistry. Laboratory Techniques in Organic Chemistry. M V Sitaraman and T R Govindachari. I K international Publishing House. Anthranilic acid from phthalic acid. A Handbook of Organic Analysis – Clarke and Hayes.K. Himalaya Publishing House.A. 2000. 2000.Kr. Ahluwalia. Pooja Bhagat. Claisen-Schmidt reaction: Acetophenone and Benzaldehyde / acetone and benzaldehyde. Allied Publishers. Practical organic chemistry (Quantitative analysis). Comprehensive practical organic chemistry: Qualitative analysis. B. (1980). Sandmeyer reaction: p-Chlorotoluene from p-toluidine. SUGGESTED BOOKS 11. R.C. Ghoshal. New central book agency. Analysis of Portland cement: Estimation of insoluble residue by gravimetry and CaO by volumetry Analysis of bauxite :Estimation of silica by gravimetry and aluminium by gravimetry Analysis of dolomite: Estimation of CaO and MgO by volumetry Analysis of pyrolusite:Estimation of metallic hydroxides by gravimetry and manganese by volumetry II Alloy Analysis: Analysis of brass: Estimation of copper by gravimetry and zinc by EDTA titration Analysis of bronze: Estimation of copper by volumetry and tin by gravimetry Analysis of type metal: Analysis of lead by volumetry and tin by gravimetry Analysis of chrome steel: Estimation of iron by volumetry and Cr by colorimetry Analysis of mint alloy: Estimation of copper by volumetry and nickel by gravimetry Analysis of hindalium: Estimation of aluminium Analysis of wood’s alloy III Soil Analysis: 13. 2. A Text Book of Soil Chemical Analysis. Zn etc in the soil samples.W.Vogel.ELBS London.I. Hesse CBS.306 Analytical Chemistry Practical – II I Ore Analysis: Analysis of haematite: Estimation of silica by gravimetry and iron by volumetry. Analysis of N. SUGGESTED BOOKS 1.2nd edition . G. K and micro nutrients like Cu. Day and Underwood 32 . 2002. P. Marr and B. 4. Quantitative Inorganic Analysis. Quantitative Inorganic Analysis by A. Van Nostrand Reinhold Co. Rockett. 3. London 1972. Practical Inorganic Chemistry. P.R.C. new Delhi. Case study of calcite. Junctions using superconductors VI Phase Transition in Solids 2h Definitions. order-disorder transitions and spinodal decomposition VII. polyparaphenylene. Optical and Acoustic modes of a crystal.THIRD SEMESTER INORGANIC CHEMISTRY SPECIALISATION C-301 IC SOLID STATE CHEMISTRY 52 hours 1 `Electronic structure of solids 7h Bonding in solids: Ionic. IV. Meisner effect.dielectric properties. Fermi sphere. Defects in Solids Point defects. metal-semiconductor. ionic conductivity applications of band theory to TiO and NiO: Limitations of the Independent electron model. Semiconductors: Intrinsic and extrinsic. Frolich diagram. Type I and type II superconductors. total vibrational energy of a crystal. metallic and molecular solids Free electron theory. covalent. Stacking faults and grain boundaries 2h V Superconductivity 4h Superconductivity. Screw axes and glide planes. Law of Interfacial angle (Euler’s construction). repeat and reduced zone schemes II Electrical and Magnetic Properties of Solids 9h Metals: calculation of density of states. weak paramagnetism. 33 5h and . Line defects and Plane defects. limitations of the free electron theory Electrons in a weak periodic potential (Independent electron model). semiconductorsemiconductor types and transistors Insulators. point groups.metal-metal. Bravais lattices. Fermi-Dirac statistics.polyacetylene. First and second order phase transitions: Martensitic transition.p and n-types. Junctions and their applications. polypyrrole and related materials III Dynamics of Atoms in a Solid 4h Dispersion curves of an elastic structureless medium. origin of resistivity. Longitudinal and Transverse modes. Cooper pairs. Geometric Crystallography Symmetry elements. Hall effect. Classification of phase transitions. modeling electron correlation Organic conductors. space groups and nomenclature. Features of superconductors. energy levels in extended. Theory of low temperature superconductivity. ferroelectric transitions in BaTiO3. Ohm’s law. piezo and inverse piezoelectric effects. ferroelectricity. Principles of the Solid State. Determination of lattice parameters from these methods.Inc and Collier Macmillan Publishers 10. 1972.R. Phase Transitions.M. N. Kinetics and mechanism Labile. New York. V. D. Phase problem and Patterson synthesis.VIII. Electron diffraction: Experimental technique. 5. Acid and Base catalysis: acid catalyzed equation and anation reactions. Oscillation. Physical Chemistry. M. diffraction pattern of a primitive cubic lattice. Ross. Classification of mechanisms-energy profile of reactions having different mechanisms. New Delhi (1980). Lewis and M. trans influence. Cambridge University Press 9. Sherwood. London. P. M.Glusker. Solid State Physics. stable and unstable complexes. L. Mermin. X. Rao.J. 1960. Experimental Methods: 3h Rotation. Fourier synthesis. 2h 2h C-302 IC INORGANIC RACTION MECHANISMS & BIOINORGANIC CHEMISRTY 52 Hrs 1. Weissenberg and Precession methods. Edward Arnold. 2. application of trans effect in the synthesis of new complexes. Kheer. Woolfson. chelate and metal effects. Ewald’s sphere of reflection. M. Wierl equation. New Delhi (1993). McGraw Hill Book Co. Fourier transform of the structure factor.. H. Electron density function. SUGGESTED BOOKS Introduction to Solids. 3h Substitution in square planar complexes: Trans effect. XI. An Introduction to X-ray Crystallography. Scaterring factor and structure factor. theories of trans effect. Crystal Structure analysis for chemists and biologists. Holt Saunders International Ltd. space group extinctions. 6. Cambridge. G. Vibrational Spectroscopy of Solids. Azaroff.Wiley-VCH (1994). Radial-Distribution method. 1973. Debye-Scherrer method (Powder method). Barrow. Reciprocal Lattice concept. intensities from atomic positions for BCC and FCC lattices.. Diffraction theory and Single crystal X-ray diffraction 9h X-rays. New York (1976).P. W. assignment of lines. M. Ashcroft and N. 4. inert. leaving groups. Neutron diffraction: Principle and Theory. W. McGraw Hill (2nd ISE) (1966). Dynamics of Atoms in Crystals. advantages and uses. Cochran.. (pages: 1-45) 8. University Press. C.. X-ray Structure determination: A practical guide. J. Macmillan Publishing Co. Rao and K. 1. 3h Mechanism of ligand substitution in octahedral complexes-kinetics.A. (pages 24-37) 7. Bragg’s law. IX. Cambridge University Press-Vikas Publishing House. 3. V. Wiley Eastern Ltd. 34 . George H Stout and Lyle H Jenson.N. J. crown ethers.L. 2. (1985).D. Isomerisation. peroxidase and cytochrome P-450. transferrin and siderophores. 3h II Introduction to Bioinorganic chemistry Essentials and trace elements in biological processes. vitamin B12.B. Metal ion deficiency. Cytochrome c oxidase 7h Metalloenzymes: Zinc enzymes-carboxypeptidase. Copper enzyme-superoxide dismutase. detoxification. 35 . 2nd edition (1998). Co-C bond cleavage. nitrogenase-bacterial nitrogenase systems and synthetic studies. Brooks/cole publication co. alkylation reaction of methyl cobalamin. Nonporphyrin systems-hemerythrin and hemocyanin.A.mutase activity of coenzyme B12. Inorganic Chemistry. toxicity. Mitochondrial flow of electrons from NADH to oxygen. conjugate base hydrolysis. Application of ligand substitution reactions for the synthesis of new octahedral complexes. xanthineoxidase.Atwood. Coenzymes containing cobalt. outer-sphere electron transfer. Photosynthesis: Structure of chlorophyll. reductive elimination. ionophores. model complexes. dioxygen binding. G. Reaction mechanism of inorganic and organometallic systems. Na+/K+ ion pump. Metal ligand interactions with DNA. Stereochemistry of octahedral substitution. Molybdenum enzymes-oxotransferase enzyme. metal complexes used as anticancer and antiarthritic drugs. 3. carbonic anhydrase and alcohol dehydrogenase. Marcus equation. Inner-sphere electron transfer-one and two electron transfer. Tarr.Jordon. J. 4h SUGGGESTED BOOKS 1. chelation therapy. elements in biological cell. Oxford University press. Importance of Ca2+ in muscle contractions and in blood clotting process. PS I & PS II in cleavage of water. Inorganic and organometallic reaction mechanism. Cytochrome c. 5h Oxidative addition . Metal ion storage and transfer-ferritin. Miessler and D. Structure and functions of metalloproteins in electron transfer process-cytochromes-. 8h Photosynthesis and nitrogen fixation: Nitrogen fixation.base hydrolysis. Iron enzymes-catalase. Use of electron transfer reactions for the synthesis of new complexes. migratory insertion reactions. structure and functions of haemoglobin and myoglobin. ferridoxines and rubredoxines. 6h Electron transfer reactions: complementary and non-complementary. Molecular mechanism of ion transport across cell membranes. 13h Metalloproteins: Transport and storage of dioxygen: Heme proteins and oxygen uptake. biomolecules associated with metal ions and their roles. Pearson education 3rd edition (2007). Compound nucleus theory III Radioactivity 9h Radioactive decay kinetics. Inorganic Chemistry . neutron absorptiometry and age determination. (2007). (1998) Principles of Bioinorganic Chemistry. S.Kotz. 6. Reaction cross section. Inorganic Chemistry. Bioinorganic chemistry. K. radiation damage to solids. 10.Wulfsberg. II Nuclear reactions 7h Fundamentals. electrical quadrupole moment of nucleides. shall Fermi gas model. β+ and γ. J.Purcell and J. 7. Asim K das.Finke. Corpotation (1997).Gray.Nuclear models: :Liquid drop. Conservation and Threshold. insulators and catalysts.J. V Radiation chemistry 9h Interaction of matter with radiation.Collmann. Classification of reactors based on fuel.Lippard and J. Viva Books private Ltd.Ltd. structure determination.Bertini. Bioinorganic Chemistry. 5. alloys. Fuel-moderator-coolant combinations to achieve criticality. J. 8. radioanalysis. radiolysis of water. I. Saunders company.decay. N. S. neutron energy. Fission and Fusion. L.R. Auger effect IV Applications of radioactivity 9h Synthesis of various useful isotopes. the hydrated electron. CANDU reactors: Safety implications (Elective) 36 . semiconductors.M. University Science Books.C. nuclear parity. moderator and coolant types. Radioisotopes in the field of medicine. β-. (1987). Panima Pub.4. Theories of α-. (1977) Principle and Application of Organotransition metal chemistry.F. VI Nuclear reactors 5h Fission energy. free radical generation. nuclear forces and interactions.Secular and transient equilibria. collective model and optical model. Criticality. nuclear statistics. PGNAA. Viva Books Pvt.preparation and properties.M.P.isotope dilution techniques.Norton and R. G. radiation dosimetry-units and measurement using chemical dosimeters.Berg.Lippard & J. (2002).B.S. H. kinetics of exchange reactions.G.J.Valentine. C-303 IC NUCLEAR CHEMISTRY 52 hours I Nuclear properties and models 8h Mechanical effects due to orbiting and spinning of nucleons.Hegedus. Parent-daughter decay-growth relationships. Fermi’s four factor formula. magnetic properties of nucleons. 9. Use of isotopes in elucidation of reaction mechanism.Hussain Reddy. New Age international publications (2003) Bio-inorganic chemistry.S. measurement of physical constants including diffusion constants. Types. NAA. Internal conversion. Books and allied (p) Ltd.effects of radiation on metals. background absorption. Pulse polarography and Amperometry. Kaplan. emission. J. H. zeeman effect. CW voltage multiplier. Essentials of Nuclear Chemistry. Nuclear Chemistry.303 ADVANCED ANALYTICAL TECHNIQUES (Common to Inorganic and Analytical Chemistry) 52 hours 1 Optical spectroscopy methods 15h Atomic spectroscopy. W. ICP characteristics. Cyclotron. methodology and applications: thermogravimetric and differential thermal analysis. photodiodes. differential scanning calorimetry. Wiley-Interscience. principal processes. electrothermal vapourisers. thermometric titrations.VII Particle accelerators 5h Van deGraff generator. 4th Edition NAIL Pub. J. Electrogravimetry. LINACS. 2. and Coulometric titrations. Coulometry. matrix. correction methods. absorption. tourch configuration and view modes. deuterium arc. cold vapour AAS. photoemmissive cells. spectral. Anodic stripping voltammetry. Microwave induced plasma systems in atomic spectrometry. India Book House.N. Source Book on Atomic Energy. principles and differences. Glasstone. Nuclear Physics. S. theory. Currents in Electrochemical cells. Hydrodynamic Voltammetry. radiation sources. Nuclear and Radiochemistry. C . Thermo-mechanical and dynamic mechanical analysis . East West Press. single biomolecule detection and characterization. Instrumentation. Smith-Hieftje methos. sample introduction methods. Interferences. IV Analysis of Biomolecules 9h Introduction. Betatron SUGGESTED BOOKS 1. Kennedy and J. Flame AAS.Sulthan Chand and Sons(1991). Arnikar. Nonflame techniques. M. AES and AFS. Voltammetry. Friedlander. single beam and double beam instruments. PMT. applications of AAS. chemical. HCL. 1995. Voltammetry in Vivo for chemical analysis of nervous system 37 . Polarography. New York (1981). Raman spectroscopy in analysis of biomolecules. TGL etc. EDL. Synchrocyclotron. 3. NMR of biomolecules. mass spectrometry in the analysis of inorganic compounds 8h II Electroanalytical techniques 12h Electrode Potentials. fluorscence techniques.U. GAAS. Inductively coupled plasma optical emission spectrometry. Delhi (1977) 5. J. 4. Miller. I. Fluorescence based biosensors. III Thermal methods of analysis 8h Principle. different types of nebulizers. Dash. Potentiometric titrations. analytical performance. Cyclic voltammetry. mass spectrometry in structural biology. Bombay (1978). evaluation procedures. detectors. New York. Alkenes. Alkynes. Complimentarity of IR and Raman. R. etc.. Termperature effects. FT-NMR. Aromatic compounds. D. A. Christian.SUGGESTED BOOKS 1. Faulkner. 5th edition. population of nuclear spin levels and NMR isotopes. Aromatic compounds. Magnetic properties of nuclei. Ed. 2nd edition. 1989 6. Vogel’s text book of Quantitative Chemical analysis 5th edition. Esters. 38 . Merrit . Carbonyl compounds and Annulenes. Spin-spin interactions. Spinsystems: First order and second order coupling of AB systems. Insturmetnation and sample handling. Meyers Vol. Diamagnetic and paramagnetic effects and magnetic anisotropy. Wiley. Problems. Relaxation methods. 2000. C-304 SPECTROSCOPY – II (Common to Analytical. Bard & l. L. Dean and F. Inductive. Thomson Asia Pvt. Ketones. G. polyenes.Holler and Crouch. Substituent and solvent effects.AB types. Chemical shift reagents and deuterium exchange. Intramolecular interactions. Jeffery et. Karplus Curve. New York.A. By R. Empirical rules for calculating λmaxII. Vibrational Spectroscopy: spectroscopy 9h Sampling techniques. Amides. A. Identification of the following organic compounds by IR: Alkanes.Mechanism of shielding and deshielding in Alkanes. Analytical Chemistry. 3. Pascal’s triangle-low and high resolution. UV spectral study of alkenes.Bond order.Resonance condition. Nuclear magnetic resonance spectroscopy 15h Introduction. G. Steric effects. al ELBS/Longman. Electrochemical methods: A. Willard. Inorganic. Group frequencies. McGraw-Hill. Terminology. Vicinal. Instrumental methods of Chemical Analysis. stereoisomerism and tautomerisam. Eigth Edition. CBS Publishers (1996). Stereochemistry and hindered rotations. Mass effect. 1988. 7. factors affecting group frequencies. Acids.. Alcohols. resonance. Encyclopedia of Analytical Chemistry: Ed. 2000. Ultraviolet and visible spectroscopy 3h Classification of elecgronic transitions. Halides. Chemical shift. H. Alkenes.J. Amines. AMX. Skooj. (1994) 2. Fundamentals of Analytical Chemistry. L. Equivalence of protons-chemical and magnetic equivalence. enones and aromatic compounds.AX. Simplifications of complex spectras. Organic and Physical Chemistry Students) 52 hours I.. 1 – 15. J.West. III. John – Wiley and Sons Inc. W. Ltd(2004). V Edition. Alkyl halides.H. 4. Conjugation. John Wiley. Applicaton of IR in the stuy of H-bonding. Acid chlorides. Instrumental methods of Analysis. Set. problems using UV and IR. spectrum of ehnaol. 5. AX3.AX2. Aldehydes. Nuclear spin. geminal and long range coupling-Spin decoupling. Ewing. Nitro compounds. alkyl halides. Oxford Univ. 6. applications to structure elucidation and stereochemistry of simple organic molecules. 2000. Kriz.examples. Determination of molecular formula. 1993. Composite problems. K. 13C-2HJ) couplings. I and II. J R Chapman. Budzkiewicz. ketones. W.. J. 2001. Biomolecular NMR Spectroscopy. Practical Organic Mass Spectroscopy. acids. Laupman and G. 39 13 . Organic spectroscopy. 13. P. London. RSC. W. Benjamin. H. London. Carbonyl compounds and aromatic compounds. Dyer. M. Methods of ionization. McLafferty. esters. The IR Spectra of complex molecules. Introduction to spectroscopy. New Delhi. New York. Holden-Day. alcohols. 9. Application of NMR and MS methods and chemical reactions in structureelucidation of organic compounds. aldehydes. A. Spectroscopic techniques for Organic Chemists. 2D-J-resolved spectroscopy. Cambridge. Mass spectrometry of organic compounds. 1976. 13C chemicals shifts of Alkanes. New York. J N S Evans. Spectrometric identification of organic compounds. NY. Alkyl halides.MeLafferty and MeLafferty +1 rearrangment. ethers. 3rd Edn. Correlation Spectroscopy (COSY). Mass spectrometry a foundation course. Use of HRMS to determine exact molecular formulae of compounds. Harper & Row. 1995. 12. Alkenes. Djerassi C. P. 5. nitro and halo compounds peptides. and D. ELBS London. Applications of 13C NMR Spectroscopy in confirmation of structure and stereochemistry of organic molecules and in determinng the reaction mechanism and dynamic processes of organic reactions. Williams. EI. John Wiley. Time of flight mass spectrometers-ion cyclotron resonance spectrometers. DEPT. 2005. Factors affecting the chemical shifts. Nuclear Overhauser effect (NOE). Introduction to 2D-NMR Pulse sequences. proton decoupled. S. L. James. Weber. Nitrogen rule. Classification of 2D Experiments. Harcourt College Publishers. 1980. Silverstien. 13 C NMR and Correlation Spectroscopy: 10h C NMR Spectroscopy. 11. FAB mass and MALDI methods. Interpretation of organic mass spectra. Ethers. IBH New Delhi. Explanation of the principle. 10. Factors affecting cleavage patterns. Organic mass spectroscopy. R. H. John Wiley. 2.CIDNP. Dass & E. amines. 7. and heteronuclear (13C-1H. Applications of absorption spectroscopy to organic compounds. Vols. 1971. F. and W. Prentice-Hall.Types of CMR spectra-undecoupled. W. L J Bellamy. 1975. Factors influencing coupling constants and Relative intensities. J W Cooper. G. D. 1973. Protons attached to elements other than carbon. 4. Offresonance decouled (SFORD): Selectivity decoupled and gated decoupled spectra. 