www.jntuworld.com www.jwjobs.net GATE 1991 SECTION A PY -1 Multiple Choice Questions 1.1 Cortisone is (a) 4 – Pregnane-12 , 21 diol- 3, 20- dione (b) 4 – Pregnane-17 , 21 diol- 3, 11, 20- triione (c) 4 – Pregnane-16 , 21 diol- 3, 11, 20- triione (d) 4 – Pregnane-17 , 21 diol- 3, 11, - dione 1.2 Pregnenolone, an intermediate in synthesis of steroids, on oppeneur oxidation gives (a) Progesterone (b) 9 - flurocortisone (c) Triamcinolone (d) methyl Prednisolone 1.3 In congestive cardiac failure, digitalis glycosides are used because it increases (a) The heart rate (b) The force of myocardial contraction (c) The venous pressure (d) The cardiac filling pressure 1.4 Shrinkage of gel by extrusion of lipids is called as (a) Syneresis (b) Dilatancy (c) Plasticiy (d) Ebulition 1.5 The sweetening agent commonly used in chewable tablet formula is (a) Sucrose (b) Cyclamate Sodium (c) Saccharin Sodium (d) Mannitol 1.6 Carbamazepine is tricyclic antidepressant, It is classified as (a) Benzodiazepine (b) Arylalkonolamine (c) Iminostilbene (d) Benzimidazole 1.7 Sulfa drugs can be conveniently estimated using the reagent (a) 4,4 Dithiobis – (2-nitrobenzoic acid) (b) Tris-(hydroxyl methyl) amino methane sodium nitrate (c) N-(1-nepthyl) ethylene diamine (d) N-ethylmalcimide J T N W U R O D L 1 www.jntuworld.com jntuworld.13 Resolution of monochromator is the ability to distinguish (a) As a separate entities adjacent spectral features (b) Separation of different colours (c) Separation of UV light and Visible light (d) Dispersing Characteristics J T N W U R O D L 1. Optometric and Catabolic 1.12 Rancidity of fat is due to (a) Oxidation (b) Saponification (c) Hydrolysis (d) Neutralization 1.5 mg (d) 2.jntuworld. Myotropic and Anabolic (b) Progestinal.5 mg (b) 1.8 Testosterone can be commercially synthesis from (a) Sarsapogenin (b) Mexogenin (c) Oubagenin (d) Halotensin 1.jwjobs.www.net 1.14 Important activity noticed in testosterone (a) Androgenic.10 The neurotransmitter is released at the sympathetic nerve fiber is (a) Epinephrine (b) Norepinephrine (c) Acetylcholine (d) Physostigmine 1.com . (a) 0.com www.11 The dose of the drug is 5 mg/kg body weight.9 Ehlrich’s reagent is (a) Bismuth iodide solution (b) p-dimethyl aniline solution in alcohol (c) p-dimethyl amino benzaldehyde solution (d) p-dimethyl aniline solution in alcohol 1. Myotropic and Anabolic (d) Androgenic. How much the drug is required for the boy of 12 years who weigh 21 kg.0 mg (c) 1.15 Fruits which are derived from plants Umbiliferae are all of the type (a) Cremocarp (b) Pericarp (c) Epicarp (d) Mesocarp 2 www.0 mg 1. Myotropic and Anabolic (c) Estrogenic. 23 The ilkovic equation in the polarographiac measurements is given by (a) 𝑉 = (c) 𝑣 = 𝜋𝑟 2 ∆𝑃 8𝑙 .net 1.com www.com .18 Vinblastin and Vincristine act by (a) Interfaring with synthesis of transfer RNA (b) Inhibition of fragmention of DNA (c) Binding to protein (d) Incorporating into folic acid metabolism 1.17 Erythromycin is an antibiotic.jntuworld.16 Amygdalin on hydrolysis gives (a) Mendelonitrile + Benzaldehyde (b) Mendelonitrile + Benzaldehyde + Glucose (c) Mendelonitrile + Glucose (d) Mendelonitrile + Benzaldehyde + Rhamnose 1. It belong to the class of (a) -lactum (b) Aminoglycoside (c) Macrolide (d) Peptide 1.jntuworld.www.21 The presence of unpaired electron in metal ion complx meant for special analysis is called (a) Paramagnetic (b) Dimagnetic (c) Bimagnetic (d) Unimagnetic 1.life of drug (a) It is a constant physical property of the drug (b) It is a constant chemical property of the drug (c) It may be increased in patients with impaired renal failure (d) It may be decreased in patients by giving the drug by rapid IV injection 1.