Osun State University, Osogbo, Nigeria.DEPARTMENTAL CURRICULUM Curriculum for B.Sc. Degree in Biochemistry 100 Level Harmattan Semester Course Code Course Title Pre- Units Status requisite CHM 101 General Chemistry I - 3 C CHM 107 Experimental Chemistry I - 1 C PHY 101 General Physics - 3 C PHY 107 Experimental Physics - 1 C BIO 101 Basic Biology I - 3 C BIO 107 Experimental Biology I - 1 C MTH 101 General Mathematics I - 3 C CIT 111 Introduction to Information and - 2 R Communication Technology FRN 221 Basic French - 2 R GNS 101 Use of English I - 2 R LIB 101 Use of Library - 1 R Total 22 100 Level Rain Semester Course Code Course Title Pre- Units Status requisite CHM 102 General Chemistry II - 3 C CHM 108 Experimental Chemistry II - 1 C PHY 102 General Physics II - 3 C PHY 108 Experimental Physics II - 1 C BIO 102 Basic Biology II - 3 C BIO 108 Experimental Biology II - 1 C MTH 102 General Mathematics II - 3 C 3 C Biochemistry BIO 202 Biological Techniques . 3 C BCH 204 Methods in Biochemistry . 2 C . 2 R CHM 205 Physical Chemistry I . 3 E OR Any other 3-unit course . 2 C CHM 291 Experimental Physical/Inorganic .CIT 112 Introduction to Computer . 2 R GNS 102 Use of English II . 1 C Chemistry GNS 201 Nigerian people and culture . 2 C CHM 207 Inorganic Chemistry I . 2 C BCH 206 Food and Nutritional . 2 R Total 21 200 Level Harmattan Semester Course Code Course Title Pre. 2 C CHM 208 Physical Chemistry II . Units Status requisite BCH 202 General Biochemistry II . 2 R Elective: Take Either CIT 201 Structured Programming . 2 C MCB 201 General Microbiology I . 2 R Programming FRN 222 French for Specific Purposes . Units Status requisite BCH 201 General Biochemistry I . 3 E TOTAL 20 200 Level Rain Semester Course Code Course Title Pre. 3 C BIO 203 Introductory Genetics . 3 C BCH 203 Metabolism of Carbohydrates . 2 R Development TOTAL 21 300 Level Rain Semester Course Code Course Title Pre. 2 C CHM 292 Experimental Physical/Organic .CHM 202 Organic Chemistry I . Units Status requisite BCH 399 Industrial Attachment . 4 C Biological Students CHM 401 Instrumental Analytical Methods . 1 C BCH 391 General Biochemical Methods BCH 292 2 C CHM 303 Organic Chemistry II . 2 C STA 201 Statistics for Agricultural & . 2 C BCH 303 Metabolism of Lipids BCH 201 2 C BCH 305 Metabolism of Nucleic Acids BCH 202 2 C BCH 307 Metabolism of Amino Acids & BCH 202 2 C Protein BCH 309 Membrane Biochemistry . Units Status requisite BCH 301 Enzymology . 2 C GNS 301 Entrepreneurial Skill . 16 C . 1 C Chemistry GNS 202 Osun People and culture . 2 R TOTAL 17 300 Level Harmattan Semester Course Code Course Title Pre. Units Status Code requisite BCH 401 Advanced Enzymology . 3 C Metabolism BCH 499 Research Project . 1 C Macromolecules BCH 404 Bioinorganic Chemistry . 3 C Biology Take Either: MCB 401 Immunology and . Units Status Code requisite BCH 402 Biosynthesis of . 1 C BCH 405 Biotechnology & Genetic . 2 C Engineering BCH 407 Plant Biochemistry . 3 C MCB 408 Microbial Physiology and . 400 Level Harmattan Semester Course Course Title Pre. 1 C BCH 406 Metabolic Regulations . 2 E TOTAL 19 400 Level Rain Semester Course Course Title Pre. 6 C Take Either . 2 C BCH 409 Seminar in Biochemistry . 3 C and Toxicology BCH 413 Bioenergetics . 2 C BCH 411 Pharmacological Biochemistry . 2 C BCH 408 Biochemical Reasoning . 3 E Immunochemistry BCH 417 Biochemistry of Parasite . 2 C BCH 403 Tissue Biochemistry . 1 C MCB 305 Microbial Genetics/Molecular . 1 C BCH 412 Industrial Biochemistry . secondary. methodologies and applications of electrophoresis. methods of isolation and identification. Buffers. Fat and water soluble vitamins. BCH 202 General Biochemistry II (3 Units) (L30: P0: T15) Structure and functions of major cell components. Principles. spectroscopy and spectrophotometry. Glyoxylate pathway. water balance. Water: physical and chemical properties in relation to its biological role. Glycolysis. determination and biochemical applications of these structures. Gluconeogenesis. prokaryotic versus eukaryotic organisms. Phosphogluconate pathway. (2 Units) (L 30: P0: T0) Degradation and digestion of carbohydrates-sugars. the pentose phosphate pathway. pH and PKa values and their effects on cellular activities. Biochemical applications of pH. Chemistry/structures of carbohydrates. Reactions of sugars. instrumentation. Nomenclature of nucleosides and nucleotides. acidity and alkalinity. tertiary and quaternary structures of proteins. Triaclyglycerols. Vitamins and co-enzymes. centrifugation and isotopic techniques. Biochemistry) BCH 201 General Biochemistry I: (3 Units ) (L30 : P0: T15) Chemistry of amino acids. 