Glucosamina e Condroitina Msm

March 18, 2018 | Author: juliosantanaXIV | Category: Dimethyl Sulfoxide, Osteoarthritis, Wellness, Medicine, Health Treatment
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13/05/13https://www.consumerlab.com/results/print.asp?reviewid=jointsupplements Printed version of www.consumerlab.com/review/Review_Glucosamine_Chondroitin_MSM_Supplements/jointsupplements/ Product Review: Glucosamine, Chondroitin, and MSM Supplements for Joint Health Initial Posting: 5/5/12 Updated 5/8/12 What It Is What It Does Quality Concerns and What CL Tested For What CL Found Test Results by Product What to Consider When Buying and Using Concerns and Cautions Full list of Ingredients by Product How Products Were Evaluated Update: Joint Juice Glucosamine-Chondroitin Blueberry Acai: (5/8/12) Upon original publication of this Review, this product was incorrectly classified by ConsumerLab.com as Not Approved for not including a warning for people with phenylketonuria. While such a warning is required for the artificial sweetener aspartame, it is not required for acesulfame K, the artificial sweetener in this product. ConsumerLab.com appreciates this error being brought to its attention on 5/8/12 by the distributor of the product, Joint Juice, Inc. The product has been reclassified as Approved, having met all quality criteria of this Review. What It Is: Glucosamine, chondroitin sulfate, and MSM (methylsulfonylmethane) occur naturally in the body. The glucosamine used in supplements is typically derived from the shells of shrimp or crabs although a corn source is also available. Glucosamine is available in a variety of chemical forms, such as glucosamine hydrochloride and glucosamine sulfate. These vary in terms of the amount of actual glucosamine available for use in the body from an equal weight of each form (See ConsumerTips™ for Glucosamine for more information). Chondroitin sulfate is generally derived from pig or cow cartilage, but even shark and chicken cartilage has been used. Chondroitin-like mucopolysaccharides from algae are also available. MSM is synthetically produced. What It Does: Glucosamine and Chondroitin: Glucosamine and chondroitin sulfate supplements are used to slow the progression of osteoarthritis — the deterioration of cartilage between joint bones — and to reduce the associated pain. A study sponsored by the National Institutes of Health (NIH) called the Glucosamine/Chondroitin Arthritis Intervention Trial (or GAIT study), showed that the combination of glucosamine and chondroitin sulfate seems to be effective in osteoarthritis patients with moderate to severe knee pain, although not those with mild pain. A well-controlled study of glucosamine sulfate (1,500 mg per day) versus placebo for lower back pain caused by osteoarthritis showed that both glucosamine and placebo improved symptoms reported by patients. However, there was no significant difference in the level of improvement between the groups, suggesting that glucosamine is not truly effective for lower back pain (Wilkens, JAMA 2010). A 2007 review of several past, large-scale studies of chondroitin alone concluded that it did not provide a benefit. However, a six-month study of chondroitin sulfate (800 mg once daily) versus placebo in patients with hand osteoarthritis showed a significantly greater decrease in hand pain and improvement in hand function among those taking chondroitin sulfate (Gabay, Arth & Rheum 2011). The duration of morning stiffness was also slightly reduced. These benefits were not noticeable until after 3 months of treatment. There was no significant difference in grip strength or the amount of analgesic used by patients. The chondroitin tested in the study was a tablet containing highly purified (95% pure) chondroitin of fish origin and is marketed as Chondrosulf (IBSA, Switzerland) in Europe where it is approved as a “Symptomatic Slow Acting Drug for Osteoarthritis” (IBSA website – accessed 9/21/2011). Glucosamine is thought to promote the formation and repair of cartilage. Chondroitin is believed to promote water retention and elasticity in cartilage and inhibit enzymes that break down cartilage. In veterinary medicine, glucosamine and chondroitin, often in combination, are commonly used in the treatment of degenerative joint disease — typically in older dogs and cats as well as in horses. (See separate review of Joint Health Supplements for Dogs, Cats, and Horses. MSM: MSM is used primarily for treating pain associated with osteoarthritis and has been proposed for treating other conditions including rheumatoid arthritis, inflammation of the bladder wall (interstitial cystitis), snoring, muscle spasm, and cancer. All of these uses for MSM, including those for arthritis, are based on limited research, so its effectiveness hasn't been well established. Many additional claims are found on MSM products, including skin-softening and https://www.consumerlab.com/results/print.asp?reviewid=jointsupplements 1/11 DMSO is a chemical solvent.asp?reviewid=jointsupplements 2/11 . which can then be used to synthesize certain amino acids (building blocks for proteins). Why do some chondroitin products contain less chondroitin than claimed? Some manufacturers may rely on non-specific tests. in which products undergo the same testing. TR CAPS TR Joint Plus Caps was found to contain only 71. lead accumulates in the body (in bones) and. but a likely source is