𝑛 𝐻2 𝑟2 𝑒 2 𝑚 J T N W U R O D L (b) 𝑖 = 607 𝑛𝑐 𝐷1/2 𝑚2/3 𝑡1/6 (d) 𝑃0 − 𝑃 = 𝑃0 (1 − 𝑒 −𝑎𝑏𝑐 ) 3 www.20 Select the drug that will aggravates bronchial asthma (a) Amphetamine (b) Morphine (c) Propranolol (d) Tubocurarine 1.22 The biological half.19 Water attack test is used to identity the alkalinity in (a) Type I glass (b) Type II glass (c) Type III glass (d) All the three types 1.jwjobs. 24 The vitamin which has deodorant property is (a) Vitamin A (b) Vitamin C (c) Vitamin D (d) Vitamin E 1.26 Subcoating is given to the the tablets (a) To increase the bulk (b) To avoid deterioration due to microbial attack (c) To prevent the solubility of in acidic media (d) To avoid stickiness 1.com www.jntuworld.net 1.jntuworld.31Digoxin: (a) has its action terminated by metabolism in the liver (b) has a plasma t1/2 of 6 hours (c) should be given half of its normal dose to hypothyroid patients (d) provide benefit in atrial fibrillation by increasing the force of contraction 4 www.27 Water resistance of glass container are tested by measuring (a) Amount of alkali released into water (b) Amount of acid released into water (c) Estimation of silicate level (d) Turbidity 1.jwjobs.25 A type of flow in which viscosity increases when the substance agitated is (a) Plastic (b) Psudoplastic (c) Dilatant (d) Thixotropy 1.30 The stationary phase in TLC is (a) Adsorbent (b) Liquid held between glass plate and adsorbent (c) Glass plates (d) None of the above 1.com .www.28 The pH of pharmaceutical buffer system can be calculated by (a) pH partition theory (b) Noyes whitney law (c) Henderson-Hasselbaltch equation (d) Michalis Menten Equations 1. Its structure is (a) HOOC H C NH2 H2 C (c) HOOC H2C H2 C J H2 C T N W U (b) R O O H N C D L CH2CH2Cl2 N N O N(CH2CH2Cl)2 O O P NH N(CH2CH2Cl)2 (d) N(CH2CH2Cl)2 1.29 Chlormbucil is an anticancer drug. 37 Lactose is the most widely used diluent in the tablet formulation.36 The chemical reaction shown below can be carried out using the reagent listed below from A to D. HN CO CH3 COCl + (a) CH3MgBr (b) Cucl2 (c) AlCl3 (d) CH3COONa 1.35 The formula for the preparation of ascorbic acid injection I.jntuworld.www.33 Morphine is the drug of choice for (a)Urinary tract infection (b) Colic pain (c) Bronchial asthma (d) Cardiac asthma 1.com www. (c) Stimulate β receptors but block α receptor.34 Drug used in treatment of bronchial asthma usually (a) Block both α and β adrenergic receptors (b) Stimulate α receptors but block β receptor. Indicate the correct one.net 1.38 The area under the serum concentration time curve of the drug represents: (a) The biological half life of the drug (b) The amount of drug in the original dosage from (c) The amount of drug absorbed (d) The amount of drug excreted in the urine J T N AlCl3 W U H3COCHN R O O C D L 5 www. may include (a) Glacial acetic acid (b) Dilute hydrochloric acid (c) Propylene glycol (d) Sodium carbonate / sodium bicarbonate or sodium hydroxide in water 1.32 The ingredients mentioned below are commonly used as the coating agents for film coating EXCEPT (a) Cellulose acetate phthalate (b) Carnauba wax (c) Hydroxy ethyl cellulose (d) Sodium carboxy methyl cellulose 1.P. (d) Stimulate α and / or β receptors 1.jntuworld.com . However it is not used in the formulation of one of the following (a) Pyrazinamide (b) Ibuprofen (c) Sulfacetamide (d) Isoniazide 1.jwjobs. T = I /I0 2. Procaine (a) COO -CH2.5 Match the suitable test organism for assaying the antibiotics mentioned below 1. Micrococcus leteus 6 www. Match them.com www. Lidocaine C. Rifampicin B. log I0/I = abc 3. 5 ppm 2. Opthalmic preparations A. Hemolytic anaemia 2. a = bc 2. 