US007250174B2(12) (54) United States Patent (10) Patent N0.: Lee et al. (45) Date of Patent: COSMETIC, PERSONAL CARE, CLEANING 4,994,414 A AGENT, AND NUTRITIONAL SUPPLEMENT COMPOSITIONS AND METHODS OF 5,034,216 A 5,074,916 A US 7,250,174 B2 Jul. 31, 2007 2/1991 Yamamoto et a1. MAKING AND USING SAME 7/1991 Barone et a1‘ 12/1991 Hench et al. 5,290,544 A * 3/1994 Shimono et al. (75) Inventors: Sean Lee, Karlsruhe (DE); Susanna Kessler’ Ergolding (DE); Oliver Forberich, Oberursel (DE); Claire BuchWar, Wiesbaden (DE); David C. Greenspan, Gainesviiie, FL (Us) 5380360 5,614,489 5,658,332 5,735,942 5,766,611 (73) Assignee: Schott AG, MainZ (DE) (*) (21) (22) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U-S-C- 154(1)) by 0 days- Man 27, 2001 (65) Prior Publication Data Us 2002/0086039 A1 Noguchi et 31' Mohammadi et al. Ducheyne et al. Litkowski et a1. Shimono etal. 5’827’882 A 10/1998 Yu et 31' 11/1998 Greenspan et al. 2/ 1999 Zhong ei ai~ 4/1999 Salonen et al. 4/1999 Rinaldi et al. 5,972,384 A 10/1999 Thut et al. 5,977,204 A 11/1999 Boyan et al. 5,990,380 A 11/1999 Marotta et al. 5,997,887 A 12/1999 Ha et al. 6,010,713 A 1/2000 Zhong et al. 6,086,374 A 7/2000 Litkowski et al. ]u1_ 4, 2002 Related U-S- Application Data (60) 1/ 1995 3/ 1997 8/1997 4/ 1998 6/1998 5,834,008 A 5,874,101 A 5,891,233 A 5,891,470 A Appl' NO‘: 09/818,466 Filed; A A A A A * 6,224,888 B1 * 5/2001 Vatter et a1. 6,517,863 B1* 2/2003 LaTorre et a1. Provisional application No. 60/ 197,162, ?led on Apr. 14, 2000, provisional application No. 60/192,216, ?led on Mar. 27, 2000. FOREIGN PATENT DOCUMENTS (51) Int. Cl. A61K 6/00 A61]; 9/00 A61K 25/34 A61K 8/00 (200601) (200601) (2006.01) (200691) A61K 8/18 (2006.01) (52) US. Cl. .................... .. (58) Field of Classi?cation Search .............. .. 424/400, EP W0 W0 W0 0 261 593 WO 97/27148 WO 98/11853 WO 98/46164 3/1988 7/1997 3/1998 10/1998 424/401; 424/400; 424/404; 424/64; 424/69; 424/70.1 (Continued) 424/401, 63, 64, 69, 59, 404 See application ?le for complete search history. (56) OTHER PUBLICATIONS References Cited Ogina, M et al., “Compositional dependence of the formation of US. PATENT DOCUMENTS calcium phosphate ?lms on bioglass”, Journal ofBiomedical mate rials Research, vol. 14, pp. 55-64, 1980. 3,922,155 A 3,981,736 A 11/1975 Broemer et a1. 9/1976 Broemer et a1. 4,120,730 A 4,171,544 A 10/1978 Trojer et al. 10/1979 Hench et a1. Primary ExamineriHumera N Sheikh 4,189,325 A 4,234,972 A 2/1980 Barrett et a1. 11/1980 Hench et a1. Frankel LLP 4,366,253 A 12/1982 Yagi 4,478,904 A 4,560,666 A 10/1984 Ducheyne et al. 12/1985 Yoshida et a1. (57) 4,604,097 A (74) Attorney, Agent, or FirmiKramer, Levin, Naftalis & ABSTRACT 8/1986 Graves et al. 4,652,534 A 4,698,318 A 3/1987 Kasuga 10/1987 Vogel et a1. 4,737,411 A 4,775,646 A 4,777,041 A 4/1988 Graves et al. 10/1988 Hench et a1. 10/1988 Mercado 4,783,429 A 4,786,555 A 11/1988 Shibuya et a1. 11/1988 Howard 4,814,165 A * 4,851,046 A (Continued) 3/1989 Berg et a1. 7/1989 Low et a1. 4,871,384 A 10/1989 Kasuga 4,965,071 A 10/1990 Kawan The present invention involves neW cosmetic, personal care, cleaning agent, biocidal agent, functional food, and nutri tional supplement compositions. These neW compositions incorporate bioactive glass into cosmetics, personal care items, cleaning agents, biocidal agents, functional foods, and nutritional supplements. The present invention also involves methods of making and methods of using such composi tions. 14 Claims, N0 Drawings US 7,250,174 B2 Page 2 FOREIGN PATENT DOCUMENTS W0 W0 W0 WO 98/46170 WO 99/13852 WO 99/16423 WO W0 W0 W0 W0 W0 W0 9937287 WO WO WO WO WO WO 99/37287 00/15167 00/42977 00/76486 01/03650 01/72145 10/1998 3/1999 4/1999 * 7/1999 7/1999 3/2000 7/2000 12/2000 1/2001 10/2001 Gross, U. et al., “The Response of Bone to Surface-Active Glasses/ Glass-Ceramics”, CRC Critical Reviews in Biocompatibility, vol. 4, No. 2, pp. 155-179, 1988. Gross, U. et al., “Surface Activities of Bioactive Glass, Aluminum Oxide, and Titanium in a Living Environment”, Annals New York Academy ofSciences, pp. 211-226. Niemi, L. et al., “In vivo behaviour of glasses in the SiO2-Na20 CaO-P205-Al203-B2-O3-system”, pp. 1-16. Hench, L., “Bioactive Glasses and Glass-Ceramics: A Perspective”, CRC Handbook ofBioactive Ceramics, vol. 1, pp. 7-23. Birchall, J ., The interrelationship between silicon and aluminum in OTHER PUBLICATIONS the biological effects of aluminum:, Silicon and Aluminum in Biology, pp. 50-67. Williams, D, Biocompatibility of Orthopedic Implants, chapter 6, Hench, L. et al., “Biological Applications of Bioactive Glasses”, Life Chemistry Reports, vol. 13, pp. 187-241, 1996. pp. 130-170, Sep. 1, 1982. Hulbert, S., “History of Bioceramics”, Ceramics International, vol. 8, pp. 131-140, 1982. Hench, L., et al., Biomaterials.‘ An Interfacial Approach, pp. 145 148, Academic Press, 1982. Hench, L. et al., “Surface-Active Biomaterials”, Science, vol. 226, Schepers, E. et al., “Bioactive Glass Particles of Narrow Size Range: A new material for the repair of bone defects”, Implant Dentistry, vol. 2, No. 3, pp. 151-156, 1993. European Search Report for EP 01922745.3 dated Mar. 10, 2006. pp. 630-636, Nov. 9, 1984. * cited by examiner US 7,250,174 B2 1 2 COSMETIC, PERSONAL CARE, CLEANING of bioactive glass for unrelated purposes such as orthopedic repair is described by Larry L. Hench and Jon K. West in AGENT, AND NUTRITIONAL SUPPLEMENT “Biological Applications of Bioactive Glasses” Life Chem istry Reports, 1996, Vol. 13, pp. 187-241, the contents of Which are incorporated herein by reference. COMPOSITIONS AND METHODS OF MAKING AND USING SAME RELATED APPLICATIONS DETAILED DESCRIPTION OF THE INVENTION This application claims priority from co-pending US. Provisional Application No. 60/192,216, ?led Mar. 27, 2000, co-pending US. Provisional Application No. 60/ 197, 162, ?led Apr. 14, 2000, co-pending US. application Ser. No. 09/456,196, ?led Dec. 7, 1999, and co-pending US. Bioactive glass is a sodium-calcium-phospho-silicate glass. As used herein, the term “bioactive glass” may refer to particulate melt-derived and/or sol-gel derived bioactive glass. In addition, the term “bioactive glass” may be used to application Ser. No. 09/456,195, ?led Dec. 7, 1999. The full disclosure of each of these applications is incorporated herein by reference. refer to an aqueous extract of particulate melt-derived an/or sol-gel derived bioactive glass. The present invention utiliZes bioactive glass preferably betWeen 40 and 96% by Weight of silicon dioxide oxide (SiO2), betWeen about 0 and 35% by Weight of sodium oxide (NazO), betWeen about 4 and 46% by Weight calcium oxide FIELD OF THE INVENTION The present invention involves neW cosmetic, personal care, cleaning agent, biocidal agent, functional food, and nutritional supplement compositions. These neW composi 20 typically silicon dioxide based compositions capable of tions incorporate bioactive glass into cosmetics, cleaning agents, personal care products, biocidal agents, functional foods and nutritional supplements. The present invention also involves methods of making and methods of using such (CaO), and betWeen about 1 and 15% by Weight phosphorus oxide (P205). As referred herein, bioactive glasses are forming hydroxycarbonate apatite (HCA). More preferably, 25 compositions. BACKGROUND OF THE INVENTION the glass includes betWeen 40 and 60% by Weight of silicon dioxide oxide (SiO2), betWeen about 5-30% by Weight of sodium oxide (Na2O), betWeen about 10 and 35% by Weight calcium oxide (CaO), and betWeen about 1 and 12% by Weight phosphorus oxide (P205). The oxides can be present as solid solutions or mixed oxides, or as mixtures of oxides. Preservatives are necessary and important ingredients that 30 ensure the stability and safety of di?cerent products. Many problems exist With respect to known preservatives. Many have unWanted effects on the products they are in or on the person or thing for Which the products are used. Many are relatively expensive and have no bene?cial e?cects besides preservation. Many, in fact, are not ef?cacious as preserva 35 Typically, bioactive glasses have the folloWing composi tion by Weight percentage: tives. Many have e?cects on the products’ texture or taste that make them undesirable. Better preservatives are needed. There has also been a great need for ingredients that can be used safely and bene?cially in products that have anti CaF2, B2O3, A1203, MgO and K20 may be included in the composition in addition to silicon, sodium, phosphorus and calcium oxides. The preferred range for B203 is betWeen 0 and 10% by Weight. The preferred range for K20 is betWeen 0 and 8% by Weight. The preferred range for MgO is betWeen 0 and 5% by Weight. 40 bacterial, antifungal, antiviral, ion releasing, anti-in?amma Component Wt. Percent tory and/or pH properties in the products themselves and/or $102 40490 on the person or thing for Which the product issued. Ingre CaO 445 dients that can express one or more of these properties are Na2O P205 Cal:2 B203 K20 MgO 0435 2416 0425 04 048 045 needed. 45 SUMMARY OF THE INVENTION Applicants have found that bioactive glass When used in a Wide variety of cosmetics provides exceptional qualities to the cosmetic including a bene?cial preservative e?‘ect. 50 A more prefered composition by Weight percentage for bioactive glass is as folloWs: Applicants also have found that bioactive glass preserves a variety of standard household and industrial cleaning agents. Further, certain bioactive glass compositions provide excel lent cleaning properties and greatly enhance the cleaning 55 properties of standard household and industrial cleaning agents. In addition, applicants have found that certain bio $102 active glass compositions are useful as a functional food and nutritional supplement or used in such. Moreover, certain bioactive glass compositions act as an excellent preservative for food. In addition, the compositions of this invention can be used herein “bioactive glass” is an inorganic glass material having an oxide of silicon as its major component. The use Wt. Percent 40468 CaO 5430 Na2O P205 10435 1412 60 The present invention includes formulations Which may comprise metal ions such as AgNO3, CuO, and ZnO, or other antimicrobial salts, including but not limited to, silver, formulated as disclosed herein to have enhanced and ben e?cial properties that include antibacterial, antiviral, anti fungal, ion-releasing, anti-in?ammatory and pH elfects. As Component 65 copper and Zinc ions. These metals may be in nitrate or acetate form. The preferred range for these salts is betWeen 0 and 15% by Weight. The present invention also includes formulations Which do not comprise metal ions. US 7,250,174 B2 3 4 The most preferred glass is Bioglass®TM (a trademark of University of Florida), Which has a composition including about 45% by Weight silicon dioxide, about 24.5% by When highly porous bioactive glass is used in place of or in addition to small particles of bioactive glass, the pore siZe is betWeen about 0 and 500 um, preferably betWeen about 10 Weight sodium oxide, about 6% by Weight phosphorus and 150 um, and more preferably, betWeen about 50 and 100 oxide, and about 24.5% by Weight calcium oxide. Another pm. The degree of porosity of the glass is betWeen about 0 and 85%, preferably betWeen about 30 and 80%, and more preferably betWeen about 40 and 60%. Porous bioactive glass can be prepared, for example, by incorporating a leachable substance into the bioactive glass composition, and leaching the substance out of the glass. Suitable leach preferred material is hydroxyapatite. Another preferred material for several applications are the porous sol-gel glasses. Particulate, non-interlinked bioactive glass is preferred for many embodiments of the present invention. That is, the glass is in the form of small, discrete particles, rather than a able substances are Well knoWn to those of skill in the art, and include, for example, sodium chloride and other Water soluble salts. The particle siZe of the leachable substance is roughly the siZe of the resulting pore. The relative amount and siZe of the leachable substance gives rise to the degree of porosity. Also, as described herein, porosity can be fused matrix of particles or a mesh or fabric (Woven or non-Woven) of glass ?bers. Note that under some conditions the discrete particles of the present invention may tend to cling together because of electrostatic or other forces but are still considered to be non-interlinked. Preferably the particle siZe is less than about 90 microns; more preferably, less than about 20 microns; even more preferably, less than about 5 microns, and most preferably, less than about 2 microns, as measured by SEM or laser light scattering techniques, achieved using sintering and/or by controlling the treatment cycle of glass gels to control the pores and interpores of the material. 