بسم الله الرحمن الرحيمDermatology exam part one 12/2013 1) The skin compartments, dermis& epidermis are: a. b. c. d. Independent functionally. Develop from the same origin. Have little anatomical difference. Inter dependent functionally. ANS: D 2) Regarding cell differentiation the following factor affect its sequence: a. b. c. d. e. Calcium concentration. Protein kinas c. Retinoic acid. Expression of k1,k10 Interleukin 1. ANS: C 3) Profilaggrin: a. b. c. d. e. A large calcium binding glycoprotein. Expressed in chromosome 1q21. High calcium concentration result in its assembly. Synthesized in spinous layer. Contain 15-20 repetition of filaggrin. ANS:B 4) Filaggrin: Melanocytes Merkls cells. Completely loses keratin 5 &14 Have fine and short keratin fibrils. c. c. Cells filled with glutamine. ANS: B . c. e. ANS: D? 6) periderm: a. Highly differentiated cells. Have round cell nuclei. d. ANS:B 5) The following cells are mesenchymal in origin: a. b. Is a molecule that organizes intermediate filaments into macromolecules. It eventually shed out into the amniotic fluid as development proceeds. d. Disappear in the corneal layer. Stem cells. d.a. Cationic protein rich in histamine. Keratinocytes. Found in the upper part of epidermis. Its cells undergo apoptosis and disappear. c. b. ANS: C 7) Spinous layer: a. b. b. Langerhans cells. b. . b. Phospholipids Glycolipids. d. ANS:C 11) The antimicrobial effect of the skin can organized by: a. c. c. b.8) The skin layers in an embryo of 6 weeks: a. d. Desmosomal protein in 10 week. Single layer of periderm. Single layer of germenativum cell. Glycolipids. ANS:D 9) Which of the following regarding development is correct: a. d. Nail in 25 wks. Pyrolidon. ANS:A 10) Which of the following is a component of sebum: a. Filaggrin in 12 wks. Specific peptides. c. Glycoprotein. Three layers. Hair follicles in 15 wks. d. c. b. Squalene. Phospholipids. Two layers. Desmoglyins. Carpoxyurocrnic acid.e. Desmoglyins. e. ANS: C 15) Regarding formation of corneal envelop: . d. Scales. Claudins & ocludins Connexons. c. d. Desmoplakins & desmoglyins. ANS:A 12) In the Desmosomal junctions which of the following takes part: a. Desmocolins. ANS: C 14) In alopecia areata the following feature is present: a. Desmoglyins & Desmocolins only. Itching Exclamation mark hair. d. Desmoglyins. Catinins. ANS:E 13) In tight junction the following molecules are included: a. c. Desmoplakins & Desmocolins. Papules. c. b. b. b. Organized by 3 compartments. Purely organized by lipid devoid protein corneocytes. b. Lipids have no role in envelop formation. c. Organized by single compartment. Pigments are passed to other cells in vesicular structure. d. Have 5 subtypes. Have granulated cytoplasm. Contain only one pigment. b. d. ANS: D 16) Langerhans cells are: a. They travel to epidermis as melanocytes. b. e. b. d. Cross link with involucrine. . Round in shape. Pigments are passed to other cells through MELANosmoses ANS: A? MELANOBLASTS 18) SPRP: a. Are pigmented cells. Organized by two compartments.a. c. c. ANS: D 17) Regarding pigmentary cells: a. Localized in spinous layer. c. Tetracycline. e. e. 100/kg /day. Synthesis stimulated with ultraviolet light. b. d. Clofazimine. c. c. Corticosteroids. 20/kg /day. Dapsone. Is formed of two chains. Some are helical others are not. d. 10/kg /day ANS: E 21) The antilepromatous drug that has inflammatory action: a. 2 mg /kg /day. d. Undergoes glycosylation before expressed procollagen. c. SPRP 2 is scanty in vivo. d. b. ANS: C 19) Collagen: a. Collagen 4 has staggered appearance. . Rifampecine. 50/kg /day. ANS: C 20) Griseofulvin dosage is: a. SPRP3 is much expressed in vivo. b. e. Organism can be isolated from the lesion. c. Bicarbonate & potassium. ANS: D 23) In addition to water what are important components of ORS (oral rehydration salt) was for rehydration: a. e. Chloride & potassium. b. c. Sunken eyes. Lethargy. Depressed anterior fontanel.ANS: A 22) In sever dehydration the following are characteristic features except: a. Tabes dorsalis is a feature. ANS: C 24) Neurosyphills: a. b. d. e. Sodium & lactate. Are reversible. Sodium & glucose. Appears after 6 month from primary chancer. c. Abscess formation. d. ANS: A . Absent tears. d. b. Eager to drink. c. Staphylococcus. Erythromycin. Malignant form . e. d. c. Chlamydia trachomatis. b. d. Streptococcus. Mycobacterium Chlamydia. b. d. Mycoplasma spp. Ciprofloxacin. ANS:C 26) Gonorrheal urethritis best treated by: a. Tetracycline. Niseria gonorrhea. ANS:D 28) Bullous impetigo is caused by: a. Staphylococcus. Procaine penicillin. Deep dirty ulcer. Clean shallow erosion. d. ANS:B 29) Pimphigus is skin condition: a. Caused by microbial infection. e. Streptococcus. Crystalline penicillin. b. Shallow ulcer. b.25) Chancroid has: a. b. ANS B 27) The main causative agent of non specific urethritis is: a. c. Discrete enlarged lymph node. c. T. e. Contain 46 chromosomes. Scabies.c. Gonorrhea. Molloscum contagiosum. b. Kerion. Stored in prostate. d. Contain enzymes in its head aids in penetrating the ovum. Syphilis. Favus. ANS:C 30) The following are STD except: a. d. c. c.capitis. Are motile in seminiferous tubules. Herpes simplex. T. c. ANS: B 31) The following are caused by dermatophytes except: a.corporis ANS: C 32) Regarding