25 ppm E. Hard gelatin capsule shells B.CO . Dibucaine R O D L (b) COO .jntuworld. Absorbance D.2 Permitted limit of ethylene oxide in various products are mentioned below. Tetracycline D.N (C2H5)2 2.CH2-CH2. Stypylococcus saprophyticus 4.CH2. Transmission C. Bacillus cereus 2.net 1. Absorptivity B. bacillus subtilis E. Streptomycin D. 35 ppm 2. Beer’s Law A. Doxycycline A. Ototoxicity 2. A = log (I / T) 4.com . Erythromycin B. Intra uterine devices D. 1.39 Vinca alkaloids are isolated from (a) Catharanthus roseus and contain indole and indoline moieties (b) Rosco chromogens and contain indole and indoline moieties (c) Catharanthus roseus and contain quinoline and quinaldine moieties (d) Catharanthus indicus and contain indole and quinoline moieties 1. Surgical material C. Nephrotoxicity E.CH3 (c) COO -CH2. Benzocaine D. Cephlosporins C. Streptomycin C. Chlormphenicol A. CNS toxicity 4.jwjobs. Hepatotoxicity 3.jntuworld.CH3 (d) NH.CH2-N (C2H5)2 J T N W U B.1 The antibiotics and their adverse effect are mentioned below 1. 15 ppm 4.3 Expression of the following terms are given A to E.40 Aprotic solvent have (a) Acidic properties (b) Basic properties (c) Both acidic and basic properties (d) No acidic and basic properties PY-2 Match the following 2. match them correctly A. Bacillus pumilus 3.www. Butesin E. 10 ppm 3.4 The side chain as given from 1 to 4 is present in local anesthetics listed A to E. Match them correctly 1.CH2 . – C2H5. – C2H5. Sec pentyl 2. Isoniazide D. Histolytica A. M. 10 – 10-2 E. E.Rays D. isopropyl 4.UV. methamine E. Nephelometer J T N W U R O D L 7 www.Isobutyl benzene E. 4 NH2 quinoline 4. 4-OH phenylacetamide 2.jntuworld. Ferrous ions B. Match them correctly. γ –picoline 3. Chlorthiazide B.Rays A. leprae D. Inhibit Carbonic unhydrase E. X.jwjobs. – C2H5.Rays C.jntuworld.CH (CH3)2 3. S. Colorimeter 2. 1.Rays B. pH meter 3. 1.8 Match the correct mechanism of action for the diuretic agents mentioned below 1. Barbital B. Thiamine A. Increases the serum K+ level 2. 10-8 – 10-6 4. Flurimeter 4.falciparum B.7 The causative organism of the disease is given and the drug used for the treatment is indicated in A to E.com . Match them properly to identify correct structure.10 The following drug can be prepared starting from the intermediate given in A to E.net 2. Acetazolamide A. colourimeter E. Visible . Match them. Probarbital C. Clofazimine 2. 10-5 – 10-4 3. – C2H5 2. Inhibit electrolyte re-absorption in the distal portion of ascending limb of the loop 2. P. Atenolol A. 10-6 – 10-5 2. Inhibit active Na+ secretion.OH piperidine 2. Spironolactone C. Triamtrene D. Match them 1.9 The position -5 of barbituric acid analogous mentioned below have substituent’s as indicated in A to E. 4-(p-chlorophenyl) 4. . haloperidol C. typhi C. Barium sulphate D.com www.6 The region of spectrum for the following are given in term of wavelength (cm) in A to E. Chlormphenicol 3. Acidity of carboxylic acid C. Mebendazole 2. decreasing K+ Excretion in distal nephrone 4. Ibuprofen B. Phenobarbital A. 1.11 Choose the most appropriate instruments / apparatus listed from A to E for the study of the following 1. Pentobarbital D. Competitively antagonizes aldesterone 3. Infrared. 10-2 – 10 2.www. – C2H5. Emetine 4. Nystatin C.12 Following drugs are tested with reagents listed in A to E. Cluster crystal of calcium oxalate A. Preservatives A. Fennel B. Standard for ophthalmic preparations 4. Antimony trichloride in chloroform E.13 match the antibiotics with their mechanism of action correctly 1. Inhibition of protein synthesis E. Match them 1. Digitalis purpurea E. Aids Solubility B. Sea wood 4. Mineral oil 2. Rifampicin D. Match them. 2. 1. Synthetics 2. Titanium dioxide 4. 