20 In addition, anti-microbial and anti-in?ammatory compo although different uses may advantageously use different sitions derived from aqueous extracts of bioactive glass can particle siZes. be formed by placing bioactive glass in an aqueous solution, alloWing the glass to dissolve over a suitable period of time, The preferred particle siZe range for the bioactive glass is site and use dependent. Particle siZes less than about 1000 microns and greater than about 2 microns can also be used. Particles of such a small siZe range generally provide for the for example, a Week or more, and ?ltering out the dissolved 25 advantages of the present invention Without eliciting unde sirable immune responses. Without being bound to a particular theory, it is believed that there is a complex relationship betWeen the type of ion being released from the glass, the amount of that ion, the rate at Which release occurs, the pH of the surrounding environ ment, and the resulting anti-microbial or anti-in?ammatory response. This effect is observed With respect to the particles of bioactive glass themselves and also in the aqueous 30 35 provide melt-derived glass, sol-gel derived glass and sin tered glass particles. The sintered particles may be in sol-gel derived, unreacted, or pre-reacted melt-derived form. The glass composition is preferably melt-derived. Melt derived glass is generally prepared by mixing grains of be used. 40 oxides or carbonates, melting and homogenizing the mix tures at high temperatures, typically betWeen about 1250 and 45 produce a small particulate material. In each preparation, it is preferred to use reagent grade glass, especially When the glass is used to prepare materials Which ultimately may be administered topically. Bioactive 50 grinding process described previously in Us. Pat. No. 5,204,106, the disclosure of Which is incorporated herein by reference. Where particular particle siZe ranges are desired, sifting may be used to obtain such particles. For optimum 14000 C. The molten glass can be ?itted and milled to glass particles may be prepared using the melt-derived and bacteria may be found in and on the skin. These antimicro bial properties are enhanced in an aqueous environment. While not being bound by a speci?c mechanism of action, it is believed that this action is a result, inter alia, of the greatly increased bioactivity of the small particulates, Which reduction, or prevention of microbes, including but not limited to bacteria, viruses, and fungi Would be advanta geous, for example, in cosmetic formulations, cleaning agent formulations, functional foods and as a preservative for foods. The glass composition can be prepared in several Ways to solutions derived from the glass particles. Accordingly, in the compositions and uses described beloW, particulate and/ or bioactive glass solutions derived from the particles may Large particles of bioactive glass do not have appreciable antimicrobial properties. HoWever, small particles of bioac tive glass and highly porous bioactive glass do have appre ciable antimicrobial properties. Bioactive glass has bacteri cidal properties and is effective against, for example, Staph. aureus, Staph. epidermidis, and various streptococci. These glass particles. The solvent can also be evaporated to pro vide a solid material With anti-microbial properties. These compositions can be used in situations Where elimination, leads to an increased pH of the surrounding environment. sterility, glass particles may be ultrasonically cleaned, pack The combined properties of being both broadly bactericidal aged in syringes and steriliZed With gamma radiation. The particulate biologically active material used in the present invention may be prepared according to the methods While at the same time maintaining tissue biocompatibility make a variety of formulations comprising small particles of bioactive glass resistant to microbial contamination and especially suitable for formulations Which Will contact the skin. The antimicrobial action increases With decreasing par ticle siZe. The preferred particle siZe depends, in part, on the expected microbial challenge and the desired purity of the 55 of the art such as taught in Us. Pat. Nos. 4,159,358; 4,234,972; 4,103,002; 4,189,325; 134,171,544; 4,775,646; 4,857,046 and 5,074,916. For example, the raW materials (e.g., SiO2, CaO, Na2O and PZOS) are mixed in a Nal gene®TM plastic container on a ball mill for four hours. The 60 mix is then melted in a platinum crucible at 13500 C. and formulation comprising bioactive glass For example, for mulations having bioactive glass particles averaging 20 homogenized for 24 hours. The molten glass is poured into microns ordinarily is suf?cient. HoWever, for a longer last ing preservative effect or to maintain a higher degree of purity, particles averaging less than ?ve microns as mea sured by SEM or laser light scattering techniques may be used. tively, ribbons may be prepared by pouring the glass over distilled, deioniZed Water to produce a glass frit. Altema moving rollers. The frit or ribbons may be ground, for 65 example, by one of several means. In one method the frit or ribbons are ground in a mortar and pestle and passed through ASTM sieves to produce the required particle siZe range. Near-equilibrium dry SiO2 ing in place of or in addition to drying under dry conditions provides for much larger average pore siZe in the ?nal composition at a given level of SiO2 In addition near equilibrium drying results in a higher rate of resorption as solution. Thus. near-equilibrium drying is drying under 20 equilibrium drying may be drying under the conditions near For example. one can drastically alter 59 reactions can take place). aluminum. iron and potassium also can be used. Such sol-gel glasses are also more homogeneous than other sol-gel glasses and calcium is distributed uni melt-derived glass or porous melt derived glass. While not being bound to any particular theory. PoWders can be made to spherical form and from submicron to a feW hundred microns. calcium and phosphate anions. magnesium. SSA ranging from 50-400 m2/g. i. the technique can be used to prepare frit.. The loWing composition by Weight percentage: Component monolith can be formed to complex shapes such as various implants. increas ing the sealing of the drying chamber during drying typically results in an increase in relative humidity and pore diameter. su?icient to yield a bioactive glass . increased pressure is used instead of near-equilibrium drying to achieve larger pore siZe and greater resorbability. grams (or other liquids such as methanol. triethylphosphate (TEP). acetone. mechanisms are different from those associated With non sol-gel-derived bioactive glass. Sol-gel librium drying technique provides gels having excellent derived glasses produced this Way are knoWn to have an resorbability even When high amounts of silicon dioxide are initial high speci?c surface area (SSA) compared With either included. for example. For example. With Water drying. Alkoxides of the line for Water as illustrated in conventional phase dia calcium. Sol-gel processing Which uses a near-equilibrium drying step yields larger pore siZe in the ?nal product and permits development of HCA very rapidly for both high and loW silicon dioxide content gels. aerogels may be used. ribbons.250. it is believed that the near-equilibrium drying step reduces cap A more prefered composition for sol-gel-derived bioac tive glasses comprises the folloWing composition by Weight percentage: useful. Other appropriate ingredi 25 relative humidity (from environmental humidity to 98%). monoliths. When an aerogel is used. By manipulating the sealing of the designed drying chamber to adjust the extent of the drying condition aWay from the equilibrium line and 5435 P205 aqueous solutions because of the high SSA (i. 24. For example. poWders. such as those referred to above.) ?ring to produce a glass. Mater. J. Frit can be ground to very broad ranges of particle siZe Typically. This permits much better control of the ?nal product eg resorbability. Percent ents Will also be apparent to those of ordinary skill in the art. Kokubo. homo geneity and physical structure. a reaction mixture including tetraethoxysi lane (TEOS). In contrast. The near equilibrium drying technique also provides for more homogeneous gels Which can be heated to higher tempera tures While retaining large pore diameter. treating tooth hypersensitivity as illary force inside the pore structure of the gel Which results in large pore siZe. When using liquids other than the concentration of calcium and phosphate anions is increased to the saturation limit for HAp. Zirconium. Indeed. coatings. drug delivery. and the temperature 30 pore siZe of resultant bioactive glass. there is a tremendous amount of surface area Where glass/solution that more than 50% of sol-gel material made in this manner the conditions near the tWo phase boundaries in the phase diagram at a temperature and pressure su?icient to yield a bioactive glass With large pore structure. Indeed. For example. a pore structure 49472 CaO The sol-gel-derived bioactive glass readily reacts With compared to traditionally prepared sol-gel bioactive glass materials. do not resorb at all by eight Weeks. The netWorks includes voids Which become pores . it has been suggested that glasses including more Wt. Such compositions are Wt. Comparable prior 4555 melt derived bioactive glasses. burn healing CaO 542 P205 1412 and Wound healing. For example. near at Which the drying is conducted. Bioactive glass may be derived using a drying step. Near-equilibrium drying temperature can also be varied. sol-gel-derived bioactive glasses have the fol such as from about 2 pm up to 1 mm for any purpose. T. a mineralogical. the sol-gel-derived bioactive glass begins to react. HAp-rich layer Will form on the surfaces that comprise the sol-gel-derived bioactive glass. Weaves and composites.. ?bers. When this material comes into contact With an aqueous solution.174 B2 5 Alternatively. and surrounding surfaces (i. the dissolution sol-gel bioactive glasses. The result ing material contains nanometer-sized purosity and has a formly. the near-equi folloWed by hydrolysis. the duration of near-equilibrium drying. releasing soluble silica. Which Component may include near-equilibrium drying. SBF (Simulated Body Fluid.. hard and soft human tissues). When immersed in an aqueous than 55% silicon dioxide are not bioactive. ethanol. benZene and so on). Percent 60 SiO2 49490 Well as the remineraliZation of tooth structure. Gels are netWorks of small colloid particles.e. gelation. et al. one may obtain a faster drying or increase the pore siZe range of the gel to a large extent.e. these compositions form HCA more rapidly than other gels When exposed to 35 Water. Res. in bone repair and other orthopedic applications. and loW temperature (around 200-900° C. In addition. Biomed.. for example. mats. Sol-gel derived glass is generally prepared by synthesizing an inorganic network by mixing metal alkoxides in solution. liquid (CO2. 721-34.US 7. A sol-gel process is any process that includes the use of a sol-gel in the preparation of bioactive glass. titanium. and calcium nitrate can be used to make sol-gel bioactive glasses..e. 1990) or physiological ?uids. sol-gel com positions derived Without using near-equilibrium drying techniques are not able to provide adequate resorbability at higher levels of silicon dioxide. For example. in-vivo testing of one has shoWn resorbed at eight Weeks. the frit or ribbons may be ground using a ball-milling or jet milling process. Once 15 As used herein. The sol-gel derived glass This drying technique can be used to prepare all types of does not contain sodium. skin. due to the liquid tension. make-up compounds and tinctures. particulate bioactive glass having an average particle siZe Bioactive glass and/or sol-gel-derived bioactive glass less than 10 microns. nails and teeth. Accord may be effective at absorbing and scattering visible and UV light. On the other hand. and therapeutic release of inorganic ions. hoWever. anti-in?ammatory behavior.5% of the Weight and pressure difference. and several examples of cosmetic formulations that can be used to include bioactive glass 45 microbial contamination. the sol-gel-derived bioactive glass is effective at scattering UV light in the UVA and UVB regions of the solar spectrum and provides a soft for example.. bioactive glass may be included in cosmetic formulations to minimiZe protic solvent. make-up compounds. body ?uids) to A goal of the present invention is to produce cosmetic elicit biological effects such as anti-microbial/antibacterial 40 behavior. after unsealing the package. making these materials attractive for soft focus and sun-screening applications. With out having to add skin-irritating cytotoxic and possibly allergen producing chemical preservatives to the prepara tion. functional foods. Upper limits of 7% of the Weight or 5% of the Weight are preferred for some formulations. the formulations. In one embodiment the cosmetic formulation comprises a inside the pore structure to evaporate under the condition of near equilibrium at a range of temperatures. 0-10% B203. HoWever. bacteria. Thus. the sol-gel-derived bioactive glass reacts With aqueous solutions to form a solution that becomes concen . lipsticks. the pressure preparations. an additional nurturing effect may be achieved through the antimicrobial and in?ammation-inhib iting effect of bioactive glass. Bioactive glass.e.01% of the Weight. human perspiration. The preservative Which contains bioactive glass may be added to or included in cosmetic formulations. in contrast to presently available cos metics.174 B2 7 8 and pore channels in the ?nal glass composition. sol-gel derived bioactive glass and/or aqueous extracts of bioactive glass may be incorporated into various cosmetic. This keeps liquid vapor pressure inside the channels and pores at high heating conditions Which resists the shrinkage and collapse 20 10-30% CaO. min eralogical ?lm forming. 10-35% Na2O. itching. y is liquid tension. In one embodiment the cosmetic formulation comprises Cosmetic formulations in accordance With the present invention can be Well preserved using bioactive glass. AP. Will pull the netWork tight enabling pore collapse and gel shrinkage as liquid evaporates. Pre ferred cosmetic preparations are especially creams. fungi and/or mold may contaminate the cosmetics. 0-8% K20. for example. humidity. cosmetic and/ or pharmaceutical from the skin in such a Way that skin Wrinkles become less visible to the human eye. espe cially 0. This HCA layer can desensitiZe teeth. cleaning agent. The sol-gel-derived bioactive glass 65 focusing effect. 25 Cosmetics General The present invention provides novel cosmetics compo sitions comprising bioactive glass. 0 is contact angle and r is the radius of pores and pore channels. 2-8% P205. The anti-in?ammatory effects of bioactive glass make it particularly useful in skin care formulations by promoting reductions in irritation. skin irritation for the cosmetic user. formulations Which. These effects are considered advantageous for many cosmetic applications. of the gel structure and results in large pore siZes. and 0-5% MgO.250. While current manufac turing processes generally control microbial contamination When the products are in sealed containers. various antibacterial agents are added to the cosmetics to minimiZe this process.US 7. Further. 0-25% CaF2. more especially up to 50%. and thus effective at scattering visible and UV light. UV screening. In another embodiment particulate bioactive glass having an average particle siZe less than 5 microns. Often. or alternatively. lotions. In another embodiment the present invention provides a preservative Which itself contains bioactive glass. protect skin and modify hair texture. In another embodiment the cosmetic formu lation contains bioactive glass Which has components Within the folloWing ranges on a % Weight basis: 40-60% SiO2. 