3.. 2004. K Downard. Alcohols. P. Laszlo and P. Fragmentation of: Alkanes. R. R. 1969. 8.Mass spectrum-molecular ion-types of ions in mass spectra and effects of isotopes on mass spectra. Stang. 7h SUGGESTED BOOKS 1. Kemp. Homonuclear (13C-13CJ). FT-Methods. 2nd Edn. 1975. Chapman and Hall. Mass spectrometry and Composite Prooblems: 8h Basic principles-instrumentation – ion production-ion analysis-magnetic sector instrumentsQuadrapole mass spectrometers. IV. Pavia. NY. HOMO and HETERO-2D-J-Resolved spectra. Organic spectroscopy. M. Alkenes. Reactivity for aliphatic substrates. Kolbe reaction and Hunsdiecker reaction. II. New Delhi. L. Photochemistry Physical and Chemical processes. oxidation of aldehydes to carboxylic acids. migration of double bonds. Ferguson. Sandmeyer reaction. A. CBS Publishers and Distributors. use of DCC in the formation of anhydrides). reactivity at a bridgehead. M. 18.14. A I Popov. 19. Fundamentals of molecular spectroscopy. C. THIRD SEMESTER ORGANIC CHEMISTRY SPECIALISATION C-301 OC ORGANIC REACTION MECHANISMS 52 Hours 10h I. New Delhi. Electrophilic substitution reactions: SE2. Dean and F. carbene and nitrene insertion. H. McCash. Hydrogen exchange. Modern structural theory of organic compounds. substitution at a vinylic carbon. hydroxylation at an aliphatic carbon. 1999. Marcel Deckker.. Modern NMR techniques and their Applications. Photochemistry of functional groups: 40 11h . N. Free radical reactions: Free-radical mechanisms in general. quantum and chemical yields. photochemical methods. Haller-Bauer reaction. 4th edn. Photosensitization.Tata McGraw-Hill. 20.A. L. 1973. Banwell and E. peresters and azo compounds. Aliphatic nucleophilic and electrophilic substitution reactions Nucleophilic substitution reactions: Substitution at allylic carbon (allylic rearrangement). Neighboring group assistance in freeradical reactions. Willard. reactivity in aromatic substrates. ketones and acids. Halogenation at an alkyl carbon and an allylic carbon. hydroxylation at an aromatic carbon. α halogenation of aldehydes. Prentice-Hall. H. Meerwein arylation. quantum efficiency. Free-radical substitution mechanisms. reactivity in the attacking radical. formation of hydroperoxides and peroxides. Neighboring group participation and SNi reactions. III. Orton reaction. Settle. 1991. Aliphatic diazonium coupling. 1986. Mechanisms at an aromatic substrate. decarboxylation of aliphatic acids. N. at a trigonal carbon (hydrolysis of esters and amides. J. SE1 and SEi mechanisms. nitrosation at carbon bearing active hydrogens. haloform reaction. Free-radical chemistry 10h Generation of free-radicals: Thermal homolysis of peroxides. diazo transfer reaction. L. Gomberg-Bachmann reaction. Merrit. Jablonski diagram. Ed. Instrumental methods of analysis. 4n+2 and allyl systems. 1. Pyridoxal phosphate (PLP) in transamination. Norrish type-I and type-II cleavages. V. John Wiley (2008).sigmatropic rearrangements (including Walk. Coenzyme A (CoASH) in the transfer of acyl group. Biotin and vi). Flavin coenzymes in biological redox reactions SUGGESTED BOOKS 1. Advanced Organic Chemistry – Reactions.3-butadiene. Oxidative coupling of aromatic compounds. ii).β-unsaturated ketones. Tetrahydrofolic acid (H4F) in one-carbon transfer reactions. Vitamin B12 coenzymes in molecular rearrangement reactions and in the synthesis of methionine and methane.5-hexatriene and allyl system. rearrangements. di-π-methane rearrangements (including oxa. ii) Ketones: Excited state of C=O. iv) Photochemical oxidations and reductions: Cycloaddition of singlet molecular oxygen {[2+2]. ix). α. Claisen. vii). Pericyclic reactions 11h Molecular orbital symmetry. Cycloadditions: antarafacial and suprafacial additions. [ω2a + π2s] and [π4s + ω2s]-cheletropic reactions. [2 + 2]-cycloaddition. Paterno-Buchi reaction. Nicotinamide and x). Vitamin KH2 coenzyme in carboxylation reactions.and aza. [2+2] addition. Regio. cycloaddition of benzene. j]. [4+2]-additions}. Biochemical mechanisms 10h Introduction. IV. Cope. 41 . Rearrangement of cyclohexadienones (application in the synthesis of some important natural products). Electrocyclic reactions: conrotatory and disrotatory motions. viii). iii). decarboxylation. 4n. Hetero Diels-Alder reaction. Frontier orbitals of ethylene. Mechanism and Structure. Jerry March.di-π-methane rearrangements). sigmatropic shifts involving carbon moieties. dealdolisation and elimination reactions of amino acids. [πms + πna] and [πms + πns]cycloadditions. enantio and Endo selectivities in Diels-Alder reactions. oxy and aza-Cope rearrangements). iii) Aromatic compounds: Photorearrangement of benzene and its derivatives. i). iv). Woodward-Hoffmann correlation diagrams. FMO and PMO approaches. Reaction of conjugated olefins. 1. v). Sigmatropic rearrangements: suprafacial and antarafacial shifts of H. The mechanistic role of the following in living systems. Lipoic acid in the transfer of acyl group reactions.3. Thiamine pyrophosphate (TPP) in decarboxylation of α-ketoacids and in the formation of α-ketols. [i.i) Olefins: Cis-trans isomerism. photoreduction by hydrogen abstraction. Thiagarajan. Mitsunobu reaction. 1998. 1974. Acid-catalyzed self condensation of olefins. Frontier orbitals and organic chemical reactions. Reagents in organic synthesis Use of the following in organic synthesis and functional group tansformations. D Nasipuri. M. Mechanisms of molecular migrations. Marchand. Oxford. 3. Nelson & M. Stereochemistry of Organic Compounds: Principles and Applications. Pergamon Press. A. Physical and mechanistic organic chemistry. 10. Prins reaction. R. 1979. Ian Fleming. 5. C-302 OC ORGANIC SYNTHESIS 52 Hours I. Stork-enamine synthesis. C. Macmillan. 1st Edn. Giese. Streitweiser. NY. L. Japp. 1998. 6. P. Oxford. Garratt in Comprehensive organic chemistry. N-Nitroaromatic amine rearrangement. Barton and W. Organic photochemistry. Zubey. Deslongchamps. J. J. G. 9. S. 7. New Delhi. B. Press. 42 10h . 1979. Coxon and B. D. Heathcock. 4. 11. Molecular reactions and photochemistry.Klingemann reaction). Streitweiser. London. Principles of Biochemistry. Orbital symmetry.2. C-C and C-N bond forming reactions 13h Darzen's reaction. 1st Edn. Houben-Hoesch reaction. Introduction to organic chemistry A. Press. Hofmann-Martius reaction. 1997. D. Macmillan. L. 8. NY. Voet and J. A. Worth Publishers.Y. Cox. Prentice-hall India. B. Lehr and A. Robinson annulation. Halton. P. Voet. Lehninger. H. Deputy and D. S. Dieckmann cyclization. Jr and C. Chapman. 13. Biochemistry. Cambridge Univ. 15. 16. 1980. Acyloin condensation. R. Understanding organic reaction mechanisms. 2nd Edn. D. amines and nitrite as nucleophiles in substitution. E. 1985. Molecular orbital theory for organic chemistry. Jones. Shapiro reaction. New-Age International. II. Cambridge Univ. Pergamon Press. 14. A. M. Use of nucleophilic nitrogen and electrophilic carbon (NH3. NY. NH3 and amines in addition to ketones and aldehydes) and electrophilic nitrogen and nucleophilic carbon (nitration. Use of acetylides in C-C bond formation reactions. 1979. Fisher-Hepp reaction. Pergamon Press. 1st Edn. 17. Press. John Wiley. 12. Pergamon Press. G. Cambridge Univ. Stereoelectronic effects in organic chemistry. 1969. 1972. 1st Ed. 2005. Hofmann-Loeffler-Freytag reaction. 1972. Biochemistry. Wiley & Sons. 1st Edn. P. Ollis. nitrosation) for the bond formation reactions (including Chichibabin reaction. Academic Press. Skraup synthesis. H. Jacob. (1999).A. 1st Edn. Meyer synthesis. Radicals in organic synthesis. Vols I and II. D. 1st Edn. John Wiley & Sons. 1986. 1983. Deobner-Miller. Organic chemistry Vol. m-CPBA. Cambridge Univ. D. Modern synthetic reactions. A. Vols I & II. 4. New Delhi. 1. 6. Wallis. DCC. Benkeser.Y. Pb (OAc)4. H. LDA. Hantsch and Biginelli reactions. Oxidations 10h Cr (VI) oxidants. farnesol. Ivanov. 4th Edn. K. 1972. K. OsO4. Woodward and Prevost hydroxylation. TMS-chloride. diimide reduction. 1979. A. Pergamon Press. London. Ahluwalia and R. 2nd Edn. Fenton’s reagent. H. Carruthurs. IV. 1st Edn. J.. SeO2. SUGGESTED BOOKS Advanced organic chemistry. 1992. California. Pummer. 1979. properties and applications of CF3COOOH. diazomethane. Baker’s yeast. Finar 6th Edn. 1978. A. momoperphthalic acid) as oxidizing agents. dissolving metal reductions (including Birch. III. Wolf-Kishner reduction. A. 2nd Edn.S. Organic synthesis. Mechanisms of molecular migration. II. D. 1983. limonene. Narosa. 1997. Ag2O. Prentice-hall India. B. W.3-Dithiane (reactivity and umpolung). Macmillan. Barbier. BischlerNapiaralski reactions and Suzuki coupling reaction. Prashar. Terpenoids and Carotenoids Classification. Physical and mechanistic organic chemistry. 3rd Edn. Corey-Bakshi-Shibata and Tishchenko reactions. Longman. Comprehensive organic chemistry. nomenclature. Jr and C. Name Reactions in organic synthesis 9h Studies on the mechanistic aspects and use of the following in organic synthesis: PasseriniUgi reactions. 2005. Streitweiser. Oxford. Raney-Nickel. 7. Willgerdot. Baylis-Hillmann.Ireland. Mn (VII) oxidants. R. Press. I.Lithium iso-propoxide. New Delhi. trimethylsufoxoniun iodide. DMSO. L. Pergamon Press. 9. V. March. dibenzoylperoxide) and peracids (Preparation. Jones. V. Reductions 10h Complex metal hydrides. 1. t-BuOOH. Barton and W. DDQ. Heathcock. Jacob. peroxides (H2O2. DessMartin oxidation. menthols and borneols. O.E. 5. W. Introduction to organic chemistry. 1. Understanding organic reaction mechanisms. Cambridge Univ Press. McMurry reaction. Ritter and Jacobson reactions. House. Stereochemistry of citral. 3. R. 10. Some modern methods of organic synthesis. 43 . organoboranes as reducing agents. Clemmensen reductions). 1985. Benjamin. occurrence and isolation. NBS. Isoprene rules. 2008.8-cineole. C-303 OC CHEMISTRY OF NATURAL PRODUCTS 52 Hours 12h I. 8. Oxford. Organic reaction Mechanisms. catalytic hydrogenation (homogeneous and heterogeneous). ozone. Betti and Robinson-Schopf reactions. Thyagarajan. 2. Correlation of configurations of terpenoids. Cambridge Univ Press. 1975. John Wiley. HIO4. Pheromones in pest control. cocaine. Synthesis of PGE1 and PGE2 by Corey’s and Stork’s approaches. VI. α-terpineol. cinchonine and morphine. v) 3. nucleotides and oligonucleotides. Synthesis of PGE3 by Upjohn’s approach.and γ-carotenes. classification. Biosynthesis of prostaglandins. classification and biological role of prostaglandins. Structure elucidation and synthesis of β-carotene. V. Structural relationship of α-. phosphite triester and phosphoramidite methods. abietic acid. components of nucleic acids. IV. Commercial synthesis of camphor. Structure elucidation and synthesis of nucleosides and nucleotides. occurrence. Prostaglandins 7h Introduction. PGE2 and PGE3. eudesmol. Synthesis of prostacyclin I2 and thromboxane B2. Alkaloids 10h Definition. nucleosides. Structure elucidation and stereochemistry of PGE1. 8h III. Porphyrins and vitamin B12 Structure elucidation and synthesis of haemin. coradyline and tylophorine.11-Dimethy1-2-nonacosanone (pheromone of German cockroaches). Nucleic acids 9h Introduction. General methods of structure elucidation. β-caryophyllene. Photochemical synthesis of Nuciferine. Chemical synthesis of oligonucleotides: Protecting groups for hydroxy group in sugar. α-pinene. Syntheses of (one synthesis should be stereoselective synthesis) i) Grandisol (component of boll weevil pheromone) ii) Farenal (trail pheromone of pharaoh’s ants) iii) Brevicomin (pheromone from Dendroitis brevicomis) iv) (+). hygrine. reserpine and ergotamine. amino group in the base and phosphate functions.Disparlure (gypsy moth sex pheromone). Synthesis and biosynthesis of the following alkaloids: Ephedrine. II. 44 6h . classification.Structure elucidation of camphene. fenchone. isolation. Solid phase synthesis of oligonucleotides. α-santonin and gibberrillic acid. Biosynthesis of squalene and cyclisation of squalene into α-lanosterol and friedelene. Methods of formation of internucleotide bonds: DCC. Synthesis and biosynthesis of the following: Linalool. phosphotriester approach. phosphodiester approach. nomenclature. Structure elucidation and synthesis of papaverine. Insect pheromones Introduction. chlorophyll-a and vitamin-B12 (synthesis of Vitamin-B12 from cobyric acid). nomenclature. Carotenoids: Methods of isolation. coniine. β. vi) Bombykol (sex pheromone of silkworm moth). vii) Multistriatin (Elm bark beetle sex pheromone). SUGGESTED BOOKS 1. Natural products: Their chemistry and biological significance-J. Mann, R. S. Davidson, J. B. Hobbs, D. V. Banthorpe & J. B. Harborne, Longman, UK, 1994. 2. Terpenes, J. Verghese, Tata McGraw-Hill, New Delhi, 1982. 3. Chemistry of terpenes and terpenoids, A. Newman, Academic Press, London, 1975. 4. Handbook of naturally occurring compounds Vol. II: Terpenes, T. K. Davon, A. I. Scott, Academic Press, NY, 1972. 5. Natural products chemistry Vol. I & II, K. Nakanishi, T. Goso, S. Ito, S. Natori & S. Nozoe, Academic Press, NY, 1974. 6. Total synthesis of natural products Vol. I & VI, Apsimon, John Wiley, NY, 1973-1981. 7. Organic chemistry Vol.II, I. L. Finar, 6th Edn. Longman, 1992. 8. Chemistry of natural products Vol. I & II, O. P. Aggarwal, Goel Publishing House, 6th Edn. 1982. 9. Total synthesis of natural products: The chiral approach Vol.III, S. Hanessian Pergamon Press, 1983. 10. Total synthesis of steroids, Akhaun & Titov, Jerusalem, 1969. 11. Medicinal natural products: A biosynthetic approach, P. M. Dewick. John Wiley, Chichester, 1997. 12. The colours of life: An introduction to the chemistry of porphyrins and related compounds, L. R. Milgrom, Wiley Chichester, 1995. 13. Interpretation of the UV spectra of natural products, A.I. Scott, Pergamon Press, Oxford, 1964. 14. Spectral data of natural products Vol. I- K.Yamaguchi, Elsevier Publishing Co, London, 1970. 15. Chemistry of natural products: A unified approach, N. R. Krishnaswamy, University Press, India, 1999. C-304 SPECTROSCOPY – II (Common to Analytical, Inorganic, Organic and Physical Chemistry Students) 52 hours I. Ultraviolet and visible spectroscopy 3h Classification of elecgronic transitions, Terminology, Substituent and solvent effects, UV spectral study of alkenes, polyenes, enones and aromatic compounds. Empirical rules for calculating λmaxII. Vibrational Spectroscopy: spectroscopy 9h Sampling techniques, Group frequencies, factors affecting group frequencies,Bond order, Mass effect, Conjugation, Inductive, resonance, Steric effects. Intramolecular interactions. Applicaton of IR in the stuy of H-bonding, stereoisomerism and tautomerisam. Complimentarity of IR and Raman. Identification of the following organic compounds by IR: Alkanes, Alkenes, Alkynes, Aromatic compounds, Aldehydes, Ketones, Alcohols, Acids, Acid chlorides, Amides, Amines, Esters, Halides, Nitro compounds, etc., problems using UV and IR. 45 III. Nuclear magnetic resonance spectroscopy 15 h Introduction, Magnetic properties of nuclei- Resonance condition. Nuclear spin, population of nuclear spin levels and NMR isotopes, Relaxation methods. Insturmetnation and sample handling, FT-NMR. Chemical shift- Mechanism of shielding and deshielding in Alkanes, Alkyl halides, Alkenes, Aromatic compounds, Carbonyl compounds and Annulenes. Pascal’s triangle-low and high resolution, spectrum of ehnaol. Karplus Curve, Diamagnetic and paramagnetic effects and magnetic anisotropy. Equivalence of protons-chemical and magnetic equivalence. Spinsystems: First order and second order coupling of AB systems, Simplifications of complex spectras. Problems. Spin-spin interactions- AX,AX2, AX3, AMX,AB types. Vicinal, geminal and long range coupling-Spin decoupling. Chemical shift reagents and deuterium exchange. Stereochemistry and hindered rotations. Termperature effects. CIDNP, Nuclear Overhauser effect (NOE)., Factors influencing coupling constants and Relative intensities. Protons attached to elements other than carbon. 13 C NMR and Correlation Spectroscopy: 10 h C NMR Spectroscopy- Types of CMR spectra-undecoupled, proton decoupled, Offresonance decouled (SFORD): Selectivity decoupled and gated decoupled spectra. 13C chemicals shifts of Alkanes, Alkyl halides, Alkenes, Alcohols, Ethers, Carbonyl compounds and aromatic compounds, Factors affecting the chemical shifts. Applications of 13C NMR Spectroscopy in confirmation of structure and stereochemistry of organic molecules and in determinng the reaction mechanism and dynamic processes of organic reactions- examples. Introduction to 2D-NMR Pulse sequences. FT-Methods. Classification of 2D Experiments. 2D-J-resolved spectroscopy. HOMO and HETERO-2D-J-Resolved spectra. Correlation Spectroscopy (COSY). Homonuclear (13C-13CJ), and heteronuclear (13C-1H, 13C-2HJ) couplings, DEPT. Explanation of the principle, applications to structure elucidation and stereochemistry of simple organic molecules. IV. Mass spectrometry and Composite Prooblems: 8h Basic principles-instrumentation – ion production-ion analysis-magnetic sector instrumentsQuadrapole mass spectrometers. Time of flight mass spectrometers-ion cyclotron resonance spectrometers- Mass spectrum-molecular ion-types of ions in mass spectra and effects of isotopes on mass spectra. Methods of ionization, EI, FAB mass and MALDI methods. Fragmentation of: Alkanes, Alkenes, alkyl halides, alcohols, aldehydes, ketones, acids, esters, ethers, amines, nitro and halo compounds peptides, Nitrogen rule, Factors affecting cleavage patterns.MeLafferty and MeLafferty +1 rearrangment. Determination of molecular formula. Composite problems. Use of HRMS to determine exact molecular formulae of compounds. Application of NMR and MS methods and chemical reactions in structureelucidation of organic compounds. 7h 46 13 SUGGESTED BOOKS 1. Applications of absorption spectroscopy to organic compounds, J. R. Dyer, Prentice-Hall, New Delhi, 1969. 2. Organic spectroscopy, P. Laszlo and P. Stang, Harper & Row, New York, 1971. 3. Organic spectroscopy, W. Kemp, ELBS London, 2000. 4. Spectrometric identification of organic compounds, R. M. Silverstien, and W. P. Weber, 2005. 5. Introduction to spectroscopy, 3rd Edn., D. L. Pavia, G. M. Laupman and G. S. Kriz, Harcourt College Publishers, 2001. 6. Organic mass spectroscopy, K. R. Dass & E. P. James, IBH New Delhi, 1976. 7. Interpretation of organic mass spectra, F. W. McLafferty, W. A. Benjamin, London, 1973. 8. Practical Organic Mass Spectroscopy, 2nd Edn. J R Chapman, John Wiley, NY, 1993. 9. The IR Spectra of complex molecules, Vols. I and II, L J Bellamy, Chapman and Hall, London, 1975. 10. Spectroscopic techniques for Organic Chemists, J W Cooper, John Wiley, NY, 1980. 11. Biomolecular NMR Spectroscopy, J N S Evans, Oxford Univ. 1995. 12. Mass spectrometry a foundation course, K Downard, RSC, Cambridge, 2004. 