the crab shells from which glucosamine is made. These tests can easily be tricked by other compounds that are not chondroitin. may be avoided by choosing a product made from the cartilage of other animals. such as turmeric (or curcumin) and boswellia. As a veterinary medicine. see the article on Osteoarthritis on this website. Children are particularly sensitive to lead and should not be exposed to more than 6 mcg in total per day. If you just want glucosamine . as a result.com/results/print. KAL Glucosamine Chondroitin MSM was also contaminated with lead. While toxicity is not likely in adults from using from this product. but among the 21 products claiming to contain glucosamine and/or chondroitin. A manufacturer looking to cut corners might buy lower cost material "certified" with a non-specific test and. MSM: MSM is chemically related to DMSO (dimethyl sulfoxide). MSM products were additionally tested for DMSO contamination. This far exceeds the 0. What CL Found: Among the 22 supplements ConsumerLab. so its effectiveness hasn't been well established. end up making products with no or little real chondroitin. Some manufacturers have advocated a limit of 10 mcg per daily serving. The mechanism by which MSM may work isn't well understood. There have not been any reported cases of the disease from chondroitin and the risk seems to be miniscule because the prion thought to be the causative agent of the disease exists only in very low levels in cartilage. -.com’s review due to lead contamination. but none of these are well supported by research. Cost comparisons The cost of supplements for joint health vary considerably – and paying more doesn’t necessarily mean you are getting a better product. ConsumerLab. was. on the other hand. less ingredient than labeled. chickens. All products were also tested for lead contamination. such as the "CPC (cetyl pyridinium chloride) titration method" or “size-exclusion chromatography method” when evaluating chondroitin. For more information about the clinical evidence for these and other supplement ingredients. however.com selected and tested. the least expensive supplement. A potential downside to the Puritan’s Pride product. It still has limited use. re-testing was performed in a second independent laboratory for confirmation (see How Products Were Evaluated).2 micrograms of lead per daily serving. However. however. the manufacturer sets its own limit based on what is considers acceptable. MSM is used to treat muscle and tendon soreness and inflammation in horses -. Real chondroitin is relatively expensive. can adversely affect the nervous system and increase blood pressure. No problems were found with the MSM content of the selected products (and none contained an unacceptable level of DMSO). Through ConsumerLab. Other products with glucosamine (without chondroitin or MSM) were much more expensive (over $1 per day). is that it is a single daily pill while most clinical trials have divided the dose into more than one pill per day. Minerals and botanical ingredients also have the potential for lead contamination. Because no government agency is responsible for routinely testing glucosamine. The Supplement Facts panel was also not properly written: listing a daily serving of two caplets but showing the amount of glucosamine in only one caplet.S. Chondroitin. by far. ConsumerLab. chondroitin.consumerlab. The issue of BSE.asp?reviewid=jointsupplements on limited research. An ingredient supplier might sell lower priced "chondroitin" to which compounds have been added to fool these tests. however. DMSO in products indicates poor-quality manufacturing. Maximum Strength DONA Crystalline Glucosamine Sulfate contained its claimed amount of glucosamine but its label lacked a required shellfish allergen warning statement (as glucosamine is made from crab shell and some people may be allergic) and the product included an ingredient (Eudragit RL) which has not been approved for use in supplements in the U. All tablet and caplet products were found to properly break apart in solution (disintegrate). Many additional claims are found on MSM products.7 micrograms of lead per daily serving. which has been used in ways similar to MSM.13/05/13 https://www. Although not thought to be a health risk in small amounts. It was found to contain 1. Every supplement manufacturer is required to test their ingredients or finished product for lead contamination. The Whole Foods products contained glucosamine.although it is approved for use in drugs." For each product that failed to contain its listed chondroitin. There had been concern with bovine (cow) sources of chondroitin several years ago on account of Mad Cow disease (known scientifically as bovine spongiform encephalitis or BSE). although at a lower level than the Whole Foods product. as well as calcium (330 mg/day) and an unlisted amount of peppermint leaf. ConsumerLab. is an ingredient with which ConsumerLab. or sharks.com/results/print. Unlike MSM. DMSO was found to cause a range of adverse reactions and is no longer approved as a supplement. validated method known as the "enzymatic HPLC method.com independently evaluated several human and veterinary products to determine whether they contained the amounts of these ingredients stated on their labels.S. or failure to meet other FDA labeling requirements. all tablets and caplets (excluding chewable or time-release) were tested for their