Review ArticleCODEN: IJPRNK Swati Sabharwal, IJPRBS, 2013; Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE JASMINUM SAMBAC LINN (MOTIA): A REVIEW SWATI SABHARWAL, SWATI SUDAN, VADI RANJAN Department of pharmacy, Chandigarh group of colleges, Landran, Mohali. Accepted Date: 27/09/2013; Published Date: 27/10/2013 Abstract: Jasminum sambac Linn. (Family-Oleaceae) commonly known as Motia or lily jasmine is a scandent or sub-erect shrub with young pubescent branches, broadly ovate or elliptic, opposite leaves, white, very fragrant flowers cultivated nearly throughout the tropical and subtropical parts of the world. Traditionally plant is used in fever or cough, indolent ulcer, abdominal distension, diarrhoea, lowering the blood glucose level, regulating menstrual flow, to clean kidney waste, inflamed and blood shot eyes. Root, flowers, leaves act as lactifuge, arrest the secretion of milk in the puerperal state in case of threatened abscess. Pharmacological activities of the plant reported so far are antidiabetic, antitumor, antimicrobial, antioxidant, anti-acne, A.N.S stimulating effect. The present review is an attempt to highlight the various ethno botanical and traditional uses as well as phytochemical and pharmacological activities reported so far from J. sambac. Keywords: Jasminum sambac Linn, Traditional uses, Pharmacognosy, Phytochemistry, Pharmacological activities. Corresponding Author: Ms. SWATI SABHARWAL Access Online On: www.ijprbs.com How to Cite This Article: PAPER-QR CODE Swati Sabharwal, IJPRBS, 2013; Volume 2(5):108-130 108 Available Online at www.ijprbs.com Review Article CODEN: IJPRNK Swati Sabharwal, IJPRBS, 2013; Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS INTRODUCTION Jasmine is an essential oil bearing plant belongs to the family Oleaceae. The fragnant world of Jasmine comprises different varieties of bela, chameli and juhi. The distribution of the genus is wide but majority of the species were centred around India, China and Malaya. It comprises about 200 species. The critical analysis of the species position revealed the true species to be 89 (1). Sr. No. Name of the jasmine Common name species 1 Jasminum grandiflorum (L.) 2 Jasminum Linn. 3 Jasminum multiflorum Safed chameli Roth. 4 Jasminum Linn. 5 Jasminum heterophyllum Roxb. 6 Jasminum glandulosum Wall. J. dichotomum Subtropical Himalaya, Kumaon, Kharia Hills Akei and Lushai Hills Altitude 7002000 mtrs. 7 Jasminum angustifolium Vahl. Wild Jasmine Deccan Peninsula, south Travancore 8 Jasminum arborescence Roxb. Tree jasmine Tropical north west Himalaya, Deccan peninsula, Chota Nagpur, Orissa. 9 Jasminum androphyllum Wall. 10 Jasminum Chameli officinale Sweet jasmine humile Pili chameli Natural distribution Subtropical north west Himalayas, Nilgiri. Pulney and Tinny valley Hills Alt. 700-1800 meters Throughout India, common subhimalyan tract and moist forest in Western. Coast, Western. Ghats in the south kanara. Mysore, Malabar and Western. nilgiris Altitude 1300 mtrs North West Himalayas, Nilgiri Altitude 700- 2000mtrs Mishmi Hills Kashia Hills Joohi, jui North West India, Deccan Peninsula, Bengal, South Travancore and western 109 Available Online at www.ijprbs.com Kashia and Jaintia Hills. Temperate Himalaya. Coast. Volume 2(5):108-130 auriculantum Vahl. 17 Jasminum caudatum J. eretiflorum wt. Nilgiri Coimbatore. Nilgiri Hills. Deccan Peninsula in rain forest of southern Ghats of North Kanara. Assam. Walt. ovatum Walt. Walt. Tinnelvelly. South and middle Andaman 20 Jasminum dispermum Wall. 22 Jasminum malabaricum Wt. Alt 1000. Kashmir. 11 Jasminum anastomosans Wall. Cuttak South Deccan Peninsula.2500 mtrs 21 Jasminum flexile Vahl. azoricum J. Alt 01000 mtrs 19 Jasminum cardifolium J. South west India especially in Ghats 14 Jasminum braviloburn J. 12 Jasminum attenuatum Roxb. Khasia and Lushi Hills. Ghats in the South Kanara. reticulatum Walt. J. Ghats. Malabar. strinerve Roxb. Nilgiri Hills. Western Ghats. nilaglricum Pl. West Coast and Western Ghats in all districts up to 1700 mtrs. Roxb. 2013. IJPRBS.com . Altitude 200-1300 mtrs 13 Jasminum Backer. Assam. ISSN: 2277-8713 IJPRBS Ghats. 110 Available Online at www. Roxb. Annamalai and Tinnevely Hills. Forest in the pilibhit district of Rehil Khand and the kheri districts of upper gangetic plains 16 Jasminum calophyllum Wall. Pulney Hills Alt 10002000 mtrs 15 Jasminum brevipetiolum Duthe. Alt up to 1300 mtrs 18 Jasminum coaretatum J.ijprbs. Western Ghats. Kashia Hills. West Nilgiris. courtollense Wt.Review Article CODEN: IJPRNK Swati Sabharwal. Alt 1300 mtrs. Mogra Kashia Hills. Alt up to 1300 mtrs Western. Kashia and Mishmi Hills. Western. ) Ait. Mudgara. IJPRBS. the Jasmine particularly J. Kannada. Java. Andhra Pradesh. 