13. Mass spectrometry of organic compounds, H. Budzkiewicz, Djerassi C. and D. H. Williams, Holden-Day, New York, 1975. 14. Modern NMR techniques and their Applications, Ed. A I Popov, Marcel Deckker, 1991. 15. Modern structural theory of organic compounds, L. N. Ferguson, Prentice-Hall, New Delhi, 1973. 16. Instrumental methods of analysis, H. H. Willard, L. L. Merrit, J. A. Dean and F.A. Settle, CBS Publishers and Distributors, 1986. 17. Fundamentals of molecular spectroscopy, 4th edn., C. N. Banwell and E. M. McCash,Tata McGraw-Hill, New Delhi, 1999. THIRD SEMESTER PHYSICAL CHEMISTRY SPECIALISATION C-301 PC CHEMISTRY OF SOLIDS AND DIFFRACTION METHODS 52 hours 1 Electronic structure of solids: 7h Free electron theory, Zone theory, band theory, Fermi sphere, Fermi-Dirac statistics, Ohm’s law, limitations of the free electron theory, Electrons in a weak periodic potential, energy levels in extended, repeat and reduced zone schemes II Electrical and Magnetic Properties of Solids: 8h Metals: calculation of density of states, origin of resistivity, weak paramagnetism Semiconductors: Intrinsic and extrinsic- p and n-types, Hall effect, Junctions and their applications- metal-metal, metal-semiconductor, semiconductor-Semiconductor types and transistors Insulators- dielectric properties, piezo and inverse piezoelectric effects, Ferroelectricity, ferroelectric transitions in BaTiO3, ionic conductivity. Magnetic properties: classification of materials, cooperative phenomena, Magnetic domains, hysteresis 47 2. V. Introduction to Solids. Weissenberg and Precession methods. experimental procedures. Geometric Crystallography : 5h Symmetry elements. X . D. Experimental technique. McGraw Hill Book Co. Rotation.. Junctions using superconductors V Solid State Reactions: 4h General principles. Advantages of Neutron diffraction. 1960. Fourier transform of the structure factor. kinetics of solid state reactions. Ramachandran diagram. Frolich diagram. Electron density function. First and second order phase transitions: Martensitic transition. N. phase problem. IX. Type I and type II superconductors. Oscillation. Azaroff. 48 . photoconduction and photoelectric effects III Crystal Defects and Non-Stoichiometry : Point defects. co-precipitation as a precursor to solid state reactions.Optical properties: optical reflectance. Meisner effect. Ashcroft and N. Miller indices. SUGGESTED BOOKS: 1. Solid State Physics. Determination of lattice parameters from these methods. Bragg’s law. X-ray Diffraction : 12h X-rays. Line defects and Plane defects. VI Phase transition in Solids: 4h Definitions.. absolute configation of molecules. Wierl equation (no derivation). Bravais lattices. Scaterring factor and structure factor and its relation to intensities and electron density. order-disorder transitions and spinodal decomposition VII. Holt Saunders International Ltd. Reciprocal Lattice concept. Law of Interfacial angle (Euler’s construction). Electron diffraction: 3h Scattering intensity and scattering angle. Radial-Distribution. Debye-Scherrer method of X-ray structural analysis. Classification of phase transitions. New York. point groups. W. Indexing of reflection identifiycation of unit cells from systematic absences . VIII . Screw axes and glide planes. Theory of low temperature superconductivity. Fourier synthesis.Neutron diffraction: 3h Scattering of Neutrrons by solids. DebyeScherrer method (Powder method). L.. elucidation of structure of simple gas phase molecules. laue method. Cooper pairs. Mermin. and space groups and nomenclature. magnetic scattering measurements technique. Stacking faults and grain boundaries 2h IV Superconductivity : 4h Superconductivity. Bragg method. New York (1976). Features of superconductors. two photon absorption spectroscopy. R West. Ross. Interaction between light and matter. New Delhi (1993). life times of excited electronic states of atom and molecules. Intensity of electronic transition: Theoretical absorption intensity. Experimental techniques of detection of intermediates. units and dimensions. Spectroscopic terms for electronic state. J.J. Hannay.R. Excited state acidity constants pk* values. Measurment of light intensity. Rules governing transition between two energy levels: Basis of selection rules. 7.. Physical properties of the electronically excited molecules: 10h Nature of changes on electronic excitation. Principles of the Solid State. Diatomic and polyatomic molecules. Particle nature of radiation. Rao. M.P. 11.3. Orbital symmetry and molecular symmetry. Lewis and M. C. C-302 PC PHOTOCHEMISTRY 52hours I.Inc and Collier Macmillan Publishers Solid State Chemistry and its applications. Fates of excited species. Macmillan Publishing Co. time resolved experiments . electronic energy states of atom. Types of chemical reactions: Photodissociation. New Delhi (1987) Phase Transitions. Directional nature of light absorption. Induced pre dissociation II. 6. B. New Delhi (1980). N. Non crossing rule of Teller Emission spectra. Kheer. 8.Wiley-VCH (1994). Excited state dipole moment. potential energy diagram. Wigner’s spin correlation rule 49 . Introduction to Solid State Physics. Cambridge University Press-Vikas Publishing House. wavelength of radiation. Excited state redox potential. Woolfson. Al:Omar. A. 1994. V. Photochemistry and spectroscopy. Introduction to Photochemistry: 10h Importance of photochemistry. 10. Mechanism of absorption and emission of radiation of photochemical interest: 12h Electric dipole transition.N.Glusker.. predissociation. C. Laws of photochemistry. Selection rules for molecular transitions. Transition moment integrals and correlation with experimental quantities. M. Strength of an electronic transition. Wiley Eastern Ltd. light sources. M. Solid State Physics. An Introduction to X-ray Crystallography. 4. Kittel. Crystal Structure analysis for chemists and biologists. Quantum yields. modification of selection rules. The selection rules. H. III. 5. Wiley Eastern Ltd. Cambridge University Press X-ray Structure determination: A practical guide. Environmental effect on absorption and emission spectra. Dual nature of radiation. Rao and K. Types of electronic transition of organic molecules. George H Stout and Lyle H Jenson. John Wiley & Sons 2990 Solid State Chemistry. shapes of absorption bands and Franck Condon principle. 9. Einstein’s treatment of absorption and emission phenomenon. Notation for excited states of organic molecules and Energy levels for inorganic complexes. Woodward-Hoffmann’s rule of electro cyclic reaction. LCAO-MO approximation. Transition metal complexes.W Adamson and P D Fleischaves Wiley.Rohatgi Mukhergee. application to hydrogen molecule ion (H2+). Carol E Wayne and Richard P Wayne.K. C H Deputy and D S Chapman. theories.IV. electron distribution. ion-covalent resonance and 50 . Organic and Inorganic photochemistry: 10h Reaction in compounds containing carbonyl groups photo reduction and related reaction. unsaturated molecules with conjugated system of double bond. normalization and overlap integrals. energy levels for inorganic complexes. exchange. Wiley Physical Chemistry. Cambridge University Press (Ist Edition) (1974) Molecular Reactions and photochemistry. P W Atkins. solar energy conversion and storage. secular determinants. Prentice -Hall India.Types of photo physical pathways. fluorescence emission. ionic terms. photocatalysis. John Wiley and Sons (1991) Organic Photochemistry. potential energy diagrams. J M Cozen and B Halton. electron distribution. V. bonding and anti-bonding molecular orbitals. chemiluminescence’s. Molecular orbital (MO) theory. Comparison of V. Elements of Inorganic Photochemistry G J Ferranti. energy levels. the Heitler-London method. Some current topics: Photoelectrochemistry. triplet states and phosphorescence emission. Lasers excimers and exciplexes. photocyclo addition reactions. 3h D. and M. Quenching and collision deactivation. Wiley Eastern Limited (1986) Photochemistry. coulombic.O. fractional ionic character and its importance. secular equations. Oxford University Press (1996) Introduction to Semiconductor Materials and devices M S Tyagi. New Delhi (1st Edition). Equivalence of simple MO and VB methods. Introductory aspects: Linear and non-linear variation functions. QUANTUM CHEMISTRY Theories of Valence A. K. radiation less transition-internal conversion and intersystem crossing. energy levels of H2+. Julio de Paula ELBS 7th Edition (2002) C-303 PC QUANTUM CHEMISTRY & SURFACE CHEMISTRY (Elective) 52 hours I. A. Various modifications of the Heitler-London wave function. 1972. comparison of theoretical and experimental values of energy. Photo physical process: 10h Jablonski diagram. The Rayleigh-Ritz method. 3h C. Valence bond theory of H2 molecule. emission property and the electronic configuration state diagram. REFERENCES: 1 2 3 4 6 7 8 9 Fundamentals of photochemistry. Concepts of Inorganic Photochemistry. Stern-Volmer plot. 2h B.B. Notation for excited states of organic molecules. noncrossing rule. Harkins-Jura method. Radio active tracer method and Benton and White method. Potential energy curves for adsorption. Rates of desorption. Determination of entropy of adsorption. STM and TEM. Importance of surface area. Kinetic effects of surface heterogeneity. cyclopropenyl radical. Introductory: Review of adsorption curves. Molecular orbital configuration of homo. Few examples of hybridization involving d-orbitals Localised and non-localised molecular orbitals in polyatomic molecules (H2O). Measurements of heat of adsorption (Calorimetric and ClausiusClapeyron method). Correlation diagrams. butadiene. Application to ethylene. 8h E. sp2 and sp3 hybrid orbitals. Mechanism of some catalyzed surface reactions.configuration interaction. notation of molecular orbitals. Adsorption forces. Polarization theory. Kinetic effects of interactions. full notation. allyl radical. Huckel molecular orbital theory: Outline of the method including assumptions. Field Emission microscopy. Langmuir-Rideal mechanism. hybridization. Transition state theory of surface reactions. Surface structure: Surface mobility. Brief description of CNDO. πmobile bond order and free valence. 5h B. LCAO forms of simple wave function and molecular orbitals. 2h C. Rideal-Eley mechanism and their comparison. Langmuir-Hinshelwood Mechansim. diagrams. isoelectronic systems. Measurement of adsorption isotherms (Volumetric and Gravimetric methods). Introduction to extended Huckel method. Heat of adsorption. Kinetics of adsorption: Kinetics of chemisorption (Hertz-Knudsen equation). 5h II. Competitive adsorption. adsorption indicators. Expressions for hybrid orbitals in terms of wave functions of s and p orbitals and explanation of directed valences of sp. 4h F. Surface heterogeneity. 10h 51 . Adsorption-desorption. Mulliken notation. Surface area and its determination by point-B method. Molecular electronic terms. 10h D. stability and magnetic behaviour of molecules from M. Bond order. Calculation of delocalization energy. Electrostatic adsorption. Scanning electron microscopy (SEM). Chemisorptive bond. cyclobutadiene. Low energy electron diffraction method (LEED method). LCAO treatment of diatomic molecules. Directed valence.and hetero-nuclear diatomic molecules.O. Examination of surfaces by Interferometer method.Types. SURFACE CHEMISTRY A. Auger electron spectroscopy (AES). Applications of adsorption. bicyclobutadiene and benzene. Hysteries of adsorption. Adsorption theories: Polanyi’s potential theory. Kinetics of bimolecular surface reactions. The HF-SCF-LCAO method. INDO and NDDO methods. charge density. Mechanistic significance of entropy. Conjugation and hyperconjugation. Harper International edn. K. 8. Electron affinities. Advanced techniques in PMO and FMO theory Molecualr mechanics. Solvent effects. W. allyl and butadiene. Hammond’s postulate. Levine. 2nd edn. Orbital interaction diagrams.Atkins and R. Academic Press.. MO energy levels. Orbital symmetry. allyl. New York (1967). 4. J. Curve-crossing model-nature of activation barrier in chemical reactions. Quantum Chemistry by R. Walter and Kimball. Tunneling effect. Valence bond (VB) configuration mixing diagrams. Relationship between VB configuration mixing and resonance theory. 9. 3rd edn. London (1961). methane and methyl group. Laidler. Interscience Publishers Inc. KINETIC ISOTOPE EFFECT: Theory of isotope effects. C-303 PC PHYSICAL ORGANIC CHEMISTRY (Elective) 1 52 hours CONCEPTS IN MOLECULAR ORBITAL (MO) AND VALENCE BOND (VB)THEORY Introduction to Huckel molecular orbital (MO) method as a means to explain modern theoretical methods. Bell-Evans-Polanyi principle. New York (1944).(1987). 6. Molecular Quantam Mechanics. Chandra.SUGGESTED BOOKS 1. 15h II PRINCIPLES OF REACTIVITY A.S.. Tata McGraw Hill (1994). Prasad. Text book of Physical Chemistry by S.. enthalpy and Gibb’s free energy.. Valence by C. Adamson. butadiene. 10 Quantum Chemistry by Eyring. Surface Chemistry : Theory and Applications by J. Qualitative MO theory – ionization potential. Potential energy surface model. Oxford University Press(1997) Physical Chemistry of Surfaces by A. Reaction profiles. New Jersey (1991). Scope and limitations of several computational programmes. Glasstone. Quantitiative MO theory – Huckel molecular orbital (HMO)method as applied to ethane. John Wiley. MO of simple organic systems such as ethane. ELBS.. Chemical Kinetics by K.W. B. Prentice Hall. Bikerman. McMillan India Ltd. 52 . Marcus theory of electron transfer Reactivity and selectivity principels. Potential energy diagrams.. 2. Transition state theory. A.Friedman. New York (1972). Aromaticity. J. 7. Arrhenius equation. 5. 3. Introductory Quantum Chemistry by A. P.(1986). New Age International (2000). Quantum Chemistry by Ira N. Uses of activation parameters. Coulson. K. semi empirical methods and ab into and density functional methods. Heavy atom isotope effects. 2nd edn. Primary and secondary kinetic isotope effects. C. The Taff model. Structural effects on rates and selectivity. spectroscopic properties and scales for specific salvation. Intermolecular forces. bond dissociation enthalpy. specificity and periselectivity in pericyclic reactions. IX RADICAL AND PERICYCLIC REACTIVITY Radical stability. dispersion and 53 . Deviations from Hammett equation.specific and general catalysis. Thermodynamic measure of salvation. Molecualr measurements of steric effects upon rates. Winstein-Holness and Curtin-Hammett Principle. Reactivity. Ambivalent nucleophiles. Effects of salvation on reaction rates and equilibria. O1 – and OR-Scales. Bronsted catalysis. D. Electrophilic reactivity. Dual-parameter correlations. Electron transfer nature of SN2 reaction. induction. SOLVATION AND SOLVENT EFFECTS Qualitative understanding of solvent-solute effects on reactivity. Molecualr and bond polarizability. Catalysis by non-covalent binding-micellar catalysis. Nucleophilicity and Sn2 reactivity based on curve. Solvent effects. theories of substituent effects. entropy. Electrostatic. VIII NUCLEOPHILIC AND ELECTROPHILLIC REACTIVITY Structrual and electronic effects on Sn1 and Sn2 reactivity. factors effecting barrier heights in additions. Various empirical indexes of salvation based on physical properties. solvent and steric effects. Acid-base catalysis. Use of salvation scales in mechanistic studies. Confromational barrier to bond rotation-spectroscopic detection of individual conformers. Steric acceleration. 14h X SUPRAMOLECULAR CHEMISTRY Properties of covalent bonds – bond length. Reaction constant p. Acyclic and monocyclic systems. A curve crossing approach to radical addition. general mechanism Kinetic of SE2-Ar reaction. ELECTROPHILES. acidity and basicity. Intramolecular assistance. polar influences. inter-bond angles. NUCLEOPHILES AND CASTALYSIS: Acid-base dissociation. Steric LEER.crossing model. III VII STERIC AND CONFORMATIONAL PROPERTIES Various type of steric strain and their influence on reactivity. Electronic and structural effects. Nucleophilicity scales. hydrophobic effects. 14h ACIDS. Hard and soft acids and bases. bond and molecular dipole moments. SRN1 mechanism. Kinetic isotope effects. BASES. inductive substituent constant. substituent constants. Solvent-sensitive reaction rates. Curve-crossing approach to electrophilic reactivity. Solvent effects from the curve-crossing model.Acidity functions and their applications. STRUCTURAL EFFECTS ON REACTIVITY Linear free energy relationships (LFER). Relationship between plar and electron transfer reactions. force constant. Interpretation of o-values. Rotation around partial double bonds. The Hammett equation. Nucleophilic and electrophilic catalysis. regioselectivity in radical reactions. The ά-effect. Nucleofugacity. cyclodextrines. medium effects. polyenes. Mechanism and Theory in Organic Chemistry.U. problems using UB and IR.S. FTNMR. stereoisomerism and tautomerisam. population of nuclear spin levels and NMR isotopes. Principles of molecular association and organization as exemplified in biological macromolecules like enzymes. Organic and Physical Chemistry Students) 52 hours 1.Richardson. Conjugation.C. J M Lehn. W. N. Nuclear spin. nucleic acids.Allinger. Halides. Insturmetnation and sample handling. ELBS/Longman. ACS Monograph 177. H. Molecualr channels and transport processes. Magnetic properties of nuclei-Resonance condition.Maskill.resonance energy magnetic interactions. Steric effects. C-304 SPECTROSCOPY – II (Common to Analytical. Complimentarity of IR and Raman. 3.Lowry and K. Amides. Esters. Supramolecular Chemistry: Concepts and Perspectives. magnitude of interaction energy. Mass effect. Applicaton of IR in the stuy of H-bonding. Vibrational Spectroscopy: spectroscopy 9h Sampling techniques. Relazation methods.B Smith. VCH. resonance. Intramolecular interactions. BVOnd order.L. Molecualr devices and nanotechnology. Oranic Chemists’Book of Orbitats. forces between macroscopic bodies. Hydrogen bond.H. Physical Organic Chemisty. etc. Ultraviolet and visible spectroscopy 3h Classification of elecgronic transitions. Inductive.Jorgensen. Acid chlorides. Cyclophanes. Terminology. Group frequencies.Salem and W. UV spectral study of alkenes. Identification fo the following organic compounds by IR: Alkanes. enones and aromatic compounds. Harper and Row Introduction to Theoretical Organic Chemistry and Molecular Modeling. Amines. Aldehydes. Alcohols.L. Nuclear magnetic resonance spectroscopy 15h Introduction. Academic Press. Molecular receptors and design principles . Alkenes. Cryptands.Burker and N.Empirical rules for calculating λmax2. T. Substituent and solven effects. 54 . VCH The Physical Basis of Organic Chemistry. Nitro compounds.Isaacs. KEtones. Inorganic. Calixeranes.. Alkynes. factors affecting group frequencies.Oxford University Press. L. 9h SUGGESTED BOOKS 1 2 3 4 5 6 7 Molecular Mechnics. Aromatic compounds. Acids. Supramolecular reactivity and catalysis. 