55 is extremely porous. The cosmetic compositions can and/or sol-gel-derived bioactive glass Within a cosmetic product are described herein. LoWer limits are 0. lipsticks. and preferably less than 2 microns is used. fungi and/or mold. It is believed that near-equilibrium drying alloWs the liquid 1% of the Weight are especially preferred as the loWest effective amounts. including contamination by bac teria. It is believed that the moisture of the near-equilibrium drying step enhances the reaction at the neck betWeen tWo particles in the netWork and the strength of the neck and “back bone” of the gel structure Which reduces shrinkage of the drying structure and ultimately results in gels With large pores. bioac tive glass can be added to virtually any cosmetic presently available to improve its resistance to contamination. The scatter of visible light is important for soft focus cosmetic products. or 40%. A cosmetic formulation in accordance With the present invention may contain an amount of bioactive glass up to 95% of the total Weight of the cosmetic formulation. In special cases it might be desirable to add the preser vative in accordance With the present invention to prepara tions Which have been preserved using standard preserva tives in order to achieve synergetic effects. exhibit an ability to Withstand microbial contami nation Without creating negative effects such as skin irrita tion. Bioactive glass has the ability to react With aqueous solutions (i. creams. 50 nails. espe cially up to 70%. During drying. The perishable In one embodiment cosmetic products comprise sol-gel derived bioactive glass. the cosmetic may be liquid based. In one embodiment of the present invention. These antibacte rial agents. lotions and salves since the micro biocidal effect of bioactive glass is further enhanced by the moisture contained in these preparations. Bioactive glass forms a hydroxy carbonate layer (HCA) include the aqueous extracts of bioactive glass and/or par on protein-containing surfaces such as hair. Cosmetic formulations may include. nutri tional supplements and other products as described beloW. goods may be. often create negative effects such as 30 35 redness and rashes.1% of the Weight. and even more preferably up to 30% of the Weight of the cosmetic formulation. In one embodiment the invention provides bioactive glass for use as a preservative of perishable goods. Whereby 0. Furthermore. harden/thicken ticles of bioactive glass. difference betWeen the different siZe of pores and channels is: APIZY cos 0/r Whereby 3% of the Weight is especially preferred in some Where. other than liquid based. Which are intended to scatter light 60 ingly. the scatter of UV light is important for sunscreen products. Further. derived from particulate bioactive glass. An “effective antimicrobial amount of derived bioactive glass may be formulated in liquids. pastes. gels or creams that are anhydrous. the formulation may contain aqueous cosmetic ingredients. mixing. Preferably. or even vigorous agitation. An “effective antimicro bial amount” of bioactive glass may also refer to a combi nation of particulate bioactive glass and aqueous extract of With aqueous solutions. and ment the bioactive glass may be particulate. This solution could then be ?ltered. Thus. The amount and particle siZe of bioactive glass to include in a cosmetic formulation Will vary depending on the desired length and degree of purity as Well as the anticipated microbial challenge. In another embodiment bioactive glass and/or sol-gel derived bioactive glass are mixed With an anhydrous liquid. Maintaining this pH level With bioactive glass in an aqueous suspension.US 7. Other methods or combinations of methods of blending. Bioactive glass and sol-gel derived bioactive glass exhibit bioactive glass is particularly useful in formulations Which require topical application. Suf?cient agitation should be provided to achieve relative homogene Water permeable). for example. General mixing and blending may be achieved. In addition. similar to the dispensing system used for an epoxy). increasing the pH value. 30 contamination. yet disappears once applied to the body. HAp-rich layer on the to surrounding human tissue. paste. paste. Bioactive glass may be added to or included in virtually any knoWn cosmetic formulation. it can form a mineralogical. combining and/or emulsifying may be humidity. In this instance. phosphate anions and soluble silica. bioactive glass is easier to homo geneously mix than other common inorganic poWders. ity. the desirable characteristics associated With bioactive glass and/or sol-gel-derived bio active glass are achieved by utiliZing an aqueous extract of It has been unexpectedly discovered that for many cos metic base formulations. Within one vessel. past. for example. the bioactive glass remains un-reacted While immersed in the anhydrous liquid. antibiotics may also be added to cosmetic formulations. for example. homogeneous cream consistency. Which is consistent With the hiding skin Wrinkles. since there Would be no solid bioactive glass or embodiment the bioactive glass may be an aqueous solution sol-gel-derived bioactive glass available for reaction. In another then added to cosmetic formulations to develop cosmetic products in accordance With the present invention. it is believed could act as a skin-tightening agent that Would further aid in that the bioactive glass has an af?nity for oils as Well as Water and protenaceous matter. Without being bound to any mechanism. When this solution becomes saturated. In this embodiment. An effec tive antimicrobial amount of the bioactive glass is added to or included in a cosmetic formulation. bioactive glass mixed With Water unexpectedly forms a cream.174 B2 10 Applicants have unexpectedly discovered that a combi nation of bioactive glass With standard skin creams give the skin a pleasant-non-oily feeling and look When compared trated in calcium. is di?icult as the glass Will continuously react in as yet to be developed cosmetic formulation. Applicants have unexpectedly discovered that bioactive solution. The cream resulting from mixing bioactive glass With either oil or Water possesses a consistent homogenized texture par ticularly suitable for cosmetic formulations.. utiliZed. This is to be contrasted With the effect of adding a standard bulfer. bioactive glass” also may refer to a suf?cient amount of an aqueous extract of bioactive glass to effectively prevent or control microbial contamination.e. 45 In yet another embodiment. Bioactive glass and sol-gel-derived bioactive glass react cosmetic compositions comprising bioactive glass. Which do not maintain . HoWever. Applicants anticipate as Well that bioactive glass Will be suitable for inclusion in any skin after being applied to the body. but Water-soluble (or 25 humidity. With standard mixing devices. anti In one embodiment. but are inert When immersed in derived from bioactive glass. the sol-gel-derived bioactive glass is expected to be effective in soft focus products because it is effective at scattering visible light. phosphate anions and soluble silica. Bioactive glass may be added to or included in cosmetic formulated in an anhydrous liquid. and the precipitation of the mineralogical layer With the same cream applied Without the added bioactive glass. techniques or combina tions of techniques such as general mixing With sloW medium. The bioactive glass and/or sol-gel-derived bioactive glass may be could be bioactive glass to effectively prevent or control microbial formulations using. hoWever. LikeWise. cream or gel may be contained Within the second vessel. moderate. for example. gel or cream. dispersing. In still another In many cosmetic applications it is desired that the product have pH value of betWeen 5 and 8. and then become reactive (active) When applied onto the human body. such as HCL based bulfers to the same suspension. anti microbial amount of bioactive glass” refers to a suf?cient amount of bioactive glass having an appropriate particle siZe 20 anhydrous liquids. The addition of antibiotics to cosmetic products Which include bioactive glass is suitable as an effective treatment for form a smooth. With an impeller. such as titanium dioxide and Zinc oxide poWder. Thus oily/fatty skin. ered that as little as 1% citric acid can effectively bulfer 65 bioactive glass toWard more neutral pH values over a long period in an aqueous suspension. bioactive glass and/or sol-gel-derived bioactive glass for cosmetic products are used in a dispens ing system containing tWo separate vessels (i. the dif?culty lies in formulating the Methods of Making cosmetic products in such a Way that the bioactive glass The present invention also provides a method of making and/or sol-gel-derived bioactive glass remain unreacted (passive) While packaged. The bioactive glass and/or sol-gel-derived bioactive glass may be reacted With an 50 aqueous solution until the solution became saturated With calcium. many desirable characteristics that Would improve cosmetic products. mixing and agitation Will avoid excessive aeration and Will have a loW sheer rate. Thus. The anhydrous liquid. In one embodi embodiment the bioactive glass may be a combination of particulate bioactive glass and an aqueous solution derived 55 60 from bioactive glass. bioactive glass and/or sol-gel to effectively prevent or control microbial contamination. thus alloWing the bioactive glass to react With perspiration.250. and/or other aqueous-containing bodily liquids. and/or other aqueous-containing body liquids. cream or gel 35 paste cream or gel that evaporated or is metaboliZed into the 40 ?oculants may be used to keep the particles from clumping cosmetic package. buffered to an appropriate pH. Applicants have discov glass mixed With oil forms a cream. unexpected effect observed by Which bioactive glass and oil It should also be noted that in addition to bioactive glass. While an aqueous liquid. Agitation may be achieved. cream or gel protects the bioactive glass While in the together. but Would be activated When applied to the human body and alloWed to react With perspiration. An “effective. paste. non-irritating cosmetic formulations. including sol-gel derived bioactive glass may be combined With anyhydrous cosmetic ingredients to created stable. for example. for example colorants and Tergitol NP-9 Coco Hydroxy Sultaine fragrances. Bioactive glass is especially useful in an aqueous containing formulation When the formulation is TABLE II RaW Materials Combined With Sol-Gel-Derived Bioactive Glass appropriately buffered to ensure that the pH remains near neutral and When the bioactive glass is coated With a RaW Material hydrophobic material that prevents the glass from reacting PPG l0 Cetyl ether PEG7 Glyceryl Cocoate d-Limonene Oleth-3 Stepanquat ML Ammonium Lauryl Sulfate Incromectant LQ Dermol M5 While in formulation. and packaged in small packets or caches for single use cosmetic products for skin. hair or nail applica tions. citric acid is one preferred method of buffering aqueous based solutions With bioactive glass. Crodesta SL-4O POE2O Sorbitan monooleate Propylene Glycol The folloWing raW materials listed in Table 1 Were mixed Ethanol Na Laureth-2 Sulfate Sorbitan Isostearate With bioactive glass and produced stable compositions. TABLE I Glycerin 20 Procetyl AWS Crodafos SG RaW Materials Combined With Bioactive Glass Glycerox 767 Cocamide DEA RaW Material Incromectant AQ Promyristyl PM-3 Jojoba Oil Incromectant AQ 25 Foamtaine CABG (45%) Promyristyl PM-3 Dermol DPG — 2B Abil EM-90 Dermol DPG-2B Transutol CG Transcutol CG Octyl Methoxycinnamate Crodafos N3N Triethanolamine Menthyl Anthranilate Octyl Methoxycinnamate Crodafos N3N Triethanolamine 30 Mineral Oil Incrodet TD7C Menthyl Anthranilate Mineral Oil Incrodet TD7C Polyderm PPI SiWI PEG2 Oleamine Crodafos CAP Plantaren APB Polyderm PPI SiWI PEG2 Oleamine Crodafos CAP Plantaren APB 35 Polyderm PPI SiWS Finsolv TN Crodasinic O Dermol B-246 GE 1202 Crovol A-4O Crovol A-7O GE SF 96 350 cps Polyderm PPI SiWS Finsolv TN Crodasinic O Dermol B-246 GE 1202 Crovol A-4O Crovol A-7O 40 Probutyl l4 GE SF 96 (350 cps) Probutyl l4 Foamtaine CABG Dermol MS PPG l0 Cetyl ether PEG 7 Glyceryl Cocoate d-Limonene Oleth-3 Stepanquat ML Ammonium Lauryl Sulfate Incromectant LQ Tergitol NP-9 Coco Hydroxy Sultaine 45 Bioactive glass. but not limited to the Abil EM-90 following: Ethanol The folloWing raW materials listed in Table 2 Were mixed With sol-gel-derived bioactive glass and produced stable compositions.174 B2 11 12 pH levels for suitable periods of time. 65 Isopropanol n-propanol lauryl alcohol . The dry form may be a poWder. but not limited to the following: Glycerin Procetyl AWS Crodafos SG Glycerox 767 Cocamide DEA 60 Glycerin Propylene Glycol Butylene Glycol Hexylene Glycol 2-methyl propane diol Jojoba Oil Cosmetically acceptable Alcohols — including. In another embodiment the bioactive glass and/ or sol-gel derived bioactive glass can be formulated into a dry form incorporating other ingredients. TABLE III Crodesta SL-40*** POE2O Sorbitan monooleate Anhydrous Cosmetic Ingredients Combined With Bioactive Glass Propylene Glycol Ethanol Na Laureth-2 Sulfate Sorbitan Isostearate 55 Cosmetically acceptable Glycols — including.US 7.250. Thus. A list of 50 exemplary anhydrous ingredients is provided in Table III. but not limited to the HeXylene Glycol following: 2-methyl propane diol Isopropyl Myristate folloWing: Cosmetically acceptable Alcohols — including.250. but not limited to the folloWing: Fatty amine salts Zonyls Quaternary nitrogen salts Cosmetically acceptable mineral. Polyalkenes Polyoxethylenes PolyoXypropylenes Polyamides Polyesters Polyurethanes TABLE IV Anhydrous and Hydrous Ingredients Which May Be Used in a TWo Compartment Dispensing System Cosmetically acceptable Glycols — including. non-irritating cosmetic formu Fatty acid diethanolamides Fatty acid monoethanolamides lations. but not limited to the Isopropyl Palmitate Jojoba Oil Glyceryl tri caprate/caprylate Ethanol Isopropanol n-propanol Propylene glycol di caprate/caprylate lauryl alcohol oleyl alcohol Sorbitan Esters Diesters of diacids Cosmetically acceptable Ethoxylated Materials — including. but not limited to the folloWing: may be combined With anyhydrous and hydrous cosmetic ingredients to created stable. but not limited to the Ethoxylated PropoXylates folloWing: Cosmetically acceptable anhydrous ionic surfactants — including. but not limited to the Cellulosics and derivatives folloWing: Polyacrylics Polymethacrylics PolysiloXanes Cosmetically