2013. Chirakamulla . Chambeli. Sosan. Malli. (Family-Oleaceae) commonly known as Motia or lily jasmine is a scandent or sub-erect shrub with young pubescent branches. PunjabiChamba.sambac (L. Mollika. Chamba. Group: Dicot Class: Magnoliopsida – Dicotyledons Subclass: Asteridae Order: Scrophulariales Genus: Jasminum Species: Jasminum sambac (L. Sanskrit. Ayurvedic uses. Motia. Manipur BengaliBel/Beli. white. probably originated in India and was brought to Malaysia and Java around the 3rd century. Chazipur.Kaliyan. Volume 2(5):108-130 23 Jasminum dumicolum W. Anangam. Bondmalle. very little effort have been made to verify its efficacy through scientific screenings in animal model. Botanical / Scientific Classification (2. TeluguMallepuvvu. Iruvachi. Vernacular Names (2) ISSN: 2277-8713 IJPRBS Family: Oleaceae Tribe: Jasmineae. Moli.Mallika. Gauri. Bel. Mogra. Jazmine de Arsbia .Dundu Mallige.In Tamilnadu. Naga Hills. SpanishChamela. W. Jasminum sambac Linn. Mugra. Uriya – Belophulo. Hindi and MarathiMogra. Karmugai. Molli.) Ait. The present review highlights the various folk. very fragrant flowers cultivated nearly throughout the tropical and sub-tropical parts of the world2. Peramalli.sambac (Linn. broadly ovate or elliptic. Iruvadi. pharmacognostical. Mugra. Smith. Janeshta. Sikanderpur and Karnataka. MarathiMogara. Maladi. Devalata. opposite leaves. Ashtapadi. since then widely cultivated throughout the Malaysian region for its heavily scented flowers and tropics of both Hemispheres.com . Our thorough literature search revealed an interesting fact that though the plant is a popular remedy for a variety of ailments. Bondumalle. Boddumalle. are commercially cultivated for flowers (2.Melati . Gandhraja. 3) . phytochemical and pharmacological studies conducted on J. Ananga. Gundemalle. sambac and also highlight unexplored potential of it. Gamela. Azad. Urdu. 4) Taxon: Jasminum sambac (L. Raibel. Tamil. Virajadi.ijprbs. MalayalamCherupichakam.Review Article CODEN: IJPRNK Swati Sabharwal. Virajaji.) 111 Available Online at www.) Aiton World Wide Distribution J.Mallikaipu. Malle. TuluMa lligedai . Kannad. com . internode length.It is with single flowers. 3. number of whorls of petals and their size and shape. 2. but marked difference were observed in the length of style and stigma (1). Hazara bela 4. Bela 3.8-11. Volume 2(5):108-130 J. rounded petals and globular buds. sambac on the basis of shape of flower bud.26. 3.Motiya bela ISSN: 2277-8713 IJPRBS (4) 2. variable in shape. 4.Review Article CODEN: IJPRNK Swati Sabharwal. obtuse or acuminate. broadly ovate or elliptic. petal shape and number of whorls are reported4. calyx. sambac is variable and includes a large number of cultivars bearing single. 1-3 m tall. Bela. Motiya bela. IJPRBS. double flowers with elongated or rounded petals. young branches pubescent. (1) (2) (3) Fig 1: 1. entire. membraneous.5 by 2. 112 Available Online at www.It is also with double flowers with elongated petals. The different varieties showed minor variations in habit. Hazara bela. 1. size.3 cm.It is with multi-whorled petals which are rounded and the buds measuring about one inch in diameter. 2013. Four distinct sub-varieties of J. acute. Mungra.This group is with double flowers.ijprbs. shape of leaf. Mungra Botanical Description It’s a suberect or scrambling shrub. size of open flower and in the number of stamen. Leaves are Opposite. 4). linear-subulate. ISSN: 2277-8713 IJPRBS long. diam. Flowers are ¾ to 1 inch across and are powerfully fragrant. and once a week during the flowering season. IJPRBS. ripe carpels 1-2. Plenty of water is required during the summer growing season but reduce watering in winter. hairy. Dosage recommended per application per unit-Cattle manure or compost. terminal cymes. It is native to India and widely cultivated in South China. In its cultivation.ijprbs. T. narrowly oblong. Amm. Flower 4. Volume 2(5):108-130 glabrous.5).3cm. Stem Fig 3 Whole Plant Fig 4. petioles 3-6mm long. pedicals 6mm long. teeth 5-9. rarely acute. hairy. Corolla tube 1. The soil should be saturated with moisture to the root zone for good growth. 