1882. membranes and model systems like micelles and vesicles. Weinheim. Use of HRMS to determine exact molecular formulae of compounds. Carbonyl compounds and aromatic compounds. Mass spectrometry and Composite Prooblems: 8h Basic principles-instrumentation – ion production-ion analysis-magnetic sector instrumentsQuadrapole mass spectrometers. Introduction to 2D-NMR Pulse sequences. Alcohols.13C-2HJ) couplings. 4. spectrum of ehnaol.Chemical shift. AMX. Applications of 13C NMR Spectroscopy in confirmation of structure and stereochemistry of organic molecules and in determinng the reaction mechanism and dynamic processes of organic reactions. P. ELBS London. Ethers. Methods of ionization. amines. 2. Aromatic compounds. W. esters. 1969. Carbonyl compounds and Annulenes. Pascal’s triangle-low and high resolution. Protons attached to elements other than carbon. 13C chemicals shifts of ALkanes. Laszlo and P. Factors affecting the chemical shifts. applications to structure elucidation and stereochemistry of simple organic molecules. Harper & Row. 55 . Offresonance decouled (SFORD): Selectivity decoupled and gated decoupled spectra. Alkyl halides. 2000. ketones. Kemp. 3. MeLafferty and MeLafferty +1 rearrangment. ethers. Correlation Spectroscopy (COSY). Applications of absorption spectroscopy to organic compounds. Chemical shift reagents and deuterium exchange. Homonuclear (13C-13CJ). Nitrogen rule. nitro and halo compounds peptides. proton decoupled. Problems. Determination of molecular formula.AB types. Organic spectroscopy.Mechanism of shielding and deshielding in ALkanes. Nuclear OVerhauser effect (NOE). alcohols. Factors affecting cleavage patterns. Explanation of the principle.Mass spectrum-molecular ion-types of ions in mass spectra and effects of isotopes on mass spectra. Vicinal. Classification of 2D Experiments.AX2.AX. Simplifications of complex spectras. CIDNP.Types of CMR spectra-undecoupled. AX3. Stang. Application of NMR and MS methods and chemical reactions in structure elucidation of organic compounds. 7h 13 SUGGESTED BOOKS 1. Equivalence of protons-chemical and magnetic equivalence. 2D-J-resolved spectroscopy. Termperature effects.FAB mass and MALDI methods. Stereochemistry and hindred rotations. aldehydes. DEPT. geminal and long range coupling-Spin decoupling. alkyl halides. acids. Prentice-Hall. Dyer. J. FT-Methods. HOMO and HETERO-2D-J-Resolved spectra. Fragmentation of: ALkanes. Diamagnetic and paramagnetic effects and magnetic anisotropy. Organic spectroscopy. Time of flight mass spectrometers-ion cyclotron resonance spectrometers. Spin-spin interactions. Spinsystems: First order and second order coupling of AB systems. 13 C NMR and Correlation Spectroscopy: 10h C NMR Spectroscopy. 1971. Alkenes. Karplus Curve. and heteronuclear (13C-1H. EI. Alkenes. Alkyl halides. R. Factors influencing coupling constants and Relative intensities.. Alkenes. Composite problems.examples. New Delhi. New York. The IR Spectra of complex molecules. Marcel Deckker. L. Merrit. 17. Pavia. L. Organic mass spectroscopy. London. 3rd Edn. 1980. Cambridge. A. Newcombe. M.. John Wiley. Modern NMR techniques and their Applications. R. 2001. 2004. 8.A. Spectroscopic techniques for Organic Chemists. 4 1/2 hours a day) Analytical Chemistry Practicals C 305 – Physical Chemistry Practical I 1. 7. H. Williams. Introduction to spectroscopy. (1981) Methods of Soil Analysis Part I & II. 12. 9. House. K. 1975. M. L J Bellamy. Biomolecular NMR Spectroscopy. Mass spectrometry a foundation course.A. 15. L. 2nd Edn. Laupman and G. N. New Delhi. 4th edn. Organic. Science Book Agency. Kriz. W. Willard. Weber. and W. Ferguson.Tata McGraw-Hill. Banwell and E. Practical Organic Mass Spectroscopy. N. 5. I and II. Modern structural theory of organic compounds. IBH New Delhi. Experimental Physixcal Chemistry by Wilson. Benjamin. K Downard. Oxford Univ. A. Mass spectrometry of organic compounds. Dass & E. R. D. Black et al (Ed) American Society of Agronomy. John Wiley. Physical and Analytical chemistry practicals (4 days a week. Denaro and Rickett. 13. 14. 1973. L. C. RSC. H. 1999. C. 4.. 1995. 11. H. H. 1976. S. McCash. F. Prentice-Hall. James. 1975. Dean and F. 3. Inc 56 . Settle. Djerassi C. Pergamon Press. 1986. Ed. J W Cooper. McLafferty. (1962) Practical Physical Chemistry by Palit and De. P. A I Popov. 6. and D. NY. W. London. New York. J R Chapman. Goel Pub. P. Interpretation of organic mass spectra. NY. J N S Evans. Fundamentals of molecular spectroscopy. M. Holden-Day. CBS Publishers and Distributors. 2. Calcutta ( 1974) Advanced Physical Chemistry by J B Yadav. J. G.4. 1973. Budzkiewicz. 10. Harcourt College Publishers. Chapman and Hall. Vols. Instrumental methods of analysis. Spectrometric identification of organic compounds. Silverstien. 1991. 1993. New Delhi. C 305 and 306 Practicals Inorganic. 16. 2005. reflective index detector. nuclear statistics.. nuclear parity. structure determination. merits and applications. II. free radical generation. intensities from atomic position. nuclear forces and interactions. Part C: Radiation Chemistry 7h Interaction of matter with radiation. experimental technique. radiolysis of water. 57 . Ion exchange chromatography:Principle-types of stationary phases-applications Size exclusion and affinity chromatography:Principle and size effects. Determination of lattice parameters. radiation dosimetry-units and measurements using chemical dosimeters. Debye-Scherrer method (powder method).MS-chromatography with chiral phases. Nuclear models: liquid drop. Super critical fluid chromatography and extraction:Principle. neutron absoptiometry and age determination. ion pair chromatography-HPLC. Using these methods. semiconductors. Diffraction theory & Practice 15h Diffraction: X-ray. Fermi gas model. Rotation. collective model and optical model. applications. radio analysis-isotope dilution techniques. Electron diffraction. Wierl equation Radial-Distribution method. diffraction pattern of a primitive cubic lattice. radio isotopes in field of medicine. Part B: Applications of Radioactivity 9h Synthesis of various useful isotopes. space group extinctions. measurement of physical constants including the diffusion constants. PGNAA. electrochemical detector)-mobile phase selection. Weissenberg and Precession methods. NAA. kinetics of exchange reactions. applications. Advanced Radioanalytical methods: 6h Part A: Nuclear properties and models Subatomic particles: protons. alloys. III. Oscillation. scattering factor and structure factor. Bragg’s law.. Electrophoresis and electro chromatography: Principle and instrumentation iso electrophoresis-capillary zone electrophoresis. quarks. radiation damage to solids-effects of radiation on metals. the hydrated electron-precipitation and properties. electrical quadrupole moment of nuclides. assignment of lines. instrumentation. spin and magnetic properties of nucleons. insulators and catalysts . use of isotopes in the elucidation of reaction mechanism. shell model. neutrons. Advanced Separation Techniques 15 h High Performance Liquid Chromatography: Principle-instrumentation-sample injection detectors (absorbance detector.FOURTH SEMESTER (Analytical Chemistry Specialisation) C-401 AC INSTRUMENTAL METHODS OF ANALYSIS 52 h I. J. sodium. conductivity.D. New Delhi Instrumental method of analysis. hardness.Macmillan Publishing Co. II Water Pollution Origin of waste water.H. cation exchange capacity and its determination. Introduction to Solids.Mermin.Den and F. Cambridge University Press-Vikas Publishing House. sulphur oxides.Settle. fluoride.Woolfson. mercury and arsenic. Arnikar Wiley Eastern Ltd.A Skoog. Heavy metal pollution: public health significance of cadmium. potassium and calcium. Methods of safe disposal of radioactive wastes. sulphate. copper. Effects on vegetation and health. silica.. Objectives of analysis.New Delhi(1980) X-ray Structure determination: A Practical Guide. 4. acid soils-types of soil acidity. analysis of major constituents of soilorganic matter.H. manganese. D. 5. Principles of Instrumental Analysis.Azaroff.A.V.W. Holler and T. A survey of reactions and methods involved in the determination of carbon monoxide. Ewing McGraw Hill 2004 C-402 AC ENVIRONMENTAL AND BIOCHEMICAL ANALYSIS 52 Hours I Air Pollution 6h Types and sources of air pollutants. Radioactive Pollution 3h Sources of pollutants. 6. George H Stout and Lyle H Jenson. measurement of pH and conductivity of soil. zinc.Merrit. 2. lead. New York. 58 . industrial and agricultural soil as sources of pollution. 7. 8. H. nitrogen oxides. Principles and methods of sampling.W. Chemical properties of soil-types of soil colloids. An Introduction to X-ray Crystallography. Pesticides as water pollutants and their analysis.M.Willard. N.SUGGESTED BOOKS 1. 1960.A. J. G. IV. nitrogen. chloride. acidity. hydrocarbons and particulates. L. 2004 Instrumental methods of Chemical Analysis. Soil Analysis 5h Physical properties of soils-soil texture and soil structure. total solids. Detection and monitoring of radioactive pollutants. general survey of instrumental techniques for the analysis of heavy metals in aqueous systems. Solid State physics. phosphates and different forms of nitrogen. 3. CBS publishers and distributors. Nieman. Natural background concentrations of air pollutants. alkalinity. F. Parameters of analysis: colour. Types of water pollutants and their effects.saline and alkaline soils. L. sulphur. Thomson 5th Edn. liming. Holt Saunders International Limited. McGraw Hill Book Co. III.Ashcroft and N. M.J.L.Inc and Macmillan Publishers Essentials of Nuclear Chemistry. types of clays and their swelling and adsorption properties. 1986. turbidity.. chromium. Water pollution laws and standards. Consequences of air pollution. Sources of water pollution: domestic.A.New York(1976). diazepam. barbiturates. Immunoassay: ELISA and RIA and their applications. gas chromatography for organophosphates. SUGGESTED BOOKS 1. war gases. aflatoxins in foods. morphine. crude fibre. liquid and gas fuels. VIII.D. 4. carbohydrate. Estimation of rancidity. blood glucose. 2. sodium and phosphate in foods. P. blood urea nitrogen. B. Tests for common adulterants like argemone oil and mineral oils. Stern. estimation of added water. M. cottonseed oil and mustard oil. Estimation of saccharin. fat.sorbitrate. Pesticide analysis in food products. crude protein. Saunders 59 (1980) . castor oil. Drugs of abuse: Analysis of narcotics (nicotine. Gaseous fuels: producer gas and water gas. Environmental Pollution Analysis. Lipid Analysis 6h General composition of edible oils. 3. fermentation test. Vowels and D. phosphatase test for pasteurisation. Characterisation of common drugs: Analgesics-aspirin. Collection and preservation of samples. Tests for groundnut oil. paracetamol. potassium. and copper. cyanide.Cardiovascular. aldolase. carbon residue. Fuel Analysis 3h Solid. dye reduction tests( methylene blue and resazurin ) . ash.W. Sedatives. heating values. methyldopa. screening by gas and thin-layer chromatography and spectrophotometric measurement.alcohol test. Qualitative tests for purity. carbon monoxide and opium. globulins. Vitamins. Clinical analysis: serum electrolytes. General discussion of poisons with special reference to mode of action of snake venom. calcium. 6. Beverages. Clinical Chemistry 7h Composition of blood. APHA (1980) Fundamentals of Analytical Chemistry. Food Analysis 7h Estimation of moisture. chloramphenicol.A and C. and blood gas analysis. tests to distinguish butter and margarine. Estimation of drug residues in biological samples. uric acid.caffeine and chicory in coffee. Liquid fuels: flash point. Khopkar. 5. isoenzymes of lactate dehydrogenase.extraction and purification of sample. Analysis of common adulterants in foods: Milk and milk products. Connel. Holler and Saunders Principles of Instrumental Analysis.A . IX. Katz. Enzyme analysis: Assay of acid and alkaline phosphatases. Metal deficiency and disease. ampicillin. Analysis of Drugs and Poisons 8h Classification of drugs. aniline point. iron. Skoog. D. West. S. thin-layer chromatography for chlorinated pesticides. Estimation of calcium. Skoog and W.Benadryl. coal tar dyes. albumin. carbon monoxide and barbiturates. VI. Expectorants. Wiley Eastern. Antibioticspenicillin. Ultimate and proximate analysis. grading of coal. WHO (1969) Handbook on Air Pollution. VII. octane number and cetane number. heroin) and other dangerous drugs.V.M. Estimation of cyanide. methanol in alcoholic drinks. Experiments in Environmental Chemistry.. calorific values. Pergamon Measurement of Air Pollutants. Preparation of nanoscale materials: Precipitation.ceramic methods .F. Miller.L. solid solution and compound precursors (nitrates . Underwood. selfassembly: chemical vapour depostition. 10. A New Materials 8h Fullerenes and fullerides – structure. K.H. PPP.carbonates. C. Combs and H. Tata McGraw Hill (1976) Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. S.Cobalt.Macy. R. applications. Gold. Woodman. Rapher.7. Quantitative Analysis. 20. (1967) Chemistry: Principles and Applications. H. nano wires and nanotubes.A. Prentice Hall Food Analysis.Sr and Ba cuprates. ( 1976 ) Methods of Soil Analysis Part I & II. G. Principles of self-assembly: surfactant solutions. perovskite A & B.PA. A. C 403 . Black et al (Ed) American Society of Agronomy. 18. Arnold Heinmann Lynch's medical Laboratory Technology.I. Wiley Eastern. functionalisation approaches conducting properties of fullerides. PPY – mechanism of conduction and applications II B Nanomaterials 12h Classification types of carbon nano tubes synthesis. spray pyrolysis. evaporation. (1987) Milk and Milk Products. statistical mechanics of one-dimensional self-assembly. Narayan Reddy [Suguna Devi. Roy Keller. Day and A. Hesse.structure. hydrothermal. Ed. Elemental nanoparticles: Pure. 11. synthesis. functionalization charecterization and applications. structure and synthesis of La. Dekker Inc. Wadsworth Publishing Co.A. Inc. 21. (1994). Shadaksharaswamy and Manay. W. Dorge The Essentials of Forensic medicine and Toxicology. Oxide nanoparticles: Silica. 9.CHEMISTRY OF MATERIALS (ELECTIVE) (Common to Inorganic and Analytical Chemistry) 52 hours I Preparative techniques 8h Principles of solid state synthesis . 14. Wilson and Goulding ( 1981 ) Analytical Biochemistry. 13. electrosynthetic II. characterization and applications of nanoparticles. Alumina. M. (1965) A text book of Soil Chemical Analysis – P. R. sputtering.S. Tata McGraw Hill (1976) Practical Clinical Biochemistry. 16. Conducting polymers . McGraw Hill (1971) Foods: Facts and Principles. 8. Synthesis. co-operativity. B. PPS. mechanical milling. Zinc oxide. sol-gel. Holmes and Peck.R. combustion. 60 . NASICON and alumina – structure and conducting properties. Longmans (1983) Separation Techniques in Chemistry and biochemistry. Eckles. hydroxides . 17.B. importance of non-covalent forces. Oser. Iron oxide. High-Tc Oxides . 12. Ed. Varley. 15. CBS Publishers.cyanides and organometallics). the hydrophobic effect. Itaku-Shoin / Saunders (1983) A Biologist's Guide to Principles and Techniques of Practical Biochemistry. colloidal routes.S. Silicon. 19. C. Silver . Hyderabad] (2002) Hawk's Physiological Chemistry. glass formation. V Amorphous Materials 6h Crystalline versus amorphous solids. . London 2005. C.meltspinning. Structural models of amorphous materials. Nitro. 3.thermotropic and lyotropic liquid crystals Calamitic. nematic phase. smectic phase. John Wiley & Sons. New York. (1991) Solid State Chemistry and its applications . (1985).(1989). properties and applications. RSC. metal-matrix. C-404 SPECTROSCOPY – III 52 h (Common to Inorganic . John Wiley and Sons Inc. ion implantation. plastic-matrix composites.Koch. Microporous materials – zeolites and zeolitic materials.mechanical. TaS2.R. A. sulphato and other acido complexes. IV Fibres and Composites 8h Synthetic inorganic polymers. By C. ethylenediamine and diketonato complexes 61 . sputtering. chiral nematic phase and optical Properties of liquid crystals SUGGESTED BOOKS 1. AB5 and AB6 molecules. Srivastava and C. Properties of metglasses . amido. lattice water. mono and multinuclear carbonyl complexes.III Intercalation compounds 6h Intercalation reactions . ed. Callister . Nanotubes and Nano wires CNR Rao.GaPO4. West. Willaim Andrew Publishing. Cammarata. AB3. ambidentate ligands. phosphines and arsines. Science of Engineering Materials. UK 1966. microscopic composites. staging of graphite. Nanomaterials: Synthesis. dispersion strengthned. 2. 4 5 6 7.S. By A. spectra of metal complexes: Ammine. Properites and Applications.zirconia and other fibre Classification. Srinivasan.Physical Chemistry and Analytical) I Vibrational spectroscopy 9h Vibrational spectra of diatomic. nitrato. cyano and nitrile complexes.Edelstein and R.layered structure-graphite interlayer compounds(GILC). Nitrito.Fibre-glass reinforced composites. Prepararion techniques. W. Inst. linear and bent triatomic. electronic and magnetic properties. 2002. Material Science and Engineering. carbonato. Encyclopedia of Nanomaterials and Nanoteachnology Hari Singh Nalva Nanostructured Materials: Processing.D. AB4. of Physics. nitrosyls. aquo and hydroxo. Wiley-Eastern Ltd. particle reinforced. & A Govindaraj.C.M. classification . Ed. VI Liquid crystals 4h Mesomorphic behaviour. hybrid composites.C. mesophase. cyanato and thiocyanato complexes. AlPO4. Valence level spectra. Sn2+ and Sn4+ compounds VIII NQR spectroscopy 4h NQR isotopes. electronelectron coupling. double resonance in ESR. application to transition metal complexes (having one to five unpaired electrons) including biological molecules and inorganic free radicals such as PH4. σ and π bands. application to the study of bonding and structures of Fe2+ and Fe3+ compounds. Spin polarization for atoms and transition metal ions. determination of ‘g’factor. Koopman’s theorem. Electron energy loss spectroscopy. Lasers and their use in Raman spectroscopy III Photoacoustic spectroscopy Basic description and applications 2h IV Photoelectron spectroscopy 8h Basic principles. ENDOR. applications of core level spectra-ESCA. isomer shift. Experimental techniques and applications XI X-ray absorption spectroscopy Near edge measurements and EXAFS 2h 62 . VII Mossbauer spectroscopy 5h Basic principles. Nonlinear Raman effects-Stimulated. quadrupole splitting and magnetic hyperfine interactions. significance of ‘g’ factor. XPS and UPS. Kramer’s degeneracy. zero/non-zero field splitting. Solid State NMR. 31P. Spin density and Mc Connell relationship.basic principles and applications Applications to the study of solids V NMR spectroscopy of inorganic molecules 8h Proton NMR spectra of metal hydride complexes NMR spectra of nuclei other than hydrogen: 19F. ESR spectrometer. 