acceptable copolymers Glycerin Propylene Glycol Butylene Glycol 65 Cosmetically acceptable cosmetic formulation bases — including. but not limited to the folloWing: Esters of PropoXylated Fatty Alcohols Ethoxylated PropoXylates Cosmetically acceptable anhydrous ionic surfactants — including. but not limited to the folloWing: Isobutane HFC. but not limited to the folloWing: Isopropyl Myristate Ethoxylated Fatty Alcohols Ethoxylated Fatty Acids Isopropyl Palmitate Jojoba Oil Glyceryl tri caprate/caprylate Ethoxylated Sorbitan Esters Ethoxylated Glycerides Cosmetically acceptable PropoXylated Materials — including. but not limited to the folloWing: Cosmetically acceptable Esters — including. including sol-gel derived bioactive glass 50 Cosmetically acceptable amides — including.174 B2 13 14 TABLE III-continued TABLE IV-continued Anhydrous Cosmetic Ingredients Combined With Bioactive Glass Anhydrous and Hydrous Ingredients Which May Be Used in a TWo Compartment Dispensing System oleyl alcohol Cosmetically acceptable Esters — including. but not limited to the folloWing: Dimethicone Simethicone Cyclomethicone Propane 45 Butane Pentane Dimethicone ethoXylates and propoXylates Cosmetically acceptable ?uorocarbons and derivatives — including. but not limited to the folloWing: 20 PropoXylated Fatty Alcohols PropoXylated Fatty Acids Propylene glycol di caprate/caprylate Sorbitan Esters Diesters of diacids Cosmetically acceptable Ethoxylated Materials — including. CFC. Cosmetically acceptable silicones including. but not limited to the folloWing: Fluorcarbon alcohols Cosmetically acceptable aerosol propellants — including. but not limited to the folloWing: provided in Table IV. but not limited to the folloWing: Sulfaters Carboxylates Fatty amine salts 30 PropoXylated Fatty Alcohols PropoXylated Fatty Acids Quaternary nitrogen salts Cosmetically acceptable mineral. HCFC Zonyls Fluorcarbon alcohols Bioactive glass. vegetable and animal derived oils and 40 fats. Anhydrous and hydrous cosmetic ingredients may be used in a two-compartment dispensing system. Cosmetically acceptable silicones including.US 7. but not limited to the folloWing: Dimethicone Simethicone 35 Phosphate esters Cyclomethicone Sulfaters Dimethicone ethoXylates and propoXylates CarboXylates Cosmetically acceptable ?uorocarbons and derivatives — including. vegetable and animal derived oils and Esters of PropoXylated Fatty Alcohols fats. but not limited to the folloWing: 25 Ethoxylated Fatty Alcohols Ethoxylated Fatty Acids Ethoxylated Sorbitan Esters Ethoxylated Glycerides Phosphate esters Cosmetically acceptable PropoXylated Materials — including. but . A list of exemplary anhydrous and hydrous cosmetic ingredients is Fatty acid dimethylamnopropylamides 55 Cosmetically acceptable Polymers — including. anti-wrinkle. nursing pads (for bras). mouth wash and mouth rinse products. disodium EDTA. In addition. cetyl hydroxyethylcellulose.250. Hawaiian Tropic. Also. The present invention provides for novel formulations of 65 bioactive glass can be doped with various metals. Coppertone. isopropyl palmitate.174 B2 15 16 toning and exfoliating products and makeup removal prod ucts. citric acid. and contact lens treatment products. such as the products marketed under the brand names A-FIL. and products produced by high-end and generic manufacturers. sorbic acid. PEG-20 methyl glucose sesquistearate. glyceryl stearate. caprylic/capric triglyceride. polysorbate 20. maxipad and pantiliner products. bisabolol. such as the products marketed under the brand names Bain de Soleil. freckle coating products. hyd_ro crosspolymer. eucalyp tus oil. Good Sense. foot care products. triglyceride. sorbitol. DEA-cetyl phosphate. The present invention includes novel formulations which incorporate bioactive glass into various brands of pigmen 20 tation products. imidazo lidinyl urea. ethoxydiglycol. diaper. butylparaben. Sun Care Products The present invention includes novel formulations which incorporate bioactive glass into various brands of sun care products. ceteth-lO. and/or manganese. isoceteth-20. epilatory and hair bleaching products in creme. depilatory. propylpa Aerosol propellant gases One aspect of the present invention will be more clearly understood with reference to the following non-limiting examples of cosmetic and personal care products and for raben. but not limited to the following: methyl gluceth-20. disodium EDTA. Such products. sodium metabisul?te. wax and powder forms. Alba Botanica. PPG-l trideceth-6. xanthan gum and various vitamin. emulsifying wax. stearic 55 pigmentation products by incorporating bioactive glass into a combination of any of the above-listed ingredients. including but not limited to iron. facial moisturizing. glycereth-7 triacetate. but not limited to the Generally. dimethicone. polysorbate 80. silicone. steareth-2. Fruit TABLE V of the Earth. anti-itch products. shoulder pads. antiseptic. mulations which are suitable for use with bioactive glass. liquid and gel form and bath salt products. PEG-7 glyceryl cocoate. triethanolaminel and witch hazel. octyl methoxycinamate. carbamate/acrylate copolymer. but not limited to the following: Ethoxydiglycol 35 following: ate. pigmentation products comprise the active ingredient dehydroxyacetone (DHA). sorbitan isostearate. dicaprylate/dica prate. panthenol. acid. fragrance. acne prevention and treatment products. antiper spirant and deodorant products in powder. cobalt. Banana Boat. Ambrelle. butylene glycol. combinations may used to create stable. polydimethylsiloxane-PPG ether/IPDI copolymer. polysorbate 60. antibiotic and ?rst aid products. Categories of Cosmetics and Personal Care Health Products The present invention will produce novel formulations of a variety of cosmetic and personal care products including 60 but not limited to: pigmentation and sun care products. dipropylene glycol. shampoo and hair detangling prod ucts. Pigmentation products may also include one or more of 40 following: polyquatemium-37. glycerin. wig and toupee powder Bioactive glass. iodopropyl butylcarbam the following: isoceteth-3 acetate. benzyl alcohol. facial cleansing. sodium PCA. to produce a desired pigmentation. C12-15 alcohol benzoate. steareth-20. Aloe Vera 80. Cosmetically acceptable Alcohols — including. dihydroxyacetone. octyl palmitate. anti-bacterial. aftershave and shaving lotion prod ucts. mineral. baby powder and body powder and diaper rash products. powder and soap TABLE IV-continued Anhydrous and Hydrous Ingredients Which May Be Used in a Two Compartment Dispensing System not limited to the following: Emulsifying Waxes Lubrajels Zilgels Jojoba Glaze Absorption Bases forms. PPG-20 methyl glucose ether distearate. phenoxy ethanol. fruit and plant extracts. shaving products in creme. Kiss My Face. Acetone Methyl Ethyl Ketone 45 n-alkanes branched alkanes caprylic/capric. aloe gel. DMDM hydantoin. propylene glycol. including sol-gel derived bioactive glass also may be combined with cosmetic ingredients which products. tampon. petrolatum. PEG-100 stear Cosmetically acceptable silicones — including. hand lotion and body lotion products. Evaporating Ingredients Neutrogena. ceteth-2. non-irritating cos Pigmentation Products metic formulations. makeup products. but not limited to the following: prise water. stearyl alcohol. tocopheryl acetate. chloro ?uoro carbons. melanin. eye drop evaporate shortly after being applied to the skin. bioactive glass itself can act as a pigment. roll-on. Cyclomethicone Cosmetically acceptable Aliphatic compounds — including. aerosol and stick form. toothpaste products. but not limited to the following: 30 Ethyl acetate Butyl acetate Cosmetically acceptable Ethoxylated Materials — including. ethylparaben. gel. unasaponifables. dimethyl isosorbide. ceteareth-20. A list of exemplary cosmetic ingredients which may evaporate after being applied to the skin is provided in Table V. bath and shower soap in bar. acrylates/Cl0-30 alkyl acrylate ate. hair gel and hair spray products. lanolin. methylparaben. cocoa butter. caramel.US 7. baby wipe and hand wipe. Bain . cetyl alcohol. magnesium aluminum silicate. 50 ?uoro carbons and hydro chloro ?uoro carbons — including. creme. diazolidinyl urea. Permethyls Aerosol propellant gases Cosmetically acceptable fluorocarbons. carbomer. but not limited to the Dimethicone Cosmetically acceptable ketones — including. eye treatment. hair mousse. but not limited to the following: 25 Common formulations of pigmentation products com Ethanol Isopropanol n-propanol Cosmetically acceptable Esters — including. and 0% transmittance Was observed through a polished. mineralogical. octocrylene. PPG-12/SMDI copolymer. Sea & Ski. and the bioactive glass should be more effective at blocking UV radiation once it begins to react With human perspiration on the skin.5 Benzophenone 3 5. DMDM hydan Sunscreen Base Formula 60 toin. carbomer. While not The present invention provides for novel formulations of sun care products by incorporating bioactive glass into a combination of any of the above-listed ingredients. Pigmentation and sun care formulations comprising bio active glass provide enhanced UV protection as compared to formulations not comprising bioactive glass. phenethyl alcohol. 2-ethyl hexyl salicylate. Bioactive glass begins to absorb UV light at Wavelengths beloW 380 nm.0 Schott Glass sol-gel-derived bioactive glass dient avobenzone. ?uoroalkyldimethicone. emulsifying Wax NF. glyceryl stearate SE. avobenzone (parsol 1789). Generally. ben zalkonium chloride. Flents. Moreover. hydroxypropyl cellulose. Good Sense.250. these formula care formulations incorporating bioactive glass. shea butter. retinyl palmitate. Blue Lizard. cetyl palmi tate. polished sample of bioactive glass that Was reacted With tris-bulfered saline INGREDIENTS 7. Sun Splash. menthyl anthranilate. Elta Block. K. Biosun. benzyl alcohol. phenylbenzimidazole sulfonic acid.5 5. titanium dioxide. panthenol. 5 mm glass blank for UV light With a Wavelength beloW 280 nm. including sol-gel-derived bioactive glass. isohexadecane. ceteareth-20. J. proplyene glycol. petrolatum. bisabolo. PVP/eicosene copolymer. Off. homosalate. elastin. Tan. POI-111111215 CPD3-32. sorbitan Composition of Sunscreen Gel isostearate.0 100. thus improving the sun blocking characteristics of the bioactive glass With reaction time. The sun-blocking. oat extract. 100. DEA-cetyl phosphate.174 B2 17 18 (palm oil).0 EXAMPLE 2 35 Composition of Sunscreen Gel With Sol-gel-derived Bioactive Glass solution to form a surface precipitate of HAp Was tested. zinc oxide. iodopropynyl.0 30 100. alu minum stearate. Thus. stearyl alcohol. Sunbrellas. octyldodecy neopentanoate. surface precipitate is expected to scatter solar radiation. octyl salicylate. R. Kiss My Face. titanium oxide. and a moder ately good sunblock for the UVA (320-400 nm) region of solar radiation. dioctyl 50 EXAMPLE 3 phosphate. tribehe nin. and products produced by high-end and generic manufacturers. glyceryl monostearate-450. phenoxyethanol. Fruit of the Earth. methylparaben. cyclomethicone. tions help to mitigate the effects of sun allergies by releasing EXAMPLE 1 soluble calcium. butylene glycol. the reactive glass surface provides a protective HCA layer to offer additional UV protection. effectiveness of bioactive glass should 25 improve as a function of time.5 5. edetate disodium. Nature’s Gate. Hawaiian Tropic. dimethicone. The transmittance through the pre-reacted bioactive glass Was found to be less than that through the un-reacted bioactive glass at any Wavelength from 280 to 600 nm. imidazolidi nyl urea. tri methylsiloxysilicate. Examples 1-3 beloW provide exemplary embodiments of sun being bound by any speci?c theory.5 Octyl Methoxycinnalnate 7. mineral oil. octyl palmitate. hydrolyzed collagen. This porous. benzophenone-3. oxybenzone. octadecene/MA copolymer. isopropyl palmitate 65 INGREDIENTS % Jojoba Glaze 87. xanthan gum and diasolidinyl urea. PPG-15 stearyl ether.0 Schott Glass Bioactive Glass (<4 11 ave. aloe extract. Sol Bar. Esoterica. Native Tan. Jason. Thus. disodium EDTA. sun care products comprise the active ingre 40 INGREDIENTS Wt % Jojoba Glaze 45 82. In addition. stearic acid. after it is applied to human skin. bioactive glass should be an excellent 20 Composition of Sunscreen Gel With Bioactive Glass sunblock for the UVB (270-320 nm) region. sorbitan sesquioleate. oxybenzone. propy lparaben. o. PreSun. paraf ?n. butylcarbamate.0 or sulisobenzone.0 5.0 . tri?uoromethyl C1-4 and zinc oxide. C12-15 alkyl benzoate. Ti-Screen. acrylates/octylacrylamide copolymer. size) 5. Lily of the Desert. bioactive glass is considered an active sunscreen ingredient that Would improve over time as perspiration from the skin Would activate the scattering characteristics that are associated With the HAp-rich surface precipitate. Coppertone. L. triethanolamine. part. cetearyl alcohol. sorbitol. stearox ytrimethylsilane. Shade Sunblock. N. tocopherol acetate.US 7. Common formulations of sun care products comprise octyl methoxycinnamate. the high and irregular surface area of particulate bioactive glass is thought to contribute to this enhanced UV protection. Bioactive glass is expected to react With human per Wt % Jojoba Glaze 82. Water Babies.5 Octyl Methoxycinnalnate Benzophenone-3 spiration to form a porous. silica. s 55 Sun care products may also include one or more of the folloWing: PVP/hexadecene. jojoba oil. acrylates/C10-30 alkyl acrylate crosspoly mer. fragrance. polyglyceryl-3 distearate. The transmittance through a 5 mm thick. cetyl alcohol. Neutrogena. Water. ethyl hexyl P-methoxycinnamate. de Soleil. Bull Frog. PVP/hexadecene. No Ad. barium sulfate. Brite-Life. Panama Jack. Banana Boat. isopropyl myristate.A. DuraScreen. SD alcohol 40. the HAp layer formed by pre-reaction appears to scatter UV and visible light.5 Octyl Methoxycinnalnate Benzophenone-3 7. HAp-rich precipi tate at the glass surface. Thus. hydroxyquinoline. Huggies. d50:0. Chap-et. propylene glycol. fatty acids. Cashmere Bouquet. Little Forest. Gerber. CPD3-32 SISunscreen Base Formula+4% 58s. Gold Bond. 65 paes. sodium benZoate. aloe vera gel and fra grance. magnesium carbonate. polysorbate 20. mineral oil. Generally. and products produced by high-end and generic The anti-in?ammatory. Orly.250. Cl2-l5 alkyl ben Zoate.174 B2 19 20 CPD3-32 JISunscreen Base Formula (above). Baby Wipe and Handwipe. Boudreaux’s. Sween. Burt’s Bees. Oil of Olay. polysaccharides. sodium nonoxynol-9. Ammens. Herpecin-L. including nursing pads diaper products. d50:l. 55 polish remover products such as the products marketed under the brand names Almay. and Diaper Rash Products products comprise corn starch or talc. Nice ’N Clean. face powder. and products produced by high end and generic manufacturers. Fougera. diaper products by incorporating bioactive glass into a Nursing Pads (for Bras) combination of any of the above-listed ingredients. Tom’s of Maine. diaZolidinyl urea. d50:0. tocopherol acetate and various CPD3-32 K:Jojoba Glaze. Sally Hansen. 