ability to properly disintegrate ("break-apart"). Puritan's Pride Premium Glucosamine HCL at 12 cents per day. however. an additional 20 products were found to meet quality standards. The reasons why products failed are described below and in the results table: Whole Foods Glucosamine and Chondroitin Complex was contaminated with 13. it's most abundant in nervous and glandular tissues. Also see ConsumerLab. at high levels. as SAMe can help treat osteoarthritis pain. Cats and Horses. and it can act as an antioxidant. only 18 met quality standards and FDA labeling requirements.com’s Voluntary Certification Program. which can be contaminated. See the ConsumerTips™ later in this report for insightful information on buying and using these supplements.see separate review of Joint Health Supplements for Dogs. and MSM supplements for their contents or quality. Quality Concerns and What CL Tested for: Glucosamine and Chondroitin: Although prior testing has shown the vast majority of glucosamine products to meet label claims.consumerlab.com’s Product Review of SAMe Supplements. under current law. although many of them include additional ingredients of some potential benefit. https://www. much higher than the State of California permits without a warning label. Why are some of these supplements contaminated with lead? It is hard to know for sure. although it is known to contribute sulfur to the body.5% of its claimed chondroitin.com evaluated chondroitin products using a more specific. Products sold in California that exceed this limit are required to carry a warning label regarding lead.com has protested against such a high level. glucosamine from shellfish such as shrimp and crabs may potentially be contaminated with lead. four products (19%) failed to pass ConsumerLab.com has found problems in the past — with products not always providing the amount claimed of this expensive ingredient. This product is apparently sold in Europe as well as the U. including skin-softening and nail-strengthening effects. for those under medical supervision.5 mcg limit set by the State of California (the only state to set a limit) which nearly all other products did not exceed. In addition. such as pigs (now a common source). 21st Century Glucosamine 750 Chondroitin 500 Triple Strength was the next least expensive (22 cents per day). The amounts of MSM in these products ranges. NOW Vegetarian Glucosamine & MSM. formulas. Additional notable ingredients are found in the last column. which turned out to provide a substantial amount of MSM (1.consumerlab.TEST RESULTS -OVERALL RESULTS: APPROVED (Passed) or NOT APPROVED (Failed) Met Claim Broke Apart Properly Free of Unacceptable Levels of Lead Cost Per Suggested Daily Serving (Unless Otherwise Noted)1 Additional Key Ingredients. they include within proprietary blends. This serving provides 1. Phosphatidylcholine.asp?reviewid=jointsupplements 3/11 . available from products such as GNC Triflex. Interestingly.500 mg of glucosamine and 1. Shown for each product are the claimed amounts of glucosamine.13/05/13 https://www. and/or Special Designations2 Price Paid Cost Per 1. and Horses is available. chondroitin. Cats. instead.) The other two products in this category cost $1. Note: Supplement required shellfish Dist. as noted earlier. by Healthy Directions Ingredients Maximum Strength DONA™ Crystalline Glucosamine Sulfate (2 caplets daily) 1. the least expensive product was. Ireland. To find retailers that sell some of the listed products click here. the reason is explained in red text.30 or more per daily serving.com/results/print. For example. extract. GNC Triflex Fast-Acting. as is a review of SAMe supplements. A separate review of Joint Health Supplements for Dogs. or Vitamin Shoppe® Joint Solutions Triple Strength Glucosamine & Chondroitin with MSM. While there may be value to some of these blends. if a product failed testing.200 mg of chondroitin (the combination most commonly recommended) was Simply Right Triple Strength Glucosamine and Chondroitin (sold at Sam’s Club) at a daily cost of 17 cents. Twenty were tested at the request of their manufacturers/distributors through CL's Voluntary Certification Program and are included for having passed testing. and MSM and the suggested daily serving on its label.500 mg Glucosamine Sulfate 2KCl NOT APPROVED $1. Some triple-combination products do not specify the amounts of chondroitin and MSM they contain.2 mg).consumerlab. at just 6 cents per 1.6 mg).200 mg of chondroitin is about 40 to 60 cents. ##TABLE_REVIEWS_LINK_ROWS_7## CONSUMERLAB. Also listed is one product similar to another that passed but is sold under a different brand name.08 Meriva (Turmeric. we checked Nutrilite Glucosamine-7’s blend. Conversely. or complexes. a daily serving of Nature’s Bounty Flexamin’s blend contained a little more chondroitin (234 mg per daily serving) but less MSM (132.COM RESULTS FOR JOINT HEALTH SUPPLEMENTS (GLUCOSAMINE.. The suggested 2 capsule serving costs 20 cents. Doctor’s Best Best MSM 1500 was the least expensive. the most expensive product didn’t even contain its listed amount of chondroitin: TR CAPS TR Joint Plus Caps 8 Hour Time-Release cost $2. (although approved in https://www.50 for the full 3 tablet daily serving but. Test Results by Product: Listed alphabetically within each product group below are test results for forty-two supplements of which ConsumerLab. If you are looking for both glucosamine