183W.n. Electron-nucleus coupling (Hyperfine splitting). VI Electron spin resonance spectroscopy 10h Basic principles.photoelectric effect. the position of ESR absorption. chemical shift. spin-orbit coupling and significance of g-tensors. Auger electron spectroscopy and applications. electric field gradients.II Raman spectroscopy 4h Resonance Raman Spectroscopy. hyper and inverse types. spin-orbit coupling in core level spectra. F2 and BH3. 11B NMR spectra of simple compounds. Nuclear Quadrupole coupling constants. 195Pt and 207Pb in metal complexes/organometallic compounds. Interpretation of ESR spectra and structure elucidation of organic radicals using ESR spectroscopy. Proton/hydride interactions with 103Rh. ELDOR. D. Synthesis of spinels/pervoskites and their characterization by XRD studies 14. Estimation of copper by electrogravimetric method 25. AAS Estimation of Cu. 4. Physical methods in Inorganic Chemistry. Analysis of calcium and magnesium in milk 11. New Delhi (1965). Electronic Absorption Spectroscopy and Related Techniques.405 Analytical Chemistry Practicals – III 1. Affiliated East West Press Pvt.N. K. Bangalore (2001). Wiley-Interscience. Synthesis of zeolites and measurement of surface acidity 13. Differential potentiometric titration of acetic acid vs. Na 10. Vibrational Spectroscopy: Theory and Applications. 3. Ltd. Estimation of sulphate as benzidine sulphate 4. Separation of metal ions by paper chromatography/TLC 6. Spectrophotometric determination of uranyl ion by solvent extraction 24. Sathyanarayana.. Estimation of copper using salicylaldoxime 3. Polarographic analysis-identification and estimation of metal ions 26. Drago. Spectrophotometric determination of metal-ligand ratio in Iron-iron complex using Jobs method 22. Cyclic voltammetric behaviour of a metal complex 63 . 2. Infrared spectra of Inorganic and Coordination Compounds. C. Conductometric titration of HCl vs. Separation of zinc and cadmium by ion exchange chromatography 7. Universities Press. Flame photometric estimation of K. D. Estimation of metal acetates using perchloric acid in glacial acetic acid medium 5. Fe.S. New York (1970). Sathyanarayana. Flame spectrophotometric estimation of potassium sodium and potassium 21. Complexometric titration of copper/nickel using DMG by potentiometry 19. sodium hydroxide 15. R.N. Preparation and characterization of a metal complex by IR spectroscopy 12. Estimation of nitrite using chloramines T 2. New Delhi (2000). NaOH in methanol medium 20. New Age International Publishers. Spectrophotometric determination of pK1 value of an indicator 23. Determination of stability constant of copper-ethylenediamine complex by potentiometry 18.SUGGESTED BOOKS 1. Amperometric titration-estimation of lead using potassium dichromate 27. Determination of pka of amino acids by potentiometric titrations 16. Mg and Ca 9. Determination of dissociation constant of phosphoric acid by potentiometric titration 17. Nakamoto. Estimation of Iron III by solvent Extraction 8. (1965). MS 18. Separation of proteins by gel electrophoresis 7. Vogel’s Practical Organic Chemistry. C. 6. David Plummer. Estimation of fat in milk 9. Extraction of caffeine from tea leaves. Goel Pub. Estimation of rancidity in a sample of butter 10. Practical Clinical Biochemistry . 3. NeYork. C. characterization by IR.Hannaford.Connel. P. Estimation of morphine in a drug sample 13. Estimation of protein in food samples 23. 4. 4. Estimation of Vitamin A in food samples 24.Tata McGraw Hill(1979) Laboratory Manual in Biochemistry. H.IV 1. Ed. 2. Isaac Pitman(1964) Polarographic methods of analysis by Meites.406 Analytical Chemistry Practicals . G. Separation of amino acids by thin layer chromatography 5.I.(1981) Methods of Soil analysis Part I & II. Estimation of Cholesterol in serum 20. C . 6. Estimation of glucose in serum 19. Vogel. Estimation of nucleic acids 22.J. Nitro and Methoxy groups 2.Vowels and D. Experiments in Environmental chemistry. L.A. Text book of Quantitative Inorganic Analysis by A. ELBS London (1978). Estimation of alkaline phosphatase SUGGESTED BOOKS 1. Inc.ELBS(1978) Advanced Physicochemical Experiments by Rose.(1955) Findlay’s Practical Physical Chemistry by Levitt.W. Estimation of BOD and COD of a water sample 15. Longmann’s(1966) Experimental Physical chemistry by J B Yadav.Varley and Anold Heinmann(1978) An introduction to practical Biochemistry. J. Separation of fatty acids using gas chromatography 8. Inc. Jayaraman. separation of alcohols by gas chromatography 6. Pergamon(1980).Wiley Eastern(1981) Chromatography. Estimation of a common drug(paraacetamol) 14.SUGGESTED BOOKS 1. Estimation of nicotine in tobacco 12. Separation of lipids by thin layer Chromatography 4. Estimation of lead in water samples 16.A. 3. Estimation of sulphur oxide and nitrogen oxides in air samples 11. Determination of carbon residue in petrol 25. Intersciences Publishers. Estimation of blood urea nitrogen 21. Sharma 64 . Estimation of Nitrogen. Black et al(Ed) American Society of Agronomy. Estimation of pesticide in soil samples 17. Assay of alanine and aspartate aminotransferases 26. 5. Separation of essential oils by column chromatography 3. NMR. 2. House. 5.D. classification. classification of ligands. II. bonding. Organometallic compounds in organic synthesis. butadiene. structure. Green rules. Cluster valence electron count. cyclobutadiene. CO. cyclohexa and cycloheptadienyl moieties. uses of iron and chromium carbonyls in the synthesis of aromatic compounds. IV. 4h VII. 6h Introduction to M-M bonds and metal atom carbonyl clusters LNCC’S HNC’S. Fluxional behavior in organometallic compounds. Organometallic compounds of main group elements. Photochemical reactions of organotransition metal complexes. olefins. allyl moieties. 9h General introduction . Photochemical reactions with cleavage of Metal-Metal bonds. VI. carbenes and carbynes п-bonded systems involving dihapto to octohapto ligands like acetylene.electron rules. 5h Introduction. cyclohepta and cyclooctatrienes. Rates of rearrangement and techniques of study. 6h III. η3-allyl and dienyl complexes. Gilman reagent (lithium dialkyl cuprate). Group trends-Synthesis. cyclooctatetraene moieties and ring slippage reactions. Be. 3h Introduction. arenes. photochemical substitution at metal carbonyls. isocyanides. Synthesis. Wade-Mingos-Lauher rules. CO2.and 18. structure and bonding in Li. 65 . Isoelectronic and isolobal concepts . V. Metal-hydrogen bonds and metal-carbon bonds.FOURTH SEMESTER INORGANIOC CHEMISTRY SPECIALISATION C.401 IC ORGANOMETALLIC CHEMISTRY 52 Hours I. VIII. η2-olefin. organoaluminium and organomercurials in organic synthesis. CF and alkane activation (cyclometallation reaction). Electron counting-covalent and ionic models. Mg and Al alkyls. use of zinc dialkyls. cyclopentadiene. Organometallic complexes. Fluxionality and dynamic equilibria in compounds such as CO. 4h Stability and decomposition paths. reactivity and decomplexation reactions of organotransition metal complexes having σ-and п-M-C bonds. Nomenclature of Organometallic complexes. 12h σ-Bonded systems involving carbonyls. Grignard reagent. Structure and bonding in carbonyl clusters-the isoelectronic and isolobal analogy. lithium alkyls. Heck reaction . 16. Activation of small molecules. polymer and metal oxides as supports. ch. R. oxford. SUGGESTED BOOKS 1. OxfordUniversity Press. New age international. 1992. M.Collman. oxidation-addition and reduction elimination.R.H. advantages. hydrocyanation-Nylon intermediates: buta-1. Oxford Chemistry primers. alcohol dehydration on ν-alumina. asymmetric hydrogenation . Davies. 4.3-diene hydrocynation. Ammonia synthesis. J. Organometallics.merits. 2000. physisorption and chemisorption. surface area and pore structure of catalysts and their determination.G. Zeigler-Natta polymerization –syndiotactic and Isotactic polymersLiving polymerization.C. acid-base catalysis. classification of catalysis systems. Nucleophilic and electrophilic attack of coordinated ligands. L. 1986. J. Olefin metathesis. Macmillan. hydrogenation hydroformylation involving cobalt and rhodium catalysts (oxo process). An introduction to organometallic chemistry A. Reactions of organometallic complexes 3h Substitution reaction in carbonyl complexes. reactions of olefins on zinc oxide. Catalytic converters 9h Anchored catalysis. 2nd edition 1992. Pargamon Press. R. Oxford Chemistry primers.Singh.C. 10 h Fischer-Tropsch process. 2nd edition. Organometallic reagents in synthesis. The organometallic chemistry of transition metals.gas shift reaction. Reppe Monsanto process-acetic acid from methanol.R. Organotransition metal chemistry. clays as catalysts. II. S.IX. hydrosilation. transferhydrogenation. alkene isomerisation.University Science book.P. John Wiley 3rd edition 2001. 3. Wacker process-acetaldehyde from ethylene. 2.Acetic anhydride from methyl acetate. Introduction 4h Basic principles. thermodynamic and kinetic aspects. displacement reactions.catalyst preparation. Homogeneous catalysis 19 h Principle. oligomerisation -Shell high olefin process. Vol. metal complexes and organometallic complexes.W.Norton. Zeolites-shape selectivity. 1982. phase transfer catalysis. III. Parkins and R.S. Crabtee. 66 .G. Organometallic chemistry. VCH. Heterogeneous catalysis 10 h General aspects. 6. and R. insertion and elimination reactions. P. experimental techniques. Decomposition of iso-propanol using oxide catalysts. Tennessee Eastman process.Slazer. Jenkins. gas-solid interface. Experimental methods and laboratory reactors. Poller. 1987. 1994. 8.acrylic ester from acetylene: ethylene glycol from synthesis gas. Principles and application of organotransition metal chemistry. water.Mehrotra and A.hydrogenation. 7. Acrylonitrile synthesis using mixed metaloxides. Elschewbroich and A. Pillared clays. 5. 1 and 2.advantages. Reppe carbonylation. Carbonylate anions as nucleophiles. industrial requirements. catalysis involving transition metal salts. Organometallic chemistry. Finke . Bochmann.Hegdus. Adsorption isotherms-Langmuir and BET isotherms. C-402 IC HOMOGENEOUS AND HETEROGENEOUS CATALYSIS 52 Hours 1. photochemical stages. J. zerozero spectroscopic energy. electronically excited states of metal complexes.Hegedus. Chakarborty & B.quenching III Excited states of metal complexes 8h Excited states of metal complexes: comparison with organic compounds.R. Homogeneous catalysis by metal coplexes. excitation. 6.A. 2000. Catalytic Chemistry. 1. Oxford University primers. metal complexes as attractive candidates (2. methods of obtaining charge transfer spectra IV Ligand field photochemistry 8h Photosubstitution. Bimolecular deactivation. dipole moment. absorption spectra. Principles and practice of heterogeneous catalysis. R.Crabtee. 7.Chakarborty. Photochemical kineticscalculation of rates of radiative processes. Wiley –Eastern Ltd.K. 2nd edition. R. electronically excited states-life time measurements. VCH (1996). M.Anderson and M.Martell.Thamas. University Science Book (1980). SUGGESTED BOOKS Organometallic Chemistry.Colman and L. Principles and applications of organo-transition metal chemistry.Biological catalysts. charge transfer spectra.carbonic anhydrase.Singh.J. JohnWiley & sons (1992). New Age international (P) Ltd. stopped flow techniques.Boudart.H. Flash photolysis.P.exciplex formation.Mehrotra and A.Thamas and W. photooxidation and photoreduction..2’-bipyridine and 1. conditions for the excited states to be useful as redox reactants. quantum yield.C. organic catalysis –Ribonuclease and lysozyme. 3. photochemical laws.M. metalloenzymes.. B. Adsorption and catalysis by solids. Springer-Verlag (1984). D. Applied organometallic Chemistry and Catalysis Robin Whyman. 5. 1998. lability and selectivity.Viswanathan.Gates. J. development of the equations for redox potentials of the excited states V Redox reactions by excited metal complexes 13 h Energy transfer under conditions of weak interaction and strong interaction. energy content of the excited state. 2. 2000. The organometallic Chemistry of the transition elements. (2001). excited electron transfer. zero vibrational levels of ground state and excited state. John Wiley & Sons. J.Michaelis-Menten kinetics. 10.C.primary and secondary processes II Properties of excited states 9h Structure.10-phenanthroline 67 .S. free radical reaction catalysed by vitamin B12. (1991). Catalysis-Science and Technology. Academic press (1974). Heterogeneous catalysis D.K. New Age international (P) Ltd. 4. C-403 IC PHOTOINORGANIC CHEMISTRY (ELECTIVE) (Common to Inorganic and Analytical Chemistry) 52 Hours I Basics of photochemistry 9h Absorption. 9. Franck-Condon principle. acid-base strengths and reactivity. charge transfer excitations. 8. Energy dissipation by radiative and non-radiative processes.Taqui Khan and E.M. W. G. Photochemistry of Coordination Compounds. 10). electron relay. chemical energy into light VI Metal complex sensitizers 5h Metal complex sensitizers. J. sol-gel. illustration of reducing and oxidizing character of Ru2+ bipyridal complex. metal colloid systems. selfassembly: chemical vapour depostition. 131.ceramic methods . 39 (1981) 121. semiconductor supported metal or oxide systems. 30. nitrogen fixation and carbon dioxide reduction SUGGESTED BOOKS 1. High-Tc Oxides .complexes). PPP. hydrothermal. Concepts of Inorganic Photochemistry. Carassiti. 5. comparison with Fe(bipy)3. 68 .CHEMISTRY OF MATERIALS (ELECTIVE) (Common to Inorganic and Analytical Chemistry) 52 h I Preparative techniques 8h Principles of solid state synthesis . 1983. statistical mechanics of one-dimensional self-assembly. solid solution and compound precursors (nitrates . S. Preparation of nanoscale materials: Precipitation. Chem.J. Vol. PPY – mechanism of conduction and applications II B Nanomaterials 12h Classification types of carbon nano tubes synthesis. Inorganic Photochemistry. Conducting polymers . hydroxides . PPS. V. Application of redox processes of electronically excited states for catalytic purposes. 4.J. applications. spray pyrolysis. Ed. perovskite A & B. 2. co-operativity. functionalisation approaches conducting properties of fullerides. Wiley. Elements of Inorganic Photochemistry. Lippard. synthesis. 6. Coordination Chemistry Reviews. Balzari and V.PA. colloidal routes. 97 (1990) 313. evaporation. role of spin-orbit coupling.cyanides and organometallics).Sr and Ba cuprates. A.. A New Materials 8h Fullerenes and fullerides – structure. mechanical milling.carbonates. transformation of low energy reactants into high energy products. Progress in Inorganic Chemistry. functionalization charecterization and applications. electrosynthetic II. 15 (1975) 321. Academic Press.life time of these complexes. Wiley. structure and synthesis of La. combustion. NASICON and alumina – structure and conducting properties.D.structure. 60 (No.. Fleischauer. Ferraudi. C -403. Ed. importance of non-covalent forces. Principles of self-assembly: surfactant solutions. 3. sputtering. water photolysis. the hydrophobic effect. Adamson and P. Ed.S.Synthesis. By A. Microporous materials – zeolites and zeolitic materials. Alumina.zirconia and other fibre Classification. amido. RSC. By C. nematic phase.meltspinning. Properties of metglasses . Srinivasan. characterization and applications of nanoparticles. VI Liquid crystals 4h Mesomorphic behaviour. 69 . 2. smectic phase. Oxide nanoparticles: Silica. carbonato. Encyclopedia of Nanomaterials and Nanoteachnology Hari Singh Nalva Nanostructured Materials: Processing. linear and bent triatomic. IV Fibres and Composites 8h Synthetic inorganic polymers. Elemental nanoparticles: Pure. & A Govindaraj. Willaim Andrew Publishing. Nanomaterials: Synthesis. classification . microscopic composites. glass formation. sputtering. V Amorphous Materials 6h Crystalline versus amorphous solids. mono and multinuclear carbonyl complexes. Wiley-Eastern Ltd. spectra of metal complexes: Ammine. dispersion strengthned. plastic-matrix composites. III Intercalation compounds 6h Intercalation reactions .M.mechanical. Nitrito. AlPO4. Silicon. . 2002.C. Cammarata. Material Science and Engineering.C. ion implantation. C404 SPECTROSCOPY – III (Common to Inorganic and Physical Chemistry) 52Hours I Vibrational spectroscopy 9h Vibrational spectra of diatomic. UK 1966.Koch. AB5 and AB6 molecules. C. cyano and nitrile complexes. 4 5 6 7. Science of Engineering Materials.layered structure-graphite interlayer compounds(GILC).D. TaS2. properties and applications. particle reinforced.R. Gold. Prepararion techniques. AB3. of Physics. chiral nematic phase and optical Properties of liquid crystals SUGGESTED BOOKS 1. New York. mesophase. John Wiley & Sons. AB4. lattice water. Zinc oxide. cyanato and thiocyanato complexes. ed. London 2005. Nanotubes and Nano wires CNR Rao. A. Structural models of amorphous materials. electronic and magnetic properties.(1989).GaPO4. staging of graphite. nano wires and nanotubes. nitrato. (1991) Solid State Chemistry and its applications . Nitro.Fibre-glass reinforced composites. hybrid composites.Cobalt. Iron oxide. sulphato and other acido complexes. Properites and Applications. metal-matrix. 3. Silver .Edelstein and R. W. Inst. West. John Wiley and Sons Inc. Srivastava and C. (1985). aquo and hydroxo.thermotropic and lyotropic liquid crystals Calamitic. Callister . Spin polarization for atoms and transition metal ions. Nonlinear Raman effects-Stimulated. ESR spectrometer.nitrosyls. VI Electron spin resonance spectroscopy 10h Basic principles. Experimental techniques and applications 70 . 183W. Interpretation of ESR spectra and structure elucidation of organic radicals using ESR spectroscopy. VII Mossbauer spectroscopy 5h Basic principles. 31P. Auger electron spectroscopy and applications. application to the study of bonding and structures of Fe2+ and Fe3+ compounds. isomer shift. Kramer’s degeneracy.n. Lasers and their use in Raman spectroscopy III Photoacoustic spectroscopy Basic description and applications 2h IV Photoelectron spectroscopy 8h Basic principles. Electron energy loss spectroscopy. Spin density and Mc Connell relationship. ELDOR. σ and π bands. phosphines and arsines. electric field gradients. Nuclear Quadrupole coupling constants. double resonance in ESR. F2 and BH3. the position of ESR absorption. applications of core level spectra-ESCA. chemical shift. Koopman’s theorem. hyper and inverse types. 