HIFU From HAIFU Clinical Application

March 23, 2018 | Author: Mehaboob Rahman | Category: Medical Imaging, Neoplasms, Cancer, Clinical Medicine, Public Health


Comments



Description

HIGH INTENSITY FOCUSEDULTRASOUND CLINICAL APPLICATIONS OBJECTIVE To study about the possible clinical applications which can be performed on the unit. ABSTRACT: High intensity focused ultrasound (HIFU,) is a medical procedure that applies high intensity focused ultrasound energy to locally heat and destroy diseased or damaged tissue through ablation. HIFU is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available. HIFU is a hyperthermia therapy, a class of clinical therapies that use temperature to treat diseases. HIFU is also one modality of therapeutic ultrasound, involving minimally-invasive or non-invasive methods to direct acoustic energy into the body. In addition to HIFU, other modalities include ultrasound-assisted drug delivery, ultrasound hemostasis, ultrasound lithotripsy, and ultrasound-assisted thrombolysis.Clinical HIFU procedures are typically performed in conjunction with an imaging procedure to enable treatment planning and targeting before applying a therapeutic or ablative levels of ultrasound energy. When Magnetic Resonance Imaging (MRI) is used for guidance, the technique is sometimes called Magnetic Resonance guided Focused Ultrasound, often shortened to MRgFUS or MRgHIFU. Currently, HIFU is an approved therapeutic procedure to treat uterine fibroids in Asia, Australia, Canada, Europe, Israel and the United States. HIFU is approved for use in Bulgaria, China, Hong Kong, Germany, Italy, Japan, Korea, Malaysia, Mexico, Poland, Russia, Romania, Spain and the United Kingdom. Research for other indications is actively underway, including clinical trials evaluating the effectiveness of HIFU for the treatment of cancers of the brain, breast, liver, bone, prostate, as well as soft tissue tumors. Non-image guided HIFU devices intraductal spread. For patients who cannot undergo operation. however. All the 13 patients received HIFU treatment safely. We hypothesized that HIFU could be a potential choice of treatment for breast cancer in the future. chemotherapy and radiotherapy can be alternative choices. After HIFU. Thus. [31] performed HIFU treatment in 12 patients with advanced stage renal cell carcinoma and one patient with colon cancer metastasized to kidney. HIFU ablation for renal cancer Renal cancer may also be treated with this noninvasive approach. Further investigations continue to study the efficacy of HIFU treatment of renal cell carcinoma for either cure or palliation. No side effects occurred after ablation using an experimental handheld device. surgery provides the best results. microwave coagulation. At present. Radiofrequency ablation (RFA). only less than 20% of patients are suitable for surgery when the diagnosis is made. HIFU ablation for pancreatic cancer Pancreatic cancer is among the eight most common cancers. HIFU ablation for breast cancer Breast cancer is the most common cancer in women and a leading cause of mortality. percutaneous ethanol injection (PEI). using these techniques remains difficult in treating tumors at problematic locations or advanced stages. However. including ten who had partial ablation and three who had complete tumor ablation.may be marketed for cosmetic purposes (typically for body fat reduction) in some jurisdictions. and laser-induced interstitial thermotherapy also offer potential local tumor control and occasionally achieve long-term disease-free survival. CLINICAL APPLICATIONS OF HIFU HIFU ablation for liver cancer Liver cancer is a comparatively frequent life-threatening malignancy. location. . we attempted to find alternative treatment for these patients. and the flank pain of presumed malignant origin disappeared in nine of ten patients. Wu et al. and risk of recurrence. cryoablation. offering a chance of cure by complete tumor removal. hematuria disappeared in seven of eight patients. but the role in local tumor control is limited. Surgery is the current standard of care in selected cases. A variety of treatments may currently be used depending on tumor size. respectively [33].4% and 46. this operation is unsuitable for patients wishing