spermatozoa: a. Auto immune disease. Piedra. b. d. e. ANS: C 33) Regarding dermis: . b. b. b. Start in T cells. ANS: C 35) The following cause generalized hyper pigmentation: a.a. Remodeling occur only under pathological process. Crohn’s disease. d. The international WHO classification is the latest classification. It is unlike epidermis doesn’t undergo sequential differentiation. b. d. Addison’s disease. ANS: A 34) In Non Hodgkin’s lymphoma the following are true except: a. d. ANS:C 36) The following is best media to grow Chlamydia: . c. c. Tattooing. Structure don’t undergo turnover in normal conditions. Does not commonly extend to other tissue. Structure & organization are not predictable. c. Xeroderma pigmintosa. Affect the lymph nodes. d. G2 takes from 10-12 hrs. G1 is greatly variable in duration. ANS: A 39) In eccrine sweat gland: a. d. c. UN descended testis is prone to be malignant. d. Treated ……. Presence of alfafeto protein. b.a. c. e. b. . The secretory part contain 2 layers one clear cell secrete water & electrolyte & other larger of dark cells. ANS: A OR B 37) The following is true about gonad tumors’ except: a. c. MC MOY cells. MC MOY cells. Blood agar. G0 is constant in the cycle. Seminoma is radio resistant. S phase takes from 4-6 hrs. b. Chocolate agar. Yolk sac of hen. Seminoma is the most common type. ANS: A 38) In the stem cell cycle: a. c. b. c. . 3month in infants 41) Multiple Myeloma all are true except: a. 3 months. The intraepidermal part is known as acrosyringium. 3 days. e. Tinacin Thrombospondin Syndican. b. ANS:C 40) Concerning allergic dermatitis in children it start at the age of: a. ANS: C 3years in children . ANS: E Laminin Vitronictin. IGA the highest immunoglobulin. ANS: B 42) The following are glycoproteins except: a. b. One of the most aggressive tumors. d. 3 years. 5 years. d. 10 years.b. There is a monoclonal raise in the immunoglobulin electrophoresis. e. c. b. Support the sebaceous gland. c. Tetracycline. d. Aids in thermoregulation. b. e. c. Appear from the lateral wall to the hair canal. ANS: B 45) Apocrine gland: a. e. Found in palms & soles. d. Connected to the basement membrane. Villous hair contains medulla. The glands secreting milk is one of forms. Contract in high temperature. ANS: B 46) Regarding hair follicle: a. b. glucose & electrolyte. ANS: C? 44) The following is true about erector Pilli muscle: a. Anti androgens. Sweat contains water. Steroids. Retinoic acid. Develop in second month. d. Dapsone. .43) The following are used in treatment of acne except: a. c. e. b. ANS: D 49) Psorriasis is considered as systemic disease the most common system involved with skin: . c. b. Highly permeable for covalent substance.medulla . e. Consist 2% of the dermal molecules.b. Are present in small amounts in the dermis. Are small molecules. The order of layer from inside to out side is (cortex . Water is slightly permeable. ANS: A 48) Epidermal barrier: a. Soluble substances penetrate easily. ANS: B 47) Proteoglycan & gags: a. Terminal hair grows vertically. The inner rout sheath melanocytes. Is purely mechanical barrier. Hold till 2000 of it weight water. Have specific core protein in proteoglycans. c. Differentiation & keratinization continue till the end of hair shaft. d. c. d.inner rout & outer rout sheath) d.Huxley . Have large collagenous fibers. d. e. Collagen 9. ANS: C 52) Regarding papillary dermis: a. ANS: E 51) Which of the following is immune localized to basement membrane: a. Nervous system. c. Collagen 1. Blood capillaries pass in couples to each dermal papilla. Respiratory system. Articular system. . Topical antifungal. c. b. Heparan. d. e. GIT Urinary system. Plectin. Itraconazol. d.a. Griseofulvin. Entacitin. c. b. c. b. Ketoconazole. d. e. Metronidazole. b. Contain elunin elastic fibers. ANS: E 50) Best treatment for tinia capitis is: a. Lipocytes develop in the 20th week. d. e. ANS:E 53) Adherent junctions: a. Crowding of the newly formed mitotic cells. Decrease in number with age. Down regulation of Þ6ß4 integrins. Transfer cytokines & growth factors to the epidermis. b. b. . b. c. Cytokines guard the movement. c. Growth factors controls movement. Some premature as macrophage. ANS: A Is absents in & male genitalia. ANS: C 55) Subcutaneous tissue: a. Is the major type of junction in skin ANS: A 54) The up words movement of differentiating cells from the basal layer is depend on: a. d. d. Connect neighboring cells. Damage of the desmosomes & hemidesmosome.e. Density is affected by the body site & sex. Adipocytes stores but not produce fats. c. d. d. e. ANS: A 57) Dermis: a. ANS: D 58) The main lipid component in the corneal envelop is: a. Produce interleukin 1. e. . Ceramides. d. Are less active than white fat. Lymphocytes & plasma cells are not found usually in normal skin. Form 40% of bulk of skin. b. Cholesterol. Triglycerides. Is mono loculated. c. Phospholipids. Anchoring filaments connect the LD to the upper dermis. c. c. Proteoglycans & gags are the only ground substance.56) Brown fats: a. Have no mitochondria. Free fatty acids. b. Mainly found in the retroperitoneal area. Is completely tensile but restricted pliability. b. ANS: C 59) In the DEJ which of the following is true: a. d. c.b. ANS: B . Laminin 5& 6 is the major component of lamina Lucida.