and chondroitin. by Rottapharm Ltd.500 mg Glucosamine Sulfate 2KCl APPROVED $1.500 mg.500 mg of glucosamine. (Increasing the dose to 3 capsules per will provide the generally recommended dose of 1. chondroitin. but the highest amount (900 mg) is in GNC Triflex. eggshell membrane) $26. (Eudragit RL) not unapproved for use in supplements.com suggests purchasing products that specify how much they contain of each ingredient.16 $34.com/results/print.79/60 caplets Product missing Mfd. AND MSM) Click on beneath a product name to find a vendor that sells it.5% of its listed chondroitin. Also Ingredients mg).636 mg per daily serving) but not a lot of chondroitin (79. CHONDROITIN. and MSM – the lowest cost for a serving providing at least 1. To get glucosamine and MSM.99/150 tablets Glucosamine Only Products: Dr.asp?reviewid=jointsupplements while most clinical trials have divided the dose into more than one pill per day.500 mg of glucosamine and 1. ConsumerLab. Facts box shows allergen amount per caplet (750 statement. Jarrow Formulas Glucosamine + Chondroitin + MSM. Whenever possible. If you want all three of the reviewed ingredients – glucosamine. but should show contains an amount per daily ingredient serving. Product Notes. you won’t really know what you are getting. contained only 71.500 mg Glucosamine 1. David Williams Joint Advantage Gold® Advanced Relief (3 tablets twice daily)* Dist. Products that passed all tests are indicated as Approved in the third column. in USA by WynnPharm Inc. along with cost comparisons. the least expensive supplement providing 1.000 mg each of glucosamine and MSM. Among MSM products. by far.com selected twenty-two. Product Name and Suggested Daily Use Manufacturer or Distributor Click on "Ingredients" for Full Listing Claimed Amount and Form of Joint Health Ingredient Per Suggested Daily Serving on Label -. which are also used for treating osteoarthritis. 00/120 coated caplets Ingredients Shaklee® Joint Health Complex (2 coated caplets daily) Dist.500 mg Glucosamine HCl APPROVED $1. Boswellia serrata extract.com/results/print. by Puritan's Pride.com/results/print.000 to 3.000 mg APPROVED N/A Cost per 1. Inc. by US Nutrition. Inc. curcumin complex. and assorted minerals $44. by Doctor's Best.000 mg APPROVED 2.asp?reviewid=jointsupplements approved in drugs).200 mg Chondroitin $0.49 Gluten free and vegetarian USANA® Optimizers Procosa® (3 tablets daily)* Dist. $14.67 (Pack includes vitamin and mineral pills) Gluten free $49. by General Nutrition Corporation Ingredients 1.151 Gluten free $9.79/60 capsules $0. by Vitamin World.consumerlab. Inc.500 mg Glucosamine HCl APPROVED $0. Inc.500 mg MSM $0.00/90 capsules COMBINATION PRODUCTS https://www.500 mg APPROVED $1.99/30 packets Spring Valley® MSM 1000 mg (1 capsule two to three times daily)* Mfd. by CVS Pharmacy.80/60 tablets MSM Only Products: CVS® pharmacy MSM 1000 mg (1 capsule two to three times daily)* Dist. Inc.500 mg Glucosamine HCl APPROVED $1. Ingredients Similar to Approved Product:** 1.000 mg APPROVED N/A $0.consumerlab. Ingredients Chondroitin Only Products: Source Naturals® Chondroitin Sulfate (1 tablet one to three times daily) Dist. by Source Naturals. Inc. Ingredients 2.171 $6. by USANA Health Sciences.000 to 3.56/84 tablets Vitamin World® Triple Strength Glucosamine HCL 1500 mg Similar to: Puritan's Pride® Premium Glucosamine HCL 1500 mg (1 coated caplet daily) Mfd. Ingredients 1.12 Lowest cost glucosamine Gluten free Puritan's Pride® Premium Glucosamine HCL 1500 mg (1 coated caplet daily)* Mfd.500 to 3.62/120 tablets GNC TriFlex™ Complete Vitapak® MSM (1 caplet daily)* Dist.65/60 coated caplets 1. Ingredients 600 to 1. 1. Ingredients Doctor's BEST® Best MSM 1500 (1 tablet one or two times daily) Dist.421 Gluten free $12.061 Lowest cost MSM Vegetarian $6. by the Shaklee Corporation Ingredients Vitamin C.800 mg Chondroitin Sulfate APPROVED Cost Per 1.09 Vitamin C.asp?reviewid=jointsupplements 4/11 .13/05/13 https://www. and assorted minerals $30. Inc. 13/05/13 COMBINATION PRODUCTS https://www.44/200 coated tablets 1. Inc.39 to $1.asp?reviewid=jointsupplements Glucosamine and Chondroitin Combination Products: 21st Century® Glucosamine 750 Chondroitin 600 Triple Strength (1 to 2 tablets daily)* Dist. Ingredients Thorne Research® Glucosamine and Chondroitin (1 vegetarian capsule three times daily) Mfd. by The Elations Company Ingredients 1.500 mg APPROVED Chondroitin Glucosamine HCl https://www. once daily) Dist.25 to $0. Inc. by Natrol.36/120 tablets GNC Glucosamine 750 Chondroitin 600 (1 caplet one to two times daily)* Dist.50 Gluten free $29. Inc. Ingredients 500 to 1. by General Nutrition Corporation Ingredients 750 to 1. by Joint Juice.43 5/11 .com/results/print.500 mg Glucosamine HCl 400 to 1.65/90 vegetarian capsules Trader Joe's® Glucosamine 1.99/120 caplets Joint Juice® GlucosamineChondroitin Blueberry Acai (liquid. Ingredients 1.61 Gluten free Nexrutine® phellodendron extract $18.200 mg Chondroitin Sulfate APPROVED $0. by Nutramax Laboratories.consumerlab.500 mg Glucosamine HCl 600 to 1.200 mg Chondroitin Sulfate APPROVED $0. Inc.86 Calcium and boron $5.200 mg Chondroitin Sulfate APPROVED $0.com/results/print.20 $59.200 mg Chondroitin Sulfate APPROVED N/A $0. potassium and sodium $4. by 21st Century HealthCare.99/box of 7 (7 gram) packets FeelAnew® Glucosamine and Chondroitin with Nexrutine® (2 tablets twice daily) Mfd.74/300 tablets Cosamin® DS (1 to 3 tablets daily)* Dist.11 to $0.500 mg Glucosamine HCl 1. Ingredients Simply Right™ Triple Strength Glucosamine and Chondroitin (1 coated tablet twice daily) Dist.222 mg Glucosamine Sulfate 2KCl 668 mg Chondroitin Sulfate APPROVED $0. bottle Vitamins C and D.17 Lowest cost glucosamine/ chondroitin combination Gluten free $17. 