610mm.Review Article CODEN: IJPRNK Swati Sabharwal. The first pruning is done in the year following planting and thereafter once a year. 2013.25cm either way in a square any time between June-December but it is preferable to plant in the evenings. The flowering of jasmine is not correlated with the amount of rainfall although the water status in the soil prior to 113 Available Online at www. base rounded or subcordate. Whole plant 2. Flowers are White. hairy.300 kg (3. Trichomes Upper epidermis Vascular bundles Collenchyma Lower epidermis Fig 2: 1. It Blooms from June to September but it can bloom all year long in the greenhouse. Sulphate. surrounded by the suberect calyx teeth (2. Regular watering is required for optimum growth. long. 6 mm. Resistant to full sun and reflected heat in phoenix. The bushes are pruned during December-January every year. The bushes are irrigated three days after planting. Corolla 10 feet (3m). It can be planted 1. long. bracts linear-subulate. Calyx 1-1.com .10 kg. subglobose. water is critical especially during the establishment period where rooting and rapid plant growth occurs.3 cm. black. main nerves 4-6 pairs. acute or obtuse in cultivation orbicular. very fragrant. lobes as long as tube. solitary. Enviromental conditions and cultivation Plant is propagated using medium-mature stems (8 to 10 inches long) by planting in perforated plastic bags filled with sandyloam soil and watered daily.S of Jasminum sambac leaf 3. usually in 3-flowered. ear and mouth. 9. Root Root material in combination with other drugs is applied as external poultice in Sprains and fractures (12). very good in toothache. Leaves It is used in Fever. acting as tonic to the brain. diseases of mouth. in headache as analgesic. pungent. 6. in cancers. lowering the blood glucose level (4. leprosy. in diseases of blood. 7. relaxation and tension3. indolent ulcers. conjunctivitis 114 Available Online at www. IJPRBS. diarrhea. suppurations. opthalmopathy and in Diabetes mellitus (2. Economic importance Flowers are used in making garland. and to strengthen vision (11). 2013. nervousness. Plant is used with opium for gangrenous ulcers of the gums (3). It is used as emmenagogue. plant is traditionally used for cooling. In vapour therapy Jasmine oil can be useful for addiction. 10). J. indolent ulcers. skin disorders. ulcers. Morphological variation of Jasminum sambac with particular reference to distinguishing characters of economic value to the flower trade has been studied. of flowers are annually used for the extraction of perfumed oils and 250md for the preparation of attar (4). ISSN: 2277-8713 IJPRBS and in wound healing (3. 8) . coughs. Roots are used with leaves in eye lotions (13) . cures “tridosha”.com . Aroma-therapists find the Jasmine flower antidepressant and relaxing herb which is said to help with dry or sensitive skin and tiredness. In ulceration or eruptions in the mucous membrane of mouth the leaves are recommended to be chewed (2). itching sensation. in religious offerings. exudes a balsam which is used for anointing the head in eye complaints. 8). and diarrhea (2). Volume 2(5):108-130 induction may influence the intensity of flowering. Decoction of dried flowers is used as eyewash during reddening and swelling pain in the eye. Leaves if boiled in oil. depression. in cases of insanity.ijprbs. skin disorders. Oil prepared with the juice of the leaves is poured in to the ear in otorrhoea. weakness of sight and affections of mouth 2. useful in diseases of the eye.1 The plant is much valued for its exquisitely fragrant flowers and it is estimated that nearly 400md.Review Article CODEN: IJPRNK Swati Sabharwal. allays fever. biliousness. Traditional Uses Plant parts used: whole plant In India. cough. extraction of perfume (otto) and in cosmetic industries. abdominal distention. purgative. abdominal distention. 3. cooling. Flowers The flower is bitter. sambac are commercially cultivated for flower and value added products like essential oils. The harvesting of flowers is done from 2nd year after planting and the commercial yields commence from third year onwards (5). bouquets. in treating gallstones. Juices from the leaves are applied to remove corns. These include sambacin. Mainly the Iridoid glycosides are present. isoquercetin (III). IJPRBS. galactorrhoea (2. Aroma therapists believe Jasmine oil can be useful as an antidepressant.Review Article CODEN: IJPRNK Swati Sabharwal. jasminoside. Flavonoids include quercetin (II). cleansing and soothing properties. and skin diseases such as leprosy. The secretion is sometime arrested in twenty-four hours. Ethnobotanical Uses •Flowers yield a yellow pigment used as substitute for saffron (13). glycosides.15 Secoiridoid glucoside.sambacolignoside along with oleoside 11-methyl ester. cephalalgia. Sambacoside A (I). prurities. iridane triol. Jasmine oil applied externally is used to soften and smooth the skin. sambac (L. iridane tetraol. •Digestion with vegetable oil to make oil tinctures or liniments. leprosy.) Ait. stomatopathy. and hesperidin (VII). Ornamental •A favourite floral offering and adornment for altars. various types of pain including painful menstruation. for cancer. kempferol (V) and luteolin (VI). •Flowers in bean oil or coconut oil for hair.16. flavonoids and terpenoids. and anxiety. Its reputation as an intoxicant is legendary. In addition. (Oleaceace) has led to the isolation of oleoside 7.ijprbs. Apart from that inhaling Jasmine scent increases β waves in the brain. heart disease. 