11B NMR spectra of simple compounds. application to transition metal complexes (having one to five unpaired electrons) including biological molecules and inorganic free radicals such as PH4. Sn2+ and Sn4+ compounds VIII NQR spectroscopy 4h NQR isotopes. ethylenediamine and diketonato complexes II Raman spectroscopy 4h Resonance Raman Spectroscopy. ambidentate ligands. determination of ‘g’factor. spin-orbit coupling and significance of g-tensors. quadrupole splitting and magnetic hyperfine interactions. Valence level spectra. significance of ‘g’ factor. spin-orbit coupling in core level spectra. XPS and UPS. zero/non-zero field splitting. Solid State NMR. Proton/hydride interactions with 103Rh.basic principles and applications Applications to the study of solids V NMR spectroscopy of inorganic molecules 8h Proton NMR spectra of metal hydride complexes NMR spectra of nuclei other than hydrogen: 19F. Electron-nucleus coupling (Hyperfine splitting). electronelectron coupling. ENDOR. 195Pt and 207Pb in metal complexes/organometallic compounds.photoelectric effect. 2h Physical methods in Inorganic Chemistry.S. New Delhi (2000). Ni2+ and Cu2+ ions Preparation and analysis of cis and trans. D. 2. 3. 4. Sathyanarayana. Preparation and analysis of Potassium ris(oxalato)ferrate(III)trihydrate Preparation of Potassium tris(oxalato)aluminate(III)trihydrate Preparation and analysis of Hexamminecobalt(III) chloride Preparation of Pentamminechlorocobalt(III) chloride Preparation and magnetic susceptibility studies of Mercury cobalt(II)thiocyanate Magnetic susceptibility studies of copper sulphate pentahydrate and ammonium ferrous sulphate Preparation and analysis of lead tetraacetate (non-aqueous reaction) Preparation and IR spectral studies of Pentamminenitrocobalt(III) chloride and the corresponding nitrito complex Redox chemistry of WO3 Paper chromatographic separation of Co2+. 15. 9. 8. New Delhi (1965). 11. 3. 3. Sathyanarayana.potassium dioxalatodiaquochromium (III) complex C406 INORGANIC CHEMISTRY PRACTICALS-IV 1. (Instrumental Techniques) Preparation and spectrophotometric analysis of Hexamminenickel(II) chloride. Wiley-Interscience. 5. (4 days a week 4 ½ hours a day) Determination of the percentage purity of nitrite Estimation of sulphate by the EDTA method Estimation of sulphate using benzidinehydrochloride Microvolumetric estimation of chloride. 13. 7. New York (1970). 16.N. New Age International Publishers. C405 INORGANIC CHEMISTRY PRACTICALS. Universities Press. Infrared spectra of Inorganic and Coordination Compounds. Electronic Absorption Spectroscopy and Related Techniques. Ltd.N. 2.. 6. Drago. Affiliated East West Press Pvt. Bangalore (2001). Nakamoto.III 1.XI X-ray absorption spectroscopy Near edge measurements and EXAFS SUGGESTED BOOKS 1. Analysis of Wood’s alloy. K. 10. 12. Vibrational Spectroscopy: Theory and Applications. 14. D. Synthesis and spectral study of copper(II) complexes Synthesis and electrogravimatric analysis of Copper(II) aspirinate 71 . 4. 2. R. Al. Organometallics as electrophiles and nucleophiles: Nucleophilic addition to h2.Himalaya Pub House(2003). Complexation and De-complexation Reactions: s-Bonded systems including h1 ligands. Nickel. 2. 3. FOURTH SEMESTER ORGANIC CHEMISTRY SPECIALISATION C-401 OC ORGANOMETALLIC AND HETEROCYCLIC CHEMISTRY 52 Hours I. allyl moieties. h6 and carbene complexes. A.olefins. Academic Press (1967). Academic Press(1963). 11. Suib. Visible absorption spectrum of KMnO4. Rockett. Vogel. Electrophilic addition to h4. G. 14. cyclobutadiene. 5. Huber. 7. K. Practical inorganic chemistry. W. G. butadiene. Cambridge University Press (1954). 3h 72 . ELBS (1962). cyclopenta. 12.D. Experimental inorganic chemistry. K2Cr2O7 and other complexes prepared in C205 Determination of the conductivity of 1:3. h5 and h6 complexes. cyclohepta. Interpretation of IR. and cyclooctatetraene moieties. London (1972). 9. Plamer. 18. Non-aqueous titrations. Organometallic Compounds In Organic Synthesis Chemistry of Organotransition metal complexes: General introduction. 1:2 and 1:1 complexes Electrogravimetric analysis of Copper.. T. I. acetylenes. arenes.V. Li and Ca. UV-visible and HINMR spectra of selected complexes. acetylenes and dienes. 4. Marr and B. L. Fe (orthophenanthroline method).4 5. 8. Non aqueous titrations. Experiments in Chemistry . A text book of quantitative analysis. W. pBonded systems involving dihapto to octahapto ligands such as. 6. 10. Experimental Methods in inorganic chemistry.Cobalt and Lead. Determination of Copper and Cobalt Spectrophotometrically. 6. Determination of the stability constant of silverammine complex by potentiometry Determination of the stability constant of the ferricsalicylate complex spectrophotometrically Equilibrium constant of the Monothiocyanatoiron(II) ion Colorimetric estimation of Ni. Vols I and II. 13.Jahagirdar. 7. General rules. Ti and Mn in steel. Hand book of preparative inorganic chemistry. SUGGESTED BOOKS 1. Stabilization of cyclobutadines and norbornadienones. Von Nostrand Reinhold Co. Brauer. Tanaka and S.and 16-Electron rules. Prentice Hall (1999). G. cyclooctatrienes. cyclohexa and cycloheptadienyl moieties. Flame photometric determination of Na. 5h Use of organotransition metal complexes as protecting and stabilizing groups: Protection of olefins. deoxygenation of epoxides. reaction with C-C multiple bonds. oxidation and reduction reactions: Isomerization of olefins. Solvomercuration-demercuration and cyclopropanation of alkenes. Simmons Smith.McCombie reaction. Organocopper reagents: (Gilman reagents-lithium dialkyl cuprates): Preparation. reaction with compounds containing acidic protons. hydroalumination and carboalumination of alkenes. and coupling of olefins with acetylenes (including Felkin’s reaction). 2h Organometallics in isomerization. benzyl and aryl halides. Organoaluminiums: Preparation. lactones from allylic alcohols and in the hydroformylation of olefins. Organolithiums: Preparation. ketones (including a. nucleophilic addition reactions. and vinyl epoxides. vinyl. dienes and allenes. aldehydes. aldehydes or acyl halides from alkyl halides and in the hydroformylation of olefins and dienes. trans-metallation. Preparation of alkenyldialkylalanes and their reactions. Oxidation of olefins (including Wacker’s process and epoxidation) and reduction of olefins and α. preparation and general reactions of trialkylsilyl halides. 4h Application of the following organometallics in Organic Synthesis: Organozincs: Preparation. Use of cobalt complexes in the synthesis of ketones from epoxides. reactions with imines. oxidation of hydroquinone and synthesis of biaryls. 4h Organoseleniums: preparation. Organotelluriums: Debromination of vic-dibromides. Peterson olefination. 5h 73 . nitriles and isonitriles. Use of iron complexes for the insertion of CO group into organic molecules such as dienes. alkyl halides.b-unsaturated carbonyl compounds) and epoxides. Use of organoseleniums in the synthesis of alkenes fromalkyl halides.β -unsaturated carbonyl compounds from carbonyl compounds. Use of palladium complexes for the carbonylation of alkyl halides. Organotins: Preparation and reactions of tri-n-butyltin hydride. Deprotonation reactions. and Reformatsky reaction. acids. α. allylic alcohols and allylic ethers. 4h Organosilicons: Introduction. Barton decarboxylation and Barton. Nucleophillic addition reactions with carbonyl compounds and Hydrocyanation.Organometallics in coupling and cyclization reactions: Coupling and cyclization of organic nucleophiles with olefins (including Heck reaction).β-unsaturated compounds (including Wilkinson’s reaction). allyl. Organomercurials: Preparation. 3h Carbonylation reactions: Use of zirconium complexes in the synthesis of esters. Electrophilic substitution reactions. reactions with alkyl. addition reactions of zinc reagents with carbonyl compounds. Organocerates: Preparation and reactions of organocerates. 12. Vols. Singh. Mehrotra and A. diazocines. 3h 6h 74 . The Chemistry of Heterocycles. benzoxazoles. Wiley Eastern. G.membered heterocycles with P. Springe rVerlag. 1986. 2. 1991. An introduction to Heterocyclic Compounds. M. Davies. R. House. R. benzothiophenes. 2h Seven and large membered heterocycles: Synthesis and reactions of azepanes. Rotaxanes: Preparation of any two important rotaxanes and their applications. Wiley-Inter Science. P. Newkome. 15. 2008. Oxford University Press. 7. Poller. C. SUGGESTED BOOKS 1. J. 1988. Heterocyclic Chemistry. Heterocyclic Chemistry. Oxford. A.and 6.A. diazepines. thiranes. M. W. Rees. and W. March. D Nasipuri. As. Contemporary Heterocyclic Chemistry. Sb and B: Synthesis of 5. 13. Chapman and Hill. 16. C. Longman Scientific Tech. Bochmann. A. L. Hegedus.and [8]-calixarenes and their application. John Wiley. University Science books. azetidines. Pergamon Press. S. Gupta. 1-3.II. 11. Macmillan. Eicher and S Hauptimann. R. triazines. Eds. Calixarenes: Preparation of [4[-. oxepines. Stereochemistry of Organic Compounds. W. Benjamin. 1980. [6]. Organometallic Chemistry. 1 & 2. Kumar and V. A. 5. 1972. 3. thiazepines. Mills and G.and 4. Collman. H. L. F. azocines. Joule. 1982. T. R. J. Parkins and R. R. aziridines. 2nd Edn. 4. Principles and application of the organotrnsition metal chemistry. Crabtree. 8. New-Age International. 14. 10. Pergamon Press. 9. chemistry of some important meso-ionic heterocycles of type-A and type-B and their applications. (1999). Modern Synthetic Reactions. 1994. H. Comprehensive Heterocyclic Chemistry. Heterocyclic Chemistry. Heterocyclic Chemistry Small ring heterocycles: Properties and reactions of 3. Vol. Organometallics. The Organometallic Chemistry of the transition metals.membered heterocycles:oxiranes. benzothiazoles and benzimidazoles. Gilchrist. 6h Heterocycles containing P. O. 4th Edn. Oxford Chemistry primers. 6. As. thiepines. J. Gupta. Benzo-fused heterocycles: Synthesis and reactions of benzofurans. Mesoionic compounds: General classification. Katritzky and C. Paudler. R. Sb and B. R. T. Acheson. An introduction to Organometallic Chemistry. tetrazines and thiazines. M. dioxocines and dithiocines. oxetanes and thietanes. G. S. 2h 3h Six-membered heterocycles with two or more heteroatoms: Synthesis of Diazines. K. Organotransition metal chemistry. California. Thieme. Advanced Organic Chemistry. Smith. W. Cryptands: Preparation of [2]-cryptands and spherocrptands and their applications. W. John Wiley. Basic principles and terminologies used in disconnection approach. II. Chemoselectivity. III. Determination of R. Trasnannular reactions: Hydrolysis of medium ring epoxides and bromination of C8–C10 cyclic dienes. S.configuration to these classes of compounds. arsenic and sulphur atoms. Rule of optical superposition. adamentanes. Chemical correlation of configuration: Methods without involving the chiral centre. and synthetic equivalents. phosphorous. Use optical rotatory dispersion curves: α-axial haloketone rule and its applications. cyclophanes. Disconnection approach 6h Introduction to synthons.C-402 OC STEREOCHEMISTRY AND RETROSYNTHETIC ANALYSIS 52Hours STEREOCHEMISTRY I. Method based on anomalous X.ray scattering. decalones and cholestanones). iv). Optical activity due to the presence hetero atoms 4h Chirality of organic compounds due to the presence of silicon. Assignment of R. cyclisation reactions. amines. One group C-X and two group C-X disconnections. rotaxanes and helicenes. catenanes. II. Determining absolute and relative configuration 10h i). Chemical correlation involving diastereomers. v). nitrogen. reversal of polarity. ansa compounds. ii). Optical activity in the absence of chiral atoms 5h Chirality in biphenyls. Method based on molecular rotation difference iii) The method of quasi-racemate. trans-cyclooctene. Methods based on comparison of optical rotation: Distance rule. Transannular reactions 3h Conformational analysis of medium rings. Protecting groups Principle of protection of alcohols. octant rule (application of these rules in the determination of absolute configuration of substituted cyclohexanones. acids and carbonyl groups 3h 75 . Chemical transformation involving the chiral centre. Mill’s rule. disconnection approach. RETROSYNTHETIC ANALYSIS I. IV.S-configuration of these compounds using CIP rules. Rule of shift. Use of acetylides and aliphatic nitro compounds in organic syntesis. Stereochemistry. aphidicolin and fredericamycin-A and Lycorane. Coxon. IV. Penzillin. Wilen and L. 1998. John Wiley & Sons. C-C one group and C-C two group disconnections 8h Synthesis of alcohols. New York. MIR. Longman. New Age International Publishers. cortisone. Caruthers. 1999. Eliel. 5. methods and starting materials. Organic synthesis. S. J. 2nd Edn. 1. Diels-Alder reaction. Principles of organic synthesis. 1992. Nasipuri.and 6-membered rings. J. Warren. 1995. Asymmetric Synthesis ‘ee’ and methods of determination of ‘ee’. Synthesis of some complex molecules 10h Application of the above in the synthesis of following compounds: Aromadendrene. 3h V. 4-. Oxford University Press. 1st. 11. March. John Wiley & Sons. Warren. N. C.3-difunctionalised compounds. L. Asymmetric synthesis and asymmetric induction.III. carbonyl compounds and alkenes. Furhfop and G. 6. Advanced organic chemistry Part B. Ireland Prentice-Hall India. 7. 4th Edn. 2001. Stereoselectivity: classification. Organic chemistry Vol.Principle and applications. New Age. I. 12. Willis and M. Norman and J.. Verlag VCH. 1999. 13. Advanced organic chemistry. E. D. 2nd Edn.βunsaturated compounds. S. C-403 OC Organic Synthesis-II 52 Hours I. New Delhi. 2. Micheal addition and Robinson annelation. John Wiley.. 1994. Organic synthesis: The synthon approach. Organic Chemistry. Potapov. S. vitamin-D. 9. 2008. Sundberg. 1983. terminology and principle. reserpine. 1975. 1987. Plenum Press. 1984. Cambridge Uni. W. 2. 14. Double diastereoselection and double asymmetric induction. Nasipuri. Mander. Blackie Academic & Professional. Edn.5. Moscow. H. M. 6th Edn. 4. L. 2nd Edn.. carbonyl compounds condensations. A. 8. Stereochemistry of carbon compounds. D. SUGGESTED BOOKS 1. 10. 1. 3. and 3-. Wills. John Wiley & Sons. Organic synthesis: Concepts. Press London. Some modern methods of Organic Synthesis. α. E. Ring Synthesis Synthesis of saturated heterocycles.difunctionalised compounds. R. Finar. longifloene. R. Designing organic synthesis: A disconnection approach. New York. F. Carrey and J. 5. 4h 76 . Stereochemistry of organic compounds. juvabione. Stereochemistry. advantages of polymer supported reagents and choice of polymers. alpine-borane. Ionic-liquids: Introduction. III. alkylation.DET in asymmetric epoxidation. Enantioselective Michael addition. Sonochemical esterification. alkylation. Addition of allylmetal and llylboranes to carbonyl group. reaction vessel/medium. 6h II.2. Diels-Alder reaction. Use of Microwaves: Introduction.and 1. oxidation. N-alkylation and alkylation of active methylene compounds. Oxidation of alcohols and sulfides. instrumentation. addition. Enantioselective intramolecular aldol condensation. . Polymer supported reagents in organic synthesis 6h Introduction. substitution.Acyclic stereoselection: Addition of nucleophiles to carbonyl compounds (1. 3h Diastereoselection in cyclic systems: Nucleophilic addition to cyclic ketones (formation of axial and equatorial alcohols. synthesis and applications of some important ionic liquids in organic synthesis. atom efficiency (% atom utilization). concept. 4h Enantioselective alkylation of ketones via hydrazones. Synthesis of polymer bound per acid and its applications. Reagent linked to a polymeric material: Preparation of sulfonazide polymer and application in diazotransfer reaction. Use of (+). Applications: Substrate covalently bound to the support: Synthesis of oligosachcharides. (S)-BINAL-H. (-)i BOAlCl2. structure.4asymmetric induction). specific effects. catalytic hydrogenation. Synthesis of polystyryl boronic acid and use in diol protection reaction. Enantioselective alkylation with chiral PTC. Preparation polymeric n-butyl. Asymmetric amplification. and (S.and (–).triphenylphosphonium bromide and its use in Wittig reaction. 77 . Dieckmann cyclisation. Preparation of polymer bound aldehyde and application in aldol and Wittig reactions. solid-state Edman degradation. Polymer-bound chiral catalysts in asymmetric induction.1. condensation of active methylene compounds with aldehydes and amines. Deprotection of esters and silyl ethers. Polymer supported catalytic reactions: Preparation of polymer supported AlCl3 and application in etherification and acetal formation reactions. Asymmetric aldol condensation. (R.R)-DIOP.S)-CHIRAPHOS).properties of polymer support. Use of ultrasound and Microwaves in Organic Synthesis 6h Use of ultrasound: Introduction. diastereoselective oxidations and stereoselective cyclization of poylenes). reduction and coupling reactions. advantages and limitations. 3h Enantioselective synthesis: Reduction with chiral hydride donors [(S)-PBMgCl.3. 2h IV. the phenomenon of cavitation. New Delhi. phenenthrene. Mander. Synthetic insecticides: Introduction. and [18]-annulenes. oxidation and reduction reactions. Types of phase transfer catalysts and reactions and their Advantages. alkylation. chlordane. hormones (juvenile hormone). Generation and application of superoxide anions. Cambridge Uni. Synthetic applications: Alkylation. DDVP. Nasipuri. precocenes. E. beygon. molluscicides and rodenticides. Crown ethers: Introduction. diazenon. mode of action and synthesis of chlorinated insecticides (DDT. New Age. Stereochemistry. D. perylene. VI. VII. features. cycloheptatrienium cation. L. Polycic aromatic compounds: Introduction. 9. 4. nomenclature. acaricides. Stereochemistry of organic compounds. insect repellents. S.V. coronene and lapachol. Introduction to the use of the following in the control of pests and insects: Fumigants. 4th Edn. MIR. Some modern methods of Organic Synthesis. preparation of anthracene. 6. March. naphthacene. [10]-. 2. Advanced organic chemistry. 2001. nature of donor site. D. [14]. 7. parathion. G D Lin. addition. synthesis of cyclopropenyl cations. Wilen and L. definition. Naturally occurring insecticides: Rotenones. N. 5. Moscow. H. Cation deactivation reactions. cyclooctatetraenyl dication. General synthesis of Crown ethers. A textbook of organic chemistry. Y M Li and A S C Chan. 20-methylcholanthrene. Organop[hosphorous insecticides: Malathion. Narosa Publishing House. SUGGESTED BOOKS 1. 78 . classification.Principle and applications. Pesticides and insecticides 6h Introduction. Carbamate insecticides: Sevin. 3. W. Ahluwalia and M. 2nd Edn. 1975. nematicides. John Wiley. nomenclature. New Age International Publishers. Organic Chemistry. 2nd Edn. 1998. R. aldicab. 1984. Caruthers. chrysene. Nonbenzenoid and polycyclic aromatic Compounds 6h Nonbenzenoid aromatic compounds: Introduction. Stereochemistry of carbon compounds. heptachlor and hexachlorocyclohexane). John Wiley & Sons. carbofluron. Goyal. Reactions of anthracene and phenanthrene. 