Calbiochem New Products Feb2012

Calbiochem®: Publish or PerishWhat’s New from Calbiochem® Small Molecules, Inhibitors, and Biochemicals EMD Millipore offers the Calbiochem® brand of high quality small molecules that have been cited in thousands of peer-reviewed publications. From libraries and pathway panels to individual small molecules, the Calbiochem® line of products offers the widest range and most cited selection of inhibitors and activators worldwide. Tyrosine Kinase Inhibitors Tyrosine kinases (TKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration, and survival. TKs are prominent targets for anticancer therapeutics. Selective inhibitors of receptor and nonreceptor TKs can thus inhibit tumor development and progression, as well as angiogenesis. EMD Millipore’s inhibitors and new InhibitorSelect™ libraries enable the study of TKs and relevant pathways. Featuring New! InhibitorSelect™ 96-Well Tyrosine Kinase and Phosphatase Inhibitor Library IV (Catalogue No. 539747) This library consists of 83 pharmacologically active, well-documented, cell-permeable, potent and reversible protein kinase and phosphatase inhibitors; the majority of kinase inhibitors are ATP-competitive. They are supplied in a convenient 96-well plate format at a concentration of 10 mM in DMSO. Use this library to advance target identification in drug discovery, biochemical pathway analysis, screening new protein kinases/phosphatases, high content screening and more. The library is supplied with a CD containing comprehensive documentation for each inhibitor. Number of Inhibitors in Library 37 27 6 1 3 1 8 The DART™ Tool The first software application for in-depth visualization of profiling data. Visit www.millipore.com/visualize to try a demo and sign up to start using DART™. Enzyme Family Receptor Tyrosine Kinase (RTK) Tyrosine Kinase (TK) Tyrosine Kinase-like (TKL) PKA, PKG, PKC families (AGC) CDK, MAPK, GSK-3, CLK families (CMGC) Receptor Tyrosine Phosphatase (RTP) Tyrosine Phosphatase (TP) EMD Millipore is a division of Merck KGaA, Darmstadt, Germany 2 012 FEB FEATURED SIGNAlING PATHwAy PANEl New! InhibitorSelect™ FGF Signaling Pathway Inhibitor Panel (Catalogue No. 341612) Fibroblast Growth Factors (FGF) are heparin-binding proteins, which interact with cell surface-associated heparin sulfate proteoglycans to produce a wide array of cellular and physiological effects, such as angiogenesis, wound healing, and embryonic and neural development. Misregulation of FGF signaling has been closely associated with various human diseases, such as Michel aplasia, neoplasia, Parkinson disease, Pheiffer syndrome and hereditary spinocerebellar ataxias. The InhibitorSelect™ FGF Signaling Pathway Inhibitor Panel contains 14 potent, selective, reversible and cell-permeable inhibitors useful for the study of multiple signaling pathways activated by FGF, and provides a means to assess the effects of FGF signaling on diverse biological processes. Highlighted below are inhibitors included in the panel. FGF FGFR • PD-089828 • PD 166866 • PD173074 • Et-18-OCH3 FRS2 • LY 294002 PLCγ GRB2 SOS PIP2 DAG PI 3-K Src PDK-1 Rac1 Akt • Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 • U0126 • PP2 PD-089828 • Rac1 Inhibitor • ZM 336372 Ras PKC • PP2 • Go 6983 Raf1 ERK1/2 MEKs • PD98059 PAK • PD98059 PIX APPI Neuritogenesis PAF F-Actin Cell Survival SEK MEKs MKK3/6 PLA2 • WP1066 • JNK Inhibitor VIII Actin Crosslinking Cell Migration JNK p38 ATF2 Neurite Outgrowth Elk1 Nucleus Src STAT3 Invasion, Migration Proliferation Phosphorylation Calbiochem® Inhibitors 2 2 012 FEB NEw PRODUCTS Signaling Description Dynamin Inhibitor IV, Hydroxy-Dynasore InhibitorSelect™ 96-Well Tyrosine Kinase and Phosphatase Inhibitor Library IV InSolution™ Akt Inhibitor V, Triciribine InSolution™ ERK Inhibitor II, FR180204 InSolution™ PP1 Analog InSolution™ PTP1B Inhibitor  InSolution™ STAT3 Inhibitor III, WP1066 InSolution™ U0126 InSolution™ Y-27632 in DMSO JNK Inhibitor XIII, SR-3306 Phosphatase Inhibitor Cocktail Set II, Lyophilized Phosphatase Inhibitor Cocktail Set IV, Lyophilized PIP3 Antagonist, PITenin-7 REV-ERBa Agonist, GSK4112 Catalogue No. 324413 539747 124038 328010 529605 539749 573129 662009 688002 420147 524636 524633 524618 554716 Metabolism Description Insulin Expression Inducer, BRD7389 Catalogue No. 203709 Cell Division Description MKLP-2 Inhibitor, Paprotrain Catalogue No. 512533 Neurodegeneration Description 14-3-3 Antagonist II, BV02 β-Amyloid Oligomer Inhibitor, K01-162  Catalogue No. 100082 200487 Apoptosis Description Neurogenesis Enhancer, P7C3A20 SHIP1 Inhibitor, 3AC Catalogue No. 480744 565835 Stem Cell Biology Description Wnt Antagonist V Catalogue No. 681677 Cancer Description NOX1 Inhibitor, ML171 EF24 InSolution Src Inhibitor, PP1 Catalogue No. 492002 324510 539571 3 To Place an Order or Receive Technical Assistance In the U.S. and Canada, call toll-free 1-800-645-5476 For other countries across Europe and the world, please visit: www.millipore.com/offices For Technical Service, please visit: www.millipore.com/techservice Get Connected! Join EMD Millipore Bioscience on your favorite social media outlet for the latest updates, news, products, innovations, and contests! facebook.com/EMDMilliporeBioscience twitter.com/EMDMilliporeBio www.emdmillipore.com/offices EMD Millipore, the M logo, InhibitorSelect, and InSolution are trademarks of Merck KGaA, Darmstadt, Germany. Lit No. PR4661EN00 LS-SBU-12-05888 2/2012 Printed in the USA. © 2012 EMD Millipore Corporation, Billerica, MA USA. All rights reserved.