2013. rutin (IV). Roots: yielded: oleanolic acid. Sambacolingoside. 115 Available Online at www. saponins.17 Oligomeric irridoids like molihuasides A is a dimeric irridoid glycoside and Molihuasides C-E is a trimeric irridoid glycoside18. pain. 11) . Miscellaneous uses Cosmetic •Infusion of flowers used as a face wash because of its fragrance. Edibility •Flowers used to make jasmine tea (3). 3. which are associated with increased states of alertness (14). though this generally requires two or even three days (2). jaslanceosides B. 8.7. sambacoside19. and are said to arrest the secretion of milk in the puerperal state in case of threatened abscess. hiccough. Asian and Indian folk practitioners recommend Jasmine for liver complaints. Jasminin. dysentery. opthalmopathy. Flowers act as lactifuge.com . var. trifoliatum Hort. facial or body use or as a perfume oil or perfume base. otopathy. insanity. and a variety of other ills. Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS dermatitis. For this purpose about two or three handfuls of the flowers are bruised and applied moistened to each breast and renewed once or twice a day. as a calming agent to soothe stress. Leaves of J.11-dimethyl ester. and as an aphrodisiac. vomiting. Phytochemical studies: Leaves: contain major phytoconstituents as alkaloids. triterpenoids. malvalic acid. lupeol (XIV). Olueropin (XXXIX). inositol (XII). the aroma precursor of linalool and farnesol give the flowery character and are the main compounds involved in the production of scented tea. Benzyl acetate. 8. linoleic.1pentanolide. nerol. linalyl acetate (XXIII). myrcene (XIX). jasmone. sambacoside A. 2vinylpyridine (XVII). kaempferol-3-o-(2. 21 . Jasminoside (XXXV). benzyl benzoate. d and dl-linalool. eugenol (XXVIII). methyl N-methylanthranilate. nerolidol and eugenol (14). Jasminol (XXXVI). benzyl benzoate. α-jasmolactone. linolenic. methylpalmitate and methyl linoleate (XXXIII). isophytol (XXVI). methyl anthranilate. benzyl alcohol and cisjasmone give the fruity aromatic jasmine qualities.25 Yellow-flower of some Jasminum spp. Jasminolactone (XXXVII) Multiforin (XXXVIII). stearic (X). cisjasmone. P-cresol (XL). betulinic. linalool. methyl benzoate (XXIX) . methyl dihydrojasmonate. friedelin (XIII). contains verbascoside but are absent from the white-flowered J. racemic (5-pent-2-enyl)-5. benzyl cyanide (XXX). sambacoside E. beta terpenol. phytol (XXV). ursolic (XI) and oleanolic acid. methyl anilate. farnesol (XXVII). sambac26. Flowers: contains 3-hexenol. six oligomeric irridoid glycosides have been isolated21. From the leaves and stem: isolated Jasminol (VIII) is characterised as lup-20-en28beta-ol.9-dihydrojasminin. ISSN: 2277-8713 IJPRBS benzoate. alpha-amyrin (XVI). linalool (XX). 3(2-phenylethyl 6-O-α-Lrhamnopyranosiyl-β-D-glucopyranoside (βrutinoside) are identified from the flowers24. alpha terpenol (XXII). benzyl-o-β-D(1-6)-β-Dxylopyranoxyl.β-D-glucopyranoside and its 6-O-malonate. geraniol (XLI). 1-áterpineol. betulin (XV). benzyl acetate (XXXI). palmitic (IX). flavanoids. vanillin (XXXII).Review Article CODEN: IJPRNK Swati Sabharwal. Volume 2(5):108-130 and β-daucosterol.6-di-o-α-Lrhamnopyranosyl)-β-D-galactopyranoside20. 23. linalyl acetate. 116 Available Online at www. 22. xylitol and sorbitol. molihuaoside D. C20-C30 hydrocarbons. indole (XVIII).ijprbs. 9deoxyjasminigenin (XXXIV)16. nerolidol (XXIV). Glycosidic aroma precursor like benzyl 6-Oβ-D xylopyranosyl-β-D-glucopyranoside (βprimeveroside). 2013. benzyl alcohol (XXIX). rutin. farnesol. Linalyl. geranyl linalool (XXI). IJPRBS. D.mannitol.6 di-o-α-Lrhamnopyranosyl)-β-D-galactopyranoside and quercetin-3-o-(2. cis-3-hexenylbenzoate. benzyl alcohol. Jasmine oil: Methyl jasmonate.com . indole. Volume 2(5):108-130 O ISSN: 2277-8713 IJPRBS COOMe O O OH O O OGlc OH COOMe OH O O C O COOMe OH O OGlc OH O OH O Quercitin (II) OGlc Quercitin Sambacoside (I) OH OH OH O O HO OH O OH OH O OH OH O O HO OH OH O O O OH Me OH OH OH isoquercitin(III) Isoquercitin OH OH Rutin (IV) OH OH OH OH OH O O OH OH O OH O Luteolin Luteolin (VI) Kaempferol (V) 117 Available Online at www.ijprbs. IJPRBS. 2013.Review Article CODEN: IJPRNK Swati Sabharwal.com . Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS OH OH OH O OMe OH O O CH 3 O O OH OH O OH Hesperidin Hesperidin (VII) O O OH Palmitic Palmticacid acid (IX) Jasminol (VIII) OH OH OH OH H OH H O OH OH H OH Ursolic acid (XI) Stearicacid acid (X) Stearic Ursolic acid Me Me OH OH OH Inositol (XII) Inositol Me Me H OH Me OH OH O Me Me Me Friedelin Fridelin (XIII) 118 Available Online at www. 2013.com .ijprbs.Review Article CODEN: IJPRNK Swati Sabharwal. IJPRBS. IJPRBS.com . 2013. Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS H H H H OH H OH OH H Lupeol Lupeol (IVX) Betulin (XV) Betulin H N N N H OH α amyrin (XVI) Amyrin 2.Review Article CODEN: IJPRNK Swati Sabharwal.Vinylpyridine (XVII) 2.Vinylpyridine CH 2 CH 2 N H Indole (XVIII) Indole CH3 OH CH 3 CH3 Myrcene Myrcene (XIX) CH3 OH CH3 Geranyl linalool Geranyl linalool (XXI) Linalool (XX) O O OH H Linalyl acetate (XXIII) Linalyl acetate 119 Available Online at www.ijprbs. com . Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS α Terpenol (XXII) H O OH Phytol Phytol (XXV) Nerolidol (XXIV) OH OH Isophytol (XXVI) Isophytol Farnesol Farnesol (XXVII) O OH OMe Methyl benzoate (XXIX) Methyl benzoate Benzylalcohol alcohol Benzyl (XXVIII) N O O OH Benzyl cyanide(XXX) Benzyl cyanide Benzyl acetate (XXXI) O O H OH O OMe 120 Available Online at www.Review Article CODEN: IJPRNK Swati Sabharwal.ijprbs. 2013. IJPRBS. 2013. Volume 2(5):108-130 Vannilin (XXXII) ISSN: 2277-8713 IJPRBS Methyl linoleate (XXXIII) O O O MeOOC COOH O H O O O O OGlu OH Deoxyjasmigenin (XXXIV) Jasminoside (XXXV) OH HO O O O O O CH 2OH H OGlc O HO Jasminol (XXXVI) H Jasminolactone (XXXVII) COOMe O O O COOMe O H O HO OH O Multiforin (XXXVIII) O OGlc Oleuropein (XXXIX) 121 Available Online at www.Review Article CODEN: IJPRNK Swati Sabharwal.com .ijprbs. IJPRBS. The uniseriate. It showed the presence of single layered epidermis composed of flat rectangular cells covered by thin cuticle while lower epidermis covered by thick cuticle.5% Alcohol soluble extractive Moisture content Crude fiber content Swelling index Foaming index Less than 32% 6.11% 15% 1 100 Analytical study: 122 Available Online at www. 4(27).Review Article CODEN: IJPRNK Swati Sabharwal. unicellular and multicellular covering trichomes were present in the upper and lower epidermis as shown in Fig.ijprbs. Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS CH 3 OH OH CH 3 CH3 para Cresol CH 3 Geraniol Geraniol (XLI) p cresol (XL) Microscopical Study In transverse section the leaf appeared dorsiventral in nature showing three layers. IJPRBS. The following standards for identity and purity are reported (27) Standards for identity and purity Quantitative Standrards Parameters Values Total ash 14% Water soluble ash 7% Acid insoluble ash 8.com . 2013. 65. in Malaysia. 0. light (366 nm) three fluorescent zones at Rf.com . 0.63 as shown in Fig.01) reduction of elevated blood glucose level. IJPRBS.40 and 0.3:1) shows under U.9 TLC of Aqueous extract of the drug on Silica gel 'G' plate using Acetic acid: Conc. 5: TLC (Aqueous Extract) Pharmacological Activities: Antitumour Activity Antidiabetic Activity Different extracts viz.V. Gram -ve bacteria. 123 Available Online at www. HCl: Water (3:0. Sixteen endophytic fungal isolates tested were also found to exhibit antitumor activity in the yeast cell-based assay test around the disk of 6 mm or more were defined as positive for biological activity (28). Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS TLC: TLC of ethanol extract of the drug on Silica gel 'G' plate using Acetic acid: Conc.o on blood glucose level for 21 days were evaluated in alloxan induced diabetic rats. p.Review Article CODEN: IJPRNK Swati Sabharwal. HCl: Water (3:0. 2013. 5 & 6(27) . The screening of antitumour activity and antimicrobial activity against Gram +ve bacteria. Aqueous extract showed significant (p<0. 0.3:1) shows under U.86 and 0. yeast and fungi was carried out on isopropanol extracts prepared from isolates of endophytic fungi isolated from Jasminum sambac (L.) Ait. 0. ethyl acetate and water extract of leaves of Jasminum sambac at a dose of 300mg/kg. 4: TLC (Ethanol Extract) Fig. Ethyl acetate extract was found to be less active as compared to aqueous extract at 300mg/kg dose level (7).ijprbs. light (366 nm) three fluorescent zones at Rf.9. Fig.V. ) Ait. fumigatus and Curvularia species are the most prevalent fungi causing nail infection in human beings. Study shows that flowers 124 Available Online at www. Aspergillus Niger. (Staphylococcus aureus. Antibacterial activity using ethanol extract of J. Antimicrobial activity using ethanol extract of Jasminum sambac Ait.) Ait was evaluated using disc diffusion method for the inhibition of fungal growth and spore formation. coli. Antifungal activity using methanol extract of Jasminum grandiflorum. Results provide a support