25 Common formulations of diaper rash products comprise petrolatum. 2-bromo-2 nitropane-l. isopropyl myristate. Pampers. and fragrance and/or antibac terial agents. Gerber. Jason. Cover Girl. Cetaphil. talc. baby powders. malic acid. methyl glucose ether. Paladin. Revlon. Tampax. lip treatment.77u ents. Borofax. L’Oreal. Baby Magic. Neutrogena. lipliner. synthetic mate rials which prevent leakage. Mex sana. trihydroxystearin. Jane. fatty alcohols or plant oils. phospholipid CDM. Curity. eyeliner and eye brow pencil. puri?ed rice bran ?our. body powders. baby wipe or hand wipe products comprise the active ingredient disodium cocoamphodiacetae. Peterson’s. disodium phosphate. Purell. Luvs. lip gloss. Max Fac tor. tricalcium phosphate and fragrance. methylparaben. Dr. Ones. methylparaben. glycerin. Johnson & Johnson. oleth-20. benZoic acid. The present invention provides for novel formulations of Formulas to be tested baby and hand wipe products by incorporating bioactive CPD3-32 OISunscreen Base Formula+2% 58s. vitamin and 20 The present invention provides for novel formulations of baby powder and body powder products by incorporating bioactive glass into a combination of any of the above-listed ingredients. Omron. Zinc oxide. antimicrobial. cocoam Bioactive glass may also be incorporated into various marketed under the brand names Curity. Diaper. nonoxynol 9. Shower to Shower. SD alcohol 40. dimethicone. Carmex. Even?o. Natural Ice. lanolin. Diaper Guard. retinyl palmitate. Wash-Up. Bonnie Bell. Ocusoft. Viractin. mineral. Good Sense. isostearic acid. bismuth subnitrate. The present invention includes novel formulations which incorporate bioactive glass into various brands of diaper. Caboodles. and hygroscopic herbal extracts. acetamidopropyl trimonium chloride. Calmoseptine. glass into a combination of any of the above-listed ingredi CPD3-32 RISunscreen Base Formula+4% 45s. Diaper Doubler. Softlips. NoxZema. phosphate. anti-in?ammatory. citric acid. diaper products comprise synthetic or natural absorbent materials which absorb moisture. Weleda. Tushies. Aloe Vesta. phospholipid EFA. nail polish and nail Baby and hand wipe products may also include one or more of the following: cocamidopropyl PG-dimonium chlo mer. polyaminopropyl biguanide. The antimicrobial. Kleenex. In addition. The present invention provides for novel formulations of diaper rash products by incorporating bioactive glass into a combination of any of the above-listed ingredients. eyeshadow. Chapstick. bioactive glass may be used in so-called adult brand brands of nursing pad (for bras). Alpha Hydrox. Liquimat. Playtex. Wet lkonium chloride and various fruit. Suave. Kid Fresh. propylene glycol and PEG-60. aminomethyl propanol. and hygoscopic 40 properties of bioactive glass are particularly useful in diaper rash products to reduce in?ammation.6p. Chat term. PEG-75 lanolin. Drypers. J ohnson’s. In addi tion. 8-hydrox yquinoline sulfate. Black Radiance. Goodnites. lipstick. Milani. Neutrogena.US 7. M Professional. rash and odors. United Colors of Benetton Cosmetics. silica. abolol. Maybelline.3-diol. Brite-Life. Baby powder and body powder products may also include baby wipe and hand wipe. Baby Powder and Body Common formulations of baby powder and body powder Powder Products. alkyl polyglycoside. Little Bottoms. Des itin. polyparaben and imidaZolidinyl urea. Common formulations of baby and hand wipe products comprise water. acrylates/Cl0-30 alkyl acrylate crosspoly 60 benZalkonium chloride. aloe vera gel. Coty. bento products such as the products marketed under the brand nite (natural clay). Pull Ups. Ultimates. Clinipad. SPF~l5 ethicone. microcrystalline wax and para?in. diaper rash products comprise Zinc oxide and ?sh or cod liver oil. Bari. Vaseline. and a moisturizer such as aloe gel. SPF~0 CPD3-32 NISunscreen Base Formula+2% 45s. potassium sorbate. a protectant such as silicon oil. Aveeno. Phisoderm. Generally. Blistex. bis 35 Generally. 30 properties of bioactive glass are particularly useful in dia borax. sorbic acid. Caldesene. Cutex. manufacturers. Burt’s Bees. . DMDH hydantoin. baby powder and body powder one or more of the following: tricalcium phosphate. concealer foundation. Flander’s. fragrance. 45 The antimicrobial and anti-in?ammatory effects of a bioactive glass are particularly useful in nursing pads (bras) to reduce in?ammation. water. blush. disodium EDTA. 50 Makeup Products The present invention includes novel formulations which phodiacetate. Aromathera ride phosphate. diaper rash products and moist towelettes to reduce in?ammation. sodium bicarbonate. baby powder and body powder products com prise talc and/or corn starch. Smiles. Clinipad. Comfort Bath. Stay Free. Health?ow. acrylates copoly mer. Purpose. Vaseline. Loud Music. mineral oil. Brite-Life. cod liver oil. G&W. Generally. sim incorporate bioactive glass into various brands of makeup products including mascara. Dermatone.77l p. Zinc oxide and fragrance. propylparaben. potassium laureth phosphate. camphor. PPG-20. ethyl alco hol. Nature Boy & Girl. Garden Botanika.6p. bioactive glass can reduce the acidity of urine and is activated by the aqueous nature of urine. Alpharma. benZoic acid. kaolin clay. Cottonelle. Smith’s. Savex. Diaparene. Pure ’N Gentle. Balmax. Zinc stearate. pers. tetrasodium EDTA. Chubbs. rash and odors. silicone. Kid Care. rash and odors. benZa names A&D. The present invention provides for novel formulations of Diaper rash products may also include one or more of the following: balsam. d50:l. vitamin and plant extracts. castor oil. . stearic acid. 55 The present invention provides for novel formulations of tic acid. camauba Wax. butyl stearate. glyceryl stearate. carmine. arachidyl behenate. ascorbic acid. oleic acid. methylparaben. eyeliner and eyebroW pencil products comprise talc. isopropyl triisostearoyl titanate. manganese violet. trilaurin. sodium dehydroacetate. MlPA-lanolate. propylene carbonate. monostearate. cyclopentasilosane. tristearin.174 B2 21 22 Wet ‘n’ Wild. Common formulations of eyeshadoW products comprise hydrogenated ?sh oil. potassium Ocotxynol. mellisic acid. ?uorethylene. methyl polysiloxane. pentahydrosqualene. diaZolidyl urea. polysorbate 60. PEG-8. C9-ll isoparaf?n. nylon-l2. silica. Zinc min. butylene glycol. imi 30 onate ceresin. ethylene/methacrylate copolymer. butylparaben. propylene glycol. talc. synthetic Wax. quatemium-l8 hectorite. PVP laureth-4. folloWing: ascorbyl palmitate. kaolin. mimosa Wax. methylparaben. japan Wax. microcrystalline Wax. butylparaben. The present invention provides for novel formulations of mascara products by incorporating bioactive glass into a combination of any of the above-listed ingredients. cerotic acid. stearate. tricontanyl PVP. pro acid. benZyl alcohol. bronZe poWder. The anti-in?ammatory and antimicrobial effects of bio active glass are particularly useful in makeup products to reduce bacteria and in?ammation.250. silica PTFE. hydrogenated oil. sodium lauryl sulfate. acrylates copolymer. paraf?n. bismuth oxychloride. microcrystalline Wax. styrene/acrylates cyclomethicone. calcium silicate. retinyl palmitate. phenoxyethanol and various col conol. a Wax prod uct. acacia. trimethylsiloxysilicate. cyclomethicone. hydgroplex Hhg Whn. boron nitride. acrylates copolymer. quatemium-l8 bentonite. silk poWder. candelilla Wax. polymethyl methacrylate. mica. copper poWder. caprylic/capric acid tryglyceride. magnesium stearate and coloring agents. eyeshadoW products comprise talc. sodium laureth sulfate. polyquatemium l0. polyvinylidene octyldodecyl stearoyl stearate. Generally. soy amino acids. mineral oil. acrylates copolymer. products comprise cyclomethicone. chro mium hydroxide green. trim 40 ethylsiloxysilicate. ultramarines and xan than gum. PPG-l5. simethicone. ceresin. polyethylene. para?in. Generally. quaternium-l8. sorbitan stearate. titanium dioxide. chromium oxide greens iron oxides. iron oxides. 65 methoxypropylgluconamide. fragrance. Mascara products may also include one or more of the The present invention provides for novel formulations of combination of any of the above-listed ingredients. vita polyethylene. isopropyl Cl2-l5-pareth-9 carboxylate. blush products comprise talc. iron oxides. coco caprylate caprate. hectorite. ultramarines. MlPA-oleate. glyceryl stearate. glyceryl rosinate. sorbitan sesquioleate. ascorbyl palmitate. methacrylate. glycerin. poly ethylene ?uorethylene. propyl. Zinc oxide. silica. pentaerythrityl tetrastearate. talloW glyceride. titanium dioxide. D1 tocopherol. lacrylamide/acrylates/butyl aminoethyl methacrylate copolymer. chitin extract. Water. isoceteth-20. isostearyl behenate. Zilactin. saturated fatty acid glycerides. Eyeshadow products may also include one or more of the active glass into a combination of any of the above-listed ingredients. lipophilic glyceryl monostearate. triethylamine. 20 Common formulations of eyeliner and eyebroW pencil folloWing: mica. imidaZolidinyl urea. ascorbyl palmitate. sodium polymethacrylate. magnesium stearate and coloring agents. ferric ammonium ferrocyanide. EDTA. glycerin. hydro genated vegetable oil. silk poWder. cetyl palmitate. PPG-5 eteth-20. disodium octy oring agents. triclosan. TEA-stearate. butylparaben. caprylic/capric acid triglycer ide. stearyl heptanoate. ammonium acrylates copolymer. sorbitan laurate. hydroxyethyl cellulose. propylparaben. diaZolidinyl urea. polyethylene. saturated fatty acid glycerides. chromium hydroxide green. parahydroxyben copolymer. ammonium lanolate. lauryl lysine. pentahy drosqualene. mica. PEG. dimethi phosphate. retinyl palmitate. sodium dehydroacetate. SD alcohol 40-B. trioctanion. citric acid. paraf?n. tocopheryl acetate. synthetic beesWax. lecithin. sodium hyalur onate. parahydroxybenZoate ester. mineral oil. ultramarines. cocoamphodiacetate. candelilla Wax. ammonium hydroxide. nnoxynol-lO. mascara products comprise talc. hydrogenated palm glycerides. Common formulations of mascara products comprise Zoate ester. hydrolyZed corn starch.l 2. lauroyl lysine. magnesium aluminum silicate. hydrolyZed keratin. nylon-l2. toco pheryl acetate. quatemium-22. carnauba Wax. myricyl alcohol. chromium oxide greens. dimethicone. hydroxyethylcellulose. beesWax. butyl stearate. tocopherol. alumi num poWder. butylene glycol. dehydroace extracts. ammo nium hydroxide. hydrogenated castor oil. candelilla Wax. methyl ethyl propyl butylparabens/phenoxyethanol. magnesium carbonate. beesWax. 60 Cl2-Cl5 alkyl benZoate. hydroxyethylcellulose. ferric ferrocyanide. soybean phospholipid soybean leci Generally. hydrogenated coco-glycerides. propylene carbonate.3-octadecanediol and propylparaben. Zinc stearate and various vegetable and plant stearate. carnauba cetyl alcohol. polymethyl synthetic Wax. bismuth oxychloride. benZyldimethylstearylammonium hectorite. hydrogenated cottonseed oil. copolymerm. 35 noxyethanol. stearic acid. aluminum poWder. panthenol. various mineral. lanolin.100 stearate. polybutene. polysorbate 20. cetyl stearate. and coloring agents. citric acid. cetyl alcohol. ipphilic glyceryl monooleate. polyglycery-4 isostearate. BHT. aloe extract. a preservative. polyethylene. carmine. BHA. trisodium EDTA. 25 Eyeliner and eyebroW pencil products may also include one or more of the folloWing: PPG-2 myristyl ether propi candelilla Wax. cetyl alcohol. neopentyl glycol diisooctanoate. diglycol/CHDM/lsophthalates/ sip copolymer. alcohol denatured. per?uoropolymethyliospropeth Water. vegetable oil. PVP copolymer. rocyanide. titanium dioxide. Generally. octyl palmitate. talc. iron oxides. oleostearine. lipophilic glyceryl 50 thin. quaternium-l5. hydroxylated lanolin. tribehenin. methylparaben. oleyl alcohol. isopro eyeshadoW products by incorporating bioactive glass into a pyl titanium triisostrearate. laurylmethicone copolyol. mica. ?sh glycerides. methyl pol 45 ysiloxane. boron nitride. manganese violet. hydrogenated coco-glycerides.US 7. Woltra. citric polyvinyl alcohol. quatemium-l5. a preservative and coloring agents. ethylparaben and eyeliner and eyebroW pencil products by incorporating bio diaZolidinyl urea. Common formulations of blush products comprise dime thicone. stearic acid. 2-olea mido-l. kaolin. talc. dimethicone. phosphate. tocopheryl acetate. lecithin. an emollient. aminom ethyl propandiol. silk poWder. mica. oZokerite. dazolidinyl urea. polyglyceryl-3 diisostearate. lecithin. ferric ammonium fer pylene carbonate. nylon-l2. talc. triethanolamine. PVP silica. hydrolyZed glucosaminoglycans. BHA. soybean phos pholipid soybean lecithin. polyethylene. chromium hydroxide green. carmine. ethylpa raben. PTFE. benZyldimethyl stearylammonium hectorite. camuba Wax. hydroxylated lanolin. cetyl esters. Zinc oxides. and products produced by high-end and generic manufacturers. PPG 17 copolymer. phe propylparaben and BHT. aloe extract and allon toin. isopropyl titanium triisostearate. ucts comprise Water. Common formulations of face poWder products comprise talc. cam phor. various coloring agents. isotridecyl isononanoate. imidaZolidinyl urea. polyglyceryl-4 isostearate. pectin. para?in. lanolin. bismuth oxychloride. panthenol. methylparaben. oZokerite. Cl0-20 cholesterol/lanosterol esters. iron dioxides and ultramarines. various coloring 50 The present invention provides for novel formulations of face poWder products by incorporating bioactive glass into silicate. magnesium sulfate. myristyl lactate. isobu tylparaben. octyl palmitate. allantoin. trioctan ion. iso propyl palmitate. methyl polysiloxane. 