2001. Press London. J. Preparation of catalysts and their application in substitution. Nasipuri. mechanism of phase transfer catalysis. 2008. cyclopentadienyl anions. Principles and applications of asymmetric synthesis. 1994. classification.. Wiley Interscience. V. Phase transfer catalysis and Crown ethers 6h Phase transfer catalysis: Introduction. pyrethrins. azulene and their reactions. New Delhi. 2000. Stereochemistry. E. 8. 1999. elimination. K. Ireland Prentice-Hall India. pyrene. Potapov. Eliel. generation of carbenes. aromatic substitution and displacement reactions. cyclobutadienyl dications. Barton reaction for the synthesis of aldosterone. 2nd Edn. 1981. Factors governing drug design. Computer-aided drug design and molecular modeling. 12. penicillins. 6th Edn. Wiley. Weber. position of angular methyl and stereochemistry of ring junctions). Narosa. M. Physicochemical parameters: lipophilicity. The Royal Society of Chemistry. rate theory. partition coefficient. Steroids Occurrence. 1977. 2002. 1980. S.. C-404 OC MEDICINAL ORGANIC CHEMISTRY 52 hours I. Narang and R. G. Diels hydrocarbon and stereochemistry. agonists and antagonists. Isolation. C. Springer. V. Antibiotics Chemistry (structure elucidation. Rational approach to drug design. Green Chemistry. Macrocyclic Polyether Chemistry. pharmacodynamics. 18. W. Nomenclature. induced-fit theory. Royal Society of Chemistry. Sanghi and M MSrivastava. Dehmlov. L.10. Quantitative structureactivity relationships (QSAR). ED50. Gokel. NY. 16. Factors governing the enhancement of biological activity of drugs. structure and structural elucidation of sterols and bile acids (determination of ring size. stereochemistry. K. 1987. Narosa. G. 1983. Pharmacokinetics. 1992. ID50.. Longman. cephalosporin-C and tetracyclins (terramycin and aureo-mycin Interconversion of penicillins to cephalosporins. E. 8h 79 . N. progesterone. Ahluwalia and R. Sex hormones and corticosteroids. Gokel. generics and analogs. Theories of drug activity: Occupancy theory. Concept of drug receptors. Monograph.vitamins D. IC50 (mathematical derivations excluded). V. Finar. W. 1991. Hansch equation. Academic Press. 13. 17. 14. hard and soft drugs. Photo products of ergosterol. Phase Transfer Catalysis. I. W. NY. Verlagchemie. 1978. 2003. Pharmacodynamics. environment friendly alternatives. norsteroids and oral contraceptives. Wienheim. Mathur. Aggarwal. 12h III. Marker degradation. and aureomycin to tetracycline. K. Phase Transfer Catalysis in Organic Synthesis. General principles of drugdelivery: principles of dosage form design and drug administration. E. W. New Delhi. S. UK. Synthesis of (dl)-norgestrel and ethinyl oestradiol. Polymers as aids in Organic synthesis. Green Chemistry-an introduction text. Organic chemistry Vol. B. Iso-sterism and bioisosterism. Theories of drug activity& Drug design Classification and nomenclature of drugs. Williams. R. Generics and analogues. Drug toxicity testing: LD50. Vol 1 to 3. androsterone. testosterone. G. Korzeniowski. Brief discussion of homosteroids. metabolites and antimetabolites. Pharmacokinetics. 11. S. Dehmlov. reactions and synthesis) of streptomycin. 15. K. New Delhi. Synthesis of cholesterol. 2. Gokel. prodrugs and active pharmacodynamic agents. nature of side chain. Berlin. basic skeleton. 2003. Crownethers & cryptands. estrone. Organic synthesis: Special techniques. Elementary treatment of drug-receptor interactions. 10h II. The Organic Chemistry of Drug Design and Drug Action...& B. Synthesis of amyl nitrite. III Ed. Hormone and natural products. neurochemistry of mental diseases. Wilson and Gisvold's Text Book of Organic Medicinal and Pharmaceutical chemistry. drug inhibitors of peripheral sympathetic function. dapsone. Direct acting arteriolar dilators. ciprofloxacin. cardiovascular diseases. N Weaver. Instant Notes Medicinal Chemistry. Academic Press. Viva. 7. methyldopa. Oxford. special problems. mode of action of hypnotics. Lippincott. 1-6 Ed. griseofulvin.the neuroleptics. T L Lemke and D A WilliamsEds. An Introduction to Medicinal Chemistry. cancer chemotherapy. antidepressants. Abraham. Vols. 80 . anti-anxiety drugs. Antipsychotic drugs.IV. neurotransmitters.. novalgin. 2003. P Graham. general anaesthetics. Antivirals : Acyclovir. 12h Local anti-infective agents: Introduction and general mode of action. melaphan. Wiley.. atenolol. Mechanism of drug action and synthesis of the following classes of drugs. ethosuximide. alprazolam. 2007 3. Cardiovascular drugs: Introduction. 2003 2. Medicinal Chemistry – G R Chatwal. phenacetin. rimantidine and zidovudine. ethionamide. A Kar. 2000. John Wiley. Synthesis of mechlorethamine. Jr. D. paracetamol. stereochemical aspects of psychotropic drugs. 6. isoniazide. Foye’s Principles of Medicinal Chemistry. Goodman and Gilman's Pharmacological Basis of Therapeutics. oxrprenol. cyclophosphamide. Synthesis of diazepam. 8. aminosalicyclic acid.chains of insulin. CNS depressants. P Graham. uracil mustards and 6-mercaptopurine. Eds. Amsterdam. phenytoin. barbiturates. 11th Edn. J H Block and J M Beale. 6th Edn. central intervention of cardiovascular output. Oxford. chlorazepam. sorbitrate. R B Silverman. New Delhi. Himalaya. glibenclamide. Synthesis of sulphonamides. Williams and Wilkins.. benzodiazepines. 10h SUGGESTED BOOKS 1. chloroquin and primaquin. metformin.J. analgesics and non steroidal anti-inflammatory drugs: Aspirin. quinidine. amantidine. ciglitazone. Mention of carcinolytic antibiotics and mitotic inhibitors. TataMcGraw-Hill.. 2002 10. serendipity and drug development. butyrophenones. role of alkylating agents and antimetabolites in treatment of cancer. Antihistamines: Methapyrilene. 2005. econozole. with recent developments: Antipyretics. 2004. Antineoplastic agents: Introduction. Psychoactive drugs. ethambutal. fluconazole. nalidixic acid. sedatives. diltiazem. Recent development in cancer chemotherapy. buspirone. Medicinal Chemistry. 2002 9. thiopental sodium.chemotherapy of the mind: Introduction. glutethimide. 2006 4. Burger's Medicinal Chemistry and Drug Discovery. New Delhi.II Edn. trimethadione. Medicinal Chemistry. Williams and Wilkins. Antidiabetics: Sequence of A. furazolidone. 2006 5. oxazepam. phenylbutazone and ibuprofen. verapamil. chlorpheniramine. Lippincott. Synthesis of stilbene. S. Strategies for Organic Drug Synthesis and Design. Academic Press. 14.I. Synthesis of 2. Total synthesis of natural products: The chiral approach Vol. R. 12. Ito. S. London. UK. V.Tetrahydrocarbazole 15. Spectral data of natural products Vol. D. K. Scott. 9. Medicinal natural products: A biosynthetic approach. Ollis. S. Himalaya. S. Jerusalem. Pandey and J. B. Goel Publishing House. H. Chemistry of natural products Vol. Vol. Dewick. Biosynthesis of ethanol from sucrose. An Introduction to Drug Design. Nakanishi. New Age International. Goso. 22. NY.3. Generation of benzyne and its trapping with tetracyclone. 21. 7. Dimmock. 1995.1998. Barton. 24. 5 (Antibiotics). Preparation of benzpinacolone from benzophenone. Nozoe. I. Organic chemistry Vol. Diels-Alder reaction of anthracene with maleic anhydride 16. Natural products chemistry Vol. Chichester. 1997.K. Synthesis of benzocaine from 4-nitrobenzoic acid. New Delhi. Preparation of tetraphenyldihydrophthalic anhydride from N-phenylglycine. Total synthesis of steroids.3-diphenylquinoxaline 81 . 1999. 1992. Akhaun & Titov. Synthesis of Methyl Red 12. Chatwal. W. D. 1983. 6.2. 11. Preparation of NBS from succinic acid and its application in allylic bromination reactions. 25. Elsevier Publishing Co. J. Natural Products Chemistry Vol 1 and 2. Aggarwal. A. Banthorpe & J. Pergamon Press. 8. 16. P. New Delhi. Hobbs. 1994. Preparation of 2. Oxford. M. Interpretation of the UV spectra of natural products. Anthrone from Anthracene. John Wiley. 1974.4. John Wiley.4. Synthetic drugs. Himalaya. 23. G. 1. 17. Hanessian Pergamon Press. 1983. D.11. S. 6th Edn. D. T. PRACTICALS (4 days a week. Pergamon Press. 1964. 13. 1969. 1982.S. O. 20. 1990 15.R. 1979. 1970. R. Natori & S.5-triphenyloxazole from benzoin 10. Natural products: Their chemistry and biological significance-J. Comprehensive Organic Chemistry. S. Preparation of 2-phenylindole from phenylhydrazine 5.II. Synthesis of 1-bromo-2-naphthol from 2-naphthol 13. P. Finar. Mann. I. L. Davidson. Hanessian Pergamon Press. Synthesis of Hippuric acid 14. 3. R. B. 19. Longman.III. I & II. I & II. NY.III I – PREPARATIONS 1. Total synthesis of natural products: The chiral approach Vol.Yamaguchi. Longman. G R Chatwal. Harborne.III. 4. 2. 6th Edn. Lednicer. 18. 4 ½ hours a day) C405 ORGANIC CHEMISTRY PRACTICALS . C106/206/306 (Organic Practical – II).EXTRACTIONS AND SEPARATIONS (Preliminary Chromatographic Techniques) Extractions 1. Openshaw. Estimation of Nitrogen by Kjeldahl’s method.QUALITATIVE ANALYSIS Separation of a binary mixture of organic compounds and identification of the separated components by systematic qualitative organic analysis. Structural elucidation of organic compounds with the help of spectra provided by the instructors/examiners. 3. Estimation of an acid in presence of an amide. Press. SUGGESTED BOOKS 1. C406 ORGANIC CHEMISTRY PRACTICALS I . Text book of practical organic chemistry. 2. Univ. 2004. 4. Separation of p-rosaniline and methyl red by column chromatography. D. Pearson. Hirley.406 (Organic Practical – IV). 3. Preparation of organic intermediates. 2. John Wiley. A. Separation of carbohydrates by thin layer chromatography. IR. 4. Estimation of an ester in the presence of an acid. 3. Extraction of piperine from pepper. 1999. 2. A. Semi-micro qualitative organic analysis. 5. I to X. A laboratory manual of qualitative organic analysis. Vogel. Organic Synthesis collective Vols. II. Extraction of azelaic acid from caster oil. Extraction of caffeine from tea leaves. 2. Delhi. Estimation of Nitro group by reduction using SnCl2. NMR and GC-MS/mass spectra of the compounds prepared in C-105/205/305 (Organic Practical – I). 82 . 4. C-405 (Organic Practical – III) and C. Cheronis. 3. 2. Separation of amino acids by paper chromatography. I. Extraction of (+)-limonene from citrus rinds. 1956-1999. III – QUANTITATIVE ANALYSIS Estimations: 1. Entrikin & Hoanett. H.T. Recording/predicting/downloading from web sites the UV. Separations 1.II-INSTRUMENTAL METHODS IN ORGANIC ANALYSIS 1. 5th Edition. galvanizing. Himalaya Publishing House. Fieser. 83 . methods of preparation and applications. 8 hrs II. porosity. 2000. chromating. Ahluwalia. R.6. Laboratory manual. Mohan. B. Ramesh Chandra and Renu Aggarwal. Methods of corrosion prevention: Cathodic and anodic protection – corrosion inhibitors. Corrosion and its prevention About corrosion: Theories and mechanism of corrosion – thermodynamic and kinetic approaches to the study of corrosion – methods of determination of corrosion rates – Tafel extrapolation. Natural products. Advanced practical organic chemistry. 2005. 11. Allied Publishers. adhesion. Mahapatra and A. Laboratory Techniques in Organic Chemistry. Practical organic chemistry F. I K international Publishing House. Dhingra. Heath & Co. D. Aggarwal. Universities Press (India). 2002. Calcutta. organic finishes and industrial effluent treatment. K. 8. K. 2000. 1992. Longman. Testing of electrodeposits: Principles of the measurement of coating thickness. 2nd Edn.Ni. B. V. Techniques of electroplating: Galvanostatic and potentiostatic techniques – elementary account of electroless plating. Dey. 7. F. 1992. C. linear polarization and impedance techniques. New Delhi. B. anodizing. Comprehensive practical organic chemistry: Qualitative analysis. Ahluwalia. A.Cr – Zn plating – electroplating for electronics (Ag & Au) . 2000. 2005. V K Ahluwalia. 2000. Intermediates for Organic Synthesis. New Delhi. 10. L. corrosion resistance. FOURTH SEMESTER PHYSICAL CHEMISTRY SPECIALISATION C-401 PC APPLIED ELECTROCHEMISRY 52 Hours I. Pooja Bhagat. Saunders 4th Edn. Pooja Bhagat and Renu Aggarwal. 9. 15. phosphating. USA. Practical organic chemistry (Quantitative analysis). New central book agency. Ghoshal. reflectance and hardness – surface analysis of coatings by XPS and AES. Vol. J. New Delhi. Nad. I and II. K. Universities Press (India). V K Ahluwalia. V. 12. Ikan. M V Sitaraman and T. An advanced course in practical chemistry. Metal finishing Electroplating: Technological importance – theories and mechanism of electroplatingeffect of plating variables on the properties of electrodeposits – comparative account of complexing and non-complexing baths (general treatment) – additives in the plating bath – significance. C. 14. R.selective coatings – characteristics. Solar. 13.G. I K international Publishing House. Comprehensive practical organic chemistry : Preparation and quantitative Analysis. S. Govindachari. 1974-2000. Organic experiments. Metallic Coatings: Surface preparation – electropolishing – electroplating of Cu. Mann and B. Chronomethods: Basic concepts. Electroanalytical methods Voltammetry at a dropping mercury electrode(DME): Review of the principles of normal dc polarography – types of currents obtained at a DME – Ilkovic equation and its application – current-potential relation for a cathodic process – half-wave potential – tests for the reversibility of a process – irreversible processes at a DME – factors that set the sensitivity and selectivity limits in normal dc polarography. Batteries: Classification – characteristics – voltage. energy efficiency. shelf life. Hydrodynamic electrodes: Construction and use of rotating disc and rotating ring disc electrodes in the study of electrochemical processes. chronocoulometry and chronopotentiometry. Fuel cells: Classification – alkaline fuel cells. cycle life. silver oxide-Zn batteries. advantages and applications. Electrochemical energy conversion and storage Efficiency: Efficiency of electrochemical energy conversion vis-à-vis thermal conversion (Carnot limitation).Passivity: Characteristics – Flade potential – theories and mechanism of passivation – transpassivity – use of ellipsometric technique in the study of passivating films. energy density. 15 h IV. solid polymer electrolyte fuel cells. quasi-reversible and irreversible processes – study of coupled chemical reactions like ErCr. Stripping analysis: Hanging drop mercury electrode (HDME) – principle and applications of cathodic and anodic stripping voltammetry. 10 h 84 . electricity storage density. Ni-Cd. Electrochemical supercapacitors: Brief description. reactions and uses of Leclanche’ dry cell and metal-air batteries. current. capacity. Spectroelectrochemical techniques: Principle and application of transmission IR spectroelectrochemical technique. 10 h III. CrEr and ErCiEr. phosphoric acid fuel cells. Modified polarographic techniques: Tast polarography – normal pulse polarography – differential pulse polarography – ac polarography. reactions during charge-discharge and applications of Pb-acid. Secondary batteries: Construction. Lithium batteries: Primary and secondary lithium battery – lithium based conducting polymer batteries. methodology and applications of chronoamperometry. molten carbonate fuel cells and solid oxide fuel cells – brief description. reactions and applications of each type of fuel cell. Cyclic voltammetry: Principle – experimental set up – quantitative analysis – determination of diffusion coefficients – diagnostic criteria for reversible. Primary batteries: Construction. power density. Electroanalytical Chemistry by B.V. New York (1987). John Wiley & Sons (1968). Lithium battery technology by H. Fuel Cells by Bockris & Srinivasan. Cleven Hume. 15. Oxford & IBH Publishing Co. transmembrane potential. Electrochemistry by S. New York (2001).New Delhi(1983). Corrosion Engioneering by Mars Fontanna. Electrochemistry – Principles. 13. Vassos and G. Methods and Applications by Christopher M. John Wiley & Sons (1987). Brett. 11. 16. 2. Electrochemical Methods – Fundamentals and Applications. bioelectroanalysis. R . 14. Two examples of electroinorganic synthesis. temperature. supporting electrolyte. Industrial Electrochemistry by D. John Wiley & Sons (1981).. 12. McGraw Hill. Hyderabad (2002).. Electrochemistry by Potter. 85 . W. An introduction to Metallic Corrosion and its Prevention by Rajanarayan. Polarography and Allied Techniques by V.. Pletcher and F. Synthetic Organic Electrochemistry by A. Chemical and Electrochemical Energy Systems by Narayan & Viswanathan. 4. anodic. H. Plenum. Oxford University Press.. N. By A. A. Basics of Electroorganic synthesis byDemetrior K. electroporation. J. Faulkner.Y (2000). Hyderabad. C. Classification: Syntheses involving cathodic. Chapman & Hall. Bard and L. 6h VI. electrode potential. Christensen and A. Enzyme electrodes. London (1961). 6. London (1984). Oxford & New York (1993). John Wiley & Sons Inc. 7. agitation ) in electroorganic synthesis. V. 17. 2nd ed. 5.(1998). 2nd Edition. Suryanarayana Rao. bilayer lipid membranes. Hammett. Universities Press (India) Ltd. Riley and C.(1984). 3rd ed. Glasstone. One or two typical examples of each type of reaction. Fry. Principles of Electroanalytical Methods by T. Fundamental Principles in Modern Electrochemistry by Lowenheim. Chapman & Hall. Cambridge (1990). Ana Maria and Oliveria Brett. East-West Press. Venkatasetty. Techniques and Mechanisms in Electrochemistry by P. Walsh. 8. Universities Press (India) Pvt. M. 9.. Modern Electrochemistry – Vol 1. New Delhi (1985). New York (1983). Tomlinson (Analytical Chemistry by open learning).. 19. Electroorganic synthesis Description: Special features of electroorganic synthesis as compared to conventional synthesis – reaction variables (electrode material. The nerve impulse. 3. John Wiley & Sons Inc. John Wley & Sons (1972). Kyriacon. Ltd. Ewing. 10. paired. phase-transfer catalysed and electropolymerisation reactions. Bioelectrochemistry The electrochemical interface between biomolecules. A. John Wiley & Sons. bioelectrocatalysis. 3h SUGGESTED BOOKS 1.2A&2B by Bockris & Reddy. solvent. cellular membrane. 18. Wiley (1989). crystallanity and molecular weight on mechanical behavior of polymers. IV. Chemical potential of macromolecular solution. (iii) Sedimentation velocity (iv) sedimentation equilibrium. alternating. coordination polymerization. Expressions for models postulated for the shapes of macromolecules in solution: spheres. branched and cross linked polymers. Donnan membrane equilibrium. random. polyaddition. Step polymerization: polycondensation. organic and inorganic polymers. states of phase. Synthetic High Polymers: 14h i) Chemical and Geometrical Structure of Polymer molecules:Polymer micro structure. block and graft copolymers. 