for the use of this plant in traditional medicine and its further investigation (30). Alternaria sp. A. typhimurium and K. Bacillus subtilis and Bacillus cereus) Gram -ve bacteria (Escherichia coli. B. fumigates. Salmonella typhimurium. mirabilis. methicillin resistant Staphylococcus aureus (MRSA). flavus. flowers.Review Article CODEN: IJPRNK Swati Sabharwal. Cytotoxic activity using ethanol extract of dried leaves of Jasminum sambac (L. aureus and Gram -ve S. fruits and stem bark was evaluated against nine bacteria and four fungi using Agar diffusion assay and Minimum Inhibitory Concentration (MIC) determinations. sambac exhibited antibacterial ISSN: 2277-8713 IJPRBS activity against both Gram +ve S. Pseudomonas aeruginosa and Chromobacterium violaceum) filamentous fungi Aspergillus niger. Methanol extract of Jasminum grandiflorum and Jasminum sambac proved to be active against. IJPRBS. (Oleaceae) leaves. pneumoniae and fungi. S.Oleaceae) was evaluated. Ethanol extracts of the callus of J.) Ait plant was evaluated against the following 3 strains: Proteius mirabilis. their antipathogenic potential was checked by examining the antiquorum sensing activity of such extracts using Chromobacterium violaceum assays. In addition. Alternaria sp. as well as against Gram -ve E. Jasminum sambac (L.) Ait was tested against an array of Gram +ve. Staphylococcus al bus. and the yeasts Candida albicans and Candida glabrata( 31). A. used traditionally as anticancer agents was evaluated in vitro for their antiproliferative activity against Hep-2.ijprbs. MCF-7. Jasminum sambac (L. subtilis.) Aiton (Family . The crude ethanol extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LD50 = 50 g/ml and LC90 = 100 g/ml). 2013. aureus. Alternaria sp( 32). Jasminum sambac (flowers and leaves) extracts were very active (>15 mm inhibition zone) against Gram +ve methicillin resistant S.com . niger. Candida albicans and Candida glabrata and yeasts. Antimicrobial Activity Antimicrobial activity using ethanol extract of Jasminum sambac (L. and Salmonella typhii and was found to be active against all the tested strains (33). Aspergillus fumigatus. sambac (L. Volume 2(5):108-130 Ethanol extract of Jasminum sambac (L. Klebsiella pneumoniae. A. and Vero cell lines. typhi and P.) Ait. extract demonstrated significant antiproliferative activity against one or more of the cell lines (29). including the filamentous A. Antioxidant activity using essential oil and methanol extract of Jasminum sambac (L. Anti-herpes Simplex Viruses and Antiadenoviruses Activity Analgesic Activity Analgesic activity using dried leaves extract of Jasminum sambac (L.) Ait. coli strain (35).Review Article CODEN: IJPRNK Swati Sabharwal. including HSV-1 and HSV-2) and antiadenoviruses (ADV. The extract produced significant (P<0.ijprbs.) flower hydro distilled essential oil. Volume 2(5):108-130 and leaves extracts of Jasminum sambac exhibited almost good activity (10-15mm inhibition zone) against Gram +ve bacteria including the Methicillin resistant Staphylococcus aureus (MRSA) and Bacillus subtilis while a moderate activity was recorded against Gram -ve bacteria including Escherichia coli and Klebsiella pneumonia(34). IJPRBS. The results from the disc diffusion method showed that ethanol extract of Jasminum grandiflorum could inhibit the growth of Propionibacterium (38). ISSN: 2277-8713 IJPRBS writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg of body weight comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. Butylated hydroxytoluene (BHT) was used as positive control in both test systems. namely DPPH free radical scavenging and -carotenelinoleic acid assays. synthetic blends and six major individual components was evaluated against Escherichia coli (MTCC 433) strain. was evaluated against the etiologic agents of acne vulgaris using agar well diffusion and broth dilution methods. Result showed that cytotoxicity of essential oil on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines (37).com . Anti-Acne Activity Antibacterial activity of jasmine (Jasminum sambac L. In the βcarotene-linoleic acid system. Study proved the antibacterial activity and mechanism of action of jasminum sambac natural oil and its synthetic blends against E. 2013. oxidation was effectively inhibited by Jasminum sambac ( 36) . Ethanol flower extract of Jasminum sambac (L.) Ait. leaves was evaluated by two complementary test systems. Oleaceae) was evaluated towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines.) Aiton (Family . ADV-8 and ADV-11) activities of hot water (HW) extract of Jasminum sambac flowers was evaluated using XTT-based colorimetric 125 Available Online at www.. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation (30).Oleaceae) was evaluated.001) Anti-herpes simplex viruses (HSV. Antioxidant Activity Antiacne activity of essential oil of jasmine (Jasminum grandiflora L. including ADV-3. e. our results demonstrated the stimulating/activating effect of jasmine oil and provide evidence for its use in aromatherapy for the relief of depression and uplifting mood in humans (41). and skin temperature. the decrease was significantly greater with bromocriptine. can mimic these effects (43). Oleaceae) on humans was investigated. Jasmine flowers seem to be an effective and inexpensive method of suppressing puerperal lactation and can be used as an alternative in situations where cost and nonavailability restrict the use of bromocriptine (40). can be used as therapeutic agents to treat against various diseases caused by free radicals and other chemical agents (42). sambac (L.) Ait.) Ait. Results of this study suggests that the methanol extract of J. Volume 2(5):108-130 assay. Suppression of puerperal lactation Efficacy of jasmine flowers (Jasminum Sambac (L. flowers showed anti-lipid peroxidative effect which is similar to that of all standards. were recorded as indicators of the arousal level of the autonomic nervous system.) Ait. ISSN: 2277-8713 IJPRBS Anti-lipid peroxidation effect of methanol extract of J. IJPRBS.) applied to the breasts to suppress puerperal lactation was compared with bromocriptine. 2013. Vitamin E and Rutin was evaluated.com . breathing rate.. and (R)-(–)-linalool. R–R intervals and the POMS test were measured before and after inhalation of the odors for 5 min.05). the low intensity of jasmine tea odor has sedative effects on both autonomic nerve activity and mood states. Autonomic Nervous Stimulating Effect The effect of aromatherapy massage with jasmine oil (Jasminum sambac L. Antistress Activity Antilipidemic Activity The antistress activity of the methanol extract of Jasminum sambac (L. Vitamin C.Review Article CODEN: IJPRNK Swati Sabharwal. one of its components. sambac (L. using the standard antioxidants Butylated hydroxytoluene (BHT). blood oxygen saturation. i. sambac (L.ijprbs. In the POMS tests. Autonomic Nervous Sedative Effect The effects of the odor of jasmine tea on autonomic nerve activity and mood states in a total of 24 healthy volunteers. Results showed that the tested hot water extracts exhibited anti-HSV and antiADV activities at different magnitudes of potency (39). In conclusion. Both bromocriptine and jasmine flowers brought about a significant reduction in serum prolactin. Human autonomic parameters. The methanol extract of the J.) Ait. Thus. Both jasmine tea and lavender odors at perceived similar intensity caused significant decreases in heart rate and significant increases in spectral integrated values at high-frequency component in comparison with the control (P < 0. pulse rate. blood pressure.) Ait. leaves was studied against swimming stress 126 Available Online at www. these odors produced calm and vigorous mood states. Methanol extract of Jasminum sambac at a dose of 100 mg/kg and 200 mg/kg p. 2010. 9. The spasmolytic effect of Jasmine absolute was most likely to be mediated through cAMP. producing a stimulant effect in man and enhanced movement in animals (45). Available from: URL: http://floriculturetoday. J. 2009 [Cited 2010 Aug 24]. Delhi CSIR. 3.] Aiton) in the Philippines.html. Antistress activity of Jasminum sambac Linn. 1956: 145. 7. Volume 2(5):108-130 induced gastric ulceration in rats and swimming endurance test in mice. Ethnobotany: Jasminum sambac. 8. Sanchez F C. Bhagat A. Publications and Information Directorate. Glossary of Indian medicinal plants. Raw Materials. Vol 7. Upaganlawar A B. 5. Oriental Enterprises 2003. IJPRBS. Nayar S L & Chopra I C.. A Dictionary of Raw Materials and Industrial Products. 16/2: 126 -36.com . which was used as standard. [online]. Floriculture: [online]. exhibited good antistress effect in both the tested models (44). 4. Kiritikar K R and Basu B D: Indian Medicinal Plants with Illustrations. leaves was compared with that of Geriforte (43mg/kg).ijprbs.in/fragrant-worldof-jasmine. Agro’s Dictionary of Medicinal Plants” Agrobios(India). ISSAAS. studied in vitro using a guinea-pig ileum smooth muscle preparation. Prajati N D & Kumar U. 289-290. 2003: 175-176. Anonymous. REFERENCES 1. 2nd 127 Available Online at www. Chopra R N. Ethnobotanical Leaflets 2009. Vol 5th: H-K. India. Santiago D & Khe C P: Production management practices of jasmine (Jasminum sambac [L. Available from: URL:ethnobotanyukmhoney. 2093-2096. 