2 E methods BCH 414 Clinical and Forensic . cell theory. Chromatography. 2 E Biochemistry TOTAL 19 Course Description (B. Cori cycle. Nucleic acids.Sc. Structures and functions of vitamins and co- enzymes. Calvin pathway. (pre-requisite BCH 201) .BCH 492 Advanced Biochemical . the tricarboxylic acid cycle. proteins and their derivatives. The chemistry of lipids. Primary. phospholipids and sphingolipids. effect of acid and alkali on hydrolysis of nucleic acids. BCH 203 Metabolism of Carbohydrates. BCH 204 Biochemical Methods: (2 Units) (L30: P0: T0) Tissue and cell culture techniques. pKa and Buffers. storage polysaccharides and cell walls. glycogenesis and glycogenolysis Disorders of carbohydrate metabolism. Acetic acid as a central precursor for biosynthesis of lipids. Km. ions and inhibitors on enzyme catalysed reactions. triglycerides. glycosylglycerols. diet and disease. pH. Food poisoning and intoxication. Food nutrients. Production. Vmax. preservation and storage of traditional foods-root and stem tubers. Formation of ketone bodies. cholesterol synthesis. purification and characterization of enzymes. xeroderma pigment and skin cancer. Nutritive value of foods-carbohydrates. Allosteric/Regulatory enzymes. isolation. The practical will be arranged on the basis of 3 hours per week for the semester. Michaelis-Menten equation. Nutritional status and nutritional requirements in relation to physical activity and ageing. phospholipids. seeds and grains. BCH 303 Metabolism of Lipids: (2 Units) (L30: P0:T0) Pre. mineral elements and water. vitamins. bilayers Lipoprotein systems. Food processing. energy values of foods and energy expenditure by mammals. Metabolism of purines and pyrimidine nucleosides and nucleotides. Mobilization of fatty acids from adipose tissues. Zymogen activation. monolayers. Mechanisms of enzyme-catalysed reactions. green vegetables. proteins. . Active sites of enzymes. prostaglandins. obesity and undernutrition. BCH 292 Experimental Biochemistry I: (1 Unit) (L0: P45: T0) Practical laboratory exercises designed by academic staff to cut across a wide spectrum of general biochemistry.requisite BCH 202 Genome organization and biosynthesis of proteins. Kinetics of enzymes and inhibition. BCH 301 Enzymology: (3 Units) (L30: P0: T15) Nature and properties of enzymes. fruits and fruit drinks. Oxidation and synthesis of fatty acids. Estimation of kinetic parameters-enzyme activities. prevention and cure. BCH 305 Metabolism of Nucleic Acids: (2 Units) (L30: P0: T0) Pre. fats. Ki etc. Mutation. Lipid micelles. Effects of temperature. Nutritional disorders. abnormalities in nucleic acid metabolism. Recent advances in enzymology. digestive enzymes etc. waxes.requisite BCH 201 Classification of lipids-fatty acids. Integration of lipid metabolism. prevention and therapy. Classification and nomenclature of enzymes.BCH 206 Food and Nutritional Biochemistry: (3 Units) (L 30: P0: T15) An introduction to the theory and application of physical and chemical methods for determining the constituents of food. Oxidative degradation of amino acids and metabolism of one carbon unit. metabolism of inorganic nitrogen. composition and functions of biological membranes. lipoproteins and nucleic acids .BCH 307 Metabolism of Amino Acids and Proteins: (2 Units) (L30: P0: T0) Pre. Multienzyme complexes. Transient kinetic methods. Chemistry of enzyme catalysis. Molecular models for allosterism.the unit membrane hypothesis. bacterial cell wall synthesis of complex lipids. Membrane transport system– active versus passive transport systems. the urea cycle. fractionation. Disorders of amino acid metabolism. Biosynthesis of amino acids and some derivatives. BCH 