55 Generally. aluminum starch isoeicosane. stearoxytrimethylsilane. menthol. sodium dehydroacetate. diaZolidinyl urea. allantoin. calcium stearate. glyceryl stearate. alkyl octanoate. ultramarines and various coloring agents. quatemium-l8 hec 65 torite. octyldodecanol stearoyl stearate. dicaprylate/ dicaprate. trihydroxys 20 The present invention provides for novel formulations of The present invention provides for novel formulations of blush products by incorporating bioactive glass into a com bination of any of the above-listed ingredients. bisa codyl. kanolin. menthol. calcium silicate. menthol. BHA. Cl2-l 5. candelilla Wax. quatemium-l8 hectorite. polysor bate 20. . Zinc stearate. propylparaben. and coloring agents. lipo agents. hydrolyzed veg lidinyl urea. octyl palmitate. aluminum hydroxide. lanolin. PEG-6. linoleate. Blush products may also include one or more of the following: acetylated lanolin alcohol. cetearyl octanoate. Common formulations of concealer and foundation prod 30 octenylsuccinate. octamethyl cyclotetrasiloxane. ingredients. cellulose gum. cocoyl sarcosine. polyglyceryl-6-polyricinoleate. octyl hydroxystearate. retinyl palmitate. cetyl alcohol. tridecyl trimellitate. trisodium EDTA. fragrance. etable protein. bisabolol. sodium lauroyl sarcosinate. quaternium-l5. silica. triclosan. mica. tetrasodium EDTA. benZoic acid. isostearyl palmitate. fragrance. Concealer and foundation products may also include one or more of the folloWing: paraf?n. retinyl palmitate. sodium hydrogenated talloW glutamate. hexyl lau rate. concealer and foundation products comprise concealer and foundation products by incorporating bioac tive glass into a combination of any of the above-listed 25 titanium oxide and coloring agents. BHA. carbomer. isooctahexacontane. lecithin. propylene glycol. sodium chloride. silica. acrylates copolymer. acetylated glycol stearate. tocopheryl acetate. silica. ethylparaben.250. bismuth oxychloride. trimethylsiloxysilicate. sorbitan sesquioleate. acetylated lanolin. aminoethylpropanol. stearic acid. acety lated lanolin alcohol. SD alcohol 40 b. titanium butylparaben. ultramarines. polysorbate 80. sodium dehy droacetate. bis digly-ceryl caprylate/caprate/isostearate/stea. glyceryl rosi nate. clove oil. diaZolidinyl urea. kaolin. cethyl acetate. camphor. monate. polyethylene. propylparaben and phenoxyethanol. tricontanyl PVP. propylene glycol. tocopheryl acetate. ferric ammonium ferrocyanide. dimethicone. sorbic acid. synthetic beesWax. cyclomethicone. titanium dioxide. lanolin alcohol. methyl-ethyl-pro pyl-ibutylparabens/phenoxyethanol. isopropyl isostearate. retinyl palmitate. bismuth oxychloride. lauryl lysine and methyldihydroias philic glyceryl monostearate. isos tearyl alcohol. caprylic/capric triglyceride. cetyl dimethicone ?our. ethylene/vinyl acetate copolymer. 35 folloWing: acetylated lanolin alcohol. poly butene. phenoxy ethanol. acrylates copolymer. Generally. dimethi Face poWder products may also include one or more of the cone copolyol. barium sulfate. lipstick and lip gloss products comprise castor oil. tocopheryl dioxide. octyl stearate. castor oil. tearin. methylparaben. hydrogenated coco-glycerides. trin. DMDM hydantoin. methicone. boron nitride. phenyl dimethi cone. PEG-20 methyl glucose sesquistearate. sodium hyaluronate. imidaZo polymethyl methacrylate. oat ?our. hydrogenated coco-glycerides. ascorbic acids. candelilla Wax. PEG-2 stearate. quatemium-l5. Generally. beesWax. calcium chloride. methylpara copolymer. calcium silicate. camauba. BHA. silk poWder. lauroyl lysine. titanium quinone. Cl2-l5 alcohols octanoate. mineral oil. polysorbate 20. ascorbyl palmitate. Water. polyoxymethylene urea. synthetic Wax. isododecane. alcohol denatured. sodium stearate. propylparaben.174 B2 23 24 sorbitan trioleate. quaternium a combination of any of the above-listed ingredients. titanium dioxide. diaZolidinyl urea. silica. kaolin. and coloring agents. isostearyl neopentanoate. tin oxide. phenoxyethanol. carrageenan. cetyl alcohol. octyldodecyl stearoyl stearate. car copolyol. silk poWder. sorbitan trioleate. mica. xanthum gum and various coloring agents. polysorbate 60. ascorbyl palmitate. laureth-7. disodium EDTA. PEG-20 sorbitan beesWax. titanium dioxide. octyldodecyl stearoyl stearate. sodium hyaluronate. carmine. octyl salicylate. eucalyp eryl-6. mineral oil. ethylene/methacrylate copolymer. aluminum starch octenylsuccinate. polyisobutene. sodium dehydroac stearyl alcohol. imidaZolidinyl urea. ethylene brassylate. carmine. salicylic acid. tridecyl trimellitate. octyldodecy neopentanoate. hydrogenated poly isobutane. magnesium carbonate. cetearyl alcohol. lecithin. dimethicone. magnesium aluminum silicate. hydrogentated lecithin. triethanolamine. methylparaben. tetrasodium edtapropylparaben. diisostearyl malate. PVP. lauroyl lysine. stearyl stearoyl stearate.US 7. pentaerythrityl tetrastear ate. propylene tus oil. a preser vative. tristearin. cethyl acetate. eucalyptus oil. trimethylsiloxysilicate. nylon-l2. casein. ceteareth-20. manga glycol. BHT. oat 45 l5. triethanolamine. polyglyc caprylate caprate. methyl glucose sesquistearate. isopropyl palmitate. ultramarine blue. glyceryl rosinate. PEG-20 sorbitan bees Wax. lanolin oil. octyl methoxycinamate. polyglyceryl-3 diisostearate. per?uoropolymethylisopropyl ether. ascorbyl palmitate. dextrin. aloe extract. BHT. phenyl trimethicone. bentonite. disopropyl dimer dilinoleate. dex aloe extract. Zinc stearate. butylparaben. bees 40 manganese violet. octyldodecyl myristate. octyldodecyl myristate. Wax. Zinc stearate. BHT. ethylparaben. benZoic acid. isopropylparaben. octyl hydroxystearate. caprylic/ capric triglyceride. butylene glycol. dimethiconol. face poWder products comprise talc. panthenol.l 8 hectorite. stearic acid. Cl2-l5 alkyl benZoate. mineral oil. ben. mineral oil. various plant extracts. tocopheryl acetate. fragrance. quatemium. nese violet. kaolin. mica. talc. iron dioxides and various coloring agents. calcium aluminum boro nauba. caprylic/capric triglycerides. tribehenin. methicone. t-butyl hydro etate. microcrystalline Wax. ferric ferrocyanidea. PEG-32. barium sulfate. aluminum stearate. coco PEG-100 stearate. iron oxides. dipropylene glycol. polyethylene. glycerin. arachidyl behenate. calcium silicate. ascorbyl palmitate. midaZolidinyl urea. setereth-2. clove oil. mica. magnesium stearate. ethylene/acrylic acid nylon-l2. butylparaben. Common formulations of lipstick and lip gloss products 60 comprise trictyldodecyl citrate. ricinoleate. alkyl benZoate. octyldodecanol. magnesium sulfate. iron oxides. various plant extracts. isocetyl stearate. Water. sorbi tan sesquioleate. panthenol. dioctyl adipate. BHT. silica. petrolatum. va/vinyl butyl benZoate. PEG-8. cyclomethicon. 0 2.250. ascorbyl palmitate. bronZe powder.0 i i 10. isocetyl stearate. phenol. oxybenZone. isobutyrate.0 15. PVP/hexadecene copolymer. wheat germ oil.6 p Bioglass 58s @ 0. polyphenylmethylsiloxane 556. padimate. The present invention provides for novel formulations of dipentaerythrityl hexacaprate/hexacaprylate. octyl palmitate. hydrogenated veg etable oil.0 25. ceresin. silica. carmine. C10 INGREDIENTS 30 cholesterol/lanosterol esters. dioctyldodecyl ?uoroheptyl citrate. cetyl octanoate.6 2. hydrolyZed glucosaminoglycans. oZokerite.0 3. man ganese violet methylparaben.0 1.2 0. allantoin. magnesium ascorbyl phosphate.0 Part A 55 60 preservative. BHA. saccharin. hydrogenated vegetable oil. sodium phosphate. borage seed oil. oZokerite. B. isopro 20 0. bisabolol. size) acetate. sodium saccharin. benZoic acid. bisacodyl.0 15. BHT.0 1. 0. phenyl trimethicon and BHT. petrolatum. healants and protectants such as petrolatum jelly. polybutene.0 Vitamin E 15. bis-diglyceryl polyacyladipate-2. octyl methoxycinamate. cethyl Methyl Paraben Propyl Paraben Schott Glass 45s5 (<4 11 ave. PEG Wt % A fragrance. C The present invention provides for novel formulations of 50 lip treatment products by incorporating bioactive glass into a combination of any of the above-listed ingredients. oZokerite.0 3. pentaerythrityl tetraisostearate. pro pyl gallate and citric acid. stearyl dimethicone. para?in. hexyl laurate. 3) The Talc formula showed more feathering (bleeding) at 1 hr. octyl methoxycinnamate. panthenol. petrolatum.0 7. isopropyl palmitate.0 Castor Oil Carnauba Wax Candellila Wax Ozokerite Wax 30. ceresin. carnuba wax. beeswax.174 B2 25 Lipstick and lip gloss products may also include one or more of the following: acetylated lanolin. corn oil. hydrogenated soy glyceride. sodium lactate. coconut oil.0 25. T-butyl hydroquinone. beeswax.0 i i i i 10.77 p 100.2 0. citric acid. polybutene.0 15. beeswax. Zinc sulfate. cocoa butter. sun?ower seed oil. Lip treatment products may also include one or more of hydroxystearin. soya stearol.0 100.0 2.0 15. polythylene. sodium saccaharin. ethylhexyl P-methoxycinnamate. microcrystalline wax. cyclomethicone.0 15. talc. salicylic acid.2 0. nylon-12. polyethylene. various coloring agents. polyglyceryl-4 isostearate.1 Bioglass 45s @ 1. Formulas CPD3-33 A.1 0. bismuth oxychloride. dimethicone. various natural and arti?cial ?avorings. sodium PCA. octyl hydroxystear ate. propylparaben. disostearyl dimer dilinoleate. hydrogenated cot tonseed oil. car nuba wax. mixed wax. 20 tetrabehenate. hydrogenated castor oil. octadecene/ma copolymer. padimate. stearyl alcohol.0 30. hydrolyZed collagen. wax paraf?n and white wax. polyglyceryl-3 diisostearate. tocopheryl acetate. candelilla wax. arachadyl propionate. arachidyl propionate. propyl gallate.0 7. lanolin. tridecyl trimellitate.0 3. aloe extract. oxybenZone . allantoin. methicone. cyclotetrasiloxane. sesame oil. fragrance. tocopheryl acetate. propy 30 stearic. various vitamin agents. stearic acid. drometriZole. Dl-tocopherol. stearic acid and coloring agents. sodium saccharin. camphor. 2) The 58s glass formula set up somewhat faster and appeared to make a smoother product as compared to the 45s glass formula. hydroxylated milk glycerides.6 2. cetyl esters. mineral oil. isopropyl lanolate. lip treatment products comprise moisturizers.0 Microcrystalline Wax Jojoba Oil 3. methylparaben.1 Observations: 1) The Talc Formula did not set as well/quickly as either sesquistearate. trimethyl siloxysilicate. Lipliner products may also include one or more of the following: aloe extract. ethylcellulose. menthol. camuba.0 1.0 100. propylparaben. paraf?n. lipstick and lipgloss products by incorporating bioactive glass. tridecyl stearate. 2-octyldodecanol. hydrogenated soy glyceride.US 7. microcrystalline wax. mica. poly . cetyl dimethicone copolyol. triisostearin esters.0 30. grapeseed oil.0 7. fragrance. trilsostearin. hydrogenated poly lactate. diisopropyl. alum.0 pyl myristate. castor oil. cyclomethicone. stearic acid. D-tocopherol. cetyl alcohol. hydrogenated castor oil. urea. into a combination of any of the above-listed ingre dients. triisostearyl citrate. Common formulations of lip treatment products comprise white petrolatum. tri?uoromethyl C1-4 alkyl dime thicone. 40 Example 4 below provides an exemplary embodiments of lipstick formulations incorporating bioactiv glass. isostearyl palmitate. butylparaben. lipliner products comprise a wax product. part. 25 lene glycol. SD alcohol 36. mineral oil. dimer dili pentaerythrityl 10.1 0.0 2. dimethicone. benZophenone-3. sodium hyaluronate.1 0. squalane. Generally. kukui nut oil. octyl palmitate. glyc eryl oleate. castor oil.0 glass. acrylates copoly -continued mer. 65 hydrated silica.0 1. polyethelene. bismuth oxychloride. Common formulations of lipliner products comprise cas tor oil. sucrose acetate 0. propylene glycol. polymethysilses quioxane. EXAMPLE 4 45 Lipstick with Bioglass puri?ed water. myristyl beeswax. butylparaben. shellac wax. sorbic acid.1 Wt % B Part C noleate. trissostearyl citrate.0 1. mineral oil. neopentyl glycol dicoctanoate.0 1. lecithin.0 3. dimethicone. PEG-6 beeswax. PPG 51/smdi copolymer. various natural and arti?cial ?avorings and various plant extracts. carnauba. tri capric triglyceride. oleyl alcohol. retinyl palmitate. copper powder. Generally. isododecane. meadowfoam seed oil.6 2. sesame oil. methyl glucose sorbitan Wt % C Talc USP isobutene. water. cyclopen tasiloxane. polyglyceryl-2 diisostearate. menthol. caprylic/ 35 the following: 2-ethylhexyl salicylate.0 25. iron oxides. lanolin. para?in. phytosterol/oc tyldodecyl lauroyl glutamate. a INGREDIENTS wt % A wt % B wt % C Red 7 Ca Lake Red 6 Ba Lake Red 33 Al Lake Castor Oil Part B 3. cocoa butter. octyldode canol. poly butene. lanolin. castor oil. various natural and arti?cial Composition of Anhydrous Nail-Strengthening Gel ?avorings. glyceryl tri I palmitate. size) 90. Jojoba Glaze The present invention provides for novel formulations of nail polish products by incorporating bioactive glass into a 55 combination of any of the above-listed ingredients. titanium dioxide. tocopheryl acetate. chromium hydroxide green. tetrabutyl phenyl Pemulen ® TR-2 hydroxybenzoate. 45 Composition of Skin and Nail Treatment (Anhydrous With Sol-gel-derived Bioactive Glass) polyester resin. guanine. 80. 100.5 Talc . Nail polish products may also include one or more of the folloWing: acrylates copolymer.05 40 100. This mineralogical layer is expected to add strength to 65 dimethyl glutarate. nail polish products comprise nitrocellulose. soybean phospho lipid. biotin.USP 2. Schott Glass Bioactive (<4 u ave. tetrabutyl phenyl hydroxy benzoate. quatemium-18 bentonite. hydrated 30 Composition of Nail Gel (Anhydrous With silica. hydroxyapatite). ferric ammonium ferrocyanide. titanium dioxide. fragrance. N-butyl alcohol. phosphorous. iron dioxides. stearalkonium hectorite. 2. Bioactive Glass) methyl acetate. size) tosylamide/epoxy resin. tosylamide/formal dehyde resin. hydrolyzed keratin and various coloring agents. tribenzoin. propyl nail care formulations incorporating bioactive glass.45 9.4-di-t-butylphenyl-3. dipropylene glycol dibenzoate. acetyl tributy citrate. various col oring agents. tocopheryl acetate.5-di-t-butyl-4 hydroxyben and tin II 20 oxide. size) combination of any of the above-listed ingredients. benzophenone-l. nails. phthalic anhydride/glyc erin/glycidyl decandate cop. toluene. agents. 50 INGREDIENTS etocrylene.e. ethyl tosylamide. caprylic/capric acid triglycerides. soybean lecithin and lipophilic glyceryl monostearate.00 tribenzoin. phosphoric acid. malic acid.0 25 ride. dipropylene glycol diben zoate. castor oil and various coloring ing sol-gel-derived bioactive glass. These inorganic elements can precipitate on 60 Common formulations of nail polish remover products comprise ethyl acetate. part. acrylate copolymer. sodium EXAMPLE 5 saccharin. oxidized polyethyl ene.250. Examples 5-8 beloW provide exemplary embodiments of Generally. sucrose acetate isobutyrate. cam phor. glycois copolymer.5 Brown Iron Oxide Titanium Dioxide 0. diglycerol. propyl acetate. phthalic anhydride/trimellitic anhydride/glycols copolymer. Wt % 91. dimethyl adipate. dibutyl phthalate. . dimethyl succinate. bismuth oxychloride.5 Schott Glass sol-gel-derived bioactive glass 5. INGREDIENTS The present invention provides for novel formulations of lip liner products by incorporating bioactive glass into a Wt % Jojoba Glaze Schott Glass Bioactive Glass (<4 u ave. Common formulations of nail polish products comprise EXAMPLE 6 ethyl acetate. synthetic Wax. glyceryl tribenzoate.0 diacetone alcohol. tosylamide/formaldehyde resin.5 0. toco pheryl acetate. dimethicone copolyol. polyester resin. saturated fatty acid glycerides. benzophenone-l. aluminum. isopropyl alcohol. amyul acetate. guanine. 