to remain fertile. Hysterectomy is the definitive treatment for uterine fibroids.HIFU ablation for uterine fibroids Uterine fibroid tumors (or leiomyomas) are the most common benign tumors in the female genital tract. However. HIFU is a potential treatment of choice for benign tumors. and these surgical procedures are associated with morbidity in about 17% to 23% of cases [34]. since such benign tumors cannot recur after total uterus removal. but cumulative uterine fibroid recurrence rates of 12 and 24 months after abdominal myomectomy were 12. Other applications HIFU has been used successfully for the treatment of soft tissue sarcoma in China [5]. The cyclic pain disappeared in all patients during a mean follow-up of 18. pain. . Myomectomy can be performed on patients who wish to retain their uterus.7 months HIFU from HAIFU Haifu® Model JC Extracorporeal ultrasound ablation treatment of tumors The System has been proved to be safe and effective for therapy of Malignant and benign tumors in a large number of patients.0%. The frequency of uterine fibroids is different across races and generally reported as 20% to 40% among reproductive age women [32]. because these tumors do not require complete excision. It has been used as an organ preserving treatment in patients with uterine adenomyosis [37]. As a noninvasive technique. they may lead to heavy bleeding. Depending on their location and size. and miscarriage. The requirement for further surgery is high. INDICATIONS Malignant tumors: • • • • • • • Liver Kidney Breast Pancreas Bone Soft Tissue Metastatic cancers Benign tumors: • Uterine Fibroids • Uterine adenomyosis • Breast Fibroadenoma ADVANTAGES  One time treatment  Non-invasive treatment  Real-time US-guided Procedure  Low cost  Short hospital stay  Minor complications  Not limited by tumor size .  No radioactive pollution or injury APPROVALS  Europe: CE  China: SFDA  Korea: KFDA  Russian Federation approval . evident reduction of fibroids .Haifu® Model JC200 Focused Ultrasound Tumor Therapeutic System Non-invasive Treatment of Uterine Fibroids CE-marked Ultrasound Therapeutic System INDICATIONS: Uterine Fibroids Uterine adenomyosis FEATURES Outpatient basis with quick recovery Only conscious sedation. no anesthesia required No surgical cut. no bleeding or blood transfusion Immediate coagulation necrosis of fibroids Great alleviation of symptoms. ADVANTAGES One time treatment Real-time US-guided Procedure Low cost No hospital stay No radioactive pollution or injury APPROVALS Europe: CE China: SFDA Korea: KFDA . SeapopinnaTM Model CZB Ultrasound Therapeutic Device for Rhinitis INDICATION Allergic Rhinitis FEATURES Non-invasive Treatment: No surgical wound. ADVANTAGES Safe: protecting and maintaining the structure of nasal cavity and nasal mucosa without any nose bleed. no additional harm. Repeatable: flexible clinical protocol for individuals.000 patient records. Convenient Data Management: Capacity of 40. adhesion of nasal cavity. mycteroxerosis or postnasal drip. User-friendly: 5-10mins treatment. . no nasal packing. easy to command. Environment-friendly: no radioactive pollution or smog. Patient-friendly Treatment: An outpatient procedure. no foreign object implanting. SeapostarTM Model CZF Ultrasound Therapeutic Device Non-invasive Treatment for Gynaecological Diseases     INDICATIONS Non-neoplastic epithelial disorders of vulva. Chronic cervicitis: Cervical ectopy (cervical erosion) Cervical cysts Cervical hypertrophy Vulval condyloma acuminatum . . conclude that ultrasound-guided HIFU ablation can achieve substantial tumor responses with only minimal and transient adverse effects. HIFU seems to be emerging as a safe. and feasible modality for the destruction of both benign and malignant solid tumors.FEATURES Non-invasive Treatment: Protecting and maintaining physiological functions and biological structure of cervix Safe Treatment: No post-treatment decrustation or scars Patient-friendly Treatment: out-patient procedure ADVANTAGES Low recurrence rate Quick recovery Low cost No smog or ionizing radiation Conclusions These results from different groups are consistently encouraging. Based on the results from clinical trials and studies. effective. Thus.
Copyright © 2024 DOKUMEN.SITE Inc.