311 Membrane Biochemistry: (2 Units) (L30: P0: T0) Structure. characterization and classification of membranes.requisite BCH 292 Continuation of previous year’s practical laboratory exercises designed by academic staff to cut across a wide spectrum of general biochemistry. BCH 391 Experimental Biochemistry II: (1 Unit) (L0: P45: T0) Pre. Regulation of enzyme activity and synthesis. BCH 399 Students Industrial Work Experience: (SIWES) (16 Units) Students will be attached to some industrial organizations. BCH 401 Advanced Enzymology: (2 Units) (L30: P0: T0) Steady state enzyme kinetics. The practical will be arranged on the basis of 3 hours per week for the semester. Biological functions of proteins. Natural and artificial membrane bilayers. Enzyme assays. purification and characterization of proteins. mucopolysaccharides. Regulatory enzymes. ionophores. Transport of sugars and amino acids. BCH 402 Biosynthesis of Macromolecules: (2 Units) (L30: P0: T0) Structure and functions of macromolecules. covalent backbone of proteins. glycoproteins. Enzyme reconstitution. Isolation.requisite BCH 202 Amino acids as building blocks of protein. Storage and structural polysaccharides. chemistry and biosynthesis of membranes phospholipids. Criteria for determining purity of enzymes. Amino acid sequence of proteins. Each student is expected to present a seminar on the Industrial work undertaken and submit a written report at the end of the exercise. research institutes or any other suitable place approved by the Department for six (6) months during the long vacation and the Harmattan Semester. Molecular organization of membrane components. Protein isolation. Lignin formation. Genetic transformation. mutagenic agents and their applications to gene – transfer. BCH 408 Biochemical Reasoning: (1 Unit) (L15: P0:T0) Research methods. formation and growth. transcription and translation. Gene mutation. and adipose tissues. photosynthesis. Part of the course will also cover preparation of dissertations or theses. transduction and conjugation. kidney. carbohydrate. Electrolyte metabolism. Structure-function relationship of plant hormones. Hormonal control of metabolism. . Turn-over rates and metabolic pools. BCH 405 Biotechnology and Genetic Engineering: (3 Units) (L45: P0: T0) Replication. gibberellins and cytokinins. BCH 404 Inorganic Biochemistry: (2 Units) (L30: P0: T0) Relationship between the physicochemical properties and biological functions of inorganic ions. biochemistry of plant development. Synthethic growth regulators and herbicides. BCH 407 Plant Biochemistry: (2 Units) (L30: P0:T0) Organization of plants cells. lipid and nucleic acids metabolism. Catabolite repression.a brief review. DNA replication in a cell-free system. Biochemistry of reproductive tissues. end product repression. Structure of eucaryotic genome. Recombination DNA and its applications. papers for journal publications and journal reviews. purines and nucleosides in plants. the lactose operon and arabinose operon. Analysis. Biosynthesis of carotenoid pigments. Plant hormones. Integration of metabolic pathways.BCH 403 Tissue Biochemistry: (2 Units) (L30: P0: T0) Biochemistry of muscles. free amino acids. Nitrogen fixation and sulphur cycle. The plant cell wall structure. Special assignments and essays will be given to students. General metabolism of the brain and neuro-biochemistry. Gene mapping. Detoxification and excretion in tissues. interpretation and inference-drawing from biochemical research data. pyrimidines. Metabolism of auxins. The genetic code and its relationship to cellular functions. liver. Identification of different regulatory mechanism in metabolic pathways. Hybridomas BCH 406 Metabolic Regulations: (2 Units) (L30: P0: T0) The relationship of Kreb’s Cycle to protein. alkaloids and flavonoids. assimilation and dissemination of information. Regulations of enzymes of metabolic pathways-feed back inhibition versus enzyme synthesis. Ligand complexes and their biochemical significance. Nigerian traditional medicinal plants in the management and therapy of common ailments in Nigeria. Fermentations. Biochemical aspects of host –parasite