35 INGREDIENTS Wt % styrene/acrylates copolymer. manganese violet. mica..50 styrene/acrylates/acrylonitrile copolymer. titanium dioxide. biotin. polyethylene terephithlate. silica. ferric ferrocyanide.174 B2 27 28 butene. benzophenone-l.0 20. glycerin. SD alcohol 40. acetyl tributyl citrate.US 7. chromium oxide greens. isopropanol. panthenol.0 lacquer dissolved in solvents such as acetone or ethyl alcohol and coloring agents. various coloring agents. fragrance. ultramarines. nitrocellulose. aluminum poWder. silver. etocrylene.0 10. heptane. retinyl palmitate. phthalic anhydride. glyceryl triacetate. a 100. part. iron oxides. isobutyl acetate. butyl acetate. nail polish remover products comprise acetone or ethyl acetate. panthenol. sodium and silicon. retinyl palmitate. zinc oxide.0 Bioactive glass and sol-gel derived bioactive glass reacts 100. retinyl palmitate. mica. diacetone alco hol. stearalkonium hectorite.0 Generally.0 With aqueous ?uids to form a solution that is rich in inorganic elements. dimethicone EXAMPLE 8 copolyol. algae extract. citric acid. such as calcium. alcohol. parahydroxybenzoate ester. nails to form a mineralogical layer (i. EXAMPLE 7 ferric ammonium ferrocyanide. trimellitic anhydride. asorbyl palmitate. ?ber glass. bismuth oxychlo INGREDIENTS Wt % Jojoba Glaze Schott Glass Bioactive Glass (<4 u ave. Water. Glycerin 90. dibutyl phthalate. sucrose acetate isobutyrate. part. stearalkonium Composition of Anhydrous Nail-Strengthening Gel bentonite. includ acetate. calcium pantothenate. gelatin. 0. propylene carbonate. cocamidopropyl attapulgite. titanium dioxide. Bioactive glass can be used in topical benZoate. fragrance. hydroxypropyl methylcellulose. Bur‘ts’s Bees. Plenitude. ammonium hydroxide. Aconmel. parachlo 55 rometaxylenol. Ten-O-Six. and products produced by high-end and generic manufacturers. Jergens. sodium polynapthalene sulfonate. Pond’s. glycerin. maxipad and pantiliner products such as the products mar keted under the brand names AlWays. Clearasil. exfo liating products and makeup removal products comprise incorporate bioactive glass into various brands of acne prevention and treatment products such as the products marketed under the brand names Acne Aid. Revlon. BHT. facial cleansing. ReZamid. ammonium alcohol. Maxipad and Pantiliner Products The present invention includes novel formulations Which Products The present invention includes novel formulations Which incorporate bioactive glass into various brands of tampon. Hyland’s Homeopathic. The present invention provides for novel formulations of acne prevention and treatment products by incorporating lauroamphodiacetate. generic manufacturers. aluminum hydroxide. Vegee Tonic. sodium magnesium. beta carotene. lau reth-9. Johnson & Johnson.174 B2 29 30 Nail polish remover products may also include one or The antimicrobial and anti-in?ammatory properties of more of the following: acetone. Brite-Life. chromium hydroxide green. hydroxycetyl hydroxyethyl 60 dium hedta. Oil of Olay. boric acid. mineral oil. myristic . Jason. Earth Science. bioactive glass into a combination of any of the above-listed methylchloroisothiaZolinone. methylparaben. toning. ceresin.250. edetate 65 dimonium chloride. Seban. lonax. 45 products comprise active ingredients consisting of a com bination of resorcinol. Stridex. cary lates/steareth-20. disodium oleamido PEG-2 sulfosuc cinate. lauryl phosphate. methylisothiaZolinone. lonax. methylparaben. acne prevention and treatment products com Common formulations of acne prevention and treatment acid. Oxy. methyl lactate. ethylparaben. Biore. Exfoliating and Makeup Removal Tampon. Toning. disodium disodium. Purpose. Clearasil.US 7. carbomer. Pond’s. benZyl prise the active ingredient benZoyl peroxide or salicylic acid. sodium chloride. methacrylate copolymer. dicaprylate/dicaprate. cetyl hydroxyethylcellulose. isopropyl palmitate. hydroxyethylcellu lose. citric acid. iron oxides. camphor. Neutrogena. Suave. simethicone. While also killing the bacteria and micro-organisms that cause acne. sodium bisul?te. methyldibromo glutaronitirle. maxipad. panthenol and tocopheryl acetate. Dickinson’s. Maxipad and pantiliner L’Oreal. Almay. Bodycology. lactic acid. propy lene glycol. denatonium bioactive glass are particularly useful in acne prevention and treatment products. sodium hydroxide. Aqua Glycolic. Generally. glyceryl stearate SE and PEG-l2. glyceryl laurate. cocamidopropylamine dioctyl sodium sulfosuccinate. iodopropyl butylcarbamate. talc. NoxZema. acrylate crosspolymer. cocamidopropyl betaine. Albolene. sodium cocoate. T-Zone. diso dium EDTA. ethoxydiglycol. Liquimat. Water. Neutrogena. sodium borohydride. hexylene glycol. PEG-8 laurate. butylene glycol. various vitamin. microcrystalline Wax. Keri. Clean & Clear. Propa pH. fruit and vegetable extracts and various coloring agents. Ar‘tra. Sulforcin. Acne Prevention and Treatment Products The present invention includes novel formulations Which hydroxide and an exfoliant such as alpha or beta hydroxy 30 Kiss My Face.. Stiefel. Burt’s Bees. Aveeno. lanolin oil. potassium hydroxide. phosphatidyl pg-dimonium chloride. and prod ucts produced by high-end and generic manufacturers. cocamide mea. Ives SWiss Formula. Pemox. glycol DS. cetyl alcohol. Sea BreeZe. Facial Cleansing. Bioactive glass may be incorporated into a combination of any of the above-listed ingredients. glyceryl stear ate. ingredients. Sulfur Soap.b. plastic and adhesive strips. butylparaben. Tampax. Orange Daily. corn germ oil. tampon products comprise cotton and/or rayon overWrap and cotton cord. 25 The antimicrobial and hygroscopic effects of bioactive glass are particularly useful in tampon. triso disodium. Stridex. tocopheryl acetate. methyl gluceth 20. citric acid. 35 carbamate. chlorhexidrine digluconate. acne creams to reduce in?ammation. sodium talloWate. DML. colloidal oatmeal. Acne prevention and treatment products may also include one or more of the folloWing inactive ingredients: alcohol. exfoliating products and makeup removal incorporate bioactive glass into various brands of facial products such as the products marketed under the brand Playtex. propylparaben. allantoin. 50 cetyl octanoate. Sulpho-Lac. toning. Cetaphil. Moisturel. Generally. aZelaic acid or adapelene. Desert Essence. isocetyl alcohol. Kotex. and a plastic or cardboard applicator. Kiss My Face. Cover Girl. Ambi. cetearyl isononanoate. Maybelline. calcium hydroxide. butylparaben. dea-cetyl phosphate. iodopropynl butyl Generally. menthol. Aveeno. xan than gum. cetearyl alcohol. Common formulations of facial cleansing. car bomer. and exfoliating products and makeup removal products may also include one or more of the folloWing: l-hexadecanol. Biore. Sebasorb. retinoic acid. imidaZolidinyl urea. Generally. panthenol. Carefree. menthol. Salicylic Acid. kaolin. fragrance. St. dimethicone. Clean & Clear. citric acid. lauric acid. caprylic/capric triglyceride. isopropyl myristate. polysorbate-20. diaZolidinyl urea. lauryl polyglucose. EDTA. disodium ricinoleamido mea-sulfosuccinate. and pant iliner products to reduce bacteria and odor. mineral. The present invention provides for novel formulations of tampon. o. lauramide dea. xanthan gum. hydroxypropylcellulose. 40 Facial cleansing. Clearly Natural. benZophenone-4. and products produced by high-end and names Aapri. iron oxides. isopropyl myristate. Oxy. maxipad and pantiliner products by incorporating bioactive glass into a combination of any of the above-listed ingredients. Johnson & Johnson. cleansing. gelatin. beesWax. Garden Botanika. Water. magnesium aluminum silicate. stearic acid. DMDM hydantoin. bentonite. disodium EDTA. Suave. Pamoxyl. ceteareth-20. silicate. Sastid. sulfur and alcohol or benZoyl perox ide. Fostex. toning. products may also include a fragrance. Freeman. Stiefel. Aquanil Lotion. PEG-75 lanolin oil. Jason. EDTA. Reviva. Bonnie Bell. laureth-4. disodium laureth sulfosuccinate. Zinc oxide. Camocare. La Bella. mineral oil. Zirh. fragrance. hydroxypropyl guar hydroxypropyltri monium chloride. sodium hydroxide. acrylates/Cl0-30 alkyl. salicylic acid. Phisoderm. Alpha Hydrox. Nivea. Curad. or exfoliating products or makeup removal products comprise camphor. Water. Clairol. Garden Botanika. NoxZema. Sal Ac. glyceryl polymethacrylate. Basis. Tampon products may also include one or more of the following: polyethylene/polyester cover. maxipad and pantiliner products comprise cel lulose. glycerin. Clear Logix. T-Zone. toning. RoC. sodium laureth sulfate. various plant and mineral extracts. edetate oxide. Exact. ceramide 3. Rex Eme. triclosan. potas sium hydroxide. anti-aging. A-Derma. PEG-3 distearate. titanium U-Lactin. palmitic acid. Face hydantoin. Palmer’s. Allercreme. ascorbic acid polypep tide (vitamin c). 55 acetylated lanolin alcohol. Facial moisturizing. SFC. Nivea. C. Fruit of the Earth. coco amphocarboxyglycinate. Doak. self-emulsifying Wax. and eye care products and hand and body lotion 40 products comprise Water. Aqua Lactin. Triple Lanolin. talc. salicylic acid. and exfoliating products and makeup removal products to reduce bacteria and in?ammation. Little Forest. Pacquin. Earth Therapeutics. Cetaphil. BHT. Carmol. Vital since it possesses anti-in?ammatory and antimicrobial prop erties. anti Wrinkle. sodium chloride. colloidal oatmeal. Noxzema. Aquanil. Sudden Change. Nutraderm. boric acid. titanium dioxide. Garden Botanika. Zim’s Crack Creme. cetyl ricinoleate. Kerodex 51. butyrolactone. stearic acid. stearyl alcohol. Dixie Health. Earth Science. allanto intetra EDTA. Exorex. Keri. Ca-Rezz. PPG-10 methyl glucose ether. Good Sense. sodium cocoyl isethionate. beesWax. Oilatum Ad. sodium isostearoyl lactylate. cocoa butter. AmLactin. sucrose laurate. Aqua Care. sodium cocoate. Vaseline. Cutar. paraf?n. glycerin. Eye Treatment and Hand and Body Lotion Products The present invention includes novel formulations Which and hand and body lotion products may also include one or more of the folloWing: 1-hexadecanol. Almay. the abra sive quality of bioactive glass is useful in exfoliation. 45 vegetable. cetyl alcohol. Ultra Mide 25. Dermatone. sodium lauroyl sarcosinate. cetyl palmitate. Naturalife. Yardley’s of London. C10-30 cholesterol/ lanosterol esters. castor oil. Xpressions. carbomer. Neutrogena. citric acid. Calgon. quaternium 15. Simply Be Well. linoleamide DEA. Jean Nate. sodium cetyl addition.. PEG-10 soya sterol. Ala Derm. fra acetate and decy glucoside. phosphate. Asorbase. Nature’s Gate. oleyl betaine. PPG-12 buteth-16. cam phor. cetrimo nium chloride. polyquatemium-10. blyceryl stearate. dimethicone. Perfect Solutions. Vas Pet. DiaDermal. Lady Esther. Wibi. Woltra. 65 cetyl octanoate. avobenzone. stearamidopropyl pg-dimonium chloride phosphate. lecithin. sodium palm kemelate. cocobetaine. Nutra-E. iodopropynl. Eucerin. Coral Springs. Hydrox-C. Lift. Formula 405. sodium cocoyl isethionate. phenylethyl alcohol. 20 Care. Beta Care. ammonium glycolate. sesame oil. and eye care products or hand and body lotion products comprise an emollient. St. Rose Milk. Beauty Without Crvetty. Shepard’s. stearamide AMP. Orange Daily. aluminum starch octenyl succinate. sodium cocoyl isethionate. Balm Barr. Additionally. potassium palmitate. steareth-2. and exfoliating products and makeup removal products by incorporating bioactive glass into a combination of any of the above-listed ingredients. PEG-9 Lac-Hydrin Five. J. phenoxyethanol. Natures Family. The Healing stearyl ether. sodium isethionate.174 B2 31 32 acid. Pen-Kera. Stik. Health?oW. Bril lantine. Soft Sense. Basis. Atrac-Tran. eye treatment and hand and body lotion products such as the products mar keted under the brand names Acid Mantle. Alba Botanica. LactiCare. facial moisturizing. ceresin. Bodycology. Lubriderm. toning. Wild Yam Complex. acemannan hydrogel. choleth-24. Seba Nil. 30 Skin formulations comprising bioactive glass also provide dioxide. Fougera. glyceryl stearate. stearic acid. ascorbyl palmitate. Cutemol. Earthly Elements. laureth-3. sodium lauro amphoacetate. sodium borate. ceteth-24. and vitamin extracts and various coloring agents. acrylates/ C10-30 alkyl acrylate crosspolymer. cetearyl octanoate. Baker Cum mins. these formulations Which incorporate bioactive glass may be used to hide shadoWs created by Wrinkles. Golden Sun. polysorbate 20.250. Clairol. simethicone. anti-Wrinkle. glycol stearate. Aveeno. sodium lauryl sulfoacetate. potassium sorbate. In 35 Generally. acrylates copolymer. alpha lipoic acid. fruit. DMDM ing. polyethylene. Lanolar. Abra. cetyl esters. Proteque. Optimum Series. cyclomethicone. Bioactive glass is particularly useful in these products 25 fate. polysorbate 60. Sundance. pentasodium penetate. lauryl methyl gluceth-10 dihydroxypropyldimonium chloride. Sama. The present invention provides for novel formulations of facial cleansing. lauramide MEA. cholesteryl isostearate. Clean & Clear. Curel. copolymer. DPM. State of Mind. Nature’s Apothecary. 60 calcium chloride. In addition. PEG-8. Suave. PEG-10 hydrogenated castor oil. caprylic acid. Common formulations of facial moisturizing. PEG-2 stearate. benzyl alcohol. Stretch Mark. PEG-80 sorbitan laurate. Dermo van. Lander. KC & Company. C12-15 alkyl benzoate.US 7. Lubrex. calcium sulfate. tromethamine. Plenitude. Petal Fresh. MG-217. Chamberlain. and eye care products Facial Moisturizing Anti-Wrinkle. potassium myristate. methylparaben. polyol alkoxy esters. soya sterol. PEG 100 stearate. cetearyl alcohol. Corn Huskers. alcohol. the anti-in?ammatory action of bioactive glass sulfate. chloride. trisodium hedta. Porcelana. Vitec. Theraplex. Oil of Olay. polydecene. Revlon. Nate’ Naturals. polyoxyethylene 15 cocoamine phosphate/oleate comp. Freeman. Ives SWiss Formula. University Medical. PPG-15 RoC. potassium stearate. Der mal Therapy. tetrasodium etibronate. Baby Magic. C13-14isopara?'1n. olive oil. Alpha Keri. sodium PCA. tri ethanolamine. magnesium aluminum silicate. disodium EDTA. ceteareth 20. sodium lauroamphodi a protective HCA layer on the corneal layer of the skin. PG-acetate Lantiseptic. Complex 15. The mild abrasive and high pH in certain formulations generate an exfoliant effect on the skin to remove Wrinkles. pentasodium pentetate. Jockey Club. propylparaben. Brite-Life. PPG-10 butanediol. Prax. Evian. sodium talloWate. ton grance. PEG 20. 