86 . Tm and Tf : Characteristics and evaluation of Tg. ellipsoid. ring opening polymerization and miscellaous polymerization. Thermodynamics of polymer solution: 4h Partial molar and partial specific quantities. Gibbs – Duhem equation. Tg and molecular weight. (v) density gradient sedimentation (vi) viscosity (vii) electrophorises. concepts of second viral coefficient and excluded volume. Ziegler-Natta catalyst. Molecular weight determinations: 10h Determinatiopn of molecular weight average by (i) Osmotic pressure. Stereo regular polymers: Optical isomerism and geometric isomerism. group transfer polymerization II. III. long rod and flexible random coil. factors influencing the Tg. Derivation of relevant exopression in each case. Polymerization process: 9h Chain polymerization: Free radical polymerization: initiation. (ii) light scattering. Ionic polymerization. Electrochemical polymerizarion: Matathetical polymerization. inhibitors. Effect of temperature. Tg and melting point. Tm and Tf in accordance with crystalline and amorphous polymers. Tg and plasticizers. Importance of Tg. Use of these methods in evaluation of shapes and confirmations of macromoleuclaes. i) Tg.C-402 PC PHYSICAL CHEMISTRY OF MACROMOLECULES (ELECTIVE) 52 Hours I. ii) Glass Transition temperature: States of aggregation. homo chain and hetero chain polymers. chain transfer. homopolymers and copolymers. Microstructures based on geometrical structures: linear. propagation and termination. transitions and associated properties. H. Theoretical modeling of nanoparticles. 2. Photo fragmentations. Bulk to nano transition.Sperling. Ashraf. Geometric structures.R. oxidative and UV-stability. ORD and CD techniques.M. NMR. Gupta. C -402 PC NANOMATERIALS (Elective) 52hours I. 1990. crystallanity. photodegradation. New Delhi. G. Challenges of nanotechnology: and nanomaterials. Stability and Environmental issues: 5h Thermal degradation. Management of plastics in the environment. N. L. Mechanical degradation. Mechanism of Deformation. Transient testing and Impact testing. Spectroscopic studies of Macromolucules: 5h Determination of structure of macromolecules by UV-Visible. Introduction: Introduction and definition of nanoparticles nanotechnology. I.Fried (Prentice hall) New Delhi 1999. 87 .Gowariker. Anil Kumar and S.Viswanathan & T. Coulombic explosion. Text book of polymer science: F. conclusions. Principles of polymer chemistry-P. Fundamentals of Polymer science and Engineering. Degradation.V. stress-strain curves. Principles of polymerization. Wiley-Interscience. Super fluid cluster. Polymer science: V. Tata Mc-Graw hill-LCUE Series. Magnetic clusters. Introduction to Physical polymer science. plastic deformation (Rheology). J. Cornell Univeristy.Odian. degradation by ultra sonic waves. Reactivity.K.W. SUGGESTED BOOKS 1. A Laboratory Manual of Polymers.Flory. Chemical methods. thermolayers. molecular cluster. 1994. Rare gas and molecular clusters: Inert-gas cluster. Emergency 2h of II. 5. Semiconducting nanoparticles: Optical properties. 4. Methods of synthesis: RF plasma.Wiley). 3rd edition. New York 1992. S. Electronic structures.R. London.Sreedhar (Wiley Eastern) New Delhi. chemical resistance. New York (1986). Press Ithaca (1953). Recycling. International Publishing House Pvt. Infrared. Magic numbers .Ltd. 7. IV. Properties of individual nanoparticles: 20h Metal nanoclusters. 8. Mechanical properties: 5h Structure property relation ship of polymers: Strength.J. Polymer Science and Technology. III. pulsed laser methods.Billmeyer (John. New Delhi (1978).II. radiation effects. Wiley Interscience. 6. 3.K.Poissons ratio. Incineration and bio degradation. 2009. Fluctuation. chemical and hydrolytical stability. Sharif Ahmad and Ufana Riaz. Methods of testing: Static testing. physical state of polymers. Application: Infrared detectors. 2005. SUGGESTED BOOKS 1. 5. carbon clusters-small carbon clusters. Conductivity. V.entropy of activation. I. 10h II. electrical properties. Conduction electron and dimensionality Fermi gas and density of states. International. New carbon structures. Strucure of C60 and its crystal. Manasi Karkare. potentials wells partial confinement. 4. 2008. Dehydrogenation of ethane. and nanowires structures. 2008. Special nanometerials: 20h Carbon molecules. Swain-Scott and Edward equations. Linear Free Energy relationships (LFER): Thermodynamic implications of LFER. Inida. Vibrational properties. Publishing House Pvt. Hammett and Taft equations. 88 . Winstein Grunwald relationship. Bangalore. metal oxide. Inductive and electromeric effects on reaction rates. properties dependent on density of states. Effect of substitutents on activation energies.. Charles P.III. New Delhi. Poole Jr. Bhat. Imperial College press. Quantum dot lasers. Guozhong Cao. Organic and inorganic hybrids: Class I and Class II Hybrids. Core shell structure. Quantum wells. Reaction mechanisms Importance and general approaches of reaction mechanism. intercalation compoundsNanocomposites and nanograined materials. 2004. Kinetics and mechanisms of. wires and dots: 10h Introduction. 3.Decomposition of N2O5. significance of volume of activation. Wiley-India Edition. University of Washington. Influence of solvent on reaction rates (double sphere model). Mick Wilson. crystalline micro porous materialsZeolites. single electron tunneling. Micro and mesoporous materials: Ordered and random mesoporous structures. Nanotechnology Fundamentals and Applications. Reactions in solution Cage effect. Overseas Press. Narosa Publishing House. other bucky balls. Carbon nanotubes.K. S. Frank J. Alkali doped C60.. size effects. size and dimensionality effects. C-403 PC REACTION KINETICS AND MECHANISMS 52 Hours I. preparation of quantum nanostructures. metal polymer and oxide polymer structure. Volume of activation. Ltd. Hypohalite-iodide reaction. Primary and secondary isotope effects on reaction rates. Nanostrutures and nanomaterials. Diffusion and activation controlled reactions. ‘Introduction to Nanotechnology’ (2nd Edition). Mechanical properties. Biometerials (2nd Edition). Michelle Simmons. Nanotechnology. Burkhard Raguse. USA. discovery of C60. Kamali Kannangara Geoff Smith. Reaction between gas phase and solution phase. Owens. IV. Halogenation of acetone. Excitations. Delhi. Isokinetic relationship-Evaluation of isokinetic temperature and its significance. nature of the carbon bond. 2. 2005. Larger and smaller Fullerenes. Quantum mechanical tunneling..Jain (Vishal Publications) 1982.) New Delhi. Text Book of Polymer Science. Acidity functions. Pharmacokinetics Basic considerations. R. calculation of elimination rate constants.Billmeyer (Jhon Wiley) 1984.Pearson (John-Wiley) New York. Chain and complex reactions Introduction. one compartment open model. Chemical Kinetics. Mean free path.C. 5. Role of surfaces in heterogeneous catalysis.Kapoor (Mc.Introduction.F. 9. Laidler 3rd Edition (Mc-Graw Hill Inc. S.Misra (Wiley Eastern Ltd.Mukheji. 1993.. G. S. Kinetics of Branched chain reactions. 1978. Reaction rates and cross sections. Ru(III) chloride catalyzed oxidation reactions of alcohols and aminoacids by chloramine-T in acid and alkaline media. Reaction Mechanism in Organic Chemistry. Organic Reaction Mechanism. 3.M.Billing and Milkelson (Wiley Interscience). Molecular reaction dynamics Reactions in molecular beams.P. 1962.Bansal (Mc-Graw Hill) New Delhi.Singh and R. 89 .D. 8h SUGGESTED BOOKS 1.K. Objectives. Frost and R. Catalysis. rate laws. Kinetics of Chemical Reactions. Mechanisms of N-haloamines. Plasma drug concentration time profile. 9h V.S.J. 8. Atkins (Oxford) 2004. catalytic coefficients and decomposition constants.Kuriacose (McMillan India Ltd. 7th Edition.Objectives and enhancement of bioavailability. catalyst inhibitor and catalyst poison.Intermediate compound formation theory and adsorption theory. K. Bangalore) 1978. Protein binding of drugs. 6. Oxidation of malic acid by bromate ion catalysed by Ce(III).Relationship between the rate constant and acidity function. Reaction co-ordinate.catalyst carrier. Kinetics of catalyzed reactions Heterogeneous catalysis. J. Introduction to Molecular Dynamics and Chemical Kinetics. Theoretical calculation of activation energies of potential energy surfaces. catalyst promoter. Physico-chemical factors affecting bio-availability. P. Microscopic reversibility.. Compartment modeling: Introduction. Physical Chemistry. 4. Oscillatory reactions. 2. 10. Drug dissolution rate. potential energy surface for H+H2. Pharmacokinetic and Pharmacodynamic parameters. H2-O2 reaction explosion limits.P. 1996. Kinetics and Mechanism. 2007. Industrial catalysts.W.Millan India Ltd.Pyrolysis of butane and.K. Deduction of reaction mechanisms. Kinetics and mechanisms of polymerization reactions-Addition (Free radical. Production and identification of free radicals. Factors affecting protein-drug binding. 7. Transmission co-efficient. Nucleophilic and electrophilic substitution reactions.) New York. Introductory Polymer Chemistry.G. 10h III. Kinetic orders of reactions. Role of surfaces in heterogeneous catalysis. Symmetry numbers and statistical factors. Bioavailability. G. Anionic and Cationic) and Condensation polymerization 7h IV.) 1991. 8h VI. Kinetics of protein-drug binding. W. S. lattice water.A. 3rd Edition. 1960.Barrow. Statistical Thermodynamics. 5th Edition . Comprehensive Chemical Kinetics. 18. Koopman’s theorem. Benson (Mc-Graw Hill). mono and multinuclear carbonyl complexes. Auger electron spectroscopy and applications.11. 1998. chemical shift. 1992. Modern Physical Organic Chemistry-V. 2nd Edition. spectra of metal complexes: Ammine. House (Wm C Brown publisher).D. New York.Gupta (Wiley Eastern Ltd. cyanato and thiocyanato complexes. Nitrito. 1990.M. 1997.London. carbonato. University Science Books. Vibrational spectroscopy 9h Vibrational spectra of diatomic. nitrato. 1990.P. C-404 SPECTROSCOPY – III (Common to Inorganic and Physical Chemistry) 52Hours I. Lasers and their use in Raman spectroscopy III. Nath (Himalaya Publishing House).C. 1970. σ and π bands..Gilliom (Additions – Wesley) USA. J. AB5 and AB6 molecules. 1969. AB4.n. 20. Nitro. Raman spectroscopy 4h Resonance Raman Spectroscopy. AB3. Electron energy loss spectroscopy. cyano and nitrile complexes. linear and bent triatomic. (Tata-Mc-Graw Hill). hyper and inverse types.) New Delhi.D. Reaction Rates Equilibrium and Mechanisms.R. 17. N.G. Foundation of Chemical Kinetics. K-Upadyayay. 21.photoelectric effect. Photoacoustic spectroscopy Basic description and applications 2h IV. sulphato and other acido complexes. Nonlinear Raman effects-Stimulated. NMR spectroscopy of inorganic molecules Proton NMR spectra of metal hydride complexes 90 8h . 14.. Vol-I. amido. 13. 19. (Butterworths) . applications of core level spectra-ESCA..basic principles and applications Applications to the study of solids V. ambidentate ligands. 12. Photoelectron spectroscopy 8h Basic principles. Valence level spectra.E. Introduction to Physical Organic Chemistry.) 1970. 1977. phosphines and arsines. XPS and UPS. L. Physical Organic Chemistry. 16. USA (2006). nitrosyls.Gowrikar et al (Wiley Eastern Ltd.M. Eric and A. aquo and hydroxo. ethylenediamine and diketonato complexes II. spin-orbit coupling in core level spectra. Elementary reaction Kinetics.) New Delhi. Principles of Chemical Kinetics.Hammett (Mc-Graw Hill Book Co. Polymer Science. A Upadyayay. 15. Biophysical Chemistry-Principles and Techniques. Mumbai. Banford and Tipper (Elsevier Publishing Co.W. S. Physical Chemistry. Dennis. Boston.) New York. WileyInterscience. F2 and BH3. application to transition metal complexes (having one to five unpaired electrons) including biological molecules and inorganic free radicals such as PH4. Sathyanarayana. Kramer’s degeneracy. Nuclear Quadrupole coupling constants. Vibrational Spectroscopy: Theory and Applications. 3. 2. spin-orbit coupling and significance of g-tensors. Electronic Absorption Spectroscopy and Related Techniques. R. the position of ESR absorption. electronelectron coupling. 183W. X-ray absorption spectroscopy Near edge measurements and EXAFS SUGGESTED BOOKS 1. 2h 91 . 11B NMR spectra of simple compounds. ELDOR. Experimental techniques and applications XI. Drago.. electric field gradients. Interpretation of ESR spectra and structure elucidation of organic radicals using ESR spectroscopy. Physical methods in Inorganic Chemistry. Proton/hydride interactions with 103Rh. quadrupole splitting and magnetic hyperfine interactions. Nakamoto. D. VI.N. Affiliated East West Press Pvt. Sn2+ and Sn4+ compounds VIII. Solid State NMR. zero/non-zero field splitting. application to the study of bonding and structures of Fe2+ and Fe3+ compounds. K. Spin polarization for atoms and transition metal ions. Electron-nucleus coupling (Hyperfine splitting).NMR spectra of nuclei other than hydrogen: 19F. double resonance in ESR. Bangalore (2001). Ltd. VII.N. isomer shift. D. Sathyanarayana. Universities Press. 195Pt and 207Pb in metal complexes/organometallic compounds. Electron spin resonance spectroscopy 10h Basic principles. ENDOR. New York (1970). determination of ‘g’factor. Infrared spectra of Inorganic and Coordination Compounds. NQR spectroscopy 4h NQR isotopes. 31P. Mossbauer spectroscopy 5h Basic principles. New Delhi (2000). significance of ‘g’ factor. 4.S. ESR spectrometer. New Delhi (1965). Spin density and Mc Connell relationship. New Age International Publishers. Spectral Interpretation for structure elucidation of simple organic compounds (-COOH. 92 . SPECTROSCOPY 14 15 Absorption spectrum of a conjugated dye and verification of quantum mechanics of particle in a one dimensional box. -NH2 and-Cl) by FT-IR.C-405 PHYSICAL CHEMISTRY PRACTICALS . 7 Kinetics of decomposition of H2O2-effect of catalyst and promoter. energy of activation and thermodynamic parameters.ions. X-RAY DIFFRACTION STUDIES: 16 17 Powder diffraction pattern of simple salts and determination of lattice type and the parameters. Evaluation of cell parameters from rotation photograph. 4 Study of the kinetics of hydrolysis of t-butylchloride by conductivity method – determination of rate constant. -OH.determination of order with respect to each reactant by ratio variation method. 9 Kinetics of oxidation of indigo carmine by chloramine-T-Spectrophotometrically. Determination of Ea and Thermodynamic parameters. 5 Degree of hydrolysis of urea-hydrochloride from the study of acid hydrolysis of methylacetate. 3 Kinetics of oxidation of glycine by chloramine-T. Ea and thermodynamic parameters. PHOTOCHEMISTRY 18 Demonstration of Fluorescence of solution of Anthracene in benzene with the respective UV – visible absorption spectra. 8 Study of decomposition of diacetone alcohol using dilatometer . 12 Study the effect of salt (ionic strength) on the kinetics of the reaction between potassium persulphate and potassium iodide. 11 Study of the effect of dielectric constant using methanol on the kinetics of the reaction between a primary amine and CAT. 13 Kinetics of autocatalytic reaction between potassium permanganate and oxalic acid. 2 Determination of Ea for hydrolysis of t-butyl chloride by conductivity method. 10 Determination of catalytic efficiency of RuCl3 for the reaction between a primary amine and CAT. Determination of order of the reaction for hydrolysis of methyl acetate and evalutaion of activation parameters. determination of order with respect to glycine. 6 Study of acetone-iodine reaction .III (At least fifteen experiments are to be carried out) CHEMICAL KINETICS 1.Evaluation of catalytic coefficient of OH. Determination of pKa values of a polybasic acid pH metrically. 2. C 406 PHYSICAL CHEMISTRY PRACTICALS – IV (At least fifteen experiments are to be carried out) POTENTIOMETRY and pH METRY 1. 9. Differential potentiometric titrations: i) Weak acid against strong base ii) Mixture of strong and weak acids against strong base CONDUCTOMETRY 10. Conductometric titrations: (i) Thorium nitrate with potassium tartrate. 6. (iii) Acetic acid. Spectrophotometric determination of indicator constant (Bromophenol blue). Determination of corrosion rate of: (i) Zn in NaOH by weight loss method. Titration of ferrous ammonium sulphate against potassium dichromate using a bimetallic electrode. Determination of the free energy change of a cell reaction. 14. SPECTROPHOTOMETRY 13. 4. Determination of equivalent conductance of a weak electrolyte (acetic acid) at infinite dilution following Kohlarauch law. Determination of hydrolysis constant of aniline hydrochloride conductometrically. (ii) Potassium iodide with mercuric perchlorate. (CHCl3 – acetic acid – water). 3. monochloro acetic acid and trichloro acetic acid with strong alkali 11. 8. 7. method. Determination of mean-ion activity coefficient of HCl and the study of the effect of ionic strength on the activity coefficient of Ag+ ions. Determination of pKa values of a polybasic acid potentiometrically using quinhydrone electrode. 5. 93 acid and Mild steel in HCl by polarization . Determination of stability constant of a complex formed between salicylic ferric ion by variation of pH. Study of the complex formation and determination of the stability constant of silverammonia complex. Determination of the solubility of silver halides in a mixture.PHASE RULE: 19 To construct the phase diagram of a three component systems. 12. Determination of acid and base dissociation constants of an amino acid and hence its isoelectric point by pH metry. CORROSION 15. millan Publishers. Kosla. McGraw Hill International Edn.POLAROGRAPHY 16.(1966). Macmillan Publishing Co. 3. R. Salzberg. Experimental Physical Chemistry by Daniel et. (1968). Newcombe & others. POLYMER CHEMISTRY 18. C. a) Identification of metal ions in a mixture. New Delhi (1983). SUGGESTED BOOKS Findlay’s Practical Physical Chemistry revised by P. J. Delhi. Green. Physical Chemistry Laboratory Principles and Experiments by H. S.New York. James and P. Determination of molecular weight of a polymer by viscosity method. Atavale and Parul Mathur.S. Simla Printers. Senior Practical Physical Chemistry by B. Advanced Practical Physical Chemistry by J. b) Quantitative determination of electroreducible species. Goel Publication. Longman’s London (1966). Levitt. Pritchard. Practicals in Physical Chemistry. New York (1962). C. Morrow. Longman’s Group Ltd. New Delhi (2001). New York (1962). Behra. al. Experimental Physical Chemistry by R. (2006). 6. 11. Yadav. Meerut (1988). W. I. A Mordren Approach by P. E. 7. CYCLIC VOLTAMMETRY 17. 2. Tata McGraw Hill. Experiments in Physical Chemistry by Shoemaker and Garland. 5. Experimental Physical Chemistry by V. M. E. Sindhu. 10. B. Behra and B. 8. New Delhi (1987). McGraw Hill. D. Mac. Study of the redox behaviour of K4Fe(CN)6 / K3Fe(CN)6. New Age International. 1. Cohen and M.. Pergamon Press.. 4. B. 9.. Practical Physical Chemistry by A. Experimental Physical Chemistry by Wilson. 4885-BUP-200-Jan. 2010 94 . 95 .