relationships. Pathological urine. Clinical uses of antibiotics. Legal issues in forensic practices. Induction of mutation in micro-organism and plants for the purpose of over production. Methods for screening and selecting micro- organisms of industrial importance. hepatitis etc. Metabolic factors affecting chemotherapeutic agents. Continuous culture methods.malaria. electrochemical potentials. BCH 415 Basic Immunology and Immunochemistry (3 Units) (L45: P0: T0) Basic concept of immunology. regulation of ATP production. strain selection/development and enhancement. amino acid antibiotics and other secondary metabolites. preservation and analysis of materials of forensic interest. Antigens. taste enhancers. Classification and structural motifs of immunoglobulin. The chemostat and its application in industrial fermentation. Gene dosage and its application in industrial processes. antibodies and their reactions. BCH 414 Clinical and Forensic Biochemistry (2 Units) (L30: P0: T0) Diagnostic enzymes. The physiological and biochemical action of some selected drugs. Over production of metabolites. chemical potentials. BCH 411 Pharmacological Biochemistry and Toxicology: ( 3 units) (L30: P0: T15) Cellular metabolism in infected cells. Process evaluation and development. oxidations and reductions. BCH 413 Bioenergetics: (2 Units) (L30: P0: T0) High –energy compounds. Drug resistances and other factors affecting drug efficacy. toxin etc.BCH 409 Seminar: (2 Units) (L0: P90:T0) A seminar to be delivered by each student following intensive literature review on an approved relevant topic in biochemistry. Application of biotechnology in forensic practices. BCH 412 Industrial Biochemistry: (3 Units) (L30: P0: T15) A short review of microbial physiology and genetics. Methods of extraction and purification of antibiotics. principles and applications. Primary and secondary metabolism.alcoholic. sickle cell anaemia. electron transport system and oxidative phosphorylation. Chemical thermodynamics. The public analyst in forensic practices. Theories of the mechanism of drug action. Introduction to general toxicology. antigenic determinants. A review of general metabolic pathways and application in industrial processes. Collection. . Components of the hepatic microsomal drug metabolizing system.amino acids . common cold. vitamins. Allergic disease and cancer immunology. Techniques for isolating parasitic protozoa from infected animals. Complement system and fixation. detection and use of monoclonal antibodies. Host-parasite interaction. perform experiments and produce reports (preferably at the end of second semester). Defence mechanism in parasitism. Antigen-antibody interaction Role of lymphoid tissues and thymus in immunoresponses. Students will be required to carry out literature survey on the topics. BCH 491 Advanced Biochemical Methods: (1 Unit) (L: P45: T0) Students will be made to familiarize themselves with operations of latest biochemical equipment in this course. Combining sites of antibodies. Biochemical mechanism of drug action against parasite. They will be taken round laboratories housing specialized equipment with the aim of exposing them to such equipment under the supervision of lecturers. Interferon. Immunodeficiency syndrome. methods of control of parasitic diseases. Students will be subjected to both seminar and oral examination on the project undertaken. Control of viral replication. Molecular basis of antibody diversity. Survey of structural properties of different classes of viruses. Immunological tolerance. Organisation of immunoglobulin genes. Parasites nutrient needs. Practical laboratory exercises designed by academic staff in areas not covered at lower levels will also be organized. BCH 499 Research Project: (6 Units) (L0: P270: T0) Independent research findings into selected areas/topics of interest to the academic staff. Production. BCH 417 Biochemistry of Parasites (2 Units) (L30: P0: T0) Classification of parasites. Viral multiplication mechanism. .Mechanisms and theory of antibody formation. Parasite biomembrane. Metabolism of biomolecules in parasites contrasted with that of the host.