50 incorporate bioactive glass into various brands of facial moisturizing. Sea Breeze. PEG-120 glucose dioleate. Jamieson & Co. Carrington. DML. PEG-200 glyceryl talloWate. tetrasodium EDTA. sodium dodecylbenzenesulfonate. Burt’s Bees. polyquaternium-7 capryloyl salicylic acid. PEG-150 distearate. cetyl dimethicone. triclocarban. Jason. CB1. Purpose. Vanicream. sodium cocoyl glutamate. calcium hydroxide. Dermacerin. Gold Bond. sodium sul?te. SWeen. Avon. Galderma. Biore. Albolene. Arthi Care. poloxamer 184. sodium C12-15 alcohol ethoxycarboxylate. sodium lactate. anti-Wrinkle. polyquatemium-24. cholecalciferol. steareth-21. Estar. Nutraderm. polysorbate 80. Pond’s. Sarah Michaels. chlorphenesin. Nutra plu. Naturade. Pretty Feet & Hands. tea-stear ate. butylene glycol. Epilyt. alantoin octyl dimenthyl paba. Esoterica. anti-Wrinkle. The anti-in?ammatory and antimicrobial effects of bio active glass are particularly useful in facial cleansing. Alpha Hydrox. sodium stear ate. Dermasil. sodium trideceth sul Garden. Camocare Gold. octyl hydroxystearate. Aloe Vera 80. DiabetiDerm. Moisturel. Kiss My Face. bisaboloi. petrolatum. La Bella. aloe gel. PEG-120 methyl glucose dioleate. Elta. acrylates/carbamate copolymer. reduces redness and irritation While the anti-microbial action disinfects. apricot kernel oil. sodium lauryl sulfate. propylene glycol. and products produced by high-end and generic manufacturers. Queen Helene. PEG-7 glyceryl cocoate. . ammonium hydroxide. various mineral. lauramide DEA. saf?oWer oil. coco caprylate caprate. benzophenone-4. Shikai. ammonium lactate. a preservative and collagen. Aqua Glycolic. butycarbamate. tridecyl ether. cetyl acetate. sodium myristoyl sarco sinate. Jergens. petrolatum. PVP/hexadecene copolymer.9 0. trilaurin. tetrasodium EDTA.0 Volpo 10 Volpo 3 Jojoba Oil Cyclomethicone D5 tea-carbomer 941. sodium benZoate. SD alcohol 40-b. saccharide isomerate. isostearyl benZoate. propylpa Wt % B Part A polyglycerylmethacrylate.6 10. Wool Wax.0 100. myristyl lactate. sorbic acid.3 Part B 45 Deionized Water NaOH Volpo 10 TiO2 YelloW Iron Oxide Red Iron Oxide 50 50/50 BlacldBroWn Iron Oxide Blend Part C Part D 55 Talc USP vector-delivery system (lipo copolymer complex). phenol. ethoxydiglycol. laureth-4. PEG-5 glyceryl stearate. glyc erin.1 0. makeup formulations incorporating bioactive glass.0 3. The present invention provides for novel formulations of facial moisturizing. pyridox ine HCL (vitamin B6). monoglyceride Wt % 0. polyacrylamide.0 Fragrance (High End Botanicals AFF #ACR2492019E) Citric Acid monohydrate powder Schott Glass sol-gel-derived bioactive glass 0.0 Deionized Water 65. sodium pyruvate. malic acid. PG Formulas CPD3-34 A. trisodium EDTA. PEG 100 stearate. 65 . eucalyptus oil.3 0. isostearic acid. palmitic acid.8 0.0 Jaguar 13S 0.9 0. PEG-8 distearate. sodium stearate. alcohol. progesterone USP.0 100.0 0. sodium hyaluronate. phenylbenZimidaZole sulfonic acid.0 Bioglass 45s @ 1. phenylcarbinol. menthol. steareth-2.1 59. hydrogenated lanolin. includ dioctyl succinate. diisopropyl sebacate.77 p Part E i 60 Germaben II quaterinium-22. INGREDIENTS palmitate. triisocetyl citrate.6 10. stearyl alco hol. collagen. and eye care products and 8.0 1. elastin.0 3. tri citrate. propylene glycol. salicylic acid. polyglyc eryl-3 methyl glucose distearate. octyl methoxycinamate.9 0. oxybenZone. magnesium ascorbyl phosphate. methylchloroisothiaZolinone. distearyldimonium. octyldodecyl neopentanotate. hydrogenated polyisobutane. guar gum. glycolic acid.3 0.0 PolaWax ® 5. sodium DNA. dicaprylyl ether.0 0. emulsi?ers. hydroxyethylcellulose. sodium lauryl sulfate. retinyl Wt % A i 8. anti-Wrinkle. methyl gluceth-20. linseed oil. tridecyl trimellitate. tricaprin. isostearyl alcohol. imidaZolidinyl urea. magnesium sulfate. isodecyl oleate.0 4. silk amino acid. isopropyl palmitate.0 3. dea-cetyl phosphate.8 0. isocetyl stearate. potassium hydroxide. kaolin (natural clay).8 0. nylon-12. meth INGREDIENTS Mineral Oil (70ssu) 20.0 0. stearyl alcohol.0 Observations: Both 34 B and 34 C have more even glass into a combination of any of the above-listed ingredi application than 34 A (the talc formulation) and both feel much less oily than 34 A after drying. 40 Crodafos CES 3.3 0.5 Phenobact 1. dea-oleth-3 phos Examples 9 and 10 beloW provide exemplary embodi phate. isohexadecane. glyceryl dilaurate. menthyl lactate.174 B2 33 34 cyclopentasiloxane. triethanola mine. PEG-100 stearate. meth ylisothiaZolinone. mink oil. sorbitol. glycoproteins. laureth-7. stearamidopropyl PG-dimonium chloride phosphate.6 10. gelatin. hydrolyZed animal protein. PEG-4 dilau rate. sodium calcium alginate. hexyl laurate. diaZolidinyl urea. stearamide dea.8 0. laureth-23. menthyl anthranilate. fumaric acid. stearoxytrimethylsilane. steareth-21.0 Glycerin 2.0 100. dicaprylyl maleate. tea-acrylates/c10-30 alkyl acrylate crosspolymer. PEG-40. trans mine. resorcinol. steapyrium chloride.1 0. polysorbate 20. GMS/PEG 100 stearate. hydrogenated castor oil. polyoxyl 40 stearate. sodium hydroxide and silica. neopentyl glycol dicaprylate/dicaprate.250. PEG-50 stearate. TEA-stearate. sodium carbomer. ethylene brassylate. linolea midopropyl pg-dimonium chloride phosphate. octyl salicylate. mineral oil. sodium chloride. urea.8 0.0 1. quatemium-15. lactic acid. dioctanoate. sodium isos tearoyl lactylate. PVM/MA decadiene crosspolymer.0 100. lanolin.8 0.0 5. ethylhexyl P-methoxycinnamate. myristyl myristate. octyl hydroxystearate. sorbitan laurate. 5 EXAMPLE 9 Composition of Skin Lotion/makeup cose.0 5. sodium cetearyl sulfate. tridecyl stearate. trola i Bioglass 58s @ 0. phe nyldimethicone. glu ing sol-gel-derived bioactive glass. C 35 dioctanoate. PEG-10 soya sterol. octyldodecanol. hand and body lotion products by incorporating bioactive Wt % C 3.1 7.3 0.0 59.1 7. special pet rolatum fraction.0 i i 8. octyl palmitate. PEG-40 stearate. potassium sorbate. distearlydimonium chloride.0 5.3 0. dipropylene glycol. PEG-8 beeswax. phenoxyethanol. lauroyl lysine. sodium borate. polysorbate 40.6 u raben. Base With Sol-gel-derived Bioactive Glass glysine.1 2.0 25 citrate. isopropyl isostear ate. eucalyptol. polysorbate 60. methylisothiaZol. soybean oil.US 7. octyl methoxycinnamate.0 0. isotearyl neopentan date. phospholipids. derrnasterone (bioactive multi Wild yam species com ments of skin lotion/makeup base and cream foundation plex). methylcellu lose. potassium stearate. PEG-15 cocamine. dicaprylate/dicaprate. sodium PCA.1 7. 34 C is less oily than ents. EXAMPLE 10 Cream Foundation Makeup With Bioglass 30 palm oil.0 0.0 1.4 Jaguar C-14S oxypropylgluconamide. oleyl sarcosin. diaZolidinyl urea. B. polyglyceryl-4 isostearate. PVP/ eicosene copolymer.1 Propylene Glycol 3. hyaluronic acid. sorbitan stearate. 34 B. tea. octyldodecyl myristate.1 0.0 0. isopropyl myristate. PEG-8 stearate.1 59. shea butter. squalane. anti-itch products comprise the active ingredi products including products directed to treating athlete’s foot. Generally. as Well as foot pumice products such as the products marketed under the brand ent benZocaine. Family Medic. stearic acid. sulfated castor oil. Aquaphor. olive oil. V1cks. Nupercainal. Medi-Quik. Chiggerex. Tinactin. Anti-itch products may also include one or more of the Fungi Nail. ceteareth-6. WormWood oil. calcium acetate. corn starch. 50 CarraklenZ.250. and various fruit. Polysporin. myristyl myristate. Campho Phenique. Zeasorb. Triple Care. disodium EDTA. ethoxydiglycol. PPG-l trideceth-6. lanolin. method to form a porous solid material for use in a foot pumice. edetate disodium. Dermoplast. monobasic sodium phosphate. Ivarest. Micatin. Mavis. Cruex. sorbitan monostearate. griseofulvin. Beta dine. Polysporin. Tinactin. Rhuli. acrylate copolymer. Orly. SD alcohol 40. Lamisil. aloe vera. dioctyl sodium sulfosuccinate. methyl salicylate. isopropyl alcohol. menthol. cetyl alcohol. glycol.. and products produced by high-end and generic manufacturers. 60 Johnson. After Bite. BFI. Common formulations of antibacterial. Quin folloWing inactive ingredients: l-hexadecanol. diaZolidinyl White petrolatum. chlorothymol. Lanocane. iodopropyl butylcarbamate. Glover’s. benZethonium chloride. aldioxa. Solarcaine. Lanacort. SWeen.174 B2 35 36 Foot Care Products The present invention includes novel formulations Which nol-HC. stearamidoethyl diethy lamine. Trim. Neosporin. dia Zolidinyl urea. Aloe Vesta. Stopain. stearalkonium hectorite. isopropyl myristate. Myciguent. calendula. bisabolol. nitrate. styrene/acrylates copolymer. Vaseline. tocopheryl acetate. sodium acrylates copolymer. cetearyl alcohol. isobutane (propellant). Funginail. novacaine or bacitracin. SD alcohol 40. yelloW Wax. Fougera. Zinc oxide. oatmeal ?our. baci tracin Zinc. microporous cellulose. Ivy-Dry. Fungus Stop. Campho-Phenique. polysorbate 80. carbomer. acid. panthenol. Cortaid. The present invention provides for novel formulations of anti-itch products by incorporating bioactive glass into a potassium iodide. Scholl’s. Unguentine. Arctic Spray. antibiotic and ?rst aid products comprise alcohol. Resinol. Blis-to-Sol. Boil Ease. polyethylene tate. Sar Baciguent. aluminum sulfate. butylene Ting. ceresin. Sensogard. petrolatum. Sportscreme. lidocaine hydrochloride. chloroxylenol. Zephiran Chloride. Sayman. isopropanol. ammonia. poWders may be sintered by any acceptable 25 diphenhydramine HCl. Johnson’s. LA Cross. sodium hydroxide. maltodextrin. camphor. Pretty Feet & Hands. Aveeno. adhe sana. thymol. Exorex. veg urea. coal tar solution. Mycitracin. Clocream. and products produced by high-end and generic incorporate bioactive glass into various brands of foot care manufacturers. glyceryl stearate SE. potato dextrin. CortiZone. Lotrimin. acetic acid. behenoxy dimethicone. Ben Gay. Parex. Gold Bond. triethanolamine. Lanabi otic. bentonite. Spectrocin. MiconaZole. para?in. ceteth-2. TingAF. 30 Common formulations of foot care products comprise active ingredients consisting of a combination of tolnaftate. Mentholatum. Bioactive glass also 20 can be used to create or be incorporated into a foot pumice. Bactine. B-D. menthol. Top Care. glycol. Zinc oxide. Health at Home. pramoxine hydrochloride. mineral oil. Caladryl. Micatin. sodium bicar combination of any of the above-listed ingredients. names Absorbine Jr. quatemium. carbohydrate acrylic copolymer. In addition. starch. Tegrin. Sting Kill. Odor-Eaters. Carrington. Desenex. distearlydimonium chloride. sodium citrate. Gold Bond. glyc erin. miconaZole. Bactine. Humco. sodium borate. Tetterine. Alpha Hydrox. menthol. Caldecort. Ives SWiss Formula. karaya. neomycin and pramoxine hydrochloride. Neutrogena. Bag Balm. Freeman. laneth-l6. Water. Lanacane. Lotrimin. phenol or resorcinol. mineral and vitamin extracts. magnesium stearate and various herbal. 5-chloro-2 methyl-4-isothiaZolin-3-one (and) 2-met. polysorbate 40. cet sives. glyceryl tribehenate. antiseptic. calamine. stearyl alcohol. Medi-Quik. sodium cetearyl sulfate. various coloring agents. antiseptic. Fungiclear. talc. NP-27. Boil Ease. iodine. hydrocortisone. The present invention provides for novel formulations of foot care products by incorporating bioactive glass into a combination of any of the above-listed ingredients. Podiacin. citric acid. Good Sense. Good Sense. Generally. the hygroscopic properties of bioac tive glass help to reduce foot moisture. Nexcare. Benadryl. . Dyna-hex. octoxynol-9. Zinc undecylenate. ben Zalkonium chloride. BaZa. Blue Star. Zinc pyrithione. Der moplast. isopropyl myristate. Brite-Life. plant and mineral extracts. xanthan gum. edetate disodium. stearyl alcohol. Baciguent. benZyl alcohol. Fungi Care. eareth-20. sodium lauryl sulfate. Myci tracin. triglyceryl Antibacterial. Iodex. Americaine. Hibiclens. maltodextrin. Common formulations of anti-itch products comprise active ingredients consisting of a combination of camphor. fragrance. FungiCure. Generally. polysorbate 60. aZole. hydroxypro pyl methylcellulose. Itch-X. Water. cetyl palmitate. SWan. thymol. Blue Star. Lanacort. benZocaine. terbina?ne hydrochloride. Fougera. Earth Therapeutics. bonate. Tecnu. Betadine. dimethicone. Ivy Block. and ?rst aid products comprise active ingredients consisting of a combination of polymyxin B sulfate. Antiseptic. isobu tane. methyl salicylate. methyl gluceth-20. Brite-Life. Foot care products may also include one or more of the 35 folloWing inactive ingredients: acetone. povo-iodine. Lander. antibacterial. Unguentine. Neosporin. steareth-2.US 7. SD alcohol 38-b. Lavocal. steareth-2l. alcohol. Pinaud. Mineral Ice. White Wax. propylene glycol. PEG-2 oleate. KeriCort-lO. titanium dioxide. hydroxypropylcellulose. benZyl alcohol. A?ate. foot care products comprise the active ingre dient allylamine. cetyl palmitate. Foille. fragrance. stearamidoethyl diethy lamine. sodium chloride. fungal conditions and odor. and products produced by high-end and generic manufacturers. Dermarest. BFI. antibi 65 otic. isopropyl palmitate. propylparaben. Lanabiotic. cetyl alcohol. Hibistat. Gold Bond. isos tearyl neopentanoate. Humco. potassium hydroxide. laureth-23. Zinc acetate or Desert Essence. Johnson & 55 Anti-itch Products The present invention includes novel formulations Which incorporate bioactive glass into various brands of anti-itch products such as the products marketed under the brand names A&D Ointment. Flex-All. St. For example. antibiotic and ?rst aid products such as the products marketed under the brand names Absorbine. hydrogen peroxide. stearic acid. kaolin and benZethonium chloride. salicylic incorporate bioactive glass into various brands of antibac terial. The anti-micro bial effect of bioactive glass includes antifugal properties making bioactive glass particularly Well-suited for foot care products. imidurea. 40 etable. Clinipad. isopro pyl alcohol. Antibiotic and First Aid Products 45 The present invention includes novel formulations Which diisostearate. Betasept. Dr. oxiconaZole or tolnaf methylparaben. Out groW. Foot care formulations comprising bioactive glass are anti-microbial and create a soothing effect. antiseptic.