1 bottle.200 mg Chondroitin Sulfate APPROVED $0. Ingredients 2.500 mg Glucosamine Sulfate 2 KCl 600 to 1.74 per 8 oz. Inc. Inc. by Thorne Research.asp?reviewid=jointsupplements N/A $0.500 mg Glucosamine HCl 1.99/150 tablets Elations® Healthier Joints Cranberry Apple (powder. 1 packet [7 grams] daily) Dist. 8 fl oz [237 mL].500 mg Glucosamine Sulfate 2KCl 750 mg Chondroitin Sulfate APPROVED N/A $0.22 $33. by Sam's West.500 mg Glucosamine HCl 200 mg Chondroitin Sulfate APPROVED N/A $0.42 per package of 6 bottles 1. Ingredients 750 to 1.96 $28.consumerlab. LLC Ingredients 2.asp?reviewid=jointsupplements Glucosamine HCl Gluten free 1. Inc.75 Calcium $24. Boswellia serrata extract.000 mg Glucosamine HCl 1.99/90 controlled release tablets 1.37 Niacin.2 micrograms of lead per daily serving $0.000 mg MSM $12. Boswellia serrata extract. 30 mL] once daily)* Dist.00/120 vegetable capsules Drinkables® Liquid Supplements Liquid Joint Care Natural Citrus Flavor (liquid.91 Gluten free Vitamin D.14/120 vegetarian capsules 1. by Trader Joe's Ingredients Twinlab® Joint Fuel® (3 capsules twice daily)* Mfd. ginger. by Nutri-Supreme® Research Ingredients 1. Inc.90/120 tablets Glucosamine.consumerlab.99/100 tablets Glucosamine and MSM Combination Products: Maxi-Health® Super Glucosamine Complex™ (3 capsules once daily) Dist.38 Vitamins C and E. and quercetin $27. Chondroitin. Inc.99/33 oz bottle Finest Natural® Glucosamine Chondroitin Double Strength (3 tablets daily)* 1.000 mg MSM APPROVED $1. zinc. selenium.30 Gluten free and k osher $77.200 mg Chondroitin Sulfate 500 mg MSM APPROVED N/A $0.500 mg Glucosamine Sulfate 2 KCl 250 mg Chondroitin Sulfate 500 mg MSM APPROVED N/A $1. by NOW FOODS Ingredients 1. by BioGenesis Nutraceuticals.com/results/print. rosemary. by Remington Health Products. and MSM Combination Products: BioGenesis® Nutraceuticals ArthroGenx (2 vegetable capsules twice daily) Mfd. proprietary blend of collagen and hyaluronic acid $29.200 mg Chondroitin Sulfate $12. 2 tablespoons [1 fl oz. by Maxi-Health® Research.90/180 capsules APPROVED N/A $0. vitamin C. blend of Chondroitin Sulfate and MSM https://www.000 mg Glucosamine HCl 1.20 Gluten free and vegetarian/vegan Nutri-Supreme® Research Ultra Joint Support with Glucosamine and OptiMSM™ (4 tablets once daily) Dist.500 mg Glucosamine Sulfate 2KCl 1. Ingredients NOW® Vegetarian Glucosamine & MSM (2 vegetarian capsules once daily) Mfd.500 mg Glucosamine Sulfate 2KCl 100 mg Chondroitin Sulfate APPROVED N/A $1. Ingredients 1.350 mg Proprietary Dist. by Walgreens Co.500 mg Glucosamine HCl APPROVED Glucosamine Chondroitin sulfate and $0. and turmeric extract $41. and assorted minerals 6/11 1. by ISI Brands.200 mg Chondroitin Sulfate NOT APPROVED Found 13.33 Kosher and vegetarian $39.asp?reviewid=jointsupplements .500 mg Glucosamine HCl 3.com/results/print. hyaluronic acid. by Whole Foods Market Ingredients 1. Ingredients https://www.13/05/13 Chondroitin (3 controlled release tablets daily) Dist.62 Proprietary blend of collagen.57/120 capsules Whole Foods® Glucosamine and Chondroitin Complex (1 tablet three times daily) Dist.500 mg Glucosamine Sulfate 2KCl 750 mg MSM APPROVED N/A $1. turmeric root extract.consumerlab. 500 mg MSM NOT APPROVED Found 1. by Nature Made Nutritional Products Ingredients 1.com/results/print.99/240 tablets GNC Triflex™ (3 caplets once daily)* Dist.49/60 coated tablets Nutrilite® glucosamine-7 1.consumerlab.500 mg Glucosamine Sulfate 2KCl 1.75/120 capsules KAL® Glucosamine Chondroitin MSM (3 tablets once daily) Mfd.43 Gluten free Vitamin C and manganese $12.62 Gluten free Vitamin D.13/05/13 Ingredients https://www.99/60 caplets Nature's Bounty® Flex-a-min® Triple Strength with Joint Flex™ (2 coated tablets once daily) Mfd.67 (Pack includes vitamin and mineral pills) Gluten free Vitamin C.500 mg APPROVED https://www.49/240 caplets GNC TriFlex™ Complete Vitapak® TriFlex™ Fast Acting (4 caplets once daily)* Dist.500 mg Glucosamine HCl 1.49/240 caplets Jarrow Formulas® Glucosamine + Chondroitin + MSM (4 capsules once daily) Dist.200 mg Chondroitin Sulfate 900 mg MSM APPROVED $0.asp?reviewid=jointsupplements Sulfate and MSM sulfate and complex MSM not tested3 minerals $49.consumerlab. and hyaluronic acid $33. Chinese skullcap root extract.56 Gluten free Vitamin C.99/30 packets GNC Triflex™ Fast-Acting (4 caplets once daily)* Dist. proprietary blend of collagen.210 mg Proprietary blend of Chondroitin Sulfate and MSM APPROVED Glucosamine Found 132.7 micrograms of lead per daily serving $0.500 mg Chondroitin Sulfate 300 mg MSM APPROVED N/A $0. silica.500 mg Glucosamine HCl 1. citrus bioflavonoids.asp?reviewid=jointsupplements $1. by Nutraceutical Corp. and hyaluronic acid $49.41 Gluten free Vitamin C and hyaluronic acid $32. Ingredients 1.200 mg Chondroitin Sulfate 250 mg MSM APPROVED $0.84/90 tablets Nature Made® Triple Flex (2 caplets once daily)* Dist.com/results/print.500 mg Glucosamine HCl 1. by General Nutrition Corporation Ingredients 1. Chinese skullcap root extract.05 7/11 . by General Nutrition Corporation Ingredients 1. by Jarrow Formulas® Ingredients 2. by Arthritis Research Corp. Ingredients 1. proprietary blend of Cutch tree wood and bark extract.83 Gluten free $24.500 mg Glucosamine HCl 1.200 mg Chondroitin Sulfate 250 mg MSM APPROVED $1. proprietary blend of Cutch tree wood and bark extract.200 mg Chondroitin Sulfate 1.500 mg Glucosamine HCl 800 mg Chondroitin Sulfate 750 mg MSM APPROVED $0. by General Nutrition Corporation Ingredients 1.1 mg MSM per tablet $0. and hyaluronic acid $18. Boswellia serrata extract.0 mg chondroitin sulfate per tablet Found 66.59 Vitamin C $17.000 mg Glucosamine Sulfate 2 KCl 1. 