1. Essential oil 3. Alexandrian senna 4. Opacifier D. Potassium bismuth iodide solution 2.17 In the preparation of capsule shell the ingredients mentioned are present for the specific purpose. Match them correctly 1. Organoleptic additive C. karaya A.jntuworld.net 2.com . Seed extract 8 J T N W U R O D L www. Coriender D. Inhibition of nucleic acid synthesis 2.com www. Standard fro cosmetics 3. Cinamon bark 3. Phloem fibres C. Life period of the drug E.jwjobs.15 The source and constituents of the following umbelliferous fruits are listed in A to E. Coal tar colour used in cosmetics. Inhibition of growth by competitive antagonism 4. Vitamin A D.www. Choose the appropriate one. 2. Standard for poison 2. Inhibition of cell membrane function 2.18 The emulsent and their sources are given below. Inhibition of cell wall synthesis 3. Glandular trichomes D. Stramonium leaves 2. Dextran B. Schedule Q B. Schedule S C. Schedule P A.16 Given below are the microscopic diagnostic features of the drug listed in A to E. α –nepthol in alcohol 2. Ampicillin A. Anethum graveolens – Cuminic aldehyde 4. Ninhydrin 4. Caraway A. Nicotine C. Fumaric acid E. foeniculum vulgare – Anethole / Fenchone 2. Carum carvi – Carvone 3. Carageenan B. Gelatin D. Asparic acid A.jntuworld. Candelabra trichomes B. match correct schedule to their respective titles 1. Gum exudates E. Dill C. Schedule FF D. Coriendrum sativum – linalool 2. Propyl paraben 2. Verbascum thapus 2. Match them correctly 1.6 dichloro phenol indophenol 3. Gaur C. Chlormphenicol B.14 As per drug and cosmetics acts. Collegen 3. ascorbate) Give reaction PY 5 a) Give the expression for stoke’s law b) What does it indiacates PY 6 a) How do you test for rancidity of archis oil IP ? HCl A + B + C what are A. C A. Biological assay using prostate glands of immature rats 2.P.0 .B. G C.www.jwjobs.net 2. B. Heparin sodium injection I. Mixed gonadotropin antitoxin I.jntuworld.P. E. I. F B.P. Standards for surgical dressing 2. M D. What is HLB value of ester ? 9 www. What are they ? Give complete equation PY 4 Give the IP assay method for sodium ascorbate IP (monosodium -1. structural formulas of some biological important purine bases b) What is biuret test? Which type of compounds are usually tested ? c) Caffeine on treatment with KClO3 and HCl gave two products.Terpineol rearrangment A B C2H5ONa HCl C H2SO4 H2O D J T N W U R O D L PY 8 a) What is HLB ? b) Draw the HLB scale and suggest suitable classification for various surfactant on basis of HLB value of scale c) A polyhydric alcohol fatty acid ester gave a saponification number 48. the corresponding acid gave an acid number of 280.jntuworld. Biological and special products 3. Match them correctly 1.P. Biological assay using clostridium welchi Type A antitoxin 3. C. Gentamycin injection I. D. Equipment etc. C. GMP requirement of factory premises plants. A.com www. Biological assay using sheep plasma E. match them correctly 1. antigens and Sera 4.P.com .19 List below are some schedules 1 to 4 and the rule A to E. and D ? NaCl alpha . C ? Ascorbic acid Boil b) PY 7 Give complete equation what are A. B. Provision applicable to vaccines. Microbiological assay using method A 4. 2. toxins.20 preparation listed 1 to 4 are assayed by the given in A to E.M. Chorionic gonadotropin inj. Biological assay using human plasma SECTION B PY 3 a) Give the systematic names. List of medicine required to be taken only under supervision of R. com . b) A 250 ml infusion contain 18.liquid and high pressure liquid chromatography b) Define : Gradient elution 10 www. What is Cicatrix? PY 12 Draw complete equation to show what happen when following reaction are carried out ? a) Tropine is treated with mendalic acid b) Morphine is demethylated and product allylated c) Cocaine is treated with hot dilute acid PY 13 a) Write