2013. Pharmacologyonline 2009: 1-6. The wealth of India. ISSN: 2277-8713 IJPRBS edition.o. Spasmolytic Activity Spasmolytic activity of Jasmine on guinea pig ileum (post synaptic and not atropinelike) and rat uterus was evaluated. 2009 [Cited 2010 Dec 24].com/ 2009_02_01_archive. Tenpe C R & Yeole P G: Effect of Jasminum Sambac leaves extracts on serum glucose and lipid profile rats treated with alloxan. and not through cGMP. 13: 1-32.html. New Delhi. 2. The mechanism of action of the spasmolytic activity. where it has a strong psychological input. was postsynaptic and not atropine-like.Review Article CODEN: IJPRNK Swati Sabharwal. The contradictory effect in vitro and in vivo has been suggested probably due to the solely physiological effects of jasmine absolute in vitro (producing a relaxation) compared with that in vivo. Chopda M Z & Mahajan R T: Wound healing plants of Jalgaon district of Maharashtra state. 6.blogspot. Luo S: Glycosidic aroma precursors of 2-phenylethyl and benzyl alcohols from Jasminum sambac flowers. Vol-4: j-q. Shen Y C. edition 2nd . Ina K. Phytochemistry 1995. 14. Raw Materials. C D R I. Publications and Information Directorate. 2006: 302. Yunnan Zhiwu Yanjiu 2004. Asiatic Publishing House. Watanabe N. Biotech & Biochemistry 1995. 12. 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Radu S & Kqueen C Y: Priliminary screening of endophytic fungi from medicinal plants in Malaysia for antimicrobial and antitumour activity. International Journal of Pharma Tech Research 2010. International journal of Pharmacy and Pharmcuetical Sciences 2011. 129 Available Online at www. IJPRBS. 9/2: 23-33. Liang L. isolated from foot infections in cancer patients. Phytochemistry 1994. Yu H. Abdoul-Latif F. Jensena S R. Journal of Pharm Sci 2011. Phytochemistry 2002. 34. Ina K & Luo S: Linalyl glucopyranoside and its 6-0-malonate as aroma precursors from Jasminum sambac. physico and phytochemical evalution of the leaves of jasminum sambac linn. Pharmacologyonline 2009. 70/2: 238-241. 2/2: 11651170. 36. Ethnobotanical Leaflets 2008. Mohamed N. 32. Watanabe N. Talib W H & Mahasneh A M: Antiproliferative activity of plant extracts used against cancer in traditional medicines. 29. 27. Joy P & Raja D P: Antibacterial study of Jasminum grandiflorum and Jasminum sambac. Swati sabharwal. 35. 26. 60: 213–231. 4/3: 38-43. Dash S K & Mishra R K: Antibacterial potential assessment of Jasmine essential oil against E Coli. Zu Y. Rath C C. Inagaki J. 36/6: 1435-1439. 28. Hussaini R A & Mahasneh A M: Microbial growth and quorum sensing ISSN: 2277-8713 IJPRBS antagonist activities of herbal plants extracts. Hasan S. Volume 2(5):108-130 25.Review Article CODEN: IJPRNK Swati Sabharwal. Indian Journal of Pharm sci 2008. African Journal of Plant Science 2010. Pharmacologyonline 2011. & Wu N: Activities of ten essential oils towards propionibacterium acnes and PC-3. Ali A & Djama A: Antimicrobial and antioxidant activities of essential oil and methanol extract of Jasminum sambac from Djibouti. 33. 31. 14: 3425-3435. (oleaceae). 15: 200-3210. ) Ait. 28/1: 68-71.ijprbs.Review Article CODEN: IJPRNK Swati Sabharwal. Chiang L C. [cited 2010 Sep 15] Available from: URL: http://hdl. Ito Y. Volume 2(5):108-130 ISSN: 2277-8713 IJPRBS 38. one of its major odor components. 42. Jasper M P. on autonomic nerve activity and mood states. Inoue N. Pharmacologyonline 2011. 2013. Europeon Journal of Applied Physiology 2005. 44. Hongratanaworakit T: Stimulating effect of aromatherapy massage with Jasmine Oil. 16: 437–39. 40. 130 Available Online at www. Shrivastav P. Hart S & Lo WH: Jasmine absolute and its mode of action on guineapig ileum in vitro. 95: 107–14. 26/11: 1600-1604. IJPRBS. Baby & Aimy A.com . Cheng H Y. 43. Babu S S & Suresh K: Antimicrobial properties of selected Indian medicinal plants against acne-inducing bacteria. Biological & Pharmceutical Bulletein 2003. 45. Thomas M. Kalaiselvi M & Kalaivani K P L: Phytochemical analysis and antilipid peroxidative effect of Jasminum sambac (L. 39. Pharmacological investigations of antistress Activity of jasminum sambac (linn) leaves. Kuroda K. 5/1: 157-62. George K. 14: 84-94. Liu M C. Lis-Balchin M. Natural Product Communications 2010. Australian & Newzeland Journal Obstetrics & Gynaecology 1988. Ethno botanical Leaflets 2010. Phytotherpy Research 2002. Kubota K & Sugimoto A: Sedative effects of the jasmine tea odor and (R)-(−)-linalool. & Kanagasabhapathy A S: Suppression of puerperal lactation using Jasmine flowers (Jasminum Sambac).handle. Oleaceae.net/123456789/928. Balasubramaniam N. [Online]. 41. Harisaranraj R. Chiang W & Lin C: In vitro anti-herpes simplex viruses and anti-adenoviruses activity of twelve traditionally used medicinal plants in Taiwan. 1: 38-43.