500 mg APPROVED Glucosamine Sulfate Glucosamine 1. sarsaparilla root. and an herbal blend (alfalfa leaf. manganese amino acid chelate.67 to $1. by Rexall Sundown.92/75 coated caplets Schiff® Move Free® Advanced -Triple Strength. by TR Caps Ingredients 500 to 1. celery seed) $16.99/60 capsules Trace Minerals Research® ActivJoint™ Platinum (2 to 6 tablets.05 Vitamin C. Ingredients 1. red clover herb. capsicum fruit. once daily) Dist.consumerlab.09 Gluten free B vitamins. 2 tablespoons [1 oz. Ingredients 1.200 mg Chondroitin Sulfate 1.13/05/13 Nutrilite® glucosamine-7 (2 tablets twice daily) Dist.500 mg MSM APPROVED N/A $1.200 mg Glucosamine Sulfate 2KCl and HCl 200 to 600 mg Chondroitin Sulfate 266.35 Vitamin D.99/80 coated tablets TR CAPS TR Joint Plus Caps 8 Hour Time-Release (1 time release capsule. by Access Business Group International LLC Ingredients https://www. proprietary blend of Chinese Skullcap and Black Catechu.24 $29. Boswellia serrata extract. Inc. Ingredients 1. one to three times daily) Dist. by The Vitamin Shoppe® Ingredients 1.99/120 tablets webber naturals® Glucosamine Chondroitin MSM (5 capsule.34/90 tablets Vitamin Shoppe® Joint Solutions Triple Strength Glucosamine & Chondroitin with MSM (1 tablet twice daily)* Dist. Plus MSM & Vitamin D3 (2 coated tablets once or twice daily) Mfd. hydrangea root.000 mg APPROVED Glucosamine® Natural Berry Glucosamine HCl Flavor (liquid. assorted minerals. 30 1. and hyaluronic acid.250 mg Proprietary blend of Chondroitin Sulfate and MSM APPROVED Glucosamine Chondroitin sulfate and MSM not tested3 $0.67 to 800 mg MSM $0. by Trace Minerals Research Ingredients 400 to 1. devil's claw tuber.com/results/print.74/120 capsules Wellesse™ Joint Movement 2.5% of claimed chondroitin sulfate APPROVED N/A $0.9 mg chondroitin sulfate per tablet Found 409 mg MSM per tablet $1. and citrus bioflavonoids $13. by Schiff Nutrition Group. horsetail herb.60/120 tablets Osteo Bi-Flex® Advanced (2 coated caplets daily)* Mfd.asp?reviewid=jointsupplements 1.780 mg Proprietary blend of MSM and Chondroitin Sulfate Found 19. vitamin C.500 mg Glucosamine Sulfate 2 KCl 1. and assorted minerals $25.consumerlab.36 to $1.50 $49.200 mg Chondroitin Sulfate 100 to 300 mg MSM NOT APPROVED Glucosamine and MSM Found only 71.500 mg Glucosamine Sulfate 2KCl 1.200 mg Chondroitin https://www.com/results/print. burdock root.58 $34. proprietary blend of boron.000 mg Glucosamine HCl 200 to 400 mg Chondroitin Sulfate 750 to 1.200 mg Chondroitin Sulfate 500 mg MSM APPROVED $0.asp?reviewid=jointsupplements N/A $1.69 Proprietary blend of collagen. acerola concentrate.12 Vitamin D 8/11 . Inc.500 mg MSM APPROVED $0.500 mg Glucosamine HCl 1. yucca root. and hyaluronic acid $26.83 to $2.500 mg Glucosamine Sulfate 2 KCl 400 to 1. Boswellia serrata extract. once daily)* Dist.500 to 3. by WN Pharmaceuticals® Ltd. The GAIT study sponsored by the NIH used chondroitin sulfate made by Bioberica which is believed to be 95% pure. For each product. Prices may vary by retailer and number of pills per package.200 mg of chondroitin sulfate is recommended per day. CL cannot assure the accuracy of information provided to it by third parties. To reduce your sodium intake. cost for Chondroitin-Only based on 1. 2 tablespoons [1 oz.asp?reviewid=jointsupplements 1. chondroitin sulfate. Cost for Glucosamine-Only products based on 1. ConsumerTips™: What to Consider When Buying and Using: Glucosamine & Chondroitin: Glucosamine in supplements can be purchased in different chemical forms. With that form you'll add about 191 mg of calcium per day to your diet instead of sodium.com LLC. In fact. Some products mention in their labeling that they contain chondroitin A which is a subcomponent of the larger chondroitin polysaccharide.asp?reviewid=jointsupplements 9/11 . but some products do not make this adjustment.500 mg per day of either form appears to be effective. 30 mL]. only 938 mg or 888 mg of free glucosamine. For example. non-enteric coated.200 mg serving.500 mg serving." These are the complete chemical names — although not all manufacturers use them — and the active ingredient.500 mg of glucosamine sulfate with 2 NaCl or 2 KCl yield. The manufacturer of CosaminDS (a glucosamine/chondroitin combination product which is Approved in this Review) claims to be the exclusive licensee for this form of chondroitin. Ingredients https://www. Inc. which is also the form that's been used in most studies. For more information see CL's Multi-Label Testing Program. or after initial posting of this Product Review. 