the full structure of any three drugs which are prepared starting from m-choroanilline. J T N W U R O D L PY 16 Why glucouronidation is most common conjugative pathway in drug metabolism ? Give three resons. Answer should not exceed 4 sentence in each case a) nitrazepam b) Ethacranic acid c) Hydralazine HCl PY 10 a) What is passive diffusion? Give the mathematical representation of Ficks law of diffusion. Give one example of one drug molecule.jwjobs.jntuworld.net PY 9 Give the pharmacology of the following.75 x 10-5. b) The Ka of acetic acid is 1.jntuworld. PY 17 a) What is major difference between the following chromatographic techniques ? i) Paper and thin layer chromatography ii) Gas.65 g of potassium chloride. Write the structure and number of the positions. b) Give chemical nomenclature of chlordiazepoxide PY 14 a) Name the three physiochemical properties which are important for drug activity.www.com www. How many milliequivalent of KCl are present ? PY 11 a) Suggest the names of important types of stomata according to the characters of guard cells b) Give the name of 3 different types of trichomes present in medicinal plants. Calculate pKa PY 15 The general structure of tetracycline is an octahydro analogous of naphthalene on which a number of substituent’s are possible. 5 % solution of procaine hydrochloride isotonic with blood plasma. Piperazine + Diethyl carbamyl choride C 4.com . a. of 1% solution of procaine HCl is -0.jwjobs.2 PY 21 The IR absorption band of an organic compound are observed as follow: 3080. C + Methyl iodide D PY 19 a) Write the toutomeric form of barbituric acid. b) Give synthesis of metronidazole PY 20 caffeine has the UV absorption maximum at 272 µ 0. 1680.0 cm cell at 272 µ was 0. A + isopropylene B 3. Exactly 10 ml of this solution was diluted to 100 ml and absorbance of this solution in 1.jntuworld.1360. 1.0 c of cell. 1430.58C.com www.Calculate the concentration of unknown solution of this drug which gave an absorbance of 1. J T N W U R O D L PY 25 a) b) c) Mention the possible drug-drug interaction of the following combinations Aluminum hydroxide gel with isoniazide Aspirin with heparin injection Phenytoin with sulphasomidine PY 26 Define the following terms used in tablets coating a) Opaquants b) Bridging c) Compression coating PY 27 Define the term mentioned below used in aerosol technology : a) Leak test b) Biological test c) Spray test 11 www.C. Indicate the functional groups corresponding to these bands (The empirical formula of this compound is C8H8O) PY 22 Define the following term used in parenteral filtration: a) Polishing b) Cold sterilization c) Impaction PY 23 Describe the terms mentioned below and give two example of each a) Antipruritis b) Keratoplastics c) Keratolytics PY 24 a) What is sterile water for injection? How you will identify the oxidisable impurities in it ? b) Calculate the amount of sodium chloride required to adjust 500 ml of a 0.854 .www.022 in 2. Complete the equation by writing the structures.B.D.jntuworld. The molecular weight of caffeine is 194. The F.1316 g of this drug was dissolved in enough water to make 1 lit. and D are formed by the following chemical reactions.12 C and sodium chloride is -0. 755 and 690 cm-1 . Calculate molar absorptivity of caffeine b.P. 1580.net PY 18 Product A. α – napthol + Epichlorhydrine A 2. 2960. 23 1.1 1.16 1.26 1.18 1.3 1.7 1.4 1.17 1.14 1.6 1.25 1.www.35 1.13 1.31 1.36 1.28 1.20 C A A A A C C C B C 1.33 1.com .24 1.27 1.32 1.com www.39 1.40 D B B C D C D C A D J T N W U R O D L 12 www.2 1.15 1.22 1.12 1.37 1.9 1.5 1.net Solution of GATE 1991 1.30 A C B B C A A D A A 1.11 1.10 B A B A D C C A C B 1.jntuworld.34 1.19 1.21 1.jwjobs.29 1.8 1.jntuworld.38 1.