1.com (without tax or shipping). Liability to any person for any loss or damage caused by errors. Both glucosamine and chondroitin should be taken in divided doses throughout the day (that is. Glucosamine sulfate (more correctly called glucosamine sulfate 2-KCl (the KCl stands for potassium chloride) or glucosamine sulfate 2-NaCl (the NaCl stands for sodium chloride)) are the forms that have been used most often when glucosamine alone has been studied. Not to be reproduced. but as parts of a complex. CL cannot assure that results for other samples will be the same as those listed above. Supplement labels typically provide the amount of "free" chondroitin in the product. once daily)* Mfd. information about the products listed above is based on samples purchased by ConsumerLab. the number of pills needed daily varies and this should be considered when comparing the costs https://www. its officers or employees. a label indicating 1200 mg of chondroitin sulfate (90% by USP method) is really only providing 1. Although the hydrochloride form provides more free glucosamine than the sulfate forms.080 mg of actual chondroitin after adjusting for 90% purity. Glucosamine hydrochloride (HCl) is the form that has been used most often in studies where glucosamine is combined with chondroitin.200 mg of chondroitin sulfate from the sodium salt form will contribute 105 mg per day of sodium. Copyright ConsumerLab. People watching their salt intake may. * Tested through CL's Voluntary Certification Program prior to. Chondroitin is typically sold as chondroitin sulfate. difficult to say whether either form works better than the other. non-capsule. or cited in any fashion without the express written permission of ConsumerLab. Chondroitin can also vary in terms of the chain length (and molecular weight) of its components — although the clinical significance of this is not well known. Be aware that 1. CL did not test this product for chondroitin sulfate and MSM as the label did not list individual amounts of these ingredients.246 mg of free glucosamine while 1. The information contained in this report is based on the compilation and review of information from product labeling and analytic testing. Because the amount of glucosamine or chondroitin per pill varies across products. The information in this report does not reflect the opinion or recommendation of CL. the sample was composed of one or more products from a lot having an expiration date (if labeled) later than the date of testing. however. 500 mg of glucosamine HCl or sulfate and 400 mg of chondroitin sulfate three times per day or 750 mg glucosamine HCI or sulfate and 600 mg chondroitin sulfate two times per day). CL applies what it believes to be the most appropriate testing methods and standards. However. the amount of true (or "free") glucosamine per gram of each compound varies greatly.500 mg serving. 1. but it is possible that longer length molecules are also digested to shorter length units. 2 3 Not tested but claimed on label. and non-time release formulations are tested for disintegration. Manufacturers may change ingredients and label information at any time. There appears to be no conclusive evidence that one form is better than another. Unless otherwise noted. It is. it may not be the same as what was tested. Because ingredients and labeling may vary from lot to lot and there may be a lack of consistency within lots. which tends to range from about 80 to 90%. 2012. LLC. therefore.consumerlab. or inaccuracies in this report is hereby disclaimed.200 mg Chondroitin Sulfate 500 mg MSM $17. want to avoid products made with the form that includes NaCl (sodium chloride). excerpted. 1 Amounts shown are for general comparison purposes and are calculated from the price paid by ConsumerLab. Chondroitin can vary in terms of its purity. omissions.99/16 oz bottle N/A — Not applicable: Only non-chewable. and cost for MSM-Only based on 1.500 mg of glucosamine hydrochloride actually yields 1. at time of. All rights reserved. About 1.com/results/print. All chondroitin from cow or pig sources contain combinations of chondroitin A (or chondroitin 4 sulfate). chondroitin C (or chondroitin 6 sulfate) and a non-sulfated component. So be sure to check labels carefully when evaluating the products you use or buy.com. consider products made with the calcium salt form. Chondroitin sulfate is usually in a salt form to help stabilize it.com/results/print. so don't be concerned if you see "sodium chondroitin sulfate" on the label or "calcium chondroitin sulfate. ** Product identical in formulation and manufacture to a product that has passed testing but sold under a different brand.13/05/13 (liquid.consumerlab. is the same. Results of laboratory studies with cell cultures indicate that shorter length molecules are better absorbed.com (CL) for this Product Review. This is probably of little importance. If a product's ingredients differ from what is listed above. by Botanical Laboratories. respectively. consider choosing a product that does not use the sodium forms of glucosamine and chondroitin. Chondroitin is similar in structure to the blood-thinning drug heparin. It is not an endorsement of any product nor it is it meant to substitute for the advice provided by physicians or other healthcare professionals. If a positive response is not experienced within 3 months. which has a faint sulfur-like or garlic smell. which is 2.13/05/13 https://www. While this amount of manganese is not dangerous if taken just during a few weeks of initial therapy. it may be possible to reduce the dose after the first few months. or headache. ConsumerLab.asp?reviewid=jointsupplements 10/11 . When buying an MSM product. Too much manganese (over 11 mg per day) for an extended period of time carries a risk of neurological side effects. Chondroitin sulfate is a component of a substance called versican that appears to support the spread of prostate cancer. Glucosamine is an amino sugar. chondroitin.3 mg per day for men and 1. men with. so use of chondroitin with blood-thinning drugs or daily aspirin therapy may cause bleeding in some people. sold under the trademarks Regenasure and GreenGrown. https://www. Some products claim as little as 167 mg of MSM per pill. The safety of MSM hasn't been evaluated for children or for women who are pregnant or breast-feeding. they should return to the full dosage. a recent clinical study did not find evidence of such an increase. skin reactions. but be aware that. so it may theoretically affect blood sugar levels. Concerns and Cautions: Glucosamine and Chondroitin: Glucosamine and chondroitin. MSM: MSM is generally safe when taken at recommended dosage levels. so it's difficult to determine the optimal dose. Arth & Rheum 2011).500 mg. MSM: There are few well-controlled published clinical studies for MSM. While chondroitin sulfate itself has not been shown to have this effect. drowsiness. be sure to let your healthcare provider know if you take glucosamine or chondroitin. Before starting on any supplement for joint pain. Beneficial effects from these products may take anywhere from several weeks to 3 months. However. The information contained herein should not be used for diagnosing or treating a health problem or disease. To further assist consumers.asp?reviewid=jointsupplements glucosamine or chondroitin per pill varies across products. Those under 115 lbs could try going to 500 glucosamine and 400 chondroitin. or at risk for. but be aware that MSM occasionally causes nausea. Information on this site is provided for informational purposes only.8 mg per day for women — an amount similar to that consumed in the typical American diet. in some individuals. Some glucosamine-chondroitin products may contain manganese (which may potentially aid bone formation). or MSM would be inappropriate. it should not be exceeded for an extended period of time.com/results/print. as discussed above. Losing weight and switching from high-impact to low-impact sports are also advised for people with osteoarthritis.com's standards.com/results/print. and if you change the dosage. others. increasing the INR (international normalized ratio) and the risk of bruising or bleeding in people using warfarin (Coumadin). There are also reports of glucosamine and glucosamine/chondroitin affecting coagulation. The manganese levels in such products typically exceed the recommended intake.consumerlab.200 mg chondroitin per day) could try reducing the dose to 1. ConsumerLab. Those over 200 lbs should stay on the full dosage. When improperly manufactured. The most commonly suggested daily dose is 2 grams. it can be contaminated with DMSO. gout or other diseases for which treatment with glucosamine. diarrhea. glucosamine can cause gastrointestinal discomfort. which may be caused by rheumatoid arthritis. recommendations go as high as 8 grams/day. A person under 200 lbs with a positive response to the full dose (1500 mg glucosamine and 1. consult a physician to be sure of your diagnosis. A vegetable-based glucosamine is now available.com will periodically re-evaluate these products to ensure their compliance with ConsumerLab. If you need to watch your sodium intake. Because the glucosamine in supplements is commonly derived from shrimp or crab shells. as much as 1. If you use blood-thinning drugs. High-quality MSM is an odorless white crystalline powder. However. 800 mg once daily of a highly purified (95% pure) chondroitin sulfate has been used (Gabay. MSM may also have an aspirin-like effect and shouldn't be used by patients already taking blood-thinning drugs. the dosage. and headache and chondroitin can occasionally cause stomach upset.com licenses its flask-shaped CL Seal of Approved Quality (see The CL Seal) to manufacturers for use on labels of products that have passed its testing. and the products aren't likely to help those with severe osteoarthritis — where cartilage has worn down so much that bones rub against bones. prostate cancer may want to avoid chondroitin sulfate until more is known. unless medically supervised. so individuals in these groups should avoid using MSM. For treating symptoms of osteoarthritis of the hand. This is particularly important with hip pain.consumerlab. the number of pills needed daily varies and this should be considered when comparing the costs of products. damaged blood supply. recommendations can range from 500 mg to 3 grams (1. are generally considered safe for healthy people not taking other medications.000 glucosamine and 800 of chondroitin. continuing with the supplement or increasing the dose is not indicated. consider this variation. taken in appropriate amounts. If symptoms return. people allergic to shellfish may experience an allergic reaction to these products. If the supplements are having a beneficial effect. infection.000 mg = 1 gram). Occasionally. com/results/print. store or distribute content from this site without permission. It is otherwise unlawful to print. download.com.consumerlab. A single copy of this report may be printed for personal use by the